CLAUDIO M ALDAZ

TitleProfessor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPO Box 389
Smithville TX 78957-0389
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ferretti VA, Canzoneri R, Palma S, Lacunza E, Aldaz CM, Abba MC. RHBDD2-WWOX protein interaction during proliferative and differentiated stages in normal and breast cancer cells. Oncol Rep. 2021 Aug; 46(2). PMID: 34109992.
      Citations:    Fields:    
    2. Zeng Z, Chen W, Moshensky A, Shakir Z, Khan R, Crotty Alexander LE, Ware LB, Aldaz CM, Jacobson JR, Dudek SM, Natarajan V, Machado RF, Singla S. Cigarette Smoke and Nicotine-Containing Electronic-Cigarette Vapor Downregulate Lung WWOX Expression, Which Is Associated with Increased Severity of Murine Acute Respiratory Distress Syndrome. Am J Respir Cell Mol Biol. 2021 01; 64(1):89-99. PMID: 33058734.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Trinh A, Gil Del Alcazar CR, Shukla SA, Chin K, Chang YH, Thibault G, Eng J, Jovanovic B, Aldaz CM, Park SY, Jeong J, Wu C, Gray J, Polyak K. Genomic Alterations during the In Situ to Invasive Ductal Breast Carcinoma Transition Shaped by the Immune System. Mol Cancer Res. 2021 04; 19(4):623-635. PMID: 33443130.
      Citations: 1     Fields:    
    4. Aldaz CM, Hussain T. WWOX Loss of Function in Neurodevelopmental and Neurodegenerative Disorders. Int J Mol Sci. 2020 Nov 24; 21(23). PMID: 33255508.
      Citations: 3     Fields:    Translation:HumansAnimals
    5. Abba MC, Canzoneri R, Gurruchaga A, Lee J, Tatineni P, Kil H, Lacunza E, Aldaz CM. LINC00885 a Novel Oncogenic Long Non-Coding RNA Associated with Early Stage Breast Cancer Progression. Int J Mol Sci. 2020 Oct 08; 21(19). PMID: 33049922.
      Citations: 1     Fields:    Translation:HumansCells
    6. McBride KM, Kil H, Mu Y, Plummer JB, Lee J, Zelazowski MJ, Sebastian M, Abba MC, Aldaz CM. Wwox Deletion in Mouse B Cells Leads to Genomic Instability, Neoplastic Transformation, and Monoclonal Gammopathies. Front Oncol. 2019; 9:517. PMID: 31275852.
      Citations: 2     
    7. Hussain T, Liu B, Shrock MS, Williams T, Aldaz CM. WWOX, the FRA16D gene: A target of and a contributor to genomic instability. Genes Chromosomes Cancer. 2019 05; 58(5):324-338. PMID: 30350478.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    8. Hussain T, Lee J, Abba MC, Chen J, Aldaz CM. Delineating WWOX Protein Interactome by Tandem Affinity Purification-Mass Spectrometry: Identification of Top Interactors and Key Metabolic Pathways Involved. Front Oncol. 2018; 8:591. PMID: 30619736.
      Citations: 10     
    9. Hussain T, Kil H, Hattiangady B, Lee J, Kodali M, Shuai B, Attaluri S, Takata Y, Shen J, Abba MC, Shetty AK, Aldaz CM. Wwox deletion leads to reduced GABA-ergic inhibitory interneuron numbers and activation of microglia and astrocytes in mouse hippocampus. Neurobiol Dis. 2019 01; 121:163-176. PMID: 30290271.
      Citations: 9     Fields:    Translation:AnimalsCells
    10. Visschedijk MC, Spekhorst LM, Cheng SC, van Loo ES, Jansen BHD, Blokzijl T, Kil H, de Jong DJ, Pierik M, Maljaars JPWJ, van der Woude CJ, van Bodegraven AA, Oldenburg B, Löwenberg M, Nieuwenhuijs VB, Imhann F, van Sommeren S, Alberts R, Xavier RJ, Dijkstra G, Nico Faber K, Aldaz CM, Weersma RK, Festen EAM. Genomic and Expression Analyses Identify a Disease-Modifying Variant for Fibrostenotic Crohn's Disease. J Crohns Colitis. 2018 04 27; 12(5):582-588. PMID: 29361163.
      Citations: 4     Fields:    Translation:Humans
    11. Schrock MS, Batar B, Lee J, Druck T, Ferguson B, Cho JH, Akakpo K, Hagrass H, Heerema NA, Xia F, Parvin JD, Aldaz CM, Huebner K. Wwox-Brca1 interaction: role in DNA repair pathway choice. Oncogene. 2017 04 20; 36(16):2215-2227. PMID: 27869163.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    12. Abba MC, Zhong Y, Lee J, Kil H, Lu Y, Takata Y, Simper MS, Gaddis S, Shen J, Aldaz CM. DMBA induced mouse mammary tumors display high incidence of activating Pik3caH1047 and loss of function Pten mutations. Oncotarget. 2016 Sep 27; 7(39):64289-64299. PMID: 27588403.
      Citations: 17     Fields:    Translation:AnimalsCells
    13. Abba MC, Gong T, Lu Y, Lee J, Zhong Y, Lacunza E, Butti M, Takata Y, Gaddis S, Shen J, Estecio MR, Sahin AA, Aldaz CM. A Molecular Portrait of High-Grade Ductal Carcinoma In Situ. Cancer Res. 2015 Sep 15; 75(18):3980-90. PMID: 26249178.
      Citations: 48     Fields:    Translation:HumansCells
    14. Aldaz CM, Ferguson BW, Abba MC. WWOX at the crossroads of cancer, metabolic syndrome related traits and CNS pathologies. Biochim Biophys Acta. 2014 Aug; 1846(1):188-200. PMID: 24932569.
