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Jayarathna S, Kaphle A, Krishnan S, Cho SH. Nanoscale gold nanoparticle (GNP)-laden tumor cell model and its use for estimation of intracellular dose from GNP-induced secondary electrons. Med Phys. 2024 Sep; 51(9):6276-6291.
PMID: 38935922; PMCID: PMC11489034.
Citations: Fields:
Translation:
HumansCells
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Schwartz-Duval AS, Mackeyev Y, Mahmud I, Lorenzi PL, Gagea M, Krishnan S, Sokolov KV. Intratumoral Biosynthesis of Gold Nanoclusters by Pancreatic Cancer to Overcome Delivery Barriers to Radiosensitization. ACS Nano. 2024 Jan 23; 18(3):1865-1881.
PMID: 38206058; PMCID: PMC10811688.
Citations:
1 Fields:
Translation:
Animals
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Lee CH, Huang HC, Wu SW, Chou CY, Hung SP, Lee CW, Lee JC, Chan KM, Lin PT, Lee WC, Lin CC, Lin SY, Hong JH, Hsieh RC, Krishnan S, Venkatesulu BP, Chou YC. Clinical and Dosimetric Results of Proton or Photon Radiation Therapy for Large (>5 cm) Hepatocellular Carcinoma: A Retrospective Analysis. Int J Radiat Oncol Biol Phys. 2024 Mar 01; 118(3):712-724.
PMID: 37778426.
Citations: Fields:
Translation:
HumansPHPublic Health
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Jain A, Casanova D, Padilla AV, Paniagua Bojorges A, Kotla S, Ko KA, Samanthapudi VSK, Chau K, Nguyen MTH, Wen J, Hernandez Gonzalez SL, Rodgers SP, Olmsted-Davis EA, Hamilton DJ, Reyes-Gibby C, Yeung SJ, Cooke JP, Herrmann J, Chini EN, Xu X, Yusuf SW, Yoshimoto M, Lorenzi PL, Hobbs B, Krishnan S, Koutroumpakis E, Palaskas NL, Wang G, Deswal A, Lin SH, Abe JI, Le NT. Premature senescence and cardiovascular disease following cancer treatments: mechanistic insights. Front Cardiovasc Med. 2023; 10:1212174.
PMID: 37781317; PMCID: PMC10540075.
Citations:
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Kaphle A, Jayarathna S, Moktan H, Aliru M, Raghuram S, Krishnan S, Cho SH. Deep Learning-Based TEM Image Analysis for Fully Automated Detection of Gold Nanoparticles Internalized Within Tumor Cell. Microsc Microanal. 2023 07 25; 29(4):1474-1487.
PMID: 37488822; PMCID: PMC10433944.
Citations:
1 Fields:
Translation:
Humans
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Abe JI, Imanishi M, Li S, Zhang A, Ko KA, Samanthapudi VSK, Lee LL, Bojorges AP, Gi YJ, Hobbs BP, Deswal A, Herrmann J, Lin SH, Chini EN, Shen YH, Schadler KL, Nguyen TH, Gupte AA, Reyes-Gibby C, Yeung SJ, Abe RJ, Olmsted-Davis EA, Krishnan S, Dantzer R, Palaskas NL, Cooke JP, Pownall HJ, Yoshimoto M, Fujiwara K, Hamilton DJ, Burks JK, Wang G, Le NT, Kotla S. An ERK5-NRF2 Axis Mediates Senescence-Associated Stemness and Atherosclerosis. Circ Res. 2023 06 23; 133(1):25-44.
PMID: 37264926; PMCID: PMC10357365.
Citations:
3 Fields:
Translation:
Animals
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Gunther JR, Chadha AS, Guha S, Raju GS, Maru DM, Munsell MF, Jiang Y, Yang P, Felix E, Clemons M, Mathew GG, Singh PK, Skibber JM, Rodriguez-Bigas MA, Chang GJ, Eng C, Delclos ME, Crane CH, Das P, Krishnan S. A phase II randomized double blinded trial evaluating the efficacy of curcumin with pre-operative chemoradiation for rectal cancer. J Gastrointest Oncol. 2022 Dec; 13(6):2938-2950.
PMID: 36636059; PMCID: PMC9830363.
