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WALDEMAR PRIEBE

TitleProfessor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1901 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Shingu T, Holmes L, Henry V, Wang Q, Latha K, Gururaj AE, Gibson LA, Doucette T, Lang FF, Rao G, Yuan L, Sulman EP, Farrell NP, Priebe W, Hess KR, Wang YA, Hu J, Bögler O. Suppression of RAF/MEK or PI3K synergizes cytotoxicity of receptor tyrosine kinase inhibitors in glioma tumor-initiating cells. J Transl Med. 2016; 14:46. PMID: 26861698; PMCID: PMC4746796.
    2. Priebe W. Obituary: Derek Horton (1933-2015). Glycoconj J. 2015 Nov; 32(8):557-8. PMID: 26498188.
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    3. Hossain A, Gumin J, Gao F, Figueroa J, Shinojima N, Takezaki T, Priebe W, Villarreal D, Kang SG, Joyce C, Sulman E, Wang Q, Marini FC, Andreeff M, Colman H, Lang FF. Mesenchymal Stem Cells Isolated From Human Gliomas Increase Proliferation and Maintain Stemness of Glioma Stem Cells Through the IL-6/gp130/STAT3 Pathway. Stem Cells. 2015 Aug; 33(8):2400-15. PMID: 25966666.
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    4. Lee HT, Xue J, Chou PC, Zhou A, Yang P, Conrad CA, Aldape KD, Priebe W, Patterson C, Sawaya R, Xie K, Huang S. Stat3 orchestrates interaction between endothelial and tumor cells and inhibition of Stat3 suppresses brain metastasis of breast cancer cells. Oncotarget. 2015 Apr 30; 6(12):10016-29. PMID: 25881542.
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    5. Mansilla S, Vizcaíno C, Rodríguez-Sánchez MA, Priebe W, Portugal J. Autophagy modulates the effects of bis-anthracycline WP631 on p53-deficient prostate cancer cells. J Cell Mol Med. 2015 Apr; 19(4):786-98. PMID: 25689150.
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    6. Kong LY, Wei J, Haider AS, Liebelt BD, Ling X, Conrad CA, Fuller GN, Levine NB, Priebe W, Sawaya R, Heimberger AB. Therapeutic targets in subependymoma. J Neuroimmunol. 2014 Dec 15; 277(1-2):168-75. PMID: 25465288.
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    7. Judd LM, Menheniott TR, Ling H, Jackson CB, Howlett M, Kalantzis A, Priebe W, Giraud AS. Inhibition of the JAK2/STAT3 pathway reduces gastric cancer growth in vitro and in vivo. PLoS One. 2014; 9(5):e95993. PMID: 24804649.
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    8. Emmett MR, Kroes RA, Moskal JR, Conrad CA, Priebe W, Laezza F, Meyer-Baese A, Nilsson CL. Integrative biological analysis for neuropsychopharmacology. Neuropsychopharmacology. 2014 Jan; 39(1):5-23. PMID: 23800968; PMCID: PMC3857644.
    9. Mielecki M, Krawiec K, Kiburu I, Grzelak K, Zagórski W, Kierdaszuk B, Kowa K, Fokt I, Szymanski S, Swierk P, Szeja W, Priebe W, Lesyng B, LaRonde-LeBlanc N. Development of novel molecular probes of the Rio1 atypical protein kinase. Biochim Biophys Acta. 2013 Jul; 1834(7):1292-301. PMID: 23523885.
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    10. Garnett J, Chumbalkar V, Vaillant B, Gururaj AE, Hill KS, Latha K, Yao J, Priebe W, Colman H, Elferink LA, Bogler O. Regulation of HGF expression by ?EGFR-mediated c-Met activation in glioblastoma cells. Neoplasia. 2013 Jan; 15(1):73-84. PMID: 23359207; PMCID: PMC3556940.
    11. Fokt I, Skora S, Conrad C, Madden T, Emmett M, Priebe W. D-Glucose and D-mannose-based metabolic probes. Part 3: Synthesis of specifically deuterated D-glucose, D-mannose, and 2-deoxy-D-glucose. Carbohydr Res. 2013 Mar 7; 368:111-9. PMID: 23376241; PMCID: PMC3893820.
    12. Doucette TA, Kong LY, Yang Y, Ferguson SD, Yang J, Wei J, Qiao W, Fuller GN, Bhat KP, Aldape K, Priebe W, Bögler O, Heimberger AB, Rao G. Signal transducer and activator of transcription 3 promotes angiogenesis and drives malignant progression in glioma. Neuro Oncol. 2012 Sep; 14(9):1136-45. PMID: 22753228; PMCID: PMC3424209.
    13. Swiatek-Machado K, Mieczkowski J, Ellert-Miklaszewska A, Swierk P, Fokt I, Szymanski S, Skora S, Szeja W, Grynkiewicz G, Lesyng B, Priebe W, Kaminska B. Novel small molecular inhibitors disrupt the JAK/STAT3 and FAK signaling pathways and exhibit a potent antitumor activity in glioma cells. Cancer Biol Ther. 2012 Jun; 13(8):657-70. PMID: 22555804.
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    14. Sai K, Wang S, Balasubramaniyan V, Conrad C, Lang FF, Aldape K, Szymanski S, Fokt I, Dasgupta A, Madden T, Guan S, Chen Z, Alfred Yung WK, Priebe W, Colman H. Induction of cell-cycle arrest and apoptosis in glioblastoma stem-like cells by WP1193, a novel small molecule inhibitor of the JAK2/STAT3 pathway. J Neurooncol. 2012 May; 107(3):487-501. PMID: 22249692.
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    15. Yan H, Chen X, Zhang Q, Qin J, Li H, Liu C, Calhoun-Davis T, Coletta LD, Klostergaard J, Fokt I, Skora S, Priebe W, Bi Y, Tang DG. Drug-tolerant cancer cells show reduced tumor-initiating capacity: depletion of CD44 cells and evidence for epigenetic mechanisms. PLoS One. 2011; 6(9):e24397. PMID: 21935404.