      Citations: 49     Fields:    Translation:HumansAnimals
    15. Iatan I, Choi HY, Ruel I, Reddy MV, Kil H, Lee J, Odeh MA, Salah Z, Abu-Remaileh M, Weissglas-Volkov D, Nikkola E, Civelek M, Awan Z, Croce CM, Aqeilan RI, Pajukanta P, Aldaz CM, Genest J. The WWOX gene modulates high-density lipoprotein and lipid metabolism. Circ Cardiovasc Genet. 2014 Aug; 7(4):491-504. PMID: 24871327.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    16. Lacunza E, Rabassa ME, Canzoneri R, Pellon-Maison M, Croce MV, Aldaz CM, Abba MC. Identification of signaling pathways modulated by RHBDD2 in breast cancer cells: a link to the unfolded protein response. Cell Stress Chaperones. 2014 May; 19(3):379-88. PMID: 24078384.
      Citations: 3     Fields:    Translation:HumansCells
    17. Mallaret M, Synofzik M, Lee J, Sagum CA, Mahajnah M, Sharkia R, Drouot N, Renaud M, Klein FA, Anheim M, Tranchant C, Mignot C, Mandel JL, Bedford M, Bauer P, Salih MA, Schüle R, Schöls L, Aldaz CM, Koenig M. The tumour suppressor gene WWOX is mutated in autosomal recessive cerebellar ataxia with epilepsy and mental retardation. Brain. 2014 Feb; 137(Pt 2):411-9. PMID: 24369382.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    18. Ferguson BW, Gao X, Zelazowski MJ, Lee J, Jeter CR, Abba MC, Aldaz CM. The cancer gene WWOX behaves as an inhibitor of SMAD3 transcriptional activity via direct binding. BMC Cancer. 2013 Dec 11; 13:593. PMID: 24330518.
      Citations: 24     Fields:    Translation:HumansCells
    19. Gogada R, Yadav N, Liu J, Tang S, Zhang D, Schneider A, Seshadri A, Sun L, Aldaz CM, Tang DG, Chandra D. Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer. J Biol Chem. 2013 Jan 04; 288(1):368-81. PMID: 23152504.
      Citations: 34     Fields:    Translation:HumansCells
    20. Ferguson BW, Gao X, Kil H, Lee J, Benavides F, Abba MC, Aldaz CM. Conditional Wwox deletion in mouse mammary gland by means of two Cre recombinase approaches. PLoS One. 2012; 7(5):e36618. PMID: 22574198.
      Citations: 20     Fields:    Translation:AnimalsCells
    21. Thangavel C, Dean JL, Ertel A, Knudsen KE, Aldaz CM, Witkiewicz AK, Clarke R, Knudsen ES. Therapeutically activating RB: reestablishing cell cycle control in endocrine therapy-resistant breast cancer. Endocr Relat Cancer. 2011 Jun; 18(3):333-45. PMID: 21367843.
      Citations: 99     Fields:    Translation:HumansCells
    22. Yan L, Della Coletta L, Powell KL, Shen J, Thames H, Aldaz CM, MacLeod MC. Activation of the canonical Wnt/ß-catenin pathway in ATF3-induced mammary tumors. PLoS One. 2011 Jan 31; 6(1):e16515. PMID: 21304988.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    23. Abba MC, Lacunza E, Butti M, Aldaz CM. Breast cancer biomarker discovery in the functional genomic age: a systematic review of 42 gene expression signatures. Biomark Insights. 2010 Oct 27; 5:103-18. PMID: 21082037.
      Citations: 22     
    24. Ludes-Meyers JH, Kil H, Parker-Thornburg J, Kusewitt DF, Bedford MT, Aldaz CM. Generation and characterization of mice carrying a conditional allele of the Wwox tumor suppressor gene. PLoS One. 2009 Nov 10; 4(11):e7775. PMID: 19936220.
      Citations: 41     Fields:    Translation:HumansAnimals
    25. Krishnan P, Yan KJ, Windler D, Tubbs J, Grand R, Li BD, Aldaz CM, McLarty J, Kleiner-Hancock HE. Citrus auraptene suppresses cyclin D1 and significantly delays N-methyl nitrosourea induced mammary carcinogenesis in female Sprague-Dawley rats. BMC Cancer. 2009 Jul 29; 9:259. PMID: 19640308.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    26. Abba MC, Lacunza E, Nunez MI, Colussi A, Isla-Larrain M, Segal-Eiras A, Croce MV, Aldaz CM. Rhomboid domain containing 2 (RHBDD2): a novel cancer-related gene over-expressed in breast cancer. Biochim Biophys Acta. 2009 Oct; 1792(10):988-97. PMID: 19616622.
      Citations: 17     Fields:    Translation:HumansCells
    27. Abba MC, Hu Y, Levy CC, Gaddis S, Kittrell FS, Hill J, Bissonnette RP, Brown PH, Medina D, Aldaz CM. Identification of modulated genes by three classes of chemopreventive agents at preneoplastic stages in a p53-null mouse mammary tumor model. Cancer Prev Res (Phila). 2009 Feb; 2(2):175-84. PMID: 19174580.
      Citations: 6     Fields:    Translation:Animals
    28. Wang A, Arantes S, Yan L, Kiguchi K, McArthur MJ, Sahin A, Thames HD, Aldaz CM, Macleod MC. The transcription factor ATF3 acts as an oncogene in mouse mammary tumorigenesis. BMC Cancer. 2008 Sep 22; 8:268. PMID: 18808719.
      Citations: 26     Fields:    Translation:Animals
    29. Abba MC, Hu Y, Levy CC, Gaddis S, Kittrell FS, Zhang Y, Hill J, Bissonnette RP, Medina D, Brown PH, Aldaz CM. Transcriptomic signature of bexarotene (rexinoid LGD1069) on mammary gland from three transgenic mouse mammary cancer models. BMC Med Genomics. 2008 Sep 11; 1:40. PMID: 18786257.
