InstitutionMD Anderson
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Soundararajan R, Viscuse P, Pilie P, Liu J, Logotheti S, Laberiano Fernández C, Lorenzini D, Hoang A, Lu W, Soto LMS, Wistuba II, Xu M, Song X, Shepherd PDA, Navone NM, Tidwell RSS, Lozano G, Logothetis C, Zhang J, Long JP, Estecio MR, Tzelepi V, Aparicio AM. Genotype-to-Phenotype Associations in the Aggressive Variant Prostate Cancer Molecular Profile (AVPC-m) Components. Cancers (Basel). 2022 Jun 30; 14(13). PMID: 35805010.
    2. Morrissey RL, Thompson AM, Lozano G. Is loss of p53 a driver of ductal carcinoma in situ progression? Br J Cancer. 2022 Jun 28. PMID: 35764786.
      Citations:    Fields:    
    3. Xiong S, Chachad D, Zhang Y, Gencel-Augusto J, Sirito M, Pant V, Yang P, Sun C, Chau G, Qi Y, Su X, Whitley EM, El-Naggar AK, Lozano G. Differential Gain-of-Function Activity of Three p53 Hotspot Mutants In Vivo. Cancer Res. 2022 05 16; 82(10):1926-1936. PMID: 35320355.
      Citations:    Fields:    Translation:AnimalsCells
    4. Ding J, Li X, Khan S, Zhang C, Gao F, Sen S, Wasylishen AR, Zhao Y, Lozano G, Koul D, Yung WKA. EGFR suppresses p53 function by promoting p53 binding to DNA-PKcs: a non-canonical regulatory axis between EGFR and wild-type p53 in glioblastoma. Neuro Oncol. 2022 Apr 26. PMID: 35474131.
      Citations:    Fields:    
    5. Pant V, Aryal NK, Xiong S, Chau GP, Fowlkes NW, Lozano G. Alterations of the Mdm2 C-Terminus Differentially Impact Its Function In Vivo. Cancer Res. 2022 04 01; 82(7):1313-1320. PMID: 35078816.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Fahrmann JF, Wasylishen AR, Pieterman CRC, Irajizad E, Vykoukal J, Murage E, Wu R, Dennison JB, Krishna H, Peterson CB, Lozano G, Zhao H, Do KA, Halperin DM, Agarwal SK, Blau JE, Del Rivero J, Nilubol N, Walter MF, Welch JM, Weinstein LS, Vriens MR, van Leeuwaarde RS, van Treijen MJC, Valk GD, Perrier ND, Hanash SM. A Blood-based Polyamine Signature Associated With MEN1 Duodenopancreatic Neuroendocrine Tumor Progression. J Clin Endocrinol Metab. 2021 11 19; 106(12):e4969-e4980. PMID: 34318891.
      Citations: 2     Fields:    Translation:Humans
    7. Shah VV, Duncan AD, Jiang S, Stratton SA, Allton KL, Yam C, Jain A, Krause PM, Lu Y, Cai S, Tu Y, Zhou X, Zhang X, Jiang Y, Carroll CL, Kang Z, Liu B, Shen J, Gagea M, Manu SM, Huo L, Gilcrease M, Powell RT, Guo L, Stephan C, Davies PJ, Parker-Thornburg J, Lozano G, Behringer RR, Piwnica-Worms H, Chang JT, Moulder SL, Barton MC. Mammary-specific expression of Trim24 establishes a mouse model of human metaplastic breast cancer. Nat Commun. 2021 09 10; 12(1):5389. PMID: 34508101.
      Citations: 1     Fields:    Translation:HumansAnimals
    8. Zhou X, Beilter A, Xu Z, Gao R, Xiong S, Paulucci-Holthauzen A, Lozano G, de Crombrugghe B, Gorlick R. Wnt/ß-catenin-mediated p53 suppression is indispensable for osteogenesis of mesenchymal progenitor cells. Cell Death Dis. 2021 05 21; 12(6):521. PMID: 34021120.
      Citations: 3     Fields:    Translation:AnimalsCells
    9. Kim MP, Li X, Deng J, Zhang Y, Dai B, Allton KL, Hughes TG, Siangco C, Augustine JJ, Kang Y, McDaniel JM, Xiong S, Koay EJ, McAllister F, Bristow CA, Heffernan TP, Maitra A, Liu B, Barton MC, Wasylishen AR, Fleming JB, Lozano G. Oncogenic KRAS Recruits an Expansive Transcriptional Network through Mutant p53 to Drive Pancreatic Cancer Metastasis. Cancer Discov. 2021 08; 11(8):2094-2111. PMID: 33839689.
      Citations: 15     Fields:    Translation:HumansAnimals
    10. Ueda K, Kumari R, Schwenger E, Wheat JC, Bohorquez O, Narayanagari SR, Taylor SJ, Carvajal LA, Pradhan K, Bartholdy B, Todorova TI, Goto H, Sun D, Chen J, Shan J, Song Y, Montagna C, Xiong S, Lozano G, Pellagatti A, Boultwood J, Verma A, Steidl U. MDMX acts as a pervasive preleukemic-to-acute myeloid leukemia transition mechanism. Cancer Cell. 2021 04 12; 39(4):529-547.e7. PMID: 33667384.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    11. Jeffers JR, Pinto EM, Rehg JE, Clay MR, Wang J, Neale G, Heath RJ, Lozano G, Lalli E, Figueiredo BC, Pappo AS, Rodriguez-Galindo C, Chen W, Pounds S, Ribeiro RC, Zambetti GP. The Common Germline TP53-R337H Mutation Is Hypomorphic and Confers Incomplete Penetrance and Late Tumor Onset in a Mouse Model. Cancer Res. 2021 05 01; 81(9):2442-2456. PMID: 33637564.
      Citations:    Fields:    Translation:AnimalsCells
    12. Moyer SM, Wasylishen AR, Qi Y, Fowlkes N, Su X, Lozano G. p53 drives a transcriptional program that elicits a non-cell-autonomous response and alters cell state in vivo. Proc Natl Acad Sci U S A. 2020 09 22; 117(38):23663-23673. PMID: 32900967.
      Citations: 10     Fields:    Translation:AnimalsCells
    13. Gencel-Augusto J, Lozano G. p53 tetramerization: at the center of the dominant-negative effect of mutant p53. Genes Dev. 2020 09 01; 34(17-18):1128-1146. PMID: 32873579.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    14. Wasylishen AR, Sun C, Moyer SM, Qi Y, Chau GP, Aryal NK, McAllister F, Kim MP, Barton MC, Estrella JS, Su X, Lozano G. Daxx maintains endogenous retroviral silencing and restricts cellular plasticity in vivo. Sci Adv. 2020 08; 6(32):eaba8415. PMID: 32821827.
      Citations: 6     Fields:    Translation:AnimalsCells
    15. Wasylishen AR, Sun C, Chau GP, Qi Y, Su X, Kim MP, Estrella JS, Lozano G. Men1 maintains exocrine pancreas homeostasis in response to inflammation and oncogenic stress. Proc Natl Acad Sci U S A. 2020 03 24; 117(12):6622-6629. PMID: 32156729.
      Citations: 6     Fields:    Translation:Animals
    16. Haupt S, Caramia F, Herschtal A, Soussi T, Lozano G, Chen H, Liang H, Speed TP, Haupt Y. Identification of cancer sex-disparity in the functional integrity of p53 and its X chromosome network. Nat Commun. 2019 11 26; 10(1):5385. PMID: 31772231.
      Citations: 22     Fields:    Translation:HumansCells
    17. Pant V, Xiong S, Wasylishen AR, Larsson CA, Aryal NK, Chau G, Tailor RC, Lozano G. Transient enhancement of p53 activity protects from radiation-induced gastrointestinal toxicity. Proc Natl Acad Sci U S A. 2019 08 27; 116(35):17429-17437. PMID: 31409715.
      Citations: 4     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    18. Lozano G. Restoring p53 in cancer: the promises and the challenges. J Mol Cell Biol. 2019 07 19; 11(7):615-619. PMID: 31283825.
      Citations: 9     Fields:    
    19. Aryal NK, Pant V, Wasylishen AR, Rimel BJ, Baseler L, El-Naggar AK, Mutch DG, Goodfellow PJ, Arur S, Lozano G. Dicer1 Phosphomimetic Promotes Tumor Progression and Dissemination. Cancer Res. 2019 05 15; 79(10):2662-2668. PMID: 30914430.
      Citations: 2     Fields:    Translation:AnimalsCells
    20. Aryal NK, Pant V, Wasylishen AR, Parker-Thornburg J, Baseler L, El-Naggar AK, Liu B, Kalia A, Lozano G, Arur S. Constitutive Dicer1 phosphorylation accelerates metabolism and aging in vivo. Proc Natl Acad Sci U S A. 2019 01 15; 116(3):960-969. PMID: 30593561.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    21. Lozano G. One step at a time. Mol Biol Cell. 2018 11 01; 29(22):2614-2615. PMID: 30376433.
      Citations:    Fields:    Translation:Animals
    22. Aryal NK, Wasylishen AR, Lozano G. CRISPR/Cas9 can mediate high-efficiency off-target mutations in mice in vivo. Cell Death Dis. 2018 10 27; 9(11):1099. PMID: 30368519.
      Citations: 23     Fields:    Translation:AnimalsCells
    23. Zhang Y, Xiong S, Liu B, Pant V, Celii F, Chau G, Elizondo-Fraire AC, Yang P, You MJ, El-Naggar AK, Navin NE, Lozano G. Somatic Trp53 mutations differentially drive breast cancer and evolution of metastases. Nat Commun. 2018 09 27; 9(1):3953. PMID: 30262850.
      Citations: 16     Fields:    Translation:HumansAnimals
    24. Wasylishen AR, Estrella JS, Pant V, Chau GP, Lozano G. Daxx Functions Are p53-Independent In Vivo. Mol Cancer Res. 2018 10; 16(10):1523-1529. PMID: 29903771.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    25. Zhang Y, Zoltan M, Riquelme E, Xu H, Sahin I, Castro-Pando S, Montiel MF, Chang K, Jiang Z, Ling J, Gupta S, Horne W, Pruski M, Wang H, Sun SC, Lozano G, Chiao P, Maitra A, Leach SD, Kolls JK, Vilar E, Wang TC, Bailey JM, McAllister F. Immune Cell Production of Interleukin 17 Induces Stem Cell Features of Pancreatic Intraepithelial Neoplasia Cells. Gastroenterology. 2018 07; 155(1):210-223.e3. PMID: 29604293.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    26. Dibra D, Xia X, Gagea M, Lozano G, Li S. A spontaneous model of spondyloarthropathies that develops bone loss and pathological bone formation: A process regulated by IL27RA-/- and mutant-p53. PLoS One. 2018; 13(3):e0193485. PMID: 29494633.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    27. Larsson CA, Moyer SM, Liu B, Michel KA, Pant V, Yang P, Wong J, El-Naggar AK, Krahe R, Lozano G. Synergistic and additive effect of retinoic acid in circumventing resistance to p53 restoration. Proc Natl Acad Sci U S A. 2018 02 27; 115(9):2198-2203. PMID: 29440484.