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    16. Atkinson JM, Shelat AA, Carcaboso AM, Kranenburg TA, Arnold LA, Boulos N, Wright K, Johnson RA, Poppleton H, Mohankumar KM, Féau C, Phoenix T, Gibson P, Zhu L, Tong Y, Eden C, Ellison DW, Priebe W, Koul D, Yung WK, Gajjar A, Stewart CF, Guy RK, Gilbertson RJ. An integrated in vitro and in vivo high-throughput screen identifies treatment leads for ependymoma. Cancer Cell. 2011 Sep 13; 20(3):384-99. PMID: 21907928; PMCID: PMC3172881.
    17. Hatiboglu MA, Kong LY, Wei J, Wang Y, McEnery KA, Fuller GN, Qiao W, Davies MA, Priebe W, Heimberger AB. The tumor microenvironment expression of p-STAT3 influences the efficacy of cyclophosphamide with WP1066 in murine melanoma models. Int J Cancer. 2012 Jul 1; 131(1):8-17. PMID: 21792892; PMCID: PMC3319790.
    18. Kapuria V, Levitzki A, Bornmann WG, Maxwell D, Priebe W, Sorenson RJ, Showalter HD, Talpaz M, Donato NJ. A novel small molecule deubiquitinase inhibitor blocks Jak2 signaling through Jak2 ubiquitination. Cell Signal. 2011 Dec; 23(12):2076-85. PMID: 21855629.
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    19. Mansilla S, Priebe W, Portugal J. Changes in gene expression induced by Sp1 knockdown differ from those caused by challenging Sp1 binding to gene promoters. Biochim Biophys Acta. 2011 Jul; 1809(7):327-36. PMID: 21684359.
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    20. Ahmed AA, Goldsmith J, Fokt I, Le XF, Krzysko KA, Lesyng B, Bast RC, Priebe W. A genistein derivative, ITB-301, induces microtubule depolymerization and mitotic arrest in multidrug-resistant ovarian cancer. Cancer Chemother Pharmacol. 2011 Oct; 68(4):1033-44. PMID: 21340606; PMCID: PMC3180612.
    21. Wei J, Wu A, Kong LY, Wang Y, Fuller G, Fokt I, Melillo G, Priebe W, Heimberger AB. Hypoxia potentiates glioma-mediated immunosuppression. PLoS One. 2011; 6(1):e16195. PMID: 21283755; PMCID: PMC3024401.
    22. Sandulache VC, Ow TJ, Pickering CR, Frederick MJ, Zhou G, Fokt I, Davis-Malesevich M, Priebe W, Myers JN. Glucose, not glutamine, is the dominant energy source required for proliferation and survival of head and neck squamous carcinoma cells. Cancer. 2011 Jul 1; 117(13):2926-38. PMID: 21692052; PMCID: PMC3135768.
    23. Samanta A, Perazzona B, Chakraborty S, Sun X, Modi H, Bhatia R, Priebe W, Arlinghaus R. Janus kinase 2 regulates Bcr-Abl signaling in chronic myeloid leukemia. Leukemia. 2011 Mar; 25(3):463-72. PMID: 21183952.
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    24. Kong LY, Wu AS, Doucette T, Wei J, Priebe W, Fuller GN, Qiao W, Sawaya R, Rao G, Heimberger AB. Intratumoral mediated immunosuppression is prognostic in genetically engineered murine models of glioma and correlates to immunotherapeutic responses. Clin Cancer Res. 2010 Dec 1; 16(23):5722-33. PMID: 20921210; PMCID: PMC2999668.
    25. Wu A, Wei J, Kong LY, Wang Y, Priebe W, Qiao W, Sawaya R, Heimberger AB. Glioma cancer stem cells induce immunosuppressive macrophages/microglia. Neuro Oncol. 2010 Nov; 12(11):1113-25. PMID: 20667896; PMCID: PMC3098021.
    26. Pham LV, Tamayo AT, Li C, Bornmann W, Priebe W, Ford RJ. Degrasyn potentiates the antitumor effects of bortezomib in mantle cell lymphoma cells in vitro and in vivo: therapeutic implications. Mol Cancer Ther. 2010 Jul; 9(7):2026-36. PMID: 20606045.
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    27. He H, Nilsson CL, Emmett MR, Marshall AG, Kroes RA, Moskal JR, Ji Y, Colman H, Priebe W, Lang FF, Conrad CA. Glycomic and transcriptomic response of GSC11 glioblastoma stem cells to STAT3 phosphorylation inhibition and serum-induced differentiation. J Proteome Res. 2010 May 7; 9(5):2098-108. PMID: 20199106.
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    28. Kong LY, Gelbard A, Wei J, Reina-Ortiz C, Wang Y, Yang EC, Hailemichael Y, Fokt I, Jayakumar A, Qiao W, Fuller GN, Overwijk WW, Priebe W, Heimberger AB. Inhibition of p-STAT3 enhances IFN-alpha efficacy against metastatic melanoma in a murine model. Clin Cancer Res. 2010 May 1; 16(9):2550-61. PMID: 20388845; PMCID: PMC2936966.
    29. Wei J, Barr J, Kong LY, Wang Y, Wu A, Sharma AK, Gumin J, Henry V, Colman H, Priebe W, Sawaya R, Lang FF, Heimberger AB. Glioblastoma cancer-initiating cells inhibit T-cell proliferation and effector responses by the signal transducers and activators of transcription 3 pathway. Mol Cancer Ther. 2010 Jan; 9(1):67-78. PMID: 20053772; PMCID: PMC2939737.
    30. Nilsson CL, Dillon R, Devakumar A, Shi SD, Greig M, Rogers JC, Krastins B, Rosenblatt M, Kilmer G, Major M, Kaboord BJ, Sarracino D, Rezai T, Prakash A, Lopez M, Ji Y, Priebe W, Lang FF, Colman H, Conrad CA. Quantitative phosphoproteomic analysis of the STAT3/IL-6/HIF1alpha signaling network: an initial study in GSC11 glioblastoma stem cells. J Proteome Res. 2010 Jan; 9(1):430-43. PMID: 19899826.
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    31. Fokt I, Szymanski S, Skora S, Cybulski M, Madden T, Priebe W. D-glucose- and D-mannose-based antimetabolites. Part 2. Facile synthesis of 2-deoxy-2-halo-D-glucoses and -D-mannoses. Carbohydr Res. 2009 Aug 17; 344(12):1464-73. PMID: 19625015.
