TitleAssociate Professor
InstitutionMD Anderson
Address7777 Knight Rd
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Stitzlein LM, Adams JT, Stitzlein EN, Dudley RW, Chandra J. Current and future therapeutic strategies for high-grade gliomas leveraging the interplay between epigenetic regulators and kinase signaling networks. J Exp Clin Cancer Res. 2024 Jan 05; 43(1):12. PMID: 38183103; PMCID: PMC10768151.
      Citations: 1     Fields:    Translation:HumansCells
    2. Sharma M, Barravecchia I, Teis R, Cruz J, Mumby R, Ziemke EK, Espinoza CE, Krishnamoorthy V, Magnuson B, Ljungman M, Koschmann C, Chandra J, Whitehead CE, Sebolt-Leopold JS, Galban S. Targeting DNA Repair and Survival Signaling in Diffuse Intrinsic Pontine Gliomas to Prevent Tumor Recurrence. Mol Cancer Ther. 2024 Jan 03; 23(1):24-34. PMID: 37723046; PMCID: PMC10762335.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Rodriguez M, Fekry B, Murphy B, Figueroa M, Cheng T, Raber M, Wartenberg L, Bell D, Triche L, Crawford K, Ma H, Allton K, Ahmed R, Tran J, Ranieri C, Konopleva M, Barton M, Nunez C, Eckel-Mahan K, Chandra J. Feasible diet and circadian interventions reduce in?vivo progression of FLT3-ITD-positive acute myeloid leukemia. Cancer Med. 2024 Jan; 13(2):e6949. PMID: 38334474; PMCID: PMC10854450.
      Citations:    Fields:    Translation:HumansAnimals
    4. Hudson EA, Burgermaster M, Isis SM, Jeans MR, Vandyousefi S, Landry MJ, Seguin-Fowler R, Chandra J, Davis J. School-based intervention impacts availability of vegetables and beverages in participants' homes. Front Nutr. 2023; 10:1278125. PMID: 38162521; PMCID: PMC10754996.
    5. Figueroa M, Ma H, Alfayez M, Morales-Mantilla DE, Wang F, Lu Y, Estecio MR, King KY, Kleinerman E, Moghaddam SJ, Daver N, Andreeff M, Konopleva M, DiNardo C, Chandra J. Cigarette smoke exposure accelerates AML progression in FLT3-ITD models. Blood Adv. 2023 11 14; 7(21):6624-6629. PMID: 37486624; PMCID: PMC10628807.
      Citations:    Fields:    Translation:Humans
    6. Jeyabal P, Bhagat A, Wang F, Roth M, Livingston JA, Gilchrist SC, Banchs J, Hildebrandt MAT, Chandra J, Deswal A, Koutroumpakis E, Wang J, Daw NC, Honey TA, Kleinerman ES. Circulating microRNAs and Cytokines as Prognostic Biomarkers for Doxorubicin-Induced Cardiac Injury and for Evaluating the Effectiveness of an Exercise Intervention. Clin Cancer Res. 2023 11 01; 29(21):4430-4440. PMID: 37651264.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Wooten SV, Amini B, Livingston JA, Hildebrandt MAT, Chandra J, Gilchrist SC, Roth M, Kleinerman E. Poor Sit-to-Stand Performance in Adolescent and Young Adult Patients with Sarcoma. J Adolesc Young Adult Oncol. 2023 Dec; 12(6):821-827. PMID: 37155195.
      Citations:    Fields:    Translation:Humans
    8. Jeans MR, Landry MJ, Vandyousefi S, Hudson EA, Burgermaster M, Bray MS, Chandra J, Davis JN. Effects of a School-Based Gardening, Cooking, and Nutrition Cluster Randomized Controlled Trial on Unprocessed and Ultra-Processed Food Consumption. J Nutr. 2023 07; 153(7):2073-2084. PMID: 37116658; PMCID: PMC10375509.
      Citations:    Fields:    Translation:HumansAnimals
    9. Stitzlein LM, Gangadharan A, Walsh LM, Nam D, Espejo AB, Singh MM, Patel KH, Lu Y, Su X, Ezhilarasan R, Gumin J, Singh S, Sulman E, Lang FF, Chandra J. Comparison of pharmacological inhibitors of lysine-specific demethylase 1 in glioblastoma stem cells reveals inhibitor-specific efficacy profiles. Front Neurol. 2023; 14:1112207. PMID: 37082446; PMCID: PMC10111022.
    10. Garcia MB, Schadler KL, Chandra J, Clinton SK, Courneya KS, Cruz-Monserrate Z, Daniel CR, Dannenberg AJ, Demark-Wahnefried W, Dewhirst MW, Fabian CJ, Hursting SD, Irwin ML, Iyengar NM, McQuade JL, Schmitz KH, Basen-Engquist K. Translating energy balance research from the bench to the clinic to the community: Parallel animal-human studies in cancer. CA Cancer J Clin. 2023 Jul-Aug; 73(4):425-442. PMID: 36825928.
      Citations: 1     Fields:    Translation:HumansAnimals
    11. Raber M, Costigan M, Chandra J, Basen-Engquist K. Cooking After Cancer: the Structure and Implementation of a Community-Based Cooking Program for Cancer Survivors. J Cancer Educ. 2022 06; 37(3):539-545. PMID: 32754833; PMCID: PMC7862418.
