InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Res. 2015 May 01; 75(9):1846-58. PMID: 25877877; PMCID: PMC4417433.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    2. Tian Y, Paramasivam M, Ghosal G, Chen D, Shen X, Huang Y, Akhter S, Legerski R, Chen J, Seidman MM, Qin J, Li L. UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold. Cell Rep. 2015 Mar 31; 10(12):1957-66. PMID: 25818288; PMCID: PMC4748712.
      Citations: 44     Fields:    Translation:HumansCells
    3. Wang J, Chen J, Gong Z. TopBP1 stabilizes BLM protein to suppress sister chromatid exchange. Mol Cell. 2015 Mar 19; 57(6):955-956. PMID: 25794614.
      Citations: 3     Fields:    Translation:Humans
    4. Zhang P, Wang L, Rodriguez-Aguayo C, Yuan Y, Debeb BG, Chen D, Sun Y, You MJ, Liu Y, Dean DC, Woodward WA, Liang H, Yang X, Lopez-Berestein G, Sood AK, Hu Y, Ang KK, Chen J, Ma L. miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13. Nat Commun. 2014 Dec 05; 5:5671. PMID: 25476932; PMCID: PMC4377070.
      Citations: 80     Fields:    Translation:HumansCells
    5. Barton O, Naumann SC, Diemer-Biehs R, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Paull TT, Chen J, Jeggo PA, K?nzel J, Lopez BS, L?brich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol. 2014 Sep 29; 206(7):877-94. PMID: 25267294; PMCID: PMC4178966.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    6. Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Mol Cell Proteomics. 2014 Nov; 13(11):2986-3000. PMID: 25096995; PMCID: PMC4223486.
      Citations: 21     Fields:    Translation:HumansCells
    7. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep; 16(9):864-75. PMID: 25086746; PMCID: PMC4150825.
      Citations: 187     Fields:    Translation:HumansAnimalsCells
    8. Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J. Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J Cell Sci. 2014 May 01; 127(Pt 9):2029-39. PMID: 24569877; PMCID: PMC4004977.
      Citations: 12     Fields:    Translation:HumansCells
    9. Li N, Chen J. ADP-ribosylation: activation, recognition, and removal. Mol Cells. 2014 Jan; 37(1):9-16. PMID: 24552704; PMCID: PMC3907000.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    10. Wang F, Cheng J, Liu D, Sun H, Zhao J, Wang J, Chen J, Su Y, Zou Z. P53-participated cellular and molecular responses to irradiation are cell differentiation-determined in murine intestinal epithelium. Arch Biochem Biophys. 2014 Jan 15; 542:21-7. PMID: 24315958.
      Citations: 3     Fields:    Translation:AnimalsCells
    11. Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec; 15(12):1486-1494. PMID: 24270891; PMCID: PMC3951854.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    12. Wang J, Chen J, Gong Z. TopBP1 controls BLM protein level to maintain genome stability. Mol Cell. 2013 Dec 12; 52(5):667-78. PMID: 24239288; PMCID: PMC3880544.
      Citations: 33     Fields:    Translation:HumansCells
    13. Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J. Defining the protein-protein interaction network of the human hippo pathway. Mol Cell Proteomics. 2014 Jan; 13(1):119-31. PMID: 24126142; PMCID: PMC3879608.
      Citations: 71     Fields:    Translation:HumansCells
    14. Fong KW, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. Whole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol. 2013 Oct 14; 203(1):149-64. PMID: 24127217; PMCID: PMC3798253.
      Citations: 50     Fields:    Translation:HumansCells
    15. Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Oct; 23(10):1215-28. PMID: 23999858; PMCID: PMC3790240.
      Citations: 5     Fields:    Translation:HumansCells
    16. Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z. Akt regulates TPP1 homodimerization and telomere protection. Aging Cell. 2013 Dec; 12(6):1091-9. PMID: 23862686; PMCID: PMC4051222.
      Citations: 16     Fields:    Translation:HumansCells
    17. Leung CC, Sun L, Gong Z, Burkat M, Edwards R, Assmus M, Chen J, Glover JN. Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure. 2013 Aug 06; 21(8):1450-9. PMID: 23891287; PMCID: PMC3760280.
      Citations: 17     Fields:    Translation:HumansCells
    18. Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10640-5. PMID: 23754376; PMCID: PMC3696823.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    19. Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H. BRCA1 is a negative modulator of the PRC2 complex. EMBO J. 2013 May 29; 32(11):1584-97. PMID: 23624935; PMCID: PMC3671259.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    20. Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem. 2013 Apr 19; 288(16):11135-43. PMID: 23486525; PMCID: PMC3630874.
      Citations: 150     Fields:    Translation:HumansCells
    21. Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell. 2013 Mar 07; 49(5):997-1009. PMID: 23333308; PMCID: PMC3595374.
