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JUNJIE CHEN

TitleProfessor
InstitutionMD Anderson
DepartmentExperimental Radiation Oncology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Res. 2015 May 1; 75(9):1846-58. PMID: 25877877.
      View in: PubMed
    2. Tian Y, Paramasivam M, Ghosal G, Chen D, Shen X, Huang Y, Akhter S, Legerski R, Chen J, Seidman MM, Qin J, Li L. UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold. Cell Rep. 2015 Mar 31; 10(12):1957-66. PMID: 25818288; PMCID: PMC4748712.
    3. Wang J, Chen J, Gong Z. TopBP1 stabilizes BLM protein to suppress sister chromatid exchange. Mol Cell. 2015 Mar 19; 57(6):955-6. PMID: 25794614.
      View in: PubMed
    4. Zhang P, Wang L, Rodriguez-Aguayo C, Yuan Y, Debeb BG, Chen D, Sun Y, You MJ, Liu Y, Dean DC, Woodward WA, Liang H, Yang X, Lopez-Berestein G, Sood AK, Hu Y, Ang KK, Chen J, Ma L. miR-205 acts as a tumour radiosensitizer by targeting ZEB1 and Ubc13. Nat Commun. 2014; 5:5671. PMID: 25476932; PMCID: PMC4377070.
    5. Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. J Cell Biol. 2014 Sep 29; 206(7):877-94. PMID: 25267294.
      View in: PubMed
    6. Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Mol Cell Proteomics. 2014 Nov; 13(11):2986-3000. PMID: 25096995.
      View in: PubMed
    7. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep; 16(9):864-75. PMID: 25086746; PMCID: PMC4150825.
    8. Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J. Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. J Cell Sci. 2014 May 1; 127(Pt 9):2029-39. PMID: 24569877; PMCID: PMC4004977.
    9. Li N, Chen J. ADP-ribosylation: activation, recognition, and removal. Mol Cells. 2014 Jan; 37(1):9-16. PMID: 24552704; PMCID: PMC3907000.
    10. Wang F, Cheng J, Liu D, Sun H, Zhao J, Wang J, Chen J, Su Y, Zou Z. P53-participated cellular and molecular responses to irradiation are cell differentiation-determined in murine intestinal epithelium. Arch Biochem Biophys. 2014 Jan 15; 542:21-7. PMID: 24315958.
      View in: PubMed
    11. Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec; 15(12):1486-94. PMID: 24270891; PMCID: PMC3951854.
    12. Wang J, Chen J, Gong Z. TopBP1 controls BLM protein level to maintain genome stability. Mol Cell. 2013 Dec 12; 52(5):667-78. PMID: 24239288.
      View in: PubMed
    13. Fong KW, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. Whole-genome screening identifies proteins localized to distinct nuclear bodies. J Cell Biol. 2013 Oct 14; 203(1):149-64. PMID: 24127217; PMCID: PMC3798253.
    14. Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J. Defining the protein-protein interaction network of the human hippo pathway. Mol Cell Proteomics. 2014 Jan; 13(1):119-31. PMID: 24126142; PMCID: PMC3879608.
    15. Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Res. 2013 Oct; 23(10):1215-28. PMID: 23999858; PMCID: PMC3790240.
    16. Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z. Akt regulates TPP1 homodimerization and telomere protection. Aging Cell. 2013 Dec; 12(6):1091-9. PMID: 23862686; PMCID: PMC4051222.
    17. Leung CC, Sun L, Gong Z, Burkat M, Edwards R, Assmus M, Chen J, Glover JN. Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure. 2013 Aug 6; 21(8):1450-9. PMID: 23891287; PMCID: PMC3760280.
    18. Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proc Natl Acad Sci U S A. 2013 Jun 25; 110(26):10640-5. PMID: 23754376; PMCID: PMC3696823.
    19. Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H. BRCA1 is a negative modulator of the PRC2 complex. EMBO J. 2013 May 29; 32(11):1584-97. PMID: 23624935.
      View in: PubMed
    20. Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. J Biol Chem. 2013 Apr 19; 288(16):11135-43. PMID: 23486525; PMCID: PMC3630874.
    21. Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Mol Cell. 2013 Mar 7; 49(5):997-1009. PMID: 23333308.