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    32. Gao H, Priebe W, Glod J, Banerjee D. Activation of signal transducers and activators of transcription 3 and focal adhesion kinase by stromal cell-derived factor 1 is required for migration of human mesenchymal stem cells in response to tumor cell-conditioned medium. Stem Cells. 2009 Apr; 27(4):857-65. PMID: 19350687.
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    33. Heimberger AB, Kong LY, Abou-Ghazal M, Reina-Ortiz C, Yang DS, Wei J, Qiao W, Schmittling RJ, Archer GE, Sampson JH, Hiraoka N, Priebe W, Fuller GN, Sawaya R. The role of tregs in human glioma patients and their inhibition with a novel STAT-3 inhibitor. Clin Neurosurg. 2009; 56:98-106. PMID: 20214040.
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    34. Kupferman ME, Jayakumar A, Zhou G, Xie T, Dakak-Yazici Y, Zhao M, Ju J, Mandal M, Jasser S, Madden T, Myers JN, Priebe W. Therapeutic suppression of constitutive and inducible JAK\STAT activation in head and neck squamous cell carcinoma. J Exp Ther Oncol. 2009; 8(2):117-27. PMID: 20192118.
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    35. Korchowiec J, Korchowiec B, Priebe W, Rogalska E. DFT study on the selectivity of complexation of metal cations with a dioxadithia crown ether ligand. J Phys Chem A. 2008 Dec 25; 112(51):13633-40. PMID: 19055400.
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    36. Abou-Ghazal M, Yang DS, Qiao W, Reina-Ortiz C, Wei J, Kong LY, Fuller GN, Hiraoka N, Priebe W, Sawaya R, Heimberger AB. The incidence, correlation with tumor-infiltrating inflammation, and prognosis of phosphorylated STAT3 expression in human gliomas. Clin Cancer Res. 2008 Dec 15; 14(24):8228-35. PMID: 19088040; PMCID: PMC2605668.
    37. Kong LY, Wei J, Sharma AK, Barr J, Abou-Ghazal MK, Fokt I, Weinberg J, Rao G, Grimm E, Priebe W, Heimberger AB. A novel phosphorylated STAT3 inhibitor enhances T cell cytotoxicity against melanoma through inhibition of regulatory T cells. Cancer Immunol Immunother. 2009 Jul; 58(7):1023-32. PMID: 19002459; PMCID: PMC2674523.
    38. Heimberger AB, Priebe W. Small molecular inhibitors of p-STAT3: novel agents for treatment of primary and metastatic CNS cancers. Recent Pat CNS Drug Discov. 2008 Nov; 3(3):179-88. PMID: 18991807.
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    39. Kong LY, Abou-Ghazal MK, Wei J, Chakraborty A, Sun W, Qiao W, Fuller GN, Fokt I, Grimm EA, Schmittling RJ, Archer GE, Sampson JH, Priebe W, Heimberger AB. A novel inhibitor of signal transducers and activators of transcription 3 activation is efficacious against established central nervous system melanoma and inhibits regulatory T cells. Clin Cancer Res. 2008 Sep 15; 14(18):5759-68. PMID: 18794085; PMCID: PMC2583362.
    40. van Schalkwyk DA, Priebe W, Saliba KJ. The inhibitory effect of 2-halo derivatives of D-glucose on glycolysis and on the proliferation of the human malaria parasite Plasmodium falciparum. J Pharmacol Exp Ther. 2008 Nov; 327(2):511-7. PMID: 18713952.
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    41. Corvis Y, Korchowiec B, Korchowiec J, Badis M, Mironiuk-Puchalska E, Fokt I, Priebe W, Rogalska E. Complexation of metal ions in Langmuir films formed with two amphiphilic dioxadithia crown ethers. J Phys Chem B. 2008 Sep 4; 112(35):10953-63. PMID: 18698707.
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    42. Bednarek E, Sitkowski J, Kawecki R, Kozerski L, Bocian W, Pazderski L, Priebe W. Structure and dynamics of methyl cis-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxo-hexopyranoside complexes with PtCl(2) and PdCl(2), by (1)H, (2)H, (13)C, (15)N and (195)Pt NMR spectroscopy in DMSO, CD(3)CN and H(2)O. Dalton Trans. 2008 Aug 21; (31):4129-37. PMID: 18688431.
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    43. Verstovsek S, Manshouri T, Quintás-Cardama A, Harris D, Cortes J, Giles FJ, Kantarjian H, Priebe W, Estrov Z. WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res. 2008 Feb 1; 14(3):788-96. PMID: 18245540.
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    44. Ferrajoli A, Faderl S, Van Q, Koch P, Harris D, Liu Z, Hazan-Halevy I, Wang Y, Kantarjian HM, Priebe W, Estrov Z. WP1066 disrupts Janus kinase-2 and induces caspase-dependent apoptosis in acute myelogenous leukemia cells. Cancer Res. 2007 Dec 1; 67(23):11291-9. PMID: 18056455.
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    45. Tamura A, Onishi Y, An R, Koshiba S, Wakabayashi K, Hoshijima K, Priebe W, Yoshida T, Kometani S, Matsubara T, Mikuriya K, Ishikawa T. In vitro evaluation of photosensitivity risk related to genetic polymorphisms of human ABC transporter ABCG2 and inhibition by drugs. Drug Metab Pharmacokinet. 2007 Dec; 22(6):428-40. PMID: 18159130.
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    46. Hussain SF, Kong LY, Jordan J, Conrad C, Madden T, Fokt I, Priebe W, Heimberger AB. A novel small molecule inhibitor of signal transducers and activators of transcription 3 reverses immune tolerance in malignant glioma patients. Cancer Res. 2007 Oct 15; 67(20):9630-6. PMID: 17942891.
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    47. Gruber BM, Anuszewska EL, Bubko I, Go?dzik A, Fokt I, Priebe W. Effect of structural modification at the 4, 3', and 2' positions of doxorubicin on topoisomerase II poisoning, apoptosis, and cytotoxicity in human melanoma cells. Arch Immunol Ther Exp (Warsz). 2007 May-Jun; 55(3):193-8. PMID: 17557149; PMCID: PMC2765644.
