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MICHAEL J TUVIM

TitleProfessor
InstitutionMD Anderson
DepartmentPulmonary Medicine
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    1. Wali S, Flores JR, Jaramillo AM, Goldblatt DL, Pantaleón García J, Tuvim MJ, Dickey BF, Evans SE. Immune Modulation to Improve Survival of Viral Pneumonia in Mice. Am J Respir Cell Mol Biol. 2020 Aug 27. PMID: 32853024.
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    2. Danahay H, Fox R, Lilley S, Charlton H, Adley K, Christie L, Ansari E, Ehre C, Flen A, Tuvim MJ, Dickey BF, Williams C, Beaudoin S, Collingwood SP, Gosling M. Potentiating TMEM16A does not stimulate airway mucus secretion or bronchial and pulmonary arterial smooth muscle contraction. FASEB Bioadv. 2020 Aug; 2(8):464-477. PMID: 32821878.
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    3. Goldblatt DL, Flores JR, Valverde Ha G, Jaramillo AM, Tkachman S, Kirkpatrick CT, Wali S, Hernandez B, Ost DE, Scott BL, Chen J, Evans SE, Tuvim MJ, Dickey BF. Inducible epithelial resistance against acute Sendai virus infection prevents chronic asthma-like lung disease in mice. Br J Pharmacol. 2020 May; 177(10):2256-2273. PMID: 31968123.
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    4. Kirkpatrick CT, Wang Y, Leiva Juarez MM, Shivshankar P, Pantaleón García J, Plumer AK, Kulkarni VV, Ware HH, Gulraiz F, Chavez Cavasos MA, Martinez Zayas G, Wali S, Rice AP, Liu H, Tour JM, Sikkema WKA, Cruz Solbes AS, Youker KA, Tuvim MJ, Dickey BF, Evans SE. Erratum for Kirkpatrick et al., "Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections". mBio. 2019 04 02; 10(2). PMID: 30940707.
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    5. Jaramillo AM, Piccotti L, Velasco WV, Delgado ASH, Azzegagh Z, Chung F, Nazeer U, Farooq J, Brenner J, Parker-Thornburg J, Scott BL, Evans CM, Adachi R, Burns AR, Kreda SM, Tuvim MJ, Dickey BF. Different Munc18 proteins mediate baseline and stimulated airway mucin secretion. JCI Insight. 2019 03 21; 4(6). PMID: 30721150.
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    6. Vichaya EG, Gross PS, Estrada DJ, Cole SW, Grossberg AJ, Evans SE, Tuvim MJ, Dickey BF, Dantzer R. Lipocalin-2 is dispensable in inflammation-induced sickness and depression-like behavior. Psychopharmacology (Berl). 2019 Oct; 236(10):2975-2982. PMID: 30806746.
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    7. Jaramillo AM, Azzegagh Z, Tuvim MJ, Dickey BF. Airway Mucin Secretion. Ann Am Thorac Soc. 2018 11; 15(Suppl 3):S164-S170. PMID: 30431339.
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    8. Winkelmann VE, Thompson KE, Neuland K, Jaramillo AM, Fois G, Schmidt H, Wittekindt OH, Han W, Tuvim MJ, Dickey BF, Dietl P, Frick M. Inflammation-induced upregulation of P2X4 expression augments mucin secretion in airway epithelia. Am J Physiol Lung Cell Mol Physiol. 2019 01 01; 316(1):L58-L70. PMID: 30358443.
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    9. De la Garza MM, Cumpian AM, Daliri S, Castro-Pando S, Umer M, Gong L, Khosravi N, Caetano MS, Ramos-Castañeda M, Flores AG, Beltran EC, Tran HT, Tuvim MJ, Ostrin EJ, Dickey BF, Evans CM, Moghaddam SJ. COPD-Type lung inflammation promotes K-ras mutant lung cancer through epithelial HIF-1a mediated tumor angiogenesis and proliferation. Oncotarget. 2018 Aug 31; 9(68):32972-32983. PMID: 30250643.
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    10. Kirkpatrick CT, Wang Y, Leiva Juarez MM, Shivshankar P, Pantaleón García J, Plumer AK, Kulkarni VV, Ware HH, Gulraiz F, Chavez Cavasos MA, Martinez Zayas G, Wali S, Rice AP, Liu H, Tour JM, Sikkema WKA, Cruz Solbes AS, Youker KA, Tuvim MJ, Dickey BF, Evans SE. Inducible Lung Epithelial Resistance Requires Multisource Reactive Oxygen Species Generation To Protect against Viral Infections. mBio. 2018 05 15; 9(3). PMID: 29764948.
