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TitleAssociate Professor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Collapse Research 
    Collapse research activities and funding
    R01CA136549     (LU, XIONGBIN)May 1, 2009 - Feb 28, 2014
    Regulation of the ATM/ATR-p53 DNA Damage Signaling Pathway by the Wip1 Phosphatas
    Role: Principal Investigator

    R03CA142605     (LU, XIONGBIN)Sep 30, 2009 - Aug 31, 2011
    Identification of Novel Protein Phosphatases in the ATM Signaling Pathway
    Role: Principal Investigator

    R21CA185742     (LU, XIONGBIN)Mar 1, 2015 - Feb 28, 2018
    Ubiquitin specific peptidases as redox sensor in oncogene-induced p53 signaling
    Role: Principal Investigator

    R01CA203737     (LU, XIONGBIN)Apr 1, 2016 - Mar 31, 2021
    Targeting Human Cancers with Hemizygous Deletion of TP53
    Role: Principal Investigator

    R01CA206366     (HE, XIAOMING)Jul 8, 2016 - Jun 30, 2021
    Nanotechnology enabled targeting of p53 deficiency in human cancer
    Role: Co-Principal Investigator

    R21CA213535     (WANG, JIN)Jun 13, 2017 - May 31, 2019
    Engineering Antibody Drug Conjugates To Target P53-Defective Triple Negative Breast Cancer
    Role: Co-Principal Investigator

    R01CA222251     (LU, XIONGBIN)Feb 2, 2018 - Jan 31, 2023
    Identification of USP13 as a therapeutic target for ovarian cancer
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Zhang B, Wang E, Dai H, Shen J, Hsieh HJ, Lu X, Peng G. Phosphorylation of the BRCA1 C terminus (BRCT) repeat inhibitor of hTERT (BRIT1) protein coordinates TopBP1 protein recruitment and amplifies ataxia telangiectasia-mutated and Rad3-related (ATR) Signaling. J Biol Chem. 2014 Dec 05; 289(49):34284-95. PMID: 25301947; PMCID: PMC4256359.
    2. Han C, Liu Y, Wan G, Choi HJ, Zhao L, Ivan C, He X, Sood AK, Zhang X, Lu X. The RNA-binding protein DDX1 promotes primary microRNA maturation and inhibits ovarian tumor progression. Cell Rep. 2014 Sep 11; 8(5):1447-60. PMID: 25176654; PMCID: PMC4163106.
    3. Rao W, Zhang W, Poventud-Fuentes I, Wang Y, Lei Y, Agarwal P, Weekes B, Li C, Lu X, Yu J, He X. Thermally responsive nanoparticle-encapsulated curcumin and its combination with mild hyperthermia for enhanced cancer cell destruction. Acta Biomater. 2014 Feb; 10(2):831-42. PMID: 24516867; PMCID: PMC4136765.
    4. Zhou Y, Wan G, Spizzo R, Ivan C, Mathur R, Hu X, Ye X, Lu J, Fan F, Xia L, Calin GA, Ellis LM, Lu X. miR-203 induces oxaliplatin resistance in colorectal cancer cells by negatively regulating ATM kinase. Mol Oncol. 2014 Feb; 8(1):83-92. PMID: 24145123; PMCID: PMC4124530.
    5. Wan G, Hu X, Liu Y, Han C, Sood AK, Calin GA, Zhang X, Lu X. A novel non-coding RNA lncRNA-JADE connects DNA damage signalling to histone H4 acetylation. EMBO J. 2013 Oct 30; 32(21):2833-47. PMID: 24097061; PMCID: PMC3817469.
    6. Wan G, Liu Y, Han C, Zhang X, Lu X. Noncoding RNAs in DNA repair and genome integrity. Antioxid Redox Signal. 2014 Feb 01; 20(4):655-77. PMID: 23879367; PMCID: PMC3901350.
