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SHUMEI SONG

TitleAssociate Professor
InstitutionMD Anderson
DepartmentGI Medical Oncology
Address1400 Holcombe Blvd
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Song S, Xu Y, Huo L, Zhao S, Wang R, Li Y, Scott AW, Pizzi MP, Wang Y, Fan Y, Harada K, Jin J, Ma L, Yao X, Shanbhag ND, Gan Q, Roy-Chowdhuri S, Badgwell BD, Wang Z, Wang L, Ajani JA. Patient-derived cell lines and orthotopic mouse model of peritoneal carcinomatosis recapitulate molecular and phenotypic features of human gastric adenocarcinoma. J Exp Clin Cancer Res. 2021 Jun 23; 40(1):207. PMID: 34162421; PMCID: PMC8223395.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Song S, Chen Q, Li Y, Lei G, Scott A, Huo L, Li CY, Estrella JS, Correa A, Pizzi MP, Ma L, Jin J, Liu B, Wang Y, Xiao L, Hofstetter WL, Lee JH, Weston B, Bhutani M, Shanbhag N, Johnson RL, Gan B, Wei S, Ajani JA. Targeting cancer stem cells with a pan-BCL-2 inhibitor in preclinical and clinical settings in patients with gastroesophageal carcinoma. Gut. 2021 12; 70(12):2238-2248. PMID: 33487592; PMCID: PMC9720890.
      Citations: 2     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    3. Ajani JA, Xu Y, Huo L, Wang R, Li Y, Wang Y, Pizzi MP, Scott A, Harada K, Ma L, Yao X, Jin J, Zhao W, Dong X, Badgwell BD, Shanbhag N, Tatlonghari G, Estrella JS, Roy-Chowdhuri S, Kobayashi M, Vykoukal JV, Hanash SM, Calin GA, Peng G, Lee JS, Johnson RL, Wang Z, Wang L, Song S. YAP1 mediates gastric adenocarcinoma peritoneal metastases that are attenuated by YAP1 inhibition. Gut. 2021 01; 70(1):55-66. PMID: 32345613; PMCID: PMC9832914.
      Citations: 14     Fields:    Translation:HumansAnimals
    4. Song S, Wang Z, Li Y, Ma L, Jin J, Scott AW, Xu Y, Estrella JS, Song Y, Liu B, Johnson RL, Ajani JA. PPARd Interacts with the Hippo Coactivator YAP1 to Promote SOX9 Expression and Gastric Cancer Progression. Mol Cancer Res. 2020 03; 18(3):390-402. PMID: 31796534.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    5. Song S, Xie M, Scott AW, Jin J, Ma L, Dong X, Skinner HD, Johnson RL, Ding S, Ajani JA. A Novel YAP1 Inhibitor Targets CSC-Enriched Radiation-Resistant Cells and Exerts Strong Antitumor Activity in Esophageal Adenocarcinoma. Mol Cancer Ther. 2018 02; 17(2):443-454. PMID: 29167315; PMCID: PMC5805581.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    6. Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, Wu TT, Johnson RL, Hung MC, Ajani JA. The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. Clin Cancer Res. 2015 Jun 01; 21(11):2580-90. PMID: 25739674; PMCID: PMC4452384.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    7. Ajani JA, Song S, Hochster HS, Steinberg IB. Introduction. Semin Oncol. 2015 Apr; 42 Suppl 1:S1-2. PMID: 25839663.
      Citations:    Fields:    Translation:HumansCells
    8. Ajani JA, Hochster HS, Steinberg IB, Song S. Cancer stem cells: the promise and the potential. Semin Oncol. 2015 Apr; 42 Suppl 1:S3-17. PMID: 25839664.
      Citations: 127     Fields:    Translation:HumansCells
    9. Elimova E, Shiozaki H, Wadhwa R, Sudo K, Chen Q, Estrella JS, Blum MA, Badgwell B, Das P, Song S, Ajani JA. Medical management of gastric cancer: a 2014 update. World J Gastroenterol. 2014 Oct 14; 20(38):13637-47. PMID: 25320502; PMCID: PMC4194548.
