TitleAssociate Professor
InstitutionMD Anderson
DepartmentEpigenetics & Molecular Carcinogenesis
AddressPO Box 389
Smithville TX 78957-0389
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen T, Dent SY. Chromatin modifiers and remodellers: regulators of cellular differentiation. Nat Rev Genet. 2014 Feb; 15(2):93-106. PMID: 24366184; PMCID: PMC3999985.
      Citations: 257     Fields:    Translation:HumansAnimalsCells
    2. Kim SJ, Zhao H, Hardikar S, Singh AK, Goodell MA, Chen T. A DNMT3A mutation common in AML exhibits dominant-negative effects in murine ES cells. Blood. 2013 Dec 12; 122(25):4086-9. PMID: 24167195; PMCID: PMC3952368.
      Citations: 90     Fields:    Translation:AnimalsCells
    3. Zhao H, Chen T. Tet family of 5-methylcytosine dioxygenases in mammalian development. J Hum Genet. 2013 Jul; 58(7):421-7. PMID: 23719188; PMCID: PMC3977598.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    4. Nicholson TB, Singh AK, Su H, Hevi S, Wang J, Bajko J, Li M, Valdez R, Goetschkes M, Capodieci P, Loureiro J, Cheng X, Li E, Kinzel B, Labow M, Chen T. A hypomorphic lsd1 allele results in heart development defects in mice. PLoS One. 2013; 8(4):e60913. PMID: 23637775; PMCID: PMC3634827.
      Citations: 7     Fields:    Translation:AnimalsCells
    5. Moussette S, Chan D, Trasler J, Chen T, Rozen R, Naumova AK, Saferali A. DNA methyltransferase 1 (Dnmt1) mutation affects Snrpn imprinting in the mouse male germ line. Genome. 2012 Sep; 55(9):673-82. PMID: 22967183.
      Citations: 2     Fields:    Translation:AnimalsCells
    6. Stadtfeld M, Apostolou E, Ferrari F, Choi J, Walsh RM, Chen T, Ooi SS, Kim SY, Bestor TH, Shioda T, Park PJ, Hochedlinger K. Ascorbic acid prevents loss of Dlk1-Dio3 imprinting and facilitates generation of all-iPS cell mice from terminally differentiated B cells. Nat Genet. 2012 Mar 04; 44(4):398-405, S1-2. PMID: 22387999; PMCID: PMC3538378.
      Citations: 144     Fields:    Translation:AnimalsCells
    7. Xu Y, Wu F, Tan L, Kong L, Xiong L, Deng J, Barbera AJ, Zheng L, Zhang H, Huang S, Min J, Nicholson T, Chen T, Xu G, Shi Y, Zhang K, Shi YG. Genome-wide regulation of 5hmC, 5mC, and gene expression by Tet1 hydroxylase in mouse embryonic stem cells. Mol Cell. 2011 May 20; 42(4):451-64. PMID: 21514197; PMCID: PMC3099128.
      Citations: 313     Fields:    Translation:AnimalsCells
    8. He XJ, Chen T, Zhu JK. Regulation and function of DNA methylation in plants and animals. Cell Res. 2011 Mar; 21(3):442-65. PMID: 21321601; PMCID: PMC3152208.
      Citations: 182     Fields:    Translation:AnimalsCells
    9. Nguyen AT, Xiao B, Neppl RL, Kallin EM, Li J, Chen T, Wang DZ, Xiao X, Zhang Y. DOT1L regulates dystrophin expression and is critical for cardiac function. Genes Dev. 2011 Feb 01; 25(3):263-74. PMID: 21289070; PMCID: PMC3034901.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    10. Chen T. Mechanistic and functional links between histone methylation and DNA methylation. Prog Mol Biol Transl Sci. 2011; 101:335-48. PMID: 21507357.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    11. Cho HS, Suzuki T, Dohmae N, Hayami S, Unoki M, Yoshimatsu M, Toyokawa G, Takawa M, Chen T, Kurash JK, Field HI, Ponder BA, Nakamura Y, Hamamoto R. Demethylation of RB regulator MYPT1 by histone demethylase LSD1 promotes cell cycle progression in cancer cells. Cancer Res. 2011 Feb 01; 71(3):655-60. PMID: 21115810.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    12. Singh P, Han L, Rivas GE, Lee DH, Nicholson TB, Larson GP, Chen T, Szab? PE. Allele-specific H3K79 Di- versus trimethylation distinguishes opposite parental alleles at imprinted regions. Mol Cell Biol. 2010 Jun; 30(11):2693-707. PMID: 20351169; PMCID: PMC2876510.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    13. Lohmann F, Loureiro J, Su H, Fang Q, Lei H, Lewis T, Yang Y, Labow M, Li E, Chen T, Kadam S. KMT1E mediated H3K9 methylation is required for the maintenance of embryonic stem cells by repressing trophectoderm differentiation. Stem Cells. 2010 Feb; 28(2):201-12. PMID: 20014010.