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    22. Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. J Biol Chem. 2013 Mar 1; 288(9):6342-50. PMID: 23329831; PMCID: PMC3585069.
    23. Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. J Cell Sci. 2013 Feb 1; 126(Pt 3):825-37. PMID: 23264731; PMCID: PMC3619811.
    24. Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes Dev. 2012 Dec 15; 26(24):2737-48. PMID: 23249736.
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    25. Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. J Biol Chem. 2013 Feb 1; 288(5):3174-83. PMID: 23229552.
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    26. Ghosal G, Chen J. Alteration/deficiency in activation 3 (ADA3): Regulator of DNA repair and genome stability. Cell Cycle. 2012 Dec 15; 11(24):4496. PMID: 23222062; PMCID: PMC3562290.
    27. Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. EMBO J. 2013 Jan 9; 32(1):126-39. PMID: 23178594; PMCID: PMC3545304.
    28. Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S. PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Res. 2013 Jan 1; 73(1):205-14. PMID: 23117887; PMCID: PMC3538077.
    29. Nadkarni A, Shrivastav M, Mladek AC, Schwingler PM, Grogan PT, Chen J, Sarkaria JN. ATM inhibitor KU-55933 increases the TMZ responsiveness of only inherently TMZ sensitive GBM cells. J Neurooncol. 2012 Dec; 110(3):349-57. PMID: 23054561; PMCID: PMC3535329.
    30. Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes Dev. 2012 Sep 1; 26(17):1959-71. PMID: 22948661; PMCID: PMC3435498.
    31. Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. J Biol Chem. 2012 Oct 5; 287(41):34225-33. PMID: 22902628; PMCID: PMC3464530.
    32. Fei J, Chen J. KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). J Biol Chem. 2012 Oct 12; 287(42):35118-26. PMID: 22902626.
      View in: PubMed
    33. Sorokin AV, Chen J. MEMO1, a new IRS1-interacting protein, induces epithelial-mesenchymal transition in mammary epithelial cells. Oncogene. 2013 Jun 27; 32(26):3130-8. PMID: 22824790.
      View in: PubMed
    34. Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Mol Cell. 2012 Aug 10; 47(3):410-21. PMID: 22705370; PMCID: PMC3601832.
    35. Wu J, Liu C, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. J Biol Chem. 2012 Jun 29; 287(27):22919-26. PMID: 22539352.
      View in: PubMed
    36. Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proc Natl Acad Sci U S A. 2012 Mar 20; 109(12):4491-6. PMID: 22396592.
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    37. Feng L, Chen J. The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nat Struct Mol Biol. 2012 Feb; 19(2):201-6. PMID: 22266820.
      View in: PubMed
    38. Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nat Struct Mol Biol. 2011 Dec; 18(12):1400-7. PMID: 22101936; PMCID: PMC3657743.
    39. Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J. RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. DNA Repair (Amst). 2012 Feb 1; 11(2):131-8. PMID: 22036607; PMCID: PMC3779126.
    40. Liu T, Wan L, Wu Y, Chen J, Huang J. hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. J Biol Chem. 2011 Dec 2; 286(48):41758-66. PMID: 21965664; PMCID: PMC3308884.
    41. Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS. Critical roles of ring finger protein RNF8 in replication stress responses. J Biol Chem. 2011 Jun 24; 286(25):22355-61. PMID: 21558560; PMCID: PMC3121383.
    42. Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J. WWP2 is an E3 ubiquitin ligase for PTEN. Nat Cell Biol. 2011 Jun; 13(6):728-33. PMID: 21532586; PMCID: PMC3926303.
    43. Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes Dev. 2011 May 1; 25(9):959-71. PMID: 21536735.
      View in: PubMed
    44. Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. EMBO Rep. 2011 Jun; 12(6):574-80. PMID: 21525954; PMCID: PMC3128281.
    45. Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. J Biol Chem. 2011 Jun 17; 286(24):21393-400. PMID: 21515671.
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    46. Gong Z, Chen J. E3 ligase RFWD3 participates in replication checkpoint control. J Biol Chem. 2011 Jun 24; 286(25):22308-13. PMID: 21504906; PMCID: PMC3121377.
