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QIANG SHEN

TitleAssistant Professor
InstitutionMD Anderson
DepartmentClinical Cancer Prevention
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Li D, Wang H, Ding Y, Zhang Z, Zheng Z, Dong J, Kim H, Meng X, Zhou Q, Zhou J, Fang L, Shen Q. Targeting the NRF-2/RHOA/ROCK signaling pathway with a novel aziridonin, YD0514, to suppress breast cancer progression and lung metastasis. Cancer Lett. 2018 06 28; 424:97-108. PMID: 29580806.
      View in: PubMed
    2. Zhang Z, Zheng Z, Cai J, Liu Q, Yang J, Gong Y, Wu M, Shen Q, Xu S. Effect of cadmium on oxidative stress and immune function of common carp (Cyprinus carpio L.) by transcriptome analysis. Aquat Toxicol. 2017 Nov; 192:171-177. PMID: 28963925.
      View in: PubMed
    3. Zhang Z, Liu Q, Cai J, Yang J, Shen Q, Xu S. Chlorpyrifos exposure in common carp (Cyprinus carpio L.) leads to oxidative stress and immune responses. Fish Shellfish Immunol. 2017 Aug; 67:604-611. PMID: 28648885.
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    4. Yin Y, Shen Q, Zhang P, Tao R, Chang W, Li R, Xie G, Liu W, Zhang L, Kapoor P, Song S, Ajani J, Mills GB, Chen J, Tao K, Peng G. Chk1 inhibition potentiates the therapeutic efficacy of PARP inhibitor BMN673 in gastric cancer. Am J Cancer Res. 2017; 7(3):473-483. PMID: 28401005.
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    5. Wang T, Chang C, Gu C, Tang S, Xie Q, Shen QH. An E3 Ligase Affects the NLR Receptor Stability and Immunity to Powdery Mildew. Plant Physiol. 2016 12; 172(4):2504-2515. PMID: 27780896.
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    6. Sun SS, Zhou X, Huang YY, Kong LP, Mei M, Guo WY, Zhao MH, Ren Y, Shen Q, Zhang L. Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma. Mol Cancer. 2015 Dec 21; 14:213. PMID: 26690371.
      View in: PubMed
    7. Jiang Z, Watts LT, Huang S, Shen Q, Rodriguez P, Chen C, Zhou C, Duong TQ. The Effects of Methylene Blue on Autophagy and Apoptosis in MRI-Defined Normal Tissue, Ischemic Penumbra and Ischemic Core. PLoS One. 2015; 10(6):e0131929. PMID: 26121129.
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    8. Shen Q, Ouyang J, Tang G, Jabbour EJ, Garcia-Manero G, Routbort M, Konoplev S, Bueso-Ramos C, Medeiros LJ, Jorgensen JL, Wang SA. Flow cytometry immunophenotypic findings in chronic myelomonocytic leukemia and its utility in monitoring treatment response. Eur J Haematol. 2015 Aug; 95(2):168-76. PMID: 25354960.
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    9. Shen Q, Sahin AA, Hess KR, Suki D, Aldape KD, Sawaya R, Ibrahim NK. Breast cancer with brain metastases: clinicopathologic features, survival, and paired biomarker analysis. Oncologist. 2015 May; 20(5):466-73. PMID: 25802405.
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    10. Li Y, Shen Q, Huang S, Li W, Muir ER, Long JA, Duong TQ. Cerebral angiography, blood flow and vascular reactivity in progressive hypertension. Neuroimage. 2015 May 01; 111:329-37. PMID: 25731987.
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    11. Talley Watts L, Long JA, Manga VH, Huang S, Shen Q, Duong TQ. Normobaric oxygen worsens outcome after a moderate traumatic brain injury. J Cereb Blood Flow Metab. 2015 Jul; 35(7):1137-44. PMID: 25690469.
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    12. Tang S, Wang X, Shen Q, Yang X, Yu C, Cai C, Cai G, Meng X, Zou F. Mitochondrial Ca²? uniporter is critical for store-operated Ca²? entry-dependent breast cancer cell migration. Biochem Biophys Res Commun. 2015 Feb 27; 458(1):186-93. PMID: 25640838.
      View in: PubMed
    13. Shen Q, Huang S, Duong TQ. Ultra-high spatial resolution basal and evoked cerebral blood flow MRI of the rat brain. Brain Res. 2015 Mar 02; 1599:126-36. PMID: 25557404.
