TitleAssociate Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPO Box 389
Smithville TX 78957-0389
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wible DJ, Chao HP, Tang DG, Bratton SB. ATG5 cancer mutations and alternative mRNA splicing reveal a conjugation switch that regulates ATG12-ATG5-ATG16L1 complex assembly and autophagy. Cell Discov. 2019; 5:42. PMID: 31636955.
      Citations: 13     
    2. Wible DJ, Bratton SB. Reciprocity in ROS and autophagic signaling. Curr Opin Toxicol. 2018 Feb; 7:28-36. PMID: 29457143.
      Citations: 13     
    3. Wu CC, Bratton SB. Caspase-9 swings both ways in the apoptosome. Mol Cell Oncol. 2017; 4(2):e1281865. PMID: 28401186.
      Citations: 6     
    4. Wu CC, Lee S, Malladi S, Chen MD, Mastrandrea NJ, Zhang Z, Bratton SB. The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nat Commun. 2016 11 24; 7:13565. PMID: 27882936.
      Citations: 28     Fields:    Translation:AnimalsCells
    5. Nowinski SM, Solmonson A, Rundhaug JE, Rho O, Cho J, Lago CU, Riley CL, Lee S, Kohno S, Dao CK, Nikawa T, Bratton SB, Wright CW, Fischer SM, DiGiovanni J, Mills EM. Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nat Commun. 2015 Aug 27; 6:8137. PMID: 26310111.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    6. Lee S, Challa-Malladi M, Bratton SB, Wright CW. Nuclear factor-?B-inducing kinase (NIK) contains an amino-terminal inhibitor of apoptosis (IAP)-binding motif (IBM) that potentiates NIK degradation by cellular IAP1 (c-IAP1). J Biol Chem. 2014 Oct 31; 289(44):30680-30689. PMID: 25246529.
      Citations: 17     Fields:    Translation:HumansCells
    7. Richburg JH, Myers JL, Bratton SB. The role of E3 ligases in the ubiquitin-dependent regulation of spermatogenesis. Semin Cell Dev Biol. 2014 Jun; 30:27-35. PMID: 24632385.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    8. Yeh TC, Bratton SB. DrICE resurrects Grim to antagonize DIAP1. Cell Cycle. 2014; 13(5):685-6. PMID: 24526123.
      Citations:    Fields:    Translation:Animals
    9. Mahajan IM, Chen MD, Muro I, Robertson JD, Wright CW, Bratton SB. BH3-only protein BIM mediates heat shock-induced apoptosis. PLoS One. 2014; 9(1):e84388. PMID: 24427286.
      Citations: 5     Fields:    Translation:HumansCells
    10. Yeh TC, Bratton SB. Caspase-dependent regulation of the ubiquitin-proteasome system through direct substrate targeting. Proc Natl Acad Sci U S A. 2013 Aug 27; 110(35):14284-9. PMID: 23940367.
      Citations: 7     Fields:    Translation:AnimalsCells
    11. Wu CC, Bratton SB. Regulation of the intrinsic apoptosis pathway by reactive oxygen species. Antioxid Redox Signal. 2013 Aug 20; 19(6):546-58. PMID: 22978471.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    12. Bratton SB. Peptide inhibitors: Four of a kind beats a pair. Nat Chem Biol. 2012 Jun 18; 8(7):606-7. PMID: 22710307.
      Citations:    Fields:    Translation:Humans
    13. Lago CU, Nowinski SM, Rundhaug JE, Pfeiffer ME, Kiguchi K, Hirasaka K, Yang X, Abramson EM, Bratton SB, Rho O, Colavitti R, Kenaston MA, Nikawa T, Trempus C, Digiovanni J, Fischer SM, Mills EM. Mitochondrial respiratory uncoupling promotes keratinocyte differentiation and blocks skin carcinogenesis. Oncogene. 2012 Nov 01; 31(44):4725-31. PMID: 22266853.
      Citations: 11     Fields:    Translation:AnimalsCells
    14. Fisher AA, Labenski MT, Malladi S, Chapman JD, Bratton SB, Monks TJ, Lau SS. The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation. Toxicol Sci. 2011 Jul; 122(1):64-72. PMID: 21527774.
