NHAT TU LE

TitleAssistant Professor
InstitutionMD Anderson
DepartmentCardiology
Address2121 Holcombe Blvd
Houston TX 77030-4244
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Le NT, Sandhu UG, Quintana-Quezada RA, Hoang NM, Fujiwara K, Abe JI. Flow signaling and atherosclerosis. Cell Mol Life Sci. 2017 05; 74(10):1835-1858. PMID: 28039525.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    2. Cameron SJ, Ture SK, Mickelsen D, Chakrabarti E, Modjeski KL, McNitt S, Seaberry M, Field DJ, Le NT, Abe J, Morrell CN. Platelet Extracellular Regulated Protein Kinase 5 Is a Redox Switch and Triggers Maladaptive Platelet Responses and Myocardial Infarct Expansion. Circulation. 2015 Jul 07; 132(1):47-58. PMID: 25934838.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    3. Heo KS, Le NT, Cushman HJ, Giancursio CJ, Chang E, Woo CH, Sullivan MA, Taunton J, Yeh ET, Fujiwara K, Abe J. Disturbed flow-activated p90RSK kinase accelerates atherosclerosis by inhibiting SENP2 function. J Clin Invest. 2015 Mar 02; 125(3):1299-310. PMID: 25689261.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    4. Le NT, Takei Y, Izawa-Ishizawa Y, Heo KS, Lee H, Smrcka AV, Miller BL, Ko KA, Ture S, Morrell C, Fujiwara K, Akaike M, Abe J. Identification of activators of ERK5 transcriptional activity by high-throughput screening and the role of endothelial ERK5 in vasoprotective effects induced by statins and antimalarial agents. J Immunol. 2014 Oct 01; 193(7):3803-15. PMID: 25187658.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    5. Nguyen CT, Le NT, Tran TD, Kim EH, Park SS, Luong TT, Chung KT, Pyo S, Rhee DK. Streptococcus pneumoniae ClpL modulates adherence to A549 human lung cells through Rap1/Rac1 activation. Infect Immun. 2014 Sep; 82(9):3802-10. PMID: 24980975.
      Citations: 7     Fields:    Translation:HumansCells
    6. Heo KS, Chang E, Le NT, Cushman H, Yeh ET, Fujiwara K, Abe J. De-SUMOylation enzyme of sentrin/SUMO-specific protease 2 regulates disturbed flow-induced SUMOylation of ERK5 and p53 that leads to endothelial dysfunction and atherosclerosis. Circ Res. 2013 Mar 15; 112(6):911-23. PMID: 23381569.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    7. Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. A crucial role for p90RSK-mediated reduction of ERK5 transcriptional activity in endothelial dysfunction and atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99. PMID: 23243209.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    8. Heo KS, Chang E, Takei Y, Le NT, Woo CH, Sullivan MA, Morrell C, Fujiwara K, Abe J. Phosphorylation of protein inhibitor of activated STAT1 (PIAS1) by MAPK-activated protein kinase-2 inhibits endothelial inflammation via increasing both PIAS1 transrepression and SUMO E3 ligase activity. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):321-9. PMID: 23202365.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    9. Le NT, Corsetti JP, Dehoff-Sparks JL, Sparks CE, Fujiwara K, Abe J. Reactive Oxygen Species, SUMOylation, and Endothelial Inflammation. Int J Inflam. 2012; 2012:678190. PMID: 22991685.
      Citations:    
    10. Le NT, Takei Y, Shishido T, Woo CH, Chang E, Heo KS, Lee H, Lu Y, Morrell C, Oikawa M, McClain C, Wang X, Tournier C, Molina CA, Taunton J, Yan C, Fujiwara K, Patterson C, Yang J, Abe J. p90RSK targets the ERK5-CHIP ubiquitin E3 ligase activity in diabetic hearts and promotes cardiac apoptosis and dysfunction. Circ Res. 2012 Feb 17; 110(4):536-50. PMID: 22267842.
      Citations: 25     Fields:    Translation:AnimalsCells
    11. Heo KS, Lee H, Nigro P, Thomas T, Le NT, Chang E, McClain C, Reinhart-King CA, King MR, Berk BC, Fujiwara K, Woo CH, Abe J. PKC? mediates disturbed flow-induced endothelial apoptosis via p53 SUMOylation. J Cell Biol. 2011 May 30; 193(5):867-84. PMID: 21624955.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    12. Chang E, Heo KS, Woo CH, Lee H, Le NT, Thomas TN, Fujiwara K, Abe J. MK2 SUMOylation regulates actin filament remodeling and subsequent migration in endothelial cells by inhibiting MK2 kinase and HSP27 phosphorylation. Blood. 2011 Feb 24; 117(8):2527-37. PMID: 21131586.