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Rauta PR, Mackeyev Y, Sanders K, Kim JBK, Gonzalez VV, Zahra Y, Shohayeb MA, Abousaida B, Vijay GV, Tezcan O, Derry P, Liopo AV, Zubarev ER, Carter R, Singh P, Krishnan S. Pancreatic tumor microenvironmental acidosis and hypoxia transform gold nanorods into cell-penetrant particles for potent radiosensitization. Sci Adv. 2022 11 11; 8(45):eabm9729.
PMID: 36367938; PMCID: PMC9651859.
Citations:
1 Fields:
Translation:
AnimalsCells
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Raghuram S, Mackeyev Y, Symons J, Zahra Y, Gonzalez V, Mahadevan KK, Requejo KI, Liopo A, Derry P, Zubarev E, Sahin O, Byung-Kyu Kim J, Singh PK, Cho SH, Krishnan S. Uncloaking cell-impermeant gold nanorods via tumor microenvironmental cathepsin B facilitates cancer cell penetration and potent radiosensitization. Biomaterials. 2022 12; 291:121887.
PMID: 36368139; PMCID: PMC10032210.
Citations:
1 Fields:
Translation:
Animals
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Koay EJ, Zaid M, Aliru M, Bagereka P, Van Wieren A, Rodriguez MJ, Jacobson G, Wolff RA, Overman M, Varadhachary G, Pant S, Wang H, Tzeng CW, Ikoma N, Kim M, Lee JE, Katz MH, Tamm E, Bhosale P, Taniguchi CM, Holliday EB, Smith GL, Ludmir EB, Minsky BD, Crane CH, Koong AC, Das P, Wang X, Javle M, Krishnan S. Nab-Paclitaxel, Capecitabine, and Radiation Therapy After Induction Chemotherapy in Treating Patients With Locally Advanced and Borderline Resectable Pancreatic Cancer: Phase 1 Trial and Imaging-based Biomarker Validation. Int J Radiat Oncol Biol Phys. 2022 11 01; 114(3):444-453.
PMID: 35863672.
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Hsieh RC, Krishnan S, Wu RC, Boda AR, Liu A, Winkler M, Hsu WH, Lin SH, Hung MC, Chan LC, Bhanu KR, Srinivasamani A, De Azevedo RA, Chou YC, DePinho RA, Gubin M, Vilar E, Chen CH, Slay R, Jayaprakash P, Hegde SM, Hartley G, Lea ST, Prasad R, Morrow B, Couillault CA, Steiner M, Wang CC, Venkatesulu BP, Taniguchi C, Kim YSB, Chen J, Rudqvist NP, Curran MA. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol. 2022 06 10; 7(72):eabl9330.
PMID: 35687697; PMCID: PMC9373855.
Citations: Fields:
Translation:
HumansAnimalsCells
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Bhattarai S, Mackeyev Y, Venkatesulu BP, Krishnan S, Singh PK. CXC chemokine receptor 4 (CXCR4) targeted gold nanoparticles potently enhance radiotherapy outcomes in breast cancer. Nanoscale. 2021 Nov 25; 13(45):19056-19065.
PMID: 34757363; PMCID: PMC9124374.
Citations:
1 Fields:
Translation:
HumansAnimalsCells
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Kotla S, Zhang A, Imanishi M, Ko KA, Lin SH, Gi YJ, Moczygemba M, Isgandarova S, Schadler KL, Chung C, Milgrom SA, Banchs J, Yusuf SW, Amaya DN, Guo H, Thomas TN, Shen YH, Deswal A, Herrmann J, Kleinerman ES, Entman ML, Cooke JP, Schifitto G, Maggirwar SB, McBeath E, Gupte AA, Krishnan S, Patel ZS, Yoon Y, Burks JK, Fujiwara K, Brookes PS, Le NT, Hamilton DJ, Abe JI. Nucleus-mitochondria positive feedback loop formed by ERK5 S496 phosphorylation-mediated poly (ADP-ribose) polymerase activation provokes persistent pro-inflammatory senescent phenotype and accelerates coronary atherosclerosis after chemo-radiation. Redox Biol. 2021 11; 47:102132.
PMID: 34619528; PMCID: PMC8502954.
Citations:
1 Fields:
Translation:
HumansAnimalsCells
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Lin SH, Willers H, Krishnan S, Sarkaria JN, Baumann M, Lawrence TS. Moving Beyond the Standard of Care: Accelerate Testing of Radiation-Drug Combinations. Int J Radiat Oncol Biol Phys. 2021 12 01; 111(5):1131-1139.