      Citations: 43     Fields:    Translation:HumansCells
    22. Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem. 2013 Mar 01; 288(9):6342-50. PMID: 23329831; PMCID: PMC3585069.
      Citations: 44     Fields:    Translation:HumansCells
    23. Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci. 2013 Feb 01; 126(Pt 3):825-37. PMID: 23264731; PMCID: PMC3619811.
      Citations: 5     Fields:    Translation:HumansCells
    24. Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH, Sin HS. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev. 2012 Dec 15; 26(24):2737-48. PMID: 23249736; PMCID: PMC3533078.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    25. Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 2013 Feb 01; 288(5):3174-83. PMID: 23229552; PMCID: PMC3561539.
      Citations: 44     Fields:    Translation:HumansCells
    26. Ghosal G, Chen J. Alteration/deficiency in activation 3 (ADA3): Regulator of DNA repair and genome stability. Cell Cycle. 2012 Dec 15; 11(24):4496. PMID: 23222062; PMCID: PMC3562290.
      Citations:    Fields:    Translation:Animals
    27. Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J. 2013 Jan 09; 32(1):126-39. PMID: 23178594; PMCID: PMC3545304.
      Citations: 51     Fields:    Translation:HumansCells
    28. Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S. PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res. 2013 Jan 01; 73(1):205-14. PMID: 23117887; PMCID: PMC3538077.
      Citations: 26     Fields:    Translation:HumansCells
    29. Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J, Sarkaria JN. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol. 2012 Dec; 110(3):349-57. PMID: 23054561; PMCID: PMC3535329.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    30. Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 01; 26(17):1959-71. PMID: 22948661; PMCID: PMC3435498.
      Citations: 93     Fields:    Translation:HumansCells
    31. Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem. 2012 Oct 05; 287(41):34225-33. PMID: 22902628; PMCID: PMC3464530.
      Citations: 60     Fields:    Translation:HumansCells
    32. Fei J, Chen J. KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). J Biol Chem. 2012 Oct 12; 287(42):35118-35126. PMID: 22902626; PMCID: PMC3471710.
      Citations: 25     Fields:    Translation:HumansCells
    33. Sorokin AV, Chen J. MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells. Oncogene. 2013 Jun 27; 32(26):3130-8. PMID: 22824790.
      Citations: 30     Fields:    Translation:HumansCells
    34. Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell. 2012 Aug 10; 47(3):410-21. PMID: 22705370; PMCID: PMC3601832.
      Citations: 71     Fields:    Translation:HumansCells
    35. Wu J, Liu C, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem. 2012 Jun 29; 287(27):22919-26. PMID: 22539352; PMCID: PMC3391110.
      Citations: 24     Fields:    Translation:AnimalsCells
    36. Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4491-6. PMID: 22396592; PMCID: PMC3311328.
      Citations: 55     Fields:    Translation:HumansCells
    37. Feng L, Chen J. The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol. 2012 Jan 22; 19(2):201-6. PMID: 22266820; PMCID: PMC3888515.
      Citations: 104     Fields:    Translation:HumansCells
    38. Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol. 2011 Nov 20; 18(12):1400-7. PMID: 22101936; PMCID: PMC3657743.
      Citations: 44     Fields:    Translation:AnimalsCells
    39. Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J. RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst). 2012 Feb 01; 11(2):131-8. PMID: 22036607; PMCID: PMC3779126.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    40. Liu T, Wan L, Wu Y, Chen J, Huang J. hSWS1?SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem. 2011 Dec 02; 286(48):41758-41766. PMID: 21965664; PMCID: PMC3308884.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    41. Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS. Critical roles of ring finger protein RNF8 in replication stress responses. J Biol Chem. 2011 Jun 24; 286(25):22355-61. PMID: 21558560; PMCID: PMC3121383.
      Citations: 24     Fields:    Translation:HumansCells
    42. Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J. WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 2011 Jun; 13(6):728-33. PMID: 21532586; PMCID: PMC3926303.
      Citations: 147     Fields:    Translation:HumansCells
    43. Ichijima Y, Ichijima M, Lou Z, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH, Nussenzweig A. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev. 2011 May 01; 25(9):959-71. PMID: 21536735; PMCID: PMC3084029.
      Citations: 94     Fields:    Translation:AnimalsCells
    44. Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep. 2011 Jun; 12(6):574-80. PMID: 21525954; PMCID: PMC3128281.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    45. Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. J Biol Chem. 2011 Jun 17; 286(24):21393-400. PMID: 21515671; PMCID: PMC3122199.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    46. Gong Z, Chen J. E3 ligase RFWD3 participates in replication checkpoint control. J Biol Chem. 2011 Jun 24; 286(25):22308-13. PMID: 21504906; PMCID: PMC3121377.
