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DONGHANG CHENG

TitleAssistant Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Veazey KJ, Cheng D, Lin K, Villarreal OD, Gao G, Perez-Oquendo M, Van HT, Stratton SA, Green M, Xu H, Lu Y, Bedford MT, Santos MA. CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. Leukemia. 2020 Jun 24. PMID: 32576962.
      View in: PubMed
    2. Cheng D, Vemulapalli V, Lu Y, Shen J, Aoyagi S, Fry CJ, Yang Y, Foulds CE, Stossi F, Treviño LS, Mancini MA, O'Malley BW, Walker CL, Boyer TG, Bedford MT. CARM1 methylates MED12 to regulate its RNA-binding ability. Life Sci Alliance. 2018 Oct; 1(5):e201800117. PMID: 30456381.
      View in: PubMed
    3. Bae N, Viviano M, Su X, Lv J, Cheng D, Sagum C, Castellano S, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Sbardella G, Bedford MT. Developing Spindlin1 small-molecule inhibitors by using protein microarrays. Nat Chem Biol. 2017 Jul; 13(7):750-756. PMID: 28504676.
      View in: PubMed
    4. He Y, Selvaraju S, Curtin ML, Jakob CG, Zhu H, Comess KM, Shaw B, The J, Lima-Fernandes E, Szewczyk MM, Cheng D, Klinge KL, Li HQ, Pliushchev M, Algire MA, Maag D, Guo J, Dietrich J, Panchal SC, Petros AM, Sweis RF, Torrent M, Bigelow LJ, Senisterra G, Li F, Kennedy S, Wu Q, Osterling DJ, Lindley DJ, Gao W, Galasinski S, Barsyte-Lovejoy D, Vedadi M, Buchanan FG, Arrowsmith CH, Chiang GG, Sun C, Pappano WN. The EED protein-protein interaction inhibitor A-395 inactivates the PRC2 complex. Nat Chem Biol. 2017 04; 13(4):389-395. PMID: 28135237.
      View in: PubMed
    5. Gayatri S, Cowles MW, Vemulapalli V, Cheng D, Sun ZW, Bedford MT. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Sci Rep. 2016 06 24; 6:28718. PMID: 27338245.
      View in: PubMed
    6. Castellano S, Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G. Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. J Med Chem. 2012 Nov 26; 55(22):9875-90. PMID: 23095008.
      View in: PubMed
    7. Cheng D, Vemulapalli V, Bedford MT. Methods applied to the study of protein arginine methylation. Methods Enzymol. 2012; 512:71-92. PMID: 22910203.
      View in: PubMed
    8. Cheng D, Valente S, Castellano S, Sbardella G, Di Santo R, Costi R, Bedford MT, Mai A. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14; 54(13):4928-32. PMID: 21612300.
      View in: PubMed
    9. Cheng D, Bedford MT. Xenoestrogens regulate the activity of arginine methyltransferases. Chembiochem. 2011 Jan 24; 12(2):323-9. PMID: 21243720.
      View in: PubMed
    10. Castellano S, Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G. Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 01; 5(3):398-414. PMID: 20091730.
      View in: PubMed
    11. Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, Bedford MT. Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010 Jan 08; 285(2):1147-52. PMID: 19897492.
      View in: PubMed
    12. Mai A, Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, Altucci L. epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem. 2008 Apr 10; 51(7):2279-90. PMID: 18348515.
      View in: PubMed
    13. Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep. 2008 Feb; 9(2):193-8. PMID: 18188184.
      View in: PubMed
    14. Iberg AN, Espejo A, Cheng D, Kim D, Michaud-Levesque J, Richard S, Bedford MT. Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem. 2008 Feb 08; 283(6):3006-10. PMID: 18077460.
      View in: PubMed
    15. Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem. 2007 Dec 14; 282(50):36444-53. PMID: 17925405.
      View in: PubMed
    16. Mai A, Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT. Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem. 2007 Jul; 2(7):987-91. PMID: 17458842.
      View in: PubMed
    17. Swiercz R, Cheng D, Kim D, Bedford MT. Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem. 2007 Jun 08; 282(23):16917-23. PMID: 17439947.
      View in: PubMed
    18. Cheng D, Côté J, Shaaban S, Bedford MT. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007 Jan 12; 25(1):71-83. PMID: 17218272.
      View in: PubMed
    19. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford MT, Torchia J. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007 Jan; 27(1):120-34. PMID: 17043108.
      View in: PubMed
    20. El Messaoudi S, Fabbrizio E, Rodriguez C, Chuchana P, Fauquier L, Cheng D, Theillet C, Vandel L, Bedford MT, Sardet C. Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13351-6. PMID: 16938873.
      View in: PubMed
    21. Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. J Biol Chem. 2004 Jun 04; 279(23):23892-9. PMID: 15056663.
      View in: PubMed
    22. Lee J, Cheng D, Bedford MT. Techniques in protein methylation. Methods Mol Biol. 2004; 284:195-208. PMID: 15173617.
      View in: PubMed
    23. Cheng D, Shen Q, Nan F, Qian Z, Ye QZ. Purification and characterization of catalytic domains of gelatinase A with or without fibronectin insert for high-throughput inhibitor screening. Protein Expr Purif. 2003 Jan; 27(1):63-74. PMID: 12509986.
      View in: PubMed
    24. Cheng DH, Shen Q, Qian J, Qian Z, Ye QZ. Expression and purification of catalytic domain of human macrophage elastase for high throughput inhibitor screening. Acta Pharmacol Sin. 2002 Feb; 23(2):143-51. PMID: 11866875.
      View in: PubMed
    25. Cheng DH, Tang XC. Comparative studies of huperzine A, E2020, and tacrine on behavior and cholinesterase activities. Pharmacol Biochem Behav. 1998 Jun; 60(2):377-86. PMID: 9632220.
      View in: PubMed
    26. Xiong ZQ, Cheng DH, Tang XC. Effects of huperzine A on nucleus basalis magnocellularis lesion-induced spatial working memory deficit. Zhongguo Yao Li Xue Bao. 1998 Mar; 19(2):128-32. PMID: 10374634.
      View in: PubMed
    27. Cheng DH, Ren H, Tang XC. Huperzine A, a novel promising acetylcholinesterase inhibitor. Neuroreport. 1996 Dec 20; 8(1):97-101. PMID: 9051760.
      View in: PubMed
    28. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Scientific Reports. 6.
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