      View in: PubMed
    14. Ouyang J, Zheng W, Shen Q, Goswami M, Jorgensen JL, Medeiros LJ, Wang SA. Flow cytometry immunophenotypic analysis of Philadelphia-negative myeloproliferative neoplasms: Correlation with histopathologic features. Cytometry B Clin Cytom. 2015 Jul-Aug; 88(4):236-43. PMID: 25557358.
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    15. Liu J, Cheng X, Liu D, Xu W, Wise R, Shen QH. The miR9863 family regulates distinct Mla alleles in barley to attenuate NLR receptor-triggered disease resistance and cell-death signaling. PLoS Genet. 2014 Dec; 10(12):e1004755. PMID: 25502438.
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    16. Li W, Long JA, Watts LT, Jiang Z, Shen Q, Li Y, Duong TQ. A quantitative MRI method for imaging blood-brain barrier leakage in experimental traumatic brain injury. PLoS One. 2014; 9(12):e114173. PMID: 25478693.
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    17. Ding C, Wang L, Chen H, Wild C, Ye N, Ding Y, Wang T, White MA, Shen Q, Zhou J. ent-Kaurane-based regio- and stereoselective inverse electron demand hetero-Diels-Alder reactions: synthesis of dihydropyran-fused diterpenoids. Org Biomol Chem. 2014 Nov 14; 12(42):8442-52. PMID: 25225052.
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    18. Li M, Ma X, Chiang YH, Yadeta KA, Ding P, Dong L, Zhao Y, Li X, Yu Y, Zhang L, Shen QH, Xia B, Coaker G, Liu D, Zhou JM. Proline isomerization of the immune receptor-interacting protein RIN4 by a cyclophilin inhibits effector-triggered immunity in Arabidopsis. Cell Host Microbe. 2014 Oct 08; 16(4):473-83. PMID: 25299333.
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    19. Ye N, Ding Y, Wild C, Shen Q, Zhou J. Small molecule inhibitors targeting activator protein 1 (AP-1). J Med Chem. 2014 Aug 28; 57(16):6930-48. PMID: 24831826.
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    20. Chen H, Yang Z, Ding C, Xiong A, Wild C, Wang L, Ye N, Cai G, Flores RM, Ding Y, Shen Q, Zhou J. Discovery of potent anticancer agent HJC0416, an orally bioavailable small molecule inhibitor of signal transducer and activator of transcription 3 (STAT3). Eur J Med Chem. 2014 Jul 23; 82:195-203. PMID: 24904966.
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    21. Xiong A, Yang Z, Shen Y, Zhou J, Shen Q. Transcription Factor STAT3 as a Novel Molecular Target for Cancer Prevention. Cancers (Basel). 2014 Apr 16; 6(2):926-57. PMID: 24743778.
      View in: PubMed
    22. Zhou Q, Facciponte J, Jin M, Shen Q, Lin Q. Humanized NOD-SCID IL2rg–/– mice as a preclinical model for cancer research and its potential use for individualized cancer therapies. Cancer Lett. 2014 Mar 01; 344(1):13-19. PMID: 24513265.
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    23. Kong J, Kong F, Gao J, Zhang Q, Dong S, Gu F, Ke S, Pan B, Shen Q, Sun H, Zheng L, Sun W. YC-1 enhances the anti-tumor activity of sorafenib through inhibition of signal transducer and activator of transcription 3 (STAT3) in hepatocellular carcinoma. Mol Cancer. 2014 Jan 13; 13:7. PMID: 24418169.
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    24. Tu H, Sun H, Lin Y, Ding J, Nan K, Li Z, Shen Q, Wei Y. Oxidative stress upregulates PDCD4 expression in patients with gastric cancer via miR-21. Curr Pharm Des. 2014; 20(11):1917-23. PMID: 23888942.
      View in: PubMed
    25. Shen Q, Du F, Huang S, Rodriguez P, Watts LT, Duong TQ. Neuroprotective efficacy of methylene blue in ischemic stroke: an MRI study. PLoS One. 2013; 8(11):e79833. PMID: 24278191.
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    26. Ding C, Zhang Y, Chen H, Yang Z, Wild C, Ye N, Ester CD, Xiong A, White MA, Shen Q, Zhou J. Oridonin ring A-based diverse constructions of enone functionality: identification of novel dienone analogues effective for highly aggressive breast cancer by inducing apoptosis. J Med Chem. 2013 Nov 14; 56(21):8814-25. PMID: 24128046.