      Citations: 3     Fields:    Translation:HumansAnimals
    12. Kannan S, Irwin ME, Herbrich SM, Cheng T, Patterson LL, Aitken MJL, Bhalla K, You MJ, Konopleva M, Zweidler-McKay PA, Chandra J. Targeting the NRF2/HO-1 Antioxidant Pathway in FLT3-ITD-Positive AML Enhances Therapy Efficacy. Antioxidants (Basel). 2022 Apr 05; 11(4). PMID: 35453402; PMCID: PMC9027903.
    13. Cheng T, Kiser K, Grasse L, Iles L, Bartholomeusz G, Samaniego F, Orlowski RZ, Chandra J. Expression of histone deacetylase (HDAC) family members in bortezomib-refractory multiple myeloma and modulation by panobinostat. Cancer Drug Resist. 2021; 4(4):888-902. PMID: 34888496; PMCID: PMC8653980.
      Citations: 1     
    14. Wang F, Chandra J, Kleinerman ES. Exercise intervention decreases acute and late doxorubicin-induced cardiotoxicity. Cancer Med. 2021 11; 10(21):7572-7584. PMID: 34523825; PMCID: PMC8559466.
      Citations: 1     Fields:    Translation:Animals
    15. Wartenberg L, Raber M, Chandra J. Unique Features of a Web-Based Nutrition Website for Childhood Cancer Populations: Descriptive Study. J Med Internet Res. 2021 09 13; 23(9):e24515. PMID: 34515643; PMCID: PMC8477295.
      Citations: 1     Fields:    Translation:Humans
    16. Wooten SV, Roth M, Livingston JA, Hildebrandt MAT, Chandra J, Amini B, Kleinerman ES, Gilchrist SC. Short-Term Changes in Skeletal Muscle Mass After Anthracycline Administration in Adolescent and Young Adult Sarcoma Patients. J Adolesc Young Adult Oncol. 2022 06; 11(3):320-322. PMID: 34388045; PMCID: PMC9529368.
      Citations:    Fields:    Translation:Humans
    17. Bailey CP, Wang R, Figueroa M, Zhang S, Wang L, Chandra J. Computational immune infiltration analysis of pediatric high-grade gliomas (pHGGs) reveals differences in immunosuppression and prognosis by tumor location. Comput Syst Oncol. 2021 Sep; 1(3). PMID: 34723252; PMCID: PMC8553216.
      Citations: 1     
    18. Morales-Mantilla DE, Huang X, Erice P, Porter P, Zhang Y, Figueroa M, Chandra J, King KY, Kheradmand F, Rodr?guez A. Cigarette Smoke Exposure in Mice using a Whole-Body Inhalation System. J Vis Exp. 2020 10 22; (164). PMID: 33165327; PMCID: PMC7996447.
      Citations: 1     Fields:    Translation:AnimalsPHPublic Health
    19. Bailey CP, Figueroa M, Gangadharan A, Yang Y, Romero MM, Kennis BA, Yadavilli S, Henry V, Collier T, Monje M, Lee DA, Wang L, Nazarian J, Gopalakrishnan V, Zaky W, Becher OJ, Chandra J. Pharmacologic inhibition of lysine-specific demethylase 1 as a therapeutic and immune-sensitization strategy in pediatric high-grade glioma. Neuro Oncol. 2020 09 29; 22(9):1302-1314. PMID: 32166329; PMCID: PMC7523459.
      Citations: 15     Fields:    Translation:HumansAnimals
    20. Bailey CP, Figueroa M, Gangadharan A, Lee DA, Chandra J. Scaffolding LSD1 Inhibitors Impair NK Cell Metabolism and Cytotoxic Function Through Depletion of Glutathione. Front Immunol. 2020; 11:2196. PMID: 33042135; PMCID: PMC7527493.
      Citations: 5     Fields:    Translation:HumansCells
    21. Swartz MC, Teague AK, Wells SJ, Honey T, Fu M, Mahadeo KM, Kabiri LS, Chandra J, Moody K, Schadler K. Feasibility and Acceptability Findings of an Energy Balance Data Repository of Children, Adolescents, and Young Adults with Cancer. J Clin Med. 2020 Sep 06; 9(9). PMID: 32899945; PMCID: PMC7564246.
    22. Sun Y, Bailey CP, Sadighi Z, Zaky W, Chandra J. Pediatric high-grade glioma: aberrant epigenetics and kinase signaling define emerging therapeutic opportunities. J Neurooncol. 2020 Oct; 150(1):17-26. PMID: 32504402; PMCID: PMC10141680.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    23. Raber M, Baranowski T, Crawford K, Sharma SV, Schick V, Markham C, Jia W, Sun M, Steinman E, Chandra J. The Healthy Cooking Index: Nutrition Optimizing Home Food Preparation Practices across Multiple Data Collection Methods. J Acad Nutr Diet. 2020 07; 120(7):1119-1132. PMID: 32280056; PMCID: PMC7321919.
      Citations: 4     Fields:    Translation:Humans
    24. Murphy BR, Raber MP, Crawford KD, Grasse L, Wartenberg L, Wu J, Dibaj SS, Chandra J. High Rates of Obesity at Presentation Persist into Survivorship across Childhood Cancer Types. Child Obes. 2020 06; 16(4):250-257. PMID: 32176517; PMCID: PMC7262646.
      Citations:    Fields:    Translation:Humans
    25. Raber M, Basen-Engquist K, Moran NE, Chandra J. The Healthy Cooking Index does not Predict the Carotenoid Content of Home-Cooked Meals. Nutrients. 2020 Feb 19; 12(2). PMID: 32092844; PMCID: PMC7071392.