      Citations: 4     Fields:    Translation:AnimalsCells
    28. Ortiz GJ, Lozano G. SNPing away at mutant p53 activities. Genes Dev. 2018 02 01; 32(3-4):195-196. PMID: 29491132.
      Citations: 2     Fields:    Translation:HumansCells
    29. Kim MP, Lozano G. Mutant p53 partners in crime. Cell Death Differ. 2018 01; 25(1):161-168. PMID: 29099488.
      Citations: 119     Fields:    Translation:Humans
    30. Aryal NK, Wasylishen AR, Pant V, Riley-Croce M, Lozano G. Loss of digestive organ expansion factor (Diexf) reveals an essential role during murine embryonic development that is independent of p53. Oncotarget. 2017 Nov 28; 8(61):103996-104006. PMID: 29262616.
      Citations: 4     Fields:    
    31. Liu B, Mitani Y, Rao X, Zafereo M, Zhang J, Zhang J, Futreal PA, Lozano G, El-Naggar AK. Spatio-Temporal Genomic Heterogeneity, Phylogeny, and Metastatic Evolution in Salivary Adenoid Cystic Carcinoma. J Natl Cancer Inst. 2017 10 01; 109(10). PMID: 29117356.
      Citations: 11     Fields:    Translation:Humans
    32. Ortiz GJ, Li Y, Post SM, Pant V, Xiong S, Larsson CA, El-Naggar AK, Johnson DG, Lozano G. Contrasting effects of an Mdm2 functional polymorphism on tumor phenotypes. Oncogene. 2018 01 18; 37(3):332-340. PMID: 28925402.
      Citations: 6     Fields:    Translation:AnimalsCells
    33. Pourebrahim R, Zhang Y, Liu B, Gao R, Xiong S, Lin PP, McArthur MJ, Ostrowski MC, Lozano G. Integrative genome analysis of somatic p53 mutant osteosarcomas identifies Ets2-dependent regulation of small nucleolar RNAs by mutant p53 protein. Genes Dev. 2017 09 15; 31(18):1847-1857. PMID: 29021240.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    34. Pant V, Larsson CA, Aryal N, Xiong S, You MJ, Quintas-Cardama A, Lozano G. Tumorigenesis promotes Mdm4-S overexpression. Oncotarget. 2017 Apr 18; 8(16):25837-25847. PMID: 28460439.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    35. Jackson JG, Lozano G. TNBC invasion: downstream of STAT3. Oncotarget. 2017 03 28; 8(13):20517-20518. PMID: 28199968.
      Citations: 3     Fields:    Translation:HumansCells
    36. Tonnessen-Murray CA, Lozano G, Jackson JG. The Regulation of Cellular Functions by the p53 Protein: Cellular Senescence. Cold Spring Harb Perspect Med. 2017 Feb 01; 7(2). PMID: 27881444.
      Citations: 17     Fields:    Translation:HumansCells
    37. Moyer SM, Larsson CA, Lozano G. Mdm proteins: critical regulators of embry ogenesis and homeostasis. J Mol Cell Biol. 2017 Jan 15. PMID: 28093454.
      Citations: 19     Fields:    
    38. Xiong S, Pant V, Zhang Y, Aryal NK, You MJ, Kusewitt D, Lozano G. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. J Pathol. 2017 03; 241(4):501-510. PMID: 27925213.
      Citations: 17     Fields:    Translation:HumansAnimals
    39. Lozano G. The Enigma of p53. Cold Spring Harb Symp Quant Biol. 2016; 81:37-40. PMID: 27932563.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    40. Zhang Y, Lozano G. p53: Multiple Facets of a Rubik's Cube. Annu Rev Cancer Biol. 2017 Mar; 1:185-201. PMID: 30775651.
      Citations: 8     
    41. Wasylishen AR, Lozano G. Attenuating the p53 Pathway in Human Cancers: Many Means to the Same End. Cold Spring Harb Perspect Med. 2016 08 01; 6(8). PMID: 27329033.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    42. Pant V, Xiong S, Chau G, Tsai K, Shetty G, Lozano G. Distinct downstream targets manifest p53-dependent pathologies in mice. Oncogene. 2016 11 03; 35(44):5713-5721. PMID: 27065327.
      Citations: 11     Fields:    Translation:AnimalsCells
    43. Dibra D, Mitra A, Newman M, Xia X, Cutrera JJ, Gagea M, Kleinerman ES, Lozano G, Li S. Lack of Immunomodulatory Interleukin-27 Enhances Oncogenic Properties of Mutant p53 In Vivo. Clin Cancer Res. 2016 08 01; 22(15):3876-83. PMID: 26979394.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    44. Xie X, Lozano G, Siddik ZH. Heterozygous p53(V172F) mutation in cisplatin-resistant human tumor cells promotes MDM4 recruitment and decreases stability and transactivity of p53. Oncogene. 2016 09 08; 35(36):4798-806. PMID: 26876197.
      Citations: 9     Fields:    Translation:HumansCells
    45. Dibra D, Xia X, Mitra A, Cutrera JJ, Lozano G, Li S. Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice. Hepatology. 2016 Mar; 63(3):1000-12. PMID: 26637970.
      Citations: 13     Fields:    Translation:AnimalsCells
    46. Wienken M, Dickmanns A, Nemajerova A, Kramer D, Najafova Z, Weiss M, Karpiuk O, Kassem M, Zhang Y, Lozano G, Johnsen SA, Moll UM, Zhang X, Dobbelstein M. MDM2 Associates with Polycomb Repressor Complex 2 and Enhances Stemness-Promoting Chromatin Modifications Independent of p53. Mol Cell. 2016 Jan 07; 61(1):68-83. PMID: 26748827.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    47. Mitani Y, Liu B, Rao PH, Borra VJ, Zafereo M, Weber RS, Kies M, Lozano G, Futreal PA, Caulin C, El-Naggar AK. Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clin Cancer Res. 2016 Feb 01; 22(3):725-33. PMID: 26631609.
      Citations: 61     Fields:    Translation:HumansCells
    48. Kim MP, Zhang Y, Lozano G. Mutant p53: Multiple Mechanisms Define Biologic Activity in Cancer. Front Oncol. 2015; 5:249. PMID: 26618142.
      Citations: 45     
    49. Tashakori M, Zhang Y, Xiong S, You MJ, Lozano G. p53 Activity Dominates That of p73 upon Mdm4 Loss in Development and Tumorigenesis. Mol Cancer Res. 2016 Jan; 14(1):56-65. PMID: 26527653.
      Citations: 6     Fields:    Translation:Animals
    50. Goh AM, Xue Y, Leushacke M, Li L, Wong JS, Chiam PC, Rahmat SA, Mann MB, Mann KM, Barker N, Lozano G, Terzian T, Lane DP. Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice. Oncotarget. 2015 Jul 20; 6(20):17968-80. PMID: 26255629.
      Citations: 7     Fields:    Translation:Animals
    51. Riley MF, You MJ, Multani AS, Lozano G. Mdm2 overexpression and p73 loss exacerbate genomic instability and dampen apoptosis, resulting in B-cell lymphoma. Oncogene. 2016 Jan 21; 35(3):358-65. PMID: 25915849.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    52. Jiang S, Minter LC, Stratton SA, Yang P, Abbas HA, Akdemir ZC, Pant V, Post S, Gagea M, Lee RG, Lozano G, Barton MC. TRIM24 suppresses development of spontaneous hepatic lipid accumulation and hepatocellular carcinoma in mice. J Hepatol. 2015 Feb; 62(2):371-9. PMID: 25281858.
      Citations: 27     Fields:    Translation:HumansAnimals
    53. Pant V, Lozano G. Limiting the power of p53 through the ubiquitin proteasome pathway. Genes Dev. 2014 Aug 15; 28(16):1739-51. PMID: 25128494.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    54. Quintás-Cardama A, Post SM, Solis LM, Xiong S, Yang P, Chen N, Wistuba II, Killary AM, Lozano G. Loss of the novel tumour suppressor and polarity gene Trim62 (Dear1) synergizes with oncogenic Ras in invasive lung cancer. J Pathol. 2014 Sep; 234(1):108-19. PMID: 24890125.
      Citations: 12     Fields:    Translation:HumansAnimals
    55. Xiong S, Tu H, Kollareddy M, Pant V, Li Q, Zhang Y, Jackson JG, Suh YA, Elizondo-Fraire AC, Yang P, Chau G, Tashakori M, Wasylishen AR, Ju Z, Solomon H, Rotter V, Liu B, El-Naggar AK, Donehower LA, Martinez LA, Lozano G. Pla2g16 phospholipase mediates gain-of-function activities of mutant p53. Proc Natl Acad Sci U S A. 2014 Jul 29; 111(30):11145-50. PMID: 25024203.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    56. Zhang Y, Xiong S, Li Q, Hu S, Tashakori M, Van Pelt C, You MJ, Pageon L, Lozano G. Tissue-specific and age-dependent effects of global Mdm2 loss. J Pathol. 2014 Aug; 233(4):380-91. PMID: 24789767.
      Citations: 23     Fields:    Translation:Animals
    57. Yokoyama M, Okada S, Nakagomi A, Moriya J, Shimizu I, Nojima A, Yoshida Y, Ichimiya H, Kamimura N, Kobayashi Y, Ohta S, Fruttiger M, Lozano G, Minamino T. Inhibition of endothelial p53 improves metabolic abnormalities related to dietary obesity. Cell Rep. 2014 Jun 12; 7(5):1691-1703. PMID: 24857662.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    58. Zou Q, Jin J, Hu H, Li HS, Romano S, Xiao Y, Nakaya M, Zhou X, Cheng X, Yang P, Lozano G, Zhu C, Watowich SS, Ullrich SE, Sun SC. USP15 stabilizes MDM2 to mediate cancer-cell survival and inhibit antitumor T cell responses. Nat Immunol. 2014 Jun; 15(6):562-70. PMID: 24777531.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    59. Pant V, Lozano G. Dissecting the p53-Mdm2 feedback loop in vivo: uncoupling the role in p53 stability and activity. Oncotarget. 2014 Mar 15; 5(5):1149-56. PMID: 24658419.
