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BULENT OZPOLAT

TitleAssociate Professor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Rodriguez-Aguayo C, Del C Monroig P, Redis RS, Bayraktar E, Almeida MI, Ivan C, Fuentes-Mattei E, Rashed MH, Chavez-Reyes A, Ozpolat B, Mitra R, Sood AK, Calin GA, Lopez-Berestein G. Author Correction: Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer. Cell Discov. 2023 Nov 08; 9(1):111. PMID: 37940695.
      Citations:    
    2. Bayraktar R, Pichler M, Kanlikilicer P, Ivan C, Bayraktar E, Kahraman N, Aslan B, Oguztuzun S, Ulasli M, Arslan A, Calin G, Lopez-Berestein G, Ozpolat B. Correction: MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase. Oncotarget. 2023 Oct 31; 14:908-909. PMID: 37921671; PMCID: PMC10624201.
      Citations:    Fields:    
    3. Guler A, Hamurcu Z, Ulutabanca H, Cinar V, Nurdinov N, Erdem S, Ozpolat B. Flavopiridol Suppresses Cell Proliferation and Migration and Induces Apoptotic Cell Death by Inhibiting Oncogenic FOXM1 Signaling in IDH Wild-Type and IDH-Mutant GBM Cells. Mol Neurobiol. 2023 Sep 07. PMID: 37676393.
      Citations:    Fields:    
    4. Dilmac S, Ozpolat B. Mechanisms of PARP-Inhibitor-Resistance in BRCA-Mutated Breast Cancer and New Therapeutic Approaches. Cancers (Basel). 2023 Jul 16; 15(14). PMID: 37509303; PMCID: PMC10378018.
      Citations:    
    5. Ozyurt R, Ozpolat B. Therapeutic Landscape of AXL Receptor Kinase in Triple-Negative Breast Cancer. Mol Cancer Ther. 2023 07 05; 22(7):818-832. PMID: 37028809.
      Citations: 2     Fields:    Translation:HumansCells
    6. Erdogan MA, Yuca E, Ashour A, Gurbuz N, Sencan S, Ozpolat B. SCN5A promotes the growth and lung metastasis of triple-negative breast cancer through EF2-kinase signaling. Life Sci. 2022 Dec 13; 121282. PMID: 36526045.
      Citations:    Fields:    
    7. Ozyurt R, Ozpolat B. Molecular Mechanisms of Anti-Estrogen Therapy Resistance and Novel Targeted Therapies. Cancers (Basel). 2022 Oct 24; 14(21). PMID: 36358625; PMCID: PMC9655708.
      Citations: 7     
    8. Yan G, Luna A, Wang H, Bozorgui B, Li X, Sanchez M, Dereli Z, Kahraman N, Kara G, Chen X, Zheng C, McGrail D, Sahni N, Lu Y, Babur O, Cokol M, Lim B, Ozpolat B, Sander C, Mills GB, Korkut A. BET inhibition induces vulnerability to MCL1 targeting through upregulation of fatty acid synthesis pathway in breast cancer. Cell Rep. 2022 09 13; 40(11):111304. PMID: 36103824; PMCID: PMC9523722.
      Citations:    
    9. Cinar V, Hamurcu Z, Guler A, Nurdinov N, Ozpolat B. Serotonin 5-HT7 receptor is a biomarker poor prognostic factor and induces proliferation of triple-negative breast cancer cells through FOXM1. Breast Cancer. 2022 Nov; 29(6):1106-1120. PMID: 36006564.
      Citations:    
    10. Kara G, Arun B, Calin GA, Ozpolat B. miRacle of microRNA-Driven Cancer Nanotherapeutics. Cancers (Basel). 2022 Aug 06; 14(15). PMID: 35954481; PMCID: PMC9367393.
      Citations:    
    11. Rodriguez-Aguayo C, Bayraktar E, Ivan C, Aslan B, Mai J, He G, Mangala LS, Jiang D, Nagaraja AS, Ozpolat B, Chavez-Reyes A, Ferrari M, Mitra R, Siddik ZH, Shen H, Yang X, Sood AK, Lopez-Berestein G. Corrigendum to "PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis" [EBioMedicine 40 (2019) 290-304]. EBioMedicine. 2022 Sep; 83:104194. PMID: 35914489; PMCID: PMC9340498.
      Citations:    
    12. Comert Onder F, Siyah P, Durdagi S, Ay M, Ozpolat B. Novel etodolac derivatives as eukaryotic elongation factor 2 kinase (eEF2K) inhibitors for targeted cancer therapy. RSC Med Chem. 2022 Jul 20; 13(7):840-849. PMID: 35923718; PMCID: PMC9298183.
      Citations:    
    13. Butner JD, Dogra P, Chung C, Nizzero S, Plodinec M, Li X, Pan PY, Chen SH, Cristini V, Ozpolat B, Calin GA, Wang Z, Ruiz-Ram?rez J. Dedifferentiation-mediated stem cell niche maintenance in early-stage ductal carcinoma in situ progression: insights from a multiscale modeling study. Cell Death Dis. 2022 May 21; 13(5):485. PMID: 35597788; PMCID: PMC9124196.
      Citations:    Fields:    Translation:Humans
    14. Dogra P, Butner JD, Chung C, Hooda-Nehra A, Pasqualini R, Arap W, Cristini V, Calin GA, Ozpolat B, Wang Z, Ram?rez JR, Pel?ez MJ. Translational Modeling Identifies Synergy between Nanoparticle-Delivered miRNA-22 and Standard-of-Care Drugs in Triple-Negative Breast Cancer. Pharm Res. 2022 Mar; 39(3):511-528. PMID: 35294699; PMCID: PMC8986735.
      Citations: 2     Fields:    Translation:HumansCells
    15. Tatar G, Taskin Tok T, Ozpolat B, Ay M. Structure prediction of eukaryotic elongation factor-2 kinase and identification of the binding mechanisms of its inhibitors: homology modeling, molecular docking, and molecular dynamics simulation. J Biomol Struct Dyn. 2022; 40(24):13355-13365. PMID: 30880628.
      Citations: 1     Fields:    
    16. El Sabeh M, Vincent KL, Afrin S, Motamedi M, Saada J, Yang J, Ozpolat B, Kilic GS, Borahay MA. Simvastatin-loaded liposome nanoparticles treatment for uterine leiomyoma in a patient-derived xenograft mouse model: a pilot study. J Obstet Gynaecol. 2022 Aug; 42(6):2139-2143. PMID: 35166183; PMCID: PMC9741872.
      Citations:    Fields:    
    17. Kara G, Calin GA, Ozpolat B. RNAi-based therapeutics and tumor targeted delivery in cancer. Adv Drug Deliv Rev. 2022 03; 182:114113. PMID: 35063535.
      Citations: 5     Fields:    Translation:Humans
    18. Gurbuz N, Kahraman N, Sonmez HE, Mokhlis HA, Kosar PA, Ozpolat B. miRNA-193b-5p Suppresses Pancreatic Cancer Cell Proliferation, Invasion, Epithelial Mesenchymal Transition, and Tumor Growth by Inhibiting eEF2K. Anticancer Agents Med Chem. 2022; 22(14):2607-2618. PMID: 35718922.
      Citations:    Fields:    Translation:HumansAnimalsCells
    19. El-Arabey AA, Denizli M, Kanlikilicer P, Bayraktar R, Ivan C, Rashed M, Kabil N, Ozpolat B, Calin GA, Salama SA, Abd-Allah AR, Sood AK, Lopez-Berestein G. CORRIGENDUM: GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma. Cell Signal. 2022 Jan; 89:110147. PMID: 34772589.
      Citations:    Fields:    
    20. Chaganty BKR, Qiu S, Lu Y, Lopez-Berestein G, Ozpolat B, Fan Z. Redirecting host preexisting influenza A virus immunity for cancer immunotherapy. Cancer Immunol Immunother. 2022 Jul; 71(7):1611-1623. PMID: 34731283; PMCID: PMC8563826.
      Citations:    Fields:    Translation:HumansAnimalsCells
    21. Durdagi S, Kahraman N, Uslu TN, Kandemir H, Atici EB, Ozpolat B, Onder FC, Ay M. Novel inhibitors of eukaryotic elongation factor 2 kinase: In silico, synthesis and in vitro studies. Bioorg Chem. 2021 11; 116:105296. PMID: 34488125.
      Citations:    Fields:    Translation:HumansCells
    22. Deng K, Tesikova M, Jin Y, Frengen NS, Kahraman N, Mokhlis HM, Ozpolat B, Kildal W, Danielsen HE, Fazli L, Rennie PS, Banerjee PP, Jin Y, Kuzu OF, Saatcioglu F, P?llmann N, Livg?rd M, ?ren A. Stress-Mediated Reprogramming of Prostate Cancer One-Carbon Cycle Drives Disease Progression. Cancer Res. 2021 08 01; 81(15):4066-4078. PMID: 34183356.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    23. Comert Onder F, Kahraman N, Bellur Atici E, Cagir A, Kandemir H, Tatar G, Taskin Tok T, Kara G, Karliga B, Durdagi S, Ay M, Ozpolat B. Correction to "Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth In Vivo". ACS Pharmacol Transl Sci. 2021 Jun 11; 4(3):1247. PMID: 34151214; PMCID: PMC8205232.
