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MICHELLE BARTON

TitleProfessor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. L'Huillier AG, Dipchand AI, Ng VL, Hebert D, Avitzur Y, Solomon M, Ngan BY, Yeung S, Stephens D, Punnett AS, Barton M, Allen UD. Posttransplant Lymphoproliferative Disorder in Pediatric Patients: Characteristics of Disease in EBV-seropositive Recipients. Transplantation. 2019 Aug 01. PMID: 31385930.
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    2. Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy. Cancers (Basel). 2019 May 24; 11(5). PMID: 31137625.
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    3. Gallardo M, Malaney P, Aitken MJL, Zhang X, Link TM, Shah V, Alybayev S, Wu MH, Pageon LR, Ma H, Jacamo R, Yu L, Xu-Monette ZY, Steinman H, Lee HJ, Sarbassov D, Rapado I, Barton MC, Martinez-Lopez J, Bueso-Ramos C, Young KH, Post SM. Uncovering the role of hnRNP K, an RNA-binding protein, in B-cell lymphomas. J Natl Cancer Inst. 2019 May 11. PMID: 31077320.
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    4. L'Huillier AG, Dipchand AI, Ng VL, Hebert D, Avitzur Y, Solomon M, Ngan BY, Stephens D, Punnett AS, Barton M, Allen UD. Posttransplant lymphoproliferative disorder in pediatric patients: Survival rates according to primary sites of occurrence and a proposed clinical categorization. Am J Transplant. 2019 Mar 18. PMID: 30884098.
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    5. Tam J, Papenburg J, Fanella S, Asner S, Barton M, Bergeron C, Desai S, Hui C, Foo C, Langley JM, Leifso K, Ma ML, Pernica J, Robinson J, Singh R, Tapiero B, Allen U. Pediatric Investigators Collaborative Network on Infections in Canada Study of Respiratory Syncytial Virus-associated Deaths in Pediatric Patients in Canada, 2003-2013. Clin Infect Dis. 2019 Jan 01; 68(1):113-119. PMID: 29788036.
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    6. Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M. Corrigendum: p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2018 10 01; 32(19-20):1358. PMID: 30275045.
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    7. Jain AK, Barton MC. p53: emerging roles in stem cells, development and beyond. Development. 2018 04 13; 145(8). PMID: 29654218.
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    8. Appikonda S, Thakkar KN, Shah PK, Dent SYR, Andersen JN, Barton MC. Cross-talk between chromatin acetylation and SUMOylation of tripartite motif-containing protein 24 (TRIM24) impacts cell adhesion. J Biol Chem. 2018 05 11; 293(19):7476-7485. PMID: 29523690.
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    9. Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Kraus WL, Li W, Dent SYR. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics. 2018 02 20; 19(1):150. PMID: 29458327.
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    10. Wang H, Zhao S, Barton M, Rosengart T, Cooney AJ. Reciprocity of Action of Increasing Oct4 and Repressing p53 in Transdifferentiation of Mouse Embryonic Fibroblasts into Cardiac Myocytes. Cell Reprogram. 2018 02; 20(1):27-37. PMID: 29412738.
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    11. Wong J, Timberlake K, Boodhan S, Barton M, Fanella S, Read S, Science M. Canadian Pediatric Antimicrobial Stewardship Programs: Current Resources and Implementation Characteristics. Infect Control Hosp Epidemiol. 2018 03; 39(3):350-354. PMID: 29378669.
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    12. Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome Res. 2018 02; 28(2):159-170. PMID: 29273624.
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    13. Wang L, Koutelou E, Hirsch C, McCarthy R, Schibler A, Lin K, Lu Y, Jeter C, Shen J, Barton MC, Dent SYR. GCN5 Regulates FGF Signaling and Activates Selective MYC Target Genes during Early Embryoid Body Differentiation. Stem Cell Reports. 2018 01 09; 10(1):287-299. PMID: 29249668.
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    14. Bosnakovski D, Gearhart MD, Toso EA, Recht OO, Cucak A, Jain AK, Barton MC, Kyba M. p53-independent DUX4 pathology in cell and animal models of facioscapulohumeral muscular dystrophy. Dis Model Mech. 2017 10 01; 10(10):1211-1216. PMID: 28754837.
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    15. McCarthy RL, Mak DH, Burks JK, Barton MC. Rapid monoisotopic cisplatin based barcoding for multiplexed mass cytometry. Sci Rep. 2017 06 19; 7(1):3779. PMID: 28630464.
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    16. Tovy A, Spiro A, McCarthy R, Shipony Z, Aylon Y, Allton K, Ainbinder E, Furth N, Tanay A, Barton M, Oren M. p53 is essential for DNA methylation homeostasis in naïve embryonic stem cells, and its loss promotes clonal heterogeneity. Genes Dev. 2017 05 15; 31(10):959-972. PMID: 28607180.
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    17. McCarthy RL, Duncan AD, Barton MC. Sample Preparation for Mass Cytometry Analysis. J Vis Exp. 2017 04 29; (122). PMID: 28518070.
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    18. Fiziev P, Akdemir KC, Miller JP, Keung EZ, Samant NS, Sharma S, Natale CA, Terranova CJ, Maitituoheti M, Amin SB, Martinez-Ledesma E, Dhamdhere M, Axelrad JB, Shah A, Cheng CS, Mahadeshwar H, Seth S, Barton MC, Protopopov A, Tsai KY, Davies MA, Garcia BA, Amit I, Chin L, Ernst J, Rai K. Systematic Epigenomic Analysis Reveals Chromatin States Associated with Melanoma Progression. Cell Rep. 2017 04 25; 19(4):875-889. PMID: 28445736.
