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SANKAR N MAITY

TitleAssociate Professor
InstitutionMD Anderson
DepartmentGenitourinary Medical Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Lin SC, Lee YC, Yu G, Cheng CJ, Zhou X, Chu K, Murshed M, Le NT, Baseler L, Abe JI, Fujiwara K, deCrombrugghe B, Logothetis CJ, Gallick GE, Yu-Lee LY, Maity SN, Lin SH. Endothelial-to-Osteoblast Conversion Generates Osteoblastic Metastasis of Prostate Cancer. Dev Cell. 2017 Jun 05; 41(5):467-480.e3. PMID: 28586644.
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    2. Varkaris A, Corn PG, Parikh NU, Efstathiou E, Song JH, Lee YC, Aparicio A, Hoang AG, Gaur S, Thorpe L, Maity SN, Bar Eli M, Czerniak BA, Shao Y, Alauddin M, Lin SH, Logothetis CJ, Gallick GE. Integrating Murine and Clinical Trials with Cabozantinib to Understand Roles of MET and VEGFR2 as Targets for Growth Inhibition of Prostate Cancer. Clin Cancer Res. 2016 Jan 1; 22(1):107-21. PMID: 26272062.
      View in: PubMed
    3. Shi Z, Chiang CI, Labhart P, Zhao Y, Yang J, Mistretta TA, Henning SJ, Maity SN, Mori-Akiyama Y. Context-specific role of SOX9 in NF-Y mediated gene regulation in colorectal cancer cells. Nucleic Acids Res. 2015 Jul 27; 43(13):6257-69. PMID: 26040697.
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    4. Lee YC, Gajdosik MS, Josic D, Clifton JG, Logothetis C, Yu-Lee LY, Gallick GE, Maity SN, Lin SH. Secretome analysis of an osteogenic prostate tumor identifies complex signaling networks mediating cross-talk of cancer and stromal cells within the tumor microenvironment. Mol Cell Proteomics. 2015 Mar; 14(3):471-83. PMID: 25527621; PMCID: PMC4349970.
    5. Mitani Y, Rao PH, Maity SN, Lee YC, Ferrarotto R, Post JC, Licitra L, Lippman SM, Kies MS, Weber RS, Caulin C, Lin SH, El-Naggar AK. Alterations associated with androgen receptor gene activation in salivary duct carcinoma of both sexes: potential therapeutic ramifications. Clin Cancer Res. 2014 Dec 15; 20(24):6570-81. PMID: 25316813; PMCID: PMC4268116.
    6. Li L, Chang W, Yang G, Ren C, Park S, Karantanos T, Karanika S, Wang J, Yin J, Shah PK, Takahiro H, Dobashi M, Zhang W, Efstathiou E, Maity SN, Aparicio AM, Li Ning Tapia EM, Troncoso P, Broom B, Xiao L, Lee HS, Lee JS, Corn PG, Navone N, Thompson TC. Targeting poly(ADP-ribose) polymerase and the c-Myb-regulated DNA damage response pathway in castration-resistant prostate cancer. Sci Signal. 2014 May 20; 7(326):ra47. PMID: 24847116.
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    7. Yamanaka T, Tosaki A, Kurosawa M, Matsumoto G, Koike M, Uchiyama Y, Maity SN, Shimogori T, Hattori N, Nukina N. NF-Y inactivation causes atypical neurodegeneration characterized by ubiquitin and p62 accumulation and endoplasmic reticulum disorganization. Nat Commun. 2014; 5:3354. PMID: 24566496.
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    8. Logothetis CJ, Gallick GE, Maity SN, Kim J, Aparicio A, Efstathiou E, Lin SH. Molecular classification of prostate cancer progression: foundation for marker-driven treatment of prostate cancer. Cancer Discov. 2013 Aug; 3(8):849-61. PMID: 23811619; PMCID: PMC3926428.
    9. Dayyani F, Parikh NU, Varkaris AS, Song JH, Moorthy S, Chatterji T, Maity SN, Wolfe AR, Carboni JM, Gottardis MM, Logothetis CJ, Gallick GE. Combined Inhibition of IGF-1R/IR and Src family kinases enhances antitumor effects in prostate cancer by decreasing activated survival pathways. PLoS One. 2012; 7(12):e51189. PMID: 23300537; PMCID: PMC3530555.