      Citations:    
    24. Shin DH, Nguyen T, Ozpolat B, Lang F, Alonso M, Gomez-Manzano C, Fueyo J. Current strategies to circumvent the antiviral immunity to optimize cancer virotherapy. J Immunother Cancer. 2021 04; 9(4). PMID: 33795384; PMCID: PMC8021759.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Comert Onder F, Kahraman N, Bellur Atici E, Cagir A, Kandemir H, Tatar G, Taskin Tok T, Kara G, Karliga B, Durdagi S, Ozpolat B, Ay M. Target-Driven Design of a Coumarinyl Chalcone Scaffold Based Novel EF2 Kinase Inhibitor Suppresses Breast Cancer Growth In Vivo. ACS Pharmacol Transl Sci. 2021 Apr 09; 4(2):926-940. PMID: 33860211; PMCID: PMC8033782.
      Citations:    
    26. Ozpolat B, Hamurcu Z, Sener EF, Taheri S, Nalbantoglu U, Kokcu ND, Tahtasakal R, Cinar V, Guler A, Ozkul Y, D?nmez-Altuntas H. MicroRNA profiling identifies Forkhead box transcription factor M1 (FOXM1) regulated miR-186 and miR-200b alterations in triple negative breast cancer. Cell Signal. 2021 07; 83:109979. PMID: 33744419.
      Citations: 1     Fields:    Translation:HumansCells
    27. Karakas D, Ozpolat B. The Role of LncRNAs in Translation. Noncoding RNA. 2021 Feb 20; 7(1). PMID: 33672592; PMCID: PMC8005997.
      Citations: 8     
    28. Erdogan MA, Ashour A, Yuca E, Gorgulu K, Ozpolat B. Targeting eukaryotic elongation factor-2 kinase suppresses the growth and peritoneal metastasis of ovarian cancer. Cell Signal. 2021 05; 81:109938. PMID: 33539938.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    29. Butner JD, Fuentes D, Ozpolat B, Calin GA, Zhou X, Lowengrub J, Cristini V, Wang Z. Corrections to "A multiscale Agent-Based Model of Ductal Carcinoma in Situ". IEEE Trans Biomed Eng. 2021 02; 68(2):736. PMID: 33476261; PMCID: PMC8446858.
      Citations:    Fields:    
    30. Mohapatra S, Pioppini C, Ozpolat B, Calin GA. Non-coding RNAs regulation of macrophage polarization in cancer. Mol Cancer. 2021 02 01; 20(1):24. PMID: 33522932; PMCID: PMC7849140.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    31. Sencan S, Tanriover M, Ulasli M, Karakas D, Ozpolat B. UV radiation resistance-associated gene (UVRAG) promotes cell proliferation, migration, invasion by regulating cyclin-dependent kinases (CDK) and integrin-?/Src signaling in breast cancer cells. Mol Cell Biochem. 2021 May; 476(5):2075-2084. PMID: 33515382.
      Citations: 1     Fields:    Translation:HumansCells
    32. Gorur A, Bayraktar R, Ivan C, Mokhlis HA, Bayraktar E, Kahraman N, Karakas D, Karamil S, Kabil NN, Kanlikilicer P, Aslan B, Tamer L, Wang Z, Cristini V, Lopez-Berestein G, Calin G, Ozpolat B. ncRNA therapy with miRNA-22-3p suppresses the growth of triple-negative breast cancer. Mol Ther Nucleic Acids. 2021 Mar 05; 23:930-943. PMID: 33614241; PMCID: PMC7868999.
      Citations: 4     
    33. Soylu H, Kirca M, Avci S, Ozpolat B, Ustunel I. Antiandrogen abiraterone and docetaxel treatments affect Notch1, Jagged1 and Hes1 expressions in metastatic prostate cancer cells. Exp Mol Pathol. 2021 04; 119:104607. PMID: 33482170.
      Citations: 1     Fields:    Translation:HumansCells
    34. Hamurcu Z, Delibasi N, Nurdinov N, Ozpolat B, ?nal TD, ?inar V, G?ler A, G?k?e S. Thymoquinone Inhibits Proliferation and Migration of MDA-MB-231 Triple Negative Breast Cancer Cells by Suppressing Autophagy, Beclin-1 and LC3. Anticancer Agents Med Chem. 2021; 21(3):355-364. PMID: 32767958.
      Citations: 4     Fields:    Translation:HumansCells
    35. Caner A, Asik E, Ozpolat B. SRC Signaling in Cancer and Tumor Microenvironment. Adv Exp Med Biol. 2021; 1270:57-71. PMID: 33123993.
      Citations: 5     Fields:    Translation:HumansCells
    36. Borahay MA, Vincent KL, Motamedi M, Tekedereli I, Salama SA, Ozpolat B, Kilic GS. Liposomal 2-Methoxyestradiol Nanoparticles for Treatment of Uterine Leiomyoma in a Patient-Derived Xenograft Mouse Model. Reprod Sci. 2021 01; 28(1):271-277. PMID: 32632769; PMCID: PMC7785630.
      Citations: 3     Fields:    Translation:HumansAnimals
    37. Karakas D, Ozpolat B. Eukaryotic elongation factor-2 kinase (eEF2K) signaling in tumor and microenvironment as a novel molecular target. J Mol Med (Berl). 2020 06; 98(6):775-787. PMID: 32377852.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    38. Comert Onder F, Sagbas Suner S, Sahiner N, Ay M, Ozpolat B. Delivery of Small Molecule EF2 Kinase Inhibitor for Breast and Pancreatic Cancer Cells Using Hyaluronic Acid Based Nanogels. Pharm Res. 2020 Mar 04; 37(3):63. PMID: 32133571.
      Citations: 1     Fields:    Translation:HumansCells
    39. Comert Onder F, Durdagi S, Sahin K, Ozpolat B, Ay M. Design, Synthesis, and Molecular Modeling Studies of Novel Coumarin Carboxamide Derivatives as eEF-2K Inhibitors. J Chem Inf Model. 2020 03 23; 60(3):1766-1778. PMID: 32027127.
      Citations: 3     Fields:    Translation:Humans
    40. Kanlikilicer P, Bayraktar R, Denizli M, Rashed MH, Ivan C, Aslan B, Mitra R, Karagoz K, Bayraktar E, Zhang X, Rodriguez-Aguayo C, El-Arabey AA, Kahraman N, Baydogan S, Ozkayar O, Gatza ML, Ozpolat B, Calin GA, Sood AK, Lopez-Berestein G. Corrigendum to 'Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer' [EBioMedicine 38 (2018) 100-112]. EBioMedicine. 2020 Feb; 52:102630. PMID: 31972470; PMCID: PMC6974767.
      Citations: 2     Fields:    
    41. El-Arabey AA, Denizli M, Kanlikilicer P, Bayraktar R, Ivan C, Rashed M, Kabil N, Ozpolat B, Calin GA, Salama SA, Abd-Allah AR, Sood AK, Lopez-Berestein G. GATA3 as a master regulator for interactions of tumor-associated macrophages with high-grade serous ovarian carcinoma. Cell Signal. 2020 04; 68:109539. PMID: 31935430.
      Citations: 23     Fields:    Translation:HumansCells
    42. Shao L, Kahraman N, Yan G, Wang J, Ozpolat B, Ittmann M. Targeting the TMPRSS2/ERG fusion mRNA using liposomal nanovectors enhances docetaxel treatment in prostate cancer. Prostate. 2020 01; 80(1):65-73. PMID: 31614005; PMCID: PMC6925833.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    43. Butner JD, Fuentes D, Ozpolat B, Calin GA, Zhou X, Lowengrub J, Cristini V, Wang Z. A Multiscale Agent-Based Model of Ductal Carcinoma In Situ. IEEE Trans Biomed Eng. 2020 05; 67(5):1450-1461. PMID: 31603768; PMCID: PMC8445608.