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    11. Cardenas EI, Breaux K, Da Q, Flores JR, Ramos MA, Tuvim MJ, Burns AR, Rumbaut RE, Adachi R. Platelet Munc13-4 regulates hemostasis, thrombosis and airway inflammation. Haematologica. 2018 07; 103(7):1235-1244. PMID: 29674495.
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    12. Gutierrez BA, Chavez MA, Rodarte AI, Ramos MA, Dominguez A, Petrova Y, Davalos AJ, Costa RM, Elizondo R, Tuvim MJ, Dickey BF, Burns AR, Heidelberger R, Adachi R. Munc18-2, but not Munc18-1 or Munc18-3, controls compound and single-vesicle-regulated exocytosis in mast cells. J Biol Chem. 2018 05 11; 293(19):7148-7159. PMID: 29599294.
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    13. Rodarte EM, Ramos MA, Davalos AJ, Moreira DC, Moreno DS, Cardenas EI, Rodarte AI, Petrova Y, Molina S, Rendon LE, Sanchez E, Breaux K, Tortoriello A, Manllo J, Gonzalez EA, Tuvim MJ, Dickey BF, Burns AR, Heidelberger R, Adachi R. Munc13 proteins control regulated exocytosis in mast cells. J Biol Chem. 2018 01 05; 293(1):345-358. PMID: 29141910.
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    14. Leiva-Juarez MM, Kirkpatrick CT, Gilbert BE, Scott B, Tuvim MJ, Dickey BF, Evans SE, Markesich D. Combined aerosolized Toll-like receptor ligands are an effective therapeutic agent against influenza pneumonia when co-administered with oseltamivir. Eur J Pharmacol. 2018 Jan 05; 818:191-197. PMID: 29066417.
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    15. Nguyen LP, Al-Sawalha NA, Parra S, Pokkunuri I, Omoluabi O, Okulate AA, Windham Li E, Hazen M, Gonzalez-Granado JM, Daly CJ, McGrath JC, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. ß2-Adrenoceptor signaling in airway epithelial cells promotes eosinophilic inflammation, mucous metaplasia, and airway contractility. Proc Natl Acad Sci U S A. 2017 10 24; 114(43):E9163-E9171. PMID: 29073113.
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    16. Leiva-Juárez MM, Ware HH, Kulkarni VV, Zweidler-McKay PA, Tuvim MJ, Evans SE. Inducible epithelial resistance protects mice against leukemia-associated pneumonia. Blood. 2016 08 18; 128(7):982-92. PMID: 27317793.
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    17. Ren B, Azzegagh Z, Jaramillo AM, Zhu Y, Pardo-Saganta A, Bagirzadeh R, Flores JR, Han W, Tang YJ, Tu J, Alanis DM, Evans CM, Guindani M, Roche PA, Rajagopal J, Chen J, Davis CW, Tuvim MJ, Dickey BF. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. Biosci Rep. 2015 Apr 28; 35(3). PMID: 26182382.
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    18. Evans CM, Raclawska DS, Ttofali F, Liptzin DR, Fletcher AA, Harper DN, McGing MA, McElwee MM, Williams OW, Sanchez E, Roy MG, Kindrachuk KN, Wynn TA, Eltzschig HK, Blackburn MR, Tuvim MJ, Janssen WJ, Schwartz DA, Dickey BF. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nat Commun. 2015 Feb 17; 6:6281. PMID: 25687754.
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    19. Walker AK, Hsieh J, Luu KV, Radwan AA, Valverde GR, Dickey BF, Tuvim MJ, Dantzer R. Activation of lung toll-like receptors does not exacerbate sickness responses to lipopolysaccharide in mice. Brain Behav Immun. 2014 May; 38:211-9. PMID: 24534636.
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    20. Alfaro VY, Goldblatt DL, Valverde GR, Munsell MF, Quinton LJ, Walker AK, Dantzer R, Varadhachary A, Scott BL, Evans SE, Tuvim MJ, Dickey BF. Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands. Front Pharmacol. 2014; 5:8. PMID: 24567720.