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    19. Barton M, Shen A, O'Brien K, Robinson JL, Davies HD, Simpson K, Asztalos E, Langley J, Le Saux N, Sauve R, Synnes A, Tan B, de Repentigny L, Rubin E, Hui C, Kovacs L, Yau YC, Richardson SE. Early-Onset Invasive Candidiasis in Extremely Low Birth Weight Infants: Perinatal Acquisition Predicts Poor Outcome. Clin Infect Dis. 2017 Apr 01; 64(7):921-927. PMID: 28077516.
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    20. Yea C, Bitnun A, Robinson J, Mineyko A, Barton M, Mah JK, Vajsar J, Richardson S, Licht C, Brophy J, Crone M, Desai S, Hukin J, Jones K, Muir K, Pernica JM, Pless R, Pohl D, Rafay MF, Selby K, Venkateswaran S, Bernard G, Yeh EA. Longitudinal Outcomes in the 2014 Acute Flaccid Paralysis Cluster in Canada. J Child Neurol. 2017 03; 32(3):301-307. PMID: 28193112.
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    21. Jain AK, Xi Y, McCarthy R, Allton K, Akdemir KC, Patel LR, Aronow B, Lin C, Li W, Yang L, Barton MC. LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Mol Cell. 2016 12 01; 64(5):967-981. PMID: 27912097.
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    22. Jain AK, Barton MC. Bromodomain Histone Readers and Cancer. J Mol Biol. 2017 06 30; 429(13):2003-2010. PMID: 27890782.
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    23. Fratto MA, Hart KA, Norton NA, Barton MH, Giguère S, Hurley DJ. The effect of free and carrier-bound cortisol on equine neutrophil function. Vet Immunol Immunopathol. 2017 Jan; 183:16-21. PMID: 28063472.
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    24. Ma L, Yuan L, An J, Barton MC, Zhang Q, Liu Z. Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer. Tumour Biol. 2016 Nov; 37(11):14803-14812. PMID: 27638829.
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    25. Barton MC. Cancer: Acidic shield puts a chink in p53's armour. Nature. 2016 10 06; 538(7623):45-46. PMID: 27626387.
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    26. Appikonda S, Thakkar KN, Barton MC. Regulation of gene expression in human cancers by TRIM24. Drug Discov Today Technol. 2016 Mar; 19:57-63. PMID: 27769359.
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    27. Jain AK, Barton MC. Outside the p53 RING: Transcription Regulation by Chromatin-Bound MDM2. Mol Cell. 2016 06 16; 62(6):805-807. PMID: 27315554.
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    28. Patel LR, Barton MC. TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer. Cancer Cell. 2016 06 13; 29(6):776-778. PMID: 27300431.
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    29. Jung KH, McCarthy RL, Zhou C, Uprety N, Barton MC, Beretta L. MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1. Stem Cells. 2016 05; 34(5):1284-96. PMID: 26731713.
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    30. Dhar SS, Lee SH, Chen K, Zhu G, Oh W, Allton K, Gafni O, Kim YZ, Tomoiga AS, Barton MC, Hanna JH, Wang Z, Li W, Lee MG. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Res. 2016 05 05; 44(8):3659-74. PMID: 26762983.
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    31. Barton MH, Darden JE, Clifton S, Vandenplas M. Effect of firocoxib on cyclooxygenase 2, microsomal prostaglandin E2 synthase 1, and cytosolic phospholipase A2 gene expression in equine mononuclear cells. Am J Vet Res. 2015 Dec; 76(12):1051-7. PMID: 26618729.
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    32. Rai K, Akdemir KC, Kwong LN, Fiziev P, Wu CJ, Keung EZ, Sharma S, Samant NS, Williams M, Axelrad JB, Shah A, Yang D, Grimm EA, Barton MC, Milton DR, Heffernan TP, Horner JW, Ekmekcioglu S, Lazar AJ, Ernst J, Chin L. Dual Roles of RNF2 in Melanoma Progression. Cancer Discov. 2015 Dec; 5(12):1314-27. PMID: 26450788.
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    33. Thakkar KN, Stratton SA, Craig Barton M. Tissue-specific metabolism and TRIM24. Aging (Albany NY). 2015 Oct; 7(10):736-7. PMID: 26454661.
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    34. Zhan Y, Kost-Alimova M, Shi X, Leo E, Bardenhagen JP, Shepard HE, Appikonda S, Vangamudi B, Zhao S, Tieu TN, Jiang S, Heffernan TP, Marszalek JR, Toniatti C, Draetta G, Tyler J, Barton M, Jones P, Palmer WS, Geck Do MK, Andersen JN. Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics Chromatin. 2015; 8:37. PMID: 26396593.
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    35. McConachie EL, Giguère S, Rapoport G, Barton MH. Heart rate variability in horses with acute gastrointestinal disease requiring exploratory laparotomy. J Vet Emerg Crit Care (San Antonio). 2016 Mar-Apr; 26(2):269-80. PMID: 26260488.