      Citations: 1     Fields:    Translation:HumansAnimals
    26. Cohen J, Collins L, Gregerson L, Chandra J, Cohn RJ. Nutritional concerns of survivors of childhood cancer: A "First World" perspective. Pediatr Blood Cancer. 2020 06; 67 Suppl 3:e28193. PMID: 31994836.
      Citations:    Fields:    Translation:Humans
    27. Raber M, Wu J, Donnella H, Knouse P, Pise M, Munsell M, Liu D, Chandra J. Cellular Oxidative Stress in Pediatric Leukemia and Lymphoma Patients Undergoing Treatment Is Associated with Protein Consumption. Nutrients. 2019 Dec 27; 12(1). PMID: 31892127; PMCID: PMC7019785.
      Citations: 2     Fields:    Translation:HumansCells
    28. Raber M, Crawford K, Baranowski T, Sharma SV, Schick V, Markham C, Roth M, Chandra J. Exploring food preparation practices in families with and without school-aged childhood cancer survivors. Public Health Nutr. 2020 02; 23(3):410-415. PMID: 31538553; PMCID: PMC7024001.
      Citations: 1     Fields:    Translation:Humans
    29. Raber M, Crawford K, Baranowski T, Sharma SV, Schick V, Markham C, Roth M, Wakefield CE, Chandra J. Meal planning values impacted by the cancer experience in families with school-aged survivors-a qualitative exploration and recommendations for intervention development. Support Care Cancer. 2020 Mar; 28(3):1305-1313. PMID: 31243584; PMCID: PMC6930971.
      Citations: 1     Fields:    Translation:Humans
    30. Kannan S, Aitken MJL, Herbrich SM, Golfman LS, Hall MG, Mak DH, Burks JK, Song G, Konopleva M, Mullighan CG, Chandra J, Zweidler-McKay PA. Antileukemia Effects of Notch-Mediated Inhibition of Oncogenic PLK1 in B-Cell Acute Lymphoblastic Leukemia. Mol Cancer Ther. 2019 09; 18(9):1615-1627. PMID: 31227645; PMCID: PMC6726528.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    31. Bailey CP, Figueroa M, Mohiuddin S, Zaky W, Chandra J. Cutting Edge Therapeutic Insights Derived from Molecular Biology of Pediatric High-Grade Glioma and Diffuse Intrinsic Pontine Glioma (DIPG). Bioengineering (Basel). 2018 Oct 18; 5(4). PMID: 30340362; PMCID: PMC6315414.
      Citations: 7     
    32. Raber M, Huynh TN, Crawford K, Kim S, Chandra J. Development and Feasibility of a Community-Based, Culturally Flexible Colorectal Cancer Prevention Program. J Community Health. 2018 10; 43(5):882-885. PMID: 29532214; PMCID: PMC6119495.
      Citations: 3     Fields:    Translation:Humans
    33. Herbrich SM, Kannan S, Nolo RM, Hornbaker M, Chandra J, Zweidler-McKay PA. Characterization of TRKA signaling in acute myeloid leukemia. Oncotarget. 2018 Jul 10; 9(53):30092-30105. PMID: 30046390; PMCID: PMC6059018.
      Citations: 4     Fields:    
    34. Eterovic AK, Maher OM, Chandra J, Chen K, Huse J, Zaky W. Metachronous Medulloblastoma in a Child With Successfully Treated Neuroblastoma: Case Report and Novel Findings of DNA Sequencing. J Natl Compr Canc Netw. 2018 06; 16(6):683-691. PMID: 29891519.
      Citations: 1     Fields:    Translation:Humans
    35. Wang F, Iskra B, Kleinerman E, Alvarez-Florez C, Andrews T, Shaw A, Chandra J, Schadler K, Aune GJ. Aerobic Exercise During Early Murine Doxorubicin Exposure Mitigates Cardiac Toxicity. J Pediatr Hematol Oncol. 2018 04; 40(3):208-215. PMID: 29557918; PMCID: PMC6876617.
      Citations: 20     Fields:    Translation:Animals
    36. Rivera-Del Valle N, Cheng T, Irwin ME, Donnella H, Singh MM, Chandra J. Combinatorial effects of histone deacetylase inhibitors (HDACi), vorinostat and entinostat, and adaphostin are characterized by distinct redox alterations. Cancer Chemother Pharmacol. 2018 03; 81(3):483-495. PMID: 29313067; PMCID: PMC5837827.
      Citations: 5     Fields:    Translation:HumansCells
    37. Zaky W, Manton C, Miller CP, Khatua S, Gopalakrishnan V, Chandra J. The ubiquitin-proteasome pathway in adult and pediatric brain tumors: biological insights and therapeutic opportunities. Cancer Metastasis Rev. 2017 12; 36(4):617-633. PMID: 29071526.
      Citations: 4     Fields:    Translation:HumansAnimals
    38. Schadler KL, Kleinerman ES, Chandra J. Diet and exercise interventions for pediatric cancer patients during therapy: tipping the scales for better outcomes. Pediatr Res. 2018 01; 83(1-1):50-56. PMID: 29068433; PMCID: PMC5865395.
      Citations: 7     Fields:    Translation:HumansAnimals
    39. Raber M, Crawford K, Chandra J. Healthy cooking classes at a children's cancer hospital and patient/survivor summer camps: initial reactions and feasibility. Public Health Nutr. 2017 Jun; 20(9):1650-1656. PMID: 28463101; PMCID: PMC5953415.
