InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPO Box 389
Smithville TX 78957-0389
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tiniakou I, Hsu PF, Lopez-Zepeda LS, Garipler G, Esteva E, Adams NM, Jang G, Soni C, Lau CM, Liu F, Khodadadi-Jamayran A, Rodrick TC, Jones D, Tsirigos A, Ohler U, Bedford MT, Nimer SD, Kaartinen V, Mazzoni EO, Reizis B. Genome-wide screening identifies Trim33 as an essential regulator of dendritic cell differentiation. Sci Immunol. 2024 Apr 12; 9(94):eadi1023. PMID: 38608038.
    2. Li Y, Dobrolecki LE, Sallas C, Zhang X, Kerr TD, Bisht D, Wang Y, Awasthi S, Kaundal B, Wu S, Peng W, Mendillo ML, Lu Y, Jeter CR, Peng G, Liu J, Westin SN, Sood AK, Lewis MT, Das J, Yi SS, Bedford MT, McGrail DJ, Sahni N. PRMT blockade induces defective DNA replication stress response and synergizes with PARP inhibition. Cell Rep Med. 2023 12 19; 4(12):101326. PMID: 38118413; PMCID: PMC10772459.
      Citations:    Fields:    Translation:HumansCells
    3. Wright T, Wang Y, Stratton SA, Sebastian M, Liu B, Johnson DG, Bedford MT. Loss of the methylarginine reader function of SND1 confers resistance to hepatocellular carcinoma. Biochem J. 2023 11 29; 480(22):1805-1816. PMID: 37905668; PMCID: PMC10860161.
      Citations:    Fields:    Translation:Animals
    4. Zhao F, Deng Y, Yang F, Yan Y, Feng F, Peng B, Gao J, Bedford MT, Li H. Molecular Basis for SPINDOC-Spindlin1 Engagement and Its Role in Transcriptional Attenuation. J Mol Biol. 2024 Apr 01; 436(7):168371. PMID: 37977297.
      Citations: 1     Fields:    Translation:HumansCells
    5. Santos M, Hwang JW, Bedford MT. CARM1 arginine methyltransferase as a therapeutic target for cancer. J Biol Chem. 2023 09; 299(9):105124. PMID: 37536629; PMCID: PMC10474102.
      Citations:    Fields:    Translation:HumansAnimals
    6. Wang Y, Bedford MT. Effectors and effects of arginine methylation. Biochem Soc Trans. 2023 04 26; 51(2):725-734. PMID: 37013969; PMCID: PMC10212539.
      Citations:    Fields:    Translation:Cells
    7. Yin S, Liu L, Ball LE, Wang Y, Bedford MT, Duncan SA, Wang H, Gan W. CDK5-PRMT1-WDR24 signaling cascade promotes mTORC1 signaling and tumor growth. Cell Rep. 2023 04 25; 42(4):112316. PMID: 36995937; PMCID: PMC10539482.
      Citations: 1     Fields:    Translation:Humans
    8. Gao G, Hausmann S, Flores NM, Benitez AM, Shen J, Yang X, Person MD, Gayatri S, Cheng D, Lu Y, Liu B, Mazur PK, Bedford MT. The NFIB/CARM1 partnership is a driver in preclinical models of small cell lung cancer. Nat Commun. 2023 01 23; 14(1):363. PMID: 36690626; PMCID: PMC9870865.
      Citations: 1     Fields:    Translation:AnimalsCells
    9. Horton JR, Zhou J, Chen Q, Zhang X, Bedford MT, Cheng X. A complete methyl-lysine binding aromatic cage constructed by two domains of PHF2. J Biol Chem. 2023 02; 299(2):102862. PMID: 36596360; PMCID: PMC9898751.
      Citations: 1     Fields:    Translation:Cells
    10. Liu Y, Iqbal A, Li W, Ni Z, Wang Y, Ramprasad J, Abraham KJ, Zhang M, Zhao DY, Qin S, Loppnau P, Jiang H, Guo X, Brown PJ, Zhen X, Xu G, Mekhail K, Ji X, Bedford MT, Greenblatt JF, Min J. A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II. Nat Commun. 2022 09 16; 13(1):5453. PMID: 36114190; PMCID: PMC9481570.
    11. Chopra A, Shapira G, Bedford MT, Fry CJ, Shomron N, Biggar K, Admoni-Elisha L, Elbaz T, Feldman M, Levy D. TWIST1 methylation by SETD6 selectively antagonizes LINC-PINT expression in glioma. Nucleic Acids Res. 2022 07 08; 50(12):6903-6918. PMID: 35694846; PMCID: PMC9262621.
      Citations:    Fields:    
    12. Iannelli G, Milite C, Feoli A, Rescigno D, Wang Y, Cipriano A, Viviano M, Bedford MT, Castellano S, Sbardella G, Marechal N, Cura V, Bonnefond L, Troffer-Charlier N, Cavarelli J. Turning Nonselective Inhibitors of Type I Protein Arginine Methyltransferases into Potent and Selective Inhibitors of Protein Arginine Methyltransferase 4 through a Deconstruction-Reconstruction and Fragment-Growing Approach. J Med Chem. 2022 09 08; 65(17):11574-11606. PMID: 35482954; PMCID: PMC9469100.
      Citations:    Fields:    
    13. Fedoriw A, Shi L, O'Brien S, Smitheman KN, Wang Y, Hou J, Sherk C, Rajapurkar S, Laraio J, Williams LJ, Xu C, Han G, Feng Q, Bedford MT, Wang L, Barbash O, Kruger RG, Hwu P, Mohammad HP, Peng W. Inhibiting Type I Arginine Methyltransferase Activity Promotes T Cell-Mediated Antitumor Immune Responses. Cancer Immunol Res. 2022 04 01; 10(4):420-436. PMID: 35181787; PMCID: PMC8976792.
      Citations: 1     Fields:    Translation:HumansAnimals
    14. Van HT, Harkins PR, Patel A, Jain AK, Lu Y, Bedford MT, Santos MA. Methyl-lysine readers PHF20 and PHF20L1 define two distinct?gene expression-regulating NSL complexes. J Biol Chem. 2022 03; 298(3):101588. PMID: 35033534; PMCID: PMC8867114.
      Citations:    Fields:    Translation:Cells
    15. Martinez-Pastor B, Silveira GG, Clarke TL, Chung D, Gu Y, Cosentino C, Davidow LS, Mata G, Hassanieh S, Salsman J, Ciccia A, Bae N, Bedford MT, Megias D, Rubin LL, Efeyan A, Dellaire G, Mostoslavsky R. Assessing kinetics and recruitment of DNA repair factors using high content screens. Cell Rep. 2021 12 28; 37(13):110176. PMID: 34965416; PMCID: PMC8763642.
      Citations: 1     Fields:    Translation:HumansCells
    16. Yu D, Horton JR, Yang J, Hajian T, Vedadi M, Sagum CA, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions. Nucleic Acids Res. 2021 11 18; 49(20):11629-11642. PMID: 34086966; PMCID: PMC8599731.
      Citations: 6     Fields:    Translation:HumansCells
    17. Yang F, Chen J, Liu B, Gao G, Sebastian M, Jeter C, Shen J, Person MD, Bedford MT. SPINDOC binds PARP1 to facilitate PARylation. Nat Commun. 2021 11 04; 12(1):6362. PMID: 34737271; PMCID: PMC8568969.
      Citations:    Fields:    Translation:HumansAnimalsCells
    18. Suh JL, Bsteh D, Hart B, Si Y, Weaver TM, Pribitzer C, Lau R, Soni S, Ogana H, Rectenwald JM, Norris JL, Cholensky SH, Sagum C, Umana JD, Li D, Hardy B, Bedford MT, Mumenthaler SM, Lenz HJ, Kim YM, Wang GG, Pearce KH, James LI, Kireev DB, Musselman CA, Frye SV, Bell O. Reprogramming CBX8-PRC1 function with a positive allosteric modulator. Cell Chem Biol. 2022 04 21; 29(4):555-571.e11. PMID: 34715055; PMCID: PMC9035045.
      Citations: 2     Fields:    Translation:HumansCells
    19. Maron MI, Lehman SM, Gayatri S, DeAngelo JD, Hegde S, Lorton BM, Sun Y, Bai DL, Sidoli S, Gupta V, Marunde MR, Bone JR, Sun ZW, Bedford MT, Shabanowitz J, Chen H, Hunt DF, Shechter D. Independent transcriptomic and proteomic regulation by type I and II protein arginine methyltransferases. iScience. 2021 Sep 24; 24(9):102971. PMID: 34505004; PMCID: PMC8417332.
      Citations: 1     
    20. Shepley-McTaggart A, Sagum CA, Oliva I, Rybakovsky E, DiGuilio K, Liang J, Bedford MT, Cassel J, Sudol M, Mullin JM, Harty RN. SARS-CoV-2 Envelope (E) protein interacts with PDZ-domain-2 of host tight junction protein ZO1. PLoS One. 2021; 16(6):e0251955. PMID: 34106957; PMCID: PMC8189464.
      Citations: 17     Fields:    Translation:HumansCells
    21. Wang Y, Person MD, Bedford MT. Pan-methylarginine antibody generation using PEG linked GAR motifs as antigens. Methods. 2022 04; 200:80-86. PMID: 34107353; PMCID: PMC8645660.
      Citations:    Fields:    Translation:AnimalsCells
    22. Chen J, Horton J, Sagum C, Zhou J, Cheng X, Bedford MT. Histone H3 N-terminal mimicry drives a novel network of methyl-effector interactions. Biochem J. 2021 05 28; 478(10):1943-1958. PMID: 33969871; PMCID: PMC8166343.
      Citations:    Fields:    Translation:HumansCells
    23. Shepley-McTaggart A, Schwoerer MP, Sagum CA, Bedford MT, Jaladanki CK, Fan H, Cassel J, Harty RN. Ubiquitin Ligase SMURF2 Interacts with Filovirus VP40 and Promotes Egress of VP40 VLPs. Viruses. 2021 02 12; 13(2). PMID: 33673144; PMCID: PMC7918931.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    24. Liang J, Ruthel G, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Jaladanki CK, Fan H, Freedman BD, Harty RN. Angiomotin Counteracts the Negative Regulatory Effect of Host WWOX on Viral PPxY-Mediated Egress. J Virol. 2021 03 25; 95(8). PMID: 33536174; PMCID: PMC8103691.