    47. Wang J, Gong Z, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. J Cell Biol. 2011 Apr 18; 193(2):267-73. PMID: 21482717; PMCID: PMC3080258.
    48. Yuan J, Chen J. The role of the human SWI5-MEI5 complex in homologous recombination repair. J Biol Chem. 2011 Mar 18; 286(11):9888-93. PMID: 21252223; PMCID: PMC3059048.
    49. Wang W, Huang J, Chen J. Angiomotin-like proteins associate with and negatively regulate YAP1. J Biol Chem. 2011 Feb 11; 286(6):4364-70. PMID: 21187284.
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    50. Ting L, Jun H, Junjie C. RAD18 lives a double life: Its implication in DNA double-strand break repair. DNA Repair (Amst). 2010 Dec 10; 9(12):1241-8. PMID: 20971043.
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    51. Leung CC, Gong Z, Chen J, Glover JN. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. J Biol Chem. 2011 Feb 11; 286(6):4292-301. PMID: 21127055; PMCID: PMC3039391.
    52. Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nat Struct Mol Biol. 2010 Oct; 17(10):1255-9. PMID: 20871616.
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    53. Liu T, Ghosal G, Yuan J, Chen J, Huang J. FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science. 2010 Aug 6; 329(5992):693-6. PMID: 20671156.
      View in: PubMed
    54. Feng L, Wang J, Chen J. The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. J Biol Chem. 2010 Oct 1; 285(40):30982-8. PMID: 20656690; PMCID: PMC2945589.
    55. Sy SM, Chen J, Huen MS. The 53BP1-EXPAND1 connection in chromatin structure regulation. Nucleus. 2010 Nov-Dec; 1(6):472-4. PMID: 21327088; PMCID: PMC3027048.
    56. Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J. SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle. 2010 Jul 1; 9(13):2679-85. PMID: 20581448; PMCID: PMC3040851.
    57. Lim JH, Lee YM, Chun YS, Chen J, Kim JE, Park JW. Sirtuin 1 modulates cellular responses to hypoxia by deacetylating hypoxia-inducible factor 1alpha. Mol Cell. 2010 Jun 25; 38(6):864-78. PMID: 20620956.
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    58. Huen MS, Chen J. ATM Creates a veil of transcriptional silence. Cell. 2010 Jun 11; 141(6):924-6. PMID: 20550929.
      View in: PubMed
    59. Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: to be or not to be. FEBS Lett. 2010 Sep 10; 584(17):3717-24. PMID: 20493860.
      View in: PubMed
    60. Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. J Exp Med. 2010 May 10; 207(5):973-81. PMID: 20385748.
      View in: PubMed
    61. Park G, Gong Z, Chen J, Kim JE. Characterization of the DOT1L network: implications of diverse roles for DOT1L. Protein J. 2010 Apr; 29(3):213-23. PMID: 20431927.
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    62. Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Mol Cell. 2010 Mar 26; 37(6):854-64. PMID: 20347427.
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    63. Gong Z, Kim JE, Leung CC, Glover JN, Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Mol Cell. 2010 Feb 12; 37(3):438-46. PMID: 20159562; PMCID: PMC3695484.
    64. Wang J, Chen J. SIRT1 regulates autoacetylation and histone acetyltransferase activity of TIP60. J Biol Chem. 2010 Apr 9; 285(15):11458-64. PMID: 20100829; PMCID: PMC2857024.
    65. Escande C, Chini CC, Nin V, Dykhouse KM, Novak CM, Levine J, van Deursen J, Gores GJ, Chen J, Lou Z, Chini EN. Deleted in breast cancer-1 regulates SIRT1 activity and contributes to high-fat diet-induced liver steatosis in mice. J Clin Invest. 2010 Feb; 120(2):545-58. PMID: 20071779; PMCID: PMC2810074.
    66. Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nat Rev Mol Cell Biol. 2010 Feb; 11(2):138-48. PMID: 20029420.
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    67. Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF. CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Res. 2010 Mar; 38(5):1489-503. PMID: 20008512.
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    68. Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. J Mol Biol. 2010 Feb 5; 395(5):908-15. PMID: 19925808; PMCID: PMC2813331.