      Citations: 15     Fields:    Translation:AnimalsCells
    60. Ma J, Xiong M, You M, Lozano G, Amos CI. Genome-wide association tests of inversions with application to psoriasis. Hum Genet. 2014 Aug; 133(8):967-74. PMID: 24623382.
      Citations: 5     Fields:    Translation:Humans
    61. Eischen CM, Lozano G. The Mdm network and its regulation of p53 activities: a rheostat of cancer risk. Hum Mutat. 2014 Jun; 35(6):728-37. PMID: 24488925.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    62. Li Q, Zhang Y, El-Naggar AK, Xiong S, Yang P, Jackson JG, Chau G, Lozano G. Therapeutic efficacy of p53 restoration in Mdm2-overexpressing tumors. Mol Cancer Res. 2014 Jun; 12(6):901-11. PMID: 24598047.
      Citations: 17     Fields:    Translation:AnimalsCells
    63. Tordella L, Koch S, Salter V, Pagotto A, Doondeea JB, Feller SM, Ratnayaka I, Zhong S, Goldin RD, Lozano G, McKeon FD, Tavassoli M, Fritzsche F, Huber GF, Rössle M, Moch H, Lu X. ASPP2 suppresses squamous cell carcinoma via RelA/p65-mediated repression of p63. Proc Natl Acad Sci U S A. 2013 Oct 29; 110(44):17969-74. PMID: 24127607.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    64. Pant V, Xiong S, Jackson JG, Post SM, Abbas HA, Quintás-Cardama A, Hamir AN, Lozano G. The p53-Mdm2 feedback loop protects against DNA damage by inhibiting p53 activity but is dispensable for p53 stability, development, and longevity. Genes Dev. 2013 Sep 01; 27(17):1857-67. PMID: 23973961.
      Citations: 45     Fields:    Translation:AnimalsCells
    65. Chen N, Balasenthil S, Reuther J, Frayna A, Wang Y, Chandler DS, Abruzzo LV, Rashid A, Rodriguez J, Lozano G, Cao Y, Lokken E, Chen J, Frazier ML, Sahin AA, Wistuba II, Sen S, Lott ST, Killary AM. DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-ß-driven epithelial-mesenchymal transition. Cancer Discov. 2013 Oct; 3(10):1172-89. PMID: 23838884.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    66. Cooks T, Pateras IS, Tarcic O, Solomon H, Schetter AJ, Wilder S, Lozano G, Pikarsky E, Forshew T, Rosenfeld N, Rozenfeld N, Harpaz N, Itzkowitz S, Harris CC, Rotter V, Gorgoulis VG, Oren M. Mutant p53 prolongs NF-?B activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell. 2013 May 13; 23(5):634-46. PMID: 23680148.
      Citations: 214     Fields:    Translation:HumansAnimals
    67. Haupt S, Mitchell C, Corneille V, Shortt J, Fox S, Pandolfi PP, Castillo-Martin M, Bonal DM, Cordon-Cardo C, Lozano G, Haupt Y. Loss of PML cooperates with mutant p53 to drive more aggressive cancers in a gender-dependent manner. Cell Cycle. 2013 Jun 01; 12(11):1722-31. PMID: 23656786.
      Citations: 15     Fields:    Translation:HumansAnimals
    68. Chen YC, Chan JY, Chiu YL, Liu ST, Lozano G, Wang SL, Ho CL, Huang SM. Grail as a molecular determinant for the functions of the tumor suppressor p53 in tumorigenesis. Cell Death Differ. 2013 May; 20(5):732-43. PMID: 23370271.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    69. Jackson JG, Lozano G. The mutant p53 mouse as a pre-clinical model. Oncogene. 2013 Sep 12; 32(37):4325-30. PMID: 23318424.
      Citations: 32     Fields:    Translation:HumansAnimals
    70. Li Q, Lozano G. Molecular pathways: targeting Mdm2 and Mdm4 in cancer therapy. Clin Cancer Res. 2013 Jan 01; 19(1):34-41. PMID: 23262034.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    71. Pant V, Quintás-Cardama A, Lozano G. The p53 pathway in hematopoiesis: lessons from mouse models, implications for humans. Blood. 2012 Dec 20; 120(26):5118-27. PMID: 23018641.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    72. Flores ER, Lozano G. The p53 family grows old. Genes Dev. 2012 Sep 15; 26(18):1997-2000. PMID: 22987633.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    73. Cantley LC, Dalton WS, DuBois RN, Finn OJ, Futreal PA, Golub TR, Hait WN, Lozano G, Maris JM, Nelson WG, Sawyers CL, Schreiber SL, Spitz MR, Steeg PS. AACR Cancer Progress Report 2012. Clin Cancer Res. 2012 Nov 01; 18(21 Suppl):S1-100. PMID: 22977188.
      Citations: 10     Fields:    Translation:Humans
    74. Jackson JG, Lozano G. Che-ating death: CHE1/AATF protects from p53-mediated apoptosis. EMBO J. 2012 Oct 17; 31(20):3951-3. PMID: 22960635.
      Citations: 2     Fields:    Translation:HumansAnimals
    75. Jackson JG, Pant V, Li Q, Chang LL, Quintás-Cardama A, Garza D, Tavana O, Yang P, Manshouri T, Li Y, El-Naggar AK, Lozano G. p53-mediated senescence impairs the apoptotic response to chemotherapy and clinical outcome in breast cancer. Cancer Cell. 2012 Jun 12; 21(6):793-806. PMID: 22698404.
      Citations: 142     Fields:    Translation:HumansAnimalsCells
    76. Hallenborg P, Feddersen S, Francoz S, Murano I, Sundekilde U, Petersen RK, Akimov V, Olson MV, Lozano G, Cinti S, Gjertsen BT, Madsen L, Marine JC, Blagoev B, Kristiansen K. Mdm2 controls CREB-dependent transactivation and initiation of adipocyte differentiation. Cell Death Differ. 2012 Aug; 19(8):1381-9. PMID: 22388350.
      Citations: 19     Fields:    Translation:AnimalsCells
    77. Riley MF, Lozano G. The Many Faces of MDM2 Binding Partners. Genes Cancer. 2012 Mar; 3(3-4):226-39. PMID: 23150756.
      Citations: 38     
    78. Xiong S, Parker-Thornburg J, Lozano G. Developing genetically engineered mouse models to study tumor suppression. Curr Protoc Mouse Biol. 2012 Mar 01; 2(1):9-24. PMID: 22582146.
      Citations:    Fields:    
    79. Blandino G, Deppert W, Hainaut P, Levine A, Lozano G, Olivier M, Rotter V, Wiman K, Oren M. Mutant p53 protein, master regulator of human malignancies: a report on the Fifth Mutant p53 Workshop. Cell Death Differ. 2012 Jan; 19(1):180-3. PMID: 22095277.
      Citations: 21     Fields:    Translation:HumansAnimals
    80. Lin S, Yu L, Yang J, Liu Z, Karia B, Bishop AJR, Jackson J, Lozano G, Copland JA, Mu X, Sun B, Sun LZ. Mutant p53 disrupts role of ShcA protein in balancing Smad protein-dependent and -independent signaling activity of transforming growth factor-ß (TGF-ß). J Biol Chem. 2011 Dec 23; 286(51):44023-44034. PMID: 22039050.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    81. Suh YA, Post SM, Elizondo-Fraire AC, Maccio DR, Jackson JG, El-Naggar AK, Van Pelt C, Terzian T, Lozano G. Multiple stress signals activate mutant p53 in vivo. Cancer Res. 2011 Dec 01; 71(23):7168-75. PMID: 21983037.
      Citations: 61     Fields:    Translation:AnimalsCells
    82. Abbas HA, Pant V, Lozano G. The ups and downs of p53 regulation in hematopoietic stem cells. Cell Cycle. 2011 Oct 01; 10(19):3257-62. PMID: 21957490.
      Citations: 17     Fields:    Translation:AnimalsCells
    83. McEvoy J, Flores-Otero J, Zhang J, Nemeth K, Brennan R, Bradley C, Krafcik F, Rodriguez-Galindo C, Wilson M, Xiong S, Lozano G, Sage J, Fu L, Louhibi L, Trimarchi J, Pani A, Smeyne R, Johnson D, Dyer MA. Coexpression of normally incompatible developmental pathways in retinoblastoma genesis. Cancer Cell. 2011 Aug 16; 20(2):260-75. PMID: 21840489.
      Citations: 74     Fields:    Translation:HumansAnimals
    84. Girardini JE, Napoli M, Piazza S, Rustighi A, Marotta C, Radaelli E, Capaci V, Jordan L, Quinlan P, Thompson A, Mano M, Rosato A, Crook T, Scanziani E, Means AR, Lozano G, Schneider C, Del Sal G. A Pin1/mutant p53 axis promotes aggressiveness in breast cancer. Cancer Cell. 2011 Jul 12; 20(1):79-91. PMID: 21741598.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    85. Pant V, Xiong S, Iwakuma T, Quintás-Cardama A, Lozano G. Heterodimerization of Mdm2 and Mdm4 is critical for regulating p53 activity during embryogenesis but dispensable for p53 and Mdm2 stability. Proc Natl Acad Sci U S A. 2011 Jul 19; 108(29):11995-2000. PMID: 21730132.
      Citations: 88     Fields:    Translation:AnimalsCells
    86. Terzian T, Dumble M, Arbab F, Thaller C, Donehower LA, Lozano G, Justice MJ, Roop DR, Box NF. Rpl27a mutation in the sooty foot ataxia mouse phenocopies high p53 mouse models. J Pathol. 2011 Aug; 224(4):540-52. PMID: 21674502.
      Citations: 18     Fields:    Translation:AnimalsCells
    87. Williams MD, Zhang L, Elliott DD, Perrier ND, Lozano G, Clayman GL, El-Naggar AK. Differential gene expression profiling of aggressive and nonaggressive follicular carcinomas. Hum Pathol. 2011 Sep; 42(9):1213-20. PMID: 21420716.