      Citations: 16     Fields:    Translation:Humans
    10. Skinner HD, Lee JH, Bhutani MS, Weston B, Hofstetter W, Komaki R, Shiozaki H, Wadhwa R, Sudo K, Elimova E, Song S, Ye Y, Huang M, Ajani J, Wu X. A validated miRNA profile predicts response to therapy in esophageal adenocarcinoma. Cancer. 2014 Dec 01; 120(23):3635-41. PMID: 25091571; PMCID: PMC4239178.
      Citations: 30     Fields:    Translation:Humans
    11. Li Y, Liu Z, Liu H, Wang LE, Onodera H, Suzuki A, Suzuki K, Wadhwa R, Elimova E, Sudo K, Shiozaki H, Estrella J, Lee JS, Song S, Tan D, Ajani JA, Wei Q. Potentially functional variants in the core nucleotide excision repair genes predict survival in Japanese gastric cancer patients. Carcinogenesis. 2014 Sep; 35(9):2031-8. PMID: 24990617.
      Citations: 9     Fields:    Translation:HumansCells
    12. Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, Hung MC, Johnson RL. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 2014 Aug 01; 74(15):4170-82. PMID: 24906622; PMCID: PMC4136429.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    13. Honjo S, Ajani JA, Scott AW, Chen Q, Skinner HD, Stroehlein J, Johnson RL, Song S. Metformin sensitizes chemotherapy by targeting cancer stem cells and the mTOR pathway in esophageal cancer. Int J Oncol. 2014 Aug; 45(2):567-74. PMID: 24859412; PMCID: PMC4091970.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    14. Chen QR, Guan F, Song SM, Jin JK, Lei DS, Chen CM, Lei JH, Chen ZW, Niu AO. Allograft inflammatory factor-1 alleviates liver disease of BALB/c mice infected with Schistosoma japonicum. Parasitol Res. 2014 Jul; 113(7):2629-39. PMID: 24816816.
      Citations: 2     Fields:    Translation:Animals
    15. Wadhwa R, Elimova E, Shiozaki H, Sudo K, Blum MA, Estrella JS, Chen Q, Song S, Ajani JA. Anti-angiogenic agent ramucirumab: meaningful or marginal? Expert Rev Anticancer Ther. 2014 Apr; 14(4):367-79. PMID: 24605771.
      Citations: 5     Fields:    Translation:Humans
    16. Ajani JA, Wang X, Song S, Suzuki A, Taketa T, Sudo K, Wadhwa R, Hofstetter WL, Komaki R, Maru DM, Lee JH, Bhutani MS, Weston B, Baladandayuthapani V, Yao Y, Honjo S, Scott AW, Skinner HD, Johnson RL, Berry D. ALDH-1 expression levels predict response or resistance to preoperative chemoradiation in resectable esophageal cancer patients. Mol Oncol. 2014 Feb; 8(1):142-9. PMID: 24210755; PMCID: PMC3946849.
      Citations: 55     Fields:    Translation:HumansCells
    17. Wadhwa R, Song S, Lee JS, Yao Y, Wei Q, Ajani JA. Gastric cancer-molecular and clinical dimensions. Nat Rev Clin Oncol. 2013 Nov; 10(11):643-55. PMID: 24061039; PMCID: PMC3927982.
      Citations: 195     Fields:    Translation:HumansAnimals
    18. Song S, Maru DM, Ajani JA, Chan CH, Honjo S, Lin HK, Correa A, Hofstetter WL, Davila M, Stroehlein J, Mishra L. Loss of TGF-? adaptor ?2SP activates notch signaling and SOX9 expression in esophageal adenocarcinoma. Cancer Res. 2013 Apr 01; 73(7):2159-69. PMID: 23536563; PMCID: PMC3745222.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    19. Song S, Ajani JA. The role of microRNAs in cancers of the upper gastrointestinal tract. Nat Rev Gastroenterol Hepatol. 2013 Feb; 10(2):109-18. PMID: 23165235; PMCID: PMC3855852.