      Citations: 27     Fields:    Translation:HumansCells
    47. Wang J, Gong Z, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol. 2011 Apr 18; 193(2):267-73. PMID: 21482717; PMCID: PMC3080258.
      Citations: 61     Fields:    Translation:HumansCells
    48. Yuan J, Chen J. The role of the human SWI5-MEI5 complex in homologous recombination repair. J Biol Chem. 2011 Mar 18; 286(11):9888-93. PMID: 21252223; PMCID: PMC3059048.
      Citations: 20     Fields:    Translation:HumansCells
    49. Wang W, Huang J, Chen J. Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem. 2011 Feb 11; 286(6):4364-70. PMID: 21187284; PMCID: PMC3039387.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    50. Ting L, Jun H, Junjie C. RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair (Amst). 2010 Dec 10; 9(12):1241-8. PMID: 20971043.
      Citations: 15     Fields:    Translation:Cells
    51. Leung CC, Gong Z, Chen J, Glover JN. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem. 2011 Feb 11; 286(6):4292-301. PMID: 21127055; PMCID: PMC3039391.
      Citations: 32     Fields:    Translation:HumansCells
    52. Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P, Dray E. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol. 2010 Oct; 17(10):1255-9. PMID: 20871616; PMCID: PMC2950913.
      Citations: 86     Fields:    Translation:HumansCells
    53. Liu T, Ghosal G, Yuan J, Chen J, Huang J. FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science. 2010 Aug 06; 329(5992):693-6. PMID: 20671156.
      Citations: 149     Fields:    Translation:HumansCells
    54. Feng L, Wang J, Chen J. The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem. 2010 Oct 01; 285(40):30982-8. PMID: 20656690; PMCID: PMC2945589.
      Citations: 55     Fields:    Translation:HumansCells
    55. Sy SM, Chen J, Huen MS. The 53BP1-EXPAND1 connection in chromatin structure regulation. Nucleus. 2010 Nov-Dec; 1(6):472-4. PMID: 21327088; PMCID: PMC3027048.
      Citations: 7     Fields:    Translation:HumansCells
    56. Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J. SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle. 2010 Jul 01; 9(13):2679-85. PMID: 20581448; PMCID: PMC3040851.
      Citations: 22     Fields:    Translation:HumansCells
    57. Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell. 2010 Jun 25; 38(6):864-78. PMID: 20620956.
      Citations: 324     Fields:    Translation:HumansAnimalsCells
    58. Huen MS, Chen J. ATM Creates a veil of transcriptional silence. Cell. 2010 Jun 11; 141(6):924-6. PMID: 20550929.
      Citations: 3     Fields:    
    59. Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: to be or not to be. FEBS Lett. 2010 Sep 10; 584(17):3717-24. PMID: 20493860; PMCID: PMC3695482.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    60. Santos MA, Huen MS, Jankovic M, Chen HT, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, L?pez-Contreras AJ, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med. 2010 May 10; 207(5):973-81. PMID: 20385748; PMCID: PMC2867275.
      Citations: 56     Fields:    Translation:AnimalsCells
    61. Park G, Gong Z, Chen J, Kim JE. Characterization of the DOT1L network: implications of diverse roles for DOT1L. Protein J. 2010 Apr; 29(3):213-23. PMID: 20431927.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    62. Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell. 2010 Mar 26; 37(6):854-64. PMID: 20347427; PMCID: PMC3695488.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    63. Gong Z, Kim JE, Leung CC, Glover JN, Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell. 2010 Feb 12; 37(3):438-46. PMID: 20159562; PMCID: PMC3695484.
      Citations: 90     Fields:    Translation:HumansCells
    64. Wang J, Chen J. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem. 2010 Apr 09; 285(15):11458-64. PMID: 20100829; PMCID: PMC2857024.
      Citations: 62     Fields:    Translation:HumansCells
    65. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010 Feb; 120(2):545-58. PMID: 20071779; PMCID: PMC2810074.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    66. Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol. 2010 Feb; 11(2):138-48. PMID: 20029420; PMCID: PMC3899800.
      Citations: 263     Fields:    Translation:HumansAnimalsCells
    67. Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF. CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res. 2010 Mar; 38(5):1489-503. PMID: 20008512; PMCID: PMC2836575.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    68. Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol. 2010 Feb 05; 395(5):908-15. PMID: 19925808; PMCID: PMC2813331.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    69. Yuan J, Chen J. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem. 2010 Jan 08; 285(2):1097-104. PMID: 19910469; PMCID: PMC2801237.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    70. Kim JE, Lou Z, Chen J. Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle. 2009 Nov 15; 8(22):3784-5. PMID: 19855164.