PMID: 34454045; PMCID: PMC9159468.
Citations:
2 Fields:
Translation:
Humans
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Ye R, Qiao Y, Singh PK, Wang Y, He J, Li N, Krishnan S, Lin SH. High-Content Clonogenic Survival Screen to Identify Chemoradiation Sensitizers. Int J Radiat Oncol Biol Phys. 2021 12 01; 111(5):e27-e37.
PMID: 34348174; PMCID: PMC9986843.
Citations:
1 Fields:
Translation:
Humans
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Dayde D, Gunther J, Hirayama Y, Weksberg DC, Boutin A, Parhy G, Aguilar-Bonavides C, Wang H, Katayama H, Abe Y, Do KA, Hara K, Kinoshita T, Komori K, Shimizu Y, Tajika M, Niwa Y, Wang YA, DePinho R, Hanash S, Krishnan S, Taguchi A. Identification of Blood-Based Biomarkers for the Prediction of the Response to Neoadjuvant Chemoradiation in Rectal Cancer. Cancers (Basel). 2021 Jul 20; 13(14).
PMID: 34298853; PMCID: PMC8306983.
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Wang J, Salzillo T, Jiang Y, Mackeyev Y, David Fuller C, Chung C, Choi S, Hughes N, Ding Y, Yang J, Vedam S, Krishnan S. Stability of MRI contrast agents in high-energy radiation of a 1.5T MR-Linac. Radiother Oncol. 2021 08; 161:55-64.
PMID: 34089753; PMCID: PMC8324543.
Citations:
3 Fields:
Translation:
Humans
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Kaur H, Gabriel H, Taggart M, Kang HC, Konishi T, Rauch GM, Krishnan S, Chang G. MRI Staging in an Evolving Management Paradigm for Rectal Cancer, From the AJR Special Series on Cancer Staging. AJR Am J Roentgenol. 2021 12; 217(6):1282-1293.
PMID: 33949877.
Citations:
2 Fields:
Translation:
Humans
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De B, Ng SP, Liu AY, Avila S, Tao R, Holliday EB, Brownlee Z, Kaseb A, Lee S, Raghav K, Vauthey JN, Minsky BD, Herman JM, Das P, Smith GL, Taniguchi CM, Krishnan S, Crane CH, Grassberger C, Hong TS, Lin SH, Koong AC, Mohan R, Koay EJ. Radiation-Associated Lymphopenia and Outcomes of Patients with Unresectable Hepatocellular Carcinoma Treated with Radiotherapy. J Hepatocell Carcinoma. 2021; 8:57-69.
PMID: 33688489; PMCID: PMC7937383.
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Angelidakis G, Krishnan S, Cabrera NL, Jiang Y, Pushparaji B, Kaseb A, Torres HA. Virologic Impact of Radiotherapy in Hepatitis C Virus-Infected Patients With Hepatocellular Carcinoma. Hepatology. 2020 08; 72(2):775-777.
PMID: 31944343.
Citations:
1 Fields:
Translation:
HumansCells
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Venkatesulu BP, Sharma A, Pollard-Larkin JM, Sadagopan R, Symons J, Neri S, Singh PK, Tailor R, Lin SH, Krishnan S. Author Correction: Ultra high dose rate (35?Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome. Sci Rep. 2020 Jun 30; 10(1):11018.
PMID: 32601350; PMCID: PMC7324618.
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Avila S, Chang GJ, Dasari NA, Smani DA, Das P, Herman JM, Koay E, Koong A, Krishnan S, Minsky BD, Smith GL, Taniguchi C, Taggart MW, Kaur H, Holliday EB. Pathologic Response and Postoperative Complications After Short-course Radiation Therapy and Chemotherapy for Patients With Rectal Adenocarcinoma. Clin Colorectal Cancer. 2020 06; 19(2):116-122.
PMID: 32173279; PMCID: PMC7370689.
Citations: Fields:
Translation:
Humans
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Ayala Orozco C, Liu D, Li Y, Alemany LB, Pal R, Krishnan S, Tour JM. Visible-Light-Activated Molecular Nanomachines Kill Pancreatic Cancer Cells. ACS Appl Mater Interfaces. 2020 Jan 08; 12(1):410-417.
