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ANN M KILLARY

TitleProfessor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address2130 W Holcombe Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Haab BB, Huang Y, Balasenthil S, Partyka K, Tang H, Anderson M, Allen P, Sasson A, Zeh H, Kaul K, Kletter D, Ge S, Bern M, Kwon R, Blasutig I, Srivastava S, Frazier ML, Sen S, Hollingsworth MA, Rinaudo JA, Killary AM, Brand RE. Definitive Characterization of CA 19-9 in Resectable Pancreatic Cancer Using a Reference Set of Serum and Plasma Specimens. PLoS One. 2015; 10(10):e0139049. PMID: 26431551.
      View in: PubMed
    2. Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. Cancer Lett. 2015 Jan 28; 356(2 Pt B):404-9. PMID: 25304377.
      View in: PubMed
    3. Chen N, Balasenthil S, Reuther J, Killary AM. DEAR1, a novel tumor suppressor that regulates cell polarity and epithelial plasticity. Cancer Res. 2014 Oct 15; 74(20):5683-9. PMID: 25261235; PMCID: PMC4214267.
    4. Wang J, Raimondo M, Guha S, Chen J, Diao L, Dong X, Wallace MB, Killary AM, Frazier ML, Woodward TA, Wang J, Sen S. Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer. J Cancer. 2014; 5(8):696-705. PMID: 25258651.
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    5. Quintás-Cardama A, Post SM, Solis LM, Xiong S, Yang P, Chen N, Wistuba II, Killary AM, Lozano G. Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer. J Pathol. 2014 Sep; 234(1):108-19. PMID: 24890125.
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    6. Chen N, Balasenthil S, Reuther J, Frayna A, Wang Y, Chandler DS, Abruzzo LV, Rashid A, Rodriguez J, Lozano G, Cao Y, Lokken E, Chen J, Frazier ML, Sahin AA, Wistuba II, Sen S, Lott ST, Killary AM. DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-?-driven epithelial-mesenchymal transition. Cancer Discov. 2013 Oct; 3(10):1172-89. PMID: 23838884; PMCID: PMC4107927.
    7. Liu Q, Chen J, Wang J, Amos C, Killary AM, Sen S, Wei C, Frazier ML. Putative tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma. Mol Carcinog. 2014 Sep; 53(9):711-21. PMID: 23661430; PMCID: PMC3887131.
    8. Gambaro K, Quinn MC, Wojnarowicz PM, Arcand SL, de Ladurantaye M, Barrès V, Ripeau JS, Killary AM, Davis EC, Lavoie J, Provencher DM, Mes-Masson AM, Chevrette M, Tonin PN. VGLL3 expression is associated with a tumor suppressor phenotype in epithelial ovarian cancer. Mol Oncol. 2013 Jun; 7(3):513-30. PMID: 23415753.
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    9. Chen J, Wu X, Pande M, Amos CI, Killary AM, Sen S, Frazier ML. Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. Pancreas. 2011 Aug; 40(6):872-5. PMID: 21697764; PMCID: PMC3138891.
    10. Liu Q, Chen J, Mai B, Amos C, Killary AM, Sen S, Wei C, Frazier ML. A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians. Mol Carcinog. 2012 May; 51(5):433-8. PMID: 21656579; PMCID: PMC3780592.
    11. Balasenthil S, Chen N, Lott ST, Chen J, Carter J, Grizzle WE, Frazier ML, Sen S, Killary AM. A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. Cancer Prev Res (Phila). 2011 Jan; 4(1):137-49. PMID: 21071578.
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    12. Chen M, Gu J, Delclos GL, Killary AM, Fan Z, Hildebrandt MA, Chamberlain RM, Grossman HB, Dinney CP, Wu X. Genetic variations of the PI3K-AKT-mTOR pathway and clinical outcome in muscle invasive and metastatic bladder cancer patients. Carcinogenesis. 2010 Aug; 31(8):1387-91. PMID: 20530239; PMCID: PMC2915631.
    13. Chen J, Amos CI, Merriman KW, Wei Q, Sen S, Killary AM, Frazier ML. Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study. Pancreas. 2010 Jan; 39(1):1-4. PMID: 19910837.
