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MACUS T KUO

TitleProfessor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address2130 W Holcombe Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Yan D, Aiba I, Chen HH, Kuo MT. Effects of Cu(II) and cisplatin on the stability of Specific protein 1 (Sp1)-DNA binding: Insights into the regulation of copper homeostasis and platinum drug transport. J Inorg Biochem. 2016 Aug; 161:37-9. PMID: 27172866; PMCID: PMC4912872 [Available on 08/01/17].
    2. Tsai WB, Long Y, Kuo MT. Gas6/Axl in arginine-starvation therapy. Oncoscience. 2015; 2(8):659-60. PMID: 26425646.
      View in: PubMed
    3. Chen HH, Chen WC, Liang ZD, Tsai WB, Long Y, Aiba I, Fu S, Broaddus R, Liu J, Feun LG, Savaraj N, Kuo MT. Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy. Expert Opin Ther Targets. 2015; 19(10):1307-17. PMID: 26004625.
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    4. Savaraj N, Wu C, Li YY, Wangpaichitr M, You M, Bomalaski J, He W, Kuo MT, Feun LG. Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin. Oncotarget. 2015 Mar 20; 6(8):6295-309. PMID: 25749046.
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    5. Feun LG, Kuo MT, Savaraj N. Arginine deprivation in cancer therapy. Curr Opin Clin Nutr Metab Care. 2015 Jan; 18(1):78-82. PMID: 25474015.
      View in: PubMed
    6. Fu S, Hou MM, Wheler J, Hong D, Naing A, Tsimberidou A, Janku F, Zinner R, Piha-Paul S, Falchook G, Kuo MT, Kurzrock R. Exploratory study of carboplatin plus the copper-lowering agent trientine in patients with advanced malignancies. Invest New Drugs. 2014 Jun; 32(3):465-72. PMID: 24306314.
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    7. Liang ZD, Long Y, Chen HH, Savaraj N, Kuo MT. Regulation of the high-affinity copper transporter (hCtr1) expression by cisplatin and heavy metals. J Biol Inorg Chem. 2014 Jan; 19(1):17-27. PMID: 24132751.
      View in: PubMed
    8. Chen HH, Kuo MT. Overcoming platinum drug resistance with copper-lowering agents. Anticancer Res. 2013 Oct; 33(10):4157-61. PMID: 24122978; PMCID: PMC4001922.
    9. Long Y, Tsai WB, Wangpaichitr M, Tsukamoto T, Savaraj N, Feun LG, Kuo MT. Arginine deiminase resistance in melanoma cells is associated with metabolic reprogramming, glucose dependence, and glutamine addiction. Mol Cancer Ther. 2013 Nov; 12(11):2581-90. PMID: 23979920; PMCID: PMC3839414.
    10. You M, Savaraj N, Kuo MT, Wangpaichitr M, Varona-Santos J, Wu C, Nguyen DM, Feun L. TRAIL induces autophagic protein cleavage through caspase activation in melanoma cell lines under arginine deprivation. Mol Cell Biochem. 2013 Feb; 374(1-2):181-90. PMID: 23180246; PMCID: PMC3771696.
    11. Kuo MT, Fu S, Savaraj N, Chen HH. Role of the human high-affinity copper transporter in copper homeostasis regulation and cisplatin sensitivity in cancer chemotherapy. Cancer Res. 2012 Sep 15; 72(18):4616-21. PMID: 22962276.
      View in: PubMed
    12. Liang ZD, Long Y, Tsai WB, Fu S, Kurzrock R, Gagea-Iurascu M, Zhang F, Chen HH, Hennessy BT, Mills GB, Savaraj N, Kuo MT. Mechanistic basis for overcoming platinum resistance using copper chelating agents. Mol Cancer Ther. 2012 Nov; 11(11):2483-94. PMID: 22914438; PMCID: PMC3496003.
    13. Feun LG, Marini A, Walker G, Elgart G, Moffat F, Rodgers SE, Wu CJ, You M, Wangpaichitr M, Kuo MT, Sisson W, Jungbluth AA, Bomalaski J, Savaraj N. Negative argininosuccinate synthetase expression in melanoma tumours may predict clinical benefit from arginine-depleting therapy with pegylated arginine deiminase. Br J Cancer. 2012 Apr 24; 106(9):1481-5. PMID: 22472884; PMCID: PMC3341859.
    14. Fu S, Naing A, Fu C, Kuo MT, Kurzrock R. Overcoming platinum resistance through the use of a copper-lowering agent. Mol Cancer Ther. 2012 Jun; 11(6):1221-5. PMID: 22491798.
      View in: PubMed
    15. Tsai WB, Aiba I, Long Y, Lin HK, Feun L, Savaraj N, Kuo MT. Activation of Ras/PI3K/ERK pathway induces c-Myc stabilization to upregulate argininosuccinate synthetase, leading to arginine deiminase resistance in melanoma cells. Cancer Res. 2012 May 15; 72(10):2622-33. PMID: 22461507; PMCID: PMC3433038.
    16. Wangpaichitr M, Sullivan EJ, Theodoropoulos G, Wu C, You M, Feun LG, Lampidis TJ, Kuo MT, Savaraj N. The relationship of thioredoxin-1 and cisplatin resistance: its impact on ROS and oxidative metabolism in lung cancer cells. Mol Cancer Ther. 2012 Mar; 11(3):604-15. PMID: 22248473.