      Citations: 7     Fields:    Translation:Humans
    40. Li R, Donnella H, Knouse P, Raber M, Crawford K, Swartz MC, Wu J, Liu D, Chandra J. A randomized nutrition counseling intervention in pediatric leukemia patients receiving steroids results in reduced caloric intake. Pediatr Blood Cancer. 2017 02; 64(2):374-380. PMID: 27615542.
      Citations: 4     Fields:    Translation:Humans
    41. Raber M, Chandra J, Upadhyaya M, Schick V, Strong LL, Durand C, Sharma S. An evidence-based conceptual framework of healthy cooking. Prev Med Rep. 2016 Dec; 4:23-8. PMID: 27413657; PMCID: PMC4929050.
      Citations: 24     
    42. Raber M, Swartz MC, Santa Maria D, O'Connor T, Baranowski T, Li R, Chandra J. Parental involvement in exercise and diet interventions for childhood cancer survivors: a systematic review. Pediatr Res. 2016 09; 80(3):338-46. PMID: 27064243.
      Citations: 12     Fields:    Translation:Humans
    43. Swartz MC, Basen-Engquist KM, Markham C, Lyons EJ, Cox M, Chandra J, Ater JL, Askins MA, Scheurer ME, Lupo PJ, Hill R, Murray J, Chan W, Swank PR. Psychometric Analysis of the Three-Factor Eating Questionnaire-R18V2 in Adolescent and Young Adult-Aged Central Nervous System Tumor Survivors. J Adolesc Young Adult Oncol. 2016 09; 5(3):278-85. PMID: 27042872; PMCID: PMC5031087.
      Citations:    Fields:    Translation:Humans
    44. Manton CA, Johnson B, Singh M, Bailey CP, Bouchier-Hayes L, Chandra J. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Sci Rep. 2016 Jan 25; 6:18953. PMID: 26804704; PMCID: PMC4726202.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    45. Luan J, Chu Z, Chandra J, Zhang P. Small Molecular Inhibitors Targeting Chromatin Regulating Proteins for Cancer. Curr Protein Pept Sci. 2016; 17(5):455-62. PMID: 26796303.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    46. Fulbright JM, Egas-Bejar DE, Huh WW, Chandra J. Analysis of redox and apoptotic effects of anthracyclines to delineate a cardioprotective strategy. Cancer Chemother Pharmacol. 2015 Dec; 76(6):1297-307. PMID: 26515054; PMCID: PMC4651800.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    47. Irwin ME, Johnson BP, Manshouri R, Amin HM, Chandra J. A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies. Oncotarget. 2015 Sep 15; 6(27):23631-46. PMID: 26136341; PMCID: PMC4695141.
      Citations: 9     Fields:    Translation:HumansCells
    48. Li R, Raber M, Chandra J. Developing a healthy web-based cookbook for pediatric cancer patients and survivors: rationale and methods. JMIR Res Protoc. 2015 Mar 31; 4(1):e37. PMID: 25840596; PMCID: PMC4397390.
      Citations: 8     
    49. Singh MM, Johnson B, Venkatarayan A, Flores ER, Zhang J, Su X, Barton M, Lang F, Chandra J. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro Oncol. 2015 Nov; 17(11):1463-73. PMID: 25795306; PMCID: PMC4648298.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    50. Braun FK, Mathur R, Sehgal L, Wilkie-Grantham R, Chandra J, Berkova Z, Samaniego F. Inhibition of methyltransferases accelerates degradation of cFLIP and sensitizes B-cell lymphoma cells to TRAIL-induced apoptosis. PLoS One. 2015; 10(3):e0117994. PMID: 25738497; PMCID: PMC4349737.
      Citations: 10     Fields:    Translation:HumansCells
    51. Corrales-Medina FF, Manton CA, Orlowski RZ, Chandra J. Efficacy of panobinostat and marizomib in acute myeloid leukemia and bortezomib-resistant models. Leuk Res. 2015 Mar; 39(3):371-9. PMID: 25612941; PMCID: PMC4420632.
      Citations: 4     Fields:    Translation:HumansCells
    52. Santa Maria D, Swartz MC, Markham C, Chandra J, McCurdy S, Basen-Engquist K. Exploring parental factors related to weight management in survivors of childhood central nervous system tumors. J Pediatr Oncol Nurs. 2014 Mar-Apr; 31(2):84-94. PMID: 24608701.
      Citations: 1     Fields:    Translation:Humans
    53. Irwin ME, Nelson LD, Santiago-O'Farrill JM, Knouse PD, Miller CP, Palla SL, Siwak DR, Mills GB, Estrov Z, Li S, Kornblau SM, Hughes DP, Chandra J. Small molecule ErbB inhibitors decrease proliferative signaling and promote apoptosis in philadelphia chromosome-positive acute lymphoblastic leukemia. PLoS One. 2013; 8(8):e70608. PMID: 23936456; PMCID: PMC3731286.
      Citations: 13     Fields:    Translation:HumansCells
    54. Beltran A, Li R, Ater J, Baranowski J, Buday R, Thompson D, Chandra J, Baranowski T. Adapting a Videogame to the Needs of Pediatric Cancer Patients and Survivors. Games Health J. 2013 Aug; 2(4):213-21. PMID: 26192225.