      Citations: 24     Fields:    Translation:HumansCells
    13. Woo CH, Le NT, Shishido T, Chang E, Lee H, Heo KS, Mickelsen DM, Lu Y, McClain C, Spangenberg T, Yan C, Molina CA, Yang J, Patterson C, Abe J. Novel role of C terminus of Hsc70-interacting protein (CHIP) ubiquitin ligase on inhibiting cardiac apoptosis and dysfunction via regulating ERK5-mediated degradation of inducible cAMP early repressor. FASEB J. 2010 Dec; 24(12):4917-28. PMID: 20724525.
      Citations: 25     Fields:    Translation:AnimalsCells
    14. Khaibullina A, Jang BS, Sun H, Le N, Yu S, Frenkel V, Carrasquillo JA, Pastan I, Li KC, Paik CH. Pulsed high-intensity focused ultrasound enhances uptake of radiolabeled monoclonal antibody to human epidermoid tumor in nude mice. J Nucl Med. 2008 Feb; 49(2):295-302. PMID: 18199622.
      Citations: 24     Fields:    Translation:HumansAnimals
    15. Kobayashi H, Koyama Y, Barrett T, Hama Y, Regino CA, Shin IS, Jang BS, Le N, Paik CH, Choyke PL, Urano Y. Multimodal nanoprobes for radionuclide and five-color near-infrared optical lymphatic imaging. ACS Nano. 2007 Nov; 1(4):258-64. PMID: 19079788.
      Citations: 54     Fields:    Translation:HumansAnimals
    16. Jang BS, Lim E, Hee Park S, Shin IS, Danthi SN, Hwang IS, Le N, Yu S, Xie J, Li KC, Carrasquillo JA, Paik CH. Radiolabeled high affinity peptidomimetic antagonist selectively targets alpha(v)beta(3) receptor-positive tumor in mice. Nucl Med Biol. 2007 May; 34(4):363-70. PMID: 17499725.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    17. Tu le N, Jeong HY, Kwon HY, Ogunniyi AD, Paton JC, Pyo SN, Rhee DK. Modulation of adherence, invasion, and tumor necrosis factor alpha secretion during the early stages of infection by Streptococcus pneumoniae ClpL. Infect Immun. 2007 Jun; 75(6):2996-3005. PMID: 17403879.
      Citations: 14     Fields:    Translation:Cells
    18. Shin IS, Jang BS, Danthi SN, Xie J, Yu S, Le N, Maeng JS, Hwang IS, Li KC, Carrasquillo JA, Paik CH. Use of antibody as carrier of oligomers of peptidomimetic alphavbeta3 antagonist to target tumor-induced neovasculature. Bioconjug Chem. 2007 May-Jun; 18(3):821-8. PMID: 17375899.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    19. Zhang Y, Xiang L, Hassan R, Paik CH, Carrasquillo JA, Jang BS, Le N, Ho M, Pastan I. Synergistic antitumor activity of taxol and immunotoxin SS1P in tumor-bearing mice. Clin Cancer Res. 2006 Aug 01; 12(15):4695-701. PMID: 16899620.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    20. Kim I, Kobayashi H, Yoo TM, Kim MK, Le N, Han ES, Wang QC, Pastan I, Carrasquillo JA, Paik CH. Lowering of pI by acylation improves the renal uptake of 99mTc-labeled anti-Tac dsFv: effect of different acylating reagents. Nucl Med Biol. 2002 Nov; 29(8):795-801. PMID: 12453588.
      Citations: 4     Fields:    Translation:AnimalsCellsPHPublic Health
    21. Role for SUMOylation in disturbed flow-induced atherosclerotic plaque formation. Biomedical Engineering Letters. 5:162-171.
    22. Reactive oxygen species, SUMOylation, and endothelial inflammation. International Journal of Inflammation. 2012.
    23. Flow signaling and atherosclerosis. Cellular and Molecular Life Sciences. 1-24.
    24. Erratum to Modulation of adherence, invasion, and tumor necrosis factor alpha secretion during the early stages of infection by Streptococcus pneumoniae ClpL [Infection and Immunity, 75, 6 (2007) 2996-3005, 2007]. Infection and Immunity. 83:1224.
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