    10. Efstathiou E, Karlou M, Wen S, Hoang A, Pettaway CA, Pisters LL, Maity S, Troncoso P, Logothetis CJ. Integrated Hedgehog signaling is induced following castration in human and murine prostate cancers. Prostate. 2013 Jan; 73(2):153-61. PMID: 22753310; PMCID: PMC3878994.
    11. Karlou M, Lu JF, Wu G, Maity S, Tzelepi V, Navone NM, Hoang A, Logothetis CJ, Efstathiou E. Hedgehog signaling inhibition by the small molecule smoothened inhibitor GDC-0449 in the bone forming prostate cancer xenograft MDA PCa 118b. Prostate. 2012 Nov; 72(15):1638-47. PMID: 22457212.
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    12. Wan X, Liu J, Lu JF, Tzelepi V, Yang J, Starbuck MW, Diao L, Wang J, Efstathiou E, Vazquez ES, Troncoso P, Maity SN, Navone NM. Activation of ?-catenin signaling in androgen receptor-negative prostate cancer cells. Clin Cancer Res. 2012 Feb 1; 18(3):726-36. PMID: 22298898; PMCID: PMC3271798.
    13. Li J, Ding Z, Wang Z, Lu JF, Maity SN, Navone NM, Logothetis CJ, Mills GB, Kim J. Androgen regulation of 5?-reductase isoenzymes in prostate cancer: implications for prostate cancer prevention. PLoS One. 2011; 6(12):e28840. PMID: 22194926; PMCID: PMC3237548.
    14. Tzelepi V, Zhang J, Lu JF, Kleb B, Wu G, Wan X, Hoang A, Efstathiou E, Sircar K, Navone NM, Troncoso P, Liang S, Logothetis CJ, Maity SN, Aparicio AM. Modeling a lethal prostate cancer variant with small-cell carcinoma features. Clin Cancer Res. 2012 Feb 1; 18(3):666-77. PMID: 22156612; PMCID: PMC3923417.
    15. Luo R, Klumpp SA, Finegold MJ, Maity SN. Inactivation of CBF/NF-Y in postnatal liver causes hepatocellular degeneration, lipid deposition, and endoplasmic reticulum stress. Sci Rep. 2011; 1:136. PMID: 22355653; PMCID: PMC3216617.
    16. Aparicio A, Logothetis CJ, Maity SN. Understanding the lethal variant of prostate cancer: power of examining extremes. Cancer Discov. 2011 Nov; 1(6):466-8. PMID: 22586648.
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    17. Lee YC, Cheng CJ, Bilen MA, Lu JF, Satcher RL, Yu-Lee LY, Gallick GE, Maity SN, Lin SH. BMP4 promotes prostate tumor growth in bone through osteogenesis. Cancer Res. 2011 Aug 1; 71(15):5194-203. PMID: 21670081; PMCID: PMC3148283.
    18. Aparicio A, Tzelepi V, Araujo JC, Guo CC, Liang S, Troncoso P, Logothetis CJ, Navone NM, Maity SN. Neuroendocrine prostate cancer xenografts with large-cell and small-cell features derived from a single patient's tumor: morphological, immunohistochemical, and gene expression profiles. Prostate. 2011 Jun 1; 71(8):846-56. PMID: 21456067; PMCID: PMC3883511.
    19. Gorlov IP, Sircar K, Zhao H, Maity SN, Navone NM, Gorlova OY, Troncoso P, Pettaway CA, Byun JY, Logothetis CJ. Prioritizing genes associated with prostate cancer development. BMC Cancer. 2010; 10:599. PMID: 21044312; PMCID: PMC2988752.
    20. Coustry F, Oh CD, Hattori T, Maity SN, de Crombrugghe B, Yasuda H. The dimerization domain of SOX9 is required for transcription activation of a chondrocyte-specific chromatin DNA template. Nucleic Acids Res. 2010 Oct; 38(18):6018-28. PMID: 20484372.
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    21. Oh CD, Maity SN, Lu JF, Zhang J, Liang S, Coustry F, de Crombrugghe B, Yasuda H. Identification of SOX9 interaction sites in the genome of chondrocytes. PLoS One. 2010; 5(4):e10113. PMID: 20404928.
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    22. Luo R, Lu JF, Hu Q, Maity SN. CBF/NF-Y controls endoplasmic reticulum stress induced transcription through recruitment of both ATF6(N) and TBP. J Cell Biochem. 2008 Aug 1; 104(5):1708-23. PMID: 18348279.