      Citations: 1     Fields:    
    25. Genois MM, Yasuhara T, Jackson J, Saxena S, Ahel I, Bedford MT, Vindigni A, Zou L, Gagn? JP, Langelier MF, Pascal JM, Poirier GG. CARM1 regulates replication fork speed and stress response by stimulating PARP1. Mol Cell. 2021 02 18; 81(4):784-800.e8. PMID: 33412112; PMCID: PMC7897296.
      Citations: 17     Fields:    Translation:HumansCells
    26. Wright T, Wang Y, Bedford MT. The Role of the PRMT5-SND1 Axis in Hepatocellular Carcinoma. Epigenomes. 2021 Mar; 5(1). PMID: 33768972; PMCID: PMC7990390.
      Citations: 4     
    27. Shepley-McTaggart A, Sagum CA, Oliva I, Rybakovsky E, DiGuilio K, Liang J, Bedford MT, Cassel J, Sudol M, Mullin JM, Harty RN. SARS-CoV-2 Envelope (E) Protein Interacts with PDZ-Domain-2 of Host Tight Junction Protein ZO1. bioRxiv. 2020 Dec 23. PMID: 33398268; PMCID: PMC7781303.
      Citations: 1     
    28. Baumert R, Ji H, Paulucci-Holthauzen A, Wolfe A, Sagum C, Hodgson L, Arikkath J, Chen X, Bedford MT, Waxham MN, McCrea PD. Novel phospho-switch function of delta-catenin in dendrite development. J Cell Biol. 2020 11 02; 219(11). PMID: 33007084; PMCID: PMC7534926.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    29. Tetenborg S, Wang HY, Nemitz L, Depping A, Espejo AB, Aseervatham J, Bedford MT, Janssen-Bienhold U, O'Brien J, Dedek K. Phosphorylation of Connexin36 near the C-terminus switches binding affinities for PDZ-domain and 14-3-3 proteins in vitro. Sci Rep. 2020 10 27; 10(1):18378. PMID: 33110101; PMCID: PMC7592057.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Vaughan RM, Kupai A, Foley CA, Sagum CA, Tibben BM, Eden HE, Tiedemann RL, Berryhill CA, Patel V, Shaw KM, Krajewski K, Strahl BD, Bedford MT, Frye SV, Dickson BM, Rothbart SB. The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells. Epigenetics Chromatin. 2020 10 23; 13(1):44. PMID: 33097091; PMCID: PMC7585203.
      Citations: 3     Fields:    Translation:HumansCells
    31. Woodcock CB, Horton JR, Zhou J, Bedford MT, Blumenthal RM, Zhang X, Cheng X. Biochemical and structural basis for YTH domain of human YTHDC1 binding to methylated adenine in DNA. Nucleic Acids Res. 2020 10 09; 48(18):10329-10341. PMID: 32663306; PMCID: PMC7544203.
      Citations: 9     Fields:    Translation:HumansCells
    32. Cheng D, Gao G, Di Lorenzo A, Jayne S, Hottiger MO, Bedford MT, Richard S. Genetic evidence for partial redundancy between the arginine methyltransferases CARM1 and PRMT6. J Biol Chem. 2020 12 11; 295(50):17060-17070. PMID: 33008887; PMCID: PMC7863876.
      Citations: 7     Fields:    Translation:AnimalsCells
    33. Shen Y, Gao G, Yu X, Kim H, Wang L, Xie L, Schwarz M, Chen X, Guccione E, Liu J, Bedford MT, Jin J. Discovery of First-in-Class Protein Arginine Methyltransferase 5 (PRMT5) Degraders. J Med Chem. 2020 09 10; 63(17):9977-9989. PMID: 32787082; PMCID: PMC7486226.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    34. Hwang JW, Kim SN, Myung N, Song D, Han G, Bae GU, Bedford MT, Kim YK. PRMT5 promotes DNA repair through methylation of 53BP1 and is regulated by Src-mediated phosphorylation. Commun Biol. 2020 08 05; 3(1):428. PMID: 32759981; PMCID: PMC7406651.
      Citations: 9     Translation:HumansCells
    35. Prasanth KR, Hirano M, Fagg WS, McAnarney ET, Shan C, Xie X, Hage A, Pietzsch CA, Bukreyev A, Rajsbaum R, Shi PY, Bedford MT, Bradrick SS, Menachery V, Garcia-Blanco MA. Topoisomerase III-? is required for efficient replication of positive-sense RNA viruses. Antiviral Res. 2020 10; 182:104874. PMID: 32735900; PMCID: PMC7386308.
      Citations: 9     Fields:    Translation:HumansCells
    36. Veazey KJ, Cheng D, Lin K, Villarreal OD, Gao G, Perez-Oquendo M, Van HT, Stratton SA, Green M, Xu H, Lu Y, Bedford MT, Santos MA. CARM1 inhibition reduces histone acetyltransferase activity causing synthetic lethality in CREBBP/EP300-mutated lymphomas. Leukemia. 2020 12; 34(12):3269-3285. PMID: 32576962; PMCID: PMC7688486.
      Citations: 6     Fields:    Translation:AnimalsCells
    37. Prasanth KR, Hirano M, Fagg WS, McAnarney ET, Shan C, Xie X, Hage A, Pietzsch CA, Bukreyev A, Rajsbaum R, Shi PY, Bedford MT, Bradrick SS, Menachery V, Garcia-Blanco MA. Topoisomerase III-? is required for efficient replication of positive-sense RNA viruses. bioRxiv. 2020 Mar 27. PMID: 32511318; PMCID: PMC7239047.
    38. Stossi F, Dandekar RD, Mancini MG, Gu G, Fuqua SAW, Nardone A, De Angelis C, Fu X, Schiff R, Xu W, Mancini MA, Bedford MT, Johansson HE, Stephan CC. Estrogen-induced transcription at individual alleles is independent of receptor level and active conformation but can be modulated by coactivators activity. Nucleic Acids Res. 2020 02 28; 48(4):1800-1810. PMID: 31930333; PMCID: PMC7039002.
      Citations: 6     Fields:    Translation:HumansCells
    39. He W, Zhang L, Villarreal OD, Fu R, Bedford E, Dou J, Patel AY, Bedford MT, Shi X, Chen T, Bartholomew B, Xu H. Author Correction: De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens. Nat Commun. 2020 Feb 25; 11(1):1134. PMID: 32098955; PMCID: PMC7042308.
      Citations:    Fields:    
    40. Jain K, Fraser CS, Marunde MR, Parker MM, Sagum C, Burg JM, Hall N, Popova IK, Rodriguez KL, Vaidya A, Krajewski K, Keogh MC, Bedford MT, Strahl BD. Characterization of the plant homeodomain (PHD) reader family for their histone tail interactions. Epigenetics Chromatin. 2020 01 24; 13(1):3. PMID: 31980037; PMCID: PMC6979384.
      Citations: 17     Fields:    Translation:HumansCells
    41. Han Z, Dash S, Sagum CA, Ruthel G, Jaladanki CK, Berry CT, Schwoerer MP, Harty NM, Freedman BD, Bedford MT, Fan H, Sidhu SS, Sudol M, Shtanko O, Harty RN. Modular mimicry and engagement of the Hippo pathway by Marburg virus VP40: Implications for filovirus biology and budding. PLoS Pathog. 2020 01; 16(1):e1008231. PMID: 31905227; PMCID: PMC6977764.
      Citations: 6     Fields:    Translation:HumansCells
    42. Wu X, Liu S, Sagum C, Chen J, Singh R, Chaturvedi A, Horton JR, Kashyap TR, Fushman D, Cheng X, Bedford MT, Wang B. Crosstalk between Lys63- and Lys11-polyubiquitin signaling at DNA damage sites is driven by Cezanne. Genes Dev. 2019 12 01; 33(23-24):1702-1717. PMID: 31699778; PMCID: PMC6942045.
      Citations: 9     Fields:    Translation:HumansCells
    43. Manickavinayaham S, Biswas AK, Bedford E, Klein BJ, Kutateladze TG, Liu B, Bedford MT, Johnson DG, V?lez-Cruz R. E2F1 acetylation directs p300/CBP-mediated histone acetylation at DNA double-strand breaks to facilitate repair. Nat Commun. 2019 10 30; 10(1):4951. PMID: 31666529; PMCID: PMC6821830.
      Citations: 19     Fields:    Translation:AnimalsCells
    44. Avasarala S, Wu PY, Khan SQ, Yanlin S, Van Scoyk M, Bao J, Di Lorenzo A, David O, Bedford MT, Gupta V, Winn RA, Bikkavilli RK. PRMT6 Promotes Lung Tumor Progression via the Alternate Activation of Tumor-Associated Macrophages. Mol Cancer Res. 2020 01; 18(1):166-178. PMID: 31619507; PMCID: PMC6942249.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    45. He W, Zhang L, Villarreal OD, Fu R, Bedford E, Dou J, Patel AY, Bedford MT, Shi X, Chen T, Bartholomew B, Xu H. De novo identification of essential protein domains from CRISPR-Cas9 tiling-sgRNA knockout screens. Nat Commun. 2019 Oct 04; 10(1):4541. PMID: 31586052; PMCID: PMC6778102.
