SHUNBIN XIONG

TitleAssistant Professor
InstitutionMD Anderson
DepartmentGenetics
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou X, Beilter A, Xu Z, Gao R, Xiong S, Paulucci-Holthauzen A, Lozano G, de Crombrugghe B, Gorlick R. Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells. Cell Death Dis. 2021 May 21; 12(6):521. PMID: 34021120.
      Citations:    Fields:    
    2. Kim MP, Li X, Deng J, Zhang Y, Dai B, Allton KL, Hughes TG, Siangco C, Augustine JJ, Kang Y, McDaniel JM, Xiong S, Koay EJ, McAllister F, Bristow CA, Heffernan TP, Maitra A, Liu B, Barton MC, Wasylishen AR, Fleming JB, Lozano G. Oncogenic KRAS recruits an expansive transcriptional network through mutant p53 to drive pancreatic cancer metastasis. Cancer Discov. 2021 Apr 10. PMID: 33839689.
      Citations:    Fields:    
    3. Pant V, Xiong S, Wasylishen AR, Larsson CA, Aryal NK, Chau G, Tailor RC, Lozano G. Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity. Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17429-17437. PMID: 31409715.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    4. Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nat Commun. 2018 09 27; 9(1):3953. PMID: 30262850.
      Citations: 9     Fields:    Translation:HumansAnimals
    5. Pourebrahim R, Zhang Y, Liu B, Gao R, Xiong S, Lin PP, McArthur MJ, Ostrowski MC, Lozano G. Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein. Genes Dev. 2017 09 15; 31(18):1847-1857. PMID: 29021240.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    6. Xiong S, Pant V, Zhang Y, Aryal NK, You MJ, Kusewitt D, Lozano G. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. J Pathol. 2017 03; 241(4):501-510. PMID: 27925213.
      Citations: 14     Fields:    Translation:HumansAnimals
    7. Tashakori M, Zhang Y, Xiong S, You MJ, Lozano G. p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis. Mol Cancer Res. 2016 Jan; 14(1):56-65. PMID: 26527653.
      Citations: 4     Fields:    Translation:Animals
    8. Xiong S, Mu T, Wang G, Jiang X. Mitochondria-mediated apoptosis in mammals. Protein Cell. 2014 Oct; 5(10):737-49. PMID: 25073422.
      Citations: 85     Fields:    Translation:HumansAnimalsCells
    9. Quintás-Cardama A, Post SM, Solis LM, Xiong S, Yang P, Chen N, Wistuba II, Killary AM, Lozano G. Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer. J Pathol. 2014 Sep; 234(1):108-19. PMID: 24890125.
      Citations: 10     Fields:    Translation:HumansAnimals
    10. Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11145-50. PMID: 25024203.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    11. Zhang Y, Xiong S, Li Q, Hu S, Tashakori M, Van Pelt C, You MJ, Pageon L, Lozano G. Tissue-specific and age-dependent effects of global Mdm2 loss. J Pathol. 2014 Aug; 233(4):380-91. PMID: 24789767.
      Citations: 20     Fields:    Translation:Animals
    12. Li Q, Zhang Y, El-Naggar AK, Xiong S, Yang P, Jackson JG, Chau G, Lozano G. Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors. Mol Cancer Res. 2014 Jun; 12(6):901-11. PMID: 24598047.
      Citations: 14     Fields:    Translation:AnimalsCells
    13. Pant V, Xiong S, Jackson JG, Post SM, Abbas HA, Quintás-Cardama A, Hamir AN, Lozano G. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev. 2013 Sep 01; 27(17):1857-67. PMID: 23973961.
      Citations: 41     Fields:    Translation:AnimalsCells
    14. Xiong S. Mouse models of Mdm2 and Mdm4 and their clinical implications. Chin J Cancer. 2013 Jul; 32(7):371-5. PMID: 23327795.
      Citations: 8     Fields:    Translation:Animals
    15. Xiong S, Parker-Thornburg J, Lozano G. Developing genetically engineered mouse models to study tumor suppression. Curr Protoc Mouse Biol. 2012 Mar 01; 2(1):9-24. PMID: 22582146.