      Citations: 3     Fields:    
    55. Dent SY, Chandra J. The lasting influence of LSD1 in the blood. Elife. 2013 Jun 18; 2:e00963. PMID: 23795303; PMCID: PMC3687340.
      Citations: 7     Fields:    Translation:HumansCells
    56. Badr H, Chandra J, Paxton RJ, Ater JL, Urbauer D, Cruz CS, Demark-Wahnefried W. Health-related quality of life, lifestyle behaviors, and intervention preferences of survivors of childhood cancer. J Cancer Surviv. 2013 Dec; 7(4):523-34. PMID: 23749663; PMCID: PMC3825822.
      Citations: 43     Fields:    Translation:Humans
    57. Papke CL, Cao J, Kwartler CS, Villamizar C, Byanova KL, Lim SM, Sreenivasappa H, Fischer G, Pham J, Rees M, Wang M, Chaponnier C, Gabbiani G, Khakoo AY, Chandra J, Trache A, Zimmer W, Milewicz DM. Smooth muscle hyperplasia due to loss of smooth muscle a-actin is driven by activation of focal adhesion kinase, altered p53 localization and increased levels of platelet-derived growth factor receptor-?. Hum Mol Genet. 2013 Aug 01; 22(15):3123-37. PMID: 23591991; PMCID: PMC3699068.
      Citations: 22     Fields:    Translation:AnimalsCells
    58. Singh MM, Howard A, Irwin ME, Gao Y, Lu X, Multani A, Chandra J. Expression and activity of Fyn mediate proliferation and blastic features of chronic myelogenous leukemia. PLoS One. 2012; 7(12):e51611. PMID: 23284724; PMCID: PMC3524192.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    59. Irwin ME, Rivera-Del Valle N, Chandra J. Redox control of leukemia: from molecular mechanisms to therapeutic opportunities. Antioxid Redox Signal. 2013 Apr 10; 18(11):1349-83. PMID: 22900756; PMCID: PMC3584825.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    60. Co-Reyes E, Li R, Huh W, Chandra J. Malnutrition and obesity in pediatric oncology patients: causes, consequences, and interventions. Pediatr Blood Cancer. 2012 Dec 15; 59(7):1160-7. PMID: 22948929; PMCID: PMC3468697.
      Citations: 19     Fields:    Translation:Humans
    61. Singh MM, Irwin ME, Gao Y, Ban K, Shi P, Arlinghaus RB, Amin HM, Chandra J. Inhibition of the NADPH oxidase regulates heme oxygenase 1 expression in chronic myeloid leukemia. Cancer. 2012 Jul 01; 118(13):3433-45. PMID: 22139798; PMCID: PMC3297684.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    62. Miller CP, Manton CA, Hale R, Debose L, Macherla VR, Potts BC, Palladino MA, Chandra J. Specific and prolonged proteasome inhibition dictates apoptosis induction by marizomib and its analogs. Chem Biol Interact. 2011 Oct 15; 194(1):58-68. PMID: 21864512; PMCID: PMC3186881.
      Citations: 4     Fields:    Translation:HumansCells
    63. Hu J, Liu X, Hughes D, Esteva FJ, Liu B, Chandra J, Li S. Herceptin conjugates linked by EDC boost direct tumor cell death via programmed tumor cell necrosis. PLoS One. 2011; 6(8):e23270. PMID: 21853100; PMCID: PMC3154407.
      Citations: 6     Fields:    Translation:HumansCells
    64. Miller CP, Singh MM, Rivera-Del Valle N, Manton CA, Chandra J. Therapeutic strategies to enhance the anticancer efficacy of histone deacetylase inhibitors. J Biomed Biotechnol. 2011; 2011:514261. PMID: 21765634; PMCID: PMC3134392.
      Citations: 31     Fields:    Translation:Humans
    65. Singh MM, Manton CA, Bhat KP, Tsai WW, Aldape K, Barton MC, Chandra J. Inhibition of LSD1 sensitizes glioblastoma cells to histone deacetylase inhibitors. Neuro Oncol. 2011 Aug; 13(8):894-903. PMID: 21653597; PMCID: PMC3145466.
      Citations: 63     Fields:    Translation:HumansCells
    66. Potts BC, Albitar MX, Anderson KC, Baritaki S, Berkers C, Bonavida B, Chandra J, Chauhan D, Cusack JC, Fenical W, Ghobrial IM, Groll M, Jensen PR, Lam KS, Lloyd GK, McBride W, McConkey DJ, Miller CP, Neuteboom ST, Oki Y, Ovaa H, Pajonk F, Richardson PG, Roccaro AM, Sloss CM, Spear MA, Valashi E, Younes A, Palladino MA. Marizomib, a proteasome inhibitor for all seasons: preclinical profile and a framework for clinical trials. Curr Cancer Drug Targets. 2011 Mar; 11(3):254-84. PMID: 21247382; PMCID: PMC3712795.
      Citations: 83     Fields:    Translation:HumansAnimals
    67. Fulbright JM, Huh W, Anderson P, Chandra J. Can anthracycline therapy for pediatric malignancies be less cardiotoxic? Curr Oncol Rep. 2010 Nov; 12(6):411-9. PMID: 20820959.