    48. Bidwell GL, Davis AN, Fokt I, Priebe W, Raucher D. A thermally targeted elastin-like polypeptide-doxorubicin conjugate overcomes drug resistance. Invest New Drugs. 2007 Aug; 25(4):313-26. PMID: 17483874.
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    49. Tabe Y, Jin L, Tsutsumi-Ishii Y, Xu Y, McQueen T, Priebe W, Mills GB, Ohsaka A, Nagaoka I, Andreeff M, Konopleva M. Activation of integrin-linked kinase is a critical prosurvival pathway induced in leukemic cells by bone marrow-derived stromal cells. Cancer Res. 2007 Jan 15; 67(2):684-94. PMID: 17234779.
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    50. Bartholomeusz GA, Talpaz M, Kapuria V, Kong LY, Wang S, Estrov Z, Priebe W, Wu J, Donato NJ. Activation of a novel Bcr/Abl destruction pathway by WP1130 induces apoptosis of chronic myelogenous leukemia cells. Blood. 2007 Apr 15; 109(8):3470-8. PMID: 17202319.
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    51. Zheng M, Priebe W, Walch ET, Roth KG, Han M, Tang CH, Lee S, Poindexter NJ, Fokt I, Grimm EA. WP760, a melanoma selective drug. Cancer Chemother Pharmacol. 2007 Oct; 60(5):625-33. PMID: 17195067.
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    52. Mansilla S, Rojas M, Bataller M, Priebe W, Portugal J. Circumvention of the multidrug-resistance protein (MRP-1) by an antitumor drug through specific inhibition of gene transcription in breast tumor cells. Biochem Pharmacol. 2007 Apr 1; 73(7):934-42. PMID: 17217917.
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    53. Bidwell GL, Fokt I, Priebe W, Raucher D. Development of elastin-like polypeptide for thermally targeted delivery of doxorubicin. Biochem Pharmacol. 2007 Mar 1; 73(5):620-31. PMID: 17161827.
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    54. Brooks TA, O'Loughlin KL, Minderman H, Bundy BN, Ford LA, Vredenburg MR, Bernacki RJ, Priebe W, Baer MR. The 4'-O-benzylated doxorubicin analog WP744 overcomes resistance mediated by P-glycoprotein, multidrug resistance protein and breast cancer resistance protein in cell lines and acute myeloid leukemia cells. Invest New Drugs. 2007 Apr; 25(2):115-22. PMID: 17072745.
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    55. Iwamaru A, Szymanski S, Iwado E, Aoki H, Yokoyama T, Fokt I, Hess K, Conrad C, Madden T, Sawaya R, Kondo S, Priebe W, Kondo Y. A novel inhibitor of the STAT3 pathway induces apoptosis in malignant glioma cells both in vitro and in vivo. Oncogene. 2007 Apr 12; 26(17):2435-44. PMID: 17043651.
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    56. Anuszewska E, Ch?opkiewicz B, Gruber B, Marczewska J, Priebe W, Skurzak H. Estimation of DNA damage and cytotoxicity of anthracycline analogs in human melanoma cells on early and late passages. Acta Pol Pharm. 2006 Jul-Aug; 63(4):321-4. PMID: 17203872.
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    57. Mansilla S, Priebe W, Portugal J. Transcriptional changes facilitate mitotic catastrophe in tumour cells that contain functional p53. Eur J Pharmacol. 2006 Jul 1; 540(1-3):34-45. PMID: 16735036.
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    58. Lampidis TJ, Kurtoglu M, Maher JC, Liu H, Krishan A, Sheft V, Szymanski S, Fokt I, Rudnicki WR, Ginalski K, Lesyng B, Priebe W. Efficacy of 2-halogen substituted D-glucose analogs in blocking glycolysis and killing "hypoxic tumor cells". Cancer Chemother Pharmacol. 2006 Dec; 58(6):725-34. PMID: 16555088.
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    59. Mansilla S, Priebe W, Portugal J. Mitotic catastrophe results in cell death by caspase-dependent and caspase-independent mechanisms. Cell Cycle. 2006 Jan; 5(1):53-60. PMID: 16319532.
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    60. Gruber BM, Anuszewska EL, Roman I, Go?dzik A, Priebe W, Fokt I. Topoisomerase II alpha expression and cytotoxicity of anthracyclines in human neoplastic cells. Acta Pol Pharm. 2006 Jan-Feb; 63(1):15-8. PMID: 17515324.
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    61. Portugal J, Cashman DJ, Trent JO, Ferrer-Miralles N, Przewloka T, Fokt I, Priebe W, Chaires JB. A new bisintercalating anthracycline with picomolar DNA binding affinity. J Med Chem. 2005 Dec 29; 48(26):8209-19. PMID: 16366602.
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    62. Faderl S, Ferrajoli A, Harris D, Van Q, Priebe W, Estrov Z. WP-1034, a novel JAK-STAT inhibitor, with proapoptotic and antileukemic activity in acute myeloid leukemia (AML). Anticancer Res. 2005 May-Jun; 25(3B):1841-50. PMID: 16158916.
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    63. Gruber BM, Anuszewska EL, Bubko I, Gozdzik A, Priebe W, Fokt I. Relationship between topoisomerase II-DNA cleavable complexes, apoptosis and cytotoxic activity of anthracyclines in human cervix carcinoma cells. Anticancer Res. 2005 May-Jun; 25(3B):2193-8. PMID: 16158963.
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    64. Maher JC, Savaraj N, Priebe W, Liu H, Lampidis TJ. Differential sensitivity to 2-deoxy-D-glucose between two pancreatic cell lines correlates with GLUT-1 expression. Pancreas. 2005 Mar; 30(2):e34-9. PMID: 15714127.
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    65. Ch?opkiewicz B, Ejchart A, Marczewska J, Anuszewska E, Priebe W. Evaluation of mutagenic and genotoxic activities of new derivatives of anthracyclines. Acta Pol Pharm. 2005 Mar-Apr; 62(2):99-104. PMID: 16161349.