      View in: PubMed
    17. Liang ZD, Tsai WB, Lee MY, Savaraj N, Kuo MT. Specificity protein 1 (sp1) oscillation is involved in copper homeostasis maintenance by regulating human high-affinity copper transporter 1 expression. Mol Pharmacol. 2012 Mar; 81(3):455-64. PMID: 22172574; PMCID: PMC3286298.
    18. Chen HH, Yan JJ, Chen WC, Kuo MT, Lai YH, Lai WW, Liu HS, Su WC. Predictive and prognostic value of human copper transporter 1 (hCtr1) in patients with stage III non-small-cell lung cancer receiving first-line platinum-based doublet chemotherapy. Lung Cancer. 2012 Feb; 75(2):228-34. PMID: 21788094; PMCID: PMC3319119.
    19. Chen HH, Kuo MT. Role of glutathione in the regulation of Cisplatin resistance in cancer chemotherapy. Met Based Drugs. 2010; 2010. PMID: 20885916.
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    20. Kuo MT, Savaraj N, Feun LG. Targeted cellular metabolism for cancer chemotherapy with recombinant arginine-degrading enzymes. Oncotarget. 2010 Aug; 1(4):246-51. PMID: 21152246.
      View in: PubMed
    21. Savaraj N, You M, Wu C, Wangpaichitr M, Kuo MT, Feun LG. Arginine deprivation, autophagy, apoptosis (AAA) for the treatment of melanoma. Curr Mol Med. 2010 Jun; 10(4):405-12. PMID: 20459375; PMCID: PMC3096550.
    22. You M, Savaraj N, Wangpaichitr M, Wu C, Kuo MT, Varona-Santos J, Nguyen DM, Feun L. The combination of ADI-PEG20 and TRAIL effectively increases cell death in melanoma cell lines. Biochem Biophys Res Commun. 2010 Apr 9; 394(3):760-6. PMID: 20227389; PMCID: PMC2860865.
    23. Guan X, Wang Y, Xie R, Chen L, Bai J, Lu J, Kuo MT. p27(Kip1) as a prognostic factor in breast cancer: a systematic review and meta-analysis. J Cell Mol Med. 2010 Apr; 14(4):944-53. PMID: 19298520.
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    24. Tsai WB, Aiba I, Lee SY, Feun L, Savaraj N, Kuo MT. Resistance to arginine deiminase treatment in melanoma cells is associated with induced argininosuccinate synthetase expression involving c-Myc/HIF-1alpha/Sp4. Mol Cancer Ther. 2009 Dec; 8(12):3223-33. PMID: 19934275; PMCID: PMC2795119.
    25. Liang ZD, Stockton D, Savaraj N, Tien Kuo M. Mechanistic comparison of human high-affinity copper transporter 1-mediated transport between copper ion and cisplatin. Mol Pharmacol. 2009 Oct; 76(4):843-53. PMID: 19570948.
      View in: PubMed
    26. Kuo MT. Redox regulation of multidrug resistance in cancer chemotherapy: molecular mechanisms and therapeutic opportunities. Antioxid Redox Signal. 2009 Jan; 11(1):99-133. PMID: 18699730.
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    27. Toyoda Y, Hagiya Y, Adachi T, Hoshijima K, Kuo MT, Ishikawa T. MRP class of human ATP binding cassette (ABC) transporters: historical background and new research directions. Xenobiotica. 2008 Jul; 38(7-8):833-62. PMID: 18668432.
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    28. Wangpaichitr M, Wu C, You M, Kuo MT, Feun L, Lampidis T, Savaraj N. Inhibition of mTOR restores cisplatin sensitivity through down-regulation of growth and anti-apoptotic proteins. Eur J Pharmacol. 2008 Sep 4; 591(1-3):124-7. PMID: 18585380.
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    29. Aiba I, Hossain A, Kuo MT. Elevated GSH level increases cadmium resistance through down-regulation of Sp1-dependent expression of the cadmium transporter ZIP8. Mol Pharmacol. 2008 Sep; 74(3):823-33. PMID: 18556457; PMCID: PMC2574563.
    30. Chen HH, Song IS, Hossain A, Choi MK, Yamane Y, Liang ZD, Lu J, Wu LY, Siddik ZH, Klomp LW, Savaraj N, Kuo MT. Elevated glutathione levels confer cellular sensitization to cisplatin toxicity by up-regulation of copper transporter hCtr1. Mol Pharmacol. 2008 Sep; 74(3):697-704. PMID: 18523133.
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    31. Song IS, Chen HH, Aiba I, Hossain A, Liang ZD, Klomp LW, Kuo MT. Transcription factor Sp1 plays an important role in the regulation of copper homeostasis in mammalian cells. Mol Pharmacol. 2008 Sep; 74(3):705-13. PMID: 18483225; PMCID: PMC2574735.
    32. Feun L, You M, Wu CJ, Kuo MT, Wangpaichitr M, Spector S, Savaraj N. Arginine deprivation as a targeted therapy for cancer. Curr Pharm Des. 2008; 14(11):1049-57. PMID: 18473854.
      View in: PubMed
    33. Kuo MT, Chen HH, Song IS, Savaraj N, Ishikawa T. The roles of copper transporters in cisplatin resistance. Cancer Metastasis Rev. 2007 Mar; 26(1):71-83. PMID: 17318448.
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    34. Adachi T, Nakagawa H, Chung I, Hagiya Y, Hoshijima K, Noguchi N, Kuo MT, Ishikawa T. Nrf2-dependent and -independent induction of ABC transporters ABCC1, ABCC2, and ABCG2 in HepG2 cells under oxidative stress. J Exp Ther Oncol. 2007; 6(4):335-48. PMID: 18038766.
