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JIAN KUANG

TitleAssociate Professor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Chatterji T, Varkaris AS, Parikh NU, Song JH, Cheng CJ, Schweppe RE, Alexander S, Davis JW, Troncoso P, Friedl P, Kuang J, Lin SH, Gallick GE. Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells. Oncotarget. 2015 Apr 30; 6(12):10175-94. PMID: 25868388.
      View in: PubMed
    2. Li SJ, Hua ZS, Huang LN, Li J, Shi SH, Chen LX, Kuang JL, Liu J, Hu M, Shu WS. Microbial communities evolve faster in extreme environments. Sci Rep. 2014; 4:6205. PMID: 25158668.
      View in: PubMed
    3. Zhang B, Wang O, Qin J, Liu S, Sun S, Liu H, Kuang J, Jiang G, Zhang W. cis-Acting elements and trans-acting factors in the transcriptional regulation of raf kinase inhibitory protein expression. PLoS One. 2013; 8(12):e83097. PMID: 24386147; PMCID: PMC3873293.
    4. He G, Kuang J, Koomen J, Kobayashi R, Khokhar AR, Siddik ZH. Recruitment of trimeric proliferating cell nuclear antigen by G1-phase cyclin-dependent kinases following DNA damage with platinum-based antitumour agents. Br J Cancer. 2013 Oct 29; 109(9):2378-88. PMID: 24104967; PMCID: PMC3817341.
    5. Lee YC, Bilen MA, Yu G, Lin SC, Huang CF, Ortiz A, Cho H, Song JH, Satcher RL, Kuang J, Gallick GE, Yu-Lee LY, Huang W, Lin SH. Inhibition of cell adhesion by a cadherin-11 antibody thwarts bone metastasis. Mol Cancer Res. 2013 Nov; 11(11):1401-11. PMID: 23913163; PMCID: PMC3834228.
    6. Wu CF, Liu S, Lee YC, Wang R, Sun S, Yin F, Bornmann WG, Yu-Lee LY, Gallick GE, Zhang W, Lin SH, Kuang J. RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B. Oncogene. 2014 May 1; 33(18):2385-94. PMID: 23708659; PMCID: PMC4026278.
    7. Zhang S, Mercado-Uribe I, Xing Z, Sun B, Kuang J, Liu J. Generation of cancer stem-like cells through the formation of polyploid giant cancer cells. Oncogene. 2014 Jan 2; 33(1):116-28. PMID: 23524583.
      View in: PubMed
    8. Zhang X, Cao Q, Liu X, Liu S, Wang J, Sun S, Wang O, Tian Z, Liu H, Kuang J, Zhang W. Cellular and molecular evidence for malignancy-inhibitory functions of p15RS. Cell Cycle. 2012 May 15; 11(10):1988-98. PMID: 22580456.
      View in: PubMed
    9. Wang JN, Kuang JF, Shan W, Chen J, Xie H, Lu WJ, Chen JW, Chen JY. Expression profiles of a banana fruit linker histone H1 gene MaHIS1 and its interaction with a WRKY transcription factor. Plant Cell Rep. 2012 Aug; 31(8):1485-94. PMID: 22527195.
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    10. Chen J, Chen JY, Wang JN, Kuang JF, Shan W, Lu WJ. Molecular characterization and expression profiles of MaCOL1, a CONSTANS-like gene in banana fruit. Gene. 2012 Apr 1; 496(2):110-7. PMID: 22285923.
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    11. Chen JY, Liu DJ, Jiang YM, Zhao ML, Shan W, Kuang JF, Lu WJ. Molecular characterization of a strawberry FaASR gene in relation to fruit ripening. PLoS One. 2011; 6(9):e24649. PMID: 21915355.
      View in: PubMed
    12. He G, Kuang J, Khokhar AR, Siddik ZH. The impact of S- and G2-checkpoint response on the fidelity of G1-arrest by cisplatin and its comparison to a non-cross-resistant platinum(IV) analog. Gynecol Oncol. 2011 Aug; 122(2):402-9. PMID: 21592546; PMCID: PMC3601787.
    13. Zhou X, Si J, Corvera J, Gallick GE, Kuang J. Decoding the intrinsic mechanism that prohibits ALIX interaction with ESCRT and viral proteins. Biochem J. 2010 Dec 15; 432(3):525-34. PMID: 20929444; PMCID: PMC4391464.