      Citations: 11     Fields:    Translation:Humans
    88. Wang Y, Suh YA, Fuller MY, Jackson JG, Xiong S, Terzian T, Quintás-Cardama A, Bankson JA, El-Naggar AK, Lozano G. Restoring expression of wild-type p53 suppresses tumor growth but does not cause tumor regression in mice with a p53 missense mutation. J Clin Invest. 2011 Mar; 121(3):893-904. PMID: 21285512.
      Citations: 75     Fields:    Translation:AnimalsCells
    89. Wu CC, Krahe R, Lozano G, Zhang B, Wilson CD, Jo EJ, Amos CI, Shete S, Strong LC. Joint effects of germ-line TP53 mutation, MDM2 SNP309, and gender on cancer risk in family studies of Li-Fraumeni syndrome. Hum Genet. 2011 Jun; 129(6):663-73. PMID: 21305319.
      Citations: 13     Fields:    Translation:Humans
    90. Zhao R, Yeung SC, Chen J, Iwakuma T, Su CH, Chen B, Qu C, Zhang F, Chen YT, Lin YL, Lee DF, Jin F, Zhu R, Shaikenov T, Sarbassov D, Sahin A, Wang H, Wang H, Lai CC, Tsai FJ, Lozano G, Lee MH. Subunit 6 of the COP9 signalosome promotes tumorigenesis in mice through stabilization of MDM2 and is upregulated in human cancers. J Clin Invest. 2011 Mar; 121(3):851-65. PMID: 21317535.
      Citations: 62     Fields:    Translation:HumansAnimalsCells
    91. Terzian T, Torchia EC, Dai D, Robinson SE, Murao K, Stiegmann RA, Gonzalez V, Boyle GM, Powell MB, Pollock PM, Lozano G, Robinson WA, Roop DR, Box NF. p53 prevents progression of nevi to melanoma predominantly through cell cycle regulation. Pigment Cell Melanoma Res. 2010 Dec; 23(6):781-94. PMID: 20849464.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    92. Abbas HA, Maccio DR, Coskun S, Jackson JG, Hazen AL, Sills TM, You MJ, Hirschi KK, Lozano G. Mdm2 is required for survival of hematopoietic stem cells/progenitors via dampening of ROS-induced p53 activity. Cell Stem Cell. 2010 Nov 05; 7(5):606-17. PMID: 21040902.
      Citations: 76     Fields:    Translation:AnimalsCells
    93. Jackson JG, Post SM, Lozano G. Regulation of tissue- and stimulus-specific cell fate decisions by p53 in vivo. J Pathol. 2011 Jan; 223(2):127-36. PMID: 20957626.
      Citations: 34     Fields:    Translation:HumansAnimalsPHPublic Health
    94. Terzian T, Lozano G. Building p53. Genes Dev. 2010 Oct 15; 24(20):2229-32. PMID: 20952532.
      Citations:    Fields:    Translation:HumansCells
    95. Addadi Y, Moskovits N, Granot D, Lozano G, Carmi Y, Apte RN, Neeman M, Oren M. p53 status in stromal fibroblasts modulates tumor growth in an SDF1-dependent manner. Cancer Res. 2010 Dec 01; 70(23):9650-8. PMID: 20952507.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    96. Lin PP, Wang Y, Lozano G. Mesenchymal Stem Cells and the Origin of Ewing's Sarcoma. Sarcoma. 2011; 2011. PMID: 20953407.
      Citations: 24     
    97. Post SM, Lozano G. You can win by losing: p53 mutations in rhabdomyosarcomas. J Pathol. 2010 Oct; 222(2):124-8. PMID: 20821751.
      Citations: 2     Fields:    Translation:HumansAnimals
    98. Post SM, Quintás-Cardama A, Pant V, Iwakuma T, Hamir A, Jackson JG, Maccio DR, Bond GL, Johnson DG, Levine AJ, Lozano G. A high-frequency regulatory polymorphism in the p53 pathway accelerates tumor development. Cancer Cell. 2010 Sep 14; 18(3):220-30. PMID: 20832750.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    99. Tian L, Peng G, Parant JM, Leventaki V, Drakos E, Zhang Q, Parker-Thornburg J, Shackleford TJ, Dai H, Lin SY, Lozano G, Rassidakis GZ, Claret FX. Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010 Nov 18; 29(46):6125-37. PMID: 20802511.
      Citations: 33     Fields:    Translation:AnimalsCells
    100. Xiong S, Pant V, Suh YA, Van Pelt CS, Wang Y, Valentin-Vega YA, Post SM, Lozano G. Spontaneous tumorigenesis in mice overexpressing the p53-negative regulator Mdm4. Cancer Res. 2010 Sep 15; 70(18):7148-54. PMID: 20736370.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    101. Fang S, Krahe R, Lozano G, Han Y, Chen W, Post SM, Zhang B, Wilson CD, Bachinski LL, Strong LC, Amos CI. Effects of MDM2, MDM4 and TP53 codon 72 polymorphisms on cancer risk in a cohort study of carriers of TP53 germline mutations. PLoS One. 2010 May 26; 5(5):e10813. PMID: 20520810.
      Citations: 18     Fields:    Translation:Humans
    102. Nurieva RI, Zheng S, Jin W, Chung Y, Zhang Y, Martinez GJ, Reynolds JM, Wang SL, Lin X, Sun SC, Lozano G, Dong C. The E3 ubiquitin ligase GRAIL regulates T cell tolerance and regulatory T cell function by mediating T cell receptor-CD3 degradation. Immunity. 2010 May 28; 32(5):670-80. PMID: 20493730.
      Citations: 76     Fields:    Translation:AnimalsCells
    103. Odvody J, Vincent T, Arrate MP, Grieb B, Wang S, Garriga J, Lozano G, Iwakuma T, Haines DS, Eischen CM. A deficiency in Mdm2 binding protein inhibits Myc-induced B-cell proliferation and lymphomagenesis. Oncogene. 2010 Jun 03; 29(22):3287-96. PMID: 20305689.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    104. Marine JC, Lozano G. Mdm2-mediated ubiquitylation: p53 and beyond. Cell Death Differ. 2010 Jan; 17(1):93-102. PMID: 19498444.
      Citations: 151     Fields:    Translation:HumansCells
    105. Lozano G. Mouse models of p53 functions. Cold Spring Harb Perspect Biol. 2010 Apr; 2(4):a001115. PMID: 20452944.
      Citations: 51     Fields:    Translation:Animals
    106. Post SM, Quintás-Cardama A, Terzian T, Smith C, Eischen CM, Lozano G. p53-dependent senescence delays Emu-myc-induced B-cell lymphomagenesis. Oncogene. 2010 Mar 04; 29(9):1260-9. PMID: 19935700.
      Citations: 36     Fields:    Translation:AnimalsCells
    107. Martinez LA, Goluszko E, Chen HZ, Leone G, Post S, Lozano G, Chen Z, Chauchereau A. E2F3 is a mediator of DNA damage-induced apoptosis. Mol Cell Biol. 2010 Jan; 30(2):524-36. PMID: 19917728.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    108. Donehower LA, Lozano G. 20 years studying p53 functions in genetically engineered mice. Nat Rev Cancer. 2009 11; 9(11):831-41. PMID: 19776746.
      Citations: 109     Fields:    Translation:HumansAnimals
    109. Lin PP, Pandey MK, Jin F, Raymond AK, Akiyama H, Lozano G. Targeted mutation of p53 and Rb in mesenchymal cells of the limb bud produces sarcomas in mice. Carcinogenesis. 2009 Oct; 30(10):1789-95. PMID: 19635748.
      Citations: 56     Fields:    Translation:AnimalsCells
    110. Gibbons DL, Lin W, Creighton CJ, Zheng S, Berel D, Yang Y, Raso MG, Liu DD, Wistuba II, Lozano G, Kurie JM. Expression signatures of metastatic capacity in a genetic mouse model of lung adenocarcinoma. PLoS One. 2009; 4(4):e5401. PMID: 19404390.
      Citations: 42     Fields:    Translation:Animals
    111. Valentin-Vega YA, Box N, Terzian T, Lozano G. Mdm4 loss in the intestinal epithelium leads to compartmentalized cell death but no tissue abnormalities. Differentiation. 2009 Jun; 77(5):442-9. PMID: 19371999.
      Citations: 21     Fields:    Translation:Animals
    112. Eischen CM, Lozano G. p53 and MDM2: antagonists or partners in crime? Cancer Cell. 2009 Mar 03; 15(3):161-2. PMID: 19249672.
      Citations: 19     Fields:    Translation:HumansAnimals
    113. Molchadsky A, Shats I, Goldfinger N, Pevsner-Fischer M, Olson M, Rinon A, Tzahor E, Lozano G, Zipori D, Sarig R, Rotter V. p53 plays a role in mesenchymal differentiation programs, in a cell fate dependent manner. PLoS One. 2008; 3(11):e3707. PMID: 19002260.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    114. Lin PP, Pandey MK, Jin F, Xiong S, Deavers M, Parant JM, Lozano G. EWS-FLI1 induces developmental abnormalities and accelerates sarcoma formation in a transgenic mouse model. Cancer Res. 2008 Nov 01; 68(21):8968-75. PMID: 18974141.
      Citations: 50     Fields:    Translation:AnimalsCells
    115. Valentin-Vega YA, Okano H, Lozano G. The intestinal epithelium compensates for p53-mediated cell death and guarantees organismal survival. Cell Death Differ. 2008 Nov; 15(11):1772-81. PMID: 18636077.
      Citations: 33     Fields:    Translation:AnimalsCells
    116. Barboza JA, Iwakuma T, Terzian T, El-Naggar AK, Lozano G. Mdm2 and Mdm4 loss regulates distinct p53 activities. Mol Cancer Res. 2008 Jun; 6(6):947-54. PMID: 18567799.
      Citations: 46     Fields:    Translation:AnimalsCells
    117. Terzian T, Suh YA, Iwakuma T, Post SM, Neumann M, Lang GA, Van Pelt CS, Lozano G. The inherent instability of mutant p53 is alleviated by Mdm2 or p16INK4a loss. Genes Dev. 2008 May 15; 22(10):1337-44. PMID: 18483220.
      Citations: 190     Fields:    Translation:AnimalsCells
    118. Atwal GS, Rabadán R, Lozano G, Strong LC, Ruijs MW, Schmidt MK, van't Veer LJ, Nevanlinna H, Tommiska J, Aittomäki K, Bougeard G, Frebourg T, Levine AJ, Bond GL. An information-theoretic analysis of genetics, gender and age in cancer patients. PLoS One. 2008 Apr 09; 3(4):e1951. PMID: 18398474.