      View in: PubMed
    14. Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S. MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev Res (Phila). 2009 Sep; 2(9):807-13. PMID: 19723895.
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    15. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med. 2009 May 26; 6(5):e1000068. PMID: 19536326; PMCID: PMC2673042.
    16. Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. Ann Surg Oncol. 2009 Feb; 16(2):431-9. PMID: 19020940.
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    17. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. Cancer Lett. 2008 Dec 8; 272(1):32-9. PMID: 18694622; PMCID: PMC3780599.
    18. Sasai K, Parant JM, Brandt ME, Carter J, Adams HP, Stass SA, Killary AM, Katayama H, Sen S. Targeted disruption of Aurora A causes abnormal mitotic spindle assembly, chromosome misalignment and embryonic lethality. Oncogene. 2008 Jul 3; 27(29):4122-7. PMID: 18345035.
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    19. Zhang K, Lott ST, Jin L, Killary AM. Fine mapping of the NRC-1 tumor suppressor locus within chromosome 3p12. Biochem Biophys Res Commun. 2007 Aug 31; 360(3):531-8. PMID: 17624313.
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    20. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. Clin Cancer Res. 2007 May 15; 13(10):3100-4. PMID: 17505013; PMCID: PMC2365501.
    21. Hu M, Nicolson GL, Trent JC, Yu D, Zhang L, Lang A, Killary A, Ellis LM, Bucana CD, Pollock RE. Characterization of 11 human sarcoma cell strains: evaluation of cytogenetics, tumorigenicity, metastasis, and production of angiogenic factors. Cancer. 2002 Oct 1; 95(7):1569-76. PMID: 12237927.
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    22. Lott ST, Chandler DS, Curley SA, Foster CJ, El-Naggar A, Frazier M, Strong LC, Lovell M, Killary AM. High frequency loss of heterozygosity in von Hippel-Lindau (VHL)-associated and sporadic pancreatic islet cell tumors: evidence for a stepwise mechanism for malignant conversion in VHL tumorigenesis. Cancer Res. 2002 Apr 1; 62(7):1952-5. PMID: 11929809.
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    23. Padalecki SS, Johnson-Pais TL, Killary AM, Leach RJ. Chromosome 18 suppresses the tumorigenicity of prostate cancer cells. Genes Chromosomes Cancer. 2001 Mar; 30(3):221-9. PMID: 11170278.
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    24. Kruzelock RP, Cuevas BD, Wiener JR, Xu FJ, Yu Y, Cabeza-Arvelaiz Y, Pershouse M, Lovell MM, Killary AM, Mills GB, Bast RC. Functional evidence for an ovarian cancer tumor suppressor gene on chromosome 22 by microcell-mediated chromosome transfer. Oncogene. 2000 Dec 14; 19(54):6277-85. PMID: 11175342.
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    25. el-Naggar AK, Lovell M, Callender DL, Ordonez NG, Killary AM. Cytogenetic analysis of a primary salivary gland myoepithelioma. Cancer Genet Cytogenet. 1999 Aug; 113(1):49-53. PMID: 10459346.
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    26. Lovell M, Lott ST, Wong P, El-Naggar A, Tucker S, Killary AM. The genetic locus NRC-1 within chromosome 3p12 mediates tumor suppression in renal cell carcinoma independently of histological type, tumor microenvironment, and VHL mutation. Cancer Res. 1999 May 1; 59(9):2182-9. PMID: 10232606.
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    27. el-Naggar AK, Lovell M, Callender DL, Killary AM. Limited nonrandom chromosomal aberrations in a recurrent adenoid cystic carcinoma of the parotid gland. Cancer Genet Cytogenet. 1999 Feb; 109(1):66-9. PMID: 9973962.
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    28. el-Naggar AK, Lovell M, Callender DL, Ordonez NG, Killary AM. Concurrent cytogenetic, interphase fluorescence in situ hybridization and DNA flow cytometric analyses of a carcinoma ex-pleomorphic adenoma of parotid gland. Cancer Genet Cytogenet. 1998 Dec; 107(2):132-6. PMID: 9844608.