      View in: PubMed
    27. Chang C, Zhang L, Shen QH. Partitioning, repressing and derepressing: dynamic regulations in MLA immune receptor triggered defense signaling. Front Plant Sci. 2013 Oct 08; 4:396. PMID: 24115952.
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    28. Shen Q, He B, Lu N, Conradt B, Grant BD, Zhou Z. Phagocytic receptor signaling regulates clathrin and epsin-mediated cytoskeletal remodeling during apoptotic cell engulfment in C. elegans. Development. 2013 Aug; 140(15):3230-43. PMID: 23861060.
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    29. Zheng X, Li A, Zhao L, Zhou T, Shen Q, Cui Q, Qin X. Key role of microRNA-15a in the KLF4 suppressions of proliferation and angiogenesis in endothelial and vascular smooth muscle cells. Biochem Biophys Res Commun. 2013 Aug 09; 437(4):625-31. PMID: 23867820.
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    30. Ding C, Zhang Y, Chen H, Wild C, Wang T, White MA, Shen Q, Zhou J. Overcoming synthetic challenges of oridonin A-ring structural diversification: regio- and stereoselective installation of azides and 1,2,3-triazoles at the C-1, C-2, or C-3 position. Org Lett. 2013 Jul 19; 15(14):3718-21. PMID: 23834026.
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    31. Ding C, Zhang Y, Chen H, Yang Z, Wild C, Chu L, Liu H, Shen Q, Zhou J. Novel nitrogen-enriched oridonin analogues with thiazole-fused A-ring: protecting group-free synthesis, enhanced anticancer profile, and improved aqueous solubility. J Med Chem. 2013 Jun 27; 56(12):5048-58. PMID: 23746196.
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    32. Zhou F, Shen Q, Claret FX. Novel roles of reactive oxygen species in the pathogenesis of acute myeloid leukemia. J Leukoc Biol. 2013 Sep; 94(3):423-9. PMID: 23715741.
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    33. Chang C, Yu D, Jiao J, Jing S, Schulze-Lefert P, Shen QH. Barley MLA immune receptors directly interfere with antagonistically acting transcription factors to initiate disease resistance signaling. Plant Cell. 2013 Mar; 25(3):1158-73. PMID: 23532068.
      View in: PubMed
    34. Chen H, Yang Z, Ding C, Chu L, Zhang Y, Terry K, Liu H, Shen Q, Zhou J. Fragment-based drug design and identification of HJC0123, a novel orally bioavailable STAT3 inhibitor for cancer therapy. Eur J Med Chem. 2013 Apr; 62:498-507. PMID: 23416191.
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    35. Meng X, Cai C, Wu J, Cai S, Ye C, Chen H, Yang Z, Zeng H, Shen Q, Zou F. TRPM7 mediates breast cancer cell migration and invasion through the MAPK pathway. Cancer Lett. 2013 Jun 01; 333(1):96-102. PMID: 23353055.
      View in: PubMed
    36. Bai S, Liu J, Chang C, Zhang L, Maekawa T, Wang Q, Xiao W, Liu Y, Chai J, Takken FL, Schulze-Lefert P, Shen QH. Structure-function analysis of barley NLR immune receptor MLA10 reveals its cell compartment specific activity in cell death and disease resistance. PLoS Pathog. 2012; 8(6):e1002752. PMID: 22685408.
      View in: PubMed
    37. Desai V, Shen Q, Duong TQ. Incorporating ADC temporal profiles to predict ischemic tissue fate in acute stroke. Brain Res. 2012 Jun 06; 1458:86-92. PMID: 22554478.
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    38. Lu N, Shen Q, Mahoney TR, Neukomm LJ, Wang Y, Zhou Z. Two PI 3-kinases and one PI 3-phosphatase together establish the cyclic waves of phagosomal PtdIns(3)P critical for the degradation of apoptotic cells. PLoS Biol. 2012 Jan; 10(1):e1001245. PMID: 22272187.
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    39. Shen Q, Huang S, Du F, Duong TQ. Probing ischemic tissue fate with BOLD fMRI of brief oxygen challenge. Brain Res. 2011 Nov 24; 1425:132-41. PMID: 22032876.