      Citations: 6     Fields:    
    30. Ramos D, Abba M, López-Guerrero JA, Rubio J, Solsona E, Almenar S, Llombart-Bosch A, Aldaz CM. Low levels of WWOX protein immunoexpression correlate with tumour grade and a less favourable outcome in patients with urinary bladder tumours. Histopathology. 2008 Jun; 52(7):831-9. PMID: 18452537.
      Citations: 13     Fields:    Translation:Humans
    31. Yadav N, Cheng D, Richard S, Morel M, Iyer VR, Aldaz CM, Bedford MT. CARM1 promotes adipocyte differentiation by coactivating PPARgamma. EMBO Rep. 2008 Feb; 9(2):193-8. PMID: 18188184.
      Citations: 52     Translation:AnimalsCells
    32. Pimenta FJ, Cordeiro GT, Pimenta LG, Viana MB, Lopes J, Gomez MV, Aldaz CM, De Marco L, Gomez RS. Molecular alterations in the tumor suppressor gene WWOX in oral leukoplakias. Oral Oncol. 2008 Aug; 44(8):753-8. PMID: 18061530.
      Citations: 8     Fields:    Translation:Humans
    33. Wu M, Soler DR, Abba MC, Nunez MI, Baer R, Hatzis C, Llombart-Cussac A, Llombart-Bosch A, Aldaz CM. CtIP silencing as a novel mechanism of tamoxifen resistance in breast cancer. Mol Cancer Res. 2007 Dec; 5(12):1285-95. PMID: 18171986.
      Citations: 10     Fields:    Translation:HumansCells
    34. Ludes-Meyers JH, Kil H, Nuñez MI, Conti CJ, Parker-Thornburg J, Bedford MT, Aldaz CM. WWOX hypomorphic mice display a higher incidence of B-cell lymphomas and develop testicular atrophy. Genes Chromosomes Cancer. 2007 Dec; 46(12):1129-36. PMID: 17823927.
      Citations: 38     Fields:    Translation:AnimalsCells
    35. Dias EP, Pimenta FJ, Sarquis MS, Dias Filho MA, Aldaz CM, Fujii JB, Gomez RS, De Marco L. Association between decreased WWOX protein expression and thyroid cancer development. Thyroid. 2007 Nov; 17(11):1055-9. PMID: 18047428.
      Citations: 8     Fields:    Translation:Humans
    36. Abba MC, Sun H, Hawkins KA, Drake JA, Hu Y, Nunez MI, Gaddis S, Shi T, Horvath S, Sahin A, Aldaz CM. Breast cancer molecular signatures as determined by SAGE: correlation with lymph node status. Mol Cancer Res. 2007 Sep; 5(9):881-90. PMID: 17855657.
      Citations: 52     Fields:    Translation:HumansCells
    37. Wang A, Arantes S, Conti C, McArthur M, Aldaz CM, MacLeod MC. Epidermal hyperplasia and oral carcinoma in mice overexpressing the transcription factor ATF3 in basal epithelial cells. Mol Carcinog. 2007 Jun; 46(6):476-87. PMID: 17295236.
      Citations: 16     Fields:    Translation:HumansAnimals
    38. Abba MC, Fabris VT, Hu Y, Kittrell FS, Cai WW, Donehower LA, Sahin A, Medina D, Aldaz CM. Identification of novel amplification gene targets in mouse and human breast cancer at a syntenic cluster mapping to mouse ch8A1 and human ch13q34. Cancer Res. 2007 May 01; 67(9):4104-12. PMID: 17483321.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    39. Nunez MI, Ludes-Meyers J, Aldaz CM. WWOX protein expression in normal human tissues. J Mol Histol. 2006 May; 37(3-4):115-25. PMID: 16941225.
      Citations: 38     Fields:    Translation:Humans
    40. Pimenta FJ, Gomes DA, Perdigão PF, Barbosa AA, Romano-Silva MA, Gomez MV, Aldaz CM, De Marco L, Gomez RS. Characterization of the tumor suppressor gene WWOX in primary human oral squamous cell carcinomas. Int J Cancer. 2006 Mar 01; 118(5):1154-8. PMID: 16152610.
      Citations: 18     Fields:    Translation:HumansCells
    41. Rayala SK, Talukder AH, Balasenthil S, Tharakan R, Barnes CJ, Wang RA, Aldaz CM, Khan S, Kumar R. P21-activated kinase 1 regulation of estrogen receptor-alpha activation involves serine 305 activation linked with serine 118 phosphorylation. Cancer Res. 2006 Feb 01; 66(3):1694-701. PMID: 16452229.
      Citations: 59     Fields:    Translation:HumansCells
    42. Ramos D, Aldaz CM. WWOX, a chromosomal fragile site gene and its role in cancer. Adv Exp Med Biol. 2006; 587:149-59. PMID: 17163164.
      Citations: 10     Fields:    Translation:HumansCells
    43. Abba MC, Nunez MI, Colussi AG, Croce MV, Segal-Eiras A, Aldaz CM. GATA3 protein as a MUC1 transcriptional regulator in breast cancer cells. Breast Cancer Res. 2006; 8(6):R64. PMID: 17078870.
      Citations: 13     Fields:    Translation:HumansCells
    44. Thavathiru E, Ludes-Meyers JH, MacLeod MC, Aldaz CM. Expression of common chromosomal fragile site genes, WWOX/FRA16D and FHIT/FRA3B is downregulated by exposure to environmental carcinogens, UV, and BPDE but not by IR. Mol Carcinog. 2005 Nov; 44(3):174-82. PMID: 16187332.
      Citations: 18     Fields:    Translation:HumansCells
    45. Spyres L, Gaddis S, Bedford E, Arantes S, Liburd N, Powell KL, Thames H, Mitchell D, Walborg E, Rouabhia M, Aldaz CM, MacLeod MC. Quantitative high-throughput measurement of gene expression with sub-zeptomole sensitivity by capillary electrophoresis. Anal Biochem. 2005 Oct 15; 345(2):284-95. PMID: 16125665.