      Citations: 11     Fields:    Translation:HumansCells
    119. Liu G, Terzian T, Xiong S, Van Pelt CS, Audiffred A, Box NF, Lozano G. The p53-Mdm2 network in progenitor cell expansion during mouse postnatal development. J Pathol. 2007 Dec; 213(4):360-8. PMID: 17893884.
      Citations: 36     Fields:    Translation:AnimalsCells
    120. Iwakuma T, Tochigi Y, Van Pelt CS, Caldwell LC, Terzian T, Parant JM, Chau GP, Koch JG, Eischen CM, Lozano G. Mtbp haploinsufficiency in mice increases tumor metastasis. Oncogene. 2008 Mar 20; 27(13):1813-20. PMID: 17906694.
      Citations: 18     Fields:    Translation:Animals
    121. Valentin-Vega YA, Barboza JA, Chau GP, El-Naggar AK, Lozano G. High levels of the p53 inhibitor MDM4 in head and neck squamous carcinomas. Hum Pathol. 2007 Oct; 38(10):1553-62. PMID: 17651783.
      Citations: 38     Fields:    Translation:HumansCells
    122. Caulin C, Nguyen T, Lang GA, Goepfert TM, Brinkley BR, Cai WW, Lozano G, Roop DR. An inducible mouse model for skin cancer reveals distinct roles for gain- and loss-of-function p53 mutations. J Clin Invest. 2007 Jul; 117(7):1893-901. PMID: 17607363.
      Citations: 63     Fields:    Translation:AnimalsCells
    123. Koch JG, Gu X, Han Y, El-Naggar AK, Olson MV, Medina D, Jerry DJ, Blackburn AC, Peltz G, Amos CI, Lozano G. Mammary tumor modifiers in BALB/cJ mice heterozygous for p53. Mamm Genome. 2007 May; 18(5):300-9. PMID: 17557176.
      Citations: 25     Fields:    Translation:Animals
    124. Xiong S, Van Pelt CS, Elizondo-Fraire AC, Fernandez-Garcia B, Lozano G. Loss of Mdm4 results in p53-dependent dilated cardiomyopathy. Circulation. 2007 Jun 12; 115(23):2925-30. PMID: 17533180.
      Citations: 40     Fields:    Translation:AnimalsCells
    125. Terzian T, Wang Y, Van Pelt CS, Box NF, Travis EL, Lozano G. Haploinsufficiency of Mdm2 and Mdm4 in tumorigenesis and development. Mol Cell Biol. 2007 Aug; 27(15):5479-85. PMID: 17526734.
      Citations: 73     Fields:    Translation:Animals
    126. Zheng S, El-Naggar AK, Kim ES, Kurie JM, Lozano G. A genetic mouse model for metastatic lung cancer with gender differences in survival. Oncogene. 2007 Oct 18; 26(48):6896-904. PMID: 17486075.
      Citations: 58     Fields:    Translation:Animals
    127. Iwakuma T, Lozano G. Crippling p53 activities via knock-in mutations in mouse models. Oncogene. 2007 Apr 02; 26(15):2177-84. PMID: 17401426.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    128. Cosme-Blanco W, Shen MF, Lazar AJ, Pathak S, Lozano G, Multani AS, Chang S. Telomere dysfunction suppresses spontaneous tumorigenesis in vivo by initiating p53-dependent cellular senescence. EMBO Rep. 2007 May; 8(5):497-503. PMID: 17396137.
      Citations: 83     Fields:    Translation:AnimalsCells
    129. Lozano G, Behringer RR. New mouse models of cancer: single-cell knockouts. Proc Natl Acad Sci U S A. 2007 Mar 13; 104(11):4245-6. PMID: 17360508.
      Citations: 5     Fields:    Translation:HumansAnimals
    130. Bu P, Evrard YA, Lozano G, Dent SY. Loss of Gcn5 acetyltransferase activity leads to neural tube closure defects and exencephaly in mouse embryos. Mol Cell Biol. 2007 May; 27(9):3405-16. PMID: 17325035.
      Citations: 73     Fields:    Translation:AnimalsCells
    131. Lozano G. The oncogenic roles of p53 mutants in mouse models. Curr Opin Genet Dev. 2007 Feb; 17(1):66-70. PMID: 17208429.
      Citations: 40     Fields:    Translation:Animals
    132. Barboza JA, Liu G, Ju Z, El-Naggar AK, Lozano G. p21 delays tumor onset by preservation of chromosomal stability. Proc Natl Acad Sci U S A. 2006 Dec 26; 103(52):19842-7. PMID: 17170138.
      Citations: 54     Fields:    Translation:AnimalsCells
    133. Han X, Garcia-Manero G, McDonnell TJ, Lozano G, Medeiros LJ, Xiao L, Rosner G, Nguyen M, Fernandez M, Valentin-Vega YA, Barboza J, Jones DM, Rassidakis GZ, Kantarjian HM, Bueso-Ramos CE. HDM4 (HDMX) is widely expressed in adult pre-B acute lymphoblastic leukemia and is a potential therapeutic target. Mod Pathol. 2007 Jan; 20(1):54-62. PMID: 17143258.
      Citations: 25     Fields:    Translation:HumansCells
    134. Maetens M, Doumont G, Clercq SD, Francoz S, Froment P, Bellefroid E, Klingmuller U, Lozano G, Marine JC. Distinct roles of Mdm2 and Mdm4 in red cell production. Blood. 2007 Mar 15; 109(6):2630-3. PMID: 17105817.
      Citations: 46     Fields:    Translation:AnimalsCells
    135. Chandler DS, Singh RK, Caldwell LC, Bitler JL, Lozano G. Genotoxic stress induces coordinately regulated alternative splicing of the p53 modulators MDM2 and MDM4. Cancer Res. 2006 Oct 01; 66(19):9502-8. PMID: 17018606.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    136. Ayanga B, Price R, Gu X, Lozano G, Evans SC. Genetic mapping of a putative tumor suppressor locus that influences tumorigenesis and metastasis in mice. Genes Chromosomes Cancer. 2006 Jul; 45(7):668-75. PMID: 16586494.
      Citations:    Fields:    Translation:Animals
    137. Marine JC, Francoz S, Maetens M, Wahl G, Toledo F, Lozano G. Keeping p53 in check: essential and synergistic functions of Mdm2 and Mdm4. Cell Death Differ. 2006 Jun; 13(6):927-34. PMID: 16543935.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    138. Lee MH, Lozano G. Regulation of the p53-MDM2 pathway by 14-3-3 sigma and other proteins. Semin Cancer Biol. 2006 Jun; 16(3):225-34. PMID: 16697215.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    139. Xiong S, Van Pelt CS, Elizondo-Fraire AC, Liu G, Lozano G. Synergistic roles of Mdm2 and Mdm4 for p53 inhibition in central nervous system development. Proc Natl Acad Sci U S A. 2006 Feb 28; 103(9):3226-31. PMID: 16492743.
      Citations: 80     Fields:    Translation:Animals
    140. Grier JD, Xiong S, Elizondo-Fraire AC, Parant JM, Lozano G. Tissue-specific differences of p53 inhibition by Mdm2 and Mdm4. Mol Cell Biol. 2006 Jan; 26(1):192-8. PMID: 16354690.
      Citations: 83     Fields:    Translation:AnimalsCells
    141. Slack A, Lozano G, Shohet JM. MDM2 as MYCN transcriptional target: implications for neuroblastoma pathogenesis. Cancer Lett. 2005 Oct 18; 228(1-2):21-7. PMID: 15927364.
      Citations: 10     Fields:    Translation:HumansAnimals
    142. Iwakuma T, Lozano G, Flores ER. Li-Fraumeni syndrome: a p53 family affair. Cell Cycle. 2005 Jul; 4(7):865-7. PMID: 15917654.
      Citations: 19     Fields:    Translation:HumansAnimals
    143. Lozano G, Zambetti GP. Gankyrin: an intriguing name for a novel regulator of p53 and RB. Cancer Cell. 2005 Jul; 8(1):3-4. PMID: 16023592.
      Citations: 19     Fields:    Translation:HumansCells
    144. Soussi T, Lozano G. p53 mutation heterogeneity in cancer. Biochem Biophys Res Commun. 2005 Jun 10; 331(3):834-42. PMID: 15865939.
      Citations: 93     Fields:    Translation:HumansAnimals
    145. Huang W, Zhang J, Washington M, Liu J, Parant JM, Lozano G, Moore DD. Xenobiotic stress induces hepatomegaly and liver tumors via the nuclear receptor constitutive androstane receptor. Mol Endocrinol. 2005 Jun; 19(6):1646-53. PMID: 15831521.
      Citations: 100     Fields:    Translation:HumansAnimalsCells
    146. Liu G, Lozano G. p21 stability: linking chaperones to a cell cycle checkpoint. Cancer Cell. 2005 Feb; 7(2):113-4. PMID: 15710322.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    147. Bachinski LL, Olufemi SE, Zhou X, Wu CC, Yip L, Shete S, Lozano G, Amos CI, Strong LC, Krahe R. Genetic mapping of a third Li-Fraumeni syndrome predisposition locus to human chromosome 1q23. Cancer Res. 2005 Jan 15; 65(2):427-31. PMID: 15695383.
      Citations: 13     Fields:    Translation:HumansCells
    148. Lozano G, Zambetti GP. What have animal models taught us about the p53 pathway? J Pathol. 2005 Jan; 205(2):206-20. PMID: 15643668.
      Citations: 27     Fields:    Translation:HumansAnimals
    149. Lang GA, Iwakuma T, Suh YA, Liu G, Rao VA, Parant JM, Valentin-Vega YA, Terzian T, Caldwell LC, Strong LC, El-Naggar AK, Lozano G. Gain of function of a p53 hot spot mutation in a mouse model of Li-Fraumeni syndrome. Cell. 2004 Dec 17; 119(6):861-72. PMID: 15607981.
      Citations: 508     Fields:    Translation:AnimalsCells
    150. Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Res. 2004 Dec 15; 64(24):9080-5. PMID: 15604276.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    151. Bond GL, Hu W, Bond EE, Robins H, Lutzker SG, Arva NC, Bargonetti J, Bartel F, Taubert H, Wuerl P, Onel K, Yip L, Hwang SJ, Strong LC, Lozano G, Levine AJ. A single nucleotide polymorphism in the MDM2 promoter attenuates the p53 tumor suppressor pathway and accelerates tumor formation in humans. Cell. 2004 Nov 24; 119(5):591-602. PMID: 15550242.
