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BALRAJ SINGH

TitleAssociate Professor
InstitutionMD Anderson
DepartmentBreast Surgical Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Singh B, Shamsnia A, Raythatha MR, Milligan RD, Cady AM, Madan S, Lucci A. Highly adaptable triple-negative breast cancer cells as a functional model for testing anticancer agents. PLoS One. 2014; 9(10):e109487. PMID: 25279830; PMCID: PMC4184880.
    2. Singh B, Tai K, Madan S, Raythatha MR, Cady AM, Braunlin M, Irving LR, Bajaj A, Lucci A. Selection of metastatic breast cancer cells based on adaptability of their metabolic state. PLoS One. 2012; 7(5):e36510. PMID: 22570721; PMCID: PMC3343010.
    3. Hall C, Krishnamurthy S, Lodhi A, Bhattacharyya A, Anderson A, Kuerer H, Bedrosian I, Singh B, Lucci A. Disseminated tumor cells predict survival after neoadjuvant therapy in primary breast cancer. Cancer. 2012 Jan 15; 118(2):342-8. PMID: 21717428.
      View in: PubMed
    4. Krishnamurthy S, Cristofanilli M, Singh B, Reuben J, Gao H, Cohen EN, Andreopoulou E, Hall CS, Lodhi A, Jackson S, Lucci A. Detection of minimal residual disease in blood and bone marrow in early stage breast cancer. Cancer. 2010 Jul 15; 116(14):3330-7. PMID: 20564098.
      View in: PubMed
    5. Singh B, Irving LR, Tai K, Lucci A. Overexpression of COX-2 in celecoxib-resistant breast cancer cell lines. J Surg Res. 2010 Oct; 163(2):235-43. PMID: 20691996; PMCID: PMC2943002.
    6. Singh B, Cook KR, Vincent L, Hall CS, Martin C, Lucci A. Role of COX-2 in tumorospheres derived from a breast cancer cell line. J Surg Res. 2011 Jun 1; 168(1):e39-49. PMID: 20462604; PMCID: PMC2921551.
    7. Singh B, Cook KR, Martin C, Huang EH, Mosalpuria K, Krishnamurthy S, Cristofanilli M, Lucci A. Evaluation of a CXCR4 antagonist in a xenograft mouse model of inflammatory breast cancer. Clin Exp Metastasis. 2010 Apr; 27(4):233-40. PMID: 20229045.
      View in: PubMed
    8. Zhang D, LaFortune TA, Krishnamurthy S, Esteva FJ, Cristofanilli M, Liu P, Lucci A, Singh B, Hung MC, Hortobagyi GN, Ueno NT. Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer. Clin Cancer Res. 2009 Nov 1; 15(21):6639-48. PMID: 19825949; PMCID: PMC2783487.
    9. Huang EH, Singh B, Cristofanilli M, Gelovani J, Wei C, Vincent L, Cook KR, Lucci A. A CXCR4 antagonist CTCE-9908 inhibits primary tumor growth and metastasis of breast cancer. J Surg Res. 2009 Aug; 155(2):231-6. PMID: 19482312.
      View in: PubMed
    10. Lucci A, Krishnamurthy S, Singh B, Bedrosian I, Meric-Bernstam F, Reuben J, Broglio K, Mosalpuria K, Lodhi A, Vincent L, Cristofanilli M. Cyclooxygenase-2 expression in primary breast cancers predicts dissemination of cancer cells to the bone marrow. Breast Cancer Res Treat. 2009 Sep; 117(1):61-8. PMID: 18663571.
      View in: PubMed
    11. Singh B, Cook KR, Vincent L, Hall CS, Berry JA, Multani AS, Lucci A. Cyclooxygenase-2 induces genomic instability, BCL2 expression, doxorubicin resistance, and altered cancer-initiating cell phenotype in MCF7 breast cancer cells. J Surg Res. 2008 Jun 15; 147(2):240-6. PMID: 18498876.
      View in: PubMed
    12. Lang JE, Mosalpuria K, Cristofanilli M, Krishnamurthy S, Reuben J, Singh B, Bedrosian I, Meric-Bernstam F, Lucci A. HER2 status predicts the presence of circulating tumor cells in patients with operable breast cancer. Breast Cancer Res Treat. 2009 Feb; 113(3):501-7. PMID: 18327638.
      View in: PubMed
    13. Lang JE, Hall CS, Singh B, Lucci A. Significance of micrometastasis in bone marrow and blood of operable breast cancer patients: research tool or clinical application? Expert Rev Anticancer Ther. 2007 Oct; 7(10):1463-72. PMID: 17944570.