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    29. Lott ST, Lovell M, Naylor SL, Killary AM. Physical and functional mapping of a tumor suppressor locus for renal cell carcinoma within chromosome 3p12. Cancer Res. 1998 Aug 15; 58(16):3533-7. PMID: 9721855.
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    30. Curley SA, Lott ST, Luca JW, Frazier ML, Killary AM. Surgical decision-making affected by clinical and genetic screening of a novel kindred with von Hippel-Lindau disease and pancreatic islet cell tumors. Ann Surg. 1998 Feb; 227(2):229-35. PMID: 9488521; PMCID: PMC1191240.
    31. el-Naggar AK, Lovell M, Ordonez NG, Killary AM. Multiple unrelated translocations in a metastatic epimyoepithelial carcinoma of the parotid gland. Cancer Genet Cytogenet. 1998 Jan 15; 100(2):155-8. PMID: 9428361.
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    32. Pershouse MA, Ligon AH, Pereira-Smith OM, Killary AM, Yung WK, Steck PA. Suppression of transformed phenotype and tumorigenicity after transfer of chromosome 4 into U251 human glioma cells. Genes Chromosomes Cancer. 1997 Nov; 20(3):260-7. PMID: 9365833.
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    33. Todd MC, Xiang RH, Garcia DK, Kerbacher KE, Moore SL, Hensel CH, Liu P, Siciliano MJ, Kok K, van den Berg A, Veldhuis P, Buys CH, Killary AM, Naylor SL. An 80 Kb P1 clone from chromosome 3p21.3 suppresses tumor growth in vivo. Oncogene. 1996 Dec 5; 13(11):2387-96. PMID: 8957080.
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    34. el-Naggar AK, Lovell M, Killary AM, Batsakis JG. Genotypic characterization of a primary mucoepidermoid carcinoma of the parotid gland by cytogenetic, fluorescence in situ hybridization, and DNA ploidy analysis. Cancer Genet Cytogenet. 1996 Jul 1; 89(1):38-43. PMID: 8689608.
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    35. Sanchez Y, Lovell M, Marin MC, Wong PE, Wolf-Ledbetter ME, McDonnell TJ, Killary AM. Tumor suppression and apoptosis of human prostate carcinoma mediated by a genetic locus within human chromosome 10pter-q11. Proc Natl Acad Sci U S A. 1996 Mar 19; 93(6):2551-6. PMID: 8637912; PMCID: PMC39835.
    36. El-Naggar AK, Lovell M, Killary AM, Clayman GL, Batsakis JG. A mucoepidermoid carcinoma of minor salivary gland with t(11;19)(q21;p13.1) as the only karyotypic abnormality. Cancer Genet Cytogenet. 1996 Mar; 87(1):29-33. PMID: 8646736.
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    37. Ichikawa T, Nihei N, Kuramochi H, Kawana Y, Killary AM. Metastasis suppressor genes for prostate cancer. Prostate Suppl. 1996; 6:31-5. PMID: 8630227.
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    38. Naylor SL, Carritt B, Boileau C, Beroud C, Alexander C, Allderdice P, Alimov A, Ashworth T, Bonifas J, Bugert P, Buys CH, Chipperfield MA, Deng G, Drabkin H, Gemmill RM, Grompe M, Joensuu T, Jonasdottir A, Gizatullin R, Krols L, Leach RJ, Lott ST, Killary A, Martinsson T, Messiaen L, et al. Report of the sixth international workshop on human chromosome 3 mapping 1995. Cytogenet Cell Genet. 1996; 72(4):255-70. PMID: 8641130.
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    39. Nihei N, Ichikawa T, Kawana Y, Kuramochi H, Kugo H, Oshimura M, Killary AM, Rinker-Schaeffer CW, Barrett JC, Isaacs JT, et al. Localization of metastasis suppressor gene(s) for rat prostatic cancer to the long arm of human chromosome 10. Genes Chromosomes Cancer. 1995 Oct; 14(2):112-9. PMID: 8527392.
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    40. Yulug IG, Killary AM, Sandhu AK, Athwal RS, Fox M, Fisher EM. Gene expression in response to retinoic acid in novel human chromosome 21 monochromosomal cell hybrids. Somat Cell Mol Genet. 1995 Sep; 21(5):357-65. PMID: 8619133.