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    36. Palmer WS, Poncet-Montange G, Liu G, Petrocchi A, Reyna N, Subramanian G, Theroff J, Yau A, Kost-Alimova M, Bardenhagen JP, Leo E, Shepard HE, Tieu TN, Shi X, Zhan Y, Zhao S, Barton MC, Draetta G, Toniatti C, Jones P, Geck Do M, Andersen JN. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. J Med Chem. 2016 Feb 25; 59(4):1440-54. PMID: 26061247.
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    37. Hirsch CL, Akdemir ZC, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY. Corrigendum: Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev. 2015 Jun 15; 29(12):1341. PMID: 26109054.
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    38. Lindsey C, Aschenbroich SA, Credille BC, Barton MH, Howerth EW. Pathology in Practice. Ependymoma of the right lateral ventricle with internal hydrocephalus in a horse. J Am Vet Med Assoc. 2015 May 15; 246(10):1067-9. PMID: 25932931.
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    39. Hirsch CL, Coban Akdemir Z, Wang L, Jayakumaran G, Trcka D, Weiss A, Hernandez JJ, Pan Q, Han H, Xu X, Xia Z, Salinger AP, Wilson M, Vizeacoumar F, Datti A, Li W, Cooney AJ, Barton MC, Blencowe BJ, Wrana JL, Dent SY. Myc and SAGA rewire an alternative splicing network during early somatic cell reprogramming. Genes Dev. 2015 Apr 15; 29(8):803-16. PMID: 25877919.
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    40. Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro Oncol. 2015 Nov; 17(11):1463-73. PMID: 25795306.
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    41. Jin C, Qin T, Barton MC, Jelinek J, Issa JP. Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Epigenetics. 2015; 10(11):1006-13. PMID: 26440216.
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    42. Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC. TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. J Hepatol. 2015 Feb; 62(2):371-9. PMID: 25281858.
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    43. Pathiraja TN, Thakkar KN, Jiang S, Stratton S, Liu Z, Gagea M, Shi X, Shah PK, Phan L, Lee MH, Andersen J, Stampfer M, Barton MC. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene. 2015 May 28; 34(22):2836-45. PMID: 25065590.
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    44. Jain AK, Allton K, Duncan AD, Barton MC. TRIM24 is a p53-induced E3-ubiquitin ligase that undergoes ATM-mediated phosphorylation and autodegradation during DNA damage. Mol Cell Biol. 2014 Jul; 34(14):2695-709. PMID: 24820418.
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    45. Jin C, Lu Y, Jelinek J, Liang S, Estecio MR, Barton MC, Issa JP. TET1 is a maintenance DNA demethylase that prevents methylation spreading in differentiated cells. Nucleic Acids Res. 2014 Jun; 42(11):6956-71. PMID: 24875481.
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    46. Wen H, Li Y, Xi Y, Jiang S, Stratton S, Peng D, Tanaka K, Ren Y, Xia Z, Wu J, Li B, Barton MC, Li W, Li H, Shi X. ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression. Nature. 2014 Apr 10; 508(7495):263-8. PMID: 24590075.
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    47. Stratton SA, Barton MC. Hierarchy of a regenerative cell cycle: cyclin E1 multitasks. Hepatology. 2014 Feb; 59(2):370-1. PMID: 23913250.
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    48. Al Fawaz T, Ng V, Richardson SE, Barton M, Allen U. Clinical consequences of human herpesvirus-6 DNAemia in peripheral blood in pediatric liver transplant recipients. Pediatr Transplant. 2014 Feb; 18(1):47-51. PMID: 24384048.
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    49. Zhang X, Tanaka K, Yan J, Li J, Peng D, Jiang Y, Yang Z, Barton MC, Wen H, Shi X. Regulation of estrogen receptor a by histone methyltransferase SMYD2-mediated protein methylation. Proc Natl Acad Sci U S A. 2013 Oct 22; 110(43):17284-9. PMID: 24101509.
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    50. Akdemir KC, Jain AK, Allton K, Aronow B, Xu X, Cooney AJ, Li W, Barton MC. Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Res. 2014 Jan; 42(1):205-23. PMID: 24078252.
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    51. Schmitt ML, Hauser AT, Carlino L, Pippel M, Schulz-Fincke J, Metzger E, Willmann D, Yiu T, Barton M, Schüle R, Sippl W, Jung M. Nonpeptidic propargylamines as inhibitors of lysine specific demethylase 1 (LSD1) with cellular activity. J Med Chem. 2013 Sep 26; 56(18):7334-42. PMID: 24007511.
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    52. Kurinna S, Stratton SA, Coban Z, Schumacher JM, Grompe M, Duncan AW, Barton MC. p53 regulates a mitotic transcription program and determines ploidy in normal mouse liver. Hepatology. 2013 May; 57(5):2004-13. PMID: 23300120.
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    53. Tran MN, Choi W, Wszolek MF, Navai N, Lee IL, Nitti G, Wen S, Flores ER, Siefker-Radtke A, Czerniak B, Dinney C, Barton M, McConkey DJ. The p63 protein isoform ?Np63a inhibits epithelial-mesenchymal transition in human bladder cancer cells: role of MIR-205. J Biol Chem. 2013 Feb 01; 288(5):3275-88. PMID: 23239884.
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    54. Wan M, Liang J, Xiong Y, Shi F, Zhang Y, Lu W, He Q, Yang D, Chen R, Liu D, Barton M, Songyang Z. The trithorax group protein Ash2l is essential for pluripotency and maintaining open chromatin in embryonic stem cells. J Biol Chem. 2013 Feb 15; 288(7):5039-48. PMID: 23239880.