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    21. Roy MG, Livraghi-Butrico A, Fletcher AA, McElwee MM, Evans SE, Boerner RM, Alexander SN, Bellinghausen LK, Song AS, Petrova YM, Tuvim MJ, Adachi R, Romo I, Bordt AS, Bowden MG, Sisson JH, Woodruff PG, Thornton DJ, Rousseau K, De la Garza MM, Moghaddam SJ, Karmouty-Quintana H, Blackburn MR, Drouin SM, Davis CW, Terrell KA, Grubb BR, O'Neal WK, Flores SC, Cota-Gomez A, Lozupone CA, Donnelly JM, Watson AM, Hennessy CE, Keith RC, Yang IV, Barthel L, Henson PM, Janssen WJ, Schwartz DA, Boucher RC, Dickey BF, Evans CM. Muc5b is required for airway defence. Nature. 2014 Jan 16; 505(7483):412-6. PMID: 24317696.
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    22. Adler KB, Tuvim MJ, Dickey BF. Regulated mucin secretion from airway epithelial cells. Front Endocrinol (Lausanne). 2013 Sep 18; 4:129. PMID: 24065956.
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    23. Tuvim MJ, Clement CG, Huang ES, Cote GJ, Evans SE, Lei X, Deftos LJ, Gagel RF, Dickey BF. Deletion of the gene encoding calcitonin and calcitonin gene-related peptide a does not affect the outcome of severe infection in mice. Am J Respir Cell Mol Biol. 2013 Jul; 49(1):151-5. PMID: 23526213.
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    24. Cleaver JO, You D, Michaud DR, Pruneda FA, Juarez MM, Zhang J, Weill PM, Adachi R, Gong L, Moghaddam SJ, Poynter ME, Tuvim MJ, Evans SE. Lung epithelial cells are essential effectors of inducible resistance to pneumonia. Mucosal Immunol. 2014 Jan; 7(1):78-88. PMID: 23632328.
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    25. Thanawala VJ, Forkuo GS, Al-Sawalha N, Azzegagh Z, Nguyen LP, Eriksen JL, Tuvim MJ, Lowder TW, Dickey BF, Knoll BJ, Walker JK, Bond RA. ß2-Adrenoceptor agonists are required for development of the asthma phenotype in a murine model. Am J Respir Cell Mol Biol. 2013 Feb; 48(2):220-9. PMID: 23204390.
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    26. Kim K, Petrova YM, Scott BL, Nigam R, Agrawal A, Evans CM, Azzegagh Z, Gomez A, Rodarte EM, Olkkonen VM, Bagirzadeh R, Piccotti L, Ren B, Yoon JH, McNew JA, Adachi R, Tuvim MJ, Dickey BF. Munc18b is an essential gene in mice whose expression is limiting for secretion by airway epithelial and mast cells. Biochem J. 2012 Sep 15; 446(3):383-94. PMID: 22694344.
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    27. Tuvim MJ, Gilbert BE, Dickey BF, Evans SE. Synergistic TLR2/6 and TLR9 activation protects mice against lethal influenza pneumonia. PLoS One. 2012; 7(1):e30596. PMID: 22299046.
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    28. Nguyen LP, Singh B, Okulate AA, Alfaro VY, Tuvim MJ, Dickey BF, Bond RA. Complementary anti-inflammatory effects of a ß-blocker and a corticosteroid in an asthma model. Naunyn Schmiedebergs Arch Pharmacol. 2012 Feb; 385(2):203-10. PMID: 21964666.
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    29. Evans SE, Tuvim MJ, Fox CJ, Sachdev N, Gibiansky L, Dickey BF. Inhaled innate immune ligands to prevent pneumonia. Br J Pharmacol. 2011 May; 163(1):195-206. PMID: 21250981.
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    30. Duggan JM, You D, Cleaver JO, Larson DT, Garza RJ, Guzmán Pruneda FA, Tuvim MJ, Zhang J, Dickey BF, Evans SE. Synergistic interactions of TLR2/6 and TLR9 induce a high level of resistance to lung infection in mice. J Immunol. 2011 May 15; 186(10):5916-26. PMID: 21482737.
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    31. Evans SE, Tuvim MJ, Zhang J, Larson DT, García CD, Martinez-Pro S, Coombes KR, Dickey BF. Host lung gene expression patterns predict infectious etiology in a mouse model of pneumonia. Respir Res. 2010 Jul 23; 11:101. PMID: 20653947.