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    41. Woloshin P, Song K, Degnin C, Killary AM, Goldhamer DJ, Sassoon D, Thayer MJ. MSX1 inhibits myoD expression in fibroblast x 10T1/2 cell hybrids. Cell. 1995 Aug 25; 82(4):611-20. PMID: 7664340.
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    42. Killary AM, Fournier RE. Microcell fusion. Methods Enzymol. 1995; 254:133-52. PMID: 8531682.
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    43. el-Naggar AK, Lovell M, Killary A, Batsakis JG. Trisomy 5 as the sole chromosomal abnormality in a primary mucoepidermoid carcinoma of the minor salivary gland. Cancer Genet Cytogenet. 1994 Sep; 76(2):96-9. PMID: 7923075.
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    44. Sanchez Y, el-Naggar A, Pathak S, Killary AM. A tumor suppressor locus within 3p14-p12 mediates rapid cell death of renal cell carcinoma in vivo. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3383-7. PMID: 8159756; PMCID: PMC43581.
    45. Pershouse MA, Stubblefield E, Hadi A, Killary AM, Yung WK, Steck PA. Analysis of the functional role of chromosome 10 loss in human glioblastomas. Cancer Res. 1993 Oct 15; 53(20):5043-50. PMID: 8104691.
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    46. Daly MC, Xiang RH, Buchhagen D, Hensel CH, Garcia DK, Killary AM, Minna JD, Naylor SL. A homozygous deletion on chromosome 3 in a small cell lung cancer cell line correlates with a region of tumor suppressor activity. Oncogene. 1993 Jul; 8(7):1721-9. PMID: 8390035.
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    47. Killary AM, Wolf ME, Giambernardi TA, Naylor SL. Definition of a tumor suppressor locus within human chromosome 3p21-p22. Proc Natl Acad Sci U S A. 1992 Nov 15; 89(22):10877-81. PMID: 1438292; PMCID: PMC50445.
    48. Sleister HM, Mills KA, Blackwell SE, Killary AM, Murray JC, Malone RE. Construction of a human chromosome 4 YAC pool and analysis of artificial chromosome stability. Nucleic Acids Res. 1992 Jul 11; 20(13):3419-25. PMID: 1630913.
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    49. Glisson BS, Killary AM, Merta P, Ross WE, Siciliano J, Siciliano MJ. Dissociation of cytotoxicity and DNA cleavage activity induced by topoisomerase II-reactive intercalating agents in hamster-human somatic cell hybrids. Cancer Chemother Pharmacol. 1992; 31(2):131-8. PMID: 1333369.
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    50. Ning Y, Weber JL, Killary AM, Ledbetter DH, Smith JR, Pereira-Smith OM. Genetic analysis of indefinite division in human cells: evidence for a cell senescence-related gene(s) on human chromosome 4. Proc Natl Acad Sci U S A. 1991 Jul 1; 88(13):5635-9. PMID: 2062841; PMCID: PMC51932.
    51. Tait JF, Frankenberry DA, Miao CH, Killary AM, Adler DA, Disteche CM. Chromosomal localization of the human annexin III (ANX3) gene. Genomics. 1991 Jun; 10(2):441-8. PMID: 1830024.
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    52. Weber JL, Kwitek AE, May PE, Killary AM. Dinucleotide repeat polymorphism at the D4S174 locus. Nucleic Acids Res. 1990 Aug 11; 18(15):4636. PMID: 2388858; PMCID: PMC331327.
    53. Weber JL, May PE, Patterson D, Drabkin H, Killary AM. Dinucleotide repeat polymorphism at the D3S196 locus. Nucleic Acids Res. 1990 Aug 11; 18(15):4635. PMID: 2388857.
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    54. Sakaguchi AY, Lalley PA, Choudhury GG, Martinez L, Han ES, Killary AM, Naylor SL, Wang LM. Mouse melanoma growth stimulatory activity gene (Mgsa) is polymorphic and syntenic with the W, patch, rumpwhite, and recessive spotting loci on chromosome 5. Genomics. 1989 Oct; 5(3):629-32. PMID: 2575589.