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    55. Jain AK, Barton MC. Unmet expectations: miR-34 plays no role in p53-mediated tumor suppression in vivo. PLoS Genet. 2012; 8(7):e1002859. PMID: 22870065.
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    56. Coban Z, Barton MC. Integrative genomics: liver regeneration and hepatocellular carcinoma. J Cell Biochem. 2012 Jul; 113(7):2179-84. PMID: 22345090.
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    57. Bochkis IM, Schug J, Ye DZ, Kurinna S, Stratton SA, Barton MC, Kaestner KH. Genome-wide location analysis reveals distinct transcriptional circuitry by paralogous regulators Foxa1 and Foxa2. PLoS Genet. 2012; 8(6):e1002770. PMID: 22737085.
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    58. Butterworth KA, Pellegrini-Masini AM, Barton MH. Diagnosis and management of hypoaldosteronism without hypoadrenocorticism in an alpaca. J Am Vet Med Assoc. 2012 Mar 15; 240(6):748-51. PMID: 22380814.
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    59. Morris SK, Parkin P, Science M, Subbarao P, Yau Y, O'Riordan S, Barton M, Allen UD, Tran D. A retrospective cross-sectional study of risk factors and clinical spectrum of children admitted to hospital with pandemic H1N1 influenza as compared to influenza A. BMJ Open. 2012; 2(2):e000310. PMID: 22411932.
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    60. Jain AK, Allton K, Iacovino M, Mahen E, Milczarek RJ, Zwaka TP, Kyba M, Barton MC. p53 regulates cell cycle and microRNAs to promote differentiation of human embryonic stem cells. PLoS Biol. 2012; 10(2):e1001268. PMID: 22389628.
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    61. Hart KA, Dirikolu L, Ferguson DC, Norton NA, Barton MH. Daily endogenous cortisol production and hydrocortisone pharmacokinetics in adult horses and neonatal foals. Am J Vet Res. 2012 Jan; 73(1):68-75. PMID: 22204290.
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    62. Stratton SA, Barton MC. p53-Mediated regulation of hepatic lipid metabolism: forging links between metabolism, atherogenesis, and cancer. J Hepatol. 2012 Mar; 56(3):518-9. PMID: 22051552.
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    63. Mani SA, Barton MC. HDAC3 at the fulcrum of an epithelial-mesenchymal balance. Mol Cell. 2011 Sep 02; 43(5):697-8. PMID: 21884971.
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    64. Hart KA, Barton MH, Vandenplas ML, Hurley DJ. Effects of low-dose hydrocortisone therapy on immune function in neonatal horses. Pediatr Res. 2011 Jul; 70(1):72-7. PMID: 21430601.
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    65. Singh MM, Manton CA, Bhat KP, Tsai WW, Aldape K, Barton MC, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol. 2011 Aug; 13(8):894-903. PMID: 21653597.
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    66. Wilson MA, Koutelou E, Hirsch C, Akdemir K, Schibler A, Barton MC, Dent SY. Ubp8 and SAGA regulate Snf1 AMP kinase activity. Mol Cell Biol. 2011 Aug; 31(15):3126-35. PMID: 21628526.
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    67. House AM, Barton MH, Williamson LH. One-stage prothrombin time, activated partial thromboplastin time, thrombin time, fibrin degradation product concentration, and antithrombin activity in healthy adult alpacas. Vet Clin Pathol. 2011 Jun; 40(2):195-7. PMID: 21554362.
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    68. Hart KA, Barton MH. Adrenocortical insufficiency in horses and foals. Vet Clin North Am Equine Pract. 2011 Apr; 27(1):19-34. PMID: 21392651.
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    69. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16; 468(7326):927-32. PMID: 21164480.
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    70. Mao CA, Tsai WW, Cho JH, Pan P, Barton MC, Klein WH. Neuronal transcriptional repressor REST suppresses an Atoh7-independent program for initiating retinal ganglion cell development. Dev Biol. 2011 Jan 01; 349(1):90-9. PMID: 20969844.
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    71. Jain AK, Barton MC. Making sense of ubiquitin ligases that regulate p53. Cancer Biol Ther. 2010 Oct 01; 10(7):665-72. PMID: 20930521.
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    72. Kurinna S, Stratton SA, Tsai WW, Akdemir KC, Gu W, Singh P, Goode T, Darlington GJ, Barton MC. Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice. Hepatology. 2010 Sep; 52(3):1023-32. PMID: 20564353.
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    73. Dejosez M, Levine SS, Frampton GM, Whyte WA, Stratton SA, Barton MC, Gunaratne PH, Young RA, Zwaka TP. Ronin/Hcf-1 binds to a hyperconserved enhancer element and regulates genes involved in the growth of embryonic stem cells. Genes Dev. 2010 Jul 15; 24(14):1479-84. PMID: 20581084.
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    74. Taube JH, Allton K, Duncan SA, Shen L, Barton MC. Foxa1 functions as a pioneer transcription factor at transposable elements to activate Afp during differentiation of embryonic stem cells. J Biol Chem. 2010 May 21; 285(21):16135-44. PMID: 20348100.