PMID: 31815419.
Citations:
3 Fields:
Translation:
HumansAnimalsCells
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Veeranki OL, Tong Z, Mejia A, Verma A, Katkhuda R, Bassett R, Kim TB, Wang J, Lang W, Mino B, Solis L, Kingsley C, Norton W, Tailor R, Wu JY, Krishnan S, Lin SH, Blum M, Hofstetter W, Ajani J, Kopetz S, Maru D. A novel patient-derived orthotopic xenograft model of esophageal adenocarcinoma provides a platform for translational discoveries. Dis Model Mech. 2019 12 17; 12(12).
PMID: 31732509; PMCID: PMC6918774.
Citations:
6 Fields:
Translation:
HumansAnimalsCells
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Moningi S, Ajani JA, Badgwell BD, Murphy MB, Ikoma N, Mansfield PF, Ho JC, Suh Y, Crane C, Herman JM, Holliday EB, Koay E, Koong AC, Krishnan S, Minsky B, Smith G, Taniguchi C, Das P. IMRT Reduces Acute Toxicity in Patients Treated With Preoperative Chemoradiation for Gastric Cancer. Adv Radiat Oncol. 2020 May-Jun; 5(3):369-376.
PMID: 32529130; PMCID: PMC7276694.
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Venkatesulu BP, Sharma A, Pollard-Larkin JM, Sadagopan R, Symons J, Neri S, Singh PK, Tailor R, Lin SH, Krishnan S. Ultra high dose rate (35?Gy/sec) radiation does not spare the normal tissue in cardiac and splenic models of lymphopenia and gastrointestinal syndrome. Sci Rep. 2019 11 20; 9(1):17180.
PMID: 31748640; PMCID: PMC6868225.
Citations:
10 Fields:
Translation:
AnimalsCellsPHPublic Health
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Habiba K, Aziz K, Sanders K, Santiago CM, Mahadevan LSK, Makarov V, Weiner BR, Morell G, Krishnan S. Enhancing Colorectal Cancer Radiation Therapy Efficacy using Silver Nanoprisms Decorated with Graphene as Radiosensitizers. Sci Rep. 2019 11 19; 9(1):17120.
PMID: 31745177; PMCID: PMC6864075.
Citations:
9 Fields:
Translation:
HumansAnimalsCells
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Li Y, Ayala-Orozco C, Rauta PR, Krishnan S. The application of nanotechnology in enhancing immunotherapy for cancer treatment: current effects and perspective. Nanoscale. 2019 Oct 07; 11(37):17157-17178.
PMID: 31531445; PMCID: PMC6778734.
Citations:
9 Fields:
Translation:
Humans
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Choi GW, Suh Y, Das P, Herman J, Holliday E, Koay E, Koong AC, Krishnan S, Minsky BD, Smith GL, Taniguchi CM, Beddar S. Assessment of setup uncertainty in hypofractionated liver radiation therapy with a breath-hold technique using automatic image registration-based image guidance. Radiat Oncol. 2019 Aug 30; 14(1):154.
PMID: 31470860; PMCID: PMC6717376.
Citations:
4 Fields:
Translation:
Humans
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Moningi S, Ludmir EB, Polamraju P, Williamson T, Melkun MM, Herman JD, Krishnan S, Koay EJ, Koong AC, Minsky BD, Smith GL, Taniguchi C, Das P, Holliday EB. Definitive hyperfractionated, accelerated proton reirradiation for patients with pelvic malignancies. Clin Transl Radiat Oncol. 2019 Nov; 19:59-65.
PMID: 31517071; PMCID: PMC6734102.
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Koay EJ, Katz MHG, Wang H, Wang X, Prakash L, Javle M, Shroff R, Fogelman D, Avila S, Zaid M, Elganainy D, Lee Y, Crane CH, Krishnan S, Das P, Fleming JB, Lee JE, Tamm EP, Bhosale P, Lee JH, Weston B, Maitra A, Wolff RA, Varadhachary GR. Computed Tomography-Based Biomarker Outcomes in a Prospective Trial of Preoperative FOLFIRINOX and Chemoradiation for Borderline Resectable Pancreatic Cancer. JCO Precis Oncol. 2019; 3.
PMID: 32914036; PMCID: PMC7446521.