      Citations: 504     Fields:    Translation:HumansAnimalsCells
    152. Iwakuma T, Parant JM, Fasulo M, Zwart E, Jacks T, de Vries A, Lozano G. Mutation at p53 serine 389 does not rescue the embryonic lethality in mdm2 or mdm4 null mice. Oncogene. 2004 Oct 07; 23(46):7644-50. PMID: 15361844.
      Citations: 9     Fields:    Translation:AnimalsCells
    153. Bruins W, Zwart E, Attardi LD, Iwakuma T, Hoogervorst EM, Beems RB, Miranda B, van Oostrom CT, van den Berg J, van den Aardweg GJ, Lozano G, van Steeg H, Jacks T, de Vries A. Increased sensitivity to UV radiation in mice with a p53 point mutation at Ser389. Mol Cell Biol. 2004 Oct; 24(20):8884-94. PMID: 15456863.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    154. Barlow JW, Mous M, Wiley JC, Varley JM, Lozano G, Strong LC, Malkin D. Germ line BAX alterations are infrequent in Li-Fraumeni syndrome. Cancer Epidemiol Biomarkers Prev. 2004 Aug; 13(8):1403-6. PMID: 15298965.
      Citations: 4     Fields:    Translation:Humans
    155. Evans SC, Liang M, Amos C, Gu X, Lozano G. A novel genetic modifier of p53, mop1, results in embryonic lethality. Mamm Genome. 2004 Jun; 15(6):415-23. PMID: 15181534.
      Citations: 2     Fields:    Translation:Animals
    156. Obeyesekere MN, Tecarro E, Lozano G. Model predictions of MDM2 mediated cell regulation. Cell Cycle. 2004 May; 3(5):655-61. PMID: 15107623.
      Citations: 2     Fields:    Translation:Cells
    157. Liu G, Parant JM, Lang G, Chau P, Chavez-Reyes A, El-Naggar AK, Multani A, Chang S, Lozano G. Chromosome stability, in the absence of apoptosis, is critical for suppression of tumorigenesis in Trp53 mutant mice. Nat Genet. 2004 Jan; 36(1):63-8. PMID: 14702042.
      Citations: 140     Fields:    Translation:Animals
    158. Chavez-Reyes A, Parant JM, Amelse LL, de Oca Luna RM, Korsmeyer SJ, Lozano G. Switching mechanisms of cell death in mdm2- and mdm4-null mice by deletion of p53 downstream targets. Cancer Res. 2003 Dec 15; 63(24):8664-9. PMID: 14695178.
      Citations: 46     Fields:    Translation:Animals
    159. Wong SS, Lozano G, Gaff CL, Gardner RJ, Strong LC, Aittomäki K, Lindeman GJ. Novel p53 germline mutation in a patient with Li-Fraumeni syndrome. Intern Med J. 2003 Dec; 33(12):621. PMID: 14656244.
      Citations: 1     Fields:    Translation:Humans
    160. Iwakuma T, Lozano G. MDM2, an introduction. Mol Cancer Res. 2003 Dec; 1(14):993-1000. PMID: 14707282.
      Citations: 152     Fields:    Translation:HumansAnimalsCells
    161. Horn EJ, Albor A, Liu Y, El-Hizawi S, Vanderbeek GE, Babcock M, Bowden GT, Hennings H, Lozano G, Weinberg WC, Kulesz-Martin M. RING protein Trim32 associated with skin carcinogenesis has anti-apoptotic and E3-ubiquitin ligase properties. Carcinogenesis. 2004 Feb; 25(2):157-67. PMID: 14578165.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    162. Yang HY, Wen YY, Chen CH, Lozano G, Lee MH. 14-3-3 sigma positively regulates p53 and suppresses tumor growth. Mol Cell Biol. 2003 Oct; 23(20):7096-107. PMID: 14517281.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    163. Hwang SJ, Cheng LS, Lozano G, Amos CI, Gu X, Strong LC. Lung cancer risk in germline p53 mutation carriers: association between an inherited cancer predisposition, cigarette smoking, and cancer risk. Hum Genet. 2003 Aug; 113(3):238-43. PMID: 12802680.
      Citations: 38     Fields:    Translation:Humans
    164. Leng RP, Lin Y, Ma W, Wu H, Lemmers B, Chung S, Parant JM, Lozano G, Hakem R, Benchimol S. Pirh2, a p53-induced ubiquitin-protein ligase, promotes p53 degradation. Cell. 2003 Mar 21; 112(6):779-91. PMID: 12654245.
      Citations: 293     Fields:    Translation:HumansAnimalsCells
    165. Parant JM, Lozano G. Disrupting TP53 in mouse models of human cancers. Hum Mutat. 2003 Mar; 21(3):321-6. PMID: 12619119.
      Citations: 8     Fields:    Translation:HumansAnimals
    166. Hwang SJ, Lozano G, Amos CI, Strong LC. Germline p53 mutations in a cohort with childhood sarcoma: sex differences in cancer risk. Am J Hum Genet. 2003 Apr; 72(4):975-83. PMID: 12610779.
      Citations: 73     Fields:    Translation:Humans
    167. Lu X, Lozano G, Donehower LA. Activities of wildtype and mutant p53 in suppression of homologous recombination as measured by a retroviral vector system. Mutat Res. 2003 Jan 28; 522(1-2):69-83. PMID: 12517413.
      Citations: 13     Fields:    Translation:HumansCells
    168. Budhram-Mahadeo V, Morris P, Ndisang D, Irshad S, Lozano G, Pedley B, Latchman DS. The Brn-3a POU family transcription factor stimulates p53 gene expression in human and mouse tumour cells. Neurosci Lett. 2002 Dec 06; 334(1):1-4. PMID: 12431761.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    169. Martinez LA, Naguibneva I, Lehrmann H, Vervisch A, Tchénio T, Lozano G, Harel-Bellan A. Synthetic small inhibiting RNAs: efficient tools to inactivate oncogenic mutations and restore p53 pathways. Proc Natl Acad Sci U S A. 2002 Nov 12; 99(23):14849-54. PMID: 12403821.
      Citations: 59     Fields:    Translation:HumansCells
    170. Jabbur JR, Tabor AD, Cheng X, Wang H, Uesugi M, Lozano G, Zhang W. Mdm-2 binding and TAF(II)31 recruitment is regulated by hydrogen bond disruption between the p53 residues Thr18 and Asp21. Oncogene. 2002 Oct 10; 21(46):7100-13. PMID: 12370832.
      Citations: 20     Fields:    Translation:HumansCells
    171. Foster CJ, Lozano G. Loss of p19ARF enhances the defects of Mdm2 overexpression in the mammary gland. Oncogene. 2002 May 16; 21(22):3525-31. PMID: 12032854.
      Citations: 5     Fields:    Translation:AnimalsCells
    172. Santamaria AB, Davis DW, Nghiem DX, McConkey DJ, Ullrich SE, Kapoor M, Lozano G, Ananthaswamy HN. p53 and Fas ligand are required for psoralen and UVA-induced apoptosis in mouse epidermal cells. Cell Death Differ. 2002 May; 9(5):549-60. PMID: 11973613.
      Citations: 13     Fields:    Translation:AnimalsCells
    173. Gu J, Kawai H, Nie L, Kitao H, Wiederschain D, Jochemsen AG, Parant J, Lozano G, Yuan ZM. Mutual dependence of MDM2 and MDMX in their functional inactivation of p53. J Biol Chem. 2002 May 31; 277(22):19251-4. PMID: 11953423.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    174. Grier JD, Yan W, Lozano G. Conditional allele of mdm2 which encodes a p53 inhibitor. Genesis. 2002 Feb; 32(2):145-7. PMID: 11857803.
      Citations: 27     Fields:    Translation:Animals
    175. Schmidt M, Lu Y, Parant JM, Lozano G, Bacher G, Beckers T, Fan Z. Differential roles of p21(Waf1) and p27(Kip1) in modulating chemosensitivity and their possible application in drug discovery studies. Mol Pharmacol. 2001 Nov; 60(5):900-6. PMID: 11641417.
      Citations: 10     Fields:    Translation:HumansCells
    176. Parant J, Chavez-Reyes A, Little NA, Yan W, Reinke V, Jochemsen AG, Lozano G. Rescue of embryonic lethality in Mdm4-null mice by loss of Trp53 suggests a nonoverlapping pathway with MDM2 to regulate p53. Nat Genet. 2001 Sep; 29(1):92-5. PMID: 11528400.
      Citations: 253     Fields:    Translation:AnimalsCells
    177. Evans SC, Viswanathan M, Grier JD, Narayana M, El-Naggar AK, Lozano G. An alternatively spliced HDM2 product increases p53 activity by inhibiting HDM2. Oncogene. 2001 Jul 05; 20(30):4041-9. PMID: 11494132.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    178. Parant JM, Reinke V, Mims B, Lozano G. Organization, expression, and localization of the murine mdmx gene and pseudogene. Gene. 2001 May 30; 270(1-2):277-83. PMID: 11404026.
      Citations: 8     Fields:    Translation:AnimalsCells
    179. El-Naggar AK, Lai S, Clayman GL, Mims B, Lippman SM, Coombes M, Luna MA, Lozano G. p73 gene alterations and expression in primary oral and laryngeal squamous carcinomas. Carcinogenesis. 2001 May; 22(5):729-35. PMID: 11323391.
      Citations: 5     Fields:    Translation:HumansCells
    180. Keller DM, Zeng X, Wang Y, Zhang QH, Kapoor M, Shu H, Goodman R, Lozano G, Zhao Y, Lu H. A DNA damage-induced p53 serine 392 kinase complex contains CK2, hSpt16, and SSRP1. Mol Cell. 2001 Feb; 7(2):283-92. PMID: 11239457.
      Citations: 110     Fields:    Translation:HumansCells
    181. Huang W, Wang SL, Lozano G, de Crombrugghe B. cDNA library screening using the SOS recruitment system. Biotechniques. 2001 Jan; 30(1):94-8, 100. PMID: 11196326.