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    75. Kurinna S, Barton MC. Cascades of transcription regulation during liver regeneration. Int J Biochem Cell Biol. 2011 Feb; 43(2):189-97. PMID: 20307684.
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    76. Kurinna S, Barton MC. Hierarchies of transcriptional regulation during liver regeneration. Prog Mol Biol Transl Sci. 2010; 97:201-27. PMID: 21074734.
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    77. O'Riordan S, Barton M, Yau Y, Read SE, Allen U, Tran D. Risk factors and outcomes among children admitted to hospital with pandemic H1N1 influenza. CMAJ. 2010 Jan 12; 182(1):39-44. PMID: 19926677.
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    78. Jain AK, Barton MC. Regulation of p53: TRIM24 enters the RING. Cell Cycle. 2009 Nov 15; 8(22):3668-74. PMID: 19844164.
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    79. Gu D, Sater AK, Ji H, Cho K, Clark M, Stratton SA, Barton MC, Lu Q, McCrea PD. Xenopus delta-catenin is essential in early embryogenesis and is functionally linked to cadherins and small GTPases. J Cell Sci. 2009 Nov 15; 122(Pt 22):4049-61. PMID: 19843587.
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    80. Allen U, Barton M, Beyene J, Hu P, Khodai-Booran N, Hébert D, Dipchand A, Ng V, Solomon M, Grant D, Fecteau A, Ngan B, Read S, Zielenska M, Weitzman S. Gene expression using microarrays in transplant recipients at risk of EBV lymphoproliferation after organ transplantation: preliminary proof-of-concept. Pediatr Transplant. 2009 Dec; 13(8):990-8. PMID: 19735433.
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    81. Barton M, Wasfy S, Dipchand AI, Hébert D, Ng V, Solomon M, Fecteau A, Stephen D, Allen U. Seven-valent pneumococcal conjugate vaccine in pediatric solid organ transplant recipients: a prospective study of safety and immunogenicity. Pediatr Infect Dis J. 2009 Aug; 28(8):688-92. PMID: 19633514.
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    82. Minard ME, Jain AK, Barton MC. Analysis of epigenetic alterations to chromatin during development. Genesis. 2009 Aug; 47(8):559-72. PMID: 19603511.
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    83. Allton K, Jain AK, Herz HM, Tsai WW, Jung SY, Qin J, Bergmann A, Johnson RL, Barton MC. Trim24 targets endogenous p53 for degradation. Proc Natl Acad Sci U S A. 2009 Jul 14; 106(28):11612-6. PMID: 19556538.
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    84. Epstein KL, Brainard BM, Lopes MA, Barton MH, Moore JN. Thrombelastography in 26 healthy horses with and without activation by recombinant human tissue factor. J Vet Emerg Crit Care (San Antonio). 2009 Feb; 19(1):96-101. PMID: 19691590.
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    85. Barton M, Wasfy S, Melbourne T, Hébert D, Moore D, Robinson J, Marchese RD, Allen UD. Sustainability of humoral responses to varicella vaccine in pediatric transplant recipients following a pretransplantation immunization strategy. Pediatr Transplant. 2009 Dec; 13(8):1007-13. PMID: 19207222.
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    86. Barton M, Finkelstein Y, Opavsky MA, Ito S, Ho T, Ford-Jones LE, Taylor G, Benson L, Gold R. Eosinophilic myocarditis temporally associated with conjugate meningococcal C and hepatitis B vaccines in children. Pediatr Infect Dis J. 2008 Sep; 27(9):831-5. PMID: 18664932.
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    87. Xie Z, Zhang H, Tsai W, Zhang Y, Du Y, Zhong J, Szpirer C, Zhu M, Cao X, Barton MC, Grusby MJ, Zhang WJ. Zinc finger protein ZBTB20 is a key repressor of alpha-fetoprotein gene transcription in liver. Proc Natl Acad Sci U S A. 2008 Aug 05; 105(31):10859-64. PMID: 18669658.
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    88. Cirillo LA, Barton MC. Many forkheads in the road to regulation. Symposium on forkhead transcription factor networks in development, signalling and disease. EMBO Rep. 2008 Aug; 9(8):721-4. PMID: 18617889.
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    89. Tsai WW, Nguyen TT, Shi Y, Barton MC. p53-targeted LSD1 functions in repression of chromatin structure and transcription in vivo. Mol Cell Biol. 2008 Sep; 28(17):5139-46. PMID: 18573881.
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    90. Qian J, Sarnaik AA, Bonney TM, Keirsey J, Combs KA, Steigerwald K, Acharya S, Behbehani GK, Barton MC, Lowy AM, Groden J. The APC tumor suppressor inhibits DNA replication by directly binding to DNA via its carboxyl terminus. Gastroenterology. 2008 Jul; 135(1):152-62. PMID: 18474248.
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    91. Wilkinson DS, Tsai WW, Schumacher MA, Barton MC. Chromatin-bound p53 anchors activated Smads and the mSin3A corepressor to confer transforming-growth-factor-beta-mediated transcription repression. Mol Cell Biol. 2008 Mar; 28(6):1988-98. PMID: 18212064.
      View in: PubMed
    92. Johnson AB, Denko N, Barton MC. Hypoxia induces a novel signature of chromatin modifications and global repression of transcription. Mutat Res. 2008 Apr 02; 640(1-2):174-9. PMID: 18294659.
