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JOSEPH MCCARTY

TitleAssociate Professor
InstitutionMD Anderson
DepartmentNeurosurgery
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Tiwary S, Morales JE, Kwiatkowski SC, Lang FF, Rao G, McCarty JH. Metastatic Brain Tumors Disrupt the Blood-Brain Barrier and Alter Lipid Metabolism by Inhibiting Expression of the Endothelial Cell Fatty Acid Transporter Mfsd2a. Sci Rep. 2018 05 29; 8(1):8267. PMID: 29844613.
      View in: PubMed
    2. Chen Z, Morales JE, Guerrero PA, Sun H, McCarty JH. PTPN12/PTP-PEST Regulates Phosphorylation-Dependent Ubiquitination and Stability of Focal Adhesion Substrates in Invasive Glioblastoma Cells. Cancer Res. 2018 07 15; 78(14):3809-3822. PMID: 29743287.
      View in: PubMed
    3. Guerrero PA, McCarty JH. Integrins in Vascular Development and Pathology. Adv Pharmacol. 2018; 81:129-153. PMID: 29310797.
      View in: PubMed
    4. Toutounchian JJ, McCarty JH. Selective expression of eGFP in mouse perivascular astrocytes by modification of the Mlc1 gene using T2A-based ribosome skipping. Genesis. 2017 10; 55(10). PMID: 28929580.
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    5. Kwiatkowski SC, Guerrero PA, Hirota S, Chen Z, Morales JE, Aghi M, McCarty JH. Neuropilin-1 modulates TGFß signaling to drive glioblastoma growth and recurrence after anti-angiogenic therapy. PLoS One. 2017; 12(9):e0185065. PMID: 28938007.
      View in: PubMed
    6. Clements TP, Tandon B, Lintel HA, McCarty JH, Wagner DS. RICE CRISPR: Rapidly increased cut ends by an exonuclease Cas9 fusion in zebrafish. Genesis. 2017 08; 55(8). PMID: 28653435.
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    7. Cheerathodi M, Avci NG, Guerrero PA, Tang LK, Popp J, Morales JE, Chen Z, Carnero A, Lang FF, Ballif BA, Rivera GM, McCarty JH. The Cytoskeletal Adapter Protein Spinophilin Regulates Invadopodia Dynamics and Tumor Cell Invasion in Glioblastoma. Mol Cancer Res. 2016 12; 14(12):1277-1287. PMID: 27655131.
      View in: PubMed
    8. Hirota S, Clements TP, Tang LK, Morales JE, Lee HS, Oh SP, Rivera GM, Wagner DS, McCarty JH. Neuropilin 1 balances ß8 integrin-activated TGFß signaling to control sprouting angiogenesis in the brain. Development. 2015 Dec 15; 142(24):4363-73. PMID: 26586223.
      View in: PubMed
    9. Zhang L, Zhang S, Yao J, Lowery FJ, Zhang Q, Huang WC, Li P, Li M, Wang X, Zhang C, Wang H, Ellis K, Cheerathodi M, McCarty JH, Palmieri D, Saunus J, Lakhani S, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. Microenvironment-induced PTEN loss by exosomal microRNA primes brain metastasis outgrowth. Nature. 2015 Nov 05; 527(7576):100-104. PMID: 26479035.
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    10. Lee HS, Cheerathodi M, Chaki SP, Reyes SB, Zheng Y, Lu Z, Paidassi H, DerMardirossian C, Lacy-Hulbert A, Rivera GM, McCarty JH. Protein tyrosine phosphatase-PEST and ß8 integrin regulate spatiotemporal patterns of RhoGDI1 activation in migrating cells. Mol Cell Biol. 2015 Apr; 35(8):1401-13. PMID: 25666508.
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    11. Lee HS, McCarty JH. Inducible gene deletion in glial cells to study angiogenesis in the central nervous system. Methods Mol Biol. 2014; 1135:261-74. PMID: 24510871.
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    12. Henderson NC, Arnold TD, Katamura Y, Giacomini MM, Rodriguez JD, McCarty JH, Pellicoro A, Raschperger E, Betsholtz C, Ruminski PG, Griggs DW, Prinsen MJ, Maher JJ, Iredale JP, Lacy-Hulbert A, Adams RH, Sheppard D. Targeting of av integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nat Med. 2013 Dec; 19(12):1617-24. PMID: 24216753.
