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UMA RAJU

TitleAssistant Professor
InstitutionMD Anderson
DepartmentRadiation Oncology
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Hao C, Shao R, Raju U, Fang B, Swisher SG, Pataer A. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 2016 Jun 21; 7(25):38235-38242. PMID: 27203671.
      View in: PubMed
    2. Deorukhkar A, Ahuja N, Mercado AL, Diagaradjane P, Raju U, Patel N, Mohindra P, Diep N, Guha S, Krishnan S. Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. Cancer Med. 2015 Feb; 4(2):278-92. PMID: 25450478.
      View in: PubMed
    3. Wang ZQ, Johnson CL, Kumar A, Molkentine DP, Molkentine JM, Rabin T, Mason KA, Milas L, Raju U. Inhibition of P-TEFb by DRB suppresses SIRT1/CK2a pathway and enhances radiosensitivity of human cancer cells. Anticancer Res. 2014 Dec; 34(12):6981-9. PMID: 25503124.
      View in: PubMed
    4. Raju U, Molkentine DP, Valdecanas DR, Deorukhkar A, Mason KA, Buchholz TA, Meyn RE, Ang KK, Skinner H. Inhibition of EGFR or IGF-1R signaling enhances radiation response in head and neck cancer models but concurrent inhibition has no added benefit. Cancer Med. 2015 Jan; 4(1):65-74. PMID: 25355701.
      View in: PubMed
    5. Mason KA, Raju U, Buchholz TA, Wang L, Milas ZL, Milas L. Poly (ADP-ribose) polymerase inhibitors in cancer treatment. Am J Clin Oncol. 2014 Feb; 37(1):90-100. PMID: 22495455.
      View in: PubMed
    6. Raju U, Riesterer O, Wang ZQ, Molkentine DP, Molkentine JM, Johnson FM, Glisson B, Milas L, Ang KK. Dasatinib, a multi-kinase inhibitor increased radiation sensitivity by interfering with nuclear localization of epidermal growth factor receptor and by blocking DNA repair pathways. Radiother Oncol. 2012 Nov; 105(2):241-9. PMID: 23010482.
      View in: PubMed
    7. Bhardwaj V, Zhan Y, Cortez MA, Ang KK, Molkentine D, Munshi A, Raju U, Komaki R, Heymach JV, Welsh J. C-Met inhibitor MK-8003 radiosensitizes c-Met-expressing non-small-cell lung cancer cells with radiation-induced c-Met-expression. J Thorac Oncol. 2012 Aug; 7(8):1211-7. PMID: 22617250.
      View in: PubMed
    8. Matsumoto F, Valdecanas DN, Mason KA, Milas L, Ang KK, Raju U. The impact of timing of EGFR and IGF-1R inhibition for sensitizing head and neck cancer to radiation. Anticancer Res. 2012 Aug; 32(8):3029-35. PMID: 22843870.
      View in: PubMed
    9. Wang L, Raju U, Milas L, Molkentine D, Zhang Z, Yang P, Cohen L, Meng Z, Liao Z. Huachansu, containing cardiac glycosides, enhances radiosensitivity of human lung cancer cells. Anticancer Res. 2011 Jun; 31(6):2141-8. PMID: 21737634.
      View in: PubMed
    10. Moeller BJ, Yordy JS, Williams MD, Giri U, Raju U, Molkentine DP, Byers LA, Heymach JV, Story MD, Lee JJ, Sturgis EM, Weber RS, Garden AS, Ang KK, Schwartz DL. DNA repair biomarker profiling of head and neck cancer: Ku80 expression predicts locoregional failure and death following radiotherapy. Clin Cancer Res. 2011 Apr 01; 17(7):2035-43. PMID: 21349997.
      View in: PubMed
    11. Koto M, Cho H, Riesterer O, Giri U, Story MD, Ha CS, Raju U. Human lymphoma cells develop resistance to radiation in the presence of astrocytes in vitro. Anticancer Res. 2011 Jan; 31(1):33-8. PMID: 21273577.