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Singh PK, Deorukhkar AA, Venkatesulu BP, Li X, Tailor R, Bomalaski JS, Krishnan S. Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation. Mol Cancer Ther. 2019 12; 18(12):2381-2393.
PMID: 31395686; PMCID: PMC6891156.
Citations:
11 Fields:
Translation:
HumansAnimalsCells
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Tong Z, Mejia A, Veeranki O, Verma A, Correa AM, Dokey R, Patel V, Solis LM, Mino B, Kathkuda R, Rodriguez-Canales J, Lin SH, Krishnan S, Kopetz S, Blum M, Ajani JA, Hofstetter WL, Maru DM. Targeting CDK9 and MCL-1 by a new CDK9/p-TEFb inhibitor with and without 5-fluorouracil in esophageal adenocarcinoma. Ther Adv Med Oncol. 2019; 11:1758835919864850.
PMID: 31384313; PMCID: PMC6659187.
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Veeranki OL, Tong Z, Dokey R, Mejia A, Zhang J, Qiao Y, Singh PK, Katkhuda R, Mino B, Tailor R, Canales JR, Bassett R, Ajani J, Wu JY, Kopetz S, Blum M, Hofstetter W, Tetzlaff M, Krishnan S, Lin SH, Maru D. Targeting cyclin-dependent kinase 9 by a novel inhibitor enhances radiosensitization and identifies Axl as a novel downstream target in esophageal adenocarcinoma. Oncotarget. 2019 Jul 23; 10(45):4703-4718.
PMID: 31384397; PMCID: PMC6659793.
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Jayarathna S, Manohar N, Ahmed MF, Krishnan S, Cho SH. Evaluation of dose point kernel rescaling methods for nanoscale dose estimation around gold nanoparticles using Geant4 Monte Carlo simulations. Sci Rep. 2019 03 05; 9(1):3583.
PMID: 30837578; PMCID: PMC6401138.
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Hsieh CE, Venkatesulu BP, Lee CH, Hung SP, Wong PF, Aithala SP, Kim BK, Rao A, Tung-Chieh Chang J, Tsang NM, Wang CC, Lee CC, Lin CC, Tseng JH, Chou WC, Wang YC, Krishnan S, Hong JH. Predictors of Radiation-Induced Liver Disease in Eastern and Western Patients With Hepatocellular Carcinoma Undergoing Proton Beam Therapy. Int J Radiat Oncol Biol Phys. 2019 09 01; 105(1):73-86.
PMID: 30797890.
Citations:
16 Fields:
Translation:
Humans
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Chadha AS, Gunther JR, Hsieh CE, Aliru M, Mahadevan LS, Venkatesulu BP, Crane CH, Das P, Herman JM, Koay EJ, Taniguchi C, Holliday EB, Minsky BD, Suh Y, Park P, Sawakuchi G, Beddar S, Odisio BC, Gupta S, Loyer E, Kaur H, Raghav K, Javle MM, Kaseb AO, Krishnan S. Proton beam therapy outcomes for localized unresectable hepatocellular carcinoma. Radiother Oncol. 2019 04; 133:54-61.
PMID: 30935582; PMCID: PMC6446916.
Citations:
17 Fields:
Translation:
Humans
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ShreeMahadevan L, Zhong J, Venkatesulu B, Kaur H, Bhide S, Minsky B, Chu W, Intven M, van der Heide UA, Triest B, Krishnan S, Hall W. Corrigendum to "Imaging predictors of treatment outcomes in rectal cancer: An overview" [Crit. Rev. Oncol./Hematol. 129, (September) (2018), 153-162]. Crit Rev Oncol Hematol. 2019 02; 134:71.
PMID: 30771876.
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Venkatesulu BP, Hsieh CE, Sanders KL, Krishnan S. Recent advances in radiation therapy of pancreatic cancer. F1000Res. 2018; 7.
PMID: 30613390; PMCID: PMC6305239.
Citations:
3 Fields:
Translation:
HumansAnimals
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Venkatesulu BP, Sanders KL, Hsieh CE, Kim BK, Krishnan S. Biomarkers of radiation-induced vascular injury. Cancer Rep (Hoboken). 2019 04; 2(2):e1152.
PMID: 32721134; PMCID: PMC7941417.