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    66. Gruber BM, Anuszewska EL, Bubko I, Kasprzycka-Guttman T, Misiewicz I, Skupi?ska K, Priebe W, Fokt I. Constitutive activation of transcription factor NFkappaB as a possible marker of sensitivity of neoplastic cells to anthracyclines. Acta Pol Pharm. 2005 Jan-Feb; 62(1):17-23. PMID: 16022489.
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    67. Nair RR, Wang H, Jamaluddin MS, Fokt I, Priebe W, Boyd DD. A bisanthracycline (WP631) represses uPAR gene expression and cell migration of RKO colon cancer cells by interfering with transcription factor binding to a chromatin-accessible -148/-124 promoter region. Oncol Res. 2005; 15(5):265-79. PMID: 16261846.
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    68. Marczewska J, Anuszewska EL, Priebe W. The application of the sister chromatid exchange test for evaluation of the novel anthracycline derivatives. Part I. Acta Pol Pharm. 2004 Dec; 61 Suppl:22-4. PMID: 15909928.
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    69. Trevino AV, Woynarowska BA, Herman TS, Priebe W, Woynarowski JM. Enhanced topoisomerase II targeting by annamycin and related 4-demethoxy anthracycline analogues. Mol Cancer Ther. 2004 Nov; 3(11):1403-10. PMID: 15542779.
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    70. Inge TH, Harris NL, Wu J, Azizkhan RG, Priebe W. WP744 is a novel anthracycline with enhanced activity against neuroblastoma. J Surg Res. 2004 Oct; 121(2):187-96. PMID: 15501458.
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    71. Fox KR, Webster R, Phelps RJ, Fokt I, Priebe W. Sequence selective binding of bis-daunorubicin WP631 to DNA. Eur J Biochem. 2004 Sep; 271(17):3556-66. PMID: 15317591.
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    72. Mansilla S, Priebe W, Portugal J. Sp1-targeted inhibition of gene transcription by WP631 in transfected lymphocytes. Biochemistry. 2004 Jun 15; 43(23):7584-92. PMID: 15182200.
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    73. Kutsch O, Levy DN, Bates PJ, Decker J, Kosloff BR, Shaw GM, Priebe W, Benveniste EN. Bis-anthracycline antibiotics inhibit human immunodeficiency virus type 1 transcription. Antimicrob Agents Chemother. 2004 May; 48(5):1652-63. PMID: 15105117; PMCID: PMC400550.
    74. Pozarowski P, Huang X, Gong RW, Priebe W, Darzynkiewicz Z. Simple, semiautomatic assay of cytostatic and cytotoxic effects of antitumor drugs by laser scanning cytometry: effects of the bis-intercalator WP631 on growth and cell cycle of T-24 cells. Cytometry A. 2004 Feb; 57(2):113-9. PMID: 14750133.
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    75. Ashikawa K, Shishodia S, Fokt I, Priebe W, Aggarwal BB. Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues. Biochem Pharmacol. 2004 Jan 15; 67(2):353-64. PMID: 14698047.
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    76. Maschek G, Savaraj N, Priebe W, Braunschweiger P, Hamilton K, Tidmarsh GF, De Young LR, Lampidis TJ. 2-deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res. 2004 Jan 1; 64(1):31-4. PMID: 14729604.
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    77. Paw?owska J, Priebe W, Paine MJ, Wolf CR, Borowski E, Tarasiuk J. The ability of new sugar-modified derivatives of antitumor anthracycline, daunorubicin, to stimulate NAD(P)H oxidation in different cellular oxidoreductase systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase. Oncol Res. 2004; 14(10):469-74. PMID: 15559760.
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    78. Gruber BM, Anuszewska EL, Priebe W. The effect of new anthracycline derivatives on the induction of apoptotic processes in human neoplastic cells. Folia Histochem Cytobiol. 2004; 42(2):127-30. PMID: 15253137.
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    79. Fuks L, Samochocka K, Anulewicz-Ostrowska R, Kruszewski M, Priebe W, Lewandowski W. Structure and biological activity of cationic [PtLCl(DMSO)]NO(3).DMSO complex containing a chelated diaminosugar: methyl-3,4-diamino-2,3,4,6-tetradeoxy-alpha-L-lyxopyranoside. Eur J Med Chem. 2003 Jul-Aug; 38(7-8):775-80. PMID: 12932909.
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    81. Villamarín S, Mansilla S, Ferrer-Miralles N, Priebe W, Portugal J. A comparative analysis of the time-dependent antiproliferative effects of daunorubicin and WP631. Eur J Biochem. 2003 Feb; 270(4):764-70. PMID: 12581216.
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    82. Kruszewski M, Bouzyk E, Oldak T, Samochocka K, Fuks L, Lewandowski W, Fokt I, Priebe W. Differential toxic effect of cis-platinum(II) and palladium(II) chlorides complexed with methyl 3,4-diamine-2,3,4,6-tetradeoxy-alpha-L-lyxo-hexopyranoside in mouse lymphoma cell lines differing in DSB and NER repair ability. Teratog Carcinog Mutagen. 2003; Suppl 1:1-11. PMID: 12616592.
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    83. Liu H, Savaraj N, Priebe W, Lampidis TJ. Hypoxia increases tumor cell sensitivity to glycolytic inhibitors: a strategy for solid tumor therapy (Model C). Biochem Pharmacol. 2002 Dec 15; 64(12):1745-51. PMID: 12445863.
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    84. Inge TH, Casson LK, Priebe W, Trent JO, Georgeson KE, Miller DM, Bates PJ. Importance of Sp1 consensus motifs in the MYCN promoter. Surgery. 2002 Aug; 132(2):232-8. PMID: 12219017.
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    85. Booser DJ, Esteva FJ, Rivera E, Valero V, Esparza-Guerra L, Priebe W, Hortobagyi GN. Phase II study of liposomal annamycin in the treatment of doxorubicin-resistant breast cancer. Cancer Chemother Pharmacol. 2002 Jul; 50(1):6-8. PMID: 12111105.
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    86. Salerno M, Przewloka T, Fokt I, Priebe W, Garnier-Suillerot A. Preferential efflux by P-glycoprotein, but not MRP1, of compounds containing a free electron donor amine. Biochem Pharmacol. 2002 Apr 15; 63(8):1471-9. PMID: 11996888.