      Citations:    Fields:    Translation:HumansCells
    46. Nunez MI, Rosen DG, Ludes-Meyers JH, Abba MC, Kil H, Page R, Klein-Szanto AJ, Godwin AK, Liu J, Mills GB, Aldaz CM. WWOX protein expression varies among ovarian carcinoma histotypes and correlates with less favorable outcome. BMC Cancer. 2005 Jun 27; 5:64. PMID: 15982416.
      Citations: 37     Fields:    Translation:Humans
    47. Gourley C, Paige AJW, Taylor KJ, Scott D, Francis NJ, Rush R, Aldaz CM, Smyth JF, Gabra H. WWOX mRNA expression profile in epithelial ovarian cancer supports the role of WWOX variant 1 as a tumour suppressor, although the role of variant 4 remains unclear. Int J Oncol. 2005 Jun; 26(6):1681-1689. PMID: 15870886.
      Citations: 20     Fields:    Translation:Humans
    48. Abba MC, Hu Y, Sun H, Drake JA, Gaddis S, Baggerly K, Sahin A, Aldaz CM. Gene expression signature of estrogen receptor alpha status in breast cancer. BMC Genomics. 2005 Mar 11; 6:37. PMID: 15762987.
      Citations: 63     Fields:    Translation:HumansCells
    49. Nunez MI, Ludes-Meyers J, Abba MC, Kil H, Abbey NW, Page RE, Sahin A, Klein-Szanto AJ, Aldaz CM. Frequent loss of WWOX expression in breast cancer: correlation with estrogen receptor status. Breast Cancer Res Treat. 2005 Jan; 89(2):99-105. PMID: 15692750.
      Citations: 46     Fields:    Translation:Humans
    50. Rundhaug JE, Hawkins KA, Pavone A, Gaddis S, Kil H, Klein RD, Berton TR, McCauley E, Johnson DG, Lubet RA, Fischer SM, Aldaz CM. SAGE profiling of UV-induced mouse skin squamous cell carcinomas, comparison with acute UV irradiation effects. Mol Carcinog. 2005 Jan; 42(1):40-52. PMID: 15547921.
      Citations: 14     Fields:    Translation:Animals
    51. Hu Y, Sun H, Drake J, Kittrell F, Abba MC, Deng L, Gaddis S, Sahin A, Baggerly K, Medina D, Aldaz CM. From mice to humans: identification of commonly deregulated genes in mammary cancer via comparative SAGE studies. Cancer Res. 2004 Nov 01; 64(21):7748-55. PMID: 15520179.
      Citations: 26     Fields:    Translation:HumansAnimals
    52. Baggerly KA, Deng L, Morris JS, Aldaz CM. Overdispersed logistic regression for SAGE: modelling multiple groups and covariates. BMC Bioinformatics. 2004 Oct 06; 5:144. PMID: 15469612.
      Citations: 24     Fields:    Translation:HumansCells
    53. Wang B, Rouzier R, Albarracin CT, Sahin A, Wagner P, Yang Y, Smith TL, Meric-Bernstam F, Marcelo Aldaz C, Marcelo AC, Hortobagyi GN, Pusztai L. Expression of sigma 1 receptor in human breast cancer. Breast Cancer Res Treat. 2004 Oct; 87(3):205-14. PMID: 15528963.
      Citations: 22     Fields:    Translation:HumansCells
    54. Park SW, Ludes-Meyers J, Zimonjic DB, Durkin ME, Popescu NC, Aldaz CM. Frequent downregulation and loss of WWOX gene expression in human hepatocellular carcinoma. Br J Cancer. 2004 Aug 16; 91(4):753-9. PMID: 15266310.
      Citations: 36     Fields:    Translation:HumansCells
    55. Abba MC, Drake JA, Hawkins KA, Hu Y, Sun H, Notcovich C, Gaddis S, Sahin A, Baggerly K, Aldaz CM. Transcriptomic changes in human breast cancer progression as determined by serial analysis of gene expression. Breast Cancer Res. 2004; 6(5):R499-513. PMID: 15318932.
      Citations: 52     Fields:    Translation:HumansCells
    56. Ludes-Meyers JH, Kil H, Bednarek AK, Drake J, Bedford MT, Aldaz CM. WWOX binds the specific proline-rich ligand PPXY: identification of candidate interacting proteins. Oncogene. 2004 Jun 24; 23(29):5049-55. PMID: 15064722.
      Citations: 55     Fields:    Translation:HumansCells
    57. Baggerly KA, Deng L, Morris JS, Aldaz CM. Differential expression in SAGE: accounting for normal between-library variation. Bioinformatics. 2003 Aug 12; 19(12):1477-83. PMID: 12912827.
      Citations: 145     Fields:    
    58. Yadav N, Lee J, Kim J, Shen J, Hu MC, Aldaz CM, Bedford MT. Specific protein methylation defects and gene expression perturbations in coactivator-associated arginine methyltransferase 1-deficient mice. Proc Natl Acad Sci U S A. 2003 May 27; 100(11):6464-8. PMID: 12756295.
      Citations: 115     Fields:    Translation:AnimalsCells
    59. Fischer SM, Conti CJ, Viner J, Aldaz CM, Lubet RA. Celecoxib and difluoromethylornithine in combination have strong therapeutic activity against UV-induced skin tumors in mice. Carcinogenesis. 2003 May; 24(5):945-52. PMID: 12771040.
      Citations: 18     Fields:    Translation:AnimalsCells
    60. Fabris V, Lamb CA, Keck C, Aldaz CM, Merani S, Lanari C. Karyotypic evolution of four novel mouse mammary carcinoma cell lines. Identification of marker chromosomes by fluorescence in situ hybridization. Cancer Genet Cytogenet. 2003 Apr 01; 142(1):36-45. PMID: 12660031.