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    32. Evans SE, Xu Y, Tuvim MJ, Dickey BF. Inducible innate resistance of lung epithelium to infection. Annu Rev Physiol. 2010; 72:413-35. PMID: 20148683.
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    33. Moghaddam SJ, Barta P, Mirabolfathinejad SG, Ammar-Aouchiche Z, Garza NT, Vo TT, Newman RA, Aggarwal BB, Evans CM, Tuvim MJ, Lotan R, Dickey BF. Curcumin inhibits COPD-like airway inflammation and lung cancer progression in mice. Carcinogenesis. 2009 Nov; 30(11):1949-56. PMID: 19793800.
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    34. Clement CG, Tuvim MJ, Evans CM, Tuvin DM, Dickey BF, Evans SE. Allergic lung inflammation alters neither susceptibility to Streptococcus pneumoniae infection nor inducibility of innate resistance in mice. Respir Res. 2009 Jul 27; 10:70. PMID: 19635139.
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    35. Evans SE, Scott BL, Clement CG, Larson DT, Kontoyiannis D, Lewis RE, Lasala PR, Pawlik J, Peterson JW, Chopra AK, Klimpel G, Bowden G, Höök M, Xu Y, Tuvim MJ, Dickey BF. Stimulated innate resistance of lung epithelium protects mice broadly against bacteria and fungi. Am J Respir Cell Mol Biol. 2010 Jan; 42(1):40-50. PMID: 19329554.
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    36. Tuvim MJ, Mospan AR, Burns KA, Chua M, Mohler PJ, Melicoff E, Adachi R, Ammar-Aouchiche Z, Davis CW, Dickey BF. Synaptotagmin 2 couples mucin granule exocytosis to Ca2+ signaling from endoplasmic reticulum. J Biol Chem. 2009 Apr 10; 284(15):9781-7. PMID: 19208631.
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    37. Nguyen LP, Lin R, Parra S, Omoluabi O, Hanania NA, Tuvim MJ, Knoll BJ, Dickey BF, Bond RA. Beta2-adrenoceptor signaling is required for the development of an asthma phenotype in a murine model. Proc Natl Acad Sci U S A. 2009 Feb 17; 106(7):2435-40. PMID: 19171883.
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    38. Tuvim MJ, Evans SE, Clement CG, Dickey BF, Gilbert BE. Augmented lung inflammation protects against influenza A pneumonia. PLoS One. 2009; 4(1):e4176. PMID: 19137067.
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    39. Evans CM, Kim K, Tuvim MJ, Dickey BF. Mucus hypersecretion in asthma: causes and effects. Curr Opin Pulm Med. 2009 Jan; 15(1):4-11. PMID: 19077699.
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    40. Russell BH, Liu Q, Jenkins SA, Tuvim MJ, Dickey BF, Xu Y. In vivo demonstration and quantification of intracellular Bacillus anthracis in lung epithelial cells. Infect Immun. 2008 Sep; 76(9):3975-83. PMID: 18625737.
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    41. Clement CG, Evans SE, Evans CM, Hawke D, Kobayashi R, Reynolds PR, Moghaddam SJ, Scott BL, Melicoff E, Adachi R, Dickey BF, Tuvim MJ. Stimulation of lung innate immunity protects against lethal pneumococcal pneumonia in mice. Am J Respir Crit Care Med. 2008 Jun 15; 177(12):1322-30. PMID: 18388354.
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    42. Moghaddam SJ, Clement CG, De la Garza MM, Zou X, Travis EL, Young HW, Evans CM, Tuvim MJ, Dickey BF. Haemophilus influenzae lysate induces aspects of the chronic obstructive pulmonary disease phenotype. Am J Respir Cell Mol Biol. 2008 Jun; 38(6):629-38. PMID: 18096867.
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    43. Nguyen LP, Omoluabi O, Parra S, Frieske JM, Clement C, Ammar-Aouchiche Z, Ho SB, Ehre C, Kesimer M, Knoll BJ, Tuvim MJ, Dickey BF, Bond RA. Chronic exposure to beta-blockers attenuates inflammation and mucin content in a murine asthma model. Am J Respir Cell Mol Biol. 2008 Mar; 38(3):256-62. PMID: 18096872.