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    87. Villamarín S, Ferrer-Miralles N, Mansilla S, Priebe W, Portugal J. Induction of G(2)/M arrest and inhibition of c-myc and p53 transcription by WP631 in Jurkat T lymphocytes. Biochem Pharmacol. 2002 Apr 1; 63(7):1251-8. PMID: 11960601.
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    88. Faderl S, Estrov Z, Kantarjian HM, Harris D, Van Q, Fokt I, Przewloka T, Godlewski C, Woynarowski JM, Priebe W. WP744, a novel anthracycline with enhanced proapoptotic and antileukemic activity. Anticancer Res. 2001 Nov-Dec; 21(6A):3777-84. PMID: 11911247.
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    90. Loetchutinat C, Priebe W, Garnier-Suillerot A. Drug sequestration in cytoplasmic organelles does not contribute to the diminished sensitivity of anthracyclines in multidrug resistant K562 cells. Eur J Biochem. 2001 Aug; 268(16):4459-67. PMID: 11502206.
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    91. Liu H, Hu YP, Savaraj N, Priebe W, Lampidis TJ. Hypersensitization of tumor cells to glycolytic inhibitors. Biochemistry. 2001 May 8; 40(18):5542-7. PMID: 11331019.
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    92. Frézard F, Pereira-Maia E, Quidu P, Priebe W, Garnier-Suillerot A. P-glycoprotein preferentially effluxes anthracyclines containing free basic versus charged amine. Eur J Biochem. 2001 Mar; 268(6):1561-7. PMID: 11248673.
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    94. Priebe W, Fokt I, Przewloka T, Chaires JB, Portugal J, Trent JO. Exploiting anthracycline scaffold for designing DNA-targeting agents. Methods Enzymol. 2001; 340:529-55. PMID: 11494869.
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    97. Hu Y, Moraes CT, Savaraj N, Priebe W, Lampidis TJ. Rho(0) tumor cells: a model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs. Biochem Pharmacol. 2000 Dec 15; 60(12):1897-905. PMID: 11108806.
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    99. Qu X, Trent JO, Fokt I, Priebe W, Chaires JB. Allosteric, chiral-selective drug binding to DNA. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):12032-7. PMID: 11027298; PMCID: PMC17289.
    100. Hooijberg JH, Pinedo HM, Vrasdonk C, Priebe W, Lankelma J, Broxterman HJ. The effect of glutathione on the ATPase activity of MRP1 in its natural membranes. FEBS Lett. 2000 Mar 3; 469(1):47-51. PMID: 10708754.
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    101. Rudnicki WR, Kurzepa M, Szczepanik T, Priebe W, Lesyng B. A simple model for predicting the free energy of binding between anthracycline antibiotics and DNA. Acta Biochim Pol. 2000; 47(1):1-9. PMID: 10961673.
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    102. Booser DJ, Perez-Soler R, Cossum P, Esparza-Guerra L, Wu QP, Zou Y, Priebe W, Hortobagyi GN. Phase I study of liposomal annamycin. Cancer Chemother Pharmacol. 2000; 46(5):427-32. PMID: 11127949.
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    103. Martín B, Vaquero A, Priebe W, Portugal J. Bisanthracycline WP631 inhibits basal and Sp1-activated transcription initiation in vitro. Nucleic Acids Res. 1999 Sep 1; 27(17):3402-9. PMID: 10446226.
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    104. Marbeuf-Gueye C, Ettori D, Priebe W, Kozlowski H, Garnier-Suillerot A. Correlation between the kinetics of anthracycline uptake and the resistance factor in cancer cells expressing the multidrug resistance protein or the P-glycoprotein. Biochim Biophys Acta. 1999 Jul 8; 1450(3):374-84. PMID: 10395948.
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    105. Tarasiuk J, Tkaczyk-Gobis K, Stefañska B, Dzieduszycka M, Priebe W, Martelli S, Borowski E. The role of structural factors of anthraquinone compounds and their quinone-modified analogues in NADH dehydrogenase-catalysed oxygen radical formation. Anticancer Drug Des. 1998 Dec; 13(8):923-39. PMID: 10335267.
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    106. Priebe W, Krawczyk M, Kuo MT, Yamane Y, Savaraj N, Ishikawa T. Doxorubicin- and daunorubicin-glutathione conjugates, but not unconjugated drugs, competitively inhibit leukotriene C4 transport mediated by MRP/GS-X pump. Biochem Biophys Res Commun. 1998 Jun 29; 247(3):859-63. PMID: 9647783.
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    107. Dutta R, Gao YG, Priebe W, Wang AH. Binding of the modified daunorubicin WP401 adjacent to a T-G base pair induces the reverse Watson-Crick conformation: crystal structures of the WP401-TGGCCG and WP401-CGG[br5C]CG complexes. Nucleic Acids Res. 1998 Jun 15; 26(12):3001-5. PMID: 9611247; PMCID: PMC147649.
    108. Leng F, Priebe W, Chaires JB. Ultratight DNA binding of a new bisintercalating anthracycline antibiotic. Biochemistry. 1998 Feb 17; 37(7):1743-53. PMID: 9485299.
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    109. Marbeuf-Gueye C, Broxterman HJ, Dubru F, Priebe W, Garnier-Suillerot A. Kinetics of anthracycline efflux from multidrug resistance protein-expressing cancer cells compared with P-glycoprotein-expressing cancer cells. Mol Pharmacol. 1998 Jan; 53(1):141-7. PMID: 9443942.
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    110. Robinson H, Priebe W, Chaires JB, Wang AH. Binding of two novel bisdaunorubicins to DNA studied by NMR spectroscopy. Biochemistry. 1997 Jul 22; 36(29):8663-70. PMID: 9289011.
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    111. Hu GG, Shui X, Leng F, Priebe W, Chaires JB, Williams LD. Structure of a DNA-bisdaunomycin complex. Biochemistry. 1997 May 20; 36(20):5940-6. PMID: 9166763.
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    112. Perez-Soler R, Neamati N, Zou Y, Schneider E, Doyle LA, Andreeff M, Priebe W, Ling YH. Annamycin circumvents resistance mediated by the multidrug resistance-associated protein (MRP) in breast MCF-7 and small-cell lung UMCC-1 cancer cell lines selected for resistance to etoposide. Int J Cancer. 1997 Mar 28; 71(1):35-41. PMID: 9096663.
