VALERIE LEBLEU

TitleAssistant Professor
InstitutionMD Anderson
DepartmentCancer Biology
Address1881 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. McAndrews KM, Dowlatshahi DP, Dai J, Becker LM, Hensel J, Snowden LM, Leveille JM, Brunner MR, Holden KW, Hopkins NS, Harris AM, Kumpati J, Whitt MA, Lee JJ, Ostrosky-Zeichner LL, Papanna R, LeBleu VS, Allison JP, Kalluri R. Heterogeneous antibodies against SARS-CoV-2 spike receptor binding domain and nucleocapsid with implications for COVID-19 immunity. JCI Insight. 2020 09 17; 5(18). PMID: 32796155.
      Citations: 2     Fields:    Translation:HumansCellsPHPublic Health
    2. Lovisa S, Fletcher-Sananikone E, Sugimoto H, Hensel J, Lahiri S, Hertig A, Taduri G, Lawson E, Dewar R, Revuelta I, Kato N, Wu CJ, Bassett RL, Putluri N, Zeisberg M, Zeisberg EM, LeBleu VS, Kalluri R. Endothelial-to-mesenchymal transition compromises vascular integrity to induce Myc-mediated metabolic reprogramming in kidney fibrosis. Sci Signal. 2020 Jun 09; 13(635). PMID: 32518142.
      Citations:    Fields:    
    3. Becker LM, O'Connell JT, Vo AP, Cain MP, Tampe D, Bizarro L, Sugimoto H, McGow AK, Asara JM, Lovisa S, McAndrews KM, Zielinski R, Lorenzi PL, Zeisberg M, Raza S, LeBleu VS, Kalluri R. Epigenetic Reprogramming of Cancer-Associated Fibroblasts Deregulates Glucose Metabolism and Facilitates Progression of Breast Cancer. Cell Rep. 2020 Jun 02; 31(9):107701. PMID: 32492417.
      Citations:    Fields:    
    4. LeBleu VS, Kalluri R. Exosomes as a Multicomponent Biomarker Platform in Cancer. Trends Cancer. 2020 09; 6(9):767-774. PMID: 32307267.
      Citations: 1     Fields:    
    5. LeBleu VS, Neilson EG. Origin and functional heterogeneity of fibroblasts. FASEB J. 2020 Mar; 34(3):3519-3536. PMID: 32037627.
      Citations: 2     Fields:    
    6. Kalluri R, LeBleu VS. The biology, function, and biomedical applications of exosomes. Science. 2020 02 07; 367(6478). PMID: 32029601.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    7. Helmink BA, Reddy SM, Gao J, Zhang S, Basar R, Thakur R, Yizhak K, Sade-Feldman M, Blando J, Han G, Gopalakrishnan V, Xi Y, Zhao H, Amaria RN, Tawbi HA, Cogdill AP, Liu W, LeBleu VS, Kugeratski FG, Patel S, Davies MA, Hwu P, Lee JE, Gershenwald JE, Lucci A, Arora R, Woodman S, Keung EZ, Gaudreau PO, Reuben A, Spencer CN, Burton EM, Haydu LE, Lazar AJ, Zapassodi R, Hudgens CW, Ledesma DA, Ong S, Bailey M, Warren S, Rao D, Krijgsman O, Rozeman EA, Peeper D, Blank CU, Schumacher TN, Butterfield LH, Zelazowska MA, McBride KM, Kalluri R, Allison J, Petitprez F, Fridman WH, Sautès-Fridman C, Hacohen N, Rezvani K, Sharma P, Tetzlaff MT, Wang L, Wargo JA. B cells and tertiary lymphoid structures promote immunotherapy response. Nature. 2020 01; 577(7791):549-555. PMID: 31942075.
      Citations: 47     Fields:    Translation:HumansCells
    8. Green NH, Galvan DL, Badal SS, Chang BH, LeBleu VS, Long J, Jonasch E, Danesh FR. MTHFD2 links RNA methylation to metabolic reprogramming in renal cell carcinoma. Oncogene. 2019 08; 38(34):6211-6225. PMID: 31289360.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    9. McAndrews KM, LeBleu VS, Kalluri R. SIRT1 Regulates Lysosome Function and Exosome Secretion. Dev Cell. 2019 05 06; 49(3):302-303. PMID: 31063745.
      Citations: 2     Fields:    Translation:HumansCells
    10. LeBleu VS, Kalluri R. Exosomes Exercise Inhibition of Anti-Tumor Immunity during Chemotherapy. Immunity. 2019 03 19; 50(3):547-549. PMID: 30893584.