    7. Wan G, Zhang X, Langley RR, Liu Y, Hu X, Han C, Peng G, Ellis LM, Jones SN, Lu X. DNA-damage-induced nuclear export of precursor microRNAs is regulated by the ATM-AKT pathway. Cell Rep. 2013 Jun 27; 3(6):2100-12. PMID: 23791529; PMCID: PMC3796289.
    8. Zhao L, Lu X, Cao Y. MicroRNA and signal transduction pathways in tumor radiation response. Cell Signal. 2013 Jul; 25(7):1625-34. PMID: 23602933; PMCID: PMC3713775.
    9. Wan G, Mathur R, Hu X, Liu Y, Zhang X, Peng G, Lu X. Long non-coding RNA ANRIL (CDKN2B-AS) is induced by the ATM-E2F1 signaling pathway. Cell Signal. 2013 May; 25(5):1086-95. PMID: 23416462.
      View in: PubMed
    10. Lu Z, Wan G, Guo H, Zhang X, Lu X. Protein phosphatase 1 inhibits p53 signaling by dephosphorylating and stabilizing Mdmx. Cell Signal. 2013 Apr; 25(4):796-804. PMID: 23277204.
      View in: PubMed
    11. Zane L, Yasunaga J, Mitagami Y, Yedavalli V, Tang SW, Chen CY, Ratner L, Lu X, Jeang KT. Wip1 and p53 contribute to HTLV-1 Tax-induced tumorigenesis. Retrovirology. 2012 Dec 21; 9:114. PMID: 23256545; PMCID: PMC3532233.
    12. Han C, Wan G, Langley RR, Zhang X, Lu X. Crosstalk between the DNA damage response pathway and microRNAs. Cell Mol Life Sci. 2012 Sep; 69(17):2895-906. PMID: 22430204.
      View in: PubMed
    13. Zhang X, Lu X. Posttranscriptional regulation of miRNAs in the DNA damage response. RNA Biol. 2011 Nov-Dec; 8(6):960-3. PMID: 21941125; PMCID: PMC3256419.
    14. Darlington Y, Nguyen TA, Moon SH, Herron A, Rao P, Zhu C, Lu X, Donehower LA. Absence of Wip1 partially rescues Atm deficiency phenotypes in mice. Oncogene. 2012 Mar 01; 31(9):1155-65. PMID: 21765465; PMCID: PMC3197977.
    15. Wan G, Mathur R, Hu X, Zhang X, Lu X. miRNA response to DNA damage. Trends Biochem Sci. 2011 Sep; 36(9):478-84. PMID: 21741842; PMCID: PMC3532742.
    16. Yasunaga J, Lin FC, Lu X, Jeang KT. Ubiquitin-specific peptidase 20 targets TRAF6 and human T cell leukemia virus type 1 tax to negatively regulate NF-kappaB signaling. J Virol. 2011 Jul; 85(13):6212-9. PMID: 21525354; PMCID: PMC3126525.
    17. Zhang X, Berger FG, Yang J, Lu X. USP4 inhibits p53 through deubiquitinating and stabilizing ARF-BP1. EMBO J. 2011 Jun 01; 30(11):2177-89. PMID: 21522127; PMCID: PMC3117646.
    18. Fan YH, Yu Y, Mao RF, Tan XJ, Xu GF, Zhang H, Lu XB, Fu SB, Yang J. USP4 targets TAK1 to downregulate TNFa-induced NF-?B activation. Cell Death Differ. 2011 Oct; 18(10):1547-60. PMID: 21331078; PMCID: PMC3136563.
    19. Zhang X, Wan G, Berger FG, He X, Lu X. The ATM kinase induces microRNA biogenesis in the DNA damage response. Mol Cell. 2011 Feb 18; 41(4):371-83. PMID: 21329876; PMCID: PMC3114434.
    20. Zhang W, Gilstrap K, Wu L, K C RB, Moss MA, Wang Q, Lu X, He X. Synthesis and characterization of thermally responsive Pluronic F127-chitosan nanocapsules for controlled release and intracellular delivery of small molecules. ACS Nano. 2010 Nov 23; 4(11):6747-59. PMID: 21038924.