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    113. Lampidis TJ, Kolonias D, Podona T, Israel M, Safa AR, Lothstein L, Savaraj N, Tapiero H, Priebe W. Circumvention of P-GP MDR as a function of anthracycline lipophilicity and charge. Biochemistry. 1997 Mar 4; 36(9):2679-85. PMID: 9054575.
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    114. Chaires JB, Leng F, Przewloka T, Fokt I, Ling YH, Perez-Soler R, Priebe W. Structure-based design of a new bisintercalating anthracycline antibiotic. J Med Chem. 1997 Jan 31; 40(3):261-6. PMID: 9022792.
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    115. Gallois L, Fiallo M, Laigle A, Priebe W, Garnier-Suillerot A. The overall partitioning of anthracyclines into phosphatidyl-containing model membranes depends neither on the drug charge nor the presence of anionic phospholipids. Eur J Biochem. 1996 Nov 1; 241(3):879-87. PMID: 8944778.
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    116. Consoli U, Priebe W, Ling YH, Mahadevia R, Griffin M, Zhao S, Perez-Soler R, Andreeff M. The novel anthracycline annamycin is not affected by P-glycoprotein-related multidrug resistance: comparison with idarubicin and doxorubicin in HL-60 leukemia cell lines. Blood. 1996 Jul 15; 88(2):633-44. PMID: 8695811.
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    117. Ling YH, el-Naggar AK, Priebe W, Perez-Soler R. Cell cycle-dependent cytotoxicity, G2/M phase arrest, and disruption of p34cdc2/cyclin B1 activity induced by doxorubicin in synchronized P388 cells. Mol Pharmacol. 1996 May; 49(5):832-41. PMID: 8622633.
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    119. Jollès B, Laigle A, Priebe W, Garnier-Suillerot A. Comparison of DNA sequence selectivity of anthracycline antibiotics and their 3'-hydroxylated analogs. Chem Biol Interact. 1996 Mar 25; 100(2):165-76. PMID: 8646789.
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    120. Chaires JB, Satyanarayana S, Suh D, Fokt I, Przewloka T, Priebe W. Parsing the free energy of anthracycline antibiotic binding to DNA. Biochemistry. 1996 Feb 20; 35(7):2047-53. PMID: 8652545.
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    121. Zou Y, Priebe W, Perez-Soler R. Lyophilized preliposomal formulation of the non-cross-resistant anthracycline annamycin: effect of surfactant on liposome formation, stability and size. Cancer Chemother Pharmacol. 1996; 39(1-2):103-8. PMID: 8995506.
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    122. Zou Y, Priebe W, Stephens LC, Perez-Soler R. Preclinical toxicity of liposome-incorporated annamycin: selective bone marrow toxicity with lack of cardiotoxicity. Clin Cancer Res. 1995 Nov; 1(11):1369-74. PMID: 9815933.
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    124. Zou Y, Ling YH, Reddy S, Priebe W, Perez-Soler R. Effect of vesicle size and lipid composition on the in vivo tumor selectivity and toxicity of the non-cross-resistant anthracycline annamycin incorporated in liposomes. Int J Cancer. 1995 May 29; 61(5):666-71. PMID: 7768640.
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    125. Ling YH, Zou Y, Priebe W, Perez-Soler R. Partial circumvention of multi-drug resistance by annamycin is associated with comparable inhibition of DNA synthesis in the nuclear matrix of sensitive and resistant cells. Int J Cancer. 1995 May 4; 61(3):402-8. PMID: 7729954.
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    126. Borrel MN, Fiallo M, Priebe W, Garnier-Suillerot A. P-glycoprotein-mediated efflux of hydroxyrubicin, a neutral anthracycline derivative, in resistant K562 cells. FEBS Lett. 1994 Dec 19; 356(2-3):287-99. PMID: 7805856.
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    127. Zhao JY, Savaraj N, Song R, Priebe W, Kuo MT. Overexpression of P-glycoprotein but not its mRNA in multidrug resistant cells selected with hydroxyrubicin. Anticancer Res. 1994 Sep-Oct; 14(5A):1735-42. PMID: 7531410.
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    128. Solary E, Ling YH, Perez-Soler R, Priebe W, Pommier Y. Hydroxyrubicin, a deaminated derivative of doxorubicin, inhibits mammalian DNA topoisomerase II and partially circumvents multidrug resistance. Int J Cancer. 1994 Jul 1; 58(1):85-94. PMID: 8014019.
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    129. Zou Y, Ling YH, Van NT, Priebe W, Perez-Soler R. Antitumor activity of free and liposome-entrapped annamycin, a lipophilic anthracycline antibiotic with non-cross-resistance properties. Cancer Res. 1994 Mar 15; 54(6):1479-84. PMID: 8137251.
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    130. Perez-Soler R, Ling YH, Zou Y, Priebe W. Cellular pharmacology of the partially non-cross-resistant anthracycline annamycin entrapped in liposomes in KB and KB-V1 cells. Cancer Chemother Pharmacol. 1994; 34(2):109-18. PMID: 8194162.
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    131. Horton D, Priebe W, Sznaidman ML, Varela O. Synthesis and antitumor activity of anthracycline disaccharide glycosides containing daunosamine. J Antibiot (Tokyo). 1993 Nov; 46(11):1720-30. PMID: 8270495.
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    133. Zou Y, Hayman A, Priebe W, Perez-Soler R. Quantitative analysis of the lipophilic doxorubicin analogue annamycin in plasma and tissue samples by reversed-phase chromatography. J Pharm Sci. 1993 Nov; 82(11):1151-4. PMID: 8289131.
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    134. Ling Y, Priebe W, Perezsoler R. Intrinsic cytotoxicity and reversal of multidrug-resistance by monensin in kb parent and mdr cells. Int J Oncol. 1993 Nov; 3(5):971-7. PMID: 21573461.
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    135. Horton D, Issa M, Priebe W, Sznaidman ML. Synthesis of 3-deoxyaldulosonic acid esters by one-carbon chain extension of glycal-derived lactone precursors. Carbohydr Res. 1993 Aug 17; 246:105-18. PMID: 8370034.