      Citations: 4     Fields:    Translation:HumansCells
    11. Chen Y, Keskin D, Sugimoto H, Kanasaki K, Phillips PE, Bizarro L, Sharpe A, LeBleu VS, Kalluri R. Podoplanin+ tumor lymphatics are rate limiting for breast cancer metastasis. PLoS Biol. 2018 12; 16(12):e2005907. PMID: 30592710.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    12. Parchem JG, Kanasaki K, Kanasaki M, Sugimoto H, Xie L, Hamano Y, Lee SB, Gattone VH, Parry S, Strauss JF, Garovic VD, McElrath TF, Lu KH, Sibai BM, LeBleu VS, Carmeliet P, Kalluri R. Loss of placental growth factor ameliorates maternal hypertension and preeclampsia in mice. J Clin Invest. 2018 11 01; 128(11):5008-5017. PMID: 30179860.
      Citations: 2     Fields:    Translation:Animals
    13. Chen Y, LeBleu VS, Carstens JL, Sugimoto H, Zheng X, Malasi S, Saur D, Kalluri R. Dual reporter genetic mouse models of pancreatic cancer identify an epithelial-to-mesenchymal transition-independent metastasis program. EMBO Mol Med. 2018 10; 10(10). PMID: 30120146.
      Citations: 7     Fields:    Translation:Animals
    14. Becker LM, LeBleu VS. Endoglin Targeting in Colorectal Tumor Microenvironment. Clin Cancer Res. 2018 12 15; 24(24):6110-6111. PMID: 30076135.
      Citations:    Fields:    Translation:HumansCells
    15. Eikesdal HP, Becker LM, Teng Y, Kizu A, Carstens JL, Kanasaki K, Sugimoto H, LeBleu VS, Kalluri R. BMP7 Signaling in TGFBR2-Deficient Stromal Cells Provokes Epithelial Carcinogenesis. Mol Cancer Res. 2018 10; 16(10):1568-1578. PMID: 29934328.
      Citations:    Fields:    Translation:HumansAnimalsCells
    16. Mendt M, Kamerkar S, Sugimoto H, McAndrews KM, Wu CC, Gagea M, Yang S, Blanko EVR, Peng Q, Ma X, Marszalek JR, Maitra A, Yee C, Rezvani K, Shpall E, LeBleu VS, Kalluri R. Generation and testing of clinical-grade exosomes for pancreatic cancer. JCI Insight. 2018 04 19; 3(8). PMID: 29669940.
      Citations: 46     Fields:    Translation:AnimalsCells
    17. LeBleu VS, Kalluri R. A peek into cancer-associated fibroblasts: origins, functions and translational impact. Dis Model Mech. 2018 04 19; 11(4). PMID: 29686035.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    18. Kamerkar S, LeBleu VS, Sugimoto H, Yang S, Ruivo CF, Melo SA, Lee JJ, Kalluri R. Exosomes facilitate therapeutic targeting of oncogenic KRAS in pancreatic cancer. Nature. 2017 06 22; 546(7659):498-503. PMID: 28607485.
      Citations: 193     Fields:    Translation:AnimalsCells
    19. Carstens JL, Correa de Sampaio P, Yang D, Barua S, Wang H, Rao A, Allison JP, LeBleu VS, Kalluri R. Spatial computation of intratumoral T cells correlates with survival of patients with pancreatic cancer. Nat Commun. 2017 04 27; 8:15095. PMID: 28447602.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    20. Kalluri R, LeBleu VS. Discovery of Double-Stranded Genomic DNA in Circulating Exosomes. Cold Spring Harb Symp Quant Biol. 2016; 81:275-280. PMID: 28424339.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    21. Yang S, Che SP, Kurywchak P, Tavormina JL, Gansmo LB, Correa de Sampaio P, Tachezy M, Bockhorn M, Gebauer F, Haltom AR, Melo SA, LeBleu VS, Kalluri R. Detection of mutant KRAS and TP53 DNA in circulating exosomes from healthy individuals and patients with pancreatic cancer. . 2017 03 04; 18(3):158-165. PMID: 28121262.
      Citations:    
    22. Kim J, de Sampaio PC, Lundy DM, Peng Q, Evans KW, Sugimoto H, Gagea M, Kienast Y, Amaral NSD, Rocha RM, Eikesdal HP, Lønning PE, Meric-Bernstam F, LeBleu VS. Heterogeneous perivascular cell coverage affects breast cancer metastasis and response to chemotherapy. JCI Insight. 2016 Dec 22; 1(21):e90733. PMID: 28018977.