    14. Wang R, Jung SY, Wu CF, Qin J, Kobayashi R, Gallick GE, Kuang J. Direct roles of the signaling kinase RSK2 in Cdc25C activation during Xenopus oocyte maturation. Proc Natl Acad Sci U S A. 2010 Nov 16; 107(46):19885-90. PMID: 21041626; PMCID: PMC2993414.
    15. Ji P, Smith SM, Wang Y, Jiang R, Song SW, Li B, Sawaya R, Bruner JM, Kuang J, Yu H, Fuller GN, Zhang W. Inhibition of gliomagenesis and attenuation of mitotic transition by MIIP. Oncogene. 2010 Jun 17; 29(24):3501-8. PMID: 20418911.
      View in: PubMed
    16. Wu CF, Wang R, Liang Q, Liang J, Li W, Jung SY, Qin J, Lin SH, Kuang J. Dissecting the M phase-specific phosphorylation of serine-proline or threonine-proline motifs. Mol Biol Cell. 2010 May 1; 21(9):1470-81. PMID: 20219976; PMCID: PMC2861607.
    17. Zhou X, Pan S, Sun L, Corvera J, Lee YC, Lin SH, Kuang J. The CHMP4b- and Src-docking sites in the Bro1 domain are autoinhibited in the native state of Alix. Biochem J. 2009 Mar 1; 418(2):277-84. PMID: 19016654.
      View in: PubMed
    18. Zhou X, Pan S, Sun L, Corvera J, Lin SH, Kuang J. The HIV-1 p6/EIAV p9 docking site in Alix is autoinhibited as revealed by a conformation-sensitive anti-Alix monoclonal antibody. Biochem J. 2008 Sep 1; 414(2):215-20. PMID: 18476810.
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    19. Pan S, Wang R, Zhou X, Corvera J, Kloc M, Sifers R, Gallick GE, Lin SH, Kuang J. Extracellular Alix regulates integrin-mediated cell adhesions and extracellular matrix assembly. EMBO J. 2008 Aug 6; 27(15):2077-90. PMID: 18636094; PMCID: PMC2516883.
    20. Zhao Y, Haccard O, Wang R, Yu J, Kuang J, Jessus C, Goldberg ML. Roles of Greatwall kinase in the regulation of cdc25 phosphatase. Mol Biol Cell. 2008 Apr; 19(4):1317-27. PMID: 18199678; PMCID: PMC2291418.
    21. Feng Z, Wu CF, Zhou X, Kuang J. Alternative polyadenylation produces two major transcripts of Alix. Arch Biochem Biophys. 2007 Sep 15; 465(2):328-35. PMID: 17673164; PMCID: PMC4104816.
    22. Wu CF, Delsert C, Faure S, Traverso EE, Kloc M, Kuang J, Etkin LD, Morin N. Tumorhead distribution to cytoplasmic membrane of neural plate cells is positively regulated by Xenopus p21-activated kinase 1 (X-PAK1). Dev Biol. 2007 Aug 1; 308(1):169-86. PMID: 17560976.
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    23. Wang R, He G, Nelman-Gonzalez M, Ashorn CL, Gallick GE, Stukenberg PT, Kirschner MW, Kuang J. Regulation of Cdc25C by ERK-MAP kinases during the G2/M transition. Cell. 2007 Mar 23; 128(6):1119-32. PMID: 17382881.
      View in: PubMed
    24. Dejournett RE, Kobayashi R, Pan S, Wu C, Etkin LD, Clark RB, Bögler O, Kuang J. Phosphorylation of the proline-rich domain of Xp95 modulates Xp95 interaction with partner proteins. Biochem J. 2007 Jan 15; 401(2):521-31. PMID: 16978157; PMCID: PMC1820820.
    25. He G, Kuang J, Huang Z, Koomen J, Kobayashi R, Khokhar AR, Siddik ZH. Upregulation of p27 and its inhibition of CDK2/cyclin E activity following DNA damage by a novel platinum agent are dependent on the expression of p21. Br J Cancer. 2006 Dec 4; 95(11):1514-24. PMID: 17088910; PMCID: PMC2360737.
    26. Pan S, Wang R, Zhou X, He G, Koomen J, Kobayashi R, Sun L, Corvera J, Gallick GE, Kuang J. Involvement of the conserved adaptor protein Alix in actin cytoskeleton assembly. J Biol Chem. 2006 Nov 10; 281(45):34640-50. PMID: 16966331.