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    35. Kuo MT. Roles of multidrug resistance genes in breast cancer chemoresistance. Adv Exp Med Biol. 2007; 608:23-30. PMID: 17993230.
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    36. Tien Kuo M, Savaraj N. Roles of reactive oxygen species in hepatocarcinogenesis and drug resistance gene expression in liver cancers. Mol Carcinog. 2006 Sep; 45(9):701-9. PMID: 16652372.
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    37. Hossain A, Kuo MT, Saunders GF. Mir-17-5p regulates breast cancer cell proliferation by inhibiting translation of AIB1 mRNA. Mol Cell Biol. 2006 Nov; 26(21):8191-201. PMID: 16940181; PMCID: PMC1636750.
    38. Hossain A, Nixon M, Kuo MT, Saunders GF. N-terminally truncated WT1 protein with oncogenic properties overexpressed in leukemia. J Biol Chem. 2006 Sep 22; 281(38):28122-30. PMID: 16698800.
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    39. Wei Y, Lin-Lee YC, Yang X, Dai W, Zhao S, Rassool FV, Elgart GW, Feun L, Savaraj N, Kuo MT. Molecular cloning of Chinese hamster 1q31 chromosomal fragile site DNA that is important to mdr1 gene amplification reveals a novel gene whose expression is associated with spermatocyte and adipocyte differentiation. Gene. 2006 May 10; 372:44-52. PMID: 16545529.
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    40. Kuo MT, Wei Y, Yang X, Tatebe S, Liu J, Troncoso P, Sahin A, Ro JY, Hamilton SR, Savaraj N. Association of fragile site-associated (FSA) gene expression with epithelial differentiation and tumor development. Biochem Biophys Res Commun. 2006 Feb 17; 340(3):887-93. PMID: 16386706.
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    41. Wu C, Wangpaichitr M, Feun L, Kuo MT, Robles C, Lampidis T, Savaraj N. Overcoming cisplatin resistance by mTOR inhibitor in lung cancer. Mol Cancer. 2005; 4(1):25. PMID: 16033649; PMCID: PMC1181826.
    42. Song IS, Tatebe S, Dai W, Kuo MT. Delayed mechanism for induction of gamma-glutamylcysteine synthetase heavy subunit mRNA stability by oxidative stress involving p38 mitogen-activated protein kinase signaling. J Biol Chem. 2005 Aug 5; 280(31):28230-40. PMID: 15946948.
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    43. Savaraj N, Wei Y, Unate H, Liu PM, Wu CJ, Wangpaichitr M, Xia D, Xu HJ, Hu SX, Tien Kuo M. Redox regulation of matrix metalloproteinase gene family in small cell lung cancer cells. Free Radic Res. 2005 Apr; 39(4):373-81. PMID: 16032782.
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    44. Savaraj N, Wu C, Landy H, Wangpaijit M, Wei Y, Kuo MT, Robles C, Furst AJ, Lampidis T, Feun L. Procollagen alpha 1 type 1: a potential aide in histopathological grading of glioma. Cancer Invest. 2005; 23(7):577-81. PMID: 16305983.
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    45. Song IS, Savaraj N, Siddik ZH, Liu P, Wei Y, Wu CJ, Kuo MT. Role of human copper transporter Ctr1 in the transport of platinum-based antitumor agents in cisplatin-sensitive and cisplatin-resistant cells. Mol Cancer Ther. 2004 Dec; 3(12):1543-9. PMID: 15634647.
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    46. Takayanagi S, Kataoka T, Ohara O, Oishi M, Kuo MT, Ishikawa T. Human ATP-binding cassette transporter ABCC10: expression profile and p53-dependent upregulation. J Exp Ther Oncol. 2004 Oct; 4(3):239-46. PMID: 15724843.
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    47. Savaraj N, Wu C, Wangpaichitr M, Kuo MT, Lampidis T, Robles C, Furst AJ, Feun L. Overexpression of mutated MRP4 in cisplatin resistant small cell lung cancer cell line: collateral sensitivity to azidothymidine. Int J Oncol. 2003 Jul; 23(1):173-9. PMID: 12792791.
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    48. Sun Y, Tang XM, Half E, Kuo MT, Sinicrope FA. Cyclooxygenase-2 overexpression reduces apoptotic susceptibility by inhibiting the cytochrome c-dependent apoptotic pathway in human colon cancer cells. Cancer Res. 2002 Nov 1; 62(21):6323-8. PMID: 12414664.
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    49. Tang X, Sun YJ, Half E, Kuo MT, Sinicrope F. Cyclooxygenase-2 overexpression inhibits death receptor 5 expression and confers resistance to tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in human colon cancer cells. Cancer Res. 2002 Sep 1; 62(17):4903-8. PMID: 12208739.
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    50. Lin-Lee YC, Nakamura S, Gandhi V, Curley SA, Stüber D, Burkot TR, Kuo MT. Prolonged stability and sustained prodrug cell killing activity using receptor-mediated delivery of malarial circumsporozoite-cytosine deaminase fusion protein into liver cancer cells. Mol Cancer Ther. 2002 May; 1(7):461-7. PMID: 12479264.
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    51. Kuo MT, Liu Z, Wei Y, Lin-Lee YC, Tatebe S, Mills GB, Unate H. Induction of human MDR1 gene expression by 2-acetylaminofluorene is mediated by effectors of the phosphoinositide 3-kinase pathway that activate NF-kappaB signaling. Oncogene. 2002 Mar 27; 21(13):1945-54. PMID: 11960367.