      Citations: 12     Fields:    Translation:HumansCells
    46. Chen J, Sagum C, Bedford MT. Protein domain microarrays as a platform to decipher signaling pathways and the histone code. Methods. 2020 12 01; 184:4-12. PMID: 31449908.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    47. Lamb KN, Bsteh D, Dishman SN, Moussa HF, Fan H, Stuckey JI, Norris JL, Cholensky SH, Li D, Wang J, Sagum C, Stanton BZ, Bedford MT, Pearce KH, Kenakin TP, Kireev DB, Wang GG, James LI, Bell O, Frye SV. Discovery and Characterization of a Cellular Potent Positive Allosteric Modulator of the Polycomb Repressive Complex 1 Chromodomain, CBX7. Cell Chem Biol. 2019 10 17; 26(10):1365-1379.e22. PMID: 31422906; PMCID: PMC6800648.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    48. Gao G, Zhang L, Villarreal OD, He W, Su D, Bedford E, Moh P, Shen J, Shi X, Bedford MT, Xu H. PRMT1 loss sensitizes cells to PRMT5 inhibition. Nucleic Acids Res. 2019 06 04; 47(10):5038-5048. PMID: 30916320; PMCID: PMC6547413.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    49. Rajendran P, Johnson G, Li L, Chen YS, Dashwood M, Nguyen N, Ulusan A, Ertem F, Zhang M, Li J, Sun D, Huang Y, Wang S, Leung HC, Lieberman D, Beaver L, Ho E, Bedford M, Chang K, Vilar E, Dashwood R. Acetylation of CCAR2 Establishes a BET/BRD9 Acetyl Switch in Response to Combined Deacetylase and Bromodomain Inhibition. Cancer Res. 2019 03 01; 79(5):918-927. PMID: 30643017; PMCID: PMC6397680.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    50. Roth L, Wakim J, Wasserman E, Shalev M, Arman E, Stein M, Brumfeld V, Sagum CA, Bedford MT, Tuckermann J, Elson A. Phosphorylation of the phosphatase PTPROt at Tyr399 is a molecular switch that controls osteoclast activity and bone mass in vivo. Sci Signal. 2019 01 08; 12(563). PMID: 30622194.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    51. Hupalowska A, Jedrusik A, Zhu M, Bedford MT, Glover DM, Zernicka-Goetz M. CARM1 and Paraspeckles Regulate Pre-implantation Mouse Embryo Development. Cell. 2018 12 13; 175(7):1902-1916.e13. PMID: 30550788; PMCID: PMC6292842.
      Citations: 34     Fields:    Translation:Animals
    52. Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV. Correction to "Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID subunit 1". Biochemistry. 2018 12 11; 57(49):6806. PMID: 30485080.
      Citations:    Fields:    
    53. Bao J, Di Lorenzo A, Lin K, Lu Y, Zhong Y, Sebastian MM, Muller WJ, Yang Y, Bedford MT. Mouse Models of Overexpression Reveal Distinct Oncogenic Roles for Different Type I Protein Arginine Methyltransferases. Cancer Res. 2019 01 01; 79(1):21-32. PMID: 30352814; PMCID: PMC6714580.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    54. Cheng D, Vemulapalli V, Lu Y, Shen J, Aoyagi S, Fry CJ, Yang Y, Foulds CE, Stossi F, Mancini MA, O'Malley BW, Walker CL, Boyer TG, Bedford MT, Trevi?o LS. CARM1 methylates MED12 to regulate its RNA-binding ability. Life Sci Alliance. 2018 Oct; 1(5):e201800117. PMID: 30456381; PMCID: PMC6238599.
      Citations: 19     Fields:    
    55. Bedford MT. Screening for histone codebreakers. J Biol Chem. 2018 08 31; 293(35):13766-13767. PMID: 30171150; PMCID: PMC6120206.
      Citations:    Fields:    Translation:HumansCells
    56. Bao J, Perez CJ, Kim J, Zhang H, Murphy CJ, Hamidi T, Platt CD, Chou J, Deng M, Zhou MH, Huang Y, Lin K, Lu Y, Chen T, Bedford MT, Dent SY, Richburg JH, Pan HL, Geha RS, Shi Q, Benavides F, Jaubert J, Gait?n-Pe?as H, Gu?net JL, Est?vez R. Deficient LRRC8A-dependent volume-regulated anion channel activity is associated with male infertility in mice. JCI Insight. 2018 08 23; 3(16). PMID: 30135305; PMCID: PMC6141173.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    57. Han Z, Schwoerer MP, Hicks P, Liang J, Ruthel G, Berry CT, Freedman BD, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN. Host Protein BAG3 is a Negative Regulator of Lassa VLP Egress. Diseases. 2018 Jul 13; 6(3). PMID: 30011814; PMCID: PMC6163595.
      Citations: 6     
    58. Hamidi T, Singh AK, Veland N, Vemulapalli V, Chen J, Hardikar S, Bao J, Fry CJ, Yang V, Lee KA, Guo A, Arrowsmith CH, Bedford MT, Chen T. Identification of Rpl29 as a major substrate of the lysine methyltransferase Set7/9. J Biol Chem. 2018 08 17; 293(33):12770-12780. PMID: 29959229; PMCID: PMC6102145.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    59. Bao J, Shen J, Lin K, Lu Y, Bedford MT, Rousseaux S. The arginine methyltransferase CARM1 represses p300?ACT?CREMt activity and is required for spermiogenesis. Nucleic Acids Res. 2018 05 18; 46(9):4327-4343. PMID: 29659998; PMCID: PMC5961101.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    60. Suh JL, Watts B, Stuckey JI, Norris-Drouin JL, Cholensky SH, Dickson BM, An Y, Mathea S, Salah E, Knapp S, Khan A, Adams AT, Strahl BD, Sagum CA, Bedford MT, James LI, Kireev DB, Frye SV. Quantitative Characterization of Bivalent Probes for a Dual Bromodomain Protein, Transcription Initiation Factor TFIID Subunit 1. Biochemistry. 2018 04 10; 57(14):2140-2149. PMID: 29558110; PMCID: PMC5937704.
      Citations: 4     Fields:    Translation:Humans
    61. Xi Y, Shi J, Li W, Tanaka K, Allton KL, Richardson D, Li J, Franco HL, Nagari A, Malladi VS, Coletta LD, Simper MS, Keyomarsi K, Shen J, Bedford MT, Shi X, Barton MC, Kraus WL, Li W, Dent SYR. Histone modification profiling in breast cancer cell lines highlights commonalities and differences among subtypes. BMC Genomics. 2018 02 20; 19(1):150. PMID: 29458327; PMCID: PMC5819162.
      Citations: 25     Fields:    Translation:HumansCells
    62. Franco HL, Nagari A, Malladi VS, Li W, Xi Y, Richardson D, Allton KL, Tanaka K, Li J, Murakami S, Keyomarsi K, Bedford MT, Shi X, Li W, Barton MC, Dent SYR, Kraus WL. Enhancer transcription reveals subtype-specific gene expression programs controlling breast cancer pathogenesis. Genome Res. 2018 02; 28(2):159-170. PMID: 29273624; PMCID: PMC5793780.
      Citations: 61     Fields:    Translation:HumansCells
    63. Veland N, Hardikar S, Zhong Y, Gayatri S, Dan J, Strahl BD, Rothbart SB, Bedford MT, Chen T. The Arginine Methyltransferase PRMT6 Regulates DNA Methylation and Contributes to Global DNA Hypomethylation in Cancer. Cell Rep. 2017 Dec 19; 21(12):3390-3397. PMID: 29262320; PMCID: PMC5753604.
      Citations: 31     Fields:    Translation:HumansCells
    64. Bae N, Gao M, Li X, Premkumar T, Chen J, Bedford MT, Sbardella G. A transcriptional coregulator, SPIN?DOC, attenuates the coactivator activity of Spindlin1. J Biol Chem. 2017 12 22; 292(51):20808-20817. PMID: 29061846; PMCID: PMC5743059.
      Citations: 10     Fields:    Translation:HumansCells
    65. Han Z, Sagum CA, Takizawa F, Ruthel G, Berry CT, Kong J, Sunyer JO, Freedman BD, Bedford MT, Sidhu SS, Sudol M, Harty RN. Ubiquitin Ligase WWP1 Interacts with Ebola Virus VP40 To Regulate Egress. J Virol. 2017 10 15; 91(20). PMID: 28768865; PMCID: PMC5625505.
      Citations: 22     Fields:    Translation:HumansCells
    66. Carr SM, Munro S, Sagum CA, Fedorov O, Bedford MT, La Thangue NB. Tudor-domain protein PHF20L1 reads lysine methylated retinoblastoma tumour suppressor protein. Cell Death Differ. 2017 12; 24(12):2139-2149. PMID: 28841214; PMCID: PMC5686351.
      Citations: 9     Fields:    Translation:HumansCells
    67. Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN. Correction: Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS Pathog. 2017 Jul; 13(7):e1006519. PMID: 28723972; PMCID: PMC5517035.
      Citations: 1     Fields:    
    68. Gates LA, Shi J, Rohira AD, Feng Q, Zhu B, Bedford MT, Sagum CA, Jung SY, Qin J, Tsai MJ, Tsai SY, Li W, Foulds CE, O'Malley BW. Acetylation on histone H3 lysine 9 mediates a switch from transcription initiation to elongation. J Biol Chem. 2017 09 01; 292(35):14456-14472. PMID: 28717009; PMCID: PMC5582839.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    69. Bae N, Su X, Lv J, Cheng D, Sagum C, Bai X, Johnson C, Khalil MI, Shen J, Chen K, Li H, Bedford MT, Viviano M, Castellano S, Sbardella G. Developing Spindlin1 small-molecule inhibitors by using protein microarrays. Nat Chem Biol. 2017 Jul; 13(7):750-756. PMID: 28504676; PMCID: PMC5831360.
      Citations: 13     Fields:    Translation:HumansCells
    70. Gao G, Dhar S, Bedford MT. PRMT5 regulates IRES-dependent translation via methylation of hnRNP A1. Nucleic Acids Res. 2017 05 05; 45(8):4359-4369. PMID: 28115626; PMCID: PMC5416833.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    71. Shanle EK, Shinsky SA, Bridgers JB, Bae N, Sagum C, Krajewski K, Rothbart SB, Bedford MT, Strahl BD. Histone peptide microarray screen of chromo and Tudor domains defines new histone lysine methylation interactions. Epigenetics Chromatin. 2017; 10:12. PMID: 28293301; PMCID: PMC5348760.
      Citations: 19     Fields:    Translation:HumansCells
    72. Liang J, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Han Z, Harty RN. Chaperone-Mediated Autophagy Protein BAG3 Negatively Regulates Ebola and Marburg VP40-Mediated Egress. PLoS Pathog. 2017 01; 13(1):e1006132. PMID: 28076420; PMCID: PMC5226679.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    73. Espejo AB, Gao G, Black K, Gayatri S, Veland N, Kim J, Chen T, Sudol M, Walker C, Bedford MT. PRMT5 C-terminal Phosphorylation Modulates a 14-3-3/PDZ Interaction Switch. J Biol Chem. 2017 02 10; 292(6):2255-2265. PMID: 28031468; PMCID: PMC5313098.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    74. Norrie JL, Li Q, Co S, Huang BL, Ding D, Uy JC, Ji Z, Mackem S, Galli A, Ji H, Vokes SA, Bedford MT. PRMT5 is essential for the maintenance of chondrogenic progenitor cells in the limb bud. Development. 2016 12 15; 143(24):4608-4619. PMID: 27827819; PMCID: PMC5201029.