      Citations: 42     Fields:    Translation:AnimalsCells
    14. Ciccone DN, Su H, Hevi S, Lei H, Bajko J, Xu G, Li E, Chen T, Gay F. KDM1B is a histone H3K4 demethylase required to establish maternal genomic imprints. Nature. 2009 Sep 17; 461(7262):415-8. PMID: 19727073.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    15. Nicholson TB, Chen T, Richard S. The physiological and pathophysiological role of PRMT1-mediated protein arginine methylation. Pharmacol Res. 2009 Dec; 60(6):466-74. PMID: 19643181.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    16. Ciccone DN, Chen T. Histone lysine methylation in genomic imprinting. Epigenetics. 2009 May 16; 4(4):216-20. PMID: 19483465.
      Citations: 4     Fields:    Translation:AnimalsCells
    17. Nicholson TB, Chen T. LSD1 demethylates histone and non-histone proteins. Epigenetics. 2009 Apr 01; 4(3):129-32. PMID: 19395867.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    18. Chen T, Li E, Yu Z, H?bert J, Richard S. A mouse PRMT1 null allele defines an essential role for arginine methylation in genome maintenance and cell proliferation. Mol Cell Biol. 2009 Jun; 29(11):2982-96. PMID: 19289494; PMCID: PMC2681996.
      Citations: 91     Fields:    Translation:AnimalsCells
    19. Wang J, Hevi S, Kurash JK, Lei H, Bajko J, Su H, Sun W, Chang H, Xu G, Li E, Chen T, Gay F, Gaudet F. The lysine demethylase LSD1 (KDM1) is required for maintenance of global DNA methylation. Nat Genet. 2009 Jan; 41(1):125-9. PMID: 19098913.
      Citations: 356     Fields:    Translation:AnimalsCells
    20. Jones B, Su H, Bhat A, Lei H, Bajko J, Hevi S, Baltus GA, Kadam S, Zhai H, Valdez R, Gonzalo S, Zhang Y, Li E, Chen T. The histone H3K79 methyltransferase Dot1L is essential for mammalian development and heterochromatin structure. PLoS Genet. 2008 Sep 12; 4(9):e1000190. PMID: 18787701; PMCID: PMC2527135.
      Citations: 169     Fields:    Translation:AnimalsCells
    21. Hu YG, Hirasawa R, Hu JL, Hata K, Li CL, Jin Y, Chen T, Li E, Rigolet M, Sasaki H, Xu GL, Viegas-P?quignot E. Regulation of DNA methylation activity through Dnmt3L promoter methylation by Dnmt3 enzymes in embryonic development. Hum Mol Genet. 2008 Sep 01; 17(17):2654-64. PMID: 18544626.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    22. Schmid RS, Tsujimoto N, Qu Q, Lei H, Li E, Chen T, Blaustein CS. A methyl-CpG-binding protein 2-enhanced green fluorescent protein reporter mouse model provides a new tool for studying the neuronal basis of Rett syndrome. Neuroreport. 2008 Mar 05; 19(4):393-8. PMID: 18287934.
      Citations: 13     Fields:    Translation:Animals
    23. Gonzalo S, Jaco I, Gonzalez S, Schoeftner S, Murchison E, Andl T, Chen T, Klatt P, Li E, Serrano M, Millar S, Hannon G, Blasco MA, Benetti R, Mu?oz P. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases. Nat Struct Mol Biol. 2008 Mar; 15(3):268-79. PMID: 18311151; PMCID: PMC2990406.
      Citations: 142     Fields:    Translation:AnimalsCells
    24. Li JY, Pu MT, Hirasawa R, Li BZ, Huang YN, Zeng R, Jing NH, Chen T, Li E, Sasaki H, Xu GL. Synergistic function of DNA methyltransferases Dnmt3a and Dnmt3b in the methylation of Oct4 and Nanog. Mol Cell Biol. 2007 Dec; 27(24):8748-59. PMID: 17938196; PMCID: PMC2169413.