      Citations: 7     Fields:    Translation:AnimalsCells
    182. Weber JD, Jeffers JR, Rehg JE, Randle DH, Lozano G, Roussel MF, Sherr CJ, Zambetti GP. p53-independent functions of the p19(ARF) tumor suppressor. Genes Dev. 2000 Sep 15; 14(18):2358-65. PMID: 10995391.
      Citations: 130     Fields:    Translation:AnimalsCells
    183. Liu G, McDonnell TJ, Montes de Oca Luna R, Kapoor M, Mims B, El-Naggar AK, Lozano G. High metastatic potential in mice inheriting a targeted p53 missense mutation. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4174-9. PMID: 10760284.
      Citations: 72     Fields:    Translation:HumansAnimalsCells
    184. de Rozieres S, Maya R, Oren M, Lozano G. The loss of mdm2 induces p53-mediated apoptosis. Oncogene. 2000 Mar 23; 19(13):1691-7. PMID: 10763826.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    185. Lozano G, Elledge SJ. p53 sends nucleotides to repair DNA. Nature. 2000 Mar 02; 404(6773):24-5. PMID: 10716425.
      Citations: 21     Fields:    Translation:HumansCells
    186. Kapoor M, Hamm R, Yan W, Taya Y, Lozano G. Cooperative phosphorylation at multiple sites is required to activate p53 in response to UV radiation. Oncogene. 2000 Jan 20; 19(3):358-64. PMID: 10656682.
      Citations: 23     Fields:    Translation:HumansCells
    187. Casau AE, Vaughan JE, Lozano G, Levine AJ. Germ cell expression of an isolated human endogenous retroviral long terminal repeat of the HERV-K/HTDV family in transgenic mice. J Virol. 1999 Dec; 73(12):9976-83. PMID: 10559311.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    188. Keller D, Zeng X, Li X, Kapoor M, Iordanov MS, Taya Y, Lozano G, Magun B, Lu H. The p38MAPK inhibitor SB203580 alleviates ultraviolet-induced phosphorylation at serine 389 but not serine 15 and activation of p53. Biochem Biophys Res Commun. 1999 Aug 02; 261(2):464-71. PMID: 10425208.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    189. McDonnell TJ, Montes de Oca Luna R, Cho S, Amelse LL, Chavez-Reyes A, Lozano G. Loss of one but not two mdm2 null alleles alters the tumour spectrum in p53 null mice. J Pathol. 1999 Jul; 188(3):322-8. PMID: 10419603.
      Citations: 27     Fields:    Translation:Animals
    190. Evans SC, Foster CJ, El-Naggar AK, Lozano G. Mapping and mutational analysis of the human TAF2G gene encoding a p53 cofactor. Genomics. 1999 Apr 01; 57(1):182-3. PMID: 10191103.
      Citations: 1     Fields:    Translation:HumansCells
    191. Unger T, Juven-Gershon T, Moallem E, Berger M, Vogt Sionov R, Lozano G, Oren M, Haupt Y. Critical role for Ser20 of human p53 in the negative regulation of p53 by Mdm2. EMBO J. 1999 Apr 01; 18(7):1805-14. PMID: 10202144.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    192. Reinke V, Bortner DM, Amelse LL, Lundgren K, Rosenberg MP, Finlay CA, Lozano G. Overproduction of MDM2 in vivo disrupts S phase independent of E2F1. Cell Growth Differ. 1999 Mar; 10(3):147-54. PMID: 10099828.
      Citations: 8     Fields:    Translation:AnimalsCells
    193. Hung J, Mims B, Lozano G, Strong L, Harvey C, Chen TT, Stastny V, Tomlinson G. TP53 mutation and haplotype analysis of two large African American families. Hum Mutat. 1999; 14(3):216-21. PMID: 10477429.
      Citations: 2     Fields:    Translation:Humans
    194. Kapoor M, Montes de Oca Luna R, Liu G, Lozano G, Cummings C, Mancini M, Ouspenski I, Brinkley BR, May GS. The cenpB gene is not essential in mice. Chromosoma. 1998 Dec; 107(8):570-6. PMID: 9933410.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    195. Zou Y, Zong G, Ling YH, Hao MM, Lozano G, Hong WK, Perez-Soler R. Effective treatment of early endobronchial cancer with regional administration of liposome-p53 complexes. J Natl Cancer Inst. 1998 Aug 05; 90(15):1130-7. PMID: 9701362.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    196. Evans SC, Mims B, McMasters KM, Foster CJ, deAndrade M, Amos CI, Strong LC, Lozano G. Exclusion of a p53 germline mutation in a classic Li-Fraumeni syndrome family. Hum Genet. 1998 Jun; 102(6):681-6. PMID: 9703430.
      Citations: 8     Fields:    Translation:HumansAnimals
    197. Anaya P, Evans SC, Dai C, Lozano G, May GS. Isolation of the Aspergillus nidulans sudD gene and its human homologue. Gene. 1998 May 12; 211(2):323-9. PMID: 9602165.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    198. Lozano G, Montes de Oca Luna R. MDM2 function. Biochim Biophys Acta. 1998 Apr 17; 1377(2):M55-9. PMID: 9606977.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    199. Kapoor M, Lozano G. Functional activation of p53 via phosphorylation following DNA damage by UV but not gamma radiation. Proc Natl Acad Sci U S A. 1998 Mar 17; 95(6):2834-7. PMID: 9501176.
      Citations: 63     Fields:    Translation:AnimalsCells
    200. Siddik ZH, Mims B, Lozano G, Thai G. Independent pathways of p53 induction by cisplatin and X-rays in a cisplatin-resistant ovarian tumor cell line. Cancer Res. 1998 Feb 15; 58(4):698-703. PMID: 9485023.
      Citations: 23     Fields:    Translation:HumansCells
    201. Lozano G, Liu G. Mouse models dissect the role of p53 in cancer and development. Semin Cancer Biol. 1998; 8(5):337-44. PMID: 10101799.
      Citations: 9     Fields:    Translation:Animals
    202. Beham A, Marin MC, Fernandez A, Herrmann J, Brisbay S, Tari AM, Lopez-Berestein G, Lozano G, Sarkiss M, McDonnell TJ. Bcl-2 inhibits p53 nuclear import following DNA damage. Oncogene. 1997 Dec 04; 15(23):2767-72. PMID: 9419967.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    203. Reinke V, Lozano G. The p53 targets mdm2 and Fas are not required as mediators of apoptosis in vivo. Oncogene. 1997 Sep 25; 15(13):1527-34. PMID: 9380404.
      Citations: 9     Fields:    Translation:Animals
    204. Evans SC, Lozano G. The Li-Fraumeni syndrome: an inherited susceptibility to cancer. Mol Med Today. 1997 Sep; 3(9):390-5. PMID: 9302689.
      Citations: 9     Fields:    Translation:HumansCells
    205. Montes de Oca Luna R, Amelse LL, Chavez-Reyes A, Evans SC, Brugarolas J, Jacks T, Lozano G. Deletion of p21 cannot substitute for p53 loss in rescue of mdm2 null lethality. Nat Genet. 1997 Aug; 16(4):336-7. PMID: 9241268.
      Citations: 4     Fields:    Translation:AnimalsCells
    206. Reinke V, Lozano G. Differential activation of p53 targets in cells treated with ultraviolet radiation that undergo both apoptosis and growth arrest. Radiat Res. 1997 Aug; 148(2):115-22. PMID: 9254729.
      Citations: 14     Fields:    Translation:AnimalsCells
    207. Lundgren K, Montes de Oca Luna R, McNeill YB, Emerick EP, Spencer B, Barfield CR, Lozano G, Rosenberg MP, Finlay CA. Targeted expression of MDM2 uncouples S phase from mitosis and inhibits mammary gland development independent of p53. Genes Dev. 1997 Mar 15; 11(6):714-25. PMID: 9087426.
      Citations: 84     Fields:    Translation:AnimalsCells
    208. Ruifrok AC, Mason KA, Lozano G, Thames HD. Spatial and temporal patterns of expression of epidermal growth factor, transforming growth factor alpha and transforming growth factor beta 1-3 and their receptors in mouse jejunum after radiation treatment. Radiat Res. 1997 Jan; 147(1):1-12. PMID: 8989363.
      Citations: 9     Fields:    Translation:Animals
    209. Hao M, Lowy AM, Kapoor M, Deffie A, Liu G, Lozano G. Mutation of phosphoserine 389 affects p53 function in vivo. J Biol Chem. 1996 Nov 15; 271(46):29380-5. PMID: 8910602.
      Citations: 28     Fields:    Translation:AnimalsCells
    210. McMasters KM, Montes de Oca Luna R, Peña JR, Lozano G. mdm2 deletion does not alter growth characteristics of p53-deficient embryo fibroblasts. Oncogene. 1996 Oct 17; 13(8):1731-6. PMID: 8895519.
      Citations: 25     Fields:    Translation:Animals
    211. Davis P, Bazar K, Huper G, Lozano G, Marks J, Iglehart JD. Dominance of wild-type p53-mediated transcriptional activation in breast epithelial cells. Oncogene. 1996 Sep 19; 13(6):1315-22. PMID: 8808706.
      Citations: 3     Fields:    Translation:HumansCells
    212. de Oca Luna RM, Tabor AD, Eberspaecher H, Hulboy DL, Worth LL, Colman MS, Finlay CA, Lozano G. The organization and expression of the mdm2 gene. Genomics. 1996 May 01; 33(3):352-7. PMID: 8660994.
      Citations: 8     Fields:    Translation:AnimalsCells
    213. Montes de Oca Luna R, Wagner DS, Lozano G. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature. 1995 Nov 09; 378(6553):203-6. PMID: 7477326.
      Citations: 584     Fields:    Translation:AnimalsCells
    214. de Vente JE, Kukoly CA, Bryant WO, Posekany KJ, Chen J, Fletcher DJ, Parker PJ, Pettit GJ, Lozano G, Cook PP, et al. Phorbol esters induce death in MCF-7 breast cancer cells with altered expression of protein kinase C isoforms. Role for p53-independent induction of gadd-45 in initiating death. J Clin Invest. 1995 Oct; 96(4):1874-86. PMID: 7560079.
      Citations: 12     Fields:    Translation:HumansCells
    215. Ghebranious N, Knoll BJ, Yavorkovsky L, Ilic Z, Papaconstantinou J, Lozano G, Sell S. Developmental control of transcription of the CAT reporter gene by a truncated mouse alphafetoprotein gene regulatory region in transgenic mice. Mol Reprod Dev. 1995 Sep; 42(1):1-6. PMID: 8562043.