      Citations: 4     Fields:    Translation:AnimalsCells
    15. Wu CC, Bratton SB. DARK apoptosome secrets come to light. Structure. 2011 Jan 12; 19(1):4-6. PMID: 21220110.
      Citations: 2     Fields:    
    16. Bratton SB, Salvesen GS. Regulation of the Apaf-1-caspase-9 apoptosome. J Cell Sci. 2010 Oct 01; 123(Pt 19):3209-14. PMID: 20844150.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    17. Son JK, Varadarajan S, Bratton SB. TRAIL-activated stress kinases suppress apoptosis through transcriptional upregulation of MCL-1. Cell Death Differ. 2010 Aug; 17(8):1288-301. PMID: 20168333.
      Citations: 19     Fields:    Translation:HumansCells
    18. Lau SS, Kuhlman CL, Bratton SB, Monks TJ. Role of hydroquinone-thiol conjugates in benzene-mediated toxicity. Chem Biol Interact. 2010 Mar 19; 184(1-2):212-7. PMID: 20034486.
      Citations: 6     Fields:    Translation:AnimalsCells
    19. Malladi S, Challa-Malladi M, Fearnhead HO, Bratton SB. The Apaf-1*procaspase-9 apoptosome complex functions as a proteolytic-based molecular timer. EMBO J. 2009 Jul 08; 28(13):1916-25. PMID: 19494828.
      Citations: 66     Fields:    Translation:HumansAnimalsCells
    20. Choi YE, Butterworth M, Malladi S, Duckett CS, Cohen GM, Bratton SB. The E3 ubiquitin ligase cIAP1 binds and ubiquitinates caspase-3 and -7 via unique mechanisms at distinct steps in their processing. J Biol Chem. 2009 May 08; 284(19):12772-82. PMID: 19258326.
      Citations: 79     Fields:    Translation:HumansCells
    21. Fisher AA, Labenski MT, Malladi S, Gokhale V, Bowen ME, Milleron RS, Bratton SB, Monks TJ, Lau SS. Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c. Biochemistry. 2007 Oct 02; 46(39):11090-100. PMID: 17824617.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    22. Milleron RS, Bratton SB. 'Heated' debates in apoptosis. Cell Mol Life Sci. 2007 Sep; 64(18):2329-33. PMID: 17572850.
      Citations: 20     Fields:    Translation:Humans
    23. Challa M, Malladi S, Pellock BJ, Dresnek D, Varadarajan S, Yin YW, White K, Bratton SB. Drosophila Omi, a mitochondrial-localized IAP antagonist and proapoptotic serine protease. EMBO J. 2007 Jul 11; 26(13):3144-56. PMID: 17557079.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    24. Yin W, Mendenhall JM, Bratton SB, Oung T, Janssen WG, Morrison JH, Gore AC. Novel localization of NMDA receptors within neuroendocrine gonadotropin-releasing hormone terminals. Exp Biol Med (Maywood). 2007 May; 232(5):662-73. PMID: 17463163.
      Citations: 15     Fields:    Translation:Animals
    25. Chandra D, Bratton SB, Person MD, Tian Y, Martin AG, Ayres M, Fearnhead HO, Gandhi V, Tang DG. Intracellular nucleotides act as critical prosurvival factors by binding to cytochrome C and inhibiting apoptosome. Cell. 2006 Jun 30; 125(7):1333-46. PMID: 16814719.
      Citations: 55     Fields:    Translation:HumansCells
    26. Milleron RS, Bratton SB. Heat shock induces apoptosis independently of any known initiator caspase-activating complex. J Biol Chem. 2006 Jun 23; 281(25):16991-17000. PMID: 16618700.
      Citations: 25     Fields:    Translation:HumansCells
    27. Mufti AR, Burstein E, Csomos RA, Graf PC, Wilkinson JC, Dick RD, Challa M, Son JK, Bratton SB, Su GL, Brewer GJ, Jakob U, Duckett CS. XIAP Is a copper binding protein deregulated in Wilson's disease and other copper toxicosis disorders. Mol Cell. 2006 Mar 17; 21(6):775-85. PMID: 16543147.
      Citations: 60     Fields:    Translation:HumansCells
    28. Lewis J, Burstein E, Reffey SB, Bratton SB, Roberts AB, Duckett CS. Uncoupling of the signaling and caspase-inhibitory properties of X-linked inhibitor of apoptosis. J Biol Chem. 2004 Mar 05; 279(10):9023-9. PMID: 14701799.