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    93. Barton MH, LeRoy BE. Serum bile acids concentrations in healthy and clinically ill neonatal foals. J Vet Intern Med. 2007 May-Jun; 21(3):508-13. PMID: 17552459.
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    94. Hart KA, Ferguson DC, Heusner GL, Barton MH. Synthetic adrenocorticotropic hormone stimulation tests in healthy neonatal foals. J Vet Intern Med. 2007 Mar-Apr; 21(2):314-21. PMID: 17427394.
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    95. Qian J, Steigerwald K, Combs KA, Barton MC, Groden J. Caspase cleavage of the APC tumor suppressor and release of an amino-terminal domain is required for the transcription-independent function of APC in apoptosis. Oncogene. 2007 Jul 19; 26(33):4872-6. PMID: 17297457.
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    96. Johnson AB, Barton MC. Hypoxia-induced and stress-specific changes in chromatin structure and function. Mutat Res. 2007 May 01; 618(1-2):149-62. PMID: 17292925.
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    97. Hawkes M, Barton M, Conly J, Nicolle L, Barry C, Ford-Jones EL. Community-associated MRSA: superbug at our doorstep. CMAJ. 2007 Jan 02; 176(1):54-6. PMID: 17200391.
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    98. Lohmann KL, Vandenplas ML, Barton MH, Bryant CE, Moore JN. The equine TLR4/MD-2 complex mediates recognition of lipopolysaccharide from Rhodobacter sphaeroides as an agonist. J Endotoxin Res. 2007; 13(4):235-42. PMID: 17956942.
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    99. Chen L, Firozi P, Barton M, Templeton NS. Widespread, exceptionally high levels of histone H3 lysine 4 trimethylation largely mediate "privileged" gene expression. Gene Expr. 2007; 13(4-5):271-82. PMID: 17605300.
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    100. Barton MC, Akli S, Keyomarsi K. Deregulation of cyclin E meets dysfunction in p53: closing the escape hatch on breast cancer. J Cell Physiol. 2006 Dec; 209(3):686-94. PMID: 17001684.
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    101. Fleming KA, Barton MH, Latimer KS. Iron deficiency anemia in a neonatal foal. J Vet Intern Med. 2006 Nov-Dec; 20(6):1495-8. PMID: 17186872.
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    102. Barton MH, Hurley D, Norton N, Heusner G, Costa L, Jones S, Byars D, Watanabe K. Serum lactoferrin and immunoglobulin G concentrations in healthy or ill neonatal foals and healthy adult horses. J Vet Intern Med. 2006 Nov-Dec; 20(6):1457-62. PMID: 17186865.
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    103. Barton MC. Influences along the path to maturity: regulation of cellular levels of RNA. Biochim Biophys Acta. 2006 Aug-Sep; 1759(8-9):385-7. PMID: 17007943.
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    104. Barton M, Hawkes M, Moore D, Conly J, Nicolle L, Allen U, Boyd N, Embree J, Van Horne L, Le Saux N, Richardson S, Moore A, Tran D, Waters V, Vearncombe M, Katz K, Weese JS, Embil J, Ofner-Agostini M, Ford-Jones EL. Guidelines for the prevention and management of community-associated methicillin-resistant Staphylococcus aureus: A perspective for Canadian health care practitioners. Can J Infect Dis Med Microbiol. 2006 Sep; 17 Suppl C:4C-24C. PMID: 23365589.
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    105. Lu X, Zhang N, Vasquez K, Barton M, Legerski R. Repair of psoralen interstrand cross-links in Xenopus laevis egg extracts is highly mutagenic. Biochem Biophys Res Commun. 2005 Oct 14; 336(1):69-75. PMID: 16125670.
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    106. Cui R, Nguyen TT, Taube JH, Stratton SA, Feuerman MH, Barton MC. Family members p53 and p73 act together in chromatin modification and direct repression of alpha-fetoprotein transcription. J Biol Chem. 2005 Nov 25; 280(47):39152-60. PMID: 16203738.
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    107. Vandenplas ML, Moore JN, Barton MH, Roussel AJ, Cohen ND. Concentrations of serum amyloid A and lipopolysaccharide-binding protein in horses with colic. Am J Vet Res. 2005 Sep; 66(9):1509-16. PMID: 16261823.
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    108. Park JI, Kim SW, Lyons JP, Ji H, Nguyen TT, Cho K, Barton MC, Deroo T, Vleminckx K, Moon RT, McCrea PD. Kaiso/p120-catenin and TCF/beta-catenin complexes coordinately regulate canonical Wnt gene targets. Dev Cell. 2005 Jun; 8(6):843-54. PMID: 15935774.
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    109. Nguyen TT, Cho K, Stratton SA, Barton MC. Transcription factor interactions and chromatin modifications associated with p53-mediated, developmental repression of the alpha-fetoprotein gene. Mol Cell Biol. 2005 Mar; 25(6):2147-57. PMID: 15743813.
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    110. Wilkinson DS, Ogden SK, Stratton SA, Piechan JL, Nguyen TT, Smulian GA, Barton MC. A direct intersection between p53 and transforming growth factor beta pathways targets chromatin modification and transcription repression of the alpha-fetoprotein gene. Mol Cell Biol. 2005 Feb; 25(3):1200-12. PMID: 15657445.
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    111. Steigerwald K, Behbehani GK, Combs KA, Barton MC, Groden J. The APC tumor suppressor promotes transcription-independent apoptosis in vitro. Mol Cancer Res. 2005 Feb; 3(2):78-89. PMID: 15755874.