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    13. Narayanan AS, Reyes SB, Um K, McCarty JH, Tolias KF. The Rac-GAP Bcr is a novel regulator of the Par complex that controls cell polarity. Mol Biol Cell. 2013 Dec; 24(24):3857-68. PMID: 24152735.
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    14. McCarty JH. Glioblastoma resistance to anti-VEGF therapy: has the challenge been MET? Clin Cancer Res. 2013 Apr 01; 19(7):1631-3. PMID: 23403631.
      View in: PubMed
    15. Reyes SB, Narayanan AS, Lee HS, Tchaicha JH, Aldape KD, Lang FF, Tolias KF, McCarty JH. avß8 integrin interacts with RhoGDI1 to regulate Rac1 and Cdc42 activation and drive glioblastoma cell invasion. Mol Biol Cell. 2013 Feb; 24(4):474-82. PMID: 23283986.
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    16. Jung Y, McCarty JH. Band 4.1 proteins regulate integrin-dependent cell spreading. Biochem Biophys Res Commun. 2012 Oct 05; 426(4):578-84. PMID: 22982319.
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    17. Allinson KR, Lee HS, Fruttiger M, McCarty JH, McCarty J, Arthur HM. Endothelial expression of TGFß type II receptor is required to maintain vascular integrity during postnatal development of the central nervous system. PLoS One. 2012; 7(6):e39336. PMID: 22745736.
      View in: PubMed
    18. Mobley AK, McCarty JH. Use of Cre-lox technology to analyze integrin functions in astrocytes. Methods Mol Biol. 2012; 814:555-70. PMID: 22144332.
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    19. Hirota S, Liu Q, Lee HS, Hossain MG, Lacy-Hulbert A, McCarty JH. The astrocyte-expressed integrin avß8 governs blood vessel sprouting in the developing retina. Development. 2011 Dec; 138(23):5157-66. PMID: 22069187.
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    20. Nguyen HL, Lee YJ, Shin J, Lee E, Park SO, McCarty JH, Oh SP. TGF-ß signaling in endothelial cells, but not neuroepithelial cells, is essential for cerebral vascular development. Lab Invest. 2011 Nov; 91(11):1554-63. PMID: 21876535.
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    21. Tchaicha JH, Reyes SB, Shin J, Hossain MG, Lang FF, McCarty JH. Glioblastoma angiogenesis and tumor cell invasiveness are differentially regulated by ß8 integrin. Cancer Res. 2011 Oct 15; 71(20):6371-81. PMID: 21859829.
      View in: PubMed
    22. Mobley AK, McCarty JH. ß8 integrin is essential for neuroblast migration in the rostral migratory stream. Glia. 2011 Nov; 59(11):1579-87. PMID: 21674628.
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    23. Hsu A, Esmaeli B, Hayek B, Hossain MG, Shinder R, Lazar AJ, McCarty JH. Analysis of av integrin protein expression in human eyelid and periorbital squamous cell carcinomas. J Cutan Pathol. 2011 Jul; 38(7):570-5. PMID: 21375561.
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    24. Khan S, Lakhe-Reddy S, McCarty JH, Sorenson CM, Sheibani N, Reichardt LF, Kim JH, Wang B, Sedor JR, Schelling JR. Mesangial cell integrin avß8 provides glomerular endothelial cell cytoprotection by sequestering TGF-ß and regulating PECAM-1. Am J Pathol. 2011 Feb; 178(2):609-20. PMID: 21281793.
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    25. Jung Y, Kissil JL, McCarty JH. ß8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart. Dev Dyn. 2011 Jan; 240(1):271-7. PMID: 21181944.
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    26. Tchaicha JH, Mobley AK, Hossain MG, Aldape KD, McCarty JH. A mosaic mouse model of astrocytoma identifies alphavbeta8 integrin as a negative regulator of tumor angiogenesis. Oncogene. 2010 Aug 05; 29(31):4460-72. PMID: 20531304.
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    27. Langley RR, Fan D, Guo L, Zhang C, Lin Q, Brantley EC, McCarty JH, Fidler IJ. Generation of an immortalized astrocyte cell line from H-2Kb-tsA58 mice to study the role of astrocytes in brain metastasis. Int J Oncol. 2009 Oct; 35(4):665-72. PMID: 19724901.
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    28. Mobley AK, Tchaicha JH, Shin J, Hossain MG, McCarty JH. Beta8 integrin regulates neurogenesis and neurovascular homeostasis in the adult brain. J Cell Sci. 2009 Jun 01; 122(Pt 11):1842-51. PMID: 19461074.