      Citations: 13     Fields:    Translation:Humans
    68. Rivera-Del Valle N, Gao S, Miller CP, Fulbright J, Gonzales C, Sirisawad M, Steggerda S, Wheler J, Balasubramanian S, Chandra J. PCI-24781, a Novel Hydroxamic Acid HDAC Inhibitor, Exerts Cytotoxicity and Histone Alterations via Caspase-8 and FADD in Leukemia Cells. Int J Cell Biol. 2010; 2010:207420. PMID: 20145726; PMCID: PMC2817379.
      Citations: 18     
    69. Merritt WM, Danes CG, Shahzad MM, Lin YG, Kamat AA, Han LY, Spannuth WA, Nick AM, Mangala LS, Stone RL, Kim HS, Gershenson DM, Jaffe RB, Coleman RL, Chandra J, Sood AK. Anti-angiogenic properties of metronomic topotecan in ovarian carcinoma. Cancer Biol Ther. 2009 Aug; 8(16):1596-603. PMID: 19738426; PMCID: PMC3916970.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    70. Shi P, Chandra J, Sun X, Gergely M, Cortes JE, Garcia-Manero G, Arlinghaus RB, Lai R, Amin HM. Inhibition of IGF-IR tyrosine kinase induces apoptosis and cell cycle arrest in imatinib-resistant chronic myeloid leukaemia cells. J Cell Mol Med. 2010 Jun; 14(6B):1777-92. PMID: 19508387; PMCID: PMC3444523.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    71. Chandra J. Oxidative stress by targeted agents promotes cytotoxicity in hematologic malignancies. Antioxid Redox Signal. 2009 May; 11(5):1123-37. PMID: 19018667; PMCID: PMC2842131.
      Citations: 19     Fields:    Translation:HumansCells
    72. Howard AN, Bridges KA, Meyn RE, Chandra J. ABT-737, a BH3 mimetic, induces glutathione depletion and oxidative stress. Cancer Chemother Pharmacol. 2009 Dec; 65(1):41-54. PMID: 19404643.
      Citations: 11     Fields:    Translation:HumansCells
    73. Kopetz S, Lesslie DP, Dallas NA, Park SI, Johnson M, Parikh NU, Kim MP, Abbruzzese JL, Ellis LM, Chandra J, Gallick GE. Synergistic activity of the SRC family kinase inhibitor dasatinib and oxaliplatin in colon carcinoma cells is mediated by oxidative stress. Cancer Res. 2009 May 01; 69(9):3842-9. PMID: 19383922; PMCID: PMC2709758.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    74. Miller CP, Rudra S, Keating MJ, Wierda WG, Palladino M, Chandra J. Caspase-8 dependent histone acetylation by a novel proteasome inhibitor, NPI-0052: a mechanism for synergy in leukemia cells. Blood. 2009 Apr 30; 113(18):4289-99. PMID: 19182209; PMCID: PMC2676087.
      Citations: 28     Fields:    Translation:HumansCells
    75. Gao Y, Howard A, Ban K, Chandra J. Oxidative stress promotes transcriptional up-regulation of Fyn in BCR-ABL1-expressing cells. J Biol Chem. 2009 Mar 13; 284(11):7114-25. PMID: 19131339; PMCID: PMC2652262.
      Citations: 14     Fields:    Translation:HumansCells
    76. Ban K, Gao Y, Amin HM, Howard A, Miller C, Lin Q, Leng X, Munsell M, Bar-Eli M, Arlinghaus RB, Chandra J. BCR-ABL1 mediates up-regulation of Fyn in chronic myelogenous leukemia. Blood. 2008 Mar 01; 111(5):2904-8. PMID: 18180382; PMCID: PMC2254539.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    77. Gao S, Mobley A, Miller C, Boklan J, Chandra J. Potentiation of reactive oxygen species is a marker for synergistic cytotoxicity of MS-275 and 5-azacytidine in leukemic cells. Leuk Res. 2008 May; 32(5):771-80. PMID: 18031811; PMCID: PMC2320596.
      Citations: 30     Fields:    Translation:HumansCells
    78. Miller CP, Ban K, Dujka ME, McConkey DJ, Munsell M, Palladino M, Chandra J. NPI-0052, a novel proteasome inhibitor, induces caspase-8 and ROS-dependent apoptosis alone and in combination with HDAC inhibitors in leukemia cells. Blood. 2007 Jul 01; 110(1):267-77. PMID: 17356134; PMCID: PMC1896116.
      Citations: 79     Fields:    Translation:HumansAnimalsCells
    79. Long J, Manchandia T, Ban K, Gao S, Miller C, Chandra J. Adaphostin cytoxicity in glioblastoma cells is ROS-dependent and is accompanied by upregulation of heme oxygenase-1. Cancer Chemother Pharmacol. 2007 Mar; 59(4):527-35. PMID: 16924499.
      Citations: 13     Fields:    Translation:HumansCells
    80. Orsolic N, Golemovic M, Scappini B, Manshouri T, Chandra J, Basic I, Giles F, Kantarjian H, Verstovsek S, Quint?s-Cardama A. Adaphostin has significant and selective activity against chronic and acute myeloid leukemia cells. Cancer Sci. 2006 Sep; 97(9):952-60. PMID: 16822295.
      Citations: 7     Fields:    Translation:HumansCells
    81. Ruiz S, Krupnik Y, Keating M, Chandra J, Palladino M, McConkey D. The proteasome inhibitor NPI-0052 is a more effective inducer of apoptosis than bortezomib in lymphocytes from patients with chronic lymphocytic leukemia. Mol Cancer Ther. 2006 Jul; 5(7):1836-43. PMID: 16891470.