      View in: PubMed
    12. Riesterer O, Yang Q, Raju U, Torres M, Molkentine D, Patel N, Valdecanas D, Milas L, Ang KK. Combination of anti-IGF-1R antibody A12 and ionizing radiation in upper respiratory tract cancers. Int J Radiat Oncol Biol Phys. 2011 Mar 15; 79(4):1179-87. PMID: 21129859.
      View in: PubMed
    13. Skvortsova I, Skvortsov S, Raju U, Stasyk T, Riesterer O, Schottdorf EM, Popper BA, Schiestl B, Eichberger P, Debbage P, Neher A, Bonn GK, Huber LA, Milas L, Lukas P. Epithelial-to-mesenchymal transition and c-myc expression are the determinants of cetuximab-induced enhancement of squamous cell carcinoma radioresponse. Radiother Oncol. 2010 Jul; 96(1):108-15. PMID: 20451273.
      View in: PubMed
    14. Torres MA, Raju U, Molkentine D, Riesterer O, Milas L, Ang KK. AC480, formerly BMS-599626, a pan Her inhibitor, enhances radiosensitivity and radioresponse of head and neck squamous cell carcinoma cells in vitro and in vivo. Invest New Drugs. 2011 Aug; 29(4):554-61. PMID: 20119866.
      View in: PubMed
    15. Riesterer O, Matsumoto F, Wang L, Pickett J, Molkentine D, Giri U, Milas L, Raju U. A novel Chk inhibitor, XL-844, increases human cancer cell radiosensitivity through promotion of mitotic catastrophe. Invest New Drugs. 2011 Jun; 29(3):514-22. PMID: 20024691.
      View in: PubMed
    16. Cho H, Koto M, Riesterer O, Molkentine DP, Giri U, Milas L, Story MD, Ha CS, Raju U. Imexon augments sensitivity of human lymphoma cells to ionizing radiation: in vitro experimental study. Anticancer Res. 2009 Nov; 29(11):4409-15. PMID: 20032386.
      View in: PubMed
    17. Riesterer O, Mason KA, Raju U, Yang Q, Wang L, Hittelman WN, Ang KK, Milas L. Enhanced response to C225 of A431 tumor xenografts growing in irradiated tumor bed. Radiother Oncol. 2009 Sep; 92(3):383-7. PMID: 19695723.
      View in: PubMed
    18. Skvortsova I, Skvortsov S, Stasyk T, Raju U, Popper BA, Schiestl B, von Guggenberg E, Neher A, Bonn GK, Huber LA, Lukas P. Intracellular signaling pathways regulating radioresistance of human prostate carcinoma cells. Proteomics. 2008 Nov; 8(21):4521-33. PMID: 18821526.
      View in: PubMed
    19. Dittmann KH, Mayer C, Ohneseit PA, Raju U, Andratschke NH, Milas L, Rodemann HP. Celecoxib induced tumor cell radiosensitization by inhibiting radiation induced nuclear EGFR transport and DNA-repair: a COX-2 independent mechanism. Int J Radiat Oncol Biol Phys. 2008 Jan 01; 70(1):203-12. PMID: 17996386.
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    20. von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res. 2007 Oct 15; 13(20):6032-9. PMID: 17947465.
      View in: PubMed
    21. Wiedenmann N, Koto M, Raju U, Milas L, Mason KA. Modulation of tumor radiation response with G3139, a bcl-2 antisense oligonucleotide. Invest New Drugs. 2007 Oct; 25(5):411-6. PMID: 17492397.
      View in: PubMed
    22. Raju U, Ariga H, Koto M, Lu X, Pickett J, Valdecanas D, Mason KA, Milas L. Improvement of esophageal adenocarcinoma cell and xenograft responses to radiation by targeting cyclin-dependent kinases. Radiother Oncol. 2006 Aug; 80(2):185-91. PMID: 16905211.
      View in: PubMed
    23. Apisarnthanarax S, Alauddin MM, Mourtada F, Ariga H, Raju U, Mawlawi O, Han D, Bornmann WG, Ajani JA, Milas L, Gelovani JG, Chao KS. Early detection of chemoradioresponse in esophageal carcinoma by 3'-deoxy-3'-3H-fluorothymidine using preclinical tumor models. Clin Cancer Res. 2006 Aug 01; 12(15):4590-7. PMID: 16899606.