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    40. Wang GF, Wei X, Fan R, Zhou H, Wang X, Yu C, Dong L, Dong Z, Wang X, Kang Z, Ling H, Shen QH, Wang D, Zhang X. Molecular analysis of common wheat genes encoding three types of cytosolic heat shock protein 90 (Hsp90): functional involvement of cytosolic Hsp90s in the control of wheat seedling growth and disease resistance. New Phytol. 2011 Jul; 191(2):418-31. PMID: 21488877.
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    41. Maekawa T, Cheng W, Spiridon LN, Töller A, Lukasik E, Saijo Y, Liu P, Shen QH, Micluta MA, Somssich IE, Takken FLW, Petrescu AJ, Chai J, Schulze-Lefert P. Coiled-coil domain-dependent homodimerization of intracellular barley immune receptors defines a minimal functional module for triggering cell death. Cell Host Microbe. 2011 Mar 17; 9(3):187-199. PMID: 21402358.
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    42. Lu N, Shen Q, Mahoney TR, Liu X, Zhou Z. Three sorting nexins drive the degradation of apoptotic cells in response to PtdIns(3)P signaling. Mol Biol Cell. 2011 Feb 01; 22(3):354-74. PMID: 21148288.
      View in: PubMed
    43. Li Y, Shen Q, Kim HT, Bissonnette RP, Lamph WW, Yan B, Brown PH. The rexinoid bexarotene represses cyclin D1 transcription by inducing the DEC2 transcriptional repressor. Breast Cancer Res Treat. 2011 Aug; 128(3):667-77. PMID: 20821348.
      View in: PubMed
    44. Shen Q, Lee ES, Pitts RL, Wu MH, Yuan SY. Tissue inhibitor of metalloproteinase-2 regulates matrix metalloproteinase-2-mediated endothelial barrier dysfunction and breast cancer cell transmigration through lung microvascular endothelial cells. Mol Cancer Res. 2010 Jul; 8(7):939-51. PMID: 20571065.
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    45. Cai LS, Zhang JX, Shen Q, Situ HL, Song GH, Xie YC. [Features of preoperative contrast-enhanced ultrasound of breast cancer: relationship with the syndrome classification in traditional Chinese medicine]. Nan Fang Yi Ke Da Xue Xue Bao. 2010 Jun; 30(6):1404-6. PMID: 20584690.
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    46. Shen Q, Rigor RR, Pivetti CD, Wu MH, Yuan SY. Myosin light chain kinase in microvascular endothelial barrier function. Cardiovasc Res. 2010 Jul 15; 87(2):272-80. PMID: 20479130.
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    47. Chen HJ, Liu Y, Wang LN, Shen Q, Li J, Nan FJ. Discovery and structural optimization of pyrazole derivatives as novel inhibitors of Cdc25B. Bioorg Med Chem Lett. 2010 May 01; 20(9):2876-9. PMID: 20363629.
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    48. Xiao H, Ma X, Feng W, Fu Y, Lu Z, Xu M, Shen Q, Zhu Y, Zhang Y. Metformin attenuates cardiac fibrosis by inhibiting the TGFbeta1-Smad3 signalling pathway. Cardiovasc Res. 2010 Aug 01; 87(3):504-13. PMID: 20200042.
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    49. Strecker TE, Shen Q, Zhang Y, Hill JL, Li Y, Wang C, Kim HT, Gilmer TM, Sexton KR, Hilsenbeck SG, Osborne CK, Brown PH. Effect of lapatinib on the development of estrogen receptor-negative mammary tumors in mice. J Natl Cancer Inst. 2009 Jan 21; 101(2):107-13. PMID: 19141783.
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    50. Guo M, Daines D, Tang J, Shen Q, Perrin RM, Takada Y, Yuan SY, Wu MH. Fibrinogen-gamma C-terminal fragments induce endothelial barrier dysfunction and microvascular leak via integrin-mediated and RhoA-dependent mechanism. Arterioscler Thromb Vasc Biol. 2009 Mar; 29(3):394-400. PMID: 19122172.
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    51. Uray IP, Shen Q, Seo HS, Kim H, Lamph WW, Bissonnette RP, Brown PH. Rexinoid-induced expression of IGFBP-6 requires RARbeta-dependent permissive cooperation of retinoid receptors and AP-1. J Biol Chem. 2009 Jan 02; 284(1):345-53. PMID: 18957410.
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    52. Feng X, Wang LN, Zhou YY, Yu HP, Shen Q, Zang Y, Zhou YB, Li JY, Zhang HX, Li J. Discovery and characterization of a novel inhibitor of CDC25B, LGH00045. Acta Pharmacol Sin. 2008 Oct; 29(10):1268-74. PMID: 18817634.