      Citations: 42     Fields:    Translation:HumansCells
    29. Bratton SB, Cohen GM. Death receptors leave a caspase footprint that Smacs of XIAP. Cell Death Differ. 2003 Jan; 10(1):4-6. PMID: 12655287.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    30. Bratton SB, Lewis J, Butterworth M, Duckett CS, Cohen GM. XIAP inhibition of caspase-3 preserves its association with the Apaf-1 apoptosome and prevents CD95- and Bax-induced apoptosis. Cell Death Differ. 2002 Sep; 9(9):881-92. PMID: 12181739.
      Citations: 44     Fields:    Translation:HumansCells
    31. MacFarlane M, Merrison W, Bratton SB, Cohen GM. Proteasome-mediated degradation of Smac during apoptosis: XIAP promotes Smac ubiquitination in vitro. J Biol Chem. 2002 Sep 27; 277(39):36611-6. PMID: 12121969.
      Citations: 81     Fields:    Translation:HumansCells
    32. Cain K, Bratton SB, Cohen GM. The Apaf-1 apoptosome: a large caspase-activating complex. Biochimie. 2002 Feb-Mar; 84(2-3):203-14. PMID: 12022951.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    33. Sun XM, Bratton SB, Butterworth M, MacFarlane M, Cohen GM. Bcl-2 and Bcl-xL inhibit CD95-mediated apoptosis by preventing mitochondrial release of Smac/DIABLO and subsequent inactivation of X-linked inhibitor-of-apoptosis protein. J Biol Chem. 2002 Mar 29; 277(13):11345-51. PMID: 11801595.
      Citations: 51     Fields:    Translation:HumansCells
    34. Bratton SB, Cohen GM. Apoptotic death sensor: an organelle's alter ego? Trends Pharmacol Sci. 2001 Jun; 22(6):306-15. PMID: 11395159.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    35. Bratton SB, Walker G, Roberts DL, Cain K, Cohen GM. Caspase-3 cleaves Apaf-1 into an approximately 30 kDa fragment that associates with an inappropriately oligomerized and biologically inactive approximately 1.4 MDa apoptosome complex. Cell Death Differ. 2001 Apr; 8(4):425-33. PMID: 11550094.
      Citations: 13     Fields:    Translation:HumansCells
    36. Bratton SB, Walker G, Srinivasula SM, Sun XM, Butterworth M, Alnemri ES, Cohen GM. Recruitment, activation and retention of caspases-9 and -3 by Apaf-1 apoptosome and associated XIAP complexes. EMBO J. 2001 Mar 01; 20(5):998-1009. PMID: 11230124.
      Citations: 107     Fields:    Translation:HumansCells
    37. Bratton SB, Cohen GM. Caspase cascades in chemically-induced apoptosis. Adv Exp Med Biol. 2001; 500:407-20. PMID: 11764974.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    38. Bratton SB, Lau SS, Monks TJ. The putative benzene metabolite 2,3, 5-tris(glutathion-S-yl)hydroquinone depletes glutathione, stimulates sphingomyelin turnover, and induces apoptosis in HL-60 cells. Chem Res Toxicol. 2000 Jul; 13(7):550-6. PMID: 10898586.
      Citations: 3     Fields:    Translation:HumansCells
    39. Bratton SB, MacFarlane M, Cain K, Cohen GM. Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res. 2000 Apr 10; 256(1):27-33. PMID: 10739648.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    40. Cain K, Bratton SB, Langlais C, Walker G, Brown DG, Sun XM, Cohen GM. Apaf-1 oligomerizes into biologically active approximately 700-kDa and inactive approximately 1.4-MDa apoptosome complexes. J Biol Chem. 2000 Mar 03; 275(9):6067-70. PMID: 10692394.
      Citations: 82     Fields:    Translation:HumansCells
    41. Bratton SB, Lau SS, Monks TJ. Identification of quinol thioethers in bone marrow of hydroquinone/phenol-treated rats and mice and their potential role in benzene-mediated hematotoxicity. Chem Res Toxicol. 1997 Aug; 10(8):859-65. PMID: 9282834.
      Citations: 7     Fields:    Translation:AnimalsCells
    42. The Apaf-1 apoptosome induces formation of caspase-9 homo- and heterodimers with distinct activities. Nature Communications. 7.
    43. Mitochondrial uncoupling links lipid catabolism to Akt inhibition and resistance to tumorigenesis. Nature Communications. 6.
    44. Does ATP promote or protect cells from apoptosis?. Cancer Biology and Therapy. 5:712.
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