      View in: PubMed
    24. Milas L, Raju U, Liao Z, Ajani J. Targeting molecular determinants of tumor chemo-radioresistance. Semin Oncol. 2005 Dec; 32(6 Suppl 9):S78-81. PMID: 16399438.
      View in: PubMed
    25. Raju U, Ariga H, Dittmann K, Nakata E, Ang KK, Milas L. Inhibition of DNA repair as a mechanism of enhanced radioresponse of head and neck carcinoma cells by a selective cyclooxygenase-2 inhibitor, celecoxib. Int J Radiat Oncol Biol Phys. 2005 Oct 01; 63(2):520-8. PMID: 16168844.
      View in: PubMed
    26. Dittmann K, Mayer C, Fehrenbacher B, Schaller M, Raju U, Milas L, Chen DJ, Kehlbach R, Rodemann HP. Radiation-induced epidermal growth factor receptor nuclear import is linked to activation of DNA-dependent protein kinase. J Biol Chem. 2005 Sep 02; 280(35):31182-9. PMID: 16000298.
      View in: PubMed
    27. Mason KA, Hunter NR, Raju U, Ariga H, Husain A, Valdecanas D, Neal R, Ang KK, Milas L. Flavopiridol increases therapeutic ratio of radiotherapy by preferentially enhancing tumor radioresponse. Int J Radiat Oncol Biol Phys. 2004 Jul 15; 59(4):1181-9. PMID: 15234054.
      View in: PubMed
    28. Ismail SM, Puppi M, Prithivirajsingh S, Munshi A, Raju U, Meyn RE, Buchholz TA, Story MD, Brock WA, Milas L, Thames HD, Stevens CW. Predicting radiosensitivity using DNA end-binding complex analysis. Clin Cancer Res. 2004 Feb 15; 10(4):1226-34. PMID: 14977819.
      View in: PubMed
    29. Nakata E, Mason KA, Hunter N, Husain A, Raju U, Liao Z, Ang KK, Milas L. Potentiation of tumor response to radiation or chemoradiation by selective cyclooxygenase-2 enzyme inhibitors. Int J Radiat Oncol Biol Phys. 2004 Feb 01; 58(2):369-75. PMID: 14751505.
      View in: PubMed
    30. Raju U, Nakata E, Mason KA, Ang KK, Milas L. Flavopiridol, a cyclin-dependent kinase inhibitor, enhances radiosensitivity of ovarian carcinoma cells. Cancer Res. 2003 Jun 15; 63(12):3263-7. PMID: 12810657.
      View in: PubMed
    31. Nasu S, Milas L, Kawabe S, Raju U, Newman R. Enhancement of radiotherapy by oleandrin is a caspase-3 dependent process. Cancer Lett. 2002 Nov 28; 185(2):145-51. PMID: 12169388.
      View in: PubMed
    32. Raju U, Nakata E, Yang P, Newman RA, Ang KK, Milas L. In vitro enhancement of tumor cell radiosensitivity by a selective inhibitor of cyclooxygenase-2 enzyme: mechanistic considerations. Int J Radiat Oncol Biol Phys. 2002 Nov 01; 54(3):886-94. PMID: 12377342.
      View in: PubMed
    33. Russell JS, Raju U, Gumin GJ, Lang FF, Wilson DR, Huet T, Tofilon PJ. Inhibition of radiation-induced nuclear factor-kappaB activation by an anti-Ras single-chain antibody fragment: lack of involvement in radiosensitization. Cancer Res. 2002 Apr 15; 62(8):2318-26. PMID: 11956090.
      View in: PubMed
    34. Raju U, Gumin GJ, Tofilon PJ. Radiation-induced transcription factor activation in the rat cerebral cortex. Int J Radiat Biol. 2000 Aug; 76(8):1045-53. PMID: 10947117.
