TitleAssistant Professor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1901 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Morse BL, Chen LH, Catlow JT, Fallon JK, Smith PC, Hillgren KM. Expansion of Knowledge on OCT1 Variant Activity In Vitro and In Vivo Using Oct1/2-/- Mice. Front Pharmacol. 2021; 12:631793. PMID: 33658943.
    2. Morse BL, Kolur A, Hudson LR, Hogan AT, Chen LH, Brackman RM, Sawada GA, Fallon JK, Smith PC, Hillgren KM. Pharmacokinetics of Organic Cation Transporter 1 (OCT1) Substrates in Oct1/2 Knockout Mice and Species Difference in Hepatic OCT1-Mediated Uptake. Drug Metab Dispos. 2020 02; 48(2):93-105. PMID: 31771949.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    3. Olsen JB, Cao XJ, Han B, Chen LH, Horvath A, Richardson TI, Campbell RM, Garcia BA, Nguyen H. Quantitative Profiling of the Activity of Protein Lysine Methyltransferase SMYD2 Using SILAC-Based Proteomics. Mol Cell Proteomics. 2016 Mar; 15(3):892-905. PMID: 26750096.
      Citations: 35     Fields:    Translation:HumansCells
    4. Nguyen H, Allali-Hassani A, Antonysamy S, Chang S, Chen LH, Curtis C, Emtage S, Fan L, Gheyi T, Li F, Liu S, Martin JR, Mendel D, Olsen JB, Pelletier L, Shatseva T, Wu S, Zhang FF, Arrowsmith CH, Brown PJ, Campbell RM, Garcia BA, Barsyte-Lovejoy D, Mader M, Vedadi M. LLY-507, a Cell-active, Potent, and Selective Inhibitor of Protein-lysine Methyltransferase SMYD2. J Biol Chem. 2015 May 29; 290(22):13641-53. PMID: 25825497.
      Citations: 40     Fields:    Translation:HumansCells
    5. Chen LS, Keating MJ, Gandhi V. Blood collection methods affect cellular protein integrity: implications for clinical trial biomarkers and ZAP-70 in CLL. Blood. 2014 Aug 14; 124(7):1192-5. PMID: 25124785.
      Citations: 2     Fields:    Translation:Humans
    6. Yang Q, Chen LS, Gandhi V. Mechanism-based combinations with Pim kinase inhibitors in cancer treatments. Curr Pharm Des. 2014; 20(42):6670-81. PMID: 25341939.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Patel V, Chen LS, Wierda WG, Balakrishnan K, Gandhi V. Impact of bone marrow stromal cells on Bcl-2 family members in chronic lymphocytic leukemia. Leuk Lymphoma. 2014 Apr; 55(4):899-910. PMID: 23837491.
      Citations: 12     Fields:    Translation:HumansCells
    8. Yang Q, Chen LS, Neelapu SS, Gandhi V. Combination of Pim kinase inhibitor SGI-1776 and bendamustine in B-cell lymphoma. Clin Lymphoma Myeloma Leuk. 2013 Sep; 13 Suppl 2:S355-62. PMID: 24290221.
      Citations: 8     Fields:    Translation:HumansCells
    9. Cervantes-Gomez F, Chen LS, Orlowski RZ, Gandhi V. Biological effects of the Pim kinase inhibitor, SGI-1776, in multiple myeloma. Clin Lymphoma Myeloma Leuk. 2013 Sep; 13 Suppl 2:S317-29. PMID: 23988451.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    10. Ming W, Ma W, Chen LH, Volk C, Michael MD, Xu Y, Zhang F, Wang X. Development and validation of a 96-well cellular assay for the discovery of ALDH1A1 inhibitors. Assay Drug Dev Technol. 2013 Jul; 11(6):388-95. PMID: 23957476.
      Citations: 1     Fields:    Translation:HumansCells
    11. Yang Q, Chen LS, Neelapu SS, Miranda RN, Medeiros LJ, Gandhi V. Transcription and translation are primary targets of Pim kinase inhibitor SGI-1776 in mantle cell lymphoma. Blood. 2012 Oct 25; 120(17):3491-500. PMID: 22955922.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Pillai RN, Chen LS, Ayres ML, Nowak BJ, Thomas MW, Shpall EJ, Keating MJ, Gandhi V. Multifaceted actions of 8-amino-adenosine kill BCR-ABL positive cells. Leuk Lymphoma. 2012 Oct; 53(10):2024-32. PMID: 22448923.