      Citations: 9     Fields:    Translation:HumansCells
    44. Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. 2020 01; 39(4):801-813. PMID: 31554935; PMCID: PMC6976521.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    45. Asik E, Caner A, Kahraman N, Guray T, Albarracin C, Pataer A, Ozpolat B, Akpinar Y, Volkan M, Arun B. EF2-kinase targeted cobalt-ferrite siRNA-nanotherapy suppresses BRCA1-mutated breast cancer. Nanomedicine (Lond). 2019 09; 14(17):2315-2338. PMID: 31432749.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    46. Tesikova M, Zeynep Nenseth H, Akkus E, Jin Y, Koc D, Kuzu OF, Pradhan M, Kahraman N, Mokhlis HM, Ozpolat B, Banerjee PP, Uren A, Fazli L, Rennie PS, Jin Y, Saatcioglu F, P?llmann N, Livg?rd M, Sikkeland J, Danielsen HE. Regulation of the unfolded protein response through ATF4 and FAM129A in prostate cancer. Oncogene. 2019 08; 38(35):6301-6318. PMID: 31312022.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    47. Sinha KM, Bagheri-Yarmand R, Lahiri S, Lu Y, Zhang M, Amra S, Rizvi Y, Wan X, Navone N, Ozpolat B, Logothetis C, Gagel RF, Huard J. Oncogenic and osteolytic functions of histone demethylase NO66 in castration-resistant prostate cancer. Oncogene. 2019 06; 38(25):5038-5049. PMID: 30858546.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    48. Hamurcu Z, Delibasi N, Sener EF, Nurdinov N, Taheri S, Donmez-Altuntas H, Canatan H, Ozpolat B, Nalbantoglu U, Tasci B, ?zkul Y. FOXM1 plays a role in autophagy by transcriptionally regulating Beclin-1 and LC3 genes in human triple-negative breast cancer cells. J Mol Med (Berl). 2019 04; 97(4):491-508. PMID: 30729279.
      Citations: 10     Fields:    Translation:HumansCells
    49. Gurbuz N, Ozpolat B. MicroRNA-based Targeted Therapeutics in Pancreatic Cancer. Anticancer Res. 2019 Feb; 39(2):529-532. PMID: 30711926.
      Citations: 10     Fields:    Translation:HumansAnimals
    50. Sahin K, Yenice E, Bilir B, Orhan C, Tuzcu M, Sahin N, Ozercan IH, Kabil N, Ozpolat B, Kucuk O. Genistein Prevents Development of Spontaneous Ovarian Cancer and Inhibits Tumor Growth in Hen Model. Cancer Prev Res (Phila). 2019 03; 12(3):135-146. PMID: 30651293.
      Citations: 10     Fields:    Translation:Animals
    51. Rodriguez-Aguayo C, Bayraktar E, Ivan C, Aslan B, Mai J, He G, Mangala LS, Jiang D, Nagaraja AS, Ozpolat B, Ferrari M, Mitra R, Siddik ZH, Shen H, Yang X, Sood AK, Lopez-Berestein G, Chavez-Reyes A. PTGER3 induces ovary tumorigenesis and confers resistance to cisplatin therapy through up-regulation Ras-MAPK/Erk-ETS1-ELK1/CFTR1 axis. EBioMedicine. 2019 Feb; 40:290-304. PMID: 30655206; PMCID: PMC6411965.
      Citations: 13     Fields:    Translation:HumansCells
    52. Sagbas Suner S, Ari B, Onder FC, Ozpolat B, Ay M, Sahiner N. Hyaluronic acid and hyaluronic acid: Sucrose nanogels for hydrophobic cancer drug delivery. Int J Biol Macromol. 2019 Apr 01; 126:1150-1157. PMID: 30625351.
      Citations: 10     Fields:    Translation:Humans
    53. Tekedereli I, Akar U, Alpay SN, Lopez-Berestein G, Ozpolat B. Autophagy is Required to Regulate Mitochondria Renewal, Cell Attachment, and All-trans-Retinoic Acid-Induced Differentiation in NB4 Acute Promyelocytic Leukemia Cells. J Environ Pathol Toxicol Oncol. 2019; 38(1):13-20. PMID: 30806286.
      Citations: 3     Fields:    Translation:HumansCells
    54. Mokhlis HA, Bayraktar R, Kabil NN, Caner A, Kahraman N, Rodriguez-Aguayo C, Zambalde EP, Sheng J, Kanlikilicer P, Abdel Aziz AAH, Abdelghany TM, Ashour AA, Wong S, Gatza ML, Calin GA, Lopez-Berestein G, Ozpolat B, Karagoz K. The Modulatory Role of MicroRNA-873 in the Progression of KRAS-Driven Cancers. Mol Ther Nucleic Acids. 2019 Mar 01; 14:301-317. PMID: 30654191; PMCID: PMC6348737.
      Citations: 11     
    55. Aslan M, Shahbazi R, Ulubayram K, Ozpolat B. Targeted Therapies for Pancreatic Cancer and Hurdles Ahead. Anticancer Res. 2018 Dec; 38(12):6591-6606. PMID: 30504367.
      Citations: 26     Fields:    Translation:HumansCells
    56. Kanlikilicer P, Bayraktar R, Denizli M, Rashed MH, Ivan C, Aslan B, Mitra R, Karagoz K, Bayraktar E, Zhang X, Rodriguez-Aguayo C, El-Arabey AA, Kahraman N, Baydogan S, Ozkayar O, Gatza ML, Ozpolat B, Calin GA, Sood AK, Lopez-Berestein G. Exosomal miRNA confers chemo resistance via targeting Cav1/p-gp/M2-type macrophage axis in ovarian cancer. EBioMedicine. 2018 Dec; 38:100-112. PMID: 30487062; PMCID: PMC6306310.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    57. Bircan HA, Gurbuz N, Pataer A, Caner A, Kahraman N, Bayraktar E, Bayraktar R, Erdogan MA, Kabil N, Ozpolat B. Elongation factor-2 kinase (eEF-2K) expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer. Lung Cancer. 2018 10; 124:31-39. PMID: 30268477.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    58. Kabil N, Bayraktar R, Kahraman N, Mokhlis HA, Calin GA, Lopez-Berestein G, Ozpolat B. Thymoquinone inhibits cell proliferation, migration, and invasion by regulating the elongation factor 2 kinase (eEF-2K) signaling axis in triple-negative breast cancer. Breast Cancer Res Treat. 2018 Oct; 171(3):593-605. PMID: 29971628.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    59. Bayraktar R, Ivan C, Bayraktar E, Kanlikilicer P, Kabil NN, Kahraman N, Mokhlis HA, Karakas D, Rodriguez-Aguayo C, Arslan A, Sheng J, Wong S, Lopez-Berestein G, Calin GA, Ozpolat B. Dual Suppressive Effect of miR-34a on the FOXM1/eEF2-Kinase Axis Regulates Triple-Negative Breast Cancer Growth and Invasion. Clin Cancer Res. 2018 09 01; 24(17):4225-4241. PMID: 29748184.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    60. Sahin K, Yenice E, Tuzcu M, Orhan C, Mizrak C, Ozercan IH, Sahin N, Yilmaz B, Bilir B, Ozpolat B, Kucuk O. Lycopene Protects Against Spontaneous Ovarian Cancer Formation in Laying Hens. J Cancer Prev. 2018 Mar; 23(1):25-36. PMID: 29629346; PMCID: PMC5886492.
      Citations: 10     
    61. Hamurcu Z, Delibasi N, Sener EF, Canatan H, Ozpolat B, Ge?ene S, D?nmez-Altuntas H, ?zkul Y. Targeting LC3 and Beclin-1 autophagy genes suppresses proliferation, survival, migration and invasion by inhibition of Cyclin-D1 and uPAR/Integrin ?1/ Src signaling in triple negative breast cancer cells. J Cancer Res Clin Oncol. 2018 Mar; 144(3):415-430. PMID: 29288363.
      Citations: 35     Fields:    Translation:HumansCells
    62. Cevatemre B, Erkisa M, Aztopal N, Karakas D, Alper P, Tsimplouli C, Sereti E, Dimas K, Armutak EII, Gurevin EG, Uvez A, Mori M, Berardozzi S, Ingallina C, D'Acquarica I, Botta B, Ozpolat B, Ulukaya E. A promising natural product, pristimerin, results in cytotoxicity against breast cancer stem cells in vitro and xenografts in vivo through apoptosis and an incomplete autopaghy in breast cancer. Pharmacol Res. 2018 03; 129:500-514. PMID: 29197639.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    63. Sahin K, Orhan C, Tuzcu M, Sahin N, Tastan H, Kahraman N, Kucuk O, Ozpolat B, ?zercan IH, G?ler O. Chemopreventive and Antitumor Efficacy of Curcumin in a Spontaneously Developing Hen Ovarian Cancer Model. Cancer Prev Res (Phila). 2018 01; 11(1):59-67. PMID: 29089332.
      Citations: 14     Fields:    Translation:AnimalsCells
    64. Rodriguez-Aguayo C, Monroig PDC, Redis RS, Bayraktar E, Almeida MI, Ivan C, Fuentes-Mattei E, Rashed MH, Chavez-Reyes A, Ozpolat B, Mitra R, Sood AK, Calin GA, Lopez-Berestein G. Regulation of hnRNPA1 by microRNAs controls the miR-18a-K-RAS axis in chemotherapy-resistant ovarian cancer. Cell Discov. 2017; 3:17029. PMID: 28904816; PMCID: PMC5594916.