    69. Yuan J, Chen J. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. J Biol Chem. 2010 Jan 8; 285(2):1097-104. PMID: 19910469; PMCID: PMC2801237.
    70. Kim JE, Lou Z, Chen J. Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle. 2009 Nov 15; 8(22):3784-5. PMID: 19855164.
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    71. Huen MS, Chen J. Assembly of checkpoint and repair machineries at DNA damage sites. Trends Biochem Sci. 2010 Feb; 35(2):101-8. PMID: 19875294.
      View in: PubMed
    72. Ande SR, Chen J, Maddika S. The ubiquitin pathway: an emerging drug target in cancer therapy. Eur J Pharmacol. 2009 Dec 25; 625(1-3):199-205. PMID: 19835866.
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    73. Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes Dev. 2009 Oct 15; 23(20):2394-9. PMID: 19793864; PMCID: PMC2764499.
    74. Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. J Biol Chem. 2009 Nov 13; 284(46):31746-52. PMID: 19759395; PMCID: PMC2797245.
    75. Kim JE, Chen J, Lou Z. p30 DBC is a potential regulator of tumorigenesis. Cell Cycle. 2009 Sep 15; 8(18):2932-5. PMID: 19657230; PMCID: PMC2777512.
    76. Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Mol Cell. 2009 Aug 28; 35(4):534-41. PMID: 19716796.
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    77. Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. J Clin Invest. 2009 Sep; 119(9):2714-24. PMID: 19690386; PMCID: PMC2735912.
    78. Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Mol Cell. 2009 Aug 14; 35(3):384-93. PMID: 19683501; PMCID: PMC2756616.
    79. Sy SM, Huen MS, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. J Biol Chem. 2009 Aug 7; 284(32):21127-31. PMID: 19553677; PMCID: PMC2755835.
    80. Sy SM, Huen MS, Zhu Y, Chen J. PALB2 regulates recombinational repair through chromatin association and oligomerization. J Biol Chem. 2009 Jul 3; 284(27):18302-10. PMID: 19423707.
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    81. Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J. RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nat Cell Biol. 2009 May; 11(5):592-603. PMID: 19396164; PMCID: PMC2743127.
    82. Sy SM, Huen MS, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair. Proc Natl Acad Sci U S A. 2009 Apr 28; 106(17):7155-60. PMID: 19369211; PMCID: PMC2678481.
    83. Maddika S, Sy SM, Chen J. Functional interaction between Chfr and Kif22 controls genomic stability. J Biol Chem. 2009 May 8; 284(19):12998-3003. PMID: 19321445; PMCID: PMC2676032.
    84. Maddika S, Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nat Cell Biol. 2009 Apr; 11(4):409-19. PMID: 19287380; PMCID: PMC2754075.
    85. Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. J Biol Chem. 2009 Mar 13; 284(11):7284-93. PMID: 19124460.
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    86. Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nat Cell Biol. 2009 Feb; 11(2):204-10. PMID: 19098900; PMCID: PMC2712943.
    87. Huen MS, Chen J. When loose ends finally meet. Nat Struct Mol Biol. 2008 Dec; 15(12):1241-2. PMID: 19050718.
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    88. Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Mol Cell Biol. 2009 Feb; 29(3):849-60. PMID: 19015238.
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    89. Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. Aurora A is essential for early embryonic development and tumor suppression. J Biol Chem. 2008 Nov 14; 283(46):31785-90. PMID: 18801727; PMCID: PMC2581543.
    90. Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. Polo-like kinase 1 is essential for early embryonic development and tumor suppression. Mol Cell Biol. 2008 Nov; 28(22):6870-6. PMID: 18794363; PMCID: PMC2573299.
    91. Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nat Cell Biol. 2008 Sep; 10(9):1076-82. PMID: 19160488.
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    92. Wood JL, Chen J. DNA-damage checkpoints: location, location, location. Trends Cell Biol. 2008 Oct; 18(10):451-5. PMID: 18760607.
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    93. Wood JL, Liang Y, Li K, Chen J. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. J Biol Chem. 2008 Oct 24; 283(43):29586-92. PMID: 18718915; PMCID: PMC2570891.
    94. Huen MS, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly. Mol Cell Biol. 2008 Oct; 28(19):6104-12. PMID: 18678647; PMCID: PMC2547017.