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    23. Li ZG, Mathew P, Yang J, Starbuck MW, Zurita AJ, Liu J, Sikes C, Multani AS, Efstathiou E, Lopez A, Wang J, Fanning TV, Prieto VG, Kundra V, Vazquez ES, Troncoso P, Raymond AK, Logothetis CJ, Lin SH, Maity S, Navone NM. Androgen receptor-negative human prostate cancer cells induce osteogenesis in mice through FGF9-mediated mechanisms. J Clin Invest. 2008 Aug; 118(8):2697-710. PMID: 18618013; PMCID: PMC2447924.
    24. Hu Q, Lu JF, Luo R, Sen S, Maity SN. Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle. Nucleic Acids Res. 2006; 34(21):6272-85. PMID: 17098936; PMCID: PMC1693888.
    25. Chattopadhyay C, Hawke D, Kobayashi R, Maity SN. Human p32, interacts with B subunit of the CCAAT-binding factor, CBF/NF-Y, and inhibits CBF-mediated transcription activation in vitro. Nucleic Acids Res. 2004; 32(12):3632-41. PMID: 15243141.
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    26. Bhattacharya A, Deng JM, Zhang Z, Behringer R, de Crombrugghe B, Maity SN. The B subunit of the CCAAT box binding transcription factor complex (CBF/NF-Y) is essential for early mouse development and cell proliferation. Cancer Res. 2003 Dec 1; 63(23):8167-72. PMID: 14678971.
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    27. Hu Q, Bhattacharya C, Maity SN. CCAAT binding factor (CBF) binding mediates cell cycle activation of topoisomerase IIalpha. Conventional CBF activation domains are not required. J Biol Chem. 2002 Oct 4; 277(40):37191-200. PMID: 12149265.
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    28. Li X, Bhattacharya C, Dayal S, Maity S, Klein WH. Ectoderm gene activation in sea urchin embryos mediated by the CCAAT-binding factor. Differentiation. 2002 May; 70(2-3):109-19. PMID: 12076338.
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    29. Coustry F, Hu Q, de Crombrugghe B, Maity SN. CBF/NF-Y functions both in nucleosomal disruption and transcription activation of the chromatin-assembled topoisomerase IIalpha promoter. Transcription activation by CBF/NF-Y in chromatin is dependent on the promoter structure. J Biol Chem. 2001 Nov 2; 276(44):40621-30. PMID: 11514576.
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    30. Zhu XS, Linhoff MW, Li G, Chin KC, Maity SN, Ting JP. Transcriptional scaffold: CIITA interacts with NF-Y, RFX, and CREB to cause stereospecific regulation of the class II major histocompatibility complex promoter. Mol Cell Biol. 2000 Aug; 20(16):6051-61. PMID: 10913187.
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    31. Hu Q, Maity SN. Stable expression of a dominant negative mutant of CCAAT binding factor/NF-Y in mouse fibroblast cells resulting in retardation of cell growth and inhibition of transcription of various cellular genes. J Biol Chem. 2000 Feb 11; 275(6):4435-44. PMID: 10660616.
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    32. Faniello MC, Bevilacqua MA, Condorelli G, de Crombrugghe B, Maity SN, Avvedimento VE, Cimino F, Costanzo F. The B subunit of the CAAT-binding factor NFY binds the central segment of the Co-activator p300. J Biol Chem. 1999 Mar 19; 274(12):7623-6. PMID: 10075648.
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    33. Liang SG, Maity SN. Pathway of complex formation between DNA and three subunits of CBF/NF-Y. Photocross-linking analysis of DNA-protein interaction and characterization of equilibrium steps of subunit interaction and dna binding. J Biol Chem. 1998 Nov 20; 273(47):31590-8. PMID: 9813075.
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    34. Maity SN, de Crombrugghe B. Role of the CCAAT-binding protein CBF/NF-Y in transcription. Trends Biochem Sci. 1998 May; 23(5):174-8. PMID: 9612081.
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    35. Coustry F, Sinha S, Maity SN, Crombrugghe B. The two activation domains of the CCAAT-binding factor CBF interact with the dTAFII110 component of the Drosophila TFIID complex. Biochem J. 1998 Apr 1; 331 ( Pt 1):291-7. PMID: 9512492; PMCID: PMC1219351.
    36. Bi W, Wu L, Coustry F, de Crombrugghe B, Maity SN. DNA binding specificity of the CCAAT-binding factor CBF/NF-Y. J Biol Chem. 1997 Oct 17; 272(42):26562-72. PMID: 9334236.