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    112. Barton MH, Sharma P, LeRoy BE, Howerth EW. Hypercalcemia and high serum parathyroid hormone-related protein concentration in a horse with multiple myeloma. J Am Vet Med Assoc. 2004 Aug 01; 225(3):409-13, 376. PMID: 15328717.
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    113. Moore JN, Barton MH. Treatment of endotoxemia. Vet Clin North Am Equine Pract. 2003 Dec; 19(3):681-95. PMID: 14740763.
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    114. Barton MH, Williamson L, Jacks S, Norton N. Body weight, hematologic findings, and serum and plasma biochemical findings of horses competing in a 48-, 83-, or 159-km endurance ride under similar terrain and weather conditions. Am J Vet Res. 2003 Jun; 64(6):746-53. PMID: 12828261.
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    115. Barton MH, Williamson L, Jacks S, Norton N. Effects on plasma endotoxin and eicosanoid concentrations and serum cytokine activities in horses competing in a 48-, 83-, or 159-km endurance ride under similar terrain and weather conditions. Am J Vet Res. 2003 Jun; 64(6):754-61. PMID: 12828262.
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    116. Lohmann KL, Vandenplas M, Barton MH, Moore JN. Lipopolysaccharide from Rhodobacter sphaeroides is an agonist in equine cells. J Endotoxin Res. 2003; 9(1):33-7. PMID: 12691616.
      View in: PubMed
    117. Denko N, Wernke-Dollries K, Johnson AB, Hammond E, Chiang CM, Barton MC. Hypoxia actively represses transcription by inducing negative cofactor 2 (Dr1/DrAP1) and blocking preinitiation complex assembly. J Biol Chem. 2003 Feb 21; 278(8):5744-9. PMID: 12477712.
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    118. Vandenplas ML, Carlson RW, Jeyaretnam BS, McNeill B, Barton MH, Norton N, Murray TF, Moore JN. Rhizobium sin-1 lipopolysaccharide (LPS) prevents enteric LPS-induced cytokine production. J Biol Chem. 2002 Nov 01; 277(44):41811-6. PMID: 12193596.
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    119. Bentley AP, Barton MH, Lee MD, Norton NA, Moore JN. Antimicrobial-induced endotoxin and cytokine activity in an in vitro model of septicemia in foals. Am J Vet Res. 2002 May; 63(5):660-8. PMID: 12013465.
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    120. Barton MC, Stivers DN. Microarray analysis of hepatic-regulated gene expression: specific applications and nonspecific problems. Hepatology. 2002 Mar; 35(3):727-9. PMID: 11870392.
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    121. Ogden SK, Lee KC, Wernke-Dollries K, Stratton SA, Aronow B, Barton MC. p53 targets chromatin structure alteration to repress alpha-fetoprotein gene expression. J Biol Chem. 2001 Nov 09; 276(45):42057-62. PMID: 11572852.
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    122. Barton MC, Crowe AJ. Chromatin alteration, transcription and replication: What's the opening line to the story? Oncogene. 2001 May 28; 20(24):3094-9. PMID: 11420725.
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    123. Rockx DA, Mason R, van Hoffen A, Barton MC, Citterio E, Bregman DB, van Zeeland AA, Vrieling H, Mullenders LH. UV-induced inhibition of transcription involves repression of transcription initiation and phosphorylation of RNA polymerase II. Proc Natl Acad Sci U S A. 2000 Sep 12; 97(19):10503-8. PMID: 10973477.
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    124. Ogden SK, Lee KC, Barton MC. Hepatitis B viral transactivator HBx alleviates p53-mediated repression of alpha-fetoprotein gene expression. J Biol Chem. 2000 Sep 08; 275(36):27806-14. PMID: 10842185.
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    125. Crowe AJ, Piechan JL, Sang L, Barton MC. S-Phase progression mediates activation of a silenced gene in synthetic nuclei. Mol Cell Biol. 2000 Jun; 20(11):4169-80. PMID: 10805758.
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    126. Kroll SL, Paulding WR, Schnell PO, Barton MC, Conaway JW, Conaway RC, Czyzyk-Krzeska MF. von Hippel-Lindau protein induces hypoxia-regulated arrest of tyrosine hydroxylase transcript elongation in pheochromocytoma cells. J Biol Chem. 1999 Oct 15; 274(42):30109-14. PMID: 10514498.
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    127. Crowe AJ, Sang L, Li KK, Lee KC, Spear BT, Barton MC. Hepatocyte nuclear factor 3 relieves chromatin-mediated repression of the alpha-fetoprotein gene. J Biol Chem. 1999 Aug 27; 274(35):25113-20. PMID: 10455192.
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    128. Crowe AJ, Barton MC. Functional analysis of chromatin assembled in synthetic nuclei. Methods. 1999 Feb; 17(2):173-87. PMID: 10075895.
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    129. Lee KC, Crowe AJ, Barton MC. p53-mediated repression of alpha-fetoprotein gene expression by specific DNA binding. Mol Cell Biol. 1999 Feb; 19(2):1279-88. PMID: 9891062.
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    130. Crowe AJ, Barton MC. In vitro reconstitution of nuclei for replication and transcription. Methods Enzymol. 1999; 304:63-76. PMID: 10372356.