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    53. Zhang YN, Zhang W, Hong D, Shi L, Shen Q, Li JY, Li J, Hu LH. Oleanolic acid and its derivatives: new inhibitor of protein tyrosine phosphatase 1B with cellular activities. Bioorg Med Chem. 2008 Sep 15; 16(18):8697-705. PMID: 18707891.
      View in: PubMed
    54. Shen Q, Rahn JJ, Zhang J, Gunasekera N, Sun X, Shaw AR, Hendzel MJ, Hoffman P, Bernier A, Hugh JC. MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1. Mol Cancer Res. 2008 Apr; 6(4):555-67. PMID: 18403635.
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    55. Shen Q, Uray IP, Li Y, Zhang Y, Hill J, Xu XC, Young MR, Gunther EJ, Hilsenbeck SG, Colburn NH, Chodosh LA, Brown PH. Targeting the activator protein 1 transcription factor for the prevention of estrogen receptor-negative mammary tumors. Cancer Prev Res (Phila). 2008 Jun; 1(1):45-55. PMID: 19138935.
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    56. Li Y, Zhang Y, Hill J, Kim HT, Shen Q, Bissonnette RP, Lamph WW, Brown PH. The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice. Br J Cancer. 2008 Apr 22; 98(8):1380-8. PMID: 18362934.
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    57. Shi L, Yu HP, Zhou YY, Du JQ, Shen Q, Li JY, Li J. Discovery of a novel competitive inhibitor of PTP1B by high-throughput screening. Acta Pharmacol Sin. 2008 Feb; 29(2):278-84. PMID: 18215359.
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    58. Li Y, Zhang Y, Hill J, Shen Q, Kim HT, Xu X, Hilsenbeck SG, Bissonnette RP, Lamph WW, Brown PH. The Rexinoid LG100268 prevents the development of preinvasive and invasive estrogen receptor negative tumors in MMTV-erbB2 mice. Clin Cancer Res. 2007 Oct 15; 13(20):6224-31. PMID: 17947490.
      View in: PubMed
    59. Shen QH, Schulze-Lefert P. Rumble in the nuclear jungle: compartmentalization, trafficking, and nuclear action of plant immune receptors. EMBO J. 2007 Oct 17; 26(20):4293-301. PMID: 17853890.
      View in: PubMed
    60. Shen Q, Uray IP, Li Y, Krisko TI, Strecker TE, Kim HT, Brown PH. The AP-1 transcription factor regulates breast cancer cell growth via cyclins and E2F factors. Oncogene. 2008 Jan 10; 27(3):366-77. PMID: 17637753.
      View in: PubMed
    61. Shen QH, Saijo Y, Mauch S, Biskup C, Bieri S, Keller B, Seki H, Ulker B, Somssich IE, Schulze-Lefert P. Nuclear activity of MLA immune receptors links isolate-specific and basal disease-resistance responses. Science. 2007 Feb 23; 315(5815):1098-103. PMID: 17185563.
      View in: PubMed
    62. Shen Q, Zhang Y, Uray IP, Hill JL, Kim HT, Lu C, Young MR, Gunther EJ, Hilsenbeck SG, Chodosh LA, Colburn NH, Brown PH. The AP-1 transcription factor regulates postnatal mammary gland development. Dev Biol. 2006 Jul 15; 295(2):589-603. PMID: 16678816.
      View in: PubMed
    63. Lu C, Shen Q, DuPré E, Kim H, Hilsenbeck S, Brown PH. cFos is critical for MCF-7 breast cancer cell growth. Oncogene. 2005 Sep 29; 24(43):6516-24. PMID: 16027729.
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    64. Shen Q, Brown PH. Transgenic mouse models for the prevention of breast cancer. Mutat Res. 2005 Aug 25; 576(1-2):93-110. PMID: 15888345.
      View in: PubMed
    65. Tang HW, Bian JC, Jiang F, Shen Q, Zhu QX, Zhang HW, Wu Y. [Single nucleotide polymorphisms and point mutations of ataxia telangiectasia mutated gene in Chinese of Han ethnicity]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2004 Dec; 21(6):579-82. PMID: 15583986.
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    66. Bieri S, Mauch S, Shen QH, Peart J, Devoto A, Casais C, Ceron F, Schulze S, Steinbiss HH, Shirasu K, Schulze-Lefert P. RAR1 positively controls steady state levels of barley MLA resistance proteins and enables sufficient MLA6 accumulation for effective resistance. Plant Cell. 2004 Dec; 16(12):3480-95. PMID: 15548741.