      Citations: 11     Fields:    Translation:AnimalsCells
    75. Barnea M, Olender T, Bedford MT, Elson A. Regulation of receptor-type protein tyrosine phosphatases by their C-terminal tail domains. Biochem Soc Trans. 2016 10 15; 44(5):1295-1303. PMID: 27911712.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    76. Han Z, Sagum CA, Bedford MT, Sidhu SS, Sudol M, Harty RN. ITCH E3 Ubiquitin Ligase Interacts with Ebola Virus VP40 To Regulate Budding. J Virol. 2016 10 15; 90(20):9163-71. PMID: 27489272; PMCID: PMC5044852.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    77. Tsai WC, Gayatri S, Reineke LC, Bedford MT, Lloyd RE, Sbardella G. Arginine Demethylation of G3BP1 Promotes Stress Granule Assembly. J Biol Chem. 2016 Oct 21; 291(43):22671-22685. PMID: 27601476; PMCID: PMC5077203.
      Citations: 77     Fields:    Translation:HumansCells
    78. Park IY, Powell RT, Tripathi DN, Dere R, Ho TH, Blasius TL, Chiang YC, Davis IJ, Fahey CC, Hacker KE, Verhey KJ, Bedford MT, Jonasch E, Rathmell WK, Walker CL. Dual Chromatin and Cytoskeletal Remodeling by SETD2. Cell. 2016 Aug 11; 166(4):950-962. PMID: 27518565; PMCID: PMC5101839.
      Citations: 86     Fields:    Translation:HumansCells
    79. Gayatri S, Cowles MW, Vemulapalli V, Cheng D, Sun ZW, Bedford MT. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Sci Rep. 2016 06 24; 6:28718. PMID: 27338245; PMCID: PMC4919620.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    80. Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv. 2016 04; 2(4):e1501290. PMID: 27757426; PMCID: PMC5065225.
      Citations: 15     Fields:    Translation:HumansCells
    81. Zhang X, Peng D, Xi Y, Yuan C, Sagum CA, Klein BJ, Tanaka K, Wen H, Kutateladze TG, Li W, Bedford MT, Shi X. G9a-mediated methylation of ERa links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nat Commun. 2016 Mar 10; 7:10810. PMID: 26960573; PMCID: PMC4792926.
      Citations: 28     Fields:    Translation:HumansCells
    82. Bao J, Bedford MT. Epigenetic regulation of the histone-to-protamine transition during spermiogenesis. Reproduction. 2016 May; 151(5):R55-70. PMID: 26850883; PMCID: PMC4896072.
      Citations: 70     Fields:    Translation:HumansAnimals
    83. Stuckey JI, Dickson BM, Cheng N, Liu Y, Norris JL, Cholensky SH, Tempel W, Qin S, Huber KG, Sagum C, Black K, Li F, Huang XP, Roth BL, Baughman BM, Senisterra G, Pattenden SG, Vedadi M, Brown PJ, Bedford MT, Min J, Arrowsmith CH, James LI, Frye SV. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nat Chem Biol. 2016 Mar; 12(3):180-7. PMID: 26807715; PMCID: PMC4755828.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    84. von Maessenhausen A, Espejo A, Schleicher M, Perner S, Bedford MT, Flaig R, Metzger E, Willmann D, McMillan J, Forne I, Metzger P, Gerhardt S, Petroll K, Urban S, Schott AK, Eberlin A, Wohlwend D, Sch?le KM, Jung M, Dengjel J, Imhof A, Einsle O, Sch?le R. Assembly of methylated KDM1A and CHD1 drives androgen receptor-dependent transcription and translocation. Nat Struct Mol Biol. 2016 Feb; 23(2):132-9. PMID: 26751641.
      Citations: 28     Fields:    Translation:HumansCells
    85. Bedford MT, Sarker RS, John-Schuster G, Bohla A, Mutze K, Burgstaller G, K?nigshoff M, Eickelberg O, Yildirim A?. Coactivator-Associated Arginine Methyltransferase-1 Function in Alveolar Epithelial Senescence and Elastase-Induced Emphysema Susceptibility. Am J Respir Cell Mol Biol. 2015 Dec; 53(6):769-81. PMID: 25906418; PMCID: PMC5455466.
      Citations: 8     Fields:    Translation:AnimalsCells
    86. Zhang G, Ponnaluri VK, Deepti K, Chin HG, Dai N, Sagum C, Black K, Bedford MT, Cheng X, Pradhan S, Est?ve PO, Corr?a IR. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Res. 2016 Feb 29; 44(4):1642-56. PMID: 26553800; PMCID: PMC4770214.
      Citations: 4     Fields:    Translation:AnimalsCells
    87. Perez CJ, Mecklenburg L, Iritani BM, Espejo A, Napoli E, Song G, DiGiovanni J, Giulivi C, Bedford MT, Dent SYR, Wood RD, Kusewitt DF, Benavides F, Jaubert J, Martinez-Santamaria L, Del R?o M, Gu?net JL, Conti CJ. Increased Susceptibility to Skin Carcinogenesis Associated with a Spontaneous Mouse Mutation in the Palmitoyl Transferase Zdhhc13 Gene. J Invest Dermatol. 2015 Dec; 135(12):3133-3143. PMID: 26288350; PMCID: PMC4898190.
      Citations: 14     Fields:    Translation:AnimalsCells
    88. Hadjikyriacou A, Yang Y, Espejo A, Bedford MT, Clarke SG. Unique Features of Human Protein Arginine Methyltransferase 9 (PRMT9) and Its Substrate RNA Splicing Factor SF3B2. J Biol Chem. 2015 Jul 03; 290(27):16723-43. PMID: 25979344; PMCID: PMC4505422.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    89. Kapoor P, Bao Y, Xiao J, Espejo A, Yang L, Bedford MT, Peng G, Shen X. Phosphorylation-Dependent Enhancement of Rad53 Kinase Activity through the INO80 Chromatin Remodeling Complex. Mol Cell. 2015 Jun 04; 58(5):863-9. PMID: 25959398; PMCID: PMC4485934.
      Citations: 5     Fields:    Translation:AnimalsCells
    90. Hu SB, Xiang JF, Li X, Xu Y, Xue W, Huang M, Wong CC, Sagum CA, Bedford MT, Yang L, Cheng D, Chen LL. Protein arginine methyltransferase CARM1 attenuates the paraspeckle-mediated nuclear retention of mRNAs containing IRAlus. Genes Dev. 2015 Mar 15; 29(6):630-45. PMID: 25792598; PMCID: PMC4378195.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    91. Yang Y, Hadjikyriacou A, Xia Z, Gayatri S, Kim D, Zurita-Lopez C, Kelly R, Guo A, Li W, Clarke SG, Bedford MT. PRMT9 is a type II methyltransferase that methylates the splicing factor SAP145. Nat Commun. 2015 Mar 04; 6:6428. PMID: 25737013; PMCID: PMC4351962.
      Citations: 78     Fields:    Translation:HumansCells
    92. Levy-Apter E, Finkelshtein E, Vemulapalli V, Li SS, Bedford MT, Elson A. Adaptor protein GRB2 promotes Src tyrosine kinase activation and podosomal organization by protein-tyrosine phosphatase ? in osteoclasts. J Biol Chem. 2014 Dec 26; 289(52):36048-58. PMID: 25381250; PMCID: PMC4276870.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    93. Carr SM, Munro S, Zalmas LP, Fedorov O, Johansson C, Krojer T, Sagum CA, Bedford MT, Oppermann U, La Thangue NB. Lysine methylation-dependent binding of 53BP1 to the pRb tumor suppressor. Proc Natl Acad Sci U S A. 2014 Aug 05; 111(31):11341-6. PMID: 25049398; PMCID: PMC4128150.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    94. Di Lorenzo A, Yang Y, Macaluso M, Bedford MT. A gain-of-function mouse model identifies PRMT6 as a NF-?B coactivator. Nucleic Acids Res. 2014 Jul; 42(13):8297-309. PMID: 24939901; PMCID: PMC4117762.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    95. Gayatri S, Bedford MT. Readers of histone methylarginine marks. Biochim Biophys Acta. 2014 Aug; 1839(8):702-10. PMID: 24583552; PMCID: PMC4099268.
      Citations: 55     Fields:    Translation:HumansCells
    96. Yang Y, McBride KM, Hensley S, Lu Y, Chedin F, Bedford MT. Arginine methylation facilitates the recruitment of TOP3B to chromatin to prevent R loop accumulation. Mol Cell. 2014 Feb 06; 53(3):484-97. PMID: 24507716; PMCID: PMC3959860.
      Citations: 115     Fields:    Translation:HumansAnimalsCells
    97. Terragni J, Deepti K, Chin HG, Dai N, Espejo A, Bedford MT, Pradhan S, Est?ve PO, Corr?a IR. Methyllysine reader plant homeodomain (PHD) finger protein 20-like 1 (PHF20L1) antagonizes DNA (cytosine-5) methyltransferase 1 (DNMT1) proteasomal degradation. J Biol Chem. 2014 Mar 21; 289(12):8277-87. PMID: 24492612; PMCID: PMC3961655.
      Citations: 19     Fields:    Translation:HumansCells
    98. Synofzik M, Lee J, Sagum CA, Mahajnah M, Sharkia R, Drouot N, Renaud M, Klein FA, Anheim M, Tranchant C, Mignot C, Mandel JL, Bedford M, Bauer P, Salih MA, Aldaz CM, Koenig M, Mallaret M, Sch?le R, Sch?ls L. The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain. 2014 Feb; 137(Pt 2):411-9. PMID: 24369382; PMCID: PMC3914474.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    99. Feng Y, Maity R, Whitelegge JP, Hadjikyriacou A, Li Z, Zurita-Lopez C, Al-Hadid Q, Clark AT, Bedford MT, Masson JY, Clarke SG. Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. J Biol Chem. 2013 Dec 27; 288(52):37010-25. PMID: 24247247; PMCID: PMC3873558.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    100. Guo A, Gu H, Zhou J, Mulhern D, Wang Y, Lee KA, Yang V, Aguiar M, Kornhauser J, Jia X, Ren J, Beausoleil SA, Silva JC, Vemulapalli V, Bedford MT, Comb MJ. Immunoaffinity enrichment and mass spectrometry analysis of protein methylation. Mol Cell Proteomics. 2014 Jan; 13(1):372-87. PMID: 24129315; PMCID: PMC3879628.