      Citations: 48     Fields:    Translation:HumansAnimals
    20. Song S, Ji B, Ramachandran V, Wang H, Hafley M, Logsdon C, Bresalier RS. Overexpressed galectin-3 in pancreatic cancer induces cell proliferation and invasion by binding Ras and activating Ras signaling. PLoS One. 2012; 7(8):e42699. PMID: 22900040; PMCID: PMC3416861.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    21. Mendelson J, Song S, Li Y, Maru DM, Mishra B, Davila M, Hofstetter WL, Mishra L. Dysfunctional transforming growth factor-? signaling with constitutively active Notch signaling in Barrett's esophageal adenocarcinoma. Cancer. 2011 Aug 15; 117(16):3691-702. PMID: 21305538; PMCID: PMC3236645.
      Citations: 29     Fields:    Translation:HumansCells
    22. Song S, Byrd JC, Guha S, Liu KF, Koul D, Bresalier RS. Induction of MUC5AC mucin by conjugated bile acids in the esophagus involves the phosphatidylinositol 3-kinase/protein kinase C/activator protein-1 pathway. Cancer. 2011 Jun 01; 117(11):2386-97. PMID: 24048786; PMCID: PMC3116027.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Song S, Guan B, Men T, Hoque A, Lotan R, Xu XC. Antitumor effect of retinoic acid receptor-beta2 associated with suppression of cyclooxygenase-2. Cancer Prev Res (Phila). 2009 Mar; 2(3):274-80. PMID: 19258542; PMCID: PMC3415716.
      Citations: 4     Fields:    Translation:HumansAnimals
    24. Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res. 2009 Feb 15; 69(4):1343-9. PMID: 19190323; PMCID: PMC2990400.
      Citations: 73     Fields:    Translation:HumansCells
    25. Song S, Krishnan K, Liu K, Bresalier RS. Polyphenon E inhibits the growth of human Barrett's and aerodigestive adenocarcinoma cells by suppressing cyclin D1 expression. Clin Cancer Res. 2009 Jan 15; 15(2):622-31. PMID: 19147768; PMCID: PMC2925407.
      Citations: 9     Fields:    Translation:HumansCells
    26. Song S, Guha S, Liu K, Buttar NS, Bresalier RS. COX-2 induction by unconjugated bile acids involves reactive oxygen species-mediated signalling pathways in Barrett's oesophagus and oesophageal adenocarcinoma. Gut. 2007 Nov; 56(11):1512-21. PMID: 17604323; PMCID: PMC2095641.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    27. Song S, Lippman SM, Zou Y, Ye X, Ajani JA, Xu XC. Induction of cyclooxygenase-2 by benzo[a]pyrene diol epoxide through inhibition of retinoic acid receptor-beta 2 expression. Oncogene. 2005 Dec 15; 24(56):8268-76. PMID: 16170369.
      Citations: 23     Fields:    Translation:AnimalsCells
    28. Song S, Byrd JC, Mazurek N, Liu K, Koo JS, Bresalier RS. Galectin-3 modulates MUC2 mucin expression in human colon cancer cells at the level of transcription via AP-1 activation. Gastroenterology. 2005 Nov; 129(5):1581-91. PMID: 16285957.
      Citations: 26     Fields:    Translation:HumansCells
    29. Song S, Byrd JC, Koo JS, Bresalier RS. Bile acids induce MUC2 overexpression in human colon carcinoma cells. Cancer. 2005 Apr 15; 103(8):1606-14. PMID: 15754327.
      Citations: 16     Fields:    Translation:HumansCells
    30. Jiang B, Liu W, Qu H, Meng L, Song S, Ouyang T, Shou C. A novel peptide isolated from a phage display peptide library with trastuzumab can mimic antigen epitope of HER-2. J Biol Chem. 2005 Feb 11; 280(6):4656-62. PMID: 15536075.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    31. An P, Lei H, Zhang J, Song S, He L, Jin G, Liu X, Wu J, Meng L, Liu M, Shou C. Suppression of tumor growth and metastasis by a VEGFR-1 antagonizing peptide identified from a phage display library. Int J Cancer. 2004 Aug 20; 111(2):165-73. PMID: 15197767.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    32. Ning JY, Sun GX, Huang S, Ma H, An P, Meng L, Song SM, Wu J, Shou CC. Identification of antigens by monoclonal antibody PD4 and its expression in Escherichia coli. World J Gastroenterol. 2003 Oct; 9(10):2164-8. PMID: 14562370; PMCID: PMC4656455.