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    44. Young HW, Williams OW, Chandra D, Bellinghausen LK, Pérez G, Suárez A, Tuvim MJ, Roy MG, Alexander SN, Moghaddam SJ, Adachi R, Blackburn MR, Dickey BF, Evans CM. Central role of Muc5ac expression in mucous metaplasia and its regulation by conserved 5' elements. Am J Respir Cell Mol Biol. 2007 Sep; 37(3):273-90. PMID: 17463395.
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    45. Nigam R, Sepulveda J, Tuvim M, Petrova Y, Adachi R, Dickey BF, Agrawal A. Expression and transcriptional regulation of Munc18 isoforms in mast cells. Biochim Biophys Acta. 2005 Apr 05; 1728(1-2):77-83. PMID: 15777698.
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    46. Romero EJ, Moya FR, Tuvim MJ, Alcorn JL. Interaction of an artificial surfactant in human pulmonary epithelial cells. Pediatr Pulmonol. 2005 Feb; 39(2):167-77. PMID: 15633204.
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    47. Evans CM, Williams OW, Tuvim MJ, Nigam R, Mixides GP, Blackburn MR, DeMayo FJ, Burns AR, Smith C, Reynolds SD, Stripp BR, Dickey BF. Mucin is produced by clara cells in the proximal airways of antigen-challenged mice. Am J Respir Cell Mol Biol. 2004 Oct; 31(4):382-94. PMID: 15191915.
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    48. Evans C, Kheradmand F, Corry D, Tuvim M, Densmore C, Waldrep C, Knight V, Dickey B. Gene therapy of mucus hypersecretion in experimental asthma. Chest. 2002 Mar; 121(3 Suppl):90S-91S. PMID: 11893719.
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    49. van IJzendoorn SC, Tuvim MJ, Weimbs T, Dickey BF, Mostov KE. Direct interaction between Rab3b and the polymeric immunoglobulin receptor controls ligand-stimulated transcytosis in epithelial cells. Dev Cell. 2002 Feb; 2(2):219-28. PMID: 11832247.
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    50. Tuvim MJ, Adachi R, Hoffenberg S, Dickey BF. Traffic control: Rab GTPases and the regulation of interorganellar transport. News Physiol Sci. 2001 Apr; 16:56-61. PMID: 11390949.
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    51. Agrawal A, Adachi R, Tuvim M, Yan XT, Teich AH, Dickey BF. Gene structure and promoter function of murine Munc18-2, a nonneuronal exocytic Sec1 homolog. Biochem Biophys Res Commun. 2000 Oct 05; 276(3):817-22. PMID: 11027553.
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    52. Adachi R, Nigam R, Tuvim MJ, DeMayo F, Dickey BF. Genomic organization, chromosomal localization, and expression of the murine RAB3D gene. Biochem Biophys Res Commun. 2000 Jul 14; 273(3):877-83. PMID: 10891340.
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    53. Baram D, Adachi R, Medalia O, Tuvim M, Dickey BF, Mekori YA, Sagi-Eisenberg R. Synaptotagmin II negatively regulates Ca2+-triggered exocytosis of lysosomes in mast cells. J Exp Med. 1999 May 17; 189(10):1649-58. PMID: 10330444.
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    54. Tuvim MJ, Adachi R, Chocano JF, Moore RH, Lampert RM, Zera E, Romero E, Knoll BJ, Dickey BF. Rab3D, a small GTPase, is localized on mast cell secretory granules and translocates to the plasma membrane upon exocytosis. Am J Respir Cell Mol Biol. 1999 Jan; 20(1):79-89. PMID: 9870920.
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    55. Morrison KJ, Moore RH, Carsrud ND, Trial J, Millman EE, Tuvim M, Clark RB, Barber R, Dickey BF, Knoll BJ. Repetitive endocytosis and recycling of the beta 2-adrenergic receptor during agonist-induced steady state redistribution. Mol Pharmacol. 1996 Sep; 50(3):692-9. PMID: 8794912.
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    56. Safety, tolerability, and biomarkers of the treatment of mice with aerosolized Toll-like receptor ligands. Frontiers in Pharmacology. 5 FEB.
    57. Regulated mucin secretion from airway epithelial cells. Frontiers in Endocrinology. 4.
    58. The polymeric mucin Muc5ac is required for allergic airway hyperreactivity. Nature Communications. 6.
    59. SNAP23 is selectively expressed in airway secretory cells and mediates baseline and stimulated mucin secretion. Bioscience Reports. 35.
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