TitleAssociate Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPO Box 389
Smithville TX 78957-0389
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wible DJ, Parikh Z, Cho EJ, Chen MD, Mukhopadhyay S, Dalby KN, Varadarajan S, Bratton SB. Unexpected inhibition of the lipid kinase PIKfyve reveals an epistatic role for p38 MAPKs in endolysosomal fission and volume control. bioRxiv. 2023 Mar 14. PMID: 36993747; PMCID: PMC10054966.
    2. Wible DJ, Chao HP, Tang DG, Bratton SB. ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. Cell Discov. 2019; 5:42. PMID: 31636955; PMCID: PMC6796855.
      Citations: 15     
    3. Wible DJ, Bratton SB. Reciprocity in ROS and autophagic signaling. Curr Opin Toxicol. 2018 Feb; 7:28-36. PMID: 29457143; PMCID: PMC5810588.
      Citations: 15     
    4. Wu CC, Bratton SB. Caspase-9 swings both ways in the apoptosome. Mol Cell Oncol. 2017; 4(2):e1281865. PMID: 28401186; PMCID: PMC5383358.
      Citations: 6     
    5. Wu CC, Lee S, Malladi S, Chen MD, Mastrandrea NJ, Zhang Z, Bratton SB. The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nat Commun. 2016 11 24; 7:13565. PMID: 27882936; PMCID: PMC5123071.
      Citations: 28     Fields:    Translation:AnimalsCells
    6. Nowinski SM, Solmonson A, Rundhaug JE, Rho O, Cho J, Lago CU, Riley CL, Lee S, Kohno S, Dao CK, Nikawa T, Bratton SB, Wright CW, Fischer SM, DiGiovanni J, Mills EM. Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nat Commun. 2015 Aug 27; 6:8137. PMID: 26310111; PMCID: PMC4552083.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    7. Lee S, Challa-Malladi M, Bratton SB, Wright CW. Nuclear factor-?B-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1). J Biol Chem. 2014 Oct 31; 289(44):30680-30689. PMID: 25246529; PMCID: PMC4215246.
      Citations: 19     Fields:    Translation:HumansCells
    8. Richburg JH, Myers JL, Bratton SB. The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis. Semin Cell Dev Biol. 2014 Jun; 30:27-35. PMID: 24632385; PMCID: PMC4043869.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    9. Yeh TC, Bratton SB. DrICE resurrects Grim to antagonize DIAP1. Cell Cycle. 2014; 13(5):685-6. PMID: 24526123; PMCID: PMC3979898.
      Citations:    Fields:    Translation:Animals
    10. Mahajan IM, Chen MD, Muro I, Robertson JD, Wright CW, Bratton SB. BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS One. 2014; 9(1):e84388. PMID: 24427286; PMCID: PMC3888412.
      Citations: 5     Fields:    Translation:HumansCells
    11. Yeh TC, Bratton SB. Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14284-9. PMID: 23940367; PMCID: PMC3761634.
      Citations: 7     Fields:    Translation:AnimalsCells
    12. Wu CC, Bratton SB. Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal. 2013 Aug 20; 19(6):546-58. PMID: 22978471; PMCID: PMC3717204.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    13. Bratton SB. Peptide inhibitors: Four of a kind beats a pair. Nat Chem Biol. 2012 Jun 18; 8(7):606-7. PMID: 22710307; PMCID: PMC3688271.
      Citations:    Fields:    Translation:Humans
    14. Fisher AA, Labenski MT, Malladi S, Chapman JD, Bratton SB, Monks TJ, Lau SS. The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation. Toxicol Sci. 2011 Jul; 122(1):64-72. PMID: 21527774; PMCID: PMC3203403.
      Citations: 4     Fields:    Translation:AnimalsCells
    15. Wu CC, Bratton SB. DARK apoptosome secrets come to light. Structure. 2011 Jan 12; 19(1):4-6. PMID: 21220110; PMCID: PMC3688273.
      Citations: 2     Fields:    
    16. Bratton SB, Salvesen GS. Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci. 2010 Oct 01; 123(Pt 19):3209-14. PMID: 20844150; PMCID: PMC2939798.
      Citations: 159     Fields:    Translation:HumansAnimalsCells
    17. Lau SS, Kuhlman CL, Bratton SB, Monks TJ. Role of hydroquinone-thiol conjugates in benzene-mediated toxicity. Chem Biol Interact. 2010 Mar 19; 184(1-2):212-7. PMID: 20034486; PMCID: PMC2846198.
      Citations: 6     Fields:    Translation:AnimalsCells
    18. Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB. The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 2009 Jul 08; 28(13):1916-25. PMID: 19494828; PMCID: PMC2711187.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    19. Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB. The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem. 2009 May 08; 284(19):12772-82. PMID: 19258326; PMCID: PMC2676007.
      Citations: 81     Fields:    Translation:HumansCells
    20. Fisher AA, Labenski MT, Malladi S, Gokhale V, Bowen ME, Milleron RS, Bratton SB, Monks TJ, Lau SS. Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c. Biochemistry. 2007 Oct 02; 46(39):11090-100. PMID: 17824617.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    21. Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 2007 Jul 11; 26(13):3144-56. PMID: 17557079; PMCID: PMC1914093.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    22. Yin W, Mendenhall JM, Bratton SB, Oung T, Janssen WG, Morrison JH, Gore AC. Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals. Exp Biol Med (Maywood). 2007 May; 232(5):662-73. PMID: 17463163.
      Citations: 15     Fields:    Translation:Animals
    23. Chandra D, Bratton SB, Person MD, Tian Y, Martin AG, Ayres M, Fearnhead HO, Gandhi V, Tang DG. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell. 2006 Jun 30; 125(7):1333-46. PMID: 16814719.
      Citations: 55     Fields:    Translation:HumansCells
    24. Milleron RS, Bratton SB. Heat shock induces apoptosis independently of any known initiator caspase-activating complex. J Biol Chem. 2006 Jun 23; 281(25):16991-17000. PMID: 16618700.
      Citations: 26     Fields:    Translation:HumansCells
    25. Mufti AR, Burstein E, Csomos RA, Graf PC, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS. XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. Mol Cell. 2006 Mar 17; 21(6):775-85. PMID: 16543147.
      Citations: 62     Fields:    Translation:HumansCells
    26. Lewis J, Burstein E, Reffey SB, Bratton SB, Roberts AB, Duckett CS. Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. J Biol Chem. 2004 Mar 05; 279(10):9023-9. PMID: 14701799.
      Citations: 42     Fields:    Translation:HumansCells
    27. MacFarlane M, Merrison W, Bratton SB, Cohen GM. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem. 2002 Sep 27; 277(39):36611-6. PMID: 12121969.
      Citations: 82     Fields:    Translation:HumansCells
    28. Cain K, Bratton SB, Cohen GM. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie. 2002 Feb-Mar; 84(2-3):203-14. PMID: 12022951.
      Citations: 94     Fields:    Translation:HumansAnimalsCells
    29. Sun XM, Bratton SB, Butterworth M, MacFarlane M, Cohen GM. Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem. 2002 Mar 29; 277(13):11345-51. PMID: 11801595.
      Citations: 49     Fields:    Translation:HumansCells
    30. The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nature Communications. 7.
    31. Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nature Communications. 6.
    32. Does ATP promote or protect cells from apoptosis?. Cancer Biology and Therapy. 5:712.
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