      View in: PubMed
    21. Zhang X, Wan G, Mlotshwa S, Vance V, Berger FG, Chen H, Lu X. Oncogenic Wip1 phosphatase is inhibited by miR-16 in the DNA damage signaling pathway. Cancer Res. 2010 Sep 15; 70(18):7176-86. PMID: 20668064; PMCID: PMC2940956.
    22. Shang X, Vasudevan SA, Yu Y, Ge N, Ludwig AD, Wesson CL, Wang K, Burlingame SM, Zhao YJ, Rao PH, Lu X, Russell HV, Okcu MF, Hicks MJ, Shohet JM, Donehower LA, Nuchtern JG, Yang J. Dual-specificity phosphatase 26 is a novel p53 phosphatase and inhibits p53 tumor suppressor functions in human neuroblastoma. Oncogene. 2010 Sep 02; 29(35):4938-46. PMID: 20562916.
      View in: PubMed
    23. Moon SH, Nguyen TA, Darlington Y, Lu X, Donehower LA. Dephosphorylation of ?-H2AX by WIP1: an important homeostatic regulatory event in DNA repair and cell cycle control. Cell Cycle. 2010 Jun 01; 9(11):2092-6. PMID: 20495376; PMCID: PMC3984036.
    24. Nguyen TA, Slattery SD, Moon SH, Darlington YF, Lu X, Donehower LA. The oncogenic phosphatase WIP1 negatively regulates nucleotide excision repair. DNA Repair (Amst). 2010 Jul 01; 9(7):813-23. PMID: 20451471; PMCID: PMC2893264.
    25. Sun W, Wang H, Zhao X, Yu Y, Fan Y, Wang H, Wang X, Lu X, Zhang G, Fu S, Yang J. Protein phosphatase 2A acts as a mitogen-activated protein kinase kinase kinase 3 (MEKK3) phosphatase to inhibit lysophosphatidic acid-induced IkappaB kinase beta/nuclear factor-kappaB activation. J Biol Chem. 2010 Jul 09; 285(28):21341-8. PMID: 20448038; PMCID: PMC2898379.
    26. Sun W, Tan X, Shi Y, Xu G, Mao R, Gu X, Fan Y, Yu Y, Burlingame S, Zhang H, Rednam SP, Lu X, Zhang T, Fu S, Cao G, Qin J, Yang J. USP11 negatively regulates TNFalpha-induced NF-kappaB activation by targeting on IkappaBalpha. Cell Signal. 2010 Mar; 22(3):386-94. PMID: 19874889; PMCID: PMC2794974.
    27. Moon SH, Lin L, Zhang X, Nguyen TA, Darlington Y, Waldman AS, Lu X, Donehower LA. Wild-type p53-induced phosphatase 1 dephosphorylates histone variant gamma-H2AX and suppresses DNA double strand break repair. J Biol Chem. 2010 Apr 23; 285(17):12935-47. PMID: 20118229; PMCID: PMC2857113.
    28. Zhang X, Lin L, Guo H, Yang J, Jones SN, Jochemsen A, Lu X. Phosphorylation and degradation of MdmX is inhibited by Wip1 phosphatase in the DNA damage response. Cancer Res. 2009 Oct 15; 69(20):7960-8. PMID: 19808970; PMCID: PMC2763051.
    29. Feng X, Lu X, Man X, Zhou W, Jiang LQ, Knyazev P, Lei L, Huang Q, Ullrich A, Zhang Z, Chen Z. Overexpression of Csk-binding protein contributes to renal cell carcinogenesis. Oncogene. 2009 Sep 17; 28(37):3320-31. PMID: 19581936.
      View in: PubMed
    30. Sun W, Yu Y, Dotti G, Shen T, Tan X, Savoldo B, Pass AK, Chu M, Zhang D, Lu X, Fu S, Lin X, Yang J. PPM1A and PPM1B act as IKKbeta phosphatases to terminate TNFalpha-induced IKKbeta-NF-kappaB activation. Cell Signal. 2009 Jan; 21(1):95-102. PMID: 18930133; PMCID: PMC2658596.