      Citations: 1     Fields:    Translation:AnimalsCells
    216. Deffie A, Hao M, Montes de Oca Luna R, Hulboy DL, Lozano G. Cyclin E restores p53 activity in contact-inhibited cells. Mol Cell Biol. 1995 Jul; 15(7):3926-33. PMID: 7791798.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    217. Ghebranious N, Knoll BJ, Wu H, Lozano G, Sell S. Characterization of a murine p53ser246 mutant equivalent to the human p53ser249 associated with hepatocellular carcinoma and aflatoxin exposure. Mol Carcinog. 1995 Jun; 13(2):104-11. PMID: 7605578.
      Citations:    Fields:    Translation:HumansAnimalsCells
    218. Hulboy DL, Lozano G. Structural and functional analysis of p53: the acidic activation domain has transforming capability. Cell Growth Differ. 1994 Oct; 5(10):1023-31. PMID: 7848903.
      Citations: 6     Fields:    Translation:HumansCells
    219. Mu ZM, Chin KV, Liu JH, Lozano G, Chang KS. PML, a growth suppressor disrupted in acute promyelocytic leukemia. Mol Cell Biol. 1994 Oct; 14(10):6858-67. PMID: 7935403.
      Citations: 74     Fields:    Translation:HumansAnimalsCells
    220. Wu H, Lozano G. NF-kappa B activation of p53. A potential mechanism for suppressing cell growth in response to stress. J Biol Chem. 1994 Aug 05; 269(31):20067-74. PMID: 8051093.
      Citations: 86     Fields:    Translation:HumansCells
    221. Jiang D, Srinivasan A, Lozano G, Robbins PD. SV40 T antigen abrogates p53-mediated transcriptional activity. Oncogene. 1993 Oct; 8(10):2805-12. PMID: 8378089.
      Citations: 43     Fields:    Translation:AnimalsCells
    222. Deffie A, Wu H, Reinke V, Lozano G. The tumor suppressor p53 regulates its own transcription. Mol Cell Biol. 1993 Jun; 13(6):3415-23. PMID: 7684498.
      Citations: 33     Fields:    Translation:AnimalsCells
    223. Hao M, Finlay CA, Lozano G. A functionally inactive p53 Li-Fraumeni syndrome mutant. Oncogene. 1993 Feb; 8(2):299-306. PMID: 8426739.
      Citations: 1     Fields:    Translation:HumansCells
    224. Goldberg H, Helaakoski T, Garrett LA, Karsenty G, Pellegrino A, Lozano G, Maity S, de Crombrugghe B. Tissue-specific expression of the mouse alpha 2(I) collagen promoter. Studies in transgenic mice and in tissue culture cells. J Biol Chem. 1992 Sep 25; 267(27):19622-30. PMID: 1527081.
      Citations: 23     Fields:    Translation:AnimalsCells
    225. Raycroft L, Lozano G. A convenient cloning vector containing the GAL4 DNA-binding domain. Gene. 1992 Sep 01; 118(1):143-4. PMID: 1511878.
      Citations:    Fields:    Translation:Cells
    226. Beenken SW, Raycroft L, Lozano G. Inhibition of the mutant p53 gene in transformation assays. J Surg Res. 1992 Apr; 52(4):401-5. PMID: 1593878.
      Citations:    Fields:    Translation:AnimalsCells
    227. Raycroft L, Schmidt JR, Yoas K, Hao MM, Lozano G. Analysis of p53 mutants for transcriptional activity. Mol Cell Biol. 1991 Dec; 11(12):6067-74. PMID: 1944276.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    228. Garofalo S, Vuorio E, Metsaranta M, Rosati R, Toman D, Vaughan J, Lozano G, Mayne R, Ellard J, Horton W, et al. Reduced amounts of cartilage collagen fibrils and growth plate anomalies in transgenic mice harboring a glycine-to-cysteine mutation in the mouse type II procollagen alpha 1-chain gene. Proc Natl Acad Sci U S A. 1991 Nov 01; 88(21):9648-52. PMID: 1946380.
      Citations: 33     Fields:    Translation:AnimalsCells
    229. Beenken SW, Karsenty G, Raycroft L, Lozano G. An intron binding protein is required for transformation ability of p53. Nucleic Acids Res. 1991 Sep 11; 19(17):4747-52. PMID: 1891364.
      Citations: 7     Fields:    Translation:AnimalsCells
    230. Lozano G, Levine AJ. Tissue-specific expression of p53 in transgenic mice is regulated by intron sequences. Mol Carcinog. 1991; 4(1):3-9. PMID: 1848986.
      Citations: 20     Fields:    Translation:AnimalsCells
    231. Raycroft L, Wu HY, Lozano G. Transcriptional activation by wild-type but not transforming mutants of the p53 anti-oncogene. Science. 1990 Aug 31; 249(4972):1049-51. PMID: 2144364.
      Citations: 188     Fields:    Translation:HumansCells
    232. De Crombrugghe B, Karsenty G, Maity S, Vuorio T, Rossi P, Ruteshouser EC, McKinney SH, Lozano G. Transcriptional mechanisms controlling types I and III collagen genes. Ann N Y Acad Sci. 1990; 580:88-96. PMID: 2337308.
      Citations: 4     Fields:    Translation:AnimalsCells
    233. Marks J, Lin J, Miller D, Lozano G, Herbert J, Levine AJ. The expression of viral and cellular genes in papillomas of the choroid plexus induced in transgenic mice. Prog Clin Biol Res. 1988; 284:163-86. PMID: 2851142.
      Citations: 1     Fields:    Translation:AnimalsCells
    234. Van Dyke TA, Finlay C, Miller D, Marks J, Lozano G, Levine AJ. Relationship between simian virus 40 large tumor antigen expression and tumor formation in transgenic mice. J Virol. 1987 Jun; 61(6):2029-32. PMID: 3033329.
      Citations: 30     Fields:    Translation:AnimalsCells
    235. McCormick D, van der Rest M, Goodship J, Lozano G, Ninomiya Y, Olsen BR. Structure of the glycosaminoglycan domain in the type IX collagen-proteoglycan. Proc Natl Acad Sci U S A. 1987 Jun; 84(12):4044-8. PMID: 3473493.
      Citations: 14     Fields:    Translation:AnimalsCells
    236. Yagaloff KA, Lozano G, van Dyke T, Levine AJ, Hartig PR. Serotonin 5-HT1C receptors are expressed at high density on choroid plexus tumors from transgenic mice. Brain Res. 1986 Oct 22; 385(2):389-94. PMID: 3022874.
      Citations: 5     Fields:    Translation:AnimalsCells
    237. Lozano G, Ninomiya Y, Olsen BR. The structure of short-chain collagen genes. Prog Clin Biol Res. 1986; 217B:397-400. PMID: 3755828.
      Citations:    Fields:    Translation:AnimalsCells
    238. Ninomiya Y, van der Rest M, Mayne R, Lozano G, Olsen BR. Construction and characterization of cDNA encoding the alpha 2 chain of chicken type IX collagen. Biochemistry. 1985 Jul 16; 24(15):4223-9. PMID: 2996593.
      Citations: 8     Fields:    Translation:AnimalsCells
    239. Lozano G, Ninomiya Y, Thompson H, Olsen BR. A distinct class of vertebrate collagen genes encodes chicken type IX collagen polypeptides. Proc Natl Acad Sci U S A. 1985 Jun; 82(12):4050-4. PMID: 3858862.
      Citations: 15     Fields:    Translation:AnimalsCells
    240. Olsen BR, Ninomiya Y, Lozano G, Konomi H, Gordon M, Green G, Parsons J, Seyer J, Thompson H, Vasios G. Short-chain collagen genes and their expression in cartilage. Ann N Y Acad Sci. 1985; 460:141-53. PMID: 3868942.
      Citations: 6     Fields:    Translation:AnimalsCells
    241. Vogeli G, Avvedimento EV, Sullivan M, Maizel JV, Lozano G, Adams SL, Pastan I, de Crombrugghe B. Isolation and characterization of genomic DNA coding for alpha 2 type I collagen. Nucleic Acids Res. 1980 Apr 25; 8(8):1823-37. PMID: 7433131.
      Citations: 11     Fields:    Translation:AnimalsCells
    242. Lack of immunomodulatory interleukin-27 enhances oncogenic properties of mutant p53 in vivo. Clinical Cancer Research. 22:3876-3883.
    243. Signals regulating p53- and Rb-mediated negative cell growth. Cancer Bulletin. 47:158-162.
    244. Transcriptional Regulation by Tumor Suppressor Genes. Methods. 8:215-224.
    245. Mutant p53 Prolongs NF-kB activation and promotes chronic inflammation and inflammation-associated colorectal cancer. Cancer Cell. 24:272.
    246. Novel MYBL1 Gene Rearrangements with Recurrent MYBL1-NFIB Fusions in Salivary Adenoid Cystic Carcinomas Lacking t(6;9) Translocations. Clinical Cancer Research. 22:725-733.
    247. Nuclear protein binds intron 4 of the p53 oncogene. Surgical Forum. 40:450-452.
    248. Attenuating the p53 pathway in human cancers. Cold Spring Harbor perspectives in medicine. 6.
    249. p53 activity dominates that of p73 upon Mdm4 loss in development and tumorigenesis. Molecular Cancer Research. 14:56-65.
    250. Distinct downstream targets manifest p53-dependent pathologies in mice. Oncogene.
    251. Mutant p53 accumulates in cycling and proliferating cells in the normal tissues of p53 R172H mutant mice. Oncotarget. 6:17968-17980.
    252. Mutant p53 in concert with an interleukin-27 receptor alpha deficiency causes spontaneous liver inflammation, fibrosis, and steatosis in mice. Hepatology.
    253. MDM4/HIPK2/p53 cytoplasmic assembly uncovers coordinated repression of molecules with anti-apoptotic activity during early DNA damage response. Oncogene. 35:228-240.
    254. Mutant p53-driven tumorigenesis. 77-93.
    255. Novel p53 target genes secreted by the liver are involved in non-cell-autonomous regulation. Cell Death and Differentiation. 23:509-520.
    256. The p53 inhibitor Mdm4 cooperates with multiple genetic lesions in tumourigenesis. Journal of Pathology.
    257. Functional characterization of inherited p53 mutations. Cancer Bulletin. 46:247-253.
    258. Comparison of sample-labeling techniques in DNA microarray experiments. Analytica Chimica Acta. 506:117-125.
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