      Citations: 113     Fields:    Translation:AnimalsCells
    25. Chen T, Hevi S, Tsujimoto N, He T, Zhang B, Ueda Y, Li E, Gay F. Complete inactivation of DNMT1 leads to mitotic catastrophe in human cancer cells. Nat Genet. 2007 Mar; 39(3):391-6. PMID: 17322882.
      Citations: 136     Fields:    Translation:HumansCells
    26. Gonzalo S, Jaco I, Fraga MF, Chen T, Li E, Esteller M, Blasco MA. DNA methyltransferases control telomere length and telomere recombination in mammalian cells. Nat Cell Biol. 2006 Apr; 8(4):416-24. PMID: 16565708.
      Citations: 229     Fields:    Translation:AnimalsCells
    27. Ueda Y, Okano M, Williams C, Chen T, Georgopoulos K, Li E. Roles for Dnmt3b in mammalian development: a mouse model for the ICF syndrome. Development. 2006 Mar; 133(6):1183-92. PMID: 16501171.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    28. Zhu H, Geiman TM, Xi S, Jiang Q, Schmidtmann A, Chen T, Li E, Muegge K. Lsh is involved in de novo methylation of DNA. EMBO J. 2006 Jan 25; 25(2):335-45. PMID: 16395332; PMCID: PMC1383509.
      Citations: 81     Fields:    Translation:AnimalsCells
    29. Chen T, Li E. Establishment and maintenance of DNA methylation patterns in mammals. Curr Top Microbiol Immunol. 2006; 301:179-201. PMID: 16570848.
      Citations: 58     Fields:    Translation:HumansAnimalsCells
    30. Torabi N, Franco GV, Tremblay GA, Chen T, Vogel G, Forget-Richard A, Komarova S, Tremblay ML, Li W, Li A, Gao YJ, Henderson JE, Richard S, Morel M, Cl?roux P. Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genet. 2005 Dec; 1(6):e74. PMID: 16362077; PMCID: PMC1315279.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    31. Dodge JE, Okano M, Dick F, Tsujimoto N, Chen T, Wang S, Ueda Y, Dyson N, Li E. Inactivation of Dnmt3b in mouse embryonic fibroblasts results in DNA hypomethylation, chromosomal instability, and spontaneous immortalization. J Biol Chem. 2005 May 06; 280(18):17986-91. PMID: 15757890.
      Citations: 104     Fields:    Translation:AnimalsCells
    32. Fang J, Chen T, Chadwick B, Li E, Zhang Y. Ring1b-mediated H2A ubiquitination associates with inactive X chromosomes and is involved in initiation of X inactivation. J Biol Chem. 2004 Dec 17; 279(51):52812-5. PMID: 15509584.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    33. Chen T, Tsujimoto N, Li E. The PWWP domain of Dnmt3a and Dnmt3b is required for directing DNA methylation to the major satellite repeats at pericentric heterochromatin. Mol Cell Biol. 2004 Oct; 24(20):9048-58. PMID: 15456878; PMCID: PMC517890.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    34. Chen T, Li E. Structure and function of eukaryotic DNA methyltransferases. Curr Top Dev Biol. 2004; 60:55-89. PMID: 15094296.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    35. Chen T, Ueda Y, Dodge JE, Wang Z, Li E. Establishment and maintenance of genomic methylation patterns in mouse embryonic stem cells by Dnmt3a and Dnmt3b. Mol Cell Biol. 2003 Aug; 23(16):5594-605. PMID: 12897133; PMCID: PMC166327.
      Citations: 306     Fields:    Translation:AnimalsCells
    36. Lehnertz B, Ueda Y, Derijck AA, Braunschweig U, Perez-Burgos L, Kubicek S, Chen T, Li E, Jenuwein T, Peters AH. Suv39h-mediated histone H3 lysine 9 methylation directs DNA methylation to major satellite repeats at pericentric heterochromatin. Curr Biol. 2003 Jul 15; 13(14):1192-200. PMID: 12867029.
      Citations: 538     Fields:    Translation:HumansAnimalsCells
    37. Pilotte J, Chen T, Cloutier F, Massie B, Pedraza L, Lasko P, Almazan G, Larocque D, Couture R, Richard S. Nuclear retention of MBP mRNAs in the quaking viable mice. Neuron. 2002 Dec 05; 36(5):815-29. PMID: 12467586.
      Citations: 73     Fields:    Translation:HumansAnimalsCells
    38. Chen T, Ueda Y, Xie S, Li E. A novel Dnmt3a isoform produced from an alternative promoter localizes to euchromatin and its expression correlates with active de novo methylation. J Biol Chem. 2002 Oct 11; 277(41):38746-54. PMID: 12138111.
