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TODD M LINK

TitleAssistant Professor
InstitutionMD Anderson
DepartmentGenomic Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Pisaneschi F, Lin YH, Leonard PG, Satani N, Yan VC, Hammoudi N, Raghavan S, Link TM, K Georgiou D, Czako B, Muller FL. The 3S Enantiomer Drives Enolase Inhibitory Activity in SF2312 and Its Analogues. Molecules. 2019 Jul 09; 24(13). PMID: 31324042.
      View in: PubMed
    2. Chan WK, Horvath TD, Tan L, Link T, Harutyunyan KG, Pontikos MA, Anishkin A, Du D, Martin LA, Yin E, Rempe SB, Sukharev S, Konopleva M, Weinstein JN, Lorenzi PL. Glutaminase Activity of L-Asparaginase Contributes to Durable Preclinical Activity against Acute Lymphoblastic Leukemia. Mol Cancer Ther. 2019 09; 18(9):1587-1592. PMID: 31209181.
      View in: PubMed
    3. Ishizawa J, Zarabi SF, Davis RE, Halgas O, Nii T, Jitkova Y, Zhao R, St-Germain J, Heese LE, Egan G, Ruvolo VR, Barghout SH, Nishida Y, Hurren R, Ma W, Gronda M, Link T, Wong K, Mabanglo M, Kojima K, Borthakur G, MacLean N, Ma MCJ, Leber AB, Minden MD, Houry W, Kantarjian H, Stogniew M, Raught B, Pai EF, Schimmer AD, Andreeff M. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality. Cancer Cell. 2019 05 13; 35(5):721-737.e9. PMID: 31056398.
      View in: PubMed
    4. Leonard PG, Satani N, Maxwell D, Lin YH, Hammoudi N, Peng Z, Pisaneschi F, Link TM, Lee GR, Sun D, Prasad BAB, Di Francesco ME, Czako B, Asara JM, Wang YA, Bornmann W, DePinho RA, Muller FL. SF2312 is a natural phosphonate inhibitor of enolase. Nat Chem Biol. 2016 Dec; 12(12):1053-1058. PMID: 27723749.
      View in: PubMed
    5. Campbell JC, Kim JJ, Li KY, Huang GY, Reger AS, Matsuda S, Sankaran B, Link TM, Yuasa K, Ladbury JE, Casteel DE, Kim C. Structural Basis of Cyclic Nucleotide Selectivity in cGMP-dependent Protein Kinase II. J Biol Chem. 2016 Mar 11; 291(11):5623-33. PMID: 26769964.
      View in: PubMed
    6. Mandal PK, Morlacchi P, Knight JM, Link TM, Lee GR, Nurieva R, Singh D, Dhanik A, Kavraki L, Corry DB, Ladbury JE, McMurray JS. Targeting the Src Homology 2 (SH2) Domain of Signal Transducer and Activator of Transcription 6 (STAT6) with Cell-Permeable, Phosphatase-Stable Phosphopeptide Mimics Potently Inhibits Tyr641 Phosphorylation and Transcriptional Activity. J Med Chem. 2015 Nov 25; 58(22):8970-84. PMID: 26506089.
      View in: PubMed
    7. Munoz WA, Lee M, Miller RK, Ahmed Z, Ji H, Link TM, Lee GR, Kloc M, Ladbury JE, McCrea PD. Plakophilin-3 catenin associates with the ETV1/ER81 transcription factor to positively modulate gene activity. PLoS One. 2014; 9(1):e86784. PMID: 24475179.
      View in: PubMed
    8. Robinson KE, Orans J, Kovach AR, Link TM, Brennan RG. Mapping Hfq-RNA interaction surfaces using tryptophan fluorescence quenching. Nucleic Acids Res. 2014 Feb; 42(4):2736-49. PMID: 24288369.
      View in: PubMed
    9. Chen G, Link TM, Shi MF, Tyan T. Modeling of material orientation effects on AHSS crush and fracture behavior in axial crush tests. Traffic Inj Prev. 2013; 14 Suppl:S23-9. PMID: 23906382.
      View in: PubMed
    10. Schumacher MA, Min J, Link TM, Guan Z, Xu W, Ahn YH, Soderblom EJ, Kurie JM, Evdokimov A, Moseley MA, Lewis K, Brennan RG. Role of unusual P loop ejection and autophosphorylation in HipA-mediated persistence and multidrug tolerance. Cell Rep. 2012 Sep 27; 2(3):518-25. PMID: 22999936.
      View in: PubMed
    11. Link TM, Valentin-Hansen P, Brennan RG. Structure of Escherichia coli Hfq bound to polyriboadenylate RNA. Proc Natl Acad Sci U S A. 2009 Nov 17; 106(46):19292-7. PMID: 19889981.
      View in: PubMed
    12. Amen M, Espinoza HM, Cox C, Liang X, Wang J, Link TM, Brennan RG, Martin JF, Amendt BA. Chromatin-associated HMG-17 is a major regulator of homeodomain transcription factor activity modulated by Wnt/beta-catenin signaling. Nucleic Acids Res. 2008 Feb; 36(2):462-76. PMID: 18045789.
      View in: PubMed
    13. Brennan RG, Link TM. Hfq structure, function and ligand binding. Curr Opin Microbiol. 2007 Apr; 10(2):125-33. PMID: 17395525.
      View in: PubMed
    14. Sakamaki T, Casimiro MC, Ju X, Quong AA, Katiyar S, Liu M, Jiao X, Li A, Zhang X, Lu Y, Wang C, Byers S, Nicholson R, Link T, Shemluck M, Yang J, Fricke ST, Novikoff PM, Papanikolaou A, Arnold A, Albanese C, Pestell R. Cyclin D1 determines mitochondrial function in vivo. Mol Cell Biol. 2006 Jul; 26(14):5449-69. PMID: 16809779.
      View in: PubMed
    15. Van Lanen SG, Kinzie SD, Matthieu S, Link T, Culp J, Iwata-Reuyl D. tRNA modification by S-adenosylmethionine:tRNA ribosyltransferase-isomerase. Assay development and characterization of the recombinant enzyme. J Biol Chem. 2003 Mar 21; 278(12):10491-9. PMID: 12533518.
      View in: PubMed
    16. Albanese C, Reutens AT, Bouzahzah B, Fu M, D'Amico M, Link T, Nicholson R, Depinho RA, Pestell RG. Sustained mammary gland-directed, ponasterone A-inducible expression in transgenic mice. FASEB J. 2000 May; 14(7):877-84. PMID: 10783141.
      View in: PubMed
    17. Chen XY, Link TM, Schramm VL. Ricin A-chain: kinetics, mechanism, and RNA stem-loop inhibitors. Biochemistry. 1998 Aug 18; 37(33):11605-13. PMID: 9708998.
      View in: PubMed
    18. Link T, Chen XY, Niu LH, Schramm VL. A hypothesis to explain the substrate reactivity of ribosomal and stem-loop RNA with ricin A-chain. Toxicon. 1996 Nov-Dec; 34(11-12):1317-24. PMID: 9027988.
      View in: PubMed
    19. Structural basis of cyclic nucleotide selectivity in cGMP-dependent Protein Kinase II. Journal of Biological Chemistry. 291:5623-5633.
    20. Inhibition of ricin by an rna stem-loop containing a ribo-oxycarbonium mimic. FASEB Journal. 10.
    21. The transition state for RNA depurination by ricin a-chain. FASEB Journal. 11.
    22. Organic Preparations and Procedures International. 26:696-701.
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