      Citations: 2     Fields:    Translation:AnimalsCells
    61. Hodges LC, Cook JD, Lobenhofer EK, Li L, Bennett L, Bushel PR, Aldaz CM, Afshari CA, Walker CL. Tamoxifen functions as a molecular agonist inducing cell cycle-associated genes in breast cancer cells. Mol Cancer Res. 2003 Feb; 1(4):300-11. PMID: 12612058.
      Citations: 39     Fields:    Translation:HumansCells
    62. Wang A, Gu J, Judson-Kremer K, Powell KL, Mistry H, Simhambhatla P, Aldaz CM, Gaddis S, MacLeod MC. Response of human mammary epithelial cells to DNA damage induced by BPDE: involvement of novel regulatory pathways. Carcinogenesis. 2003 Feb; 24(2):225-34. PMID: 12584171.
      Citations: 19     Fields:    Translation:HumansCells
    63. Ludes-Meyers JH, Bednarek AK, Popescu NC, Bedford M, Aldaz CM. WWOX, the common chromosomal fragile site, FRA16D, cancer gene. Cytogenet Genome Res. 2003; 100(1-4):101-10. PMID: 14526170.
      Citations: 35     Fields:    Translation:HumansCells
    64. Aldaz CM, Hu Y, Daniel R, Gaddis S, Kittrell F, Medina D. Serial analysis of gene expression in normal p53 null mammary epithelium. Oncogene. 2002 Sep 12; 21(41):6366-76. PMID: 12214277.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    65. Turner BC, Ottey M, Zimonjic DB, Potoczek M, Hauck WW, Pequignot E, Keck-Waggoner CL, Sevignani C, Aldaz CM, McCue PA, Palazzo J, Huebner K, Popescu NC. The fragile histidine triad/common chromosome fragile site 3B locus and repair-deficient cancers. Cancer Res. 2002 Jul 15; 62(14):4054-60. PMID: 12124341.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    66. Li JJ, Papa D, Davis MF, Weroha SJ, Aldaz CM, El-Bayoumy K, Ballenger J, Tawfik O, Li SA. Ploidy differences between hormone- and chemical carcinogen-induced rat mammary neoplasms: comparison to invasive human ductal breast cancer. Mol Carcinog. 2002 Jan; 33(1):56-65. PMID: 11807958.
      Citations: 24     Fields:    Translation:HumansAnimals
    67. Bednarek AK, Keck-Waggoner CL, Daniel RL, Laflin KJ, Bergsagel PL, Kiguchi K, Brenner AJ, Aldaz CM. WWOX, the FRA16D gene, behaves as a suppressor of tumor growth. Cancer Res. 2001 Nov 15; 61(22):8068-73. PMID: 11719429.
      Citations: 99     Fields:    Translation:HumansCells
    68. Charpentier AH, Bednarek AK, Daniel RL, Hawkins KA, Laflin KJ, Gaddis S, MacLeod MC, Aldaz CM. Effects of estrogen on global gene expression: identification of novel targets of estrogen action. Cancer Res. 2000 Nov 01; 60(21):5977-83. PMID: 11085516.
      Citations: 73     Fields:    Translation:HumansCells
    69. Bednarek AK, Laflin KJ, Daniel RL, Liao Q, Hawkins KA, Aldaz CM. WWOX, a novel WW domain-containing protein mapping to human chromosome 16q23.3-24.1, a region frequently affected in breast cancer. Cancer Res. 2000 Apr 15; 60(8):2140-5. PMID: 10786676.
      Citations: 155     Fields:    Translation:HumansCells
    70. Wang A, Pierce A, Judson-Kremer K, Gaddis S, Aldaz CM, Johnson DG, MacLeod MC. Rapid analysis of gene expression (RAGE) facilitates universal expression profiling. Nucleic Acids Res. 1999 Dec 01; 27(23):4609-18. PMID: 10556317.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    71. Bednarek A, Shilkaitis A, Green A, Lubet R, Kelloff G, Christov K, Aldaz CM. Suppression of cell proliferation and telomerase activity in 4-(hydroxyphenyl)retinamide-treated mammary tumors. Carcinogenesis. 1999 May; 20(5):879-83. PMID: 10334206.
      Citations: 5     Fields:    Translation:Animals
    72. Yu W, Israel K, Liao QY, Aldaz CM, Sanders BG, Kline K. Vitamin E succinate (VES) induces Fas sensitivity in human breast cancer cells: role for Mr 43,000 Fas in VES-triggered apoptosis. Cancer Res. 1999 Feb 15; 59(4):953-61. PMID: 10029090.
      Citations: 25     Fields:    Translation:HumansCells
    73. Cruz C, Paladugu A, Ventura F, Bartrons R, Aldaz CM, Rosa JL. Assignment of the human P532 gene (HERC1) to chromosome 15q22 by fluorescence in situ hybridization. Cytogenet Cell Genet. 1999; 86(1):68-9. PMID: 10516438.
      Citations: 2     Fields:    Translation:HumansCells
    74. Berton TR, Conti CJ, Mitchell DL, Aldaz CM, Lubet RA, Fischer SM. The effect of vitamin E acetate on ultraviolet-induced mouse skin carcinogenesis. Mol Carcinog. 1998 Nov; 23(3):175-84. PMID: 9833778.
      Citations: 15     Fields:    Translation:AnimalsCells
    75. Brenner AJ, Stampfer MR, Aldaz CM. Increased p16 expression with first senescence arrest in human mammary epithelial cells and extended growth capacity with p16 inactivation. Oncogene. 1998 Jul 16; 17(2):199-205. PMID: 9674704.
      Citations: 99     Fields:    Translation:HumansCells
    76. Bednarek AK, Chu Y, Aldaz CM. Constitutive telomerase activity in cells with tissue-renewing potential from estrogen-regulated rat tissues. Oncogene. 1998 Jan 22; 16(3):381-5. PMID: 9467963.