    95. Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proc Natl Acad Sci U S A. 2008 Aug 12; 105(32):11200-5. PMID: 18678890; PMCID: PMC2516250.
    96. Wu L, Beito T, Chen J. Generation and characterization of novel monoclonal antibodies against human aurora-A. Hybridoma (Larchmt). 2008 Aug; 27(4):313-8. PMID: 18707550.
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    97. Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G. Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. J Mol Biol. 2008 Aug 29; 381(2):361-72. PMID: 18582474; PMCID: PMC2574983.
    98. Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. J Cell Biol. 2008 Jun 2; 181(5):727-35. PMID: 18504301; PMCID: PMC2396806.
    99. Kim H, Chen J. New players in the BRCA1-mediated DNA damage responsive pathway. Mol Cells. 2008 Jun 30; 25(4):457-61. PMID: 18443409.
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    100. Huang J, Chen J. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation. Oncogene. 2008 Jul 3; 27(29):4056-64. PMID: 18332868.
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    101. Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. J Biol Chem. 2008 Apr 25; 283(17):11073-7. PMID: 18319261; PMCID: PMC2431066.
    102. Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Mol Cell Biol. 2008 Apr; 28(8):2825-39. PMID: 18285465.
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    103. Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature. 2008 Jan 31; 451(7178):583-6. PMID: 18235501.
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    104. Huen MS, Chen J. The DNA damage response pathways: at the crossroad of protein modifications. Cell Res. 2008 Jan; 18(1):8-16. PMID: 18087291.
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    105. Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Mol Cell. 2007 Dec 28; 28(6):1045-57. PMID: 18158901.
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    107. Wood JL, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. J Biol Chem. 2007 Nov 30; 282(48):35416-23. PMID: 17925396; PMCID: PMC2128040.
    108. Kim H, Chen J. c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochem Biophys Res Commun. 2007 Nov 3; 362(4):842-7. PMID: 17765874; PMCID: PMC2047600.
    109. Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nat Struct Mol Biol. 2007 Aug; 14(8):710-5. PMID: 17643122.
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    110. Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science. 2007 May 25; 316(5828):1202-5. PMID: 17525342.
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    111. Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG. Differences in DNA double strand breaks repair in male germ cell types: lessons learned from a differential expression of Mdc1 and 53BP1. DNA Repair (Amst). 2007 Sep 1; 6(9):1243-54. PMID: 17376750.
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    112. Reina-San-Martin B, Chen J, Nussenzweig A, Nussenzweig MC. Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. Eur J Immunol. 2007 Jan; 37(1):235-9. PMID: 17183606.
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    113. Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 2006 Dec 29; 127(7):1361-73. PMID: 17190600; PMCID: PMC1804291.
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    115. Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science. 2006 Oct 13; 314(5797):294-7. PMID: 17038621.
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    116. Lai M, Chen J. The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function. Cell Cycle. 2006 Oct; 5(19):2275-80. PMID: 16969134.
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    117. Chini CC, Chen J. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. J Biol Chem. 2006 Nov 3; 281(44):33276-82. PMID: 16963448.
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    118. Wu X, Dong X, Liu W, Chen J. Characterization of CHEK2 mutations in prostate cancer. Hum Mutat. 2006 Aug; 27(8):742-7. PMID: 16835864.
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    120. Lou Z, Chen J. Cellular senescence and DNA repair. Exp Cell Res. 2006 Aug 15; 312(14):2641-6. PMID: 16893723.
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    122. Chini CC, Wood J, Chen J. Chk1 is required to maintain claspin stability. Oncogene. 2006 Jul 13; 25(30):4165-71. PMID: 16501606.
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    123. Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, Alt FW. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Mol Cell. 2006 Jan 20; 21(2):201-14. PMID: 16427010.
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    124. Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Mol Cell. 2006 Jan 20; 21(2):187-200. PMID: 16427009.
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    125. Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 2006 Mar 2; 440(7080):105-9. PMID: 16400328.
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    126. Lai M, Zimmerman ES, Planelles V, Chen J. Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. J Virol. 2005 Dec; 79(24):15443-51. PMID: 16306615; PMCID: PMC1315993.