      Citations: 35     Fields:    Translation:HumansCells
    82. Chandra J, Tracy J, Loegering D, Flatten K, Verstovsek S, Beran M, Gorre M, Estrov Z, Donato N, Talpaz M, Sawyers C, Bhalla K, Karp J, Sausville E, Kaufmann SH. Adaphostin-induced oxidative stress overcomes BCR/ABL mutation-dependent and -independent imatinib resistance. Blood. 2006 Mar 15; 107(6):2501-6. PMID: 16291594; PMCID: PMC1895739.
      Citations: 31     Fields:    Translation:HumansCells
    83. Meng XW, Chandra J, Loegering D, Van Becelaere K, Kottke TJ, Gore SD, Karp JE, Sebolt-Leopold J, Kaufmann SH. Central role of Fas-associated death domain protein in apoptosis induction by the mitogen-activated protein kinase kinase inhibitor CI-1040 (PD184352) in acute lymphocytic leukemia cells in vitro. J Biol Chem. 2003 Nov 21; 278(47):47326-39. PMID: 12963734.
      Citations: 25     Fields:    Translation:HumansCells
    84. Chandra J, Hackbarth J, Le S, Loegering D, Bone N, Bruzek LM, Narayanan VL, Adjei AA, Kay NE, Tefferi A, Karp JE, Sausville EA, Kaufmann SH. Involvement of reactive oxygen species in adaphostin-induced cytotoxicity in human leukemia cells. Blood. 2003 Dec 15; 102(13):4512-9. PMID: 12920036.
      Citations: 18     Fields:    Translation:HumansCells
    85. Kagan VE, Gleiss B, Tyurina YY, Tyurin VA, Liu SX, Serinkan FB, Arroyo A, Chandra J, Orrenius S, Fadeel B, Elenstr?m-Magnusson C. A role for oxidative stress in apoptosis: oxidation and externalization of phosphatidylserine is required for macrophage clearance of cells undergoing Fas-mediated apoptosis. J Immunol. 2002 Jul 01; 169(1):487-99. PMID: 12077280.
      Citations: 80     Fields:    Translation:HumansCells
    86. Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem. 2002 Jun 07; 277(23):20301-8. PMID: 11909872.
      Citations: 56     Fields:    Translation:HumansCells
    87. Chandra J, Mansson E, Gogvadze V, Kaufmann SH, Albertioni F, Orrenius S. Resistance of leukemic cells to 2-chlorodeoxyadenosine is due to a lack of calcium-dependent cytochrome c release. Blood. 2002 Jan 15; 99(2):655-63. PMID: 11781251.
      Citations: 2     Fields:    Translation:Cells
    88. Mow BM, Chandra J, Svingen PA, Hallgren CG, Weisberg E, Kottke TJ, Narayanan VL, Litzow MR, Griffin JD, Sausville EA, Tefferi A, Kaufmann SH. Effects of the Bcr/abl kinase inhibitors STI571 and adaphostin (NSC 680410) on chronic myelogenous leukemia cells in vitro. Blood. 2002 Jan 15; 99(2):664-71. PMID: 11781252.
      Citations: 17     Fields:    Translation:HumansCells
    89. Mow BM, Blajeski AL, Chandra J, Kaufmann SH. Apoptosis and the response to anticancer therapy. Curr Opin Oncol. 2001 Nov; 13(6):453-62. PMID: 11673685.
      Citations: 18     Fields:    Translation:Humans
    90. Chandra J, Wang Y, Xu D, Knaust E, Spasokoukotskaja T, Liliemark E, Eriksson S, Albertioni F, Lotfi K, M?nsson E. Pharmacological basis for cladribine resistance in a human acute T lymphoblastic leukaemia cell line selected for resistance to etoposide. Br J Haematol. 2001 May; 113(2):339-46. PMID: 11380397.
      Citations: 3     Fields:    Translation:HumansCells
    91. Lundberg M, Johansson C, Chandra J, Enoksson M, Jacobsson G, Ljung J, Johansson M, Holmgren A. Cloning and expression of a novel human glutaredoxin (Grx2) with mitochondrial and nuclear isoforms. J Biol Chem. 2001 Jul 13; 276(28):26269-75. PMID: 11297543.
      Citations: 93     Fields:    Translation:HumansCells
    92. Chandra J, Yang SN, Zaitsev S, Juntti-Berggren L, Berggren PO, Zhivotovsky B, Orrenius S, K?hler M. Effects of serum from patients with type 1 diabetes on primary cerebellar granule cells. Diabetes. 2001 Feb; 50 Suppl 1:S77-81. PMID: 11272207.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    93. Chandra J, Zhivotovsky B, Zaitsev S, Juntti-Berggren L, Berggren PO, Orrenius S. Role of apoptosis in pancreatic beta-cell death in diabetes. Diabetes. 2001 Feb; 50 Suppl 1:S44-7. PMID: 11272200.
      Citations: 42     Fields:    Translation:HumansAnimals
    94. Robertson JD, Chandra J, Gogvadze V, Orrenius S. Biological reactive intermediates and mechanisms of cell death. Adv Exp Med Biol. 2001; 500:1-10. PMID: 11764918.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    95. Chandra J, Samali A, Orrenius S. Triggering and modulation of apoptosis by oxidative stress. Free Radic Biol Med. 2000 Aug; 29(3-4):323-33. PMID: 11035261.