      Citations: 3     Fields:    Translation:Animals
    77. Bednarek AK, Chu Y, Slaga TJ, Aldaz CM. Telomerase and cell proliferation in mouse skin papillomas. Mol Carcinog. 1997 Dec; 20(4):329-31. PMID: 9433476.
      Citations: 5     Fields:    Translation:Animals
    78. McKenzie KE, Armstrong BA, Chen Y, Nagarajan M, Aldaz CM, Sukumar S. Alterations in the Ha-ras-1 and the p53 pathway genes in the progression of N-methyl-N-nitrosourea-induced rat mammary tumors. Mol Carcinog. 1997 Oct; 20(2):194-203. PMID: 9364209.
      Citations:    Fields:    Translation:AnimalsCells
    79. Bednarek AK, Sahin A, Brenner AJ, Johnston DA, Aldaz CM. Analysis of telomerase activity levels in breast cancer: positive detection at the in situ breast carcinoma stage. Clin Cancer Res. 1997 Jan; 3(1):11-6. PMID: 9815531.
      Citations: 12     Fields:    Translation:HumansCells
    80. Brenner AJ, Aldaz CM. The genetics of sporadic breast cancer. Prog Clin Biol Res. 1997; 396:63-82. PMID: 9108590.
      Citations: 4     Fields:    Translation:Humans
    81. Chen T, Sahin A, Aldaz CM. Deletion map of chromosome 16q in ductal carcinoma in situ of the breast: refining a putative tumor suppressor gene region. Cancer Res. 1996 Dec 15; 56(24):5605-9. PMID: 8971163.
      Citations: 31     Fields:    Translation:HumansCells
    82. Brenner AJ, Paladugu A, Wang H, Olopade OI, Dreyling MH, Aldaz CM. Preferential loss of expression of p16(INK4a) rather than p19(ARF) in breast cancer. Clin Cancer Res. 1996 Dec; 2(12):1993-8. PMID: 9816158.
      Citations: 11     Fields:    Translation:HumansCells
    83. Chen Y, McKenzie KE, Aldaz CM, Sukumar S. Midkine in the progression of rat N-nitroso-N-methylurea-induced mammary tumors. Mol Carcinog. 1996 Nov; 17(3):112-6. PMID: 8944070.
      Citations: 2     Fields:    Translation:AnimalsCells
    84. Aldaz CM, Liao QY, Paladugu A, Rehm S, Wang H. Allelotypic and cytogenetic characterization of chemically induced mouse mammary tumors: high frequency of chromosome 4 loss of heterozygosity at advanced stages of progression. Mol Carcinog. 1996 Nov; 17(3):126-33. PMID: 8944072.
      Citations: 7     Fields:    Translation:AnimalsCells
    85. Aldaz CM, Liao QY, LaBate M, Johnston DA. Medroxyprogesterone acetate accelerates the development and increases the incidence of mouse mammary tumors induced by dimethylbenzanthracene. Carcinogenesis. 1996 Sep; 17(9):2069-72. PMID: 8824536.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    86. Battalora MS, Conti CJ, Aldaz CM, Slaga TJ, Johnston DA, DiGiovanni J. Regression and progression characteristics of papillomas induced by chrysarobin in SENCAR mice. Carcinogenesis. 1996 May; 17(5):955-60. PMID: 8640943.
      Citations:    Fields:    Translation:Animals
    87. Slaga TJ, Budunova IV, Gimenez-Conti IB, Aldaz CM. The mouse skin carcinogenesis model. J Investig Dermatol Symp Proc. 1996 Apr; 1(2):151-6. PMID: 9627710.
      Citations: 8     Fields:    Translation:Animals
    88. Chen T, Dhingra K, Sahin A, Sneige N, Hortobagyi G, Aldaz CM. Technical approach for the study of the genetic evolution of breast cancer from paraffin-embedded tissue sections. Breast Cancer Res Treat. 1996; 39(2):177-85. PMID: 8872326.
      Citations: 3     Fields:    Translation:HumansCells
    89. Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. The role of p53 loss in genomic instability and tumor progression in a murine mammary cancer model. Prog Clin Biol Res. 1996; 395:1-11. PMID: 8895979.
      Citations: 7     Fields:    Translation:Animals
    90. Chen KS, Paladugu A, Aldaz CM, Gould MN. Cloning and chromosomal localization of the rat Stat5 and Yy1 genes. Cytogenet Cell Genet. 1996; 74(4):277-80. PMID: 8976384.
      Citations: 2     Fields:    Translation:AnimalsCells
    91. Bednarek A, Budunova I, Slaga TJ, Aldaz CM. Increased telomerase activity in mouse skin premalignant progression. Cancer Res. 1995 Oct 15; 55(20):4566-9. PMID: 7553630.
      Citations: 15     Fields:    Translation:AnimalsCells
    92. Aldaz CM, Chen T, Sahin A, Cunningham J, Bondy M. Comparative allelotype of in situ and invasive human breast cancer: high frequency of microsatellite instability in lobular breast carcinomas. Cancer Res. 1995 Sep 15; 55(18):3976-81. PMID: 7664266.
      Citations: 22     Fields:    Translation:HumansCells
    93. Brenner AJ, Aldaz CM. Chromosome 9p allelic loss and p16/CDKN2 in breast cancer and evidence of p16 inactivation in immortal breast epithelial cells. Cancer Res. 1995 Jul 01; 55(13):2892-5. PMID: 7796417.
      Citations: 24     Fields:    Translation:HumansCells
    94. Manni A, Grove R, Kunselman S, Aldaz CM. Involvement of the polyamine pathway in breast cancer progression. Cancer Lett. 1995 May 25; 92(1):49-57. PMID: 7757960.