      Citations: 20     
    65. Shahbazi R, Asik E, Kahraman N, Turk M, Ozpolat B, Ulubayram K. Modified gold-based siRNA nanotherapeutics for targeted therapy of triple-negative breast cancer. Nanomedicine (Lond). 2017 Aug; 12(16):1961-1973. PMID: 28745127.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    66. Kanlikilicer P, Ozpolat B, Aslan B, Bayraktar R, Gurbuz N, Rodriguez-Aguayo C, Bayraktar E, Denizli M, Gonzalez-Villasana V, Ivan C, Lokesh GLR, Amero P, Catuogno S, Haemmerle M, Wu SY, Mitra R, Gorenstein DG, Volk DE, de Franciscis V, Sood AK, Lopez-Berestein G. Therapeutic Targeting of AXL Receptor Tyrosine Kinase Inhibits Tumor Growth and Intraperitoneal Metastasis in Ovarian Cancer Models. Mol Ther Nucleic Acids. 2017 Dec 15; 9:251-262. PMID: 29246304; PMCID: PMC5675720.
      Citations: 29     
    67. Ercan G, Karlitepe A, Ozpolat B. Pancreatic Cancer Stem Cells and Therapeutic Approaches. Anticancer Res. 2017 06; 37(6):2761-2775. PMID: 28551612.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    68. Hamurcu Z, Kahraman N, Ashour A, Ozpolat B. FOXM1 transcriptionally regulates expression of integrin ?1 in triple-negative breast cancer. Breast Cancer Res Treat. 2017 Jun; 163(3):485-493. PMID: 28361350.
      Citations: 10     Fields:    Translation:HumansCells
    69. Rashed MH, Kanlikilicer P, Rodriguez-Aguayo C, Pichler M, Bayraktar R, Bayraktar E, Ivan C, Filant J, Aslan B, Denizli M, Mitra R, Ozpolat B, Calin GA, Sood AK, Abd-Ellah MF, Helal GK, Berestein GL, Silva A. Exosomal miR-940 maintains SRC-mediated oncogenic activity in cancer cells: a possible role for exosomal disposal of tumor suppressor miRNAs. Oncotarget. 2017 Mar 21; 8(12):20145-20164. PMID: 28423620; PMCID: PMC5386751.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    70. Bayraktar R, Pichler M, Kanlikilicer P, Ivan C, Bayraktar E, Kahraman N, Aslan B, Oguztuzun S, Ulasli M, Arslan A, Calin G, Lopez-Berestein G, Ozpolat B. MicroRNA 603 acts as a tumor suppressor and inhibits triple-negative breast cancer tumorigenesis by targeting elongation factor 2 kinase. Oncotarget. 2017 Feb 14; 8(7):11641-11658. PMID: 28036267; PMCID: PMC5355293.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    71. Sok SP, Arshad NM, Azmi MN, Awang K, Ozpolat B, Hasima Nagoor N. The apoptotic effect of 1'S-1'-Acetoxychavicol Acetate (ACA) enhanced by inhibition of non-canonical autophagy in human non-small cell lung cancer cells. PLoS One. 2017; 12(2):e0171329. PMID: 28158287; PMCID: PMC5291426.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    72. Kanlikilicer P, Rashed MH, Bayraktar R, Mitra R, Ivan C, Aslan B, Zhang X, Filant J, Silva AM, Rodriguez-Aguayo C, Bayraktar E, Pichler M, Ozpolat B, Calin GA, Sood AK, Lopez-Berestein G. Ubiquitous Release of Exosomal Tumor Suppressor miR-6126 from Ovarian Cancer Cells. Cancer Res. 2016 12 15; 76(24):7194-7207. PMID: 27742688; PMCID: PMC5901763.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    73. Gurbuz N, Asoglu MR, Ashour AA, Salama S, Kilic GS, Ozpolat B. A selective serotonin 5-HT1B receptor inhibition suppresses cells proliferation and induces apoptosis in human uterine leiomyoma cells. Eur J Obstet Gynecol Reprod Biol. 2016 Nov; 206:114-119. PMID: 27669395.
      Citations: 3     Fields:    Translation:HumansCells
    74. Shahbazi R, Ozpolat B, Ulubayram K. Oligonucleotide-based theranostic nanoparticles in cancer therapy. Nanomedicine (Lond). 2016 05; 11(10):1287-308. PMID: 27102380; PMCID: PMC5563863.
      Citations: 4     Fields:    Translation:HumansAnimals
    75. Hamurcu Z, Ashour A, Kahraman N, Ozpolat B. FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells. Oncotarget. 2016 Mar 29; 7(13):16619-35. PMID: 26918606; PMCID: PMC4941339.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    76. Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, Agnello M, Agostinis P, Aguilar PV, Aguirre-Ghiso J, Airoldi EM, Akematsu T, Akporiaye ET, Al-Rubeai M, Albanese C, Albani D, Albert ML, Aldudo J, Alirezaei M, Alloza I, Almasan A, Alnemri ES, Altan-Bonnet N, Altieri DC, Alvarez S, Alvarez-Erviti L, Alves S, Amadoro G, Amano A, Amantini C, Ambrosio S, Amelio I, Amer AO, Amessou M, Amon A, An Z, Anania FA, Andersen SU, Andley UP, Andreadi CK, Anel A, Ann DK, Anoopkumar-Dukie S, Antonioli M, Aoki H, Apostolova N, Aquila S, Aquilano K, Araki K, Arama E, Aranda A, Araya J, Arcaro A, Arias E, Arimoto H, Ariosa AR, Armstrong JL, Arnould T, Arsov I, Asanuma K, Askanas V, Asselin E, Atarashi R, Atherton SS, Atkin JD, Attardi LD, Auberger P, Auburger G, Aurelian L, Autelli R, Avagliano L, Avantaggiati ML, Avrahami L, Awale S, Azad N, Bachetti T, Backer JM, Bae DH, Bae JS, Bae ON, Bae SH, Baehrecke EH, Baek SH, Bagniewska-Zadworna A, Bai H, Bai J, Bai XY, Balaji KN, Balduini W, Ballabio A, Balzan R, Banerjee R, Bao H, Barrachina MD, Barreiro E, Bartel B, Bassham DC, Bassi MT, Bast RC, Basu A, Batista MT, Battino M, Bauckman K, Baumgarner BL, Bayer KU, Beale R, Beck GR, Beckham JD, Bednarski PJ, Begley TJ, Behl C, Behrends C, Behrens GM, Behrns KE, Bejarano E, Belaid A, Belleudi F, Berchem G, Bergamaschi D, Bergami M, Berkhout B, Berliocchi L, Bernassola F, Bertolotti A, Bess AS, Bettuzzi S, Bhalla S, Bhattacharyya S, Bhutia SK, Biagosch C, Bingol B, Bird SW, Bjedov I, Blackstone C, Blanc L, Blanco GA, Blomhoff HK, Boada-Romero E, Boes M, Boesze-Battaglia K, Boise LH, Bolino A, Bonaldo P, Bordi M, Boulton ME, Bouret SG, Bozhkov PV, Brady N, Braga VM, Brancolini C, Brennan LA, Bresnick EH, Brest P, Bridges D, Brini M, Brodin B, Brookes PS, Brown EJ, Brown K, Broxmeyer HE, Brumell JH, Brunetti-Pierri N, Bryson-Richardson RJ, Buch S, Buchan AM, Budak H, Bulavin DV, Bultman SJ, Bultynck G, Bumbasirevic V, Burke RE, Burmeister M, Caberlotto L, Cadwell K, Cahova M, Cai D, Cai J, Cai Q, Calatayud S, Campanella M, Campbell GR, Campbell M, Campello S, Caniggia I, Cantoni L, Cao L, Caplan AB, Caraglia M, Cardinali C, Cardoso SM, Carew JS, Carleton LA, Carlin CR, Carloni S, Carmona-Gutierrez D, Carneiro LA, Carnevali O, Carra S, Carroll B, Casas J, Cassinelli G, Castets P, Castro-Obregon S, Cavallini G, Ceccherini I, Cecconi F, Cederbaum AI, Cervia D, Cetrullo S, Chae HJ, Chagin AS, Chai CY, Chakrabarti G, Chamilos G, Chan EY, Chan MT, Chandra D, Chandra P, Chang CP, Chang RC, Chang TY, Chatham JC, Chatterjee S, Chauhan S, Che Y, Cheetham ME, Cheluvappa R, Chen CJ, Chen G, Chen GC, Chen G, Chen H, Chen JW, Chen JK, Chen M, Chen M, Chen P, Chen Q, Chen Q, Chen SD, Chen S, Chen SS, Chen W, Chen WJ, Chen WQ, Chen W, Chen X, Chen YH, Chen YG, Chen Y, Chen Y, Chen Y, Chen YJ, Chen YQ, Chen Y, Chen Z, Chen Z, Cheng A, Cheng CH, Cheng H, Cheong H, Cherry S, Chesney J, Cheung CH, Chi HC, Chi SG, Chiacchiera F, Chiang HL, Chiarelli R, Chiariello M, Chieppa M, Chin LS, Chiong M, Chiu GN, Cho DH, Cho SG, Cho WC, Cho YY, Cho YS, Choi AM, Choi EJ, Choi EK, Choi J, Choi ME, Choi SI, Chou TF, Chouaib S, Choubey D, Choubey V, Chow KC, Chu CT, Chuang TH, Chun T, Chung H, Chung T, Chung YL, Chwae YJ, Cianfanelli V, Ciarcia R, Ciechomska IA, Ciriolo MR, Cirone M, Claerhout S, Clague MJ, Clarke PG, Clarke R, Clementi E, Cnop M, Cocco T, Cohen EE, Colecchia D, Coletto L, Comincini S, Condello M, Cook KL, Coombs GH, Cooper CD, Cooper JM, Coppens I, Corasaniti MT, Corazzari M, Corbalan R, Corcelle-Termeau E, Cordero MD, Corti O, Cossarizza A, Costelli P, Costes S, Cotman SL, Coto-Montes A, Cottet S, Covey LR, Cowart LA, Cox JS, Coxon FP, Coyne CB, Cragg MS, Craven RJ, Crepaldi T, Criollo A, Crippa V, Cruz MT, Cuervo AM, Cuezva JM, Cui T, Cutillas PR, Czaja MJ, Czyzyk-Krzeska MF, Dagda RK, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016; 12(1):1-222. PMID: 26799652; PMCID: PMC4835977.