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    55. Hsieh CL, Lee WH, Lee EY, Killary AM, Lalley PA, Naylor SL. Assignment of retinoblastoma susceptibility gene to mouse chromosome 14. Somat Cell Mol Genet. 1989 Sep; 15(5):461-4. PMID: 2781416.
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    56. Smith A, Lalley PA, Killary AM, Ghosh-Choudhury G, Wang LM, Han ES, Martinez L, Naylor SL, Sakaguchi AY. Sigje, a member of the small inducible gene family that includes platelet factor 4 and melanoma growth stimulatory activity, is on mouse chromosome 11. Cytogenet Cell Genet. 1989; 52(3-4):194-6. PMID: 2576529.
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    57. Wang LM, Killary AM, Fang XE, Parriott SK, Lalley PA, Bell GI, Sakaguchi AY. Chromosome assignment of mouse insulin, colony stimulating factor 1, and low-density lipoprotein receptors. Genomics. 1988 Aug; 3(2):172-6. PMID: 3066742.
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    58. Rajput B, Marshall A, Killary AM, Lalley PA, Naylor SL, Belin D, Rickles RJ, Strickland S. Chromosomal assignments of genes for tissue plasminogen activator and urokinase in mouse. Somat Cell Mol Genet. 1987 Sep; 13(5):581-6. PMID: 2821634.
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    59. Lugo TG, Handelin B, Killary AM, Housman DE, Fournier RE. Isolation of microcell hybrid clones containing retroviral vector insertions into specific human chromosomes. Mol Cell Biol. 1987 Aug; 7(8):2814-20. PMID: 2823107.
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    60. Meinkoth J, Killary AM, Fournier RE, Wahl GM. Unstable and stable CAD gene amplification: importance of flanking sequences and nuclear environment in gene amplification. Mol Cell Biol. 1987 Apr; 7(4):1415-24. PMID: 3600632.
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    61. Killary AM, Leach RJ, Moran RG, Fournier RE. Assignment of genes encoding dihydrofolate reductase and hexosaminidase B to Mus musculus chromosome 13. Somat Cell Mol Genet. 1986 Nov; 12(6):641-8. PMID: 2947337.
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    62. Peterson TC, Killary AM, Fournier RE. Chromosomal assignment and trans regulation of the tyrosine aminotransferase structural gene in hepatoma hybrid cells. Mol Cell Biol. 1985 Sep; 5(9):2491-4. PMID: 2874483; PMCID: PMC366977.
    63. Killary AM, Fournier RE. An isozyme-specific selective system for the recovery of mammalian cells deficient in hepatic alcohol dehydrogenase activity. Exp Cell Res. 1984 Oct; 154(2):442-53. PMID: 6383854.
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    64. Killary AM, Fournier RE. A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell. 1984 Sep; 38(2):523-34. PMID: 6147198.
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    65. Killary AM, Lugo TG, Fournier RE. Isolation of thymidine kinase-deficient rat hepatoma cells by selection with bromodeoxyuridine, Hoechst 33258, and visible light. Biochem Genet. 1984 Apr; 22(3-4):201-13. PMID: 6203516.
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    66. McNeill CA, Brown RL. Genetic manipulation by means of microcell-mediated transfer of normal human chromosomes into recipient mouse cells. Proc Natl Acad Sci U S A. 1980 Sep; 77(9):5394-8. PMID: 7001478.
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    67. Identification of genetic variants predictive of early onset pancreatic cancer through a population science analysis of functional genomic datasets. Oncotarget. 7:56480-56490.
    68. Report of the sixth international workshop on human chromosome 3 mapping 1995. Cytogenetics and Cell Genetics. 72:255270.
    69. Circulating microRNAs in pancreatic juice as candidate biomarkers of pancreatic cancer. Journal of Cancer. 5:696-705.
    70. Production of microcell hybrids. Methods: A Companion to Methods in Enzymology. 9:3-11.
    71. Functional Studies to Identify Tumor Suppressor Genes. Methods. 8:234-246.
    72. Metastasis suppressor genes for prostate cancer. Prostate. 28:31-35.
    73. Definitive characterization of CA 19-9 in resectable pancreatic cancer using a reference set of serum and plasma specimens. PLoS One. 10.
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