      View in: PubMed
    67. Liu Y, Lu C, Shen Q, Munoz-Medellin D, Kim H, Brown PH. AP-1 blockade in breast cancer cells causes cell cycle arrest by suppressing G1 cyclin expression and reducing cyclin-dependent kinase activity. Oncogene. 2004 Oct 28; 23(50):8238-46. PMID: 15378019.
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    68. Shen Q, Singh P. Identification of a novel SP3 binding site in the promoter of human IGFBP4 gene: role of SP3 and AP-1 in regulating promoter activity in CaCo2 cells. Oncogene. 2004 Apr 01; 23(14):2454-64. PMID: 14767471.
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    69. Lu C, Speers C, Zhang Y, Xu X, Hill J, Steinbis E, Celestino J, Shen Q, Kim H, Hilsenbeck S, Mohsin SK, Wakeling A, Osborne CK, Brown PH. Effect of epidermal growth factor receptor inhibitor on development of estrogen receptor-negative mammary tumors. J Natl Cancer Inst. 2003 Dec 17; 95(24):1825-33. PMID: 14679152.
      View in: PubMed
    70. Luo QL, Li JY, Liu ZY, Chen LL, Li J, Qian Z, Shen Q, Li Y, Lushington GH, Ye QZ, Nan FJ. Discovery and structural modification of inhibitors of methionine aminopeptidases from Escherichia coli and Saccharomyces cerevisiae. J Med Chem. 2003 Jun 19; 46(13):2631-40. PMID: 12801227.
      View in: PubMed
    71. Shen QH, Zhou F, Bieri S, Haizel T, Shirasu K, Schulze-Lefert P. Recognition specificity and RAR1/SGT1 dependence in barley Mla disease resistance genes to the powdery mildew fungus. Plant Cell. 2003 Mar; 15(3):732-44. PMID: 12615945.
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    72. Shen Q, Brown PH. Novel agents for the prevention of breast cancer: targeting transcription factors and signal transduction pathways. J Mammary Gland Biol Neoplasia. 2003 Jan; 8(1):45-73. PMID: 14587863.
      View in: PubMed
    73. Fan X, Croll RP, Wu B, Fang L, Shen Q, Painter SD, Nagle GT. Molecular cloning of a cDNA encoding the neuropeptides APGWamide and cerebral peptide 1: localization of APGWamide-like immunoreactivity in the central nervous system and male reproductive organs of Aplysia. J Comp Neurol. 1997 Oct 13; 387(1):53-62. PMID: 9331171.
      View in: PubMed
    74. Bmi1 inhibition enhances the sensitivity of pancreatic cancer cells to gemcitabine. Oncotarget. 7:37192-37204.
    75. Gemcitabine treatment promotes pancreatic cancer stemness through the Nox/ROS/NF-κB/STAT3 signaling cascade. Cancer Letters. 382:53-63.
    76. Downregulation of ACE2/Ang-(1-7)/Mas axis promotes breast cancer metastasis by enhancing store-operated calcium entry. Cancer Letters. 376:268-277.
    77. Traditional Chinese medicine targeting apoptotic mechanisms for esophageal cancer therapy. Acta Pharmacologica Sinica. 37:295-302.
    78. Targeting STAT3/miR-21 axis inhibits epithelial-mesenchymal transition via regulating CDK5 in head and neck squamous cell carcinoma. Molecular Cancer. 14.
    79. Small molecule inhibitors targeting activator protein 1 (AP-1). Journal of Medicinal Chemistry. 57:6930-6948.
    80. Discovery and development of natural product oridonin-inspired anticancer agents. European Journal of Medicinal Chemistry. 122:102-117.
    81. Qigesan inhibits migration and invasion of esophageal cancer cells via inducing connexin expression and enhancing gap junction function. Cancer Letters. 380:184-190.
    82. AP-1 blockade in vivo suppresses development of mammary tumor im MMTV- erbB2 mice. Cancer Epidemiology, Biomarkers and Prevention. 14.
    83. Transcription factor STAT3 as a novel molecular target for cancer prevention. Cancers. 6:926-957.
    84. Discovery of O-alkylamino-tethered niclosamide derivatives as potent and orally bioavailable anticancer agents. ACS Medicinal Chemistry Letters. 4:180-185.
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