      Citations: 4     Fields:    Translation:HumansCells
    33. Xu XC, Shappell SB, Liang Z, Song S, Menter D, Subbarayan V, Iyengar S, Tang DG, Lippman SM. Reduced 15S-lipoxygenase-2 expression in esophageal cancer specimens and cells and upregulation in vitro by the cyclooxygenase-2 inhibitor, NS398. Neoplasia. 2003 Mar-Apr; 5(2):121-7. PMID: 12659684; PMCID: PMC1502398.
      Citations: 15     Fields:    Translation:HumansCells
    34. Hetian L, Ping A, Shumei S, Xiaoying L, Luowen H, Jian W, Lin M, Meisheng L, Junshan Y, Chengchao S. A novel peptide isolated from a phage display library inhibits tumor growth and metastasis by blocking the binding of vascular endothelial growth factor to its kinase domain receptor. J Biol Chem. 2002 Nov 08; 277(45):43137-42. PMID: 12183450.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    35. Li M, Song S, Lippman SM, Zhang XK, Liu X, Lotan R, Xu XC. Induction of retinoic acid receptor-beta suppresses cyclooxygenase-2 expression in esophageal cancer cells. Oncogene. 2002 Jan 17; 21(3):411-8. PMID: 11821953.
      Citations: 14     Fields:    Translation:HumansCells
    36. Tian X, Song S, Wu J, Meng L, Dong Z, Shou C. Vascular endothelial growth factor: acting as an autocrine growth factor for human gastric adenocarcinoma cell MGC803. Biochem Biophys Res Commun. 2001 Aug 24; 286(3):505-12. PMID: 11511087.
      Citations: 28     Fields:    Translation:HumansCells
    37. Song S, Xu XC. Effect of benzo[a]pyrene diol epoxide on expression of retinoic acid receptor-beta in immortalized esophageal epithelial cells and esophageal cancer cells. Biochem Biophys Res Commun. 2001 Mar 09; 281(4):872-7. PMID: 11237740.
      Citations: 13     Fields:    Translation:HumansCells
    38. Song S, Zeng L, Wu J. [Cloning and monoclonal antibody preparation of VEGF receptor KDR extracellular V-VII domain and KDR expression in carcinomas of different origins]. Zhonghua Zhong Liu Za Zhi. 1999 Mar; 21(2):96-8. PMID: 11776867.
      Citations: 1     Fields:    Translation:HumansAnimals
    39. Ramucirumab for the treatment of gastroesophageal cancers. Expert Opinion on Orphan Drugs. 3:737-746.
    40. Exploiting Molecular and Immune Biology of Gastric and Gastroesophageal Adenocarcinomas to Discover Novel Therapeutic Targets. Annals of Surgical Oncology. 1-6.
    41. ABT-263 induces apoptosis and synergizes with chemotherapy by targeting stemness pathways in esophageal cancer. Oncotarget. 6:25883-25896.
    42. The hippo coactivator YAP1 mediates EGFR overexpression and confers chemoresistance in esophageal cancer. Clinical Cancer Research. 21:2580-2590.
    43. Reply to dysfunctional transforming growth factor-β signaling with constitutively active notch signaling in barrett's esophageal adenocarcinoma. Cancer. 118:1957-1958.
    44. Large tumor suppressor homologs 1 and 2 regulate mouse liver progenitor cell proliferation and maturation through antagonism of the coactivators YAP and TAZ. Hepatology.
    45. Anal canal cancer. Expert Opinion on Orphan Drugs. 2:137-146.
    46. Cloning and expression of truncated KDR binding to vascular endothelial growth factor. Progress in Biochemistry and Biophysics. 26:483-484.
    47. Inhibition of monoclonal antibodies against extracellular I-IV domains of vascular endothelial cell growth factor receptor KDR on the proliferation EC and formation of chicken embryo blood vessels. Chinese Journal of Microbiology and Immunology. 20:327-330.
    48. Proteomics approach to identify biomarkers for upper gastrointestinal cancer. Expert Review of Proteomics. 13:1041-1053.
    49. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-β-Catenin Signaling in Colorectal Cancer. EBioMedicine. 13:113-124.
    50. Expression of VEGF receptor KDR in different originated carcinomas. Chinese Journal of Cancer Research. 10:182-186.
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