      Citations: 178     Fields:    Translation:HumansAnimalsCells
    101. Moehlenbrink J, Lu YC, Zalmas LP, Sagum CA, Carr S, McGouran JF, Alexander L, Fedorov O, Munro S, Kessler B, Bedford MT, Yu Q, La Thangue NB, Zheng S. Arginine methylation-dependent reader-writer interplay governs growth control by E2F-1. Mol Cell. 2013 Oct 10; 52(1):37-51. PMID: 24076217; PMCID: PMC4129656.
      Citations: 70     Fields:    Translation:HumansCells
    102. Zeng H, Wu J, Bedford MT, Sbardella G, Hoffmann FM, Bi K, Xu W. A TR-FRET-based functional assay for screening activators of CARM1. Chembiochem. 2013 May 10; 14(7):827-35. PMID: 23585185; PMCID: PMC3828750.
      Citations: 7     Fields:    Translation:HumansCells
    103. James LI, Barsyte-Lovejoy D, Zhong N, Krichevsky L, Korboukh VK, Herold JM, MacNevin CJ, Norris JL, Sagum CA, Tempel W, Marcon E, Guo H, Gao C, Huang XP, Duan S, Emili A, Greenblatt JF, Kireev DB, Jin J, Janzen WP, Brown PJ, Bedford MT, Arrowsmith CH, Frye SV. Discovery of a chemical probe for the L3MBTL3 methyllysine reader domain. Nat Chem Biol. 2013 Mar; 9(3):184-91. PMID: 23292653; PMCID: PMC3577944.
      Citations: 70     Fields:    Translation:HumansCells
    104. Dhar S, Vemulapalli V, Patananan AN, Huang GL, Di Lorenzo A, Richard S, Comb MJ, Guo A, Clarke SG, Bedford MT. Loss of the major Type I arginine methyltransferase PRMT1 causes substrate scavenging by other PRMTs. Sci Rep. 2013; 3:1311. PMID: 23419748; PMCID: PMC3575585.
      Citations: 83     Fields:    Translation:HumansCells
    105. Li J, Zhao Z, Carter C, Ehrlich LI, Bedford MT, Richie ER. Coactivator-associated arginine methyltransferase 1 regulates fetal hematopoiesis and thymocyte development. J Immunol. 2013 Jan 15; 190(2):597-604. PMID: 23248263; PMCID: PMC3538901.
      Citations: 7     Fields:    Translation:AnimalsCells
    106. Yang Y, Bedford MT. Protein arginine methyltransferases and cancer. Nat Rev Cancer. 2013 Jan; 13(1):37-50. PMID: 23235912.
      Citations: 411     Fields:    Translation:HumansAnimalsCells
    107. Yang Y, Bedford MT. Titivated for destruction: the methyl degron. Mol Cell. 2012 Nov 30; 48(4):487-8. PMID: 23200121; PMCID: PMC3563253.
      Citations: 6     Fields:    
    108. Spannhoff A, Milite C, Dal Piaz F, Cheng D, Tosco A, Viviano M, Yamani A, Cianciulli A, Sala M, Cura V, Cavarelli J, Novellino E, Mai A, Bedford MT, Sbardella G, Castellano S. Identification of small-molecule enhancers of arginine methylation catalyzed by coactivator-associated arginine methyltransferase 1. J Med Chem. 2012 Nov 26; 55(22):9875-90. PMID: 23095008; PMCID: PMC3508294.
      Citations: 5     Fields:    Translation:HumansCells
    109. Rothbart SB, Krajewski K, Nady N, Tempel W, Xue S, Badeaux AI, Barsyte-Lovejoy D, Martinez JY, Bedford MT, Fuchs SM, Arrowsmith CH, Strahl BD. Association of UHRF1 with methylated H3K9 directs the maintenance of DNA methylation. Nat Struct Mol Biol. 2012 Nov; 19(11):1155-60. PMID: 23022729; PMCID: PMC3492551.
      Citations: 167     Fields:    Translation:HumansCells
    110. Cui G, Park S, Badeaux AI, Kim D, Lee J, Thompson JR, Yan F, Kaneko S, Yuan Z, Botuyan MV, Bedford MT, Cheng JQ, Mer G. PHF20 is an effector protein of p53 double lysine methylation that stabilizes and activates p53. Nat Struct Mol Biol. 2012 Sep; 19(9):916-24. PMID: 22864287; PMCID: PMC3454513.
      Citations: 40     Fields:    Translation:HumansCells
    111. Kawabe Y, Wang YX, McKinnell IW, Bedford MT, Rudnicki MA. Carm1 regulates Pax7 transcriptional activity through MLL1/2 recruitment during asymmetric satellite stem cell divisions. Cell Stem Cell. 2012 Sep 07; 11(3):333-45. PMID: 22863532; PMCID: PMC3438319.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    112. Calnan DR, Webb AE, White JL, Stowe TR, Goswami T, Shi X, Espejo A, Bedford MT, Gozani O, Gygi SP, Brunet A. Methylation by Set9 modulates FoxO3 stability and transcriptional activity. Aging (Albany NY). 2012 Jul; 4(7):462-79. PMID: 22820736; PMCID: PMC3433933.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    113. Liu K, Guo Y, Liu H, Bian C, Lam R, Liu Y, Mackenzie F, Rojas LA, Reinberg D, Bedford MT, Xu RM, Min J. Crystal structure of TDRD3 and methyl-arginine binding characterization of TDRD3, SMN and SPF30. PLoS One. 2012; 7(2):e30375. PMID: 22363433; PMCID: PMC3281842.
      Citations: 31     Fields:    Translation:HumansCells
    114. Zhao H, Ho PC, Lo YH, Espejo A, Bedford MT, Hung MC, Wang SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PLoS One. 2012; 7(1):e29416. PMID: 22238610; PMCID: PMC3251568.
      Citations: 22     Fields:    Translation:HumansCells
    115. Cheng D, Vemulapalli V, Bedford MT. Methods applied to the study of protein arginine methylation. Methods Enzymol. 2012; 512:71-92. PMID: 22910203.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    116. Chang Y, Sun L, Kokura K, Horton JR, Fukuda M, Espejo A, Izumi V, Koomen JM, Bedford MT, Zhang X, Shinkai Y, Fang J, Cheng X. MPP8 mediates the interactions between DNA methyltransferase Dnmt3a and H3K9 methyltransferase GLP/G9a. Nat Commun. 2011 Nov 15; 2:533. PMID: 22086334; PMCID: PMC3286832.
      Citations: 60     Fields:    Translation:HumansCells
    117. Badeaux AI, Yang Y, Cardenas K, Vemulapalli V, Chen K, Kusewitt D, Richie E, Li W, Bedford MT. Loss of the methyl lysine effector protein PHF20 impacts the expression of genes regulated by the lysine acetyltransferase MOF. J Biol Chem. 2012 Jan 02; 287(1):429-437. PMID: 22072714; PMCID: PMC3249094.
      Citations: 19     Fields:    Translation:AnimalsCells
    118. Cheng D, Valente S, Castellano S, Sbardella G, Di Santo R, Costi R, Bedford MT, Mai A. Novel 3,5-bis(bromohydroxybenzylidene)piperidin-4-ones as coactivator-associated arginine methyltransferase 1 inhibitors: enzyme selectivity and cellular activity. J Med Chem. 2011 Jul 14; 54(13):4928-32. PMID: 21612300; PMCID: PMC3487391.
      Citations: 27     Fields:    Translation:HumansCells
    119. Guo Q, Bedford MT, Fast W. Discovery of peptidylarginine deiminase-4 substrates by protein array: antagonistic citrullination and methylation of human ribosomal protein S2. Mol Biosyst. 2011 Jul; 7(7):2286-95. PMID: 21584310; PMCID: PMC3251905.
      Citations: 22     Fields:    Translation:HumansCells
    120. Chang Y, Horton JR, Bedford MT, Zhang X, Cheng X. Structural insights for MPP8 chromodomain interaction with histone H3 lysine 9: potential effect of phosphorylation on methyl-lysine binding. J Mol Biol. 2011 May 20; 408(5):807-14. PMID: 21419134; PMCID: PMC3081990.
      Citations: 25     Fields:    Translation:HumansCells
    121. Bissinger EM, Heinke R, Spannhoff A, Eberlin A, Metzger E, Cura V, Hassenboehler P, Cavarelli J, Bedford MT, Sippl W, Jung M, Sch?le R. Acyl derivatives of p-aminosulfonamides and dapsone as new inhibitors of the arginine methyltransferase hPRMT1. Bioorg Med Chem. 2011 Jun 15; 19(12):3717-31. PMID: 21440447.
      Citations: 33     Fields:    Translation:HumansCells
    122. Spannhoff A, Kim YK, Raynal NJ, Gharibyan V, Su MB, Zhou YY, Li J, Castellano S, Sbardella G, Issa JP, Bedford MT. Histone deacetylase inhibitor activity in royal jelly might facilitate caste switching in bees. EMBO Rep. 2011 Mar; 12(3):238-43. PMID: 21331099; PMCID: PMC3059907.
      Citations: 53     Fields:    Translation:AnimalsCells
    123. Butler JS, Zurita-Lopez CI, Clarke SG, Bedford MT, Dent SY. Protein-arginine methyltransferase 1 (PRMT1) methylates Ash2L, a shared component of mammalian histone H3K4 methyltransferase complexes. J Biol Chem. 2011 Apr 08; 286(14):12234-44. PMID: 21285357; PMCID: PMC3069427.