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    37. Chen SS, Ruteshouser EC, Maity SN, de Crombrugghe B. Cell-specific in vivo DNA-protein interactions at the proximal promoters of the pro alpha 1(I) and the pro alpha2(I) collagen genes. Nucleic Acids Res. 1997 Aug 15; 25(16):3261-8. PMID: 9241239; PMCID: PMC146878.
    38. Sinha S, Maity SN, Seldin MF, de Crombrugghe B. Chromosomal assignment and tissue expression of CBF-C/NFY-C, the third subunit of the mammalian CCAAT-binding factor. Genomics. 1996 Oct 15; 37(2):260-3. PMID: 8921405.
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    39. Hasegawa T, Zhou X, Garrett LA, Ruteshouser EC, Maity SN, de Crombrugghe B. Evidence for three major transcription activation elements in the proximal mouse proalpha2(I) collagen promoter. Nucleic Acids Res. 1996 Aug 15; 24(16):3253-60. PMID: 8774909; PMCID: PMC146084.
    40. Kim IS, Sinha S, de Crombrugghe B, Maity SN. Determination of functional domains in the C subunit of the CCAAT-binding factor (CBF) necessary for formation of a CBF-DNA complex: CBF-B interacts simultaneously with both the CBF-A and CBF-C subunits to form a heterotrimeric CBF molecule. Mol Cell Biol. 1996 Aug; 16(8):4003-13. PMID: 8754798; PMCID: PMC231396.
    41. Lefebvre V, Zhou G, Mukhopadhyay K, Smith CN, Zhang Z, Eberspaecher H, Zhou X, Sinha S, Maity SN, de Crombrugghe B. An 18-base-pair sequence in the mouse proalpha1(II) collagen gene is sufficient for expression in cartilage and binds nuclear proteins that are selectively expressed in chondrocytes. Mol Cell Biol. 1996 Aug; 16(8):4512-23. PMID: 8754852.
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    42. Coustry F, Maity SN, Sinha S, de Crombrugghe B. The transcriptional activity of the CCAAT-binding factor CBF is mediated by two distinct activation domains, one in the CBF-B subunit and the other in the CBF-C subunit. J Biol Chem. 1996 Jun 14; 271(24):14485-91. PMID: 8662945.
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    43. Maity SN, De Crombrugghe B. Purification, characterization, and role of CCAAT-binding factor in transcription. Methods Enzymol. 1996; 273:217-32. PMID: 8791615.
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    44. Sinha S, Kim IS, Sohn KY, de Crombrugghe B, Maity SN. Three classes of mutations in the A subunit of the CCAAT-binding factor CBF delineate functional domains involved in the three-step assembly of the CBF-DNA complex. Mol Cell Biol. 1996 Jan; 16(1):328-37. PMID: 8524312; PMCID: PMC231007.
    45. Sinha S, Maity SN, Lu J, de Crombrugghe B. Recombinant rat CBF-C, the third subunit of CBF/NFY, allows formation of a protein-DNA complex with CBF-A and CBF-B and with yeast HAP2 and HAP3. Proc Natl Acad Sci U S A. 1995 Feb 28; 92(5):1624-8. PMID: 7878029; PMCID: PMC42572.
    46. Coustry F, Maity SN, de Crombrugghe B. Studies on transcription activation by the multimeric CCAAT-binding factor CBF. J Biol Chem. 1995 Jan 6; 270(1):468-75. PMID: 7814413.
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    47. Sohn KY, Maity SN, de Crombrugghe B. Studies on the structure of the mouse CBF-A gene and properties of a truncated CBF-A isoform generated from an alternatively spliced RNA. Gene. 1994 Feb 25; 139(2):147-53. PMID: 7509302.
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    48. Goldberg H, Helaakoski T, Garrett LA, Karsenty G, Pellegrino A, Lozano G, Maity S, de Crombrugghe B. Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem. 1992 Sep 25; 267(27):19622-30. PMID: 1527081.
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    49. Maity SN, Sinha S, Ruteshouser EC, de Crombrugghe B. Three different polypeptides are necessary for DNA binding of the mammalian heteromeric CCAAT binding factor. J Biol Chem. 1992 Aug 15; 267(23):16574-80. PMID: 1644837.