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    52. Tatebe S, Sinicrope FA, Kuo MT. Induction of multidrug resistance proteins MRP1 and MRP3 and gamma-glutamylcysteine synthetase gene expression by nonsteroidal anti-inflammatory drugs in human colon cancer cells. Biochem Biophys Res Commun. 2002 Feb 8; 290(5):1427-33. PMID: 11820781.
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    53. Gotsman I, Israeli D, Alper R, Rabbani E, Engelhardt D, Ilan Y. Induction of immune tolerance toward tumor-associated-antigens enables growth of human hepatoma in mice. Int J Cancer. 2002 Jan 1; 97(1):52-7. PMID: 11774243.
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    54. Deng L, Tatebe S, Lin-Lee YC, Ishikawa T, Kuo MT. MDR and MRP gene families as cellular determinant factors for resistance to clinical anticancer agents. Cancer Treat Res. 2002; 112:49-66. PMID: 12481711.
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    55. Tatebe S, Unate H, Sinicrope FA, Sakatani T, Sugamura K, Makino M, Ito H, Savaraj N, Kaibara N, Kuo MT. Expression of heavy subunit of gamma-glutamylcysteine synthetase (gamma-GCSh) in human colorectal carcinoma. Int J Cancer. 2002 Jan 1; 97(1):21-7. PMID: 11774239.
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    56. Lin-Lee YC, Tatebe S, Savaraj N, Ishikawa T, Tien Kuo M. Differential sensitivities of the MRP gene family and gamma-glutamylcysteine synthetase to prooxidants in human colorectal carcinoma cell lines with different p53 status. Biochem Pharmacol. 2001 Mar 1; 61(5):555-63. PMID: 11239498.
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    57. Deng L, Lin-Lee YC, Claret FX, Kuo MT. 2-acetylaminofluorene up-regulates rat mdr1b expression through generating reactive oxygen species that activate NF-kappa B pathway. J Biol Chem. 2001 Jan 5; 276(1):413-20. PMID: 11020383.
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    58. Ikegami Y, Tatebe S, Lin-Lee YC, Xie QW, Ishikawa T, Kuo MT. Induction of MRP1 and gamma-glutamylcysteine synthetase gene expression by interleukin 1beta is mediated by nitric oxide-related signalings in human colorectal cancer cells. J Cell Physiol. 2000 Nov; 185(2):293-301. PMID: 11025451.
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    59. Kuo MT, Chen CM, Lin CH, Fang HC, Lee CH. Surveys of volatile organic compounds in soil and groundwater at industrial sites in Taiwan. Bull Environ Contam Toxicol. 2000 Nov; 65(5):654-9. PMID: 11014851.
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    60. Bao JJ, Lee BP, Stephens LC, Sahin AA, Van NT, Johnston DA, Ou CN, Kuo MT. Elevated expression of hepatic proliferative markers during early hepatocarcinogenesis in hepatitis-B virus transgenic mice lacking mdr1a-encoded P-glycoprotein. Mol Carcinog. 2000 Oct; 29(2):103-11. PMID: 11074607.
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    61. Ishikawa T, Kuo MT, Furuta K, Suzuki M. The human multidrug resistance-associated protein (MRP) gene family: from biological function to drug molecular design. Clin Chem Lab Med. 2000 Sep; 38(9):893-7. PMID: 11097346.
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    62. Manna SK, Kuo MT, Aggarwal BB. Overexpression of gamma-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1. Oncogene. 1999 Jul 29; 18(30):4371-82. PMID: 10439045.
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    63. Yamane Y, Furuichi M, Song R, Van NT, Mulcahy RT, Ishikawa T, Kuo MT. Expression of multidrug resistance protein/GS-X pump and gamma-glutamylcysteine synthetase genes is regulated by oxidative stress. J Biol Chem. 1998 Nov 20; 273(47):31075-85. PMID: 9813007.
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    64. Ishikawa T, Kuo MT, Furuta K, Suzuki M. A new aspect on glutathione-associated biological function of MRP/GS-X pump and its gene expression. Cytotechnology. 1998 Sep; 27(1-3):81-93. PMID: 19002785; PMCID: PMC3449568.
    65. Kuo MT, Sen S, Hittelman WN, Hsu TC. Chromosomal fragile sites and DNA amplification in drug-resistant cells. Biochem Pharmacol. 1998 Jul 1; 56(1):7-13. PMID: 9698083.
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    66. Priebe W, Krawczyk M, Kuo MT, Yamane Y, Savaraj N, Ishikawa T. Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem Biophys Res Commun. 1998 Jun 29; 247(3):859-63. PMID: 9647783.
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    67. Zhou G, Kuo MT. Wild-type p53-mediated induction of rat mdr1b expression by the anticancer drug daunorubicin. J Biol Chem. 1998 Jun 19; 273(25):15387-94. PMID: 9624121.
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    68. Kuo MT, Bao J, Furuichi M, Yamane Y, Gomi A, Savaraj N, Masuzawa T, Ishikawa T. Frequent coexpression of MRP/GS-X pump and gamma-glutamylcysteine synthetase mRNA in drug-resistant cells, untreated tumor cells, and normal mouse tissues. Biochem Pharmacol. 1998 Mar 1; 55(5):605-15. PMID: 9515571.
