TitleAssociate Professor
InstitutionMD Anderson
Address6767 Bertner St
Houston TX 77030-2603
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. De A, Lattier JM, Morales JE, Kelly JR, Zheng X, Chen Z, Sebastian S, Nassiri Toosi Z, Huse JT, Lang FF, McCarty JH. Glial Cell Adhesion Molecule (GlialCAM) Determines Proliferative versus Invasive Cell States in Glioblastoma. J Neurosci. 2023 11 22; 43(47):8043-8057. PMID: 37722850; PMCID: PMC10669794.
      Citations: 1     Fields:    Translation:Humans
    2. McCarty JH. MMP9 Clears the Way for Metastatic Cell Penetration Across the Blood-Brain Barrier. Cancer Res. 2023 04 14; 83(8):1167-1169. PMID: 37057598.
      Citations:    Fields:    Translation:HumansCells
    3. Chen Z, Kelly JR, Morales JE, Sun RC, De A, Burkin DJ, McCarty JH. The alpha7 integrin subunit in astrocytes promotes endothelial blood-brain barrier integrity. Development. 2023 03 15; 150(6). PMID: 36960827; PMCID: PMC10112902.
      Citations:    Fields:    Translation:AnimalsCells
    4. De A, Morales JE, Chen Z, Sebastian S, McCarty JH. The ?8 integrin cytoplasmic domain activates extracellular matrix adhesion to promote brain neurovascular development. Development. 2022 03 15; 149(6). PMID: 35217866; PMCID: PMC8977100.
      Citations:    Fields:    Translation:AnimalsCells
    5. Morales JE, De A, Miller AA, Chen Z, McCarty JH. Mlc1-Expressing Perivascular Astrocytes Promote Blood-Brain Barrier Integrity. J Neurosci. 2022 02 23; 42(8):1406-1416. PMID: 34965971; PMCID: PMC8883848.
      Citations: 1     Fields:    Translation:AnimalsCells
    6. Lattier JM, De A, Chen Z, Morales JE, Lang FF, Huse JT, McCarty JH. Megalencephalic leukoencephalopathy with subcortical cysts 1 (MLC1) promotes glioblastoma cell invasion in the brain microenvironment. Oncogene. 2020 12; 39(50):7253-7264. PMID: 33040087; PMCID: PMC7736299.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Yosef N, Xi Y, McCarty JH. Isolation and transcriptional characterization of mouse perivascular astrocytes. PLoS One. 2020; 15(10):e0240035. PMID: 33031376; PMCID: PMC7544046.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Chen Z, Morales JE, Avci N, Guerrero PA, Rao G, Seo JH, McCarty JH. The vascular endothelial cell-expressed prion protein doppel promotes angiogenesis and blood-brain barrier development. Development. 2020 09 23; 147(18). PMID: 32895288; PMCID: PMC7522017.
      Citations: 6     Fields:    Translation:AnimalsCells
    9. Catignas KK, Frick LR, Pellegatta M, Hurley E, Kolb Z, Addabbo K, McCarty JH, Hynes RO, van der Flier A, Poitelon Y, Wrabetz L, Feltri ML. aV integrins in Schwann cells promote attachment to axons, but are dispensable in vivo. Glia. 2021 01; 69(1):91-108. PMID: 32744761; PMCID: PMC8491627.
      Citations: 2     Fields:    Translation:AnimalsCells
    10. McCarty JH. av?8 integrin adhesion and signaling pathways in development, physiology and disease. J Cell Sci. 2020 06 15; 133(12). PMID: 32540905; PMCID: PMC7328133.
      Citations: 14     Fields:    Translation:HumansCells
    11. Tiwary S, Morales JE, Kwiatkowski SC, Lang FF, Rao G, McCarty JH. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a. Sci Rep. 2018 05 29; 8(1):8267. PMID: 29844613; PMCID: PMC5974340.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    12. Chen Z, Morales JE, Guerrero PA, Sun H, McCarty JH. PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells. Cancer Res. 2018 07 15; 78(14):3809-3822. PMID: 29743287; PMCID: PMC6050134.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    13. Guerrero PA, McCarty JH. Integrins in Vascular Development and Pathology. Adv Pharmacol. 2018; 81:129-153. PMID: 29310797.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    14. Toutounchian JJ, McCarty JH. Selective expression of eGFP in mouse perivascular astrocytes by modification of the Mlc1 gene using T2A-based ribosome skipping. Genesis. 2017 10; 55(10). PMID: 28929580; PMCID: PMC5771503.