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    27. He G, Siddik ZH, Huang Z, Wang R, Koomen J, Kobayashi R, Khokhar AR, Kuang J. Induction of p21 by p53 following DNA damage inhibits both Cdk4 and Cdk2 activities. Oncogene. 2005 Apr 21; 24(18):2929-43. PMID: 15735718.
      View in: PubMed
    28. Lin SH, Nishino M, Luo W, Aumais JP, Galfione M, Kuang J, Yu-Lee LY. Inhibition of prostate tumor growth by overexpression of NudC, a microtubule motor-associated protein. Oncogene. 2004 Apr 1; 23(14):2499-506. PMID: 14676831.
      View in: PubMed
    29. Wu Y, Pan S, Luo W, Lin SH, Kuang J. Hp95 promotes anoikis and inhibits tumorigenicity of HeLa cells. Oncogene. 2002 Oct 3; 21(44):6801-8. PMID: 12360406.
      View in: PubMed
    30. Bolton MA, Lan W, Powers SE, McCleland ML, Kuang J, Stukenberg PT. Aurora B kinase exists in a complex with survivin and INCENP and its kinase activity is stimulated by survivin binding and phosphorylation. Mol Biol Cell. 2002 Sep; 13(9):3064-77. PMID: 12221116; PMCID: PMC124143.
    31. Kuang J, He G, Huang Z, Khokhar AR, Siddik ZH. Bimodal effects of 1R,2R-diaminocyclohexane(trans-diacetato)(dichloro)platinum(IV) on cell cycle checkpoints. Clin Cancer Res. 2001 Nov; 7(11):3629-39. PMID: 11705886.
      View in: PubMed
    32. Wu CF, Nakamura H, Chan AP, Zhou YH, Cao T, Kuang J, Gong SG, He G, Etkin LD. Tumorhead, a Xenopus gene product that inhibits neural differentiation through regulation of proliferation. Development. 2001 Sep; 128(17):3381-93. PMID: 11546754.
      View in: PubMed
    33. Wu Y, Pan S, Che S, He G, Nelman-Gonzalez M, Weil MM, Kuang J. Overexpression of Hp95 induces G1 phase arrest in confluent HeLa cells. Differentiation. 2001 Jun; 67(4-5):139-53. PMID: 11683497.
      View in: PubMed
    34. Nakamura H, Wu C, Kuang J, Larabell C, Etkin LD. XCS-1, a maternally expressed gene product involved in regulating mitosis in Xenopus. J Cell Sci. 2000 Jul; 113 ( Pt 13):2497-505. PMID: 10852828.
      View in: PubMed
    35. Che S, El-Hodiri HM, Wu CF, Nelman-Gonzalez M, Weil MM, Etkin LD, Clark RB, Kuang J. Identification and cloning of xp95, a putative signal transduction protein in Xenopus oocytes. J Biol Chem. 1999 Feb 26; 274(9):5522-31. PMID: 10026166.
      View in: PubMed
    36. Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet. 1998 Oct; 20(2):189-93. PMID: 9771714.
      View in: PubMed
    37. Barratt RA, Kao G, McKenna WG, Kuang J, Muschel RJ. The G2 block induced by DNA damage: a caffeine-resistant component independent of Cdc25C, MPM-2 phosphorylation, and H1 kinase activity. Cancer Res. 1998 Jun 15; 58(12):2639-45. PMID: 9635591.
      View in: PubMed
    38. Che S, Wu W, Nelman-Gonzalez M, Stukenberg T, Clark R, Kuang J. A phosphatase activity in Xenopus oocyte extracts preferentially dephosphorylates the MPM-2 epitope. FEBS Lett. 1998 Mar 13; 424(3):225-33. PMID: 9539156.
      View in: PubMed
    39. Yaffe MB, Schutkowski M, Shen M, Zhou XZ, Stukenberg PT, Rahfeld JU, Xu J, Kuang J, Kirschner MW, Fischer G, Cantley LC, Lu KP. Sequence-specific and phosphorylation-dependent proline isomerization: a potential mitotic regulatory mechanism. Science. 1997 Dec 12; 278(5345):1957-60. PMID: 9395400.
      View in: PubMed
    40. Che S, Weil MM, Etkin LD, Epstein HF, Kuang J. Molecular cloning of a splice variant of Caenorhabditis elegans YNK1, a putative element in signal transduction. Biochim Biophys Acta. 1997 Nov 20; 1354(3):231-40. PMID: 9427532.