      Citations: 19     Fields:    Translation:HumansCells
    71. Huen MS, Chen J. Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci. 2010 Feb; 35(2):101-8. PMID: 19875294; PMCID: PMC3209802.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    72. Ande SR, Chen J, Maddika S. The ubiquitin pathway: an emerging drug target in cancer therapy. Eur J Pharmacol. 2009 Dec 25; 625(1-3):199-205. PMID: 19835866.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    73. Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev. 2009 Oct 15; 23(20):2394-9. PMID: 19793864; PMCID: PMC2764499.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    74. Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem. 2009 Nov 13; 284(46):31746-52. PMID: 19759395; PMCID: PMC2797245.
      Citations: 44     Fields:    Translation:HumansCells
    75. Kim JE, Chen J, Lou Z. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle. 2009 Sep 15; 8(18):2932-5. PMID: 19657230; PMCID: PMC2777512.
      Citations: 21     Fields:    Translation:Humans
    76. Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell. 2009 Aug 28; 35(4):534-41. PMID: 19716796; PMCID: PMC3392030.
      Citations: 163     Fields:    Translation:AnimalsCells
    77. Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest. 2009 Sep; 119(9):2714-24. PMID: 19690386; PMCID: PMC2735912.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    78. Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 14; 35(3):384-93. PMID: 19683501; PMCID: PMC2756616.
      Citations: 75     Fields:    Translation:HumansCells
    79. Sy SM, Huen MS, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem. 2009 Aug 07; 284(32):21127-31. PMID: 19553677; PMCID: PMC2755835.
      Citations: 45     Fields:    Translation:HumansCells
    80. Sy SM, Huen MS, Zhu Y, Chen J. PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem. 2009 Jul 03; 284(27):18302-10. PMID: 19423707; PMCID: PMC2709360.
      Citations: 53     Fields:    Translation:HumansCells
    81. Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J. RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol. 2009 May; 11(5):592-603. PMID: 19396164; PMCID: PMC2743127.
      Citations: 150     Fields:    Translation:HumansCells
    82. Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7155-60. PMID: 19369211; PMCID: PMC2678481.
      Citations: 267     Fields:    Translation:HumansCells
    83. Maddika S, Sy SM, Chen J. Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem. 2009 May 08; 284(19):12998-3003. PMID: 19321445; PMCID: PMC2676032.
      Citations: 16     Fields:    Translation:HumansCells
    84. Maddika S, Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol. 2009 Apr; 11(4):409-19. PMID: 19287380; PMCID: PMC2754075.
      Citations: 91     Fields:    Translation:HumansCells
    85. Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem. 2009 Mar 13; 284(11):7284-93. PMID: 19124460; PMCID: PMC2652327.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    86. Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol. 2009 Feb; 11(2):204-10. PMID: 19098900; PMCID: PMC2712943.
      Citations: 51     Fields:    Translation:HumansCells
    87. Huen MS, Chen J. When loose ends finally meet. Nat Struct Mol Biol. 2008 Dec; 15(12):1241-2. PMID: 19050718.
      Citations:    Fields:    Translation:Cells
    88. Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol. 2009 Feb; 29(3):849-60. PMID: 19015238; PMCID: PMC2630672.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    89. Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem. 2008 Nov 14; 283(46):31785-90. PMID: 18801727; PMCID: PMC2581543.
      Citations: 47     Fields:    Translation:AnimalsCells
    90. Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol. 2008 Nov; 28(22):6870-6. PMID: 18794363; PMCID: PMC2573299.
      Citations: 64     Fields:    Translation:HumansAnimals
    91. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol. 2008 Sep; 10(9):1076-82. PMID: 19160488; PMCID: PMC2882053.
      Citations: 191     Fields:    Translation:HumansCells
    92. Wood JL, Chen J. DNA-damage checkpoints: location, location, location. Trends Cell Biol. 2008 Oct; 18(10):451-5. PMID: 18760607.
      Citations: 8     Fields:    Translation:AnimalsCells
    93. Wood JL, Liang Y, Li K, Chen J. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem. 2008 Oct 24; 283(43):29586-92. PMID: 18718915; PMCID: PMC2570891.
      Citations: 60     Fields:    Translation:HumansCells
    94. Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol. 2008 Oct; 28(19):6104-12. PMID: 18678647; PMCID: PMC2547017.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    95. Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11200-5. PMID: 18678890; PMCID: PMC2516250.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    96. Wu L, Beito T, Chen J. Generation and characterization of novel monoclonal antibodies against human aurora-A. Hybridoma (Larchmt). 2008 Aug; 27(4):313-8. PMID: 18707550; PMCID: PMC3186696.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    97. Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G. Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol. 2008 Aug 29; 381(2):361-72. PMID: 18582474; PMCID: PMC2574983.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    98. Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol. 2008 Jun 02; 181(5):727-35. PMID: 18504301; PMCID: PMC2396806.