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    50. Maity SN, de Crombrugghe B. Biochemical analysis of the B subunit of the heteromeric CCAAT-binding factor. A DNA-binding domain and a subunit interaction domain are specified by two separate segments. J Biol Chem. 1992 Apr 25; 267(12):8286-92. PMID: 1569083.
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    51. de Crombrugghe B, Vuorio T, Karsenty G, Maity S, Rutheshouser EC, Goldberg H. Transcriptional control mechanisms for the expression of type I collagen genes. Ann Rheum Dis. 1991 Nov; 50 Suppl 4:872-6. PMID: 1750800; PMCID: PMC1033323.
    52. Vuorio T, Maity SN, de Crombrugghe B. Purification and molecular cloning of the "A" chain of a rat heteromeric CCAAT-binding protein. Sequence identity with the yeast HAP3 transcription factor. J Biol Chem. 1990 Dec 25; 265(36):22480-6. PMID: 2266139.
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    53. Maity SN, Vuorio T, de Crombrugghe B. The B subunit of a rat heteromeric CCAAT-binding transcription factor shows a striking sequence identity with the yeast Hap2 transcription factor. Proc Natl Acad Sci U S A. 1990 Jul; 87(14):5378-82. PMID: 2196566; PMCID: PMC54327.
    54. De Crombrugghe B, Karsenty G, Maity S, Vuorio T, Rossi P, Ruteshouser EC, McKinney SH, Lozano G. Transcriptional mechanisms controlling types I and III collagen genes. Ann N Y Acad Sci. 1990; 580:88-96. PMID: 2337308.
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    55. Maity SN, Ray K, Banerjee A, Mukhopadhyay K, Roychowdhury S, Chaudhuri GG, Biswas BB, Bhattacharyya B. Role of B-ring of colchicine in its binding to tubulin. Indian J Biochem Biophys. 1988 Dec; 25(6):585-9. PMID: 3255673.
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    56. Maity SN, Golumbek PT, Karsenty G, de Crombrugghe B. Selective activation of transcription by a novel CCAAT binding factor. Science. 1988 Jul 29; 241(4865):582-5. PMID: 3399893.
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    57. Maity SN, Bhattacharyya B. Properties of B-ring analogues of colchicine. FEBS Lett. 1987 Jun 22; 218(1):102-6. PMID: 3595855.
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    58. Bhattacharyya B, Howard R, Maity SN, Brossi A, Sharma PN, Wolff J. B ring regulation of colchicine binding kinetics and fluorescence. Proc Natl Acad Sci U S A. 1986 Apr; 83(7):2052-5. PMID: 3457374.
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    59. Ghosh Choudhury G, Maity S, Bhattacharyya B, Biswas BB. B-ring of colchicine and its role in taxol-induced tubulin polymerization. FEBS Lett. 1986 Mar 3; 197(1-2):31-4. PMID: 2868923.
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    60. Bhattacharyya B, Ghoshchaudhuri G, Maity S, Biswas BB. The role of the B-ring of colchicine on taxol-induced tubulin polymerization. Ann N Y Acad Sci. 1986; 466:791-3. PMID: 2873782.
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    61. Differential roles of NF-Y transcription factor in ER chaperone expression and neuronal maintenance in the CNS. Scientific Reports. 6.
    62. Differentially methylated genes and androgen receptor re-expression in small cell prostate carcinomas. Epigenetics. 1-10.
    63. A CCAAT-binding factor NF-Y involved in transcription of human ROD transducin α-subunit (GNAT1) gene. Investigative Ophthalmology and Visual Science. 38.
    64. Combined tumor suppressor defects characterize clinically defined aggressive variant prostate cancers. Clinical Cancer Research. 22:1520-1530.
    65. NF-Y (CBF) regulation in specific cell types and mouse models. Biochimica et Biophysica Acta - Gene Regulatory Mechanisms.
    66. Integrating murine and clinical trials with cabozantinib to understand roles of MET and VEGFR2 as targets for growth inhibition of prostate cancer. Clinical Cancer Research. 22:107-121.
    67. Role of B-ring of colchicine in its binding to Zn(II)-induced tubulin-sheets. Journal of Biosciences. 11:525-536.
    68. Inhibition of FOXC2 restores epithelial phenotype and drug sensitivity in prostate cancer cells with stem-cell properties. Oncogene.
    69. Targeting of CYP17A1 Lyase by VT-464 Inhibits Adrenal and Intratumoral Androgen Biosynthesis and Tumor Growth of Castration Resistant Prostate Cancer. Scientific Reports. 6.
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