      Citations: 16     Fields:    Translation:HumansCells
    124. Woolard J, Vousden W, Moss SJ, Krishnakumar A, Gammons MV, Nowak DG, Dixon N, Micklefield J, Spannhoff A, Bedford MT, Gregory MA, Martin CJ, Leadlay PF, Zhang MQ, Harper SJ, Bates DO, Wilkinson B. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chem Sci. 2011 Feb 01; 2011(2):273-278. PMID: 22822423; PMCID: PMC3399765.
      Citations: 13     
    125. Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between Arg?1175 methylation and Tyr?1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol. 2011 Feb; 13(2):174-81. PMID: 21258366; PMCID: PMC3048027.
      Citations: 104     Fields:    Translation:HumansCells
    126. Lee YH, Bedford MT, Stallcup MR. Regulated recruitment of tumor suppressor BRCA1 to the p21 gene by coactivator methylation. Genes Dev. 2011 Jan 15; 25(2):176-88. PMID: 21245169; PMCID: PMC3022263.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    127. Yang Y, Lu Y, Espejo A, Wu J, Xu W, Liang S, Bedford MT. TDRD3 is an effector molecule for arginine-methylated histone marks. Mol Cell. 2010 Dec 22; 40(6):1016-23. PMID: 21172665; PMCID: PMC3090733.
      Citations: 111     Fields:    Translation:HumansCells
    128. Cheng D, Bedford MT. Xenoestrogens regulate the activity of arginine methyltransferases. Chembiochem. 2011 Jan 24; 12(2):323-9. PMID: 21243720; PMCID: PMC3142315.
      Citations: 9     Fields:    Translation:HumansCells
    129. Levy D, Kuo AJ, Chang Y, Schaefer U, Kitson C, Cheung P, Espejo A, Zee BM, Liu CL, Tangsombatvisit S, Tennen RI, Kuo AY, Tanjing S, Cheung R, Chua KF, Utz PJ, Shi X, Prinjha RK, Lee K, Garcia BA, Bedford MT, Tarakhovsky A, Cheng X, Gozani O. Lysine methylation of the NF-?B subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-?B signaling. Nat Immunol. 2011 Jan; 12(1):29-36. PMID: 21131967; PMCID: PMC3074206.
      Citations: 140     Fields:    Translation:HumansCells
    130. Di Lorenzo A, Bedford MT. Histone arginine methylation. FEBS Lett. 2011 Jul 07; 585(13):2024-31. PMID: 21074527; PMCID: PMC3409563.
      Citations: 200     Fields:    Translation:HumansAnimalsCells
    131. Liu H, Galka M, Iberg A, Wang Z, Li L, Voss C, Jiang X, Lajoie G, Huang Z, Bedford MT, Li SS. Systematic identification of methyllysine-driven interactions for histone and nonhistone targets. J Proteome Res. 2010 Nov 05; 9(11):5827-36. PMID: 20836566.
      Citations: 22     Fields:    Translation:HumansCells
    132. Kokura K, Sun L, Bedford MT, Fang J. Methyl-H3K9-binding protein MPP8 mediates E-cadherin gene silencing and promotes tumour cell motility and invasion. EMBO J. 2010 Nov 03; 29(21):3673-87. PMID: 20871592; PMCID: PMC2982762.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    133. O'Brien KB, Yadav N, Kocher O, Diruscio A, Ebralidze A, Levantini E, Sng NJ, Bhasin M, Caron T, Kim D, Steidl U, Huang G, Rodig SJ, Bedford MT, Tenen DG, Kobayashi S, Alberich-Jord? M, Halmos B. CARM1 is required for proper control of proliferation and differentiation of pulmonary epithelial cells. Development. 2010 Jul; 137(13):2147-56. PMID: 20530543; PMCID: PMC2882134.
      Citations: 33     Fields:    Translation:AnimalsCells
    134. Zhu F, Berton TR, Kuiper RV, Capps C, Espejo A, McArthur MJ, Bedford MT, van Steeg H, de Vries A, Johnson DG, Doll? ME. Mouse models for the p53 R72P polymorphism mimic human phenotypes. Cancer Res. 2010 Jul 15; 70(14):5851-9. PMID: 20587514; PMCID: PMC2905499.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    135. Short JD, Dere R, Houston KD, Cai SL, Kim J, Bergeron JM, Shen J, Liang J, Bedford MT, Mills GB, Walker CL. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog. 2010 May; 49(5):429-39. PMID: 20146253; PMCID: PMC3818129.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    136. Chang Y, Ganesh T, Horton JR, Spannhoff A, Liu J, Sun A, Zhang X, Bedford MT, Shinkai Y, Snyder JP, Cheng X. Adding a lysine mimic in the design of potent inhibitors of histone lysine methyltransferases. J Mol Biol. 2010 Jul 02; 400(1):1-7. PMID: 20434463; PMCID: PMC2895764.
      Citations: 50     Fields:    Translation:Cells
    137. Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol. 2010 May; 24(5):993-1006. PMID: 20351197; PMCID: PMC2870935.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    138. Milite C, Ragno R, Simeoni S, Mai A, Limongelli V, Novellino E, Bauer I, Brosch G, Spannhoff A, Cheng D, Bedford MT, Sbardella G, Castellano S. Design, synthesis and biological evaluation of carboxy analogues of arginine methyltransferase inhibitor 1 (AMI-1). ChemMedChem. 2010 Mar 01; 5(3):398-414. PMID: 20091730.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    139. Ludes-Meyers JH, Kil H, Parker-Thornburg J, Kusewitt DF, Bedford MT, Aldaz CM. Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One. 2009 Nov 10; 4(11):e7775. PMID: 19936220; PMCID: PMC2777388.
      Citations: 45     Fields:    Translation:HumansAnimals
    140. Quinn AM, Bedford MT, Espejo A, Spannhoff A, Austin CP, Oppermann U, Simeonov A. A homogeneous method for investigation of methylation-dependent protein-protein interactions in epigenetics. Nucleic Acids Res. 2010 Jan; 38(2):e11. PMID: 19897549; PMCID: PMC2811012.
      Citations: 24     Fields:    Translation:Cells
    141. Kim D, Lee J, Cheng D, Li J, Carter C, Richie E, Bedford MT. Enzymatic activity is required for the in vivo functions of CARM1. J Biol Chem. 2010 Jan 08; 285(2):1147-52. PMID: 19897492; PMCID: PMC2801243.
      Citations: 39     Fields:    Translation:AnimalsCells
    142. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M, Ozaki T, Lotz M, Bedford MT, Asahara H. Arginine methyltransferase CARM1/PRMT4 regulates endochondral ossification. BMC Dev Biol. 2009 Sep 02; 9:47. PMID: 19725955; PMCID: PMC2754437.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    143. Bua DJ, Kuo AJ, Cheung P, Liu CL, Migliori V, Espejo A, Casadio F, Bassi C, Amati B, Bedford MT, Guccione E, Gozani O. Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS One. 2009 Aug 26; 4(8):e6789. PMID: 19956676; PMCID: PMC2777412.
      Citations: 55     Fields:    Translation:HumansCells
    144. Lu M, Yang J, Ren Z, Sabui S, Espejo A, Bedford MT, Jacobson RH, Jeruzalmi D, McMurray JS, Chen X. Crystal structure of the three tandem FF domains of the transcription elongation regulator CA150. J Mol Biol. 2009 Oct 23; 393(2):397-408. PMID: 19660470; PMCID: PMC3319151.
      Citations: 5     Fields:    Translation:HumansCells
    145. Repass JF, Laurent MN, Carter C, Reizis B, Bedford MT, Cardenas K, Narang P, Coles M, Richie ER. IL7-hCD25 and IL7-Cre BAC transgenic mouse lines: new tools for analysis of IL-7 expressing cells. Genesis. 2009 Apr; 47(4):281-7. PMID: 19263498.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    146. Chang Y, Zhang X, Horton JR, Upadhyay AK, Spannhoff A, Liu J, Snyder JP, Bedford MT, Cheng X. Structural basis for G9a-like protein lysine methyltransferase inhibition by BIX-01294. Nat Struct Mol Biol. 2009 Mar; 16(3):312-7. PMID: 19219047; PMCID: PMC2676930.
      Citations: 128     Fields:    Translation:Cells
    147. Herrmann F, Pably P, Eckerich C, Bedford MT, Fackelmayer FO. Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family. J Cell Sci. 2009 Mar 01; 122(Pt 5):667-77. PMID: 19208762.
      Citations: 59     Fields:    Translation:HumansCells
    148. Dacwag CS, Bedford MT, Imbalzano AN, Sif S. Distinct protein arginine methyltransferases promote ATP-dependent chromatin remodeling function at different stages of skeletal muscle differentiation. Mol Cell Biol. 2009 Apr; 29(7):1909-21. PMID: 19188441; PMCID: PMC2655603.
      Citations: 62     Fields:    Translation:AnimalsCells
    149. Bedford MT, Clarke SG. Protein arginine methylation in mammals: who, what, and why. Mol Cell. 2009 Jan 16; 33(1):1-13. PMID: 19150423; PMCID: PMC3372459.
      Citations: 716     Fields:    Translation:AnimalsCells
    150. Xie Y, Ke S, Ouyang N, He J, Xie W, Bedford MT, Tian Y. Epigenetic regulation of transcriptional activity of pregnane X receptor by protein arginine methyltransferase 1. J Biol Chem. 2009 Apr 03; 284(14):9199-205. PMID: 19144646; PMCID: PMC2666572.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    151. Zagurovskaya M, Shareef MM, Das A, Reeves A, Gupta S, Sudol M, Bedford MT, Prichard J, Mohiuddin M, Ahmed MM. EGR-1 forms a complex with YAP-1 and upregulates Bax expression in irradiated prostate carcinoma cells. Oncogene. 2009 Feb 26; 28(8):1121-31. PMID: 19137013.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    152. Schotta G, Sengupta R, Kubicek S, Malin S, Kauer M, Celeste A, Pagani M, Opravil S, De La Rosa-Velazquez IA, Espejo A, Bedford MT, Busslinger M, Jenuwein T, Call?n E, Nussenzweig A. A chromatin-wide transition to H4K20 monomethylation impairs genome integrity and programmed DNA rearrangements in the mouse. Genes Dev. 2008 Aug 01; 22(15):2048-61. PMID: 18676810; PMCID: PMC2492754.