      Citations: 55     Fields:    Translation:AnimalsCells
    99. Kim H, Chen J. New players in the BRCA1-mediated DNA damage responsive pathway. Mol Cells. 2008 Jun 30; 25(4):457-61. PMID: 18443409; PMCID: PMC3873642.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    100. Huang J, Chen J. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. Oncogene. 2008 Jul 03; 27(29):4056-64. PMID: 18332868.
      Citations: 42     Fields:    Translation:HumansCells
    101. Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem. 2008 Apr 25; 283(17):11073-7. PMID: 18319261; PMCID: PMC2431066.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    102. Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol. 2008 Apr; 28(8):2825-39. PMID: 18285465; PMCID: PMC2293113.
      Citations: 245     Fields:    Translation:AnimalsCells
    103. Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature. 2008 Jan 31; 451(7178):583-6. PMID: 18235501.
      Citations: 282     Fields:    Translation:HumansCells
    104. Huen MS, Chen J. The DNA damage response pathways: at the crossroad of protein modifications. Cell Res. 2008 Jan; 18(1):8-16. PMID: 18087291.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    105. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell. 2007 Dec 28; 28(6):1045-57. PMID: 18158901; PMCID: PMC2275782.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    106. Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 2007 Nov 30; 131(5):901-14. PMID: 18001825; PMCID: PMC2149842.
      Citations: 559     Fields:    Translation:HumansCells
    107. Wood JL, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007 Nov 30; 282(48):35416-23. PMID: 17925396; PMCID: PMC2128040.
      Citations: 54     Fields:    Translation:HumansCells
    108. Kim H, Chen J. c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem Biophys Res Commun. 2007 Nov 03; 362(4):842-7. PMID: 17765874; PMCID: PMC2047600.
      Citations: 5     Fields:    Translation:HumansCells
    109. Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol. 2007 Aug; 14(8):710-5. PMID: 17643122.
      Citations: 113     Fields:    Translation:HumansCells
    110. Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science. 2007 May 25; 316(5828):1202-5. PMID: 17525342.
      Citations: 299     Fields:    Translation:HumansCells
    111. Ahmed EA, van der Vaart A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG, Barten A. Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst). 2007 Sep 01; 6(9):1243-54. PMID: 17376750.
      Citations: 35     Fields:    Translation:AnimalsCells
    112. Reina-San-Martin B, Chen J, Nussenzweig MC, Nussenzweig A. Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol. 2007 Jan; 37(1):235-9. PMID: 17183606.
      Citations: 65     Fields:    Translation:AnimalsCells
    113. Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006 Dec 29; 127(7):1361-73. PMID: 17190600; PMCID: PMC1804291.
      Citations: 498     Fields:    Translation:HumansCells
    114. Ward I, Kim JE, Minn K, Chini CC, Mer G, Chen J. The tandem BRCT domain of 53BP1 is not required for its repair function. J Biol Chem. 2006 Dec 15; 281(50):38472-7. PMID: 17043355; PMCID: PMC1853281.
      Citations: 42     Fields:    Translation:HumansCells
    115. Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science. 2006 Oct 13; 314(5797):294-7. PMID: 17038621.
      Citations: 163     Fields:    Translation:HumansAnimalsCells
    116. Lai M, Chen J. The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function. Cell Cycle. 2006 Oct; 5(19):2275-80. PMID: 16969134.
      Citations: 7     Fields:    Translation:HumansCells
    117. Chini CC, Chen J. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem. 2006 Nov 03; 281(44):33276-82. PMID: 16963448.
      Citations: 31     Fields:    Translation:HumansCells
    118. Wu X, Dong X, Liu W, Chen J. Characterization of CHEK2 mutations in prostate cancer. Hum Mutat. 2006 Aug; 27(8):742-7. PMID: 16835864.
      Citations: 14     Fields:    Translation:HumansCells
    119. Yu X, Fu S, Lai M, Baer R, Chen J. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes Dev. 2006 Jul 01; 20(13):1721-6. PMID: 16818604; PMCID: PMC1522068.
      Citations: 142     Fields:    Translation:HumansCells
    120. Lou Z, Chen J. Cellular senescence and DNA repair. Exp Cell Res. 2006 Aug 15; 312(14):2641-6. PMID: 16893723.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    121. Kim JE, Minter-Dykhouse K, Chen J. Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses. Mol Carcinog. 2006 Jun; 45(6):403-8. PMID: 16691596.
      Citations: 17     Fields:    Translation:HumansCells
    122. Chini CC, Wood J, Chen J. Chk1 is required to maintain claspin stability. Oncogene. 2006 Jul 13; 25(30):4165-71. PMID: 16501606.
      Citations: 26     Fields:    Translation:HumansCells
    123. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20; 21(2):201-14. PMID: 16427010.
      Citations: 154     Fields:    Translation:AnimalsCells
    124. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Paull TT, Alt FW, Chen J, Nussenzweig A. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan 20; 21(2):187-200. PMID: 16427009.