      Citations:    Fields:    
    16. McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011 Aug 16; 20(2):260-75. PMID: 21840489.
      Citations: 64     Fields:    Translation:HumansAnimals
    17. Pant V, Xiong S, Iwakuma T, Quintás-Cardama A, Lozano G. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11995-2000. PMID: 21730132.
      Citations: 80     Fields:    Translation:AnimalsCells
    18. Wang Y, Suh YA, Fuller MY, Jackson JG, Xiong S, Terzian T, Quintás-Cardama A, Bankson JA, El-Naggar AK, Lozano G. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest. 2011 Mar; 121(3):893-904. PMID: 21285512.
      Citations: 66     Fields:    Translation:AnimalsCells
    19. Xiong S, Pant V, Suh YA, Van Pelt CS, Wang Y, Valentin-Vega YA, Post SM, Lozano G. Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4. Cancer Res. 2010 Sep 15; 70(18):7148-54. PMID: 20736370.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    20. Lin PP, Pandey MK, Jin F, Xiong S, Deavers M, Parant JM, Lozano G. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res. 2008 Nov 01; 68(21):8968-75. PMID: 18974141.
      Citations: 45     Fields:    Translation:AnimalsCells
    21. Liu G, Terzian T, Xiong S, Van Pelt CS, Audiffred A, Box NF, Lozano G. The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol. 2007 Dec; 213(4):360-8. PMID: 17893884.
      Citations: 34     Fields:    Translation:AnimalsCells
    22. Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation. 2007 Jun 12; 115(23):2925-30. PMID: 17533180.
      Citations: 40     Fields:    Translation:AnimalsCells
    23. Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3226-31. PMID: 16492743.
      Citations: 75     Fields:    Translation:Animals
    24. Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol. 2006 Jan; 26(1):192-8. PMID: 16354690.
      Citations: 81     Fields:    Translation:AnimalsCells
    25. Yao J, Xiong S, Klos K, Nguyen N, Grijalva R, Li P, Yu D. Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene. 2001 Dec 06; 20(56):8066-74. PMID: 11781819.
      Citations: 53     Fields:    Translation:HumansCells
    26. Xiong S, Grijalva R, Zhang L, Nguyen NT, Pisters PW, Pollock RE, Yu D. Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration. Cancer Res. 2001 Feb 15; 61(4):1727-32. PMID: 11245489.
      Citations: 21     Fields:    Translation:HumansCells
    27. Zhang L, Yu D, Hu M, Xiong S, Lang A, Ellis LM, Pollock RE. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res. 2000 Jul 01; 60(13):3655-61. PMID: 10910082.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    28. Xiong S, Chirala SS, Wakil SJ. Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):3948-53. PMID: 10759542.
      Citations: 22     Fields:    Translation:HumansCells
    29. Xiong S, Chirala SS, Hsu MH, Wakil SJ. Identification of thyroid hormone response elements in the human fatty acid synthase promoter. Proc Natl Acad Sci U S A. 1998 Oct 13; 95(21):12260-5. PMID: 9770474.
      Citations: 9     Fields:    Translation:HumansCells
    30. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. Journal of Pathology.
    31. MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response. Oncogene. 35:228-240.
    32. PLA2G16 expression in human osteosarcoma is associated with pulmonary metastasis and poor prognosis. PLoS One. 10.
    33. Coexpression of CXCR4 and MMP9 predicts lung metastasis and poor prognosis in resected osteosarcoma. Tumor Biology.
    34. Melatonin synergizes the chemotherapeutic effect of 5-fluorouracil in colon cancer by suppressing PI3K/AKT and NF-κB/iNOS signaling pathways. Journal of Pineal Research.
    35. p53 activity dominates that of p73 upon Mdm4 loss in development and tumorigenesis. Molecular Cancer Research. 14:56-65.
    36. Distinct downstream targets manifest p53-dependent pathologies in mice. Oncogene.
    37. The preparation of the antigen conformation-related monoclonal antibodies against maltose-binding protein. Acta Biochimica et Biophysica Sinica. 29:265.
    38. Identification of thyriod hormone response elements in human fatty acid synthase promoter. FASEB Journal. 11.
    39. PLA2G16 promotes osteosarcoma metastasis and drug resistance via the MAPK pathway. Oncotarget. 7:18021-18035.
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