      View in: PubMed
    41. Che S, Weil MM, Nelman-Gonzalez M, Ashorn CL, Kuang J. MPM-2 epitope sequence is not sufficient for recognition and phosphorylation by ME kinase-H. FEBS Lett. 1997 Aug 25; 413(3):417-23. PMID: 9303547.
      View in: PubMed
    42. El-Hodiri HM, Che S, Nelman-Gonzalez M, Kuang J, Etkin LD. Mitogen-activated protein kinase and cyclin B/Cdc2 phosphorylate Xenopus nuclear factor 7 (xnf7) in extracts from mature oocytes. Implications for regulation of xnf7 subcellular localization. J Biol Chem. 1997 Aug 15; 272(33):20463-70. PMID: 9252356.
      View in: PubMed
    43. Stukenberg PT, Lustig KD, McGarry TJ, King RW, Kuang J, Kirschner MW. Systematic identification of mitotic phosphoproteins. Curr Biol. 1997 May 1; 7(5):338-48. PMID: 9115395.
      View in: PubMed
    44. Shou W, Li X, Wu C, Cao T, Kuang J, Che S, Etkin LD. Finely tuned regulation of cytoplasmic retention of Xenopus nuclear factor 7 by phosphorylation of individual threonine residues. Mol Cell Biol. 1996 Mar; 16(3):990-7. PMID: 8622702; PMCID: PMC231081.
    45. Kuang J, Ashorn CL, Gonzalez-Kuyvenhoven M, Penkala JE. cdc25 is one of the MPM-2 antigens involved in the activation of maturation-promoting factor. Mol Biol Cell. 1994 Feb; 5(2):135-45. PMID: 8019000; PMCID: PMC301020.
    46. Kuang J, Ashorn CL. At least two kinases phosphorylate the MPM-2 epitope during Xenopus oocyte maturation. J Cell Biol. 1993 Nov; 123(4):859-68. PMID: 7693720; PMCID: PMC2200152.
    47. Kuang J, Penkala JE, Ashorn CL, Wright DA, Saunders GF, Rao PN. Multiple forms of maturation-promoting factor in unfertilized Xenopus eggs. Proc Natl Acad Sci U S A. 1991 Dec 15; 88(24):11530-4. PMID: 1662397; PMCID: PMC53169.
    48. Kuang J, Penkala JE, Wright DA, Saunders GF, Rao PN. A novel M phase-specific H1 kinase recognized by the mitosis-specific monoclonal antibody MPM-2. Dev Biol. 1991 Mar; 144(1):54-64. PMID: 1995402.
      View in: PubMed
    49. Kuang J, Zhao J, Wright DA, Saunders GF, Rao PN. Mitosis-specific monoclonal antibody MPM-2 inhibits Xenopus oocyte maturation and depletes maturation-promoting activity. Proc Natl Acad Sci U S A. 1989 Jul; 86(13):4982-6. PMID: 2662192.
      View in: PubMed
    50. Zhao JY, Kuang J, Adlakha RC, Rao PN. Threonine phosphorylation is associated with mitosis in HeLa cells. FEBS Lett. 1989 Jun 5; 249(2):389-95. PMID: 2500366.
      View in: PubMed
    51. Kuang J, Lian ML, Mi L, Wang KR. [Cyclic AMP, the cytoskeleton and control of cell replication. I. Relationship of cyclic AMP, microtubules and density-dependent growth]. Zhonghua Zhong Liu Za Zhi. 1987 Mar; 9(2):99-102. PMID: 2820685.
      View in: PubMed
    52. Erratum. Molecular Biology of the Cell. 5:611.
    53. Phosphorylation-Dependent Activation of the ESCRT Function of ALIX in Cytokinetic Abscission and Retroviral Budding. Developmental Cell. 36:331-343.
    54. Yes-mediated phosphorylation of focal adhesion kinase at tyrosine 861 increases metastatic potential of prostate cancer cells. Oncotarget. 6:10175-10194.
    55. RSK promotes prostate cancer progression in bone through ING3, CKAP2, and PTK6-mediated cell survival. Molecular Cancer Research. 13:348-357.
    56. Generation of cancer stem-like cells through the formation of polyploid giant cancer cells. Oncogene. 33:116-128.
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