      Citations: 318     Fields:    Translation:AnimalsCells
    125. Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 2006 Mar 02; 440(7080):105-9. PMID: 16400328; PMCID: PMC4601098.
      Citations: 170     Fields:    Translation:AnimalsCells
    126. Lai M, Zimmerman ES, Planelles V, Chen J. Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol. 2005 Dec; 79(24):15443-51. PMID: 16306615; PMCID: PMC1315993.
      Citations: 57     Fields:    Translation:HumansCells
    127. Kim JE, McAvoy SA, Smith DI, Chen J. Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol. 2005 Dec; 25(24):10907-15. PMID: 16314514; PMCID: PMC1316943.
      Citations: 33     Fields:    Translation:HumansCells
    128. Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol. 2005 Nov; 25(22):10079-86. PMID: 16260621; PMCID: PMC1280262.
      Citations: 46     Fields:    Translation:AnimalsCells
    129. Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol. 2005 Dec; 17(6):583-9. PMID: 16226453.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    130. Karnitz LM, Flatten KS, Wagner JM, Loegering D, Hackbarth JS, Arlander SJ, Vroman BT, Thomas MB, Baek YU, Hopkins KM, Lieberman HB, Chen J, Cliby WA, Kaufmann SH. Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Mol Pharmacol. 2005 Dec; 68(6):1636-44. PMID: 16126823.
      Citations: 68     Fields:    Translation:HumansCells
    131. Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z, Cadi?anos J, L?pez-Ot?n C. Genomic instability in laminopathy-based premature aging. Nat Med. 2005 Jul; 11(7):780-5. PMID: 15980864.
      Citations: 264     Fields:    Translation:HumansAnimalsCells
    132. Lou Z, Minter-Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol. 2005 Jul; 12(7):589-93. PMID: 15965487.
      Citations: 58     Fields:    Translation:Cells
    133. Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell Death Differ. 2005 Apr; 12(4):326-34. PMID: 15650754.
      Citations: 38     Fields:    Translation:HumansCells
    134. Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J. Chfr is required for tumor suppression and Aurora A regulation. Nat Genet. 2005 Apr; 37(4):401-6. PMID: 15793587.
      Citations: 90     Fields:    Translation:AnimalsCells
    135. Ohashi A, Zdzienicka MZ, Chen J, Couch FJ. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem. 2005 Apr 15; 280(15):14877-83. PMID: 15671039.
      Citations: 33     Fields:    Translation:HumansCells
    136. Lou Z, Chen J. Mammalian DNA damage response pathway. Adv Exp Med Biol. 2005; 570:425-55. PMID: 18727510.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    137. Kim JE, Billadeau DD, Chen J. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem. 2005 Feb 18; 280(7):5733-9. PMID: 15545273.
      Citations: 59     Fields:    Translation:HumansCells
    138. Yu X, Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol. 2004 Nov; 24(21):9478-86. PMID: 15485915; PMCID: PMC522253.
      Citations: 219     Fields:    Translation:HumansAnimalsCells
    139. Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V. Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol. 2004 Nov; 24(21):9286-94. PMID: 15485898; PMCID: PMC522272.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    140. Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J, Khanna K, Delia D. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene. 2004 Oct 07; 23(46):7691-700. PMID: 15361830.
      Citations: 39     Fields:    Translation:HumansCells
    141. Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem. 2004 Nov 05; 279(45):46359-62. PMID: 15377652.
      Citations: 35     Fields:    Translation:HumansCells
    142. Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Chen J, Halazonetis TD, Harris CC, Nussenzweig A. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol. 2004 Sep 13; 166(6):801-13. PMID: 15364958; PMCID: PMC2172115.
      Citations: 65     Fields:    Translation:HumansCells
    143. Chini CC, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. DNA Repair (Amst). 2004 Aug-Sep; 3(8-9):1033-7. PMID: 15279790.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    144. Botuyan MV, Yu X, Juranic N, Macura S, Chen J, Mer G, Nomin? Y. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure. 2004 Jul; 12(7):1137-46. PMID: 15242590; PMCID: PMC3652423.
      Citations: 50     Fields:    Translation:HumansCells
    145. Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. J Cell Biol. 2004 May 24; 165(4):459-64. PMID: 15159415; PMCID: PMC2172356.
      Citations: 170     Fields:    Translation:AnimalsCells
    146. Ward IM, Minn K, Chen J. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. J Biol Chem. 2004 Mar 12; 279(11):9677-80. PMID: 14742437.
      Citations: 99     Fields:    Translation:HumansCells
    147. Ward I, Chen J. Early events in the DNA damage response. Curr Top Dev Biol. 2004; 63:1-35. PMID: 15536012.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    148. Lou Z, Chen J. Use of siRNA to study the function of MDC1 in DNA damage responses. Methods Mol Biol. 2004; 281:179-87. PMID: 15220529.
