TitleAssociate Professor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Kim JH, Sharma A, Dhar SS, Lee SH, Gu B, Chan CH, Lin HK, Lee MG. UTX and MLL4 coordinately regulate transcriptional programs for cell proliferation and invasiveness in breast cancer cells. Cancer Res. 2014 Mar 15; 74(6):1705-17. PMID: 24491801; PMCID: PMC3962500.
      Citations: 105     Fields:    Translation:HumansAnimalsCells
    2. Dhar SS, Alam H, Li N, Wagner KW, Chung J, Ahn YW, Lee MG. Transcriptional repression of histone deacetylase 3 by the histone demethylase KDM2A is coupled to tumorigenicity of lung cancer cells. J Biol Chem. 2014 Mar 14; 289(11):7483-96. PMID: 24482232; PMCID: PMC3953262.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    3. Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach JV, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013 Dec; 123(12):5231-46. PMID: 24200691; PMCID: PMC3859406.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    4. Dhar SS, Lee SH, Kan PY, Voigt P, Ma L, Shi X, Reinberg D, Lee MG. Trans-tail regulation of MLL4-catalyzed H3K4 methylation by H4R3 symmetric dimethylation is mediated by a tandem PHD of MLL4. Genes Dev. 2012 Dec 15; 26(24):2749-62. PMID: 23249737; PMCID: PMC3533079.
      Citations: 91     Fields:    Translation:HumansCells
    5. Wen H, Li J, Song T, Lu M, Kan PY, Lee MG, Sha B, Shi X. Recognition of histone H3K4 trimethylation by the plant homeodomain of PHF2 modulates histone demethylation. J Biol Chem. 2010 Mar 26; 285(13):9322-9326. PMID: 20129925; PMCID: PMC2843180.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    6. Smith ER, Lee MG, Winter B, Droz NM, Eissenberg JC, Shiekhattar R, Shilatifard A. Drosophila UTX is a histone H3 Lys27 demethylase that colocalizes with the elongating form of RNA polymerase II. Mol Cell Biol. 2008 Feb; 28(3):1041-6. PMID: 18039863; PMCID: PMC2223382.
      Citations: 78     Fields:    Translation:AnimalsCells
    7. Ingvarsdottir K, Edwards C, Lee MG, Lee JS, Schultz DC, Shilatifard A, Shiekhattar R, Berger SL. Histone H3 K4 demethylation during activation and attenuation of GAL1 transcription in Saccharomyces cerevisiae. Mol Cell Biol. 2007 Nov; 27(22):7856-64. PMID: 17875926; PMCID: PMC2169161.
      Citations: 26     Fields:    Translation:AnimalsCells
    8. Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. p53 is regulated by the lysine demethylase LSD1. Nature. 2007 Sep 06; 449(7158):105-8. PMID: 17805299.
      Citations: 347     Fields:    Translation:HumansCells
    9. Lee MG, Villa R, Trojer P, Norman J, Yan KP, Reinberg D, Di Croce L, Shiekhattar R. Demethylation of H3K27 regulates polycomb recruitment and H2A ubiquitination. Science. 2007 Oct 19; 318(5849):447-50. PMID: 17761849.
      Citations: 364     Fields:    Translation:HumansCells
    10. Eissenberg JC, Lee MG, Schneider J, Ilvarsonn A, Shiekhattar R, Shilatifard A. The trithorax-group gene in Drosophila little imaginal discs encodes a trimethylated histone H3 Lys4 demethylase. Nat Struct Mol Biol. 2007 Apr; 14(4):344-6. PMID: 17351630.
      Citations: 56     Fields:    Translation:AnimalsCells
    11. Lee MG, Norman J, Shilatifard A, Shiekhattar R. Physical and functional association of a trimethyl H3K4 demethylase and Ring6a/MBLR, a polycomb-like protein. Cell. 2007 Mar 09; 128(5):877-87. PMID: 17320162.
      Citations: 116     Fields:    Translation:HumansCells
    12. Lee MG, Wynder C, Norman J, Shiekhattar R. Isolation and characterization of histone H3 lysine 4 demethylase-containing complexes. Methods. 2006 Dec; 40(4):327-30. PMID: 17101444; PMCID: PMC4682359.
      Citations: 5     Fields:    Translation:HumansCells
    13. Nicolas E, Lee MG, Hakimi MA, Cam HP, Grewal SI, Shiekhattar R. Fission yeast homologs of human histone H3 lysine 4 demethylase regulate a common set of genes with diverse functions. J Biol Chem. 2006 Nov 24; 281(47):35983-8. PMID: 16990277.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    14. Lee MG, Wynder C, Bochar DA, Hakimi MA, Cooch N, Shiekhattar R. Functional interplay between histone demethylase and deacetylase enzymes. Mol Cell Biol. 2006 Sep; 26(17):6395-402. PMID: 16914725; PMCID: PMC1592851.
      Citations: 111     Fields:    Translation:HumansCells
    15. Lee MG, Wynder C, Schmidt DM, McCafferty DG, Shiekhattar R. Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications. Chem Biol. 2006 Jun; 13(6):563-7. PMID: 16793513.
      Citations: 190     Fields:    Translation:HumansCells
    16. Lee MG, Wynder C, Cooch N, Shiekhattar R. An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation. Nature. 2005 Sep 15; 437(7057):432-5. PMID: 16079794.
      Citations: 346     Fields:    Translation:HumansCells
    17. Lee MG, Pedersen PL. Glucose metabolism in cancer: importance of transcription factor-DNA interactions within a short segment of the proximal region og the type II hexokinase promoter. J Biol Chem. 2003 Oct 17; 278(42):41047-58. PMID: 12893819.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    18. Histone methylation modifiers in cellular signaling pathways. Cellular and Molecular Life Sciences.
    19. An essential role for UTX in resolution and activation of bivalent promoters. Nucleic Acids Research. 44:3659-3674.
    20. Histone H3 lysine 4 methyltransferases and demethylases in self-renewal and differentiation of stem cells. Cell and Bioscience. 3.
    21. ZMYND8 Reads the Dual Histone Mark H3K4me1-H3K14ac to Antagonize the Expression of Metastasis-Linked Genes. Molecular Cell.
    22. JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis. Cancer Research. 76:831-843.
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