      View in: PubMed
    14. Singh B, Vincent L, Berry JA, Multani AS, Lucci A. Cyclooxygenase-2 expression induces genomic instability in MCF10A breast epithelial cells. J Surg Res. 2007 Jun 15; 140(2):220-6. PMID: 17418864.
      View in: PubMed
    15. Singh B, Berry JA, Shoher A, Ayers GD, Wei C, Lucci A. COX-2 involvement in breast cancer metastasis to bone. Oncogene. 2007 May 31; 26(26):3789-96. PMID: 17213821.
      View in: PubMed
    16. Singh B, Berry JA, Vincent LE, Lucci A. Involvement of IL-8 in COX-2-mediated bone metastases from breast cancer. J Surg Res. 2006 Jul; 134(1):44-51. PMID: 16678856.
      View in: PubMed
    17. Singh B, Berry JA, Shoher A, Lucci A. COX-2 induces IL-11 production in human breast cancer cells. J Surg Res. 2006 Apr; 131(2):267-75. PMID: 16457848.
      View in: PubMed
    18. Singh B, Berry JA, Shoher A, Ramakrishnan V, Lucci A. COX-2 overexpression increases motility and invasion of breast cancer cells. Int J Oncol. 2005 May; 26(5):1393-9. PMID: 15809733.
      View in: PubMed
    19. Singh B, Lucci A. Role of cyclooxygenase-2 in breast cancer. J Surg Res. 2002 Nov; 108(1):173-9. PMID: 12472107.
      View in: PubMed
    20. Pham CD, Vuyyuru VB, Yang Y, Bai W, Singh B. Evidence for an important role of serine 16 and its phosphorylation in the stabilization of c-Mos. Oncogene. 1999 Jul 29; 18(30):4287-94. PMID: 10439036.
      View in: PubMed
    21. Liu H, Vuyyuru VB, Pham CD, Yang Y, Singh B. Evidence of an interaction between Mos and Hsp70: a role of the Mos residue serine 3 in mediating Hsp70 association. Oncogene. 1999 Jun 10; 18(23):3461-70. PMID: 10376524.
      View in: PubMed
    22. Ling YH, Yang Y, Tornos C, Singh B, Perez-Soler R. Paclitaxel-induced apoptosis is associated with expression and activation of c-Mos gene product in human ovarian carcinoma SKOV3 cells. Cancer Res. 1998 Aug 15; 58(16):3633-40. PMID: 9721872.
      View in: PubMed
    23. Yang Y, Pham CD, Vuyyuru VB, Liu H, Arlinghaus RB, Singh B. Evidence of a functional interaction between serine 3 and serine 25 Mos phosphorylation sites. A dominant inhibitory role of serine 25 phosphorylation on Mos protein kinase. J Biol Chem. 1998 Jun 26; 273(26):15946-53. PMID: 9632642.
      View in: PubMed
    24. Yang Y, Pham CD, Arlinghaus RB, Khillan JS, Singh B. Elevated level of cyclin D1 in mos-transformed cells. Int J Oncol. 1998 May; 12(5):1199-202. PMID: 9538150.
      View in: PubMed
    25. Tsui L, Ramagli L, Gao C, Pham C, Pandita T, Arlinghaus R, Singh B. The biological effects of antisense mos expression in fibroblasts. Int J Oncol. 1997 Dec; 11(6):1171-8. PMID: 21528318.
      View in: PubMed
    26. Singh B, Arlinghaus RB. Mos and the cell cycle. Prog Cell Cycle Res. 1997; 3:251-9. PMID: 9552420.
      View in: PubMed
    27. Gao C, Arlinghaus RB, Singh B. Further characterization of the c-mos transcript and its cell cycle specific expression in NIH3T3 cells. Oncogene. 1996 Apr 4; 12(7):1571-6. PMID: 8622874.
      View in: PubMed
    28. Yang Y, Herrmann CH, Arlinghaus RB, Singh B. Inhibition of v-Mos kinase activity by protein kinase A. Mol Cell Biol. 1996 Mar; 16(3):800-9. PMID: 8622681.
      View in: PubMed
    29. Lengye E, Singh B, Gum R, Nerlov C, Sabichi A, Birrer M, Boyd D. Regulation of urokinase-type plasminogen activator expression by the v-mos oncogene. Oncogene. 1995 Dec 21; 11(12):2639-48. PMID: 8545121.
      View in: PubMed
    30. Pham CD, Arlinghaus RB, Zheng CF, Guan KL, Singh B. Characterization of MEK1 phosphorylation by the v-Mos protein. Oncogene. 1995 Apr 20; 10(8):1683-8. PMID: 7731726.
      View in: PubMed
    31. Bai W, Arlinghaus RB, Singh B. Association of v-Mos with soluble vimentin in vitro and in transformed cells. Oncogene. 1993 Aug; 8(8):2207-12. PMID: 8336943.