      Citations: 2567     Fields:    Translation:HumansAnimals
    77. Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK, Armaiz-Pe?a GN. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015 Nov 09; 28(5):610-622. PMID: 26481148; PMCID: PMC4643364.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    78. Ozpolat B, Benbrook DM. Targeting autophagy in cancer management - strategies and developments. Cancer Manag Res. 2015; 7:291-9. PMID: 26392787; PMCID: PMC4573074.
      Citations: 50     
    79. Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P, Fuentes-Mattei E, Kahraman N, Pradeep S, Ozpolat B, Tucker S, Hung MC, Baggerly K, Bartholomeusz G, Calin G, Sood AK, Lopez-Berestein G. The ZNF304-integrin axis protects against anoikis in cancer. Nat Commun. 2015 Jun 17; 6:7351. PMID: 26081979; PMCID: PMC4830335.
      Citations: 29     Fields:    Translation:HumansCells
    80. Arun B, Akar U, Gutierrez-Barrera AM, Hortobagyi GN, Ozpolat B. The PARP inhibitor AZD2281 (Olaparib) induces autophagy/mitophagy in BRCA1 and BRCA2 mutant breast cancer cells. Int J Oncol. 2015 Jul; 47(1):262-8. PMID: 25975349; PMCID: PMC6904111.
      Citations: 24     Fields:    Translation:HumansCells
    81. Olmez I, Shen W, McDonald H, Ozpolat B. Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth. J Cell Mol Med. 2015 Jun; 19(6):1262-72. PMID: 25787115; PMCID: PMC4459842.
      Citations: 25     Fields:    Translation:HumansCells
    82. Jin Y, Wang L, Qu S, Sheng X, Kristian A, Yuca E, Tekedereli I, Gorgulu K, Alpay N, Sood A, Lopez-Berestein G, Fazli L, Rennie P, Ozpolat B, Saatcioglu F, M?landsmo GM, P?llmann N, Risberg B, W?hre H, Danielsen HE. STAMP2 increases oxidative stress and is critical for prostate cancer. EMBO Mol Med. 2015 Mar; 7(3):315-31. PMID: 25680860; PMCID: PMC4364948.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    83. Ozcan G, Ozpolat B, Coleman RL, Sood AK, Lopez-Berestein G. Preclinical and clinical development of siRNA-based therapeutics. Adv Drug Deliv Rev. 2015 Jun 29; 87:108-19. PMID: 25666164; PMCID: PMC4504743.
      Citations: 132     Fields:    Translation:HumansAnimals
    84. Gonzalez-Villasana V, Fuentes-Mattei E, Ivan C, Dalton HJ, Rodriguez-Aguayo C, Fernandez-de Thomas RJ, Aslan B, Del C Monroig P, Velazquez-Torres G, Previs RA, Pradeep S, Kahraman N, Wang H, Kanlikilicer P, Ozpolat B, Calin G, Sood AK, Lopez-Berestein G. Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer. Clin Cancer Res. 2015 May 01; 21(9):2127-37. PMID: 25595279; PMCID: PMC4417466.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    85. Gurbuz N, Ashour AA, Alpay SN, Ozpolat B. Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PLoS One. 2014; 9(9):e110067. PMID: 25268648; PMCID: PMC4182508.
      Citations: 7     Fields:    Translation:HumansCells
    86. Ashour AA, Gurbuz N, Alpay SN, Abdel-Aziz AA, Mansour AM, Huo L, Ozpolat B. Elongation factor-2 kinase regulates TG2/?1 integrin/Src/uPAR pathway and epithelial-mesenchymal transition mediating pancreatic cancer cells invasion. J Cell Mol Med. 2014 Nov; 18(11):2235-51. PMID: 25215932; PMCID: PMC4224557.
      Citations: 28     Fields:    Translation:HumansCells
    87. Gonzalez-Villasana V, Rodriguez-Aguayo C, Arumugam T, Cruz-Monserrate Z, Fuentes-Mattei E, Deng D, Hwang RF, Wang H, Ivan C, Garza RJ, Cohen E, Gao H, Armaiz-Pena GN, Del C Monroig-Bosque P, Philip B, Rashed MH, Aslan B, Erdogan MA, Gutierrez-Puente Y, Ozpolat B, Reuben JM, Sood AK, Logsdon C, Lopez-Berestein G. Bisphosphonates inhibit stellate cell activity and enhance antitumor effects of nanoparticle albumin-bound paclitaxel in pancreatic ductal adenocarcinoma. Mol Cancer Ther. 2014 Nov; 13(11):2583-94. PMID: 25193509; PMCID: PMC4221441.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    88. Gurbuz N, Ashour AA, Alpay SN, Ozpolat B. Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PLoS One. 2014; 9(8):e105245. PMID: 25170871; PMCID: PMC4149367.
      Citations: 7     Fields:    Translation:HumansCells
    89. Tucker SL, Gharpure K, Herbrich SM, Unruh AK, Nick AM, Crane EK, Coleman RL, Guenthoer J, Dalton HJ, Wu SY, Rupaimoole R, Lopez-Berestein G, Ozpolat B, Ivan C, Hu W, Baggerly KA, Sood AK. Molecular biomarkers of residual disease after surgical debulking of high-grade serous ovarian cancer. Clin Cancer Res. 2014 Jun 15; 20(12):3280-8. PMID: 24756370; PMCID: PMC4062703.
      Citations: 34     Fields:    Translation:Humans
    90. Wen Y, Zand B, Ozpolat B, Szczepanski MJ, Lu C, Yuca E, Carroll AR, Alpay N, Bartholomeusz C, Tekedereli I, Kang Y, Rupaimoole R, Pecot CV, Dalton HJ, Hernandez A, Lokshin A, Lutgendorf SK, Liu J, Hittelman WN, Chen WY, Lopez-Berestein G, Szajnik M, Ueno NT, Coleman RL, Sood AK. Antagonism of tumoral prolactin receptor promotes autophagy-related cell death. Cell Rep. 2014 Apr 24; 7(2):488-500. PMID: 24703838; PMCID: PMC4038960.
      Citations: 26     Fields:    Translation:HumansCells
    91. Ashour AA, Abdel-Aziz AA, Mansour AM, Alpay SN, Huo L, Ozpolat B. Targeting elongation factor-2 kinase (eEF-2K) induces apoptosis in human pancreatic cancer cells. Apoptosis. 2014 Jan; 19(1):241-58. PMID: 24193916.
      Citations: 34     Fields:    Translation:HumansCells
    92. Ozpolat B, Sood AK, Lopez-Berestein G. Liposomal siRNA nanocarriers for cancer therapy. Adv Drug Deliv Rev. 2014 Feb; 66:110-6. PMID: 24384374; PMCID: PMC4527165.
      Citations: 98     Fields:    Translation:HumansAnimals
    93. Aslan B, Ozpolat B, Sood AK, Lopez-Berestein G. Nanotechnology in cancer therapy. J Drug Target. 2013 Dec; 21(10):904-13. PMID: 24079419; PMCID: PMC4057038.
      Citations: 35     Fields:    Translation:HumansAnimals
    94. Devkota AK, Warthaka M, Edupuganti R, Tavares CD, Johnson WH, Ozpolat B, Cho EJ, Dalby KN. High-throughput screens for eEF-2 kinase. J Biomol Screen. 2014 Mar; 19(3):445-52. PMID: 24078616.