      View in: PubMed
    35. Noel F, Raju U, Happel E, Marchionni MA, Tofilon PJ. X-irradiation-induced loss of O-2A progenitor cells in rat spinal cord is inhibited by implants of cells engineered to secrete glial growth factor 2. Neuroreport. 1999 Feb 25; 10(3):535-40. PMID: 10208585.
      View in: PubMed
    36. Raju U, Gumin GJ, Tofilon PJ. NF kappa B activity and target gene expression in the rat brain after one and two exposures to ionizing radiation. Radiat Oncol Investig. 1999; 7(3):145-52. PMID: 10406055.
      View in: PubMed
    37. Noel F, Gumin GJ, Raju U, Tofilon PJ. Increased expression of prohormone convertase-2 in the irradiated rat brain. FASEB J. 1998 Dec; 12(15):1725-30. PMID: 9837862.
      View in: PubMed
    38. Raju U, Gumin GJ, Noel F, Tofilon PJ. IkappaBalpha degradation is not a requirement for the X-ray-induced activation of nuclear factor kappaB in normal rat astrocytes and human brain tumour cells. Int J Radiat Biol. 1998 Nov; 74(5):617-24. PMID: 9848280.
      View in: PubMed
    39. Singh S, Raju U, Mendoza J, Pantazis P, Aggarwal BB. Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells. Anticancer Drugs. 1998 Sep; 9(8):703-14. PMID: 9823429.
      View in: PubMed
    40. Lang FF, Yung WK, Raju U, Libunao F, Terry NH, Tofilon PJ. Enhancement of radiosensitivity of wild-type p53 human glioma cells by adenovirus-mediated delivery of the p53 gene. J Neurosurg. 1998 Jul; 89(1):125-32. PMID: 9647183.
      View in: PubMed
    41. Raju U, Lu R, Noel F, Gumin GJ, Tofilon PJ. Failure of a second X-ray dose to activate nuclear factor kappaB in normal rat astrocytes. J Biol Chem. 1997 Sep 26; 272(39):24624-30. PMID: 9305931.
      View in: PubMed
    42. McClain K, Estrov Z, Raju U, Kelley PK, Aggarwal BB. Epstein-Barr Virus EBNA-2 gene expression enhances lymphotoxin production by B lymphocytes. Methods. 1997 Jan; 11(1):83-7. PMID: 8990093.
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    43. Chainy GB, Singh S, Raju U, Aggarwal BB. Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors. J Immunol. 1996 Sep 15; 157(6):2410-7. PMID: 8805640.
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    44. Koumenis C, Nunez-Regueiro M, Raju U, Cook R, Eskin A. Identification of three proteins in the eye of Aplysia, whose synthesis is altered by serotonin (5-HT). Possible involvement of these proteins in the ocular circadian system. J Biol Chem. 1995 Jun 16; 270(24):14619-27. PMID: 7782325.
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    45. Noel F, Koumenis C, Nunez-Regueiro M, Raju U, Byrne JH, Eskin A. Effects on protein synthesis produced by pairing depolarization with serotonin, an analogue of associative learning in Aplysia. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4150-4. PMID: 8183885.
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    46. Raju U, Nunez-Regueiro M, Cook R, Kaetzel MA, Yeung SC, Eskin A. Identification of an annexin-like protein and its possible role in the Aplysia eye circadian system. J Neurochem. 1993 Oct; 61(4):1236-45. PMID: 8376982.
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    47. Raju U, Koumenis C, Nunez-Regueiro M, Eskin A. Alteration of the phase and period of a circadian oscillator by a reversible transcription inhibitor. Science. 1991 Aug 09; 253(5020):673-5. PMID: 1871602.
      View in: PubMed
    48. Raju U, Yeung SJ, Eskin A. Involvement of proteins in light resetting ocular circadian oscillators of Aplysia. Am J Physiol. 1990 Jan; 258(1 Pt 2):R256-62. PMID: 2154135.
      View in: PubMed
    49. TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene.
    50. E16 - Integration of molecular targeting with radiotherapy. Strahlentherapie und Onkologie. 183:70-72.
    51. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 7:38235-38242.
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