      Citations: 5     Fields:    
    23. Laklai H, Miroshnikova YA, Pickup MW, Collisson EA, Kim GE, Barrett AS, Hill RC, Lakins JN, Schlaepfer DD, Mouw JK, LeBleu VS, Roy N, Novitskiy SV, Johansen JS, Poli V, Kalluri R, Iacobuzio-Donahue CA, Wood LD, Hebrok M, Hansen K, Moses HL, Weaver VM. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nat Med. 2016 05; 22(5):497-505. PMID: 27089513.
      Citations: 118     Fields:    Translation:HumansAnimalsCells
    24. Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival. Cancer Cell. 2015 Dec 14; 28(6):831-833. PMID: 28843279.
      Citations: 28     Fields:    
    25. Cleland TP, Schroeter ER, Zamdborg L, Zheng W, Lee JE, Tran JC, Bern M, Duncan MB, Lebleu VS, Ahlf DR, Thomas PM, Kalluri R, Kelleher NL, Schweitzer MH. Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. J Proteome Res. 2015 Dec 04; 14(12):5252-62. PMID: 26595531.
      Citations: 15     Fields:    Translation:AnimalsCells
    26. Zheng X, Carstens JL, Kim J, Scheible M, Kaye J, Sugimoto H, Wu CC, LeBleu VS, Kalluri R. Epithelial-to-mesenchymal transition is dispensable for metastasis but induces chemoresistance in pancreatic cancer. Nature. 2015 Nov 26; 527(7579):525-530. PMID: 26560028.
      Citations: 542     Fields:    Translation:Animals
    27. Lovisa S, LeBleu VS, Tampe B, Sugimoto H, Vadnagara K, Carstens JL, Wu CC, Hagos Y, Burckhardt BC, Pentcheva-Hoang T, Nischal H, Allison JP, Zeisberg M, Kalluri R. Epithelial-to-mesenchymal transition induces cell cycle arrest and parenchymal damage in renal fibrosis. Nat Med. 2015 Sep; 21(9):998-1009. PMID: 26236991.
      Citations: 157     Fields:    Translation:HumansAnimalsCells
    28. Melo SA, Luecke LB, Kahlert C, Fernandez AF, Gammon ST, Kaye J, LeBleu VS, Mittendorf EA, Weitz J, Rahbari N, Reissfelder C, Pilarsky C, Fraga MF, Piwnica-Worms D, Kalluri R. Glypican-1 identifies cancer exosomes and detects early pancreatic cancer. Nature. 2015 Jul 09; 523(7559):177-82. PMID: 26106858.
      Citations: 511     Fields:    Translation:HumansAnimalsCells
    29. LeBleu VS. Imaging the Tumor Microenvironment. Cancer J. 2015 May-Jun; 21(3):174-8. PMID: 26049696.
      Citations: 6     Fields:    Translation:Humans
    30. Keskin D, Kim J, Cooke VG, Wu CC, Sugimoto H, Gu C, De Palma M, Kalluri R, LeBleu VS. Targeting vascular pericytes in hypoxic tumors increases lung metastasis via angiopoietin-2. Cell Rep. 2015 Feb 24; 10(7):1066-81. PMID: 25704811.
      Citations: 55     Fields:    Translation:AnimalsCells
    31. LeBleu VS, O'Connell JT, Gonzalez Herrera KN, Wikman H, Pantel K, Haigis MC, de Carvalho FM, Damascena A, Domingos Chinen LT, Rocha RM, Asara JM, Kalluri R. PGC-1a mediates mitochondrial biogenesis and oxidative phosphorylation in cancer cells to promote metastasis. Nat Cell Biol. 2014 Oct; 16(10):992-1003, 1-15. PMID: 25241037.
      Citations: 304     Fields:    Translation:HumansAnimalsCells
    32. Zeisberg M, Tampe B, LeBleu V, Tampe D, Zeisberg EM, Kalluri R. Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure. Am J Pathol. 2014 Oct; 184(10):2687-98. PMID: 25111226.
      Citations: 8     Fields:    Translation:Animals
    33. Özdemir BC, Pentcheva-Hoang T, Carstens JL, Zheng X, Wu CC, Simpson TR, Laklai H, Sugimoto H, Kahlert C, Novitskiy SV, De Jesus-Acosta A, Sharma P, Heidari P, Mahmood U, Chin L, Moses HL, Weaver VM, Maitra A, Allison JP, LeBleu VS, Kalluri R. Depletion of carcinoma-associated fibroblasts and fibrosis induces immunosuppression and accelerates pancreas cancer with reduced survival. Cancer Cell. 2014 Jun 16; 25(6):719-34. PMID: 24856586.