      Citations: 4     Fields:    Translation:AnimalsCells
    15. Kwiatkowski SC, Guerrero PA, Hirota S, Chen Z, Morales JE, Aghi M, McCarty JH. Neuropilin-1 modulates TGF? signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy. PLoS One. 2017; 12(9):e0185065. PMID: 28938007; PMCID: PMC5609745.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    16. Cheerathodi M, Avci NG, Guerrero PA, Tang LK, Popp J, Morales JE, Chen Z, Carnero A, Lang FF, Ballif BA, Rivera GM, McCarty JH. The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma. Mol Cancer Res. 2016 12; 14(12):1277-1287. PMID: 27655131; PMCID: PMC5136334.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    17. Hirota S, Clements TP, Tang LK, Morales JE, Lee HS, Oh SP, Rivera GM, Wagner DS, McCarty JH. Neuropilin 1 balances ?8 integrin-activated TGF? signaling to control sprouting angiogenesis in the brain. Development. 2015 Dec 15; 142(24):4363-73. PMID: 26586223; PMCID: PMC4689212.
      Citations: 37     Fields:    Translation:AnimalsCells
    18. Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015 Nov 05; 527(7576):100-104. PMID: 26479035; PMCID: PMC4819404.
      Citations: 509     Fields:    Translation:HumansAnimalsCells
    19. Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH, Paidassi H. Protein tyrosine phosphatase-PEST and ?8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol. 2015 Apr; 35(8):1401-13. PMID: 25666508; PMCID: PMC4372704.
      Citations: 20     Fields:    Translation:AnimalsCells
    20. Lee HS, McCarty JH. Inducible gene deletion in glial cells to study angiogenesis in the central nervous system. Methods Mol Biol. 2014; 1135:261-74. PMID: 24510871.
      Citations: 2     Fields:    Translation:AnimalsCells
    21. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24. PMID: 24216753; PMCID: PMC3855865.
      Citations: 350     Fields:    Translation:AnimalsCells
    22. Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013 Dec; 24(24):3857-68. PMID: 24152735; PMCID: PMC3861082.
      Citations: 13     Fields:    Translation:AnimalsCells
    23. McCarty JH. Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET? Clin Cancer Res. 2013 Apr 01; 19(7):1631-3. PMID: 23403631; PMCID: PMC3618531.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    24. Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH. av?8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell. 2013 Feb; 24(4):474-82. PMID: 23283986; PMCID: PMC3571870.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    25. Jung Y, McCarty JH. Band 4.1 proteins regulate integrin-dependent cell spreading. Biochem Biophys Res Commun. 2012 Oct 05; 426(4):578-84. PMID: 22982319; PMCID: PMC3467326.
      Citations: 14     Fields:    Translation:AnimalsCells
    26. Allinson KR, Lee HS, Fruttiger M, McCarty JH, McCarty J, Arthur HM. Endothelial expression of TGF? type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system. PLoS One. 2012; 7(6):e39336. PMID: 22745736; PMCID: PMC3383742.
      Citations: 26     Fields:    Translation:AnimalsCells
    27. Mobley AK, McCarty JH. Use of Cre-lox technology to analyze integrin functions in astrocytes. Methods Mol Biol. 2012; 814:555-70. PMID: 22144332.
      Citations: 1     Fields:    Translation:AnimalsCells
    28. Hirota S, Liu Q, Lee HS, Hossain MG, Lacy-Hulbert A, McCarty JH. The astrocyte-expressed integrin av?8 governs blood vessel sprouting in the developing retina. Development. 2011 Dec; 138(23):5157-66. PMID: 22069187; PMCID: PMC3253036.
      Citations: 35     Fields:    Translation:AnimalsCells
    29. Nguyen HL, Lee YJ, Shin J, Lee E, Park SO, McCarty JH, Oh SP. TGF-? signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab Invest. 2011 Nov; 91(11):1554-63. PMID: 21876535; PMCID: PMC3802535.
      Citations: 44     Fields:    Translation:AnimalsCells
    30. Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH. Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by ?8 integrin. Cancer Res. 2011 Oct 15; 71(20):6371-81. PMID: 21859829; PMCID: PMC3193578.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    31. Mobley AK, McCarty JH. ?8 integrin is essential for neuroblast migration in the rostral migratory stream. Glia. 2011 Nov; 59(11):1579-87. PMID: 21674628.
      Citations: 14     Fields:    Translation:AnimalsCells
    32. Hsu A, Esmaeli B, Hayek B, Hossain MG, Shinder R, Lazar AJ, McCarty JH. Analysis of av integrin protein expression in human eyelid and periorbital squamous cell carcinomas. J Cutan Pathol. 2011 Jul; 38(7):570-5. PMID: 21375561.