      Citations: 9     Fields:    
    95. Tekedereli I, Alpay SN, Akar U, Yuca E, Ayugo-Rodriguez C, Han HD, Sood AK, Lopez-Berestein G, Ozpolat B. Therapeutic Silencing of Bcl-2 by Systemically Administered siRNA Nanotherapeutics Inhibits Tumor Growth by Autophagy and Apoptosis and Enhances the Efficacy of Chemotherapy in Orthotopic Xenograft Models of ER (-) and ER (+) Breast Cancer. Mol Ther Nucleic Acids. 2013 Sep 10; 2:e121. PMID: 24022053; PMCID: PMC4028016.
      Citations: 31     
    96. Jin Y, Qu S, Tesikova M, Wang L, Kristian A, Kong H, Zhang T, Teixeira MR, Yuca E, Tekedereli I, Gorgulu K, Alpay N, Sood AK, Lopez-Berestein G, Ozpolat B, Saatcioglu F, M?landsmo GM, Jer?nimo C, Danielsen HE. Molecular circuit involving KLK4 integrates androgen and mTOR signaling in prostate cancer. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):E2572-81. PMID: 23798432; PMCID: PMC3710885.
      Citations: 35     Fields:    Translation:HumansCells
    97. Borahay MA, Lu F, Ozpolat B, Tekedereli I, Gurates B, Karipcin S, Kilic GS. Mullerian inhibiting substance suppresses proliferation and induces apoptosis and autophagy in endometriosis cells in vitro. ISRN Obstet Gynecol. 2013; 2013:361489. PMID: 23853725; PMCID: PMC3703732.
      Citations: 10     
    98. Yenigun VB, Ozpolat B, Kose GT. Response of CD44+/CD24-/low breast cancer stem/progenitor cells to tamoxifen- and doxorubicin-induced autophagy. Int J Mol Med. 2013 Jun; 31(6):1477-83. PMID: 23589132.
      Citations: 8     Fields:    Translation:HumansCells
    99. Shao L, Tekedereli I, Wang J, Yuca E, Tsang S, Sood A, Lopez-Berestein G, Ozpolat B, Ittmann M. Highly specific targeting of the TMPRSS2/ERG fusion gene using liposomal nanovectors. Clin Cancer Res. 2012 Dec 15; 18(24):6648-57. PMID: 23052253; PMCID: PMC3525716.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    100. Tekedereli I, Alpay SN, Tavares CD, Cobanoglu ZE, Kaoud TS, Sahin I, Sood AK, Lopez-Berestein G, Dalby KN, Ozpolat B. Targeted silencing of elongation factor 2 kinase suppresses growth and sensitizes tumors to doxorubicin in an orthotopic model of breast cancer. PLoS One. 2012; 7(7):e41171. PMID: 22911754; PMCID: PMC3401164.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    101. Ozpolat B, Akar U, Tekedereli I, Alpay SN, Barria M, Gezgen B, Zhang N, Coombes K, Kornblau S, Lopez-Berestein G. PKCd Regulates Translation Initiation through PKR and eIF2a in Response to Retinoic Acid in Acute Myeloid Leukemia Cells. Leuk Res Treatment. 2012; 2012:482905. PMID: 23259068; PMCID: PMC3505929.
      Citations: 4     
    102. Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, Al-Younes HM, Al-Zeer MA, Albert ML, Albin RL, Alegre-Abarrategui J, Aleo MF, Alirezaei M, Almasan A, Almonte-Becerril M, Amano A, Amaravadi R, Amarnath S, Amer AO, Andrieu-Abadie N, Anantharam V, Ann DK, Anoopkumar-Dukie S, Aoki H, Apostolova N, Arancia G, Aris JP, Asanuma K, Asare NY, Ashida H, Askanas V, Askew DS, Auberger P, Baba M, Backues SK, Baehrecke EH, Bahr BA, Bai XY, Bailly Y, Baiocchi R, Baldini G, Balduini W, Ballabio A, Bamber BA, Bampton ET, Bartholomew CR, Bassham DC, Bast RC, Batoko H, Bay BH, Beau I, Begley TJ, Behl C, Behrends C, Bekri S, Bellaire B, Bendall LJ, Benetti L, Berliocchi L, Bernardi H, Bernassola F, Bhatia-Kissova I, Bi X, Biard-Piechaczyk M, Blum JS, Boise LH, Bonaldo P, Boone DL, Bornhauser BC, Bortoluci KR, Bossis I, Bourquin JP, Boya P, Bozhkov PV, Brady NR, Brancolini C, Brech A, Brenman JE, Brennand A, Bresnick EH, Brest P, Bridges D, Bristol ML, Brookes PS, Brown EJ, Brumell JH, Brunetti-Pierri N, Brunk UT, Bulman DE, Bultman SJ, Bultynck G, Burbulla LF, Bursch W, Butchar JP, Buzgariu W, Bydlowski SP, Cadwell K, Cai D, Cai J, Cai Q, Calabretta B, Calvo-Garrido J, Camougrand N, Campanella M, Campos-Salinas J, Candi E, Cao L, Caplan AB, Carding SR, Cardoso SM, Carew JS, Carlin CR, Carmignac V, Carneiro LA, Carra S, Caruso RA, Casari G, Casas C, Castino R, Cebollero E, Cecconi F, Celli J, Chaachouay H, Chae HJ, Chai CY, Chan DC, Chan EY, Chang RC, Che CM, Chen CC, Chen GC, Chen GQ, Chen M, Chen Q, Chen SS, Chen W, Chen X, Chen X, Chen X, Chen YG, Chen Y, Chen Y, Chen YJ, Chen Z, Cheng A, Cheng CH, Cheng Y, Cheong H, Cheong JH, Cherry S, Chess-Williams R, Cheung ZH, Chevet E, Chiang HL, Chiarelli R, Chiba T, Chin LS, Chiou SH, Chisari FV, Cho CH, Cho DH, Choi AM, Choi D, Choi KS, Choi ME, Chouaib S, Choubey D, Choubey V, Chu CT, Chuang TH, Chueh SH, Chun T, Chwae YJ, Chye ML, Ciarcia R, Ciriolo MR, Clague MJ, Clark RS, Clarke PG, Clarke R, Codogno P, Coller HA, Comincini S, Condello M, Condorelli F, Cookson MR, Coombs GH, Coppens I, Corbalan R, Cossart P, Costelli P, Costes S, Coto-Montes A, Couve E, Coxon FP, Cregg JM, Cuervo AM, Cullen JJ, Czaja MJ, D'Amelio M, Darfeuille-Michaud A, Davids LM, Davies FE, De Felici M, de Groot JF, de Haan CA, De Martino L, De Milito A, De Tata V, Debnath J, Degterev A, Dehay B, Delbridge LM, Demarchi F, Deng YZ, Dent P, Denton D, Deretic V, Desai SD, Devenish RJ, Di Gioacchino M, Di Paolo G, Di Pietro C, Diaz-Meco MT, Diaz-Nido J, Dikic I, Dinesh-Kumar SP, Ding WX, Distelhorst CW, Diwan A, Djavaheri-Mergny M, Dokudovskaya S, Dong Z, Dorsey FC, Dosenko V, Dowling JJ, Doxsey S, Drew ME, Duan Q, Duchosal MA, Duff K, Dugail I, Durbeej M, Duszenko M, Edelstein CL, Edinger AL, Egea G, Eichinger L, Eissa NT, Ekmekcioglu S, El-Deiry WS, Elazar Z, Elgendy M, Ellerby LM, Eng KE, Engelbrecht AM, Engelender S, Erenpreisa J, Escalante R, Esclatine A, Eskelinen EL, Espert L, Espina V, Fan H, Fan J, Fan QW, Fan Z, Fang S, Fang Y, Fanto M, Fanzani A, Farkas T, Faure M, Fechheimer M, Feng CG, Feng J, Feng Q, Feng Y, Feuer R, Figueiredo-Pereira ME, Fimia GM, Fingar DC, Finkbeiner S, Finkel T, Finley KD, Fiorito F, Fisher EA, Fisher PB, Flajolet M, Florez-McClure ML, Florio S, Fon EA, Fornai F, Fortunato F, Fotedar R, Fowler DH, Fox HS, Franco R, Frankel LB, Fransen M, Fueyo J, Fujii J, Fujisaki K, Fujita E, Fukuda M, Furukawa RH, Gaestel M, Gailly P, Gajewska M, Galliot B, Galy V, Ganesh S, Ganetzky B, Ganley IG, Gao FB, Gao GF, Gao J, Garcia L, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 2012 Apr; 8(4):445-544. PMID: 22966490; PMCID: PMC3404883.
      Citations: 1751     Fields:    Translation:HumansAnimals
    103. Tavares CD, O'Brien JP, Abramczyk O, Devkota AK, Shores KS, Ferguson SB, Kaoud TS, Warthaka M, Marshall KD, Keller KM, Zhang Y, Brodbelt JS, Ozpolat B, Dalby KN. Calcium/calmodulin stimulates the autophosphorylation of elongation factor 2 kinase on Thr-348 and Ser-500 to regulate its activity and calcium dependence. Biochemistry. 2012 Mar 20; 51(11):2232-45. PMID: 22329831; PMCID: PMC3401519.