      Citations: 1     Fields:    Translation:HumansCells
    13. Stellrecht CM, Chen LS. Transcription inhibition as a therapeutic target for cancer. Cancers (Basel). 2011 Nov 23; 3(4):4170-90. PMID: 24213132.
      Citations: 12     
    14. Chen LS, Redkar S, Taverna P, Cortes JE, Gandhi V. Mechanisms of cytotoxicity to Pim kinase inhibitor, SGI-1776, in acute myeloid leukemia. Blood. 2011 Jul 21; 118(3):693-702. PMID: 21628411.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    15. Chen LS, Balakrishnan K, Gandhi V. Inflammation and survival pathways: chronic lymphocytic leukemia as a model system. Biochem Pharmacol. 2010 Dec 15; 80(12):1936-45. PMID: 20696142.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Zhang S, Chen L, Jung EJ, Calin GA. Targeting microRNAs with small molecules: from dream to reality. Clin Pharmacol Ther. 2010 Jun; 87(6):754-8. PMID: 20428111.
      Citations: 44     Fields:    Translation:HumansAnimals
    17. Chen LS, Du-Cuny L, Vethantham V, Hawke DH, Manley JL, Zhang S, Gandhi V. Chain termination and inhibition of mammalian poly(A) polymerase by modified ATP analogues. Biochem Pharmacol. 2010 Mar 01; 79(5):669-77. PMID: 19814999.
      Citations: 13     Fields:    Translation:Animals
    18. Chen LS, Redkar S, Bearss D, Wierda WG, Gandhi V. Pim kinase inhibitor, SGI-1776, induces apoptosis in chronic lymphocytic leukemia cells. Blood. 2009 Nov 05; 114(19):4150-7. PMID: 19734450.
      Citations: 78     Fields:    Translation:HumansCells
    19. Chen LS, Nowak BJ, Ayres ML, Krett NL, Rosen ST, Zhang S, Gandhi V. Inhibition of ATP synthase by chlorinated adenosine analogue. Biochem Pharmacol. 2009 Sep 15; 78(6):583-91. PMID: 19477165.
      Citations: 13     Fields:    Translation:Cells
    20. Gandhi V, Balakrishnan K, Chen LS. Mcl-1: the 1 in CLL. Blood. 2008 Nov 01; 112(9):3538-40. PMID: 18948586.
      Citations: 16     Fields:    
    21. Chen LS, Plunkett W, Gandhi V. Polyadenylation inhibition by the triphosphates of deoxyadenosine analogues. Leuk Res. 2008 Oct; 32(10):1573-81. PMID: 18433867.
      Citations: 4     Fields:    Translation:Cells
    22. Chen LS, Stellrecht CM, Gandhi V. RNA-directed agent, cordycepin, induces cell death in multiple myeloma cells. Br J Haematol. 2008 Mar; 140(6):682-391. PMID: 18205859.
      Citations: 22     Fields:    Translation:HumansCells
    23. Chen LS, Sheppard TL. Chain termination and inhibition of Saccharomyces cerevisiae poly(A) polymerase by C-8-modified ATP analogs. J Biol Chem. 2004 Sep 24; 279(39):40405-11. PMID: 15265873.
      Citations: 18     Fields:    Translation:AnimalsCells
    24. Chen LS, Bahr MH, Sheppard TL. Effects of 8-chlorodeoxyadenosine on DNA synthesis by the Klenow fragment of DNA polymerase I. Bioorg Med Chem Lett. 2003 May 05; 13(9):1509-12. PMID: 12699743.
      Citations: 1     Fields:    Translation:Cells
    25. Chen LS, Sheppard TL. Synthesis and hybridization properties of RNA containing 8-chloroadenosine. Nucleosides Nucleotides Nucleic Acids. 2002; 21(8-9):599-617. PMID: 12484453.
      Citations: 5     Fields:    Translation:Cells
    26. Protein profiling identifies mTOR pathway modulation and cytostatic effects of Pim kinase inhibitor, AZD1208, in acute myeloid leukemia. Leukemia and Lymphoma. 1-11.
    27. Synthesis, characterization, redox properties, and representative X-ray structures of four- and five-coordinate copper(II) complexes with polydentate aminopyridine ligands. Inorganica Chimica Acta. 324:1-15.
    28. Pim kinases in aml. 177-199.
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