      Citations: 3     Fields:    Translation:HumansCells
    149. Rodriguez M, Yu X, Chen J, Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. J Biol Chem. 2003 Dec 26; 278(52):52914-8. PMID: 14578343.
      Citations: 104     Fields:    Translation:HumansCells
    150. Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science. 2003 Oct 24; 302(5645):639-42. PMID: 14576433.
      Citations: 405     Fields:    Translation:HumansCells
    151. Wu X, Chen J. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. J Biol Chem. 2003 Sep 19; 278(38):36163-8. PMID: 12855706.
      Citations: 19     Fields:    Translation:HumansCells
    152. Yamane K, Chen J, Kinsella TJ. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res. 2003 Jun 15; 63(12):3049-53. PMID: 12810625.
      Citations: 23     Fields:    Translation:HumansCells
    153. Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem. 2003 Aug 08; 278(32):30057-62. PMID: 12766152.
      Citations: 109     Fields:    Translation:HumansCells
    154. Merkle CJ, Karnitz LM, Chen J, Henry-S?nchez JT. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. J Biol Chem. 2003 Aug 08; 278(32):30051-6. PMID: 12766176.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    155. Ward IM, Minn K, Jorda KG, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. J Biol Chem. 2003 May 30; 278(22):19579-82. PMID: 12697768.
      Citations: 136     Fields:    Translation:Cells
    156. Ward IM, Minn K, van Deursen J, Chen J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Mol Cell Biol. 2003 Apr; 23(7):2556-63. PMID: 12640136; PMCID: PMC150747.
      Citations: 212     Fields:    Translation:AnimalsCells
    157. Lou Z, Chini CC, Minter-Dykhouse K, Chen J. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. J Biol Chem. 2003 Apr 18; 278(16):13599-602. PMID: 12611903.
      Citations: 51     Fields:    Translation:HumansCells
    158. Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature. 2003 Feb 27; 421(6926):957-61. PMID: 12607004.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    159. Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol. 2002 Dec; 4(12):993-7. PMID: 12447390.
      Citations: 269     Fields:    Translation:AnimalsCells
    160. Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem. 2002 Mar 08; 277(10):7849-56. PMID: 11751867.
      Citations: 62     Fields:    Translation:HumansCells
    161. Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. J Biol Chem. 2001 Dec 21; 276(51):47759-62. PMID: 11673449.
      Citations: 517     Fields:    Translation:HumansCells
    162. Ward IM, Wu X, Chen J. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. J Biol Chem. 2001 Dec 21; 276(51):47755-8. PMID: 11668173.
      Citations: 34     Fields:    Translation:Cells
    163. Joukov V, Chen J, Fox EA, Green JB, Livingston DM. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A. 2001 Oct 09; 98(21):12078-83. PMID: 11593018; PMCID: PMC59770.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    164. Rappold I, Iwabuchi K, Date T, Chen J. Tumor suppressor p53 binding protein 1 (53BP1) is involved in DNA damage-signaling pathways. J Cell Biol. 2001 Apr 30; 153(3):613-20. PMID: 11331310; PMCID: PMC2190566.
      Citations: 204     Fields:    Translation:HumansCells
    165. Wu X, Webster SR, Chen J. Characterization of tumor-associated Chk2 mutations. J Biol Chem. 2001 Jan 26; 276(4):2971-4. PMID: 11053450.
      Citations: 45     Fields:    Translation:Humans
    166. Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM. Genetic analysis of BRCA1 function in a defined tumor cell line. Mol Cell. 1999 Dec; 4(6):1093-9. PMID: 10635334.
      Citations: 134     Fields:    Translation:HumansCells
    167. Chen JJ, Silver D, Cantor S, Livingston DM, Scully R. BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway. Cancer Res. 1999 Apr 01; 59(7 Suppl):1752s-1756s. PMID: 10197592.
      Citations: 80     Fields:    Translation:HumansCells
    168. Wilson CA, Ramos L, Anders KH, Press MF, Clarke K, Karlan B, Chen JJ, Scully R, Livingston D, Zuch RH, Kanter MH, Cohen S, Calzone FJ, Slamon DJ, Villase?or MR. Localization of human BRCA1 and its loss in high-grade, non-inherited breast carcinomas. Nat Genet. 1999 Feb; 21(2):236-40. PMID: 9988281.
      Citations: 130     Fields:    Translation:HumansCells
    169. Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Mol Cell. 1998 Sep; 2(3):317-28. PMID: 9774970.
      Citations: 188     Fields:    Translation:HumansCells
    170. Geraghty DS, Sucic HB, Chen J, Pederson DS. Evidence that partial unwrapping of DNA from nucleosomes facilitates the binding of heat shock factor following DNA replication in yeast. J Biol Chem. 1998 Aug 07; 273(32):20463-72. PMID: 9685401.