    127. Kim JE, McAvoy SA, Smith DI, Chen J. Human TopBP1 ensures genome integrity during normal S phase. Mol Cell Biol. 2005 Dec; 25(24):10907-15. PMID: 16314514; PMCID: PMC1316943.
    128. Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice. Mol Cell Biol. 2005 Nov; 25(22):10079-86. PMID: 16260621.
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    129. Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint in cancer and aging: what have mice taught us? Curr Opin Cell Biol. 2005 Dec; 17(6):583-9. PMID: 16226453.
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    130. Karnitz LM, Flatten KS, Wagner JM, Loegering D, Hackbarth JS, Arlander SJ, Vroman BT, Thomas MB, Baek YU, Hopkins KM, Lieberman HB, Chen J, Cliby WA, Kaufmann SH. Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Mol Pharmacol. 2005 Dec; 68(6):1636-44. PMID: 16126823.
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    131. Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, Hutchison C, Chen J, Cao Y, Cheah KS, Tryggvason K, Zhou Z. Genomic instability in laminopathy-based premature aging. Nat Med. 2005 Jul; 11(7):780-5. PMID: 15980864.
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    132. Lou Z, Minter-Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nat Struct Mol Biol. 2005 Jul; 12(7):589-93. PMID: 15965487.
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    133. Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V. ATR and GADD45alpha mediate HIV-1 Vpr-induced apoptosis. Cell Death Differ. 2005 Apr; 12(4):326-34. PMID: 15650754.
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    134. Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J. Chfr is required for tumor suppression and Aurora A regulation. Nat Genet. 2005 Apr; 37(4):401-6. PMID: 15793587.
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    135. Ohashi A, Zdzienicka MZ, Chen J, Couch FJ. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. J Biol Chem. 2005 Apr 15; 280(15):14877-83. PMID: 15671039.
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    136. Lou Z, Chen J. Mammalian DNA damage response pathway. Adv Exp Med Biol. 2005; 570:425-55. PMID: 18727510.
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    137. Kim JE, Billadeau DD, Chen J. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. J Biol Chem. 2005 Feb 18; 280(7):5733-9. PMID: 15545273.
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    138. Yu X, Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Mol Cell Biol. 2004 Nov; 24(21):9478-86. PMID: 15485915.
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    139. Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V. Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Mol Cell Biol. 2004 Nov; 24(21):9286-94. PMID: 15485898.
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    140. Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J, Khanna K, Delia D. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene. 2004 Oct 7; 23(46):7691-700. PMID: 15361830.
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    141. Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. J Biol Chem. 2004 Nov 5; 279(45):46359-62. PMID: 15377652.
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    142. Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. J Cell Biol. 2004 Sep 13; 166(6):801-13. PMID: 15364958; PMCID: PMC2172115.
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    144. Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure. 2004 Jul; 12(7):1137-46. PMID: 15242590; PMCID: PMC3652423.
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    147. Ward I, Chen J. Early events in the DNA damage response. Curr Top Dev Biol. 2004; 63:1-35. PMID: 15536012.
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    148. Lou Z, Chen J. Use of siRNA to study the function of MDC1 in DNA damage responses. Methods Mol Biol. 2004; 281:179-87. PMID: 15220529.
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    151. Wu X, Chen J. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. J Biol Chem. 2003 Sep 19; 278(38):36163-8. PMID: 12855706.
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    152. Yamane K, Chen J, Kinsella TJ. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Res. 2003 Jun 15; 63(12):3049-53. PMID: 12810625.
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    153. Chini CC, Chen J. Human claspin is required for replication checkpoint control. J Biol Chem. 2003 Aug 8; 278(32):30057-62. PMID: 12766152.
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    154. Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. J Biol Chem. 2003 Aug 8; 278(32):30051-6. PMID: 12766176.
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    160. Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. J Biol Chem. 2002 Mar 8; 277(10):7849-56. PMID: 11751867.
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    163. Joukov V, Chen J, Fox EA, Green JB, Livingston DM. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proc Natl Acad Sci U S A. 2001 Oct 9; 98(21):12078-83. PMID: 11593018; PMCID: PMC59770.
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    171. Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Mol Cell Biol. 1998 May; 18(5):2758-67. PMID: 9566895; PMCID: PMC110655.
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