      Citations: 212     Fields:    Translation:AnimalsCells
    153. Cheng D, Bedford MT, Valente S, Nebbioso A, Perrone A, Brosch G, Sbardella G, De Bellis F, Miceli M, Altucci L, Mai A. epigenetic multiple ligands: mixed histone/protein methyltransferase, acetyltransferase, and class III deacetylase (sirtuin) inhibitors. J Med Chem. 2008 Apr 10; 51(7):2279-90. PMID: 18348515.
      Citations: 44     Fields:    Translation:HumansCells
    154. Hassa PO, Covic M, Bedford MT, Hottiger MO. Protein arginine methyltransferase 1 coactivates NF-kappaB-dependent gene expression synergistically with CARM1 and PARP1. J Mol Biol. 2008 Mar 28; 377(3):668-78. PMID: 18280497.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    155. Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep. 2008 Feb; 9(2):193-8. PMID: 18188184; PMCID: PMC2246418.
      Citations: 57     Fields:    Translation:AnimalsCells
    156. Bedford MT. Arginine methylation at a glance. J Cell Sci. 2007 Dec 15; 120(Pt 24):4243-6. PMID: 18057026.
      Citations: 147     Fields:    Translation:HumansAnimalsCells
    157. Iberg AN, Espejo A, Cheng D, Kim D, Bedford MT, Michaud-Levesque J, Richard S. Arginine methylation of the histone H3 tail impedes effector binding. J Biol Chem. 2008 Feb 08; 283(6):3006-3010. PMID: 18077460.
      Citations: 93     Fields:    Translation:HumansAnimalsCells
    158. Ludes-Meyers JH, Kil H, Conti CJ, Parker-Thornburg J, Bedford MT, Aldaz CM, Nu?ez MI. WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer. 2007 Dec; 46(12):1129-36. PMID: 17823927; PMCID: PMC4143238.
      Citations: 42     Fields:    Translation:AnimalsCells
    159. Sayegh J, Webb K, Cheng D, Bedford MT, Clarke SG. Regulation of protein arginine methyltransferase 8 (PRMT8) activity by its N-terminal domain. J Biol Chem. 2007 Dec 14; 282(50):36444-53. PMID: 17925405.
      Citations: 47     Fields:    Translation:HumansCells
    160. Huang J, Sengupta R, Espejo AB, Lee MG, Dorsey JA, Richter M, Opravil S, Shiekhattar R, Bedford MT, Jenuwein T, Berger SL. p53 is regulated by the lysine demethylase LSD1. Nature. 2007 Sep 06; 449(7158):105-8. PMID: 17805299.
      Citations: 347     Fields:    Translation:HumansCells
    161. Valente S, Cheng D, Perrone A, Ragno R, Simeoni S, Sbardella G, Brosch G, Nebbioso A, Conte M, Altucci L, Bedford MT, Mai A. Synthesis and biological validation of novel synthetic histone/protein methyltransferase inhibitors. ChemMedChem. 2007 Jul; 2(7):987-91. PMID: 17458842.
      Citations: 20     Fields:    Translation:HumansCells
    162. Swiercz R, Cheng D, Kim D, Bedford MT. Ribosomal protein rpS2 is hypomethylated in PRMT3-deficient mice. J Biol Chem. 2007 Jun 08; 282(23):16917-23. PMID: 17439947.
      Citations: 53     Fields:    Translation:AnimalsCells
    163. Shaaban SA, Bedford MT. Reprogramming the histone code. Chem Biol. 2007 Mar; 14(3):242-4. PMID: 17379139.
      Citations:    Fields:    Translation:Cells
    164. Lake AN, Bedford MT. Protein methylation and DNA repair. Mutat Res. 2007 May 01; 618(1-2):91-101. PMID: 17306845.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    165. Cheng D, Shaaban S, Bedford MT, C?t? J. The arginine methyltransferase CARM1 regulates the coupling of transcription and mRNA processing. Mol Cell. 2007 Jan 12; 25(1):71-83. PMID: 17218272.
      Citations: 182     Fields:    Translation:HumansAnimalsCells
    166. Shi X, Kachirskaia I, Walter KL, Kuo JH, Lake A, Davrazou F, Chan SM, Martin DG, Fingerman IM, Briggs SD, Howe L, Utz PJ, Kutateladze TG, Lugovskoy AA, Bedford MT, Gozani O. Proteome-wide analysis in Saccharomyces cerevisiae identifies several PHD fingers as novel direct and selective binding modules of histone H3 methylated at either lysine 4 or lysine 36. J Biol Chem. 2007 Jan 26; 282(4):2450-5. PMID: 17142463; PMCID: PMC2735445.
      Citations: 132     Fields:    Translation:AnimalsCells
    167. Naeem H, Cheng D, Zhao Q, Underhill C, Tini M, Bedford MT, Torchia J. The activity and stability of the transcriptional coactivator p/CIP/SRC-3 are regulated by CARM1-dependent methylation. Mol Cell Biol. 2007 Jan; 27(1):120-34. PMID: 17043108; PMCID: PMC1800659.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    168. Fabbrizio E, Rodriguez C, Chuchana P, Fauquier L, Cheng D, Theillet C, Vandel L, Bedford MT, Sardet C, El Messaoudi S. Coactivator-associated arginine methyltransferase 1 (CARM1) is a positive regulator of the Cyclin E1 gene. Proc Natl Acad Sci U S A. 2006 Sep 05; 103(36):13351-6. PMID: 16938873; PMCID: PMC1569167.
      Citations: 86     Fields:    Translation:AnimalsCells
    169. Huang Y, Fang J, Bedford MT, Zhang Y, Xu RM. Recognition of histone H3 lysine-4 methylation by the double tudor domain of JMJD2A. Science. 2006 May 05; 312(5774):748-51. PMID: 16601153.
      Citations: 199     Fields:    Translation:HumansCells
    170. Kim J, Daniel J, Espejo A, Lake A, Krishna M, Xia L, Zhang Y, Bedford MT. Tudor, MBT and chromo domains gauge the degree of lysine methylation. EMBO Rep. 2006 Apr; 7(4):397-403. PMID: 16415788; PMCID: PMC1456902.
      Citations: 232     Fields:    Translation:Cells
    171. Sgarra R, Lee J, Tessari MA, Altamura S, Spolaore B, Giancotti V, Bedford MT, Manfioletti G. The AT-hook of the chromatin architectural transcription factor high mobility group A1a is arginine-methylated by protein arginine methyltransferase 6. J Biol Chem. 2006 Feb 17; 281(7):3764-72. PMID: 16293633.
      Citations: 40     Fields:    Translation:HumansCells
    172. Herrmann F, Lee J, Bedford MT, Fackelmayer FO. Dynamics of human protein arginine methyltransferase 1(PRMT1) in vivo. J Biol Chem. 2005 Nov 11; 280(45):38005-10. PMID: 16159886.
      Citations: 43     Fields:    Translation:HumansCells
    173. Lee J, Sayegh J, Daniel J, Clarke S, Bedford MT. PRMT8, a new membrane-bound tissue-specific member of the protein arginine methyltransferase family. J Biol Chem. 2005 Sep 23; 280(38):32890-6. PMID: 16051612.
      Citations: 98     Fields:    Translation:HumansCells
    174. Bedford MT, Richard S. Arginine methylation an emerging regulator of protein function. Mol Cell. 2005 Apr 29; 18(3):263-72. PMID: 15866169.
      Citations: 453     Fields:    Translation:HumansAnimalsCells
    175. Swiercz R, Person MD, Bedford MT. Ribosomal protein S2 is a substrate for mammalian PRMT3 (protein arginine methyltransferase 3). Biochem J. 2005 Feb 15; 386(Pt 1):85-91. PMID: 15473865; PMCID: PMC1134769.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    176. Liang C, Russell RS, Lin R, Bedford MT, Wainberg MA, Boulanger MC, Richard S. Methylation of Tat by PRMT6 regulates human immunodeficiency virus type 1 gene expression. J Virol. 2005 Jan; 79(1):124-31. PMID: 15596808; PMCID: PMC538702.
      Citations: 88     Fields:    Translation:HumansCells
    177. Covic M, Hassa PO, Saccani S, Buerki C, Meier NI, Lombardi C, Imhof R, Bedford MT, Natoli G, Hottiger MO. Arginine methyltransferase CARM1 is a promoter-specific regulator of NF-kappaB-dependent gene expression. EMBO J. 2005 Jan 12; 24(1):85-96. PMID: 15616592; PMCID: PMC544912.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    178. Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT, Aldaz CM. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 2004 Jun 24; 23(29):5049-55. PMID: 15064722; PMCID: PMC4143251.
      Citations: 66     Fields:    Translation:HumansCells
    179. Kim J, Lee J, Yadav N, Wu Q, Carter C, Richie E, Bedford MT, Richard S. Loss of CARM1 results in hypomethylation of thymocyte cyclic AMP-regulated phosphoprotein and deregulated early T cell development. J Biol Chem. 2004 Jun 11; 279(24):25339-44. PMID: 15096520.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    180. Cheng D, Yadav N, King RW, Swanson MS, Weinstein EJ, Bedford MT. Small molecule regulators of protein arginine methyltransferases. J Biol Chem. 2004 Jun 04; 279(23):23892-9. PMID: 15056663.
      Citations: 108     Fields:    Translation:HumansCells
    181. Lee J, Cheng D, Bedford MT. Techniques in protein methylation. Methods Mol Biol. 2004; 284:195-208. PMID: 15173617.
      Citations: 6     Fields:    Translation:HumansCells
    182. Espejo A, Bedford MT. Protein-domain microarrays. Methods Mol Biol. 2004; 264:173-81. PMID: 15020789.
      Citations: 5     Fields:    Translation:AnimalsCells
    183. Sotgia F, Bonuccelli G, Bedford M, Brancaccio A, Mayer U, Wilson MT, Campos-Gonzalez R, Brooks JW, Sudol M, Lisanti MP. Localization of phospho-beta-dystroglycan (pY892) to an intracellular vesicular compartment in cultured cells and skeletal muscle fibers in vivo. Biochemistry. 2003 Jun 17; 42(23):7110-23. PMID: 12795607.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    184. Yadav N, Lee J, Kim J, Shen J, Hu MC, Aldaz CM, Bedford MT. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6464-8. PMID: 12756295; PMCID: PMC164469.