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    69. Gomi A, Shinoda S, Masuzawa T, Ishikawa T, Kuo MT. Transient induction of the MRP/GS-X pump and gamma-glutamylcysteine synthetase by 1-(4-amino-2-methyl-5-pyrimidinyl)methyl-3-(2-chloroethyl)-3- nitrosourea in human glioma cells. Cancer Res. 1997 Dec 1; 57(23):5292-9. PMID: 9393752.
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    70. Gomi A, Masuzawa T, Ishikawa T, Kuo MT. Posttranscriptional regulation of MRP/GS-X pump and gamma-glutamylcysteine synthetase expression by 1-(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea and by cycloheximide in human glioma cells. Biochem Biophys Res Commun. 1997 Oct 9; 239(1):51-6. PMID: 9345268.
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    71. Zhou G, Kuo MT. NF-kappaB-mediated induction of mdr1b expression by insulin in rat hepatoma cells. J Biol Chem. 1997 Jun 13; 272(24):15174-83. PMID: 9182539.
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    72. Wegner CC, Zhou X, Ding ZM, Kuo MT, Carson DD. Tyrosine kinase inhibition decreases Muc-1 expression in mouse epithelial cells. J Cell Physiol. 1997 Feb; 170(2):200-8. PMID: 9009149.
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    73. Zhou G, Song R, Kuo MT. A novel cis-acting element is involved in the promoter activity of the rat mdr1b gene. Cell Growth Differ. 1996 Oct; 7(10):1369-81. PMID: 8891341.
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    74. Kuo MT, Bao JJ, Curley SA, Ikeguchi M, Johnston DA, Ishikawa T. Frequent coordinated overexpression of the MRP/GS-X pump and gamma-glutamylcysteine synthetase genes in human colorectal cancers. Cancer Res. 1996 Aug 15; 56(16):3642-4. PMID: 8705999.
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    75. Ishikawa T, Bao JJ, Yamane Y, Akimaru K, Frindrich K, Wright CD, Kuo MT. Coordinated induction of MRP/GS-X pump and gamma-glutamylcysteine synthetase by heavy metals in human leukemia cells. J Biol Chem. 1996 Jun 21; 271(25):14981-8. PMID: 8663001.
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    76. Broxterman HJ, Heijn M, Lankelma J. Re: How does the MRP/GS-X pump export doxorubicin? J Natl Cancer Inst. 1996 Apr 3; 88(7):466-8. PMID: 8618244.
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    77. Bao JJ, Zhang WW, Kuo MT. Adenoviral delivery of recombinant DNA into transgenic mice bearing hepatocellular carcinomas. Hum Gene Ther. 1996 Feb 10; 7(3):355-65. PMID: 8835222.
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    78. Akimaru K, Kuo MT, Furuta K, Suzuki M, Noyori R, Ishikawa T. Induction of MRP/GS-X pump and cellular resistance to anticancer prostaglandins. Cytotechnology. 1996; 19(3):221-7. PMID: 8862010.
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    79. Leach RJ, Banga SS, Ben-Othame K, Chughtai S, Clarke R, Daiger SP, Kolehmainen J, Kumar S, Kuo M, Macoska J, Mada N, Naylor SL, Nunes M, O'Connell P, Pebusque MJ, Pekkel V, Porter CJ, Simons CT, Sohocki MM, Trapman J, Wells D, Westbrook C, Wood S. Report of the Third International Workshop on Human Chromosome 8 Mapping. San Antonio, Texas, October 25-27, 1996. Cytogenet Cell Genet. 1996; 75(2-3):71-84. PMID: 9040775.
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    80. Ishikawa T, Akimaru K, Kuo MT, Priebe W, Suzuki M. How does the MRP/GS-X pump export doxorubicin? J Natl Cancer Inst. 1995 Nov 1; 87(21):1639-40. PMID: 7563208.
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    81. Song R, Ikeguchi M, Zhou G, Kuo MT. Identification and characterization of a hepatoma cell-specific enhancer in the mouse multidrug resistance mdr1b promoter. J Biol Chem. 1995 Oct 27; 270(43):25468-74. PMID: 7592715.
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    82. Yamaguchi Y, Kuo MT. Functional analysis of aryl hydrocarbon receptor nuclear translocator interactions with aryl hydrocarbon receptor in the yeast two-hybrid system. Biochem Pharmacol. 1995 Oct 12; 50(8):1295-302. PMID: 7488247.
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    83. Kuo MT, Julian J, Husain F, Song R, Carson DD. Regulation of multidrug resistance gene mdr1b/mdr1 expression in isolated mouse uterine epithelial cells. J Cell Physiol. 1995 Jul; 164(1):132-41. PMID: 7790384.
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    84. Ding ZM, Cristiano RJ, Roth JA, Takacs B, Kuo MT. Malarial circumsporozoite protein is a novel gene delivery vehicle to primary hepatocyte cultures and cultured cells. J Biol Chem. 1995 Feb 24; 270(8):3667-76. PMID: 7533154.
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    85. Curley SA, Newman RA, Dougherty TB, Fuhrman GM, Stone DL, Mikolajek JA, Guercio S, Guercio A, Carrasco CH, Kuo MT, et al. Complete hepatic venous isolation and extracorporeal chemofiltration as treatment for human hepatocellular carcinoma: a phase I study. Ann Surg Oncol. 1994 Sep; 1(5):389-99. PMID: 7850540.
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    86. Zhao JY, Savaraj N, Song R, Priebe W, Kuo MT. Overexpression of P-glycoprotein but not its mRNA in multidrug resistant cells selected with hydroxyrubicin. Anticancer Res. 1994 Sep-Oct; 14(5A):1735-42. PMID: 7531410.