      Citations: 28     Fields:    Translation:HumansCells
    104. Devkota AK, Tavares CD, Warthaka M, Abramczyk O, Marshall KD, Kaoud TS, Gorgulu K, Ozpolat B, Dalby KN. Investigating the kinetic mechanism of inhibition of elongation factor 2 kinase by NH125: evidence of a common in vitro artifact. Biochemistry. 2012 Mar 13; 51(10):2100-12. PMID: 22352903; PMCID: PMC3673019.
      Citations: 27     Fields:    Translation:HumansCells
    105. Stone RL, Nick AM, McNeish IA, Balkwill F, Han HD, Bottsford-Miller J, Rupairmoole R, Armaiz-Pena GN, Pecot CV, Coward J, Deavers MT, Vasquez HG, Urbauer D, Landen CN, Hu W, Gershenson H, Matsuo K, Shahzad MM, King ER, Tekedereli I, Ozpolat B, Ahn EH, Bond VK, Wang R, Drew AF, Gushiken F, Lamkin D, Collins K, DeGeest K, Lutgendorf SK, Chiu W, Lopez-Berestein G, Afshar-Kharghan V, Sood AK. Paraneoplastic thrombocytosis in ovarian cancer. N Engl J Med. 2012 Feb 16; 366(7):610-8. PMID: 22335738; PMCID: PMC3296780.
      Citations: 316     Fields:    Translation:HumansAnimalsCellsCTClinical Trials
    106. Nick AM, Stone RL, Armaiz-Pena G, Ozpolat B, Tekedereli I, Graybill WS, Landen CN, Villares G, Vivas-Mejia P, Bottsford-Miller J, Kim HS, Lee JS, Kim SM, Baggerly KA, Ram PT, Deavers MT, Coleman RL, Lopez-Berestein G, Sood AK. Silencing of p130cas in ovarian carcinoma: a novel mechanism for tumor cell death. J Natl Cancer Inst. 2011 Nov 02; 103(21):1596-612. PMID: 21957230; PMCID: PMC3206039.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    107. Abramczyk O, Tavares CD, Devkota AK, Ryazanov AG, Turk BE, Riggs AF, Ozpolat B, Dalby KN. Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli. Protein Expr Purif. 2011 Oct; 79(2):237-44. PMID: 21605678; PMCID: PMC3389548.
      Citations: 17     Fields:    Translation:HumansCells
    108. Akar U, Ozpolat B, Mehta K, Lopez-Berestein G, Zhang D, Ueno NT, Hortobagyi GN, Arun B. Targeting p70S6K prevented lung metastasis in a breast cancer xenograft model. Mol Cancer Ther. 2010 May; 9(5):1180-7. PMID: 20423989.
      Citations: 20     Fields:    Translation:HumansAnimals
    109. Dalby KN, Tekedereli I, Lopez-Berestein G, Ozpolat B. Targeting the prodeath and prosurvival functions of autophagy as novel therapeutic strategies in cancer. Autophagy. 2010 Apr; 6(3):322-9. PMID: 20224296; PMCID: PMC2914492.
      Citations: 202     Fields:    Translation:HumansAnimalsCells
    110. Ozpolat B, Sood AK, Lopez-Berestein G. Nanomedicine based approaches for the delivery of siRNA in cancer. J Intern Med. 2010 Jan; 267(1):44-53. PMID: 20059643.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    111. Ozpolat B, Chen X, Lopez-Berestein G, Vivas-Mej?a PE. Downregulation of the c-MYC target gene, peroxiredoxin III, contributes to arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Int J Cancer. 2009 Jul 15; 125(2):264-75. PMID: 19408305; PMCID: PMC10166086.
      Citations: 10     Fields:    Translation:HumansCells
    112. ?zpolat B. Acute promyelocytic leukemia and differentiation therapy: molecular mechanisms of differentiation, retinoic acid resistance and novel treatments. Turk J Haematol. 2009 Jun 05; 26(2):47-61. PMID: 27265273.
      Citations: 1     Fields:    
    113. Ozpolat B, Akar U, Zorrilla-Calancha I, Vivas-Mejia P, Acevedo-Alvarez M, Lopez-Berestein G. Death-associated protein 5 (DAP5/p97/NAT1) contributes to retinoic acid-induced granulocytic differentiation and arsenic trioxide-induced apoptosis in acute promyelocytic leukemia. Apoptosis. 2008 Jul; 13(7):915-28. PMID: 18491231.
      Citations: 4     Fields:    Translation:HumansCells
    114. Akar U, Chaves-Reyez A, Barria M, Tari A, Sanguino A, Kondo Y, Kondo S, Arun B, Lopez-Berestein G, Ozpolat B. Silencing of Bcl-2 expression by small interfering RNA induces autophagic cell death in MCF-7 breast cancer cells. Autophagy. 2008 Jul; 4(5):669-79. PMID: 18424910.
      Citations: 104     Fields:    Translation:HumansCells
    115. Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, Blum JS, Bredesen DE, Brodsky JL, Brumell JH, Brunk UT, Bursch W, Camougrand N, Cebollero E, Cecconi F, Chen Y, Chin LS, Choi A, Chu CT, Chung J, Clarke PG, Clark RS, Clarke SG, Cleveland JL, Codogno P, Coto-Montes A, Cregg JM, Cuervo AM, Debnath J, Demarchi F, Dennis PB, Dennis PA, Deretic V, Devenish RJ, Di Sano F, Dice JF, Difiglia M, Dinesh-Kumar S, Distelhorst CW, Djavaheri-Mergny M, Dorsey FC, Dron M, Dunn WA, Duszenko M, Eissa NT, Elazar Z, Esclatine A, Eskelinen EL, Finley KD, Fueyo J, Fujisaki K, Galliot B, Gao FB, Gewirtz DA, Gibson SB, Gohla A, Goldberg AL, Gonzalez R, Gorski S, Gottlieb RA, He YW, Heidenreich K, Hill JA, Hu X, Huang WP, Iwasaki A, Jackson WT, Jiang X, Jin S, Johansen T, Jung JU, Kadowaki M, Kang C, Kelekar A, Kessel DH, Kiel JA, Kim HP, Kimchi A, Kinsella TJ, Kiselyov K, Kitamoto K, Knecht E, Komatsu M, Kominami E, Kondo S, Kroemer G, Kuan CY, Kumar R, Kundu M, Landry J, Laporte M, Le W, Lei HY, Lenardo MJ, Levine B, Lieberman A, Lim KL, Lin FC, Liou W, Liu LF, Lopez-Berestein G, Lu B, Macleod KF, Malorni W, Martinet W, Matsuoka K, Mautner J, Meijer AJ, Michels P, Miotto G, Mistiaen WP, Mizushima N, Mograbi B, Monastyrska I, Moore MN, Moreira PI, Moriyasu Y, Motyl T, Murphy LO, Naqvi NI, Neufeld TP, Nishino I, Nixon RA, Noda T, Ogawa M, Oleinick NL, Olsen LJ, Ozpolat B, Paglin S, Palmer GE, Papassideri I, Parkes M, Perlmutter DH, Perry G, Piacentini M, Pinkas-Kramarski R, Prescott M, Proikas-Cezanne T, Raben N, Rami A, Reggiori F, Rubinsztein DC, Ryan KM, Sadoshima J, Sakagami H, Sakai Y, Sandri M, Sasakawa C, Schneider C, Seglen PO, Seleverstov O, Settleman J, Shacka JJ, Shapiro IM, Sibirny A, Silva-Zacarin EC, Simon HU, Simone C, Simonsen A, Smith MA, Spanel-Borowski K, Srinivas V, Steeves M, Stenmark H, Stromhaug PE, Subauste CS, Sugimoto S, Sulzer D, Suzuki T, Swanson MS, Tabas I, Takeshita F, Talbot NJ, Tanaka K, Tanaka K, Tanida I, Taylor GS, Taylor JP, Terman A, Tettamanti G, Thompson CB, Thumm M, Tolkovsky AM, Tooze SA, Truant R, Tumanovska LV, Uchiyama Y, Ueno T, van der Klei I, Vaquero EC, Vellai T, Vogel MW, Wang HG, Webster P, Wiley JW, Xi Z, Xiao G, Yahalom J, Yang JM, Yap G, Yin XM, Yoshimori T, Yu L, Yue Z, Yuzaki M, Zabirnyk O, Zheng X, Zhu X, Deter RL, Clav? C, Colombo MI, Dr?ge W, F?s?s L, Fuentes JM, Gonz?lez-Est?vez C, H?ussinger D, H?yer-Hansen M, J??ttel? M, Kov?cs AL, L?pez-Ot?n C, Mel?ndez A, M?nz C, N?rnberg B, Rohrer B, Sass M, Tall?czy Z, Uzc?tegui NL. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 2008 Feb; 4(2):151-75. PMID: 18188003; PMCID: PMC2654259.