      View in: PubMed
    32. Bai W, Singh B, Yang Y, Arlinghaus RB. Evidence for interaction between v-Mos and a p34cdc2 isoform, p35cdk. Oncogene. 1992 Sep; 7(9):1757-63. PMID: 1323818.
      View in: PubMed
    33. Bai W, Singh B, Yang Y, Ramagli LS, Nash M, Herzog NK, Arlinghaus RB. The physical interactions between p37env-mos and tubulin structures. Oncogene. 1992 Mar; 7(3):493-500. PMID: 1532247.
      View in: PubMed
    34. Singh B, Stocking C, Walker R, Yang YD, Ostertag W, Arlinghaus RB. v-mos proteins encoded by myeloproliferative sarcoma virus and its ts159 mutant. J Virol. 1992 Feb; 66(2):1267-72. PMID: 1309903.
      View in: PubMed
    35. Singh B, Arlinghaus RB. The mos proto-oncogene product: its role in oocyte maturation, metaphase arrest, and neoplastic transformation. Mol Carcinog. 1992; 6(3):182-9. PMID: 1332729.
      View in: PubMed
    36. Bai WL, Singh B, Karshin WL, Shonk RA, Arlinghaus RB. Phosphorylation of v-mos Ser 47 by the mitotic form of p34cdc2. Oncogene. 1991 Oct; 6(10):1715-23. PMID: 1833715.
      View in: PubMed
    37. Zhao X, Singh B, Arlinghaus RB. Inhibition of c-mos protein kinase blocks mouse zygotes at the pronuclei stage. Oncogene. 1991 Aug; 6(8):1423-6. PMID: 1832216.
      View in: PubMed
    38. Zhao X, Singh B, Batten BE. The role of c-mos proto-oncoprotein in mammalian meiotic maturation. Oncogene. 1991 Jan; 6(1):43-9. PMID: 1825139.
      View in: PubMed
    39. Zhao X, Batten B, Singh B, Arlinghaus RB. Requirement of the c-mos protein kinase for murine meiotic maturation. Oncogene. 1990 Nov; 5(11):1727-30. PMID: 2176285.
      View in: PubMed
    40. Singh B, al-Bagdadi F, Liu JX, Arlinghaus RB. Use of antipeptide antibodies to probe the catalytic activity of p37v-mos. Virology. 1990 Oct; 178(2):535-42. PMID: 2171192.
      View in: PubMed
    41. al-Bagdadi F, Singh B, Arlinghaus RB. Evidence for involvement of the protein kinase C pathway in the activation of p37v-mos protein kinase. Oncogene. 1990 Aug; 5(8):1251-7. PMID: 2168030.
      View in: PubMed
    42. Roy LM, Singh B, Gautier J, Arlinghaus RB, Nordeen SK, Maller JL. The cyclin B2 component of MPF is a substrate for the c-mos(xe) proto-oncogene product. Cell. 1990 Jun 1; 61(5):825-31. PMID: 2140529.
      View in: PubMed
    43. Hamelin R, Honore N, Sergiescu D, Singh B, Gerfaux J, Arlinghaus RB. Reversion of thermosensitive splicing defect of Moloney murine sarcoma virus ts110 by oversplicing of viral RNA. J Virol. 1990 Mar; 64(3):1378-82. PMID: 2154617; PMCID: PMC249261.
    44. Liu JX, Singh B, Wlodek D, Arlinghaus RB. Cell cycle-mediated structural and functional alteration of P85gag-mos protein kinase activity. Oncogene. 1990 Feb; 5(2):171-8. PMID: 2138725.
      View in: PubMed
    45. Singh B, Arlinghaus RB. Vimentin phosphorylation by p37mos protein kinase in vitro and generation of a 50-kDa cleavage product in v-mos-transformed cells. Virology. 1989 Nov; 173(1):144-56. PMID: 2554568.
      View in: PubMed
    46. Herzog NK, Singh B, Elder J, Lipkin I, Trauger RJ, Millette CF, Goldman DS, Wolfes H, Cooper GM, Arlinghaus RB. Identification of the protein product of the c-mos proto-oncogene in mouse testes. Oncogene. 1988 Aug; 3(2):225-9. PMID: 2970613.
      View in: PubMed
    47. Singh B, Wittenberg C, Hannink M, Reed SI, Donoghue DJ, Arlinghaus RB. The histidine-221 to tyrosine substitution in v-mos abolishes its biological function and its protein kinase activity. Virology. 1988 May; 164(1):114-20. PMID: 2966489.
      View in: PubMed
    48. Singh B, Goldman R, Hutton L, Herzog NK, Arlinghaus RB. The P55 protein affected by v-mos expression is vimentin. J Virol. 1987 Nov; 61(11):3625-9. PMID: 2822968; PMCID: PMC255966.