      Citations: 285     Fields:    Translation:HumansAnimals
    96. Multani AS, Ozen M, Narayan S, Kumar V, Chandra J, McConkey DJ, Newman RA, Pathak S. Caspase-dependent apoptosis induced by telomere cleavage and TRF2 loss. Neoplasia. 2000 Jul-Aug; 2(4):339-45. PMID: 11005568; PMCID: PMC1550291.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    97. Fadeel B, Gleiss B, Chandra J, Wiedmer T, Sims PJ, Henter JI, Orrenius S, Samali A, H?gstrand K. Phosphatidylserine exposure during apoptosis is a cell-type-specific event and does not correlate with plasma membrane phospholipid scramblase expression. Biochem Biophys Res Commun. 1999 Dec 20; 266(2):504-11. PMID: 10600532.
      Citations: 33     Fields:    Translation:HumansCells
    98. McConkey DJ, Chandra J. Protease activation and glucocorticoid-induced apoptosis in chronic lymphocytic leukemia. Leuk Lymphoma. 1999 May; 33(5-6):421-31. PMID: 10342570.
      Citations:    Fields:    Translation:HumansAnimalsCells
    99. Bold RJ, Chandra J, McConkey DJ. Gemcitabine-induced programmed cell death (apoptosis) of human pancreatic carcinoma is determined by Bcl-2 content. Ann Surg Oncol. 1999 Apr-May; 6(3):279-85. PMID: 10340887.
      Citations: 38     Fields:    Translation:HumansCells
    100. Multani AS, Chandra J, Mcconker J, Sen S, Cabral TF, Pathak S. Cell death in paclitaxel-dependent chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats. Oncol Res. 1999; 11(10):455-60. PMID: 10850886.
      Citations: 1     Fields:    Translation:AnimalsCells
    101. Chandra J, Niemer I, Gilbreath J, Kliche KO, Andreeff M, Freireich EJ, Keating M, McConkey DJ. Proteasome inhibitors induce apoptosis in glucocorticoid-resistant chronic lymphocytic leukemic lymphocytes. Blood. 1998 Dec 01; 92(11):4220-9. PMID: 9834227.
      Citations: 15     Fields:    Translation:HumansCells
    102. Bouvet M, Bold RJ, Lee J, Evans DB, Abbruzzese JL, Chiao PJ, McConkey DJ, Chandra J, Chada S, Fang B, Roth JA. Adenovirus-mediated wild-type p53 tumor suppressor gene therapy induces apoptosis and suppresses growth of human pancreatic cancer [seecomments]. Ann Surg Oncol. 1998 Dec; 5(8):681-8. PMID: 9869513.
      Citations: 27     Fields:    Translation:HumansCells
    103. Balasubramanian K, Chandra J, Schroit AJ. Immune clearance of phosphatidylserine-expressing cells by phagocytes. The role of beta2-glycoprotein I in macrophage recognition. J Biol Chem. 1997 Dec 05; 272(49):31113-7. PMID: 9388264.
      Citations: 26     Fields:    Translation:HumansCells
    104. Chandra J, Gilbreath J, Freireich EJ, Kliche KO, Andreeff M, Keating M, McConkey DJ. Protease activation is required for glucocorticoid-induced apoptosis in chronic lymphocytic leukemic lymphocytes. Blood. 1997 Nov 01; 90(9):3673-81. PMID: 9345052.
      Citations: 5     Fields:    Translation:HumansCells
    105. McConkey DJ, Chandra J, Wright S, Plunkett W, McDonnell TJ, Reed JC, Keating M. Apoptosis sensitivity in chronic lymphocytic leukemia is determined by endogenous endonuclease content and relative expression of BCL-2 and BAX. J Immunol. 1996 Apr 01; 156(7):2624-30. PMID: 8786328.
      Citations: 16     Fields:    Translation:Humans
    106. A NOX2/Egr-1/Fyn pathway delineates new targets for TKI-resistant malignancies. Oncotarget. 6:23631-23646.
    107. Analysis of redox and apoptotic effects of anthracyclines to delineate a cardioprotective strategy. Cancer Chemotherapy and Pharmacology. 76:1297-1307.
    108. Induction of cell death by the novel proteasome inhibitor marizomib in glioblastoma in vitro and in vivo. Scientific Reports. 6.
    109. Parental involvement in exercise and diet interventions for childhood cancer survivors. Pediatric Research. 80:338-346.
    110. Small molecular inhibitors targeting chromatin regulating proteins for cancer. Current Protein and Peptide Science. 17:455-462.
    111. An evidence-based conceptual framework of healthy cooking. Preventive Medicine Reports. 4:23-28.
    112. Psychometric analysis of the three-factor eating questionnaire-R18V2 in adolescent and young adult-aged central nervous system tumor survivors. Journal of Adolescent and Young Adult Oncology. 5:278-285.
    113. A randomized nutrition counseling intervention in pediatric leukemia patients receiving steroids results in reduced caloric intake. Pediatric Blood and Cancer. 64:374-380.
    114. Preclinical activity of combined HDAC and KDM1A inhibition in glioblastoma. Neuro-Oncology. 17:1463-1473.
    115. Development and Feasibility of a Culturally Sensitive Cooking and Physical Activity Program Designed for Obese Hispanic Families. Infant, Child, and Adolescent Nutrition. 7:86-93.
    116. Adapting a Videogame to the Needs of Pediatric Cancer Patients and Survivors. Games for Health Journal. 2:213-221.
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