TitleAssistant Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPO Box 389
Smithville TX 78957-0389
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gao G, Hausmann S, Flores NM, Benitez AM, Shen J, Yang X, Person MD, Gayatri S, Cheng D, Lu Y, Liu B, Mazur PK, Bedford MT. The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer. Nat Commun. 2023 01 23; 14(1):363. PMID: 36690626; PMCID: PMC9870865.
      Citations: 1     Fields:    Translation:AnimalsCells
    2. Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Bedford MT, Richard S. Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. J Biol Chem. 2020 12 11; 295(50):17060-17070. PMID: 33008887; PMCID: PMC7863876.
      Citations: 7     Fields:    Translation:AnimalsCells
    3. Haltom AR, Toll SA, Cheng D, Maegawa S, Gopalakrishnan V, Khatua S. Medulloblastoma epigenetics and the path to clinical innovation. J Neurooncol. 2020 Oct; 150(1):35-46. PMID: 32816225; PMCID: PMC8939889.
      Citations: 1     Fields:    Translation:HumansCells
    4. Veazey KJ, Cheng D, Lin K, Villarreal OD, Gao G, Perez-Oquendo M, Van HT, Stratton SA, Green M, Xu H, Lu Y, Bedford MT, Santos MA. CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. Leukemia. 2020 12; 34(12):3269-3285. PMID: 32576962; PMCID: PMC7688486.
      Citations: 6     Fields:    Translation:AnimalsCells
    5. Cheng D, Vemulapalli V, Lu Y, Shen J, Aoyagi S, Fry CJ, Yang Y, Foulds CE, Stossi F, Mancini MA, O'Malley BW, Walker CL, Boyer TG, Bedford MT, Trevi?o LS. CARM1 methylates MED12 to regulate its RNA-binding ability. Life Sci Alliance. 2018 Oct; 1(5):e201800117. PMID: 30456381; PMCID: PMC6238599.
      Citations: 19     Fields:    
    6. Bae N, Su X, Lv J, Cheng D, Sagum C, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Bedford MT, Viviano M, Castellano S, Sbardella G. Developing Spindlin1 small-molecule inhibitors by using protein microarrays. Nat Chem Biol. 2017 Jul; 13(7):750-756. PMID: 28504676; PMCID: PMC5831360.
      Citations: 13     Fields:    Translation:HumansCells
    7. Gayatri S, Cowles MW, Vemulapalli V, Cheng D, Sun ZW, Bedford MT. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Sci Rep. 2016 06 24; 6:28718. PMID: 27338245; PMCID: PMC4919620.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    8. Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G, Castellano S. Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. J Med Chem. 2012 Nov 26; 55(22):9875-90. PMID: 23095008; PMCID: PMC3508294.
      Citations: 5     Fields:    Translation:HumansCells
    9. Cheng D, Vemulapalli V, Bedford MT. Methods applied to the study of protein arginine methylation. Methods Enzymol. 2012; 512:71-92. PMID: 22910203.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    10. Cheng D, Valente S, Castellano S, Sbardella G, Di Santo R, Costi R, Bedford MT, Mai A. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14; 54(13):4928-32. PMID: 21612300; PMCID: PMC3487391.
      Citations: 27     Fields:    Translation:HumansCells
    11. Cheng D, Bedford MT. Xenoestrogens regulate the activity of arginine methyltransferases. Chembiochem. 2011 Jan 24; 12(2):323-9. PMID: 21243720; PMCID: PMC3142315.
      Citations: 9     Fields:    Translation:HumansCells
    12. Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G, Castellano S. Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 01; 5(3):398-414. PMID: 20091730.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    13. Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, Bedford MT. Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010 Jan 08; 285(2):1147-52. PMID: 19897492; PMCID: PMC2801243.
      Citations: 39     Fields:    Translation:AnimalsCells
    14. Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, Altucci L, Mai A. epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem. 2008 Apr 10; 51(7):2279-90. PMID: 18348515.
      Citations: 44     Fields:    Translation:HumansCells
    15. Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep. 2008 Feb; 9(2):193-8. PMID: 18188184; PMCID: PMC2246418.
      Citations: 57     Fields:    Translation:AnimalsCells
    16. Iberg AN, Espejo A, Cheng D, Kim D, Bedford MT, Michaud-Levesque J, Richard S. Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem. 2008 Feb 08; 283(6):3006-3010. PMID: 18077460.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    17. Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem. 2007 Dec 14; 282(50):36444-53. PMID: 17925405.
      Citations: 47     Fields:    Translation:HumansCells
    18. Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT, Mai A. Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem. 2007 Jul; 2(7):987-91. PMID: 17458842.
      Citations: 20     Fields:    Translation:HumansCells
    19. Swiercz R, Cheng D, Kim D, Bedford MT. Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem. 2007 Jun 08; 282(23):16917-23. PMID: 17439947.
      Citations: 53     Fields:    Translation:AnimalsCells
    20. Cheng D, Shaaban S, Bedford MT, C?t? J. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007 Jan 12; 25(1):71-83. PMID: 17218272.
      Citations: 182     Fields:    Translation:HumansAnimalsCells
    21. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford MT, Torchia J. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007 Jan; 27(1):120-34. PMID: 17043108; PMCID: PMC1800659.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    22. Fabbrizio E, Rodriguez C, Chuchana P, Fauquier L, Cheng D, Theillet C, Vandel L, Bedford MT, Sardet C, El Messaoudi S. Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13351-6. PMID: 16938873; PMCID: PMC1569167.
      Citations: 86     Fields:    Translation:AnimalsCells
    23. Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. J Biol Chem. 2004 Jun 04; 279(23):23892-9. PMID: 15056663.
      Citations: 108     Fields:    Translation:HumansCells
    24. Lee J, Cheng D, Bedford MT. Techniques in protein methylation. Methods Mol Biol. 2004; 284:195-208. PMID: 15173617.
      Citations: 6     Fields:    Translation:HumansCells
    25. Cheng D, Shen Q, Nan F, Qian Z, Ye QZ. Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for high-throughput inhibitor screening. Protein Expr Purif. 2003 Jan; 27(1):63-74. PMID: 12509986.
      Citations: 2     Fields:    Translation:HumansCells
    26. Cheng DH, Shen Q, Qian J, Qian Z, Ye QZ. Expression and purification of catalytic domain of human macrophage elastase for high throughput inhibitor screening. Acta Pharmacol Sin. 2002 Feb; 23(2):143-51. PMID: 11866875.
      Citations:    Fields:    Translation:HumansCells
    27. Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav. 1998 Jun; 60(2):377-86. PMID: 9632220.
      Citations: 13     Fields:    Translation:Animals
    28. Xiong ZQ, Cheng DH, Tang XC. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. Zhongguo Yao Li Xue Bao. 1998 Mar; 19(2):128-32. PMID: 10374634.
      Citations: 2     Fields:    Translation:Animals
    29. Cheng DH, Ren H, Tang XC. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport. 1996 Dec 20; 8(1):97-101. PMID: 9051760.
      Citations: 16     Fields:    Translation:Animals
    30. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Scientific Reports. 6.
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