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    87. Kuo MT, Vyas RC, Jiang LX, Hittelman WN. Chromosome breakage at a major fragile site associated with P-glycoprotein gene amplification in multidrug-resistant CHO cells. Mol Cell Biol. 1994 Aug; 14(8):5202-11. PMID: 7913517.
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    88. Kimura O, Yamaguchi Y, Gunning KB, Teeter LD, Husain F, Kuo MT. Retroviral delivery of DNA into the livers of transgenic mice bearing premalignant and malignant hepatocellular carcinomas. Hum Gene Ther. 1994 Jul; 5(7):845-52. PMID: 7981309.
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    89. Savaraj N, Lampidis TJ, Zhao JY, Wu CJ, Teeter LD, Kuo MT. Two multidrug-resistant Friend leukemic cell lines selected with different drugs exhibit overproduction of different P-glycoproteins. Cancer Invest. 1994; 12(2):138-44. PMID: 7907527.
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    90. Zhao JY, Ikeguchi M, Eckersberg T, Kuo MT. Modulation of multidrug resistance gene expression by dexamethasone in cultured hepatoma cells. Endocrinology. 1993 Aug; 133(2):521-8. PMID: 8102093.
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    91. Kuo MT. Expression of multidrug-resistance (P-glycoprotein) genes in liver cancers: a molecular example of the convergence theory of hepatocarcinogenesis? Mol Carcinog. 1993; 7(2):73-5. PMID: 8096140.
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    92. Teeter LD, Estes M, Chan JY, Atassi H, Sell S, Becker FF, Kuo MT. Activation of distinct multidrug-resistance (P-glycoprotein) genes during rat liver regeneration and hepatocarcinogenesis. Mol Carcinog. 1993; 8(2):67-73. PMID: 8104413.
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    93. Kuo MT, Zhao JY, Teeter LD, Ikeguchi M, Chisari FV. Activation of multidrug resistance (P-glycoprotein) mdr3/mdr1a gene during the development of hepatocellular carcinoma in hepatitis B virus transgenic mice. Cell Growth Differ. 1992 Aug; 3(8):531-40. PMID: 1356418.
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    94. Dutt A, Priebe TS, Teeter LD, Kuo MT, Nelson JA. Postnatal development of organic cation transport and mdr gene expression in mouse kidney. J Pharmacol Exp Ther. 1992 Jun; 261(3):1222-30. PMID: 1351097.
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    95. Zou CP, Van NT, Kuo MT. Isolation and characterization of putative intrinsic multidrug resistant Chinese hamster ovary cells by fluorescence activated cell sorting. Anticancer Res. 1992 Mar-Apr; 12(2):427-32. PMID: 1349795.
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    96. Ikeguchi M, Teeter LD, Eckersberg T, Ganapathi R, Kuo MT. Structural and functional analyses of the promoter of the murine multidrug resistance gene mdr3/mdr1a reveal a negative element containing the AP-1 binding site. DNA Cell Biol. 1991 Nov; 10(9):639-49. PMID: 1684503.
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    97. Teeter LD, Eckersberg T, Tsai Y, Kuo MT. Analysis of the Chinese hamster P-glycoprotein/multidrug resistance gene pgp1 reveals that the AP-1 site is essential for full promoter activity. Cell Growth Differ. 1991 Sep; 2(9):429-37. PMID: 1661134.
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    98. Teeter LD, Petersen DD, Nebert DW, Kuo MT. Murine mdr-1, mdr-2, and mdr-3 gene expression: no coinduction with the Cyp1a-1 and Nmo-1 genes in liver by 2,3,7,8-tetrachlorodibenzo-p-dioxin. DNA Cell Biol. 1991 Jul-Aug; 10(6):433-41. PMID: 2069718.
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    99. Teeter LD, Chan JY, Kuo MT. Coordinate activation of multidrug-resistance (P-glycoprotein) genes mdr2 and mdr3 during mouse liver regeneration. Mol Carcinog. 1991; 4(5):358-61. PMID: 1680339.
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    100. Ganapathi R, Kuo T, Teeter L, Grabowski D, Ford J. Relationship between expression of P-glycoprotein and efficacy of trifluoperazine in multidrug-resistant cells. Mol Pharmacol. 1991 Jan; 39(1):1-8. PMID: 1670962.
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    101. Teeter LD, Becker FF, Chisari FV, Li DJ, Kuo MT. Overexpression of the multidrug resistance gene mdr3 in spontaneous and chemically induced mouse hepatocellular carcinomas. Mol Cell Biol. 1990 Nov; 10(11):5728-35. PMID: 2122232; PMCID: PMC361344.
    102. Sen S, Hittelman WN, Teeter LD, Kuo MT. Model for the formation of double minutes from prematurely condensed chromosomes of replicating micronuclei in drug-treated Chinese hamster ovary cells undergoing DNA amplification. Cancer Res. 1989 Dec 1; 49(23):6731-7. PMID: 2819718.
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    103. Mukhopadhyay T, Kuo MT. Expression of the P-glycoprotein gene in multidrug-resistant Chinese hamster ovary cells. Anticancer Res. 1989 May-Jun; 9(3):575-8. PMID: 2569855.
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    104. Kacinski BM, Yee LD, Carter D, Li D, Kuo MT. Human breast carcinoma cell levels of MDR-1 (P-glycoprotein) transcripts correlate in vivo inversely and reciprocally with tumor progesterone receptor content. Cancer Commun. 1989; 1(1):1-6. PMID: 2576982.