    49. Singh B, Hannink M, Donoghue DJ, Arlinghaus RB. p37mos-associated serine/threonine protein kinase activity correlates with the cellular transformation function of v-mos. J Virol. 1986 Dec; 60(3):1148-52. PMID: 3023666; PMCID: PMC253371.
    50. Escobedo J, Singh B, Dina D, Arlinghaus RB. Temperature-dependent cytocidal effects of Moloney murine sarcoma virus. Virus Res. 1986 Oct; 6(1):75-84. PMID: 3026112.
      View in: PubMed
    51. Singh B, Wittenberg C, Reed SI, Arlinghaus RB. Moloney murine sarcoma virus encoded p37mos expressed in yeast has protein kinase activity. Virology. 1986 Jul 30; 152(2):502-6. PMID: 3014729.
      View in: PubMed
    52. Singh B, Sparrow JT, Hedge AM, Arlinghaus RB. Expression of the v-mos gene alters a Mr 55,000 protein during acute infection by Moloney murine sarcoma virus. Proc Natl Acad Sci U S A. 1986 Jun; 83(11):3629-33. PMID: 3012522.
      View in: PubMed
    53. Gallick GE, Sparrow JT, Singh B, Maxwell SA, Stanker LH, Arlinghaus RB. Recognition of mos-related proteins with an antiserum to a peptide of the v-mos gene product. J Gen Virol. 1985 May; 66 ( Pt 5):945-55. PMID: 2987403.
      View in: PubMed
    54. Biswas M, Singh B, Rai YP, Datta A. Turnover of inducible N-acetylglucosamine catabolic enzymes in Candida albicans. Indian J Exp Biol. 1982 Nov; 20(11):829-34. PMID: 6762985.
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    55. Singh B, Thornton GB, Roy J, Talib S, De BP, Banerjee AK. Frequent intragenic transcription termination within the N gene of vesicular stomatitis virus. Virology. 1982 Oct 30; 122(2):239-50. PMID: 6293173.
      View in: PubMed
    56. Singh B, Guptaroy B, Hasan G, Datta A. Inhibitory effect of glucose and adenosine 3',5'-monophosphate on the synthesis of inducible N-acetylglucosamine catabolic enzymes in yeast. Biochim Biophys Acta. 1980 Oct 15; 632(3):345-53. PMID: 6251914.
      View in: PubMed
    57. Singh B, Biswas M, Datta A. Inducible N-acetyglucosamine-binding protein in yeasts. J Bacteriol. 1980 Oct; 144(1):1-6. PMID: 6998941.
      View in: PubMed
    58. Rai YP, Singh B, Elango N, Datta A. Purification and some properties of inducible N-acetylglucosamine kinase from Candida albicans. Biochim Biophys Acta. 1980 Aug 7; 614(2):350-6. PMID: 6250622.
      View in: PubMed
    59. Singh B, Datta A. Regulation of N-acetylglucosamine uptake in yeast. Biochim Biophys Acta. 1979 Oct 19; 557(1):248-58. PMID: 398716.
      View in: PubMed
    60. Biswas M, Singh B, Datta A. Induction of N-acetylmannosamine catabolic pathway in yeast. Biochim Biophys Acta. 1979 Jul 18; 585(4):535-42. PMID: 223651.
      View in: PubMed
    61. Singh B, Datta A. Regulation of glucosamine-6-phosphate deaminase synthesis in yeast. Biochim Biophys Acta. 1979 Feb 19; 583(1):28-35. PMID: 369615.
      View in: PubMed
    62. Singh B, Datta A. Induction of N-acetylglucosamine-catabolic pathway in spheroplasts of Candida albicans. Biochem J. 1979 Feb 15; 178(2):427-31. PMID: 220965; PMCID: PMC1186531.
    63. Singh BR, Datta A. Glucose repression of the inducible catabolic pathway for N-acetylglucosamine in yeast. Biochem Biophys Res Commun. 1978 Sep 14; 84(1):58-64. PMID: 215141.
      View in: PubMed
    64. Important role of FTO in the survival of rare panresistant triple-negative inflammatory breast cancer cells facing a severe metabolic challenge. PLoS One. 11.
    65. p37(mos) encoded by the HT-1 strain of Moloney murine sarcoma virus has an associated protein kinase activity. Oncogene. 3:79-85.
    66. Essential role of c-mos in eggs. International Journal of Gynecological Cancer. 7:314-317.
    67. Somatic cell expression of the mos proto-oncogene is cell cycle regulated. International Journal of Oncology. 2:493-502.
    68. Erratum. Journal of Surgical Research. 162:169.
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