      Citations: 528     Fields:    Translation:HumansAnimalsCells
    34. Tampe B, Tampe D, Müller CA, Sugimoto H, LeBleu V, Xu X, Müller GA, Zeisberg EM, Kalluri R, Zeisberg M. Tet3-mediated hydroxymethylation of epigenetically silenced genes contributes to bone morphogenic protein 7-induced reversal of kidney fibrosis. J Am Soc Nephrol. 2014 May; 25(5):905-12. PMID: 24480825.
      Citations: 35     Fields:    Translation:AnimalsCells
    35. Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Reply to Regarding the mechanism of action of a proposed peptide agonist of the bone morphogenetic protein receptor activin-like kinase 3. Nat Med. 2013 Jul; 19(7):810-1. PMID: 23836214.
      Citations: 1     Fields:    Translation:Animals
    36. LeBleu VS, Taduri G, O'Connell J, Teng Y, Cooke VG, Woda C, Sugimoto H, Kalluri R. Origin and function of myofibroblasts in kidney fibrosis. Nat Med. 2013 Aug; 19(8):1047-53. PMID: 23817022.
      Citations: 357     Fields:    Translation:AnimalsCells
    37. LeBleu VS, Teng Y, O'Connell JT, Charytan D, Müller GA, Müller CA, Sugimoto H, Kalluri R. Identification of human epididymis protein-4 as a fibroblast-derived mediator of fibrosis. Nat Med. 2013 Feb; 19(2):227-31. PMID: 23353556.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    38. Borges FT, Melo SA, Özdemir BC, Kato N, Revuelta I, Miller CA, Gattone VH, LeBleu VS, Kalluri R. TGF-ß1-containing exosomes from injured epithelial cells activate fibroblasts to initiate tissue regenerative responses and fibrosis. J Am Soc Nephrol. 2013 Feb; 24(3):385-92. PMID: 23274427.
      Citations: 103     Fields:    Translation:HumansAnimalsCells
    39. Sugimoto H, LeBleu VS, Bosukonda D, Keck P, Taduri G, Bechtel W, Okada H, Carlson W, Bey P, Rusckowski M, Tampe B, Tampe D, Kanasaki K, Zeisberg M, Kalluri R. Activin-like kinase 3 is important for kidney regeneration and reversal of fibrosis. Nat Med. 2012 Feb 05; 18(3):396-404. PMID: 22306733.
      Citations: 77     Fields:    Translation:AnimalsCells
    40. Cooke VG, LeBleu VS, Keskin D, Khan Z, O'Connell JT, Teng Y, Duncan MB, Xie L, Maeda G, Vong S, Sugimoto H, Rocha RM, Damascena A, Brentani RR, Kalluri R. Pericyte depletion results in hypoxia-associated epithelial-to-mesenchymal transition and metastasis mediated by met signaling pathway. Cancer Cell. 2012 Jan 17; 21(1):66-81. PMID: 22264789.
      Citations: 162     Fields:    Translation:HumansAnimalsCells
    41. LeBleu VS, Kalluri R. Blockade of PDGF receptor signaling reduces myofibroblast number and attenuates renal fibrosis. Kidney Int. 2011 Dec; 80(11):1119-21. PMID: 22083636.
      Citations: 9     Fields:    Translation:AnimalsCells
    42. De Raedt T, Walton Z, Yecies JL, Li D, Chen Y, Malone CF, Maertens O, Jeong SM, Bronson RT, Lebleu V, Kalluri R, Normant E, Haigis MC, Manning BD, Wong KK, Macleod KF, Cichowski K. Exploiting cancer cell vulnerabilities to develop a combination therapy for ras-driven tumors. Cancer Cell. 2011 Sep 13; 20(3):400-13. PMID: 21907929.