      Citations: 136     Fields:    Translation:AnimalsCells
    185. Boisvert FM, Bedford MT, C?t? J, Boulanger MC, Richard S. Sam68 RNA binding protein is an in vivo substrate for protein arginine N-methyltransferase 1. Mol Biol Cell. 2003 Jan; 14(1):274-87. PMID: 12529443; PMCID: PMC140244.
      Citations: 102     Fields:    Translation:AnimalsCells
    186. Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford M, Aldaz CM. WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res. 2003; 100(1-4):101-10. PMID: 14526170; PMCID: PMC4150470.
      Citations: 38     Fields:    Translation:HumansCells
    187. Espejo A, Bednarek A, Richard S, Bedford MT, C?t? J. A protein-domain microarray identifies novel protein-protein interactions. Biochem J. 2002 Nov 01; 367(Pt 3):697-702. PMID: 12137563; PMCID: PMC1222921.
      Citations: 54     Fields:    Translation:HumansCells
    188. Aasland R, Abrams C, Ampe C, Ball LJ, Bedford MT, Cesareni G, Gimona M, Hurley JH, Jarchau T, Lehto VP, Lemmon MA, Linding R, Mayer BJ, Nagai M, Sudol M, Walter U, Winder SJ. Normalization of nomenclature for peptide motifs as ligands of modular protein domains. FEBS Lett. 2002 Feb 20; 513(1):141-4. PMID: 11911894.
      Citations: 41     Fields:    Translation:Cells
    189. Sotgia F, Lee H, Bedford MT, Petrucci T, Sudol M, Lisanti MP. Tyrosine phosphorylation of beta-dystroglycan at its WW domain binding motif, PPxY, recruits SH2 domain containing proteins. Biochemistry. 2001 Dec 04; 40(48):14585-92. PMID: 11724572.
      Citations: 33     Fields:    Translation:AnimalsCells
    190. Frankel A, Yadav N, Lee J, Branscombe TL, Clarke S, Bedford MT. The novel human protein arginine N-methyltransferase PRMT6 is a nuclear enzyme displaying unique substrate specificity. J Biol Chem. 2002 Feb 01; 277(5):3537-43. PMID: 11724789.
      Citations: 134     Fields:    Translation:HumansCells
    191. Goldstrohm AC, Albrecht TR, Bedford MT, Garcia-Blanco MA, Su?? C. The transcription elongation factor CA150 interacts with RNA polymerase II and the pre-mRNA splicing factor SF1. Mol Cell Biol. 2001 Nov; 21(22):7617-28. PMID: 11604498; PMCID: PMC99933.
      Citations: 62     Fields:    Translation:HumansCells
    192. Sotgia F, Lee JK, Das K, Bedford M, Petrucci TC, Macioce P, Sargiacomo M, Bricarelli FD, Minetti C, Sudol M, Lisanti MP. Caveolin-3 directly interacts with the C-terminal tail of beta -dystroglycan. Identification of a central WW-like domain within caveolin family members. J Biol Chem. 2000 Dec 01; 275(48):38048-58. PMID: 10988290.
      Citations: 56     Fields:    Translation:AnimalsCells
    193. Passani LA, Bedford MT, Faber PW, McGinnis KM, Sharp AH, Gusella JF, Vonsattel JP, MacDonald ME. Huntingtin's WW domain partners in Huntington's disease post-mortem brain fulfill genetic criteria for direct involvement in Huntington's disease pathogenesis. Hum Mol Genet. 2000 Sep 01; 9(14):2175-82. PMID: 10958656.
      Citations: 41     Fields:    Translation:HumansCells
    194. Bedford MT, Sarbassova D, Xu J, Leder P, Yaffe MB. A novel pro-Arg motif recognized by WW domains. J Biol Chem. 2000 Apr 07; 275(14):10359-69. PMID: 10744724.
      Citations: 26     Fields:    Translation:AnimalsCells
    195. Bedford MT, Leder P. The FF domain: a novel motif that often accompanies WW domains. Trends Biochem Sci. 1999 Jul; 24(7):264-5. PMID: 10390614.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    196. Rentschler S, Linn H, Deininger K, Bedford MT, Espanel X, Sudol M. The WW domain of dystrophin requires EF-hands region to interact with beta-dystroglycan. Biol Chem. 1999 Apr; 380(4):431-42. PMID: 10355629.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    197. Bedford MT, Reed R, Leder P. WW domain-mediated interactions reveal a spliceosome-associated protein that binds a third class of proline-rich motif: the proline glycine and methionine-rich motif. Proc Natl Acad Sci U S A. 1998 Sep 01; 95(18):10602-7. PMID: 9724750; PMCID: PMC27941.
      Citations: 54     Fields:    Translation:AnimalsCells
    198. Bedford MT, Chan DC, Leder P. FBP WW domains and the Abl SH3 domain bind to a specific class of proline-rich ligands. EMBO J. 1997 May 01; 16(9):2376-83. PMID: 9171351; PMCID: PMC1169838.
      Citations: 75     Fields:    Translation:AnimalsCells
    199. Deng C, Bedford M, Li C, Xu X, Yang X, Dunmore J, Leder P. Fibroblast growth factor receptor-1 (FGFR-1) is essential for normal neural tube and limb development. Dev Biol. 1997 May 01; 185(1):42-54. PMID: 9169049.
      Citations: 35     Fields:    Translation:Animals
    200. Fishburn CS, Bedford M, Lonai P, Fuchs S. Early expression of D3 dopamine receptors in murine embryonic development. FEBS Lett. 1996 Mar 04; 381(3):257-61. PMID: 8601467.
      Citations: 5     Fields:    Translation:AnimalsCells
    201. Chan DC, Bedford MT, Leder P. Formin binding proteins bear WWP/WW domains that bind proline-rich peptides and functionally resemble SH3 domains. EMBO J. 1996 Mar 01; 15(5):1045-54. PMID: 8605874; PMCID: PMC450002.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    202. Abud HE, Skinner JA, McDonald FJ, Bedford MT, Lonai P, Heath JK. Ectopic expression of Fgf-4 in chimeric mouse embryos induces the expression of early markers of limb development in the lateral ridge. Dev Genet. 1996; 19(1):51-65. PMID: 8792609.
      Citations: 5     Fields:    Translation:AnimalsCells
    203. Bedford M, Arman E, Orr-Urtreger A, Lonai P. Analysis of the Hoxd-3 gene: structure and localization of its sense and natural antisense transcripts. DNA Cell Biol. 1995 Apr; 14(4):295-304. PMID: 7710686.
      Citations: 7     Fields:    Translation:AnimalsCells
    204. Hecht D, Zimmerman N, Bedford M, Avivi A, Yayon A. Identification of fibroblast growth factor 9 (FGF9) as a high affinity, heparin dependent ligand for FGF receptors 3 and 2 but not for FGF receptors 1 and 4. Growth Factors. 1995; 12(3):223-33. PMID: 8619928.
      Citations: 34     Fields:    Translation:AnimalsCells
    205. Orr-Urtreger A, Bedford MT, Burakova T, Arman E, Zimmer Y, Yayon A, Givol D, Lonai P. Developmental localization of the splicing alternatives of fibroblast growth factor receptor-2 (FGFR2). Dev Biol. 1993 Aug; 158(2):475-86. PMID: 8393815.
      Citations: 146     Fields:    Translation:AnimalsCells
    206. Orr-Urtreger A, Bedford MT, Do MS, Eisenbach L, Lonai P. Developmental expression of the alpha receptor for platelet-derived growth factor, which is deleted in the embryonic lethal Patch mutation. Development. 1992 May; 115(1):289-303. PMID: 1322271.
      Citations: 50     Fields:    Translation:Animals
    207. Bedford MT, van Helden PD. A method to analyze allele-specific methylation. Biotechniques. 1990 Dec; 9(6):744-8. PMID: 1980196.
      Citations: 1     Fields:    Translation:HumansCells
    208. van der Merwe AE, Mattheyse FJ, Bedford M, van Helden PD, Rossouw DJ. Allografted keratinocytes used to accelerate the treatment of burn wounds are replaced by recipient cells. Burns. 1990 Jun; 16(3):193-7. PMID: 2383360.
      Citations: 7     Fields:    Translation:HumansCells
    209. Bedford MT, van Helden PD. Analysis of allele-specific methylation. Trends Genet. 1990 May; 6(5):140-1. PMID: 1973312.
      Citations:    Fields:    Translation:Cells
    210. Bedford MT, van Helden PD. Hypomethylation of DNA in pathological conditions of the human prostate. Cancer Res. 1987 Oct 15; 47(20):5274-6. PMID: 2443238.
      Citations: 64     Fields:    Translation:HumansCells
    211. 2 The family of protein arginine metkyltransferases. Enzymes. 24:31-50.
    212. A cellular chemical probe targeting the chromodomains of Polycomb repressive complex 1. Nature Chemical Biology. 12:180-187.
    213. Coactivator-associated arginine methyltransferase-1 function in alveolar epithelial senescence and elastase-induced emphysema susceptibility. American Journal of Respiratory Cell and Molecular Biology. 53:769-781.
    214. G9a-mediated methylation of ERα links the PHF20/MOF histone acetyltransferase complex to hormonal gene expression. Nature Communications. 7.
    215. Binding of 14-3-3 reader proteins to phosphorylated DNMT1 facilitates aberrant DNA methylation and gene expression. Nucleic Acids Research. 44:1642-1656.
    216. Borrelidin modulates the alternative splicing of VEGF in favour of anti-angiogenic isoforms. Chemical Science. 2:273-278.
    217. Methylarginine recognition by tudor domains. 125-148.
    218. Arginine demethylation of G3BP1 promotes stress granule assembly. Journal of Biological Chemistry. 291:22671-22685.
    219. Using oriented peptide array libraries to evaluate methylarginine-specific antibodies and arginine methyltransferase substrate motifs. Scientific Reports. 6.
    220. Mammalian protein arginine methyltransferase 7 (PRMT7) specifically targets RXR sites in lysine- and arginine-rich regions. Journal of Biological Chemistry. 288:37010-37025.
    221. ITCH E3 ubiquitin ligase interacts with Ebola virus VP40 to regulate budding. Journal of Virology. 90:9163-9171.
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