      Citations: 12     Fields:    Translation:Animals
    95. Donehower LA, Godley LA, Aldaz CM, Pyle R, Shi YP, Pinkel D, Gray J, Bradley A, Medina D, Varmus HE. Deficiency of p53 accelerates mammary tumorigenesis in Wnt-1 transgenic mice and promotes chromosomal instability. Genes Dev. 1995 Apr 01; 9(7):882-95. PMID: 7705663.
      Citations: 76     Fields:    Translation:AnimalsCells
    96. Aldaz CM, Yeung RS, Latif F, Lerman MI, Xiao G, Trono D, Walker CL. Colocalization of the rat homolog of the von Hippel Lindau (Vhl) gene and the plasma membrane Ca++ transporting ATPase isoform 2 (Atp2b2) gene to rat chromosome bands 4q41.3-->42.1. Cytogenet Cell Genet. 1995; 71(3):253-6. PMID: 7587388.
      Citations:    Fields:    Translation:HumansAnimalsCells
    97. Gollahon LS, Chen A, Aldaz CM. Loss of heterozygosity at chromosome 1q loci in rat mammary tumors. Mol Carcinog. 1995 Jan; 12(1):7-13. PMID: 7818765.
      Citations: 4     Fields:    Translation:Animals
    98. Varmus HE, Godley LA, Roy S, Taylor IC, Yuschenkoff L, Shi YP, Pinkel D, Gray J, Pyle R, Aldaz CM, et al. Defining the steps in a multistep mouse model for mammary carcinogenesis. Cold Spring Harb Symp Quant Biol. 1994; 59:491-9. PMID: 7587104.
      Citations: 3     Fields:    Translation:HumansAnimals
    99. Aldaz CM, Gollahon LS, Chen A. Systematic HRAS amplification in ovary-independent mammary tumors: correlation with progressively anaplastic phenotypes. Cancer Res. 1993 Nov 15; 53(22):5339-44. PMID: 8221670.
      Citations: 1     Fields:    Translation:Animals
    100. DiGiovanni J, Walker SE, Aldaz CM, Slaga TJ, Conti CJ. Further studies on the influence of initiation dose on papilloma growth and progression during two-stage carcinogenesis in SENCAR mice. Carcinogenesis. 1993 Sep; 14(9):1831-6. PMID: 8403206.
      Citations: 1     Fields:    Translation:Animals
    101. Dhingra K, Vogel V, Sneige N, Sahin A, Aldaz CM, Hortobagyi GN, Hittelman W. Strategies for the application of biomarkers for risk assessment and efficacy in breast cancer chemoprevention trials. J Cell Biochem Suppl. 1993; 17G:37-43. PMID: 8007707.
      Citations:    Fields:    Translation:Humans
    102. Aldaz CM, Chen A, Gollahon LS, Russo J, Zappler K. Nonrandom abnormalities involving chromosome 1 and Harvey-ras-1 alleles in rat mammary tumor progression. Cancer Res. 1992 Sep 01; 52(17):4791-8. PMID: 1511443.
      Citations: 6     Fields:    Translation:AnimalsCells
    103. Gollahon LS, Aldaz CM. Chromosomal localization of the rat Harvey-ras-1 gene (HRAS) by in situ hybridization. Cytogenet Cell Genet. 1992; 61(2):123-4. PMID: 1395719.
      Citations: 2     Fields:    Translation:AnimalsCells
    104. Aldaz CM, Gollahon LS, Chen A. Chromosome alterations in rat mammary tumor progression. Prog Clin Biol Res. 1992; 376:137-53. PMID: 1528918.
      Citations: 2     Fields:    Translation:HumansAnimals
    105. Bianchi AB, Navone NM, Aldaz CM, Conti CJ. Overlapping loss of heterozygosity by mitotic recombination on mouse chromosome 7F1-ter in skin carcinogenesis. Proc Natl Acad Sci U S A. 1991 Sep 01; 88(17):7590-4. PMID: 1909026.
      Citations: 9     Fields:    Translation:AnimalsCells
    106. Aldaz CM, Conti CJ, Chen A, Bianchi A, Walker SB, DiGiovanni J. Promoter independence as a feature of most skin papillomas in SENCAR mice. Cancer Res. 1991 Feb 01; 51(3):1045-50. PMID: 1899044.
      Citations: 2     Fields:    Translation:Animals
    107. Chiba M, Aldaz CM, Conti CJ, Klein-Szanto AJ. Metastatic potential of mouse skin carcinomas produced by different protocols of chemical carcinogenesis. Invasion Metastasis. 1991; 11(5):288-96. PMID: 1686875.
      Citations: 1     Fields:    Translation:Animals
    108. Gimenez-Conti I, Aldaz CM, Bianchi AB, Roop DR, Slaga TJ, Conti CJ. Early expression of type I K13 keratin in the progression of mouse skin papillomas. Carcinogenesis. 1990 Nov; 11(11):1995-9. PMID: 1699681.
      Citations: 8     Fields:    Translation:Animals
    109. Bianchi AB, Aldaz CM, Conti CJ. Nonrandom duplication of the chromosome bearing a mutated Ha-ras-1 allele in mouse skin tumors. Proc Natl Acad Sci U S A. 1990 Sep; 87(17):6902-6. PMID: 1697691.
      Citations: 20     Fields:    Translation:AnimalsCells
    110. Miller DR, Viaje A, Rotstein J, Aldaz CM, Conti CJ, Slaga TJ. Induction of terminal differentiation-resistant epidermal cells in mouse skin and in papillomas by different initiators during two-stage carcinogenesis. Cancer Res. 1989 Jan 15; 49(2):410-4. PMID: 2491955.
      Citations: 1     Fields:    Translation:AnimalsCells
    111. Aldaz CM, Trono D, Larcher F, Slaga TJ, Conti CJ. Sequential trisomization of chromosomes 6 and 7 in mouse skin premalignant lesions. Mol Carcinog. 1989; 2(1):22-6. PMID: 2499343.