      View in: PubMed
    29. McCarty JH. Cell adhesion and signaling networks in brain neurovascular units. Curr Opin Hematol. 2009 May; 16(3):209-14. PMID: 19318941.
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    30. McCarty JH. Integrin-mediated regulation of neurovascular development, physiology and disease. Cell Adh Migr. 2009 Apr-Jun; 3(2):211-5. PMID: 19372738.
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    31. McCarty JH. Alphav integrins lead the way for colorectal metastases. Clin Cancer Res. 2008 Oct 15; 14(20):6351-3. PMID: 18927272.
      View in: PubMed
    32. McCarty JH, Barry M, Crowley D, Bronson RT, Lacy-Hulbert A, Hynes RO. Genetic ablation of alphav integrins in epithelial cells of the eyelid skin and conjunctiva leads to squamous cell carcinoma. Am J Pathol. 2008 Jun; 172(6):1740-7. PMID: 18467691.
      View in: PubMed
    33. Yi C, McCarty JH, Troutman SA, Eckman MS, Bronson RT, Kissil JL. Loss of the putative tumor suppressor band 4.1B/Dal1 gene is dispensable for normal development and does not predispose to cancer. Mol Cell Biol. 2005 Nov; 25(22):10052-9. PMID: 16260618.
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    34. McCarty JH, Cook AA, Hynes RO. An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain. Proc Natl Acad Sci U S A. 2005 Sep 20; 102(38):13479-83. PMID: 16157875.
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    35. McCarty JH. Cell biology of the neurovascular unit: implications for drug delivery across the blood-brain barrier. Assay Drug Dev Technol. 2005 Feb; 3(1):89-95. PMID: 15798399.
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    36. McCarty JH, Lacy-Hulbert A, Charest A, Bronson RT, Crowley D, Housman D, Savill J, Roes J, Hynes RO. Selective ablation of alphav integrins in the central nervous system leads to cerebral hemorrhage, seizures, axonal degeneration and premature death. Development. 2005 Jan; 132(1):165-76. PMID: 15576410.
      View in: PubMed
    37. McCarty JH, Monahan-Earley RA, Brown LF, Keller M, Gerhardt H, Rubin K, Shani M, Dvorak HF, Wolburg H, Bader BL, Dvorak AM, Hynes RO. Defective associations between blood vessels and brain parenchyma lead to cerebral hemorrhage in mice lacking alphav integrins. Mol Cell Biol. 2002 Nov; 22(21):7667-77. PMID: 12370313.
      View in: PubMed
    38. Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, Hodivala-Dilke K, Xiao Q. The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol. 2002; 67:143-53. PMID: 12858535.
      View in: PubMed
    39. McCarty JH, Feinstein SC. The TrkB receptor tyrosine kinase regulates cellular proliferation via signal transduction pathways involving SHC, PLCgamma, and CBL. J Recept Signal Transduct Res. 1999 Nov; 19(6):953-74. PMID: 10533983.
      View in: PubMed
    40. McCarty JH. The Nck SH2/SH3 adaptor protein: a regulator of multiple intracellular signal transduction events. Bioessays. 1998 Nov; 20(11):913-21. PMID: 9872057.
      View in: PubMed
    41. McCarty JH, Feinstein SC. Activation loop tyrosines contribute varying roles to TrkB autophosphorylation and signal transduction. Oncogene. 1998 Apr 02; 16(13):1691-700. PMID: 9582017.
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    42. Esmaeli-Azad B, McCarty JH, Feinstein SC. Sense and antisense transfection analysis of tau function: tau influences net microtubule assembly, neurite outgrowth and neuritic stability. J Cell Sci. 1994 Apr; 107 ( Pt 4):869-79. PMID: 8056843.
      View in: PubMed
    43. Inducible gene deletion in glial cells to study angiogenesis in the central nervous system. 261-274.
    44. Angiogenesis in gliomas. 187-219.
    45. Endothelial cell integrins. 707-713.
    46. Neuropilin 1 balances β8 integrin-activated TGFβ signaling to control sprouting angiogenesis in the brain. Development (Cambridge). 142:4363-4373.
    47. The cytoskeletal adapter protein spinophilin regulates invadopodia dynamics and tumor cell invasion in glioblastoma. Molecular Cancer Research. 14:1277-1287.
    48. Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs. Nature Medicine. 19:1617-1624.
    49. Erratum. Journal of Cell Science. 122.
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