      Citations: 7     Fields:    Translation:AnimalsCells
    171. Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol. 1998 May; 18(5):2758-67. PMID: 9566895; PMCID: PMC110655.
      Citations: 89     Fields:    Translation:HumansCells
    172. Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 1997 Aug 08; 90(3):425-35. PMID: 9267023.
      Citations: 281     Fields:    Translation:HumansCells
    173. Noel F, Ijichi A, Chen JJ, Gumin GJ, Tofilon PJ. X-ray-mediated reduction in basic fibroblast growth factor expression in primary rat astrocyte cultures. Radiat Res. 1997 Apr; 147(4):484-9. PMID: 9092929.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    174. Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 1997 Jan 24; 88(2):265-75. PMID: 9008167.
      Citations: 429     Fields:    Translation:HumansCells
    175. Chen U, Chen S, Saha P, Dutta A. p21Cip1/Waf1 disrupts the recruitment of human Fen1 by proliferating-cell nuclear antigen into the DNA replication complex. Proc Natl Acad Sci U S A. 1996 Oct 15; 93(21):11597-602. PMID: 8876181; PMCID: PMC38103.
      Citations: 38     Fields:    Translation:HumansCells
    176. Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Mol Cell Biol. 1996 Sep; 16(9):4673-82. PMID: 8756624; PMCID: PMC231467.
      Citations: 110     Fields:    Translation:AnimalsCells
    177. Leiter LM, Chen J, Marathe T, Tanaka M, Dutta A. Loss of transactivation and transrepression function, and not RPA binding, alters growth suppression by p53. Oncogene. 1996 Jun 20; 12(12):2661-8. PMID: 8700525.
      Citations: 11     Fields:    Translation:HumansCells
    178. Chen J, Peters R, Saha P, Lee P, Theodoras A, Pagano M, Wagner G, Dutta A. A 39 amino acid fragment of the cell cycle regulator p21 is sufficient to bind PCNA and partially inhibit DNA replication in vivo. Nucleic Acids Res. 1996 May 01; 24(9):1727-33. PMID: 8649992; PMCID: PMC145832.
      Citations: 17     Fields:    Translation:HumansCells
    179. Chen J, Ding M, Pederson DS. Binding of TFIID to the CYC1 TATA boxes in yeast occurs independently of upstream activating sequences. Proc Natl Acad Sci U S A. 1994 Dec 06; 91(25):11909-13. PMID: 7991556; PMCID: PMC45345.
      Citations: 25     Fields:    Translation:AnimalsCells
    180. Chen J, Pederson DS. A distal heat shock element promotes the rapid response to heat shock of the HSP26 gene in the yeast Saccharomyces cerevisiae. J Biol Chem. 1993 Apr 05; 268(10):7442-8. PMID: 8463277.
      Citations: 14     Fields:    Translation:AnimalsCells
    181. Drug target prediction for colorectal cancer by combining ontology and network approaches. 67.
    182. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Current Biology. 26:3257-3268.
    183. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology.
    184. BRCA proteins and DNA damage checkpoints. Frontiers in Bioscience. 8.
    185. Monoclonal antibody to human Aurora-A. Hybridoma. 27:326.
    186. Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability. Hepatology. 65:678-693.
    187. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology.
    188. Modularized Functions of the Fanconi Anemia Core Complex [Cell Reports 7, (2014), 1849-1857]. Cell Reports. 14:2761-2763.
    189. LIG4 mediates Wnt signalling-induced radioresistance. Nature Communications. 7.
    190. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Molecular Systems Biology. 11.
    191. Defining the protein-protein interaction network of the human protein tyrosine phosphatase family. Molecular and Cellular Proteomics. 15:3030-3044.
    192. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle. 8:2933-2936.
    193. H1 provides the missing link. Cell Research. 26:5-6.
    194. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Reports. 15:843-856.
    195. Deubiquitylation and stabilization of PTEN by USP13. Nature Cell Biology.
    196. Association of BRCA1 with RAD51 in meiotic and mitotic cells. FASEB Journal. 11.
    197. DNA damage tolerance. Translational Cancer Research. 2:107-129.
    198. FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. Cell Reports. 16:487-497.
    199. DNA damage sensing and signaling. 1-22.
    200. NovoBreak. Nature Methods. 14:65-67.
    201. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes and Development. 27:116.
    202. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Molecular Cell.
    203. SLFN11 inhibits checkpoint maintenance and homologous recombination repair. EMBO Reports. 17:94-109.
    204. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nature Communications. 7.
    205. The 53BP1-expand1 connection in chromatin structure regulation. Nucleus. 1:1-3.
    206. Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins. Cell Reports. 13:524-532.
    207. Identification of KIAA1199 as a Biomarker for Pancreatic Intraepithelial Neoplasia. Scientific Reports. 6.
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