      Citations: 156     Fields:    Translation:HumansAnimalsCells
    39. Chen T, Carvajal HV, Richard S, C?t? J. Identification of Sam68 arginine glycine-rich sequences capable of conferring nonspecific RNA binding to the GSG domain. J Biol Chem. 2001 Aug 17; 276(33):30803-11. PMID: 11395494.
      Citations: 9     Fields:    Translation:Cells
    40. Boisvert FM, Bazett-Jones DP, Richard S, Chen T. A role for the GSG domain in localizing Sam68 to novel nuclear structures in cancer cell lines. Mol Biol Cell. 1999 Sep; 10(9):3015-33. PMID: 10473643; PMCID: PMC25546.
      Citations: 67     Fields:    Translation:HumansAnimalsCells
    41. Chen T, Richard S, Di Fruscio M. Characterization of Sam68-like mammalian proteins SLM-1 and SLM-2: SLM-1 is a Src substrate during mitosis. Proc Natl Acad Sci U S A. 1999 Mar 16; 96(6):2710-5. PMID: 10077576; PMCID: PMC15834.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    42. Levy D, He B, Stregger S, Chen T, Richard S, Henderson JE, Aarts MM. Parathyroid hormone-related protein interacts with RNA. J Biol Chem. 1999 Feb 19; 274(8):4832-8. PMID: 9988723.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    43. Di Fruscio M, Chen T, Bonyadi S, Lasko P, Richard S. The identification of two Drosophila K homology domain proteins. Kep1 and SAM are members of the Sam68 family of GSG domain proteins. J Biol Chem. 1998 Nov 13; 273(46):30122-30. PMID: 9804767.
      Citations: 22     Fields:    Translation:AnimalsCells
    44. Richard S, Chen T. Structure-function analysis of Qk1: a lethal point mutation in mouse quaking prevents homodimerization. Mol Cell Biol. 1998 Aug; 18(8):4863-71. PMID: 9671495; PMCID: PMC109071.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    45. Chen T, Damaj BB, Herrera C, Lasko P, Richard S. Self-association of the single-KH-domain family members Sam68, GRP33, GLD-1, and Qk1: role of the KH domain. Mol Cell Biol. 1997 Oct; 17(10):5707-18. PMID: 9315629; PMCID: PMC232419.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    46. Chen T, Rael ED. Purification of M5, a fibrinolytic proteinase from Crotalus molossus molossus venom that attacks complement. Int J Biochem Cell Biol. 1997 May; 29(5):789-99. PMID: 9251246.
      Citations: 8     Fields:    Translation:HumansAnimals
    47. Rael ED, Rivas JZ, Chen T, Maddux N, Huizar E, Lieb CS. Differences in fibrinolysis and complement inactivation by venom from different northern blacktailed rattlesnakes (Crotalus molossus molossus). Toxicon. 1997 Apr; 35(4):505-13. PMID: 9133705.
      Citations: 7     Fields:    Translation:HumansAnimals
    48. Dynamic changes in histone modifications precede de novo DNA methylation in oocytes. Genes and Development. 29:2449-2462.
    49. Writers, Readers, and Erasers of Epigenetic Marks. 31-66.
    50. Erratum. Nature Genetics. 44:831.
    51. Retraction. Cell Research.
    52. Genetic studies on mammalian DNA methyltransferases. Advances in Experimental Medicine and Biology. 945:123-150.
    53. Maternal Setdb1 Is Required for Meiotic Progression and Preimplantation Development in Mouse. PLoS Genetics. 12.
    54. Histone Demethylase LSD1 Promotes Adipocyte Differentiation through Repressing Wnt Signaling. Cell Chemical Biology. 23:1228-1240.
    55. LSD1 is essential for oocyte meiotic progression by regulating CDC25B expression in mice. Nature Communications. 6.
    56. Ablation of the Sam68 RNA binding protein protects mice from age-related bone loss. PLoS Genetics. 1:676-688.
    57. A mammalian microRNA cluster controls DNA methylation and telomere recombination via Rbl2-dependent regulation of DNA methyltransferases (Nature Structural and Molecular Biology (2008) 15, (268-279)). Nature Structural and Molecular Biology. 15:998.
    58. SETDB1 modulates PRC2 activity at developmental genes independently of H3K9 trimethylation in mouse ES cells. Genome Research. 25:1325-1335.
    59. Defective heart development in hypomorphic LSD1 mice. Cell Research.
    60. PRMT7 Preserves Satellite Cell Regenerative Capacity. Cell Reports. 14:1528-1539.
    61. Erratum. Nature Communications. 7.
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