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    105. Mukhopadhyay T, Batsakis JG, Kuo MT. Expression of the mdr (P-glycoprotein) gene in Chinese hamster digestive tracts. J Natl Cancer Inst. 1988 Apr 20; 80(4):269-75. PMID: 2895190.
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    106. Sun YL, Pao CI, Sen S, Kuo T. High-resolution mapping of DNase I hypersensitive site in the chicken beta-tubulin gene transfected into monkey cells. J Biol Chem. 1987 Jun 5; 262(16):7764-9. PMID: 3584140.
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    107. Sen S, Teeter LD, Kuo T. Specific gene amplification associated with consistent chromosomal abnormality in independently established multidrug-resistant Chinese hamster ovary cells. Chromosoma. 1987; 95(2):117-25. PMID: 3595311.
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    108. Dekmezian R, Chen X, Kuo T, Ordóñez N, Katz RL. DNA hybridization for human papillomavirus (HPV) in cervical lesions. Relationship of the presence of various viral subtypes to expression of HPV structural proteins, involucrin, and carcinoembryonic antigen. Arch Pathol Lab Med. 1987 Jan; 111(1):22-7. PMID: 3026279.
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    109. Teeter LD, Sanford JA, Sen S, Stallings RL, Siciliano MJ, Kuo MT. Multidrug-resistant phenotype cosegregates with an amplified gene in somatic cell hybrids of drug-resistant Chinese hamster ovary cells and drug-sensitive murine cells. Mol Cell Biol. 1986 Dec; 6(12):4268-73. PMID: 3796603; PMCID: PMC367208.
    110. Teeter LD, Atsumi S, Sen S, Kuo T. DNA amplification in multidrug, cross-resistant Chinese hamster ovary cells: molecular characterization and cytogenetic localization of the amplified DNA. J Cell Biol. 1986 Oct; 103(4):1159-66. PMID: 3771630.
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    111. Sen S, Siciliano MJ, Johnston DA, Schwartz RJ, Kuo T. The expression and chromatin structure of the chicken glyceraldehyde-3-phosphate dehydrogenase gene in mouse cells. J Biol Chem. 1985 Mar 10; 260(5):3071-8. PMID: 3972817.
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    112. Kuo MT, Plunkett W. Nick-translation of metaphase chromosomes: in vitro labeling of nuclease-hypersensitive regions in chromosomes. Proc Natl Acad Sci U S A. 1985 Feb; 82(3):854-8. PMID: 3856236; PMCID: PMC397145.
    113. Kuo MT, Sen S, Teeter L, Cailleau RM, Knesek JE, Bowen J. Expression of endogenous murine leukemia virus in transplantable tumor cells and DNA methylation of the viral sequences. Cancer Res. 1984 Aug; 44(8):3518-21. PMID: 6331650.
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    114. Kuo MT, Iyer B, Wu JR, Lapeyre JN, Becker FF. Methylation of the alpha-fetoprotein gene in productive and nonproductive rat hepatocellular carcinomas. Cancer Res. 1984 Apr; 44(4):1642-7. PMID: 6200217.
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    115. Li S, Meistrich ML, Brock WA, Hsu TC, Kuo MT. Isolation and preliminary characterization of the synaptonemal complex from rat pachytene spermatocytes. Exp Cell Res. 1983 Mar; 144(1):63-72. PMID: 6840213.
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    116. Kuo MT, Iyer B, Schwarz RJ. Condensation of chromatin into chromosomes preserves an open configuration but alters the DNase I hypersensitive cleavage sites of the transcribed gene. Nucleic Acids Res. 1982 Aug 11; 10(15):4565-79. PMID: 6215624; PMCID: PMC321112.
    117. Kuo MT. Analysis of DNA attached to the chromosome scaffold. J Cell Biol. 1982 May; 93(2):278-84. PMID: 6284767; PMCID: PMC2112844.
    118. Kuo MT. Comparison of chromosomal structures isolated under different conditions. Exp Cell Res. 1982 Mar; 138(1):221-9. PMID: 7067738.
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    119. Kuo MT. Distribution of tightly bound proteins in the chicken ovalbumin gene region. Biochemistry. 1982 Jan 19; 21(2):321-6. PMID: 6896157.
      View in: PubMed
    120. Kuo MT. Altered gel electrophoretic mobility of bleomycin-mediated release of nucleosomal DNA. Cancer Res. 1981 Jun; 41(6):2433-8. PMID: 6165461.
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    121. Kuo MT. Preferential damage of active chromatin by bleomycin. Cancer Res. 1981 Jun; 41(6):2439-43. PMID: 6165462.
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    122. Kuo MT. Studies in heterochromatin DNA: accessibility of late replicating heterochromatin DNA in chromatin to micrococcal nuclease digestion. Chromosoma. 1979 Jan 8; 70(2):183-94. PMID: 428268.
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    123. Tien Kuo M, Hsu TC. Biochemical and cytological studies of bleomycin actions on chromatin and chromosomes. Chromosoma. 1978 Sep 1; 68(3):229-40. PMID: 80313.
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    124. Kuo MT, Samy TS. Effects of neocarzinostatin on mammalian nuclei: release of nucleosomes. Biochim Biophys Acta. 1978 Mar 29; 518(1):186-90. PMID: 147106.
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    125. Kuo MT, Hsu TC. Studies in heterochromatin DNA: characterization of transcripts synthesized in situ from C-banded preparations. Chromosoma. 1978 Feb 24; 65(4):325-34. PMID: 648279.