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    136. Ling YH, Priebe W, Perez-Soler R. Apoptosis induced by anthracycline antibiotics in P388 parent and multidrug-resistant cells. Cancer Res. 1993 Apr 15; 53(8):1845-52. PMID: 8467504.
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    137. Ling YH, Priebe W, Yang LY, Burke TG, Pommier Y, Perez-Soler R. In vitro cytotoxicity, cellular pharmacology, and DNA lesions induced by annamycin, an anthracycline derivative with high affinity for lipid membranes. Cancer Res. 1993 Apr 1; 53(7):1583-9. PMID: 8453627.
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    138. Priebe W, Van NT, Burke TG, Perez-Soler R. Removal of the basic center from doxorubicin partially overcomes multidrug resistance and decreases cardiotoxicity. Anticancer Drugs. 1993 Feb; 4(1):37-48. PMID: 8457713.
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    139. Zou Y, Priebe W, Ling YH, Perez-Soler R. Organ distribution and tumor uptake of annamycin, a new anthracycline derivative with high affinity for lipid membranes, entrapped in multilamellar vesicles. Cancer Chemother Pharmacol. 1993; 32(3):190-6. PMID: 8500223.
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    140. Lothstein L, Hosey LM, Sweatman TW, Koseki Y, Dockter M, Priebe W. N-benzyladriamycin-14-valerate (AD 198)-resistant cells exhibit highly selective cross-resistance to other anthracyclines that circumvent multidrug resistance. Oncol Res. 1993; 5(6-7):229-34. PMID: 7907237.
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    141. Priebe W, Neamati N, Perez-soler R. 3'-Hydroxyesorubicin halogenated at C-2'. J Antibiot (Tokyo). 1992 Mar; 45(3):386-93. PMID: 1577666.
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    142. Perez-Soler R, Priebe W. Liposomal formulation and antitumor activity of 14-O-palmitoyl-hydroxyrubicin. Cancer Chemother Pharmacol. 1992; 30(4):267-71. PMID: 1643693.
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    143. Priebe WM, Senecal FM. Gastric chloroma associated with upper gastrointestinal tract bleeding. Gastrointest Endosc. 1991 Jul-Aug; 37(4):482-4. PMID: 1916176.
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    144. Horton D, Priebe W, Sznaidman M. Iodoalkoxylation of 1,5-anhydro-2-deoxy-hex-1-enitols (glycals). Carbohydr Res. 1990 Sep 19; 205:71-86. PMID: 2276153.
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    147. Horton D, Priebe W, Carter JP, Filppi J, Wolgemuth RL. 4-Demethoxy-3'-N-trifluoroacetyldoxorubicin. Synthesis and solid tumor activity. Drug Des Deliv. 1990 Jun; 6(2):123-9. PMID: 2080980.
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    148. Horton D, Priebe W, Sznaidman M. A new approach to 2-deoxyglycosides permitting access to anthracycline glycosides specifically labeled at the 2'-position. Carbohydr Res. 1989 Apr 1; 187(1):149-53. PMID: 2752389.
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    149. Horton D, Priebe W, Sznaidman M. Preparation of 4-O-acetyl-1,5-anhydro-2,3,6-trideoxy-3-trifluoroacetamido-L- lyxo-hex-1-enitol, a key intermediate in synthesis of daunosamine glycosides. Carbohydr Res. 1989 Apr 1; 187(1):145-8. PMID: 2752388.
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    150. Horton D, Priebe W, Sznaidman M. Preparative procedures for conversion of daunorubicin into doxorubicin (Adriamycin) and 14-O-acetyldoxorubicin by way of 14-bromodaunorubicin. Carbohydr Res. 1988 Dec 31; 184:231-5. PMID: 3242811.
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    151. Priebe WM. The endoscopic appearance of Burkitt's lymphoma involving the stomach and colon. Gastrointest Endosc. 1986 Oct; 32(5):352-4. PMID: 3770388.
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    152. Horton D, Priebe W, Varela O. Selective acylation of 6-deoxyglycals. Carbohydr Res. 1985 Dec 1; 144(2):317-24. PMID: 4092210.
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    153. Horton D, Priebe W, Varela O. Selective silylation of 6-deoxyglycals. Carbohydr Res. 1985 Dec 1; 144(2):325-30. PMID: 4092211.
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    154. Horton D, Priebe W, Varela O. Synthesis and antitumor activity of 2'-bromo- and 2'-chloro-3'-acetoxy-3'-deaminodaunorubicin analogs. Carbohydr Res. 1985 Dec 1; 144(2):305-15. PMID: 4092209.
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    155. Bhaté P, Horton D, Priebe W. Allylic rearrangement of 6-deoxyglycals having practical utility. Carbohydr Res. 1985 Dec 1; 144(2):331-7. PMID: 4092212.
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    156. Cheung TM, Horton D, Priebe W, Turner WR, Weckerle W. Sugar-ring analogs of daunorubicin: 3'-epidaunorubicin, 3'-hydroxy-3',5'-diepidaunorubicin and 3',6'-dihydroxy-3',5'-diepidaunorubicin. J Antibiot (Tokyo). 1985 May; 38(5):683-6. PMID: 4019314.
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    157. Horton D, Priebe W. Oxyhalogenation of glycals for the synthesis of anti-tumor-active 2'-halo daunorubicin analogs. Carbohydr Res. 1985 Feb 28; 136:391-6. PMID: 4005892.
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    158. Horton D, Priebe W, Varela O. 3'-Deamino-4'-epi-3'-hydroxy-daunorubicin and -doxorubicin. Synthesis and antitumor activity. J Antibiot (Tokyo). 1984 Dec; 37(12):1635-41. PMID: 6549317.
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    160. Priebe WM, Simon JB. Crohn's disease of the stomach with outlet obstruction: a case report and review of therapy. J Clin Gastroenterol. 1983 Oct; 5(5):441-5. PMID: 6415159.
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    162. Priebe WM, DaCosta LR, Beck IT. Is epigastric tenderness a sign of peptic ulcer disease? Gastroenterology. 1982 Jan; 82(1):16-9. PMID: 7053328.
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