      Citations: 103     Fields:    Translation:AnimalsCells
    43. O'Connell JT, Sugimoto H, Cooke VG, MacDonald BA, Mehta AI, LeBleu VS, Dewar R, Rocha RM, Brentani RR, Resnick MB, Neilson EG, Zeisberg M, Kalluri R. VEGF-A and Tenascin-C produced by S100A4+ stromal cells are important for metastatic colonization. Proc Natl Acad Sci U S A. 2011 Sep 20; 108(38):16002-7. PMID: 21911392.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    44. LeBleu V, Sund M, Sugimoto H, Birrane G, Kanasaki K, Finan E, Miller CA, Gattone VH, McLaughlin H, Shield CF, Kalluri R. Identification of the NC1 domain of {alpha}3 chain as critical for {alpha}3{alpha}4{alpha}5 type IV collagen network assembly. J Biol Chem. 2010 Dec 31; 285(53):41874-85. PMID: 20847057.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    45. LeBleu V, Sugimoto H, Mundel TM, Gerami-Naini B, Finan E, Miller CA, Gattone VH, Lu L, Shield CF, Folkman J, Kalluri R. Stem cell therapies benefit Alport syndrome. J Am Soc Nephrol. 2009 Nov; 20(11):2359-70. PMID: 19833902.
      Citations: 26     Fields:    Translation:AnimalsCells
    46. Tzur A, Kafri R, LeBleu VS, Lahav G, Kirschner MW. Cell growth and size homeostasis in proliferating animal cells. Science. 2009 Jul 10; 325(5937):167-71. PMID: 19589995.
      Citations: 126     Fields:    Translation:AnimalsCells
    47. Schweitzer MH, Zheng W, Organ CL, Avci R, Suo Z, Freimark LM, Lebleu VS, Duncan MB, Vander Heiden MG, Neveu JM, Lane WS, Cottrell JS, Horner JR, Cantley LC, Kalluri R, Asara JM. Biomolecular characterization and protein sequences of the Campanian hadrosaur B. canadensis. Science. 2009 May 01; 324(5927):626-31. PMID: 19407199.
      Citations: 46     Fields:    Translation:AnimalsCells
    48. LeBleu VS, Kalluri R. Stem cell-based therapy for glomerular diseases: an evolving concept. J Am Soc Nephrol. 2008 Sep; 19(9):1621-3. PMID: 18701605.
      Citations: 4     Fields:    Translation:Animals
    49. Lebleu VS, Sugimoto H, Miller CA, Gattone VH, Kalluri R. Lymphocytes are dispensable for glomerulonephritis but required for renal interstitial fibrosis in matrix defect-induced Alport renal disease. Lab Invest. 2008 Mar; 88(3):284-92. PMID: 18180701.
      Citations: 18     Fields:    Translation:AnimalsCells
    50. Kanasaki K, Kanda Y, Palmsten K, Tanjore H, Lee SB, Lebleu VS, Gattone VH, Kalluri R. Integrin beta1-mediated matrix assembly and signaling are critical for the normal development and function of the kidney glomerulus. Dev Biol. 2008 Jan 15; 313(2):584-93. PMID: 18082680.
      Citations: 67     Fields:    Translation:AnimalsCells
    51. LeBleu VS, Macdonald B, Kalluri R. Structure and function of basement membranes. Exp Biol Med (Maywood). 2007 Oct; 232(9):1121-9. PMID: 17895520.
      Citations: 127     Fields:    Translation:HumansAnimals
    52. Lebleu VS, Thornton M, Gonda SR, Helmstetter CE. Technology for cell cycle research with unstressed steady-state cultures. Cytotechnology. 2006 Jul; 51(3):149-57. PMID: 19002885.
      Citations: 4     Fields:    
    53. Sugimoto H, Yang C, LeBleu VS, Soubasakos MA, Giraldo M, Zeisberg M, Kalluri R. BMP-7 functions as a novel hormone to facilitate liver regeneration. FASEB J. 2007 Jan; 21(1):256-64. PMID: 17116741.
      Citations: 32     Fields:    Translation:HumansAnimals
    54. Genotype tunes pancreatic ductal adenocarcinoma tissue tension to induce matricellular fibrosis and tumor progression. Nature Medicine. 22:497-505.
    55. Mass Spectrometry and Antibody-Based Characterization of Blood Vessels from Brachylophosaurus canadensis. Journal of Proteome Research. 14:5252-5262.
    56. Erratum. Nature Cell Biology. 16:1125.
    57. Thrombospondin-1 deficiency causes a shift from fibroproliferative to inflammatory kidney disease and delays onset of renal failure. American Journal of Pathology. 184:2687-2698.
    58. Imaging the tumor microenvironment. Cancer Journal (United States). 21:174-178.
    59. Erratum to Depletion of Carcinoma-Associated Fibroblasts and Fibrosis Induces Immunosuppression and Accelerates Pancreas Cancer with Reduced Survival [Cancer Cell 25, 719-734; (2014)]. Cancer Cell. 28:831-833.
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