      Citations: 1171     Fields:    Translation:HumansAnimalsCells
    116. Ozpolat B, Akar U, Mehta K, Lopez-Berestein G. PKC delta and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells. Autophagy. 2007 Sep-Oct; 3(5):480-3. PMID: 17507797.
      Citations: 35     Fields:    Translation:HumansCells
    117. Akar U, Ozpolat B, Mehta K, Fok J, Kondo Y, Lopez-Berestein G. Tissue transglutaminase inhibits autophagy in pancreatic cancer cells. Mol Cancer Res. 2007 Mar; 5(3):241-9. PMID: 17374730.
      Citations: 52     Fields:    Translation:HumansCells
    118. Ozpolat B, Akar U, Steiner M, Zorrilla-Calancha I, Tirado-Gomez M, Colburn N, Danilenko M, Kornblau S, Berestein GL. Programmed cell death-4 tumor suppressor protein contributes to retinoic acid-induced terminal granulocytic differentiation of human myeloid leukemia cells. Mol Cancer Res. 2007 Jan; 5(1):95-108. PMID: 17259349.
      Citations: 34     Fields:    Translation:HumansCells
    119. Ozpolat B, Mehta K, Lopez-Berestein G. Regulation of a highly specific retinoic acid-4-hydroxylase (CYP26A1) enzyme and all-trans-retinoic acid metabolism in human intestinal, liver, endothelial, and acute promyelocytic leukemia cells. Leuk Lymphoma. 2005 Oct; 46(10):1497-506. PMID: 16194896.
      Citations: 16     Fields:    Translation:HumansCells
    120. Harris MN, Ozpolat B, Abdi F, Gu S, Legler A, Mawuenyega KG, Tirado-Gomez M, Lopez-Berestein G, Chen X. Comparative proteomic analysis of all-trans-retinoic acid treatment reveals systematic posttranscriptional control mechanisms in acute promyelocytic leukemia. Blood. 2004 Sep 01; 104(5):1314-23. PMID: 15142884.
      Citations: 28     Fields:    Translation:HumansCells
    121. Ozpolat B, Tari AM, Mehta K, Lopez-Berestein G. Nuclear retinoid receptors are involved in N-(4-hydroxyphenyl) retinamide (Fenretinide)-induced gene expression and growth inhibition in HL-60 acute myeloid leukemia cells. Leuk Lymphoma. 2004 May; 45(5):979-85. PMID: 15291358.
      Citations: 6     Fields:    Translation:HumansCells
    122. Ozpolat B, Lopez-Berestein G, Adamson P, Fu CJ, Williams AH. Pharmacokinetics of intravenously administered liposomal all-trans-retinoic acid (ATRA) and orally administered ATRA in healthy volunteers. J Pharm Pharm Sci. 2003 May-Aug; 6(2):292-301. PMID: 12935441.
      Citations: 33     Fields:    Translation:HumansCTClinical Trials
    123. Lachman LB, Ozpolat B. Liposomal cytokines and liposomes targeted to costimulatory molecules as adjuvants for human immunodeficiency virus subunit vaccines. Methods Enzymol. 2003; 373:92-100. PMID: 14714398.
      Citations: 2     Fields:    Translation:Animals
    124. Mitarnun W, Suwiwat S, Pradutkanchana J, Saechan V, Ishida T, Takao S, Mori A. Epstein-Barr virus-associated peripheral T-cell and NK-cell proliferative disease/lymphoma: clinicopathologic, serologic, and molecular analysis. Am J Hematol. 2002 May; 70(1):31-8. PMID: 11994979.
      Citations: 4     Fields:    Translation:HumansCells
    125. Ozpolat B, Lopez-Berestein G. Liposomal-all-trans-retinoic acid in treatment of acute promyelocytic leukemia. Leuk Lymphoma. 2002 May; 43(5):933-41. PMID: 12148903.
      Citations: 6     Fields:    Translation:Humans
    126. Ozpolat B, Mehta K, Tari AM, Lopez-Berestein G. all-trans-Retinoic acid-induced expression and regulation of retinoic acid 4-hydroxylase (CYP26) in human promyelocytic leukemia. Am J Hematol. 2002 May; 70(1):39-47. PMID: 11994980.
      Citations: 20     Fields:    Translation:HumansCells
    127. Lachman LB, Rao XM, Kremer RH, Ozpolat B, Kiriakova G, Price JE. DNA vaccination against neu reduces breast cancer incidence and metastasis in mice. Cancer Gene Ther. 2001 Apr; 8(4):259-68. PMID: 11393278.
      Citations: 23     Fields:    Translation:AnimalsCellsPHPublic Health
    128. Ozpolat B, Rao XM, Lachman LB, Osato MS, Graham DY. Quantitative and bioluminescent assay to measure efficacy of conventional and DNA vaccinations against Helicobacter pylori. Comb Chem High Throughput Screen. 2000 Aug; 3(4):289-302. PMID: 10974142.
      Citations: 2     Fields:    Translation:AnimalsCells
    129. Ozpolat B, Actor JK, Rao XM, Lee S, Osato M, Graham DY, Lachman LB. Quantitation of Helicobacter pylori in the stomach using quantitative polymerase chain reaction assays. Helicobacter. 2000 Mar; 5(1):13-21. PMID: 10672046.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    130. Ozpolat B, Rao XM, Powell MF, Lachman LB. Immunoliposomes containing antibodies to costimulatory molecules as adjuvants for HIV subunit vaccines. AIDS Res Hum Retroviruses. 1998 Mar 20; 14(5):409-17. PMID: 9546800.
      Citations: 2     Fields:    Translation:HumansAnimals
    131. Lachman LB, Ozpolat B, Rao XM, Graham DY, Osato M. Development of a murine model of Helicobacter pylori infection. Helicobacter. 1997 Jun; 2(2):78-81. PMID: 9432332.
      Citations: 3     Fields:    Translation:AnimalsCells
    132. Acute promyelocytic leukemia and differentiation therapy. Turkish Journal of Hematology. 26:47-61.
    133. Therapeutic silencing of Bcl-2 by systemically administered siRNA nanotherapeutics inhibits tumor growth by autophagy and apoptosis and enhances the efficacy of chemotherapy in orthotopic xenograft models of ER (-) and ER (+) breast cancer. Molecular Therapy - Nucleic Acids. 2.
    134. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 28:610-622.
    135. PKCδ and tissue transglutaminase are novel inhibitors of autophagy in pancreatic cancer cells (Autophagy (2007) 3 (480-483)). Autophagy. 5:283.
    136. Liposomal Cytokines and Liposomes Targeted to Co-Stimulatory Molecules as Adjuvants for HIV Subunit Vaccines. 249-261.
    137. Induction of autophagy by polyphenolic compounds in cancer. 237-261.
    138. A selective serotonin 5-HT1B receptor inhibition suppresses cells proliferation and induces apoptosis in human uterine leiomyoma cells. European Journal of Obstetrics Gynecology and Reproductive Biology. 206:114-119.
    139. Corrigendum to "Purification and characterization of tagless recombinant human elongation factor 2 kinase (eEF-2K) expressed in Escherichia coli" [Protein Expression and Purification 79 (2011) 237-244] (DOI. Protein Expression and Purification.
    140. Growth and differentiation factors as cancer therapeutics. 527-568.
    141. FOXM1 regulates expression of eukaryotic elongation factor 2 kinase and promotes proliferation, invasion and tumorgenesis of human triple negative breast cancer cells. Oncotarget. 7:16619-16635.
    142. Preclinical and clinical development of siRNA-based therapeutics. Advanced Drug Delivery Reviews.
    143. Ubiquitous release of exosomal tumor suppressor miR-6126 from ovarian cancer cells. Cancer Research. 76:7194-7207.
    144. Targeting autophagy in cancer management-strategies and developments. Cancer Management and Research. 7:291-299.
    145. Resistance to differentiation therapy. 233-255.
    146. Proteoimic analysis of all-trans-retinoic acid treated acute promyelocytic leukemia cells using mass spectrometry and amino acid specific stable isotope labeling. 293-294.
    147. Erratum to. Autophagy. 12:443.
    148. Oligonucleotide-based theranostic nanoparticles in cancer therapy. Nanomedicine. 11:1287-1308.
    149. Rac1/Pak1/p38/MMP-2 axis regulates angiogenesis in ovarian cancer. Clinical Cancer Research. 21:2127-2137.
    150. The ZNF304-integrin axis protects against anoikis in cancer. Nature Communications. 6.
    151. Dedifferentiation of patient-derived glioblastoma multiforme cell lines results in a cancer stem cell-like state with mitogen-independent growth. Journal of Cellular and Molecular Medicine. 19:1262-1272.
    152. Recombinant proteins and genomics in cancer therapy. 53-83.
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