    31. Lu X, Nguyen TA, Moon SH, Darlington Y, Sommer M, Donehower LA. The type 2C phosphatase Wip1: an oncogenic regulator of tumor suppressor and DNA damage response pathways. Cancer Metastasis Rev. 2008 Jun; 27(2):123-35. PMID: 18265945; PMCID: PMC2362138.
    32. Lu X, Nguyen TA, Zhang X, Donehower LA. The Wip1 phosphatase and Mdm2: cracking the "Wip" on p53 stability. Cell Cycle. 2008 Jan 15; 7(2):164-8. PMID: 18333294.
      View in: PubMed
    33. Moore L, Lu X, Ghebranious N, Tyner S, Donehower LA. Aging-associated truncated form of p53 interacts with wild-type p53 and alters p53 stability, localization, and activity. Mech Ageing Dev. 2007 Nov-Dec; 128(11-12):717-30. PMID: 18061646; PMCID: PMC2680148.
    34. Castellino RC, De Bortoli M, Lu X, Moon SH, Nguyen TA, Shepard MA, Rao PH, Donehower LA, Kim JY. Medulloblastomas overexpress the p53-inactivating oncogene WIP1/PPM1D. J Neurooncol. 2008 Feb; 86(3):245-56. PMID: 17932621; PMCID: PMC2174521.
    35. Lu X, Ma O, Nguyen TA, Jones SN, Oren M, Donehower LA. The Wip1 Phosphatase acts as a gatekeeper in the p53-Mdm2 autoregulatory loop. Cancer Cell. 2007 Oct; 12(4):342-54. PMID: 17936559.
      View in: PubMed
    36. Nannenga B, Lu X, Dumble M, Van Maanen M, Nguyen TA, Sutton R, Kumar TR, Donehower LA. Augmented cancer resistance and DNA damage response phenotypes in PPM1D null mice. Mol Carcinog. 2006 Aug; 45(8):594-604. PMID: 16652371.
      View in: PubMed
    37. Adams MM, Wang B, Xia Z, Morales JC, Lu X, Donehower LA, Bochar DA, Elledge SJ, Carpenter PB. 53BP1 oligomerization is independent of its methylation by PRMT1. Cell Cycle. 2005 Dec; 4(12):1854-61. PMID: 16294047.
      View in: PubMed
    38. Lu X, Nguyen TA, Donehower LA. Reversal of the ATM/ATR-mediated DNA damage response by the oncogenic phosphatase PPM1D. Cell Cycle. 2005 Aug; 4(8):1060-4. PMID: 15970689.
      View in: PubMed
    39. Lu X, Nannenga B, Donehower LA. PPM1D dephosphorylates Chk1 and p53 and abrogates cell cycle checkpoints. Genes Dev. 2005 May 15; 19(10):1162-74. PMID: 15870257; PMCID: PMC1132003.
    40. Lu X, Nguyen TA, Appella E, Donehower LA. Homeostatic regulation of base excision repair by a p53-induced phosphatase: linking stress response pathways with DNA repair proteins. Cell Cycle. 2004 Nov; 3(11):1363-6. PMID: 15539943.
      View in: PubMed
    41. Lu X, Bocangel D, Nannenga B, Yamaguchi H, Appella E, Donehower LA. The p53-induced oncogenic phosphatase PPM1D interacts with uracil DNA glycosylase and suppresses base excision repair. Mol Cell. 2004 Aug 27; 15(4):621-34. PMID: 15327777.
      View in: PubMed
    42. Lu X, Lozano G, Donehower LA. Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutat Res. 2003 Jan 28; 522(1-2):69-83. PMID: 12517413.
      View in: PubMed
    43. Dumble ML, Donehower LA, Lu X. Generation and characterization of p53 mutant mice. Methods Mol Biol. 2003; 234:29-49. PMID: 12824523.