      Citations: 2     Fields:    Translation:Humans
    33. Khan S, Lakhe-Reddy S, McCarty JH, Sorenson CM, Sheibani N, Reichardt LF, Kim JH, Wang B, Sedor JR, Schelling JR. Mesangial cell integrin av?8 provides glomerular endothelial cell cytoprotection by sequestering TGF-? and regulating PECAM-1. Am J Pathol. 2011 Feb; 178(2):609-20. PMID: 21281793; PMCID: PMC3070557.
      Citations: 31     Fields:    Translation:AnimalsCells
    34. Jung Y, Kissil JL, McCarty JH. ?8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart. Dev Dyn. 2011 Jan; 240(1):271-7. PMID: 21181944.
      Citations: 13     Fields:    Translation:AnimalsCells
    35. Tchaicha JH, Mobley AK, Hossain MG, Aldape KD, McCarty JH. A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. Oncogene. 2010 Aug 05; 29(31):4460-72. PMID: 20531304; PMCID: PMC3037767.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    36. Langley RR, Fan D, Guo L, Zhang C, Lin Q, Brantley EC, McCarty JH, Fidler IJ. Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis. Int J Oncol. 2009 Oct; 35(4):665-72. PMID: 19724901; PMCID: PMC2882684.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    37. Mobley AK, Tchaicha JH, Shin J, Hossain MG, McCarty JH. Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. J Cell Sci. 2009 Jun 01; 122(Pt 11):1842-51. PMID: 19461074; PMCID: PMC2694619.
      Citations: 44     Fields:    Translation:AnimalsCells
    38. McCarty JH. Cell adhesion and signaling networks in brain neurovascular units. Curr Opin Hematol. 2009 May; 16(3):209-14. PMID: 19318941; PMCID: PMC2706115.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    39. McCarty JH. Integrin-mediated regulation of neurovascular development, physiology and disease. Cell Adh Migr. 2009 Apr-Jun; 3(2):211-5. PMID: 19372738; PMCID: PMC2679889.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    40. McCarty JH. Alphav integrins lead the way for colorectal metastases. Clin Cancer Res. 2008 Oct 15; 14(20):6351-3. PMID: 18927272; PMCID: PMC2688736.
      Citations: 7     Fields:    Translation:Humans
    41. McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol. 2008 Jun; 172(6):1740-7. PMID: 18467691; PMCID: PMC2408432.
      Citations: 13     Fields:    Translation:AnimalsCells
    42. Yi C, McCarty JH, Troutman SA, Eckman MS, Bronson RT, Kissil JL. Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer. Mol Cell Biol. 2005 Nov; 25(22):10052-9. PMID: 16260618; PMCID: PMC1280276.
      Citations: 20     Fields:    Translation:AnimalsCells
    43. McCarty JH, Cook AA, Hynes RO. An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13479-83. PMID: 16157875; PMCID: PMC1224645.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    44. McCarty JH. Cell biology of the neurovascular unit: implications for drug delivery across the blood-brain barrier. Assay Drug Dev Technol. 2005 Feb; 3(1):89-95. PMID: 15798399.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    45. McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Hynes RO, Roes J. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan; 132(1):165-76. PMID: 15576410.
      Citations: 117     Fields:    Translation:HumansAnimalsCells
    46. McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol. 2002 Nov; 22(21):7667-77. PMID: 12370313; PMCID: PMC135679.
      Citations: 74     Fields:    Translation:AnimalsCells
    47. Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, Hodivala-Dilke K, Xiao Q. The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol. 2002; 67:143-53. PMID: 12858535.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    48. McCarty JH, Feinstein SC. The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL. J Recept Signal Transduct Res. 1999 Nov; 19(6):953-74. PMID: 10533983.
      Citations: 6     Fields:    Translation:AnimalsCells
    49. McCarty JH. The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events. Bioessays. 1998 Nov; 20(11):913-21. PMID: 9872057.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    50. McCarty JH, Feinstein SC. Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. Oncogene. 1998 Apr 02; 16(13):1691-700. PMID: 9582017.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    51. Esmaeli-Azad B, McCarty JH, Feinstein SC. Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability. J Cell Sci. 1994 Apr; 107 ( Pt 4):869-79. PMID: 8056843.
      Citations: 64     Fields:    Translation:AnimalsCells
    52. Inducible gene deletion in glial cells to study angiogenesis in the central nervous system. 261-274.
    53. Angiogenesis in gliomas. 187-219.
    54. Endothelial cell integrins. 707-713.
    55. Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain. Development (Cambridge). 142:4363-4373.
    56. The cytoskeletal adapter protein spinophilin regulates invadopodia dynamics and tumor cell invasion in glioblastoma. Molecular Cancer Research. 14:1277-1287.
    57. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nature Medicine. 19:1617-1624.
    58. Erratum. Journal of Cell Science. 122.
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