      Citations: 16     Fields:    Translation:Animals
    112. Aldaz CM, Conti CJ. The premalignant nature of mouse skin papillomas: histopathologic, cytogenetic, and biochemical evidence. Carcinog Compr Surv. 1989; 11:227-42. PMID: 2465820.
      Citations: 1     Fields:    Translation:Animals
    113. Aldaz CM, Conti CJ, Yuspa SH, Slaga TJ. Cytogenetic profile of mouse skin tumors induced by the viral Harvey-ras gene. Carcinogenesis. 1988 Aug; 9(8):1503-5. PMID: 3402048.
      Citations: 2     Fields:    Translation:Animals
    114. Aldaz CM, Conti CJ, Larcher F, Trono D, Roop DR, Chesner J, Whitehead T, Slaga TJ. Sequential development of aneuploidy, keratin modifications, and gamma-glutamyltransferase expression in mouse skin papillomas. Cancer Res. 1988 Jun 01; 48(11):3253-7. PMID: 2452689.
      Citations: 10     Fields:    Translation:Animals
    115. Conti CJ, Larcher F, Chesner J, Aldaz CM. Polyacrylamide gel electrophoresis and immunoblotting of proteins extracted from paraffin-embedded tissue sections. J Histochem Cytochem. 1988 May; 36(5):547-50. PMID: 3282007.
      Citations: 9     Fields:    Translation:Animals
    116. Aldaz CM, Conti CJ, Klein-Szanto AJ, Slaga TJ. Progressive dysplasia and aneuploidy are hallmarks of mouse skin papillomas: relevance to malignancy. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):2029-32. PMID: 3104907.
      Citations: 19     Fields:    Translation:AnimalsCells
    117. Miller DR, Viaje A, Aldaz CM, Conti CJ, Slaga TJ. Terminal differentiation-resistant epidermal cells in mice undergoing two-stage carcinogenesis. Cancer Res. 1987 Apr 01; 47(7):1935-40. PMID: 3815381.
      Citations: 9     Fields:    Translation:AnimalsCells
    118. Conti CJ, Aldaz CM, O'Connell J, Klein-Szanto AJ, Slaga TJ. Aneuploidy, an early event in mouse skin tumor development. Carcinogenesis. 1986 Nov; 7(11):1845-8. PMID: 3769132.
      Citations: 14     Fields:    Translation:Animals
    119. Conti CJ, Fries JW, Aldaz CM, Klein-Szanto AJ, Slaga TJ. Allogeneic transplantation of normal epidermal cells and squamous cell carcinomas in SENCAR mice. Environ Health Perspect. 1986 Sep; 68:125-9. PMID: 3536472.
      Citations:    Fields:    Translation:Animals
    120. Klein-Szanto AJ, Conti CJ, Aldaz CM, Clapp N, Nesnow S, Slaga TJ. Effects of chronic topical application of 12-O-tetradecanoylphorbol-13-acetate on the skin and internal organs of SENCAR mice. Environ Health Perspect. 1986 Sep; 68:75-80. PMID: 3780635.
      Citations: 1     Fields:    Translation:Animals
    121. Aldaz CM, Conti CJ, O'Connell J, Yuspa SH, Klein-Szanto AJ, Slaga TJ. Cytogenetic evidence for gene amplification in mouse skin carcinogenesis. Cancer Res. 1986 Jul; 46(7):3565-8. PMID: 3708588.
      Citations: 1     Fields:    Translation:Animals
    122. Aldaz CM, Conti CJ, Klein-Szanto AJ, Slaga TJ. A direct cytogenetic technique for mouse skin carcinomas and papillomas. Cancer Genet Cytogenet. 1986 Feb 15; 20(3-4):223-9. PMID: 3943063.
      Citations: 4     Fields:    Translation:Animals
    123. Slaga TJ, O'Connell J, Rotstein J, Patskan G, Morris R, Aldaz CM, Conti CJ. Critical genetic determinants and molecular events in multistage skin carcinogenesis. Symp Fundam Cancer Res. 1986; 39:31-44. PMID: 3321308.
      Citations: 5     Translation:HumansAnimals
    124. Aldaz CM, Conti CJ, Gimenez IB, Slaga TJ, Klein-Szanto AJ. Cutaneous changes during prolonged application of 12-O-tetradecanoylphorbol-13-acetate on mouse skin and residual effects after cessation of treatment. Cancer Res. 1985 Jun; 45(6):2753-9. PMID: 3986807.
      Citations: 6     Fields:    Translation:AnimalsCells
    125. Conti CJ, Gimenez de Conti IB, Tasat DR, Aldaz CM, Larcher F. Isolation, culture and immunohistochemical identification of vaginal epithelial cells. Cell Mol Biol. 1983; 29(6):501-7. PMID: 6197171.
      Citations:    Fields:    Translation:AnimalsCells
    126. Conti CJ, Aldaz CM, Giménez IB. A simple procedure for autoradiography of keratinocyte cultures. Stain Technol. 1982 Nov; 57(6):355-7. PMID: 7164124.
      Citations:    Fields:    Translation:HumansCells
    127. CSA-RRBS. 105-110.
    128. Karyotypic evolutions of cancer species in rats during the long latent periods after injection of nitrosourea. Molecular Cytogenetics. 7.
    129. Chromosomal abnormalities in mouse skin tumors induced by two stage carcinogenesis.
    130. Chromosomal and genetic abnormalities in models of epithelial carcinogenesis. Cancer Bulletin. 47:486-491.
    131. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 87:10068.
    132. Oncogene.
    133. Gene expression signature of estrogen receptor α status in breast cancer. BMC Genomics. 6.
    134. Impact of decitabine on immunohistochemistry expression of the putative tumor suppressor genes FHIT, WWOX, FUS1 and PTEN in clinical tumor samples. Clinical Epigenetics. 6.
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