      View in: PubMed
    44. Lu X, Xiong Y, Silver J. Asymmetric requirement for cholesterol in receptor-bearing but not envelope-bearing membranes for fusion mediated by ecotropic murine leukemia virus. J Virol. 2002 Jul; 76(13):6701-9. PMID: 12050383; PMCID: PMC136268.
    45. Tyner SD, Venkatachalam S, Choi J, Jones S, Ghebranious N, Igelmann H, Lu X, Soron G, Cooper B, Brayton C, Park SH, Thompson T, Karsenty G, Bradley A, Donehower LA. p53 mutant mice that display early ageing-associated phenotypes. Nature. 2002 Jan 03; 415(6867):45-53. PMID: 11780111.
      View in: PubMed
    46. Lu X, Silver J. Transmission of replication-defective Sindbis helper vectors encoding capsid and envelope proteins. J Virol Methods. 2001 Jan; 91(1):59-65. PMID: 11164486.
      View in: PubMed
    47. Lu X, Silver J. Ecotropic murine leukemia virus receptor is physically associated with caveolin and membrane rafts. Virology. 2000 Oct 25; 276(2):251-8. PMID: 11040117.
      View in: PubMed
    48. Zhang X, Lu X, Jing N, Zhu S. cDNA cloning and functional expression of growth hormone receptor from soft-shelled turtle (Pelodiscus sinensis japonicus). Gen Comp Endocrinol. 2000 Sep; 119(3):265-75. PMID: 11017774.
      View in: PubMed
    49. Targeting Stromal Glutamine Synthetase in Tumors Disrupts Tumor Microenvironment-Regulated Cancer Cell Growth. Cell Metabolism. 24:685-700.
    50. The big player governs small world too. Cell Cycle. 13:2655.
    51. A new way to target p53-defective colorectal cancer. Future Oncology. 11:3101-3104.
    52. Continuous on-chip cell separation based on conductivity-induced dielectrophoresis with 3D self-assembled ionic liquid electrodes. Analytical Chemistry. 88:8264-8271.
    53. TP53 loss creates therapeutic vulnerability in colorectal cancer. Nature. 520:697-701.
    54. Localization of PS9 in rice ragged stunt oryzavirus and its role in virus transmission by brown planthopper. Acta Biochimica et Biophysica Sinica. 31:183-184.
    55. Erratum. Advanced Materials. 28:1723.
    56. CDNA cloning of the guinea pig growth hormone receptor. Acta Biochimica et Biophysica Sinica. 32:83.
    57. Amplification of USP13 drives ovarian cancer metabolism. Nature Communications. 7.
    58. VEGFR-1 pseudogene expression and regulatory function in human colorectal cancer cells. Molecular Cancer Research. 13:1274-1282.
    59. Rice Ragged Stunt Oryzavirus. Annals of Applied Biology. 135:573-578.
    60. Controlled release and intracellular delivery of small molecules using thermally responsive pluronic F127-chitosan nanocapsules. 445-446.
    61. Improved primary cell culture and subculture of lymphoid organs of the greasyback shrimp Metapenaeus ensis. Aquaculture. 410-411:101-113.
    62. A biomimetic hybrid nanoplatform for encapsulation and precisely controlled delivery of therasnostic agents. Nature Communications. 6.
    63. Erratum. Nature Communications. 7.
    64. Targeting tumor suppressor genes for cancer therapy. BioEssays. 37:1277-1286.
    65. Nanodrug-mediated thermotherapy of cancer stem-like cells. Journal of Nanoscience and Nanotechnology. 16:2134-2142.
    66. Enhanced microwave hyperthermia of cancer cells with fullerene. Molecular Pharmaceutics. 13:2184-2192.
    67. Combined cancer therapy with hyaluronan-decorated fullerene-silica multifunctional nanoparticles to target cancer stem-like cells. Biomaterials. 97:62-73.
    68. Posttranscriptional regulation of miRNAs in the DNA damage response. RNA Biology. 8.
    69. A Near-Infrared Laser-Activated "nanobomb" for Breaking the Barriers to MicroRNA Delivery. Advanced Materials. 28:347-355.
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