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    126. Kuo MT, Hsu TC. Bleomycin causes release of nucleosomes from chromatin and chromosomes. Nature. 1978 Jan 5; 271(5640):83-4. PMID: 75507.
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    127. Hazen MW, Kuo MT, Arrighi FE. Genome analysis of Peromyscus (Rodentia, Cricetidae) VII. Localization of satellite DNA sequences and cytoplasmic poly(A) RNA sequences of P. eremicus on metaphase chromosomes. Chromosoma. 1977 Nov 14; 64(2):133-42. PMID: 562738.
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    128. Kuo MT, Saunders GF. Location of messenger specifying sequences in mammalian chromosomes. Chromosoma. 1977 Sep 27; 63(3):241-52. PMID: 561679.
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    129. Yunis JJ, Kuo MT, Saunders GF. Localization of sequences specifying messenger RNA to light-staining G-bands of human chromosomes. Chromosoma. 1977 Jun 23; 61(4):335-44. PMID: 880841.
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    130. Kuo MT, Auger LT, Saunders GF, Haidle CW. Effect of bleomycin on the synthesis and function of RNA. Cancer Res. 1977 May; 37(5):1345-8. PMID: 66980.
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    131. Kuo MT, Ried ME, Saunders GF. Abundancy and diversity of mRNA sequences in human leukocytes. Differentiation. 1976 Jun 4; 5(2-3):175-8. PMID: 1067212.
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    132. Tien Kuo M, Sahasrabuddhe CG, Saunders GF. Presence of messenger specifying sequences in the DNA of chromatin subunits. Proc Natl Acad Sci U S A. 1976 May; 73(5):1572-5. PMID: 1064026; PMCID: PMC430340.
    133. Kuo MT, Meinke W, Saunders GF. Localization of cytoplasmic-membrane-associated DNA in human chromosomes. Proc Natl Acad Sci U S A. 1975 Dec; 72(12):5004-6. PMID: 1061086; PMCID: PMC388863.
    134. Kuo MT, Hsu TC, Saunders GF. In situ RNA synthesis in fixed mammalian chromosomes. Exp Cell Res. 1974 Oct; 88(2):424-7. PMID: 4609783.
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    135. Tien Kuo M, Haidle CW, Inners LD. Characterization of bleomycin-resistant DNA. Biophys J. 1973 Dec; 13(12):1296-306. PMID: 4128368; PMCID: PMC1484354.
    136. Haidle CW, Kuo MT, Weiss KK. Nucleic acid--specificity of bleomycin. Biochem Pharmacol. 1972 Dec 15; 21(24):3308-12. PMID: 4119299.
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    137. Haidle CW, Weiss KK, Kuo MT. Release of free bases from deoxyribonucleic acid after reaction with bleomycin. Mol Pharmacol. 1972 Sep; 8(5):531-7. PMID: 4117297.
      View in: PubMed
    138. Expression of multidrug resistance (P-glycoprotein) MDR1 and MDR2 genes in human hepatocellular carcinomas and liver metastases of colonic tumors. International Journal of Oncology. 2:73-80.
    139. Targeting argininosuccinate synthetase negative melanomas using combination of arginine degrading enzyme and cisplatin. Oncotarget. 6:6295-6309.
    140. Targeting drug transport mechanisms for improving platinum-based cancer chemotherapy. Expert Opinion on Therapeutic Targets. 19:1307-1317.
    141. Gas6/Axl is the sensor of arginine-auxotrophic response in targeted chemotherapy with arginine-depleting agents. Oncogene.
    142. Targeting argininosuccinate synthetase in cancer therapy. 37-51.
    143. Characterization of chain breakage in DNA induced by bleomycin. BBA Section Nucleic Acids And Protein Synthesis. 335:109-114.
    144. Molecular design of glutathione-derived biochemical probes targeting the GS-X pump. Tetrahedron. 55:7529-7540.
    145. Arginine Deiminase and Cancer Therapy. 199-217.
    146. Actions of antitumor drug bleomycin on chromatin structure. 139.
    147. Gas6/Axl in arginine-starvation therapy. Oncoscience. 2:659-660.
    148. Molecular aspects. 243-277.
    149. C-Jun N-terminal kinase signalling pathway in response to cisplatin. Journal of Cellular and Molecular Medicine. 20:2013-2019.
    150. Cisplatin-induced synthetic lethality to arginine-starvation therapy by transcriptional suppression of ASS1 is regulated by DEC1, HIF-1α, and c-Myc transcription network and is independent of ASS1 promoter DNA methylation. Oncotarget. 7:82658-82670.
    151. BRAF inhibitor resistance enhances vulnerability to arginine deprivation in melanoma. Oncotarget. 7:17665-17680.
    152. Inhibition of protein synthesis by bleomycin in a cell free system from wheat germ embryo. Federation Proceedings. 35.
    153. Journal of Gastroenterology and Hepatology. 8:S17-S20.
    154. Dissolution of mammalian chromosomes and preferential euchromatin damage induced by bleomycin. Journal of Cell Biology. 67.
    155. Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. Cancer Letters. 388:54-63.
    156. Development and progression of human colon cancer. Cancer Bulletin. 44:321-326.
    157. Effects of Cu(II) and cisplatin on the stability of Specific protein 1 (Sp1)-DNA binding. Journal of Inorganic Biochemistry. 161:37-39.
    158. Actions of antitumor drug bleomycin on chromatin structure. Pharmacologist. 23.
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