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    131. Denko N, Langland R, Barton M, Lieberman MA. Uncoupling of S-phase and mitosis by recombinant cytotoxic necrotizing factor 2 (CNF2). Exp Cell Res. 1997 Jul 10; 234(1):132-8. PMID: 9223378.
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    132. Barton MC, Madani N, Emerson BM. Distal enhancer regulation by promoter derepression in topologically constrained DNA in vitro. Proc Natl Acad Sci U S A. 1997 Jul 08; 94(14):7257-62. PMID: 9207078.
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    133. Barton MC, Emerson BM. Regulated gene expression in reconstituted chromatin and synthetic nuclei. Methods Enzymol. 1996; 274:299-312. PMID: 8902814.
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    134. Barton MC, Emerson BM. Regulated expression of the beta-globin gene locus in synthetic nuclei. Genes Dev. 1994 Oct 15; 8(20):2453-65. PMID: 7958909.
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    135. Barton MC, Madani N, Emerson BM. The erythroid protein cGATA-1 functions with a stage-specific factor to activate transcription of chromatin-assembled beta-globin genes. Genes Dev. 1993 Sep; 7(9):1796-809. PMID: 8370527.
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    136. Barton MC, Hoekstra MF, Emerson BM. Site-directed, recombination-mediated mutagenesis of a complex gene locus. Nucleic Acids Res. 1990 Dec 25; 18(24):7349-55. PMID: 2175433.
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    137. Shapiro DJ, Barton MC, McKearin DM, Chang TC, Lew D, Blume J, Nielsen DA, Gould L. Estrogen regulation of gene transcription and mRNA stability. Recent Prog Horm Res. 1989; 45:29-58; discussion 58-64. PMID: 2682843.
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    138. Barton MC, Shapiro DJ. Transient administration of estradiol-17 beta establishes an autoregulatory loop permanently inducing estrogen receptor mRNA. Proc Natl Acad Sci U S A. 1988 Oct; 85(19):7119-23. PMID: 3174624.
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    139. McKearin DM, Barton MC, Keller MJ, Shapiro DJ. Estrogen induces transcription of the Xenopus laevis serum retinol-binding protein gene. J Biol Chem. 1987 Apr 15; 262(11):4939-42. PMID: 3558378.
      View in: PubMed
    140. Hayward MA, Barton MC, Shapiro DJ. Coordinate estrogen induction of vitellogenin and a small serum protein mRNA in Xenopus laevis liver. Mol Cell Endocrinol. 1985 Feb; 39(2):91-8. PMID: 3838520.
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    141. Keller GA, Barton MC, Shapiro DJ, Singer SJ. 3-Hydroxy-3-methylglutaryl-coenzyme A reductase is present in peroxisomes in normal rat liver cells. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):770-4. PMID: 3883347.
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    142. Clark RE, Martin GG, Barton MC, Shapiro DJ. Production and characterization of monoclonal antibodies to rat liver microsomal 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A. 1982 Jun; 79(12):3734-8. PMID: 6954516.
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    143. Regulation of gene expression in human cancers by TRIM24. Drug Discovery Today: Technologies. 19:57-63.
    144. Editorial. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 618:1-2.
    145. Structure-Guided Design of IACS-9571, a Selective High-Affinity Dual TRIM24-BRPF1 Bromodomain Inhibitor. Journal of Medicinal Chemistry. 59:1440-1454.
    146. Erratum. Developmental Cell. 9:305.
    147. Tissue-specific metabolism and TRIM24. Aging. 7:736-737.
    148. TRIM24 links glucose metabolism with transformation of human mammary epithelial cells. Oncogene.
    149. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-Oncology. 17:1463-1473.
    150. An optional laboratory in molecular techniques as an aid in the teaching of medical biochemistry. Biochemical Education. 27:150-152.
    151. Development of novel cellular histone-binding and chromatin-displacement assays for bromodomain drug discovery. Epigenetics and Chromatin. 8.
    152. Cancer. Nature. 538:45-46.
    153. Bromodomain Histone Readers and Cancer. Journal of Molecular Biology.
    154. Outside the p53 RING. Molecular Cell. 62:805-807.
    155. p53. 364-373.
    156. MicroRNA Regulates Hepatocytic Differentiation of Progenitor Cells by Targeting YAP1. Stem Cells. 34:1284-1296.
    157. Genome-wide profiling reveals stimulus-specific functions of p53 during differentiation and DNA damage of human embryonic stem cells. Nucleic Acids Research. 42:205-223.
    158. LncPRESS1 Is a p53-Regulated LncRNA that Safeguards Pluripotency by Disrupting SIRT6-Mediated De-acetylation of Histone H3K56. Molecular Cell. 64:967-981.
    159. Dual roles of RNF2 in melanoma progression. Cancer Discovery. 5:1314-1327.
    160. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Research. 44:3659-3674.
    161. TRIM28 interacts with EZH2 and SWI/SNF to activate genes that promote mammosphere formation. Oncogene.
    162. Minimal role of base excision repair in TET-induced global DNA demethylation in HEK293T cells. Epigenetics. 10:1006-1013.
    163. Histone H3 lysine 23 acetylation is associated with oncogene TRIM24 expression and a poor prognosis in breast cancer. Tumor Biology. 1-10.
    164. TRIM-ing Ligand Dependence in Castration-Resistant Prostate Cancer. Cancer Cell. 29:776-778.
    165. P53. 345-357.
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