Citations:
3 Fields:
Translation:
HumansAnimalsPHPublic Health
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Venkatesulu BP, Mahadevan LS, Aliru ML, Yang X, Bodd MH, Singh PK, Yusuf SW, Abe JI, Krishnan S. Radiation-Induced Endothelial Vascular?Injury: A Review of Possible Mechanisms. JACC Basic Transl Sci. 2018 Aug; 3(4):563-572.
PMID: 30175280; PMCID: PMC6115704.
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Elganainy D, Holliday EB, Taniguchi CM, Smith GL, Shroff R, Javle M, Raghav K, Kaseb A, Aloia TA, Vauthey JN, Tzeng CD, Herman JM, Koong AC, Krishnan SX, Minsky BD, Crane CH, Das P, Koay EJ. Dose escalation of radiotherapy in unresectable extrahepatic cholangiocarcinoma. Cancer Med. 2018 10; 7(10):4880-4892.
PMID: 30152073; PMCID: PMC6198206.
Citations:
9 Fields:
Translation:
Humans
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Jensen G, Tao R, Eng C, Skibber JM, Rodriguez-Bigas M, Chang GJ, You YN, Bednarski BK, Minsky BD, Koay E, Taniguchi C, Krishnan S, Das P. Treatment of primary rectal adenocarcinoma after prior pelvic radiation: The role of hyperfractionated accelerated reirradiation. Adv Radiat Oncol. 2018 Oct-Dec; 3(4):595-600.
PMID: 30370360; PMCID: PMC6200883.
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Mahadevan LS, Zhong J, Venkatesulu B, Kaur H, Bhide S, Minsky B, Chu W, Intven M, van der Heide UA, van Triest B, Krishnan S, Hall WA. Imaging predictors of treatment outcomes in rectal cancer: An overview. Crit Rev Oncol Hematol. 2018 Sep; 129:153-162.
PMID: 30097234.
Citations:
6 Fields:
Translation:
Humans
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Holliday EB, Lester SC, Harmsen WS, Eng C, Haddock MG, Krishnan S, Das P, Hallemeier CL. Extended-Field Chemoradiation Therapy for Definitive Treatment of Anal Canal Squamous Cell Carcinoma Involving the Para-Aortic Lymph Nodes. Int J Radiat Oncol Biol Phys. 2018 09 01; 102(1):102-108.
PMID: 29907489.
Citations:
3 Fields:
Translation:
Humans
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Yan Y, Yang J, Beddar S, Ibbott G, Wen Z, Court LE, Hwang KP, Kadbi M, Krishnan S, Fuller CD, Frank SJ, Yang J, Balter P, Kudchadker RJ, Wang J. A methodology to investigate the impact of image distortions on the radiation dose when using magnetic resonance images for planning. Phys Med Biol. 2018 04 05; 63(8):085005.
PMID: 29528037; PMCID: PMC7796777.
Citations:
11 Fields:
Translation:
Humans
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Ko KA, Wang Y, Kotla S, Fujii Y, Vu HT, Venkatesulu BP, Thomas TN, Medina JL, Gi YJ, Hada M, Grande-Allen J, Patel ZS, Milgrom SA, Krishnan S, Fujiwara K, Abe JI. Developing a Reliable Mouse Model for Cancer Therapy-Induced Cardiovascular Toxicity in Cancer Patients and Survivors. Front Cardiovasc Med. 2018; 5:26.
PMID: 29675417; PMCID: PMC5896304.
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Vu HT, Kotla S, Ko KA, Fujii Y, Tao Y, Medina J, Thomas T, Hada M, Sood AK, Singh PK, Milgrom SA, Krishnan S, Fujiwara K, Le NT, Abe JI. Ionizing Radiation Induces Endothelial Inflammation and Apoptosis via p90RSK-Mediated ERK5 S496 Phosphorylation. Front Cardiovasc Med. 2018; 5:23.
PMID: 29594152; PMCID: PMC5861757.
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Fang P, Jiang W, Davuluri R, Xu C, Krishnan S, Mohan R, Koong AC, Hsu CC, Lin SH. High lymphocyte count during neoadjuvant chemoradiotherapy is associated with improved pathologic complete response in esophageal cancer. Radiother Oncol. 2018 09; 128(3):584-590.
PMID: 29530432.
Citations:
37 Fields:
Translation:
Humans
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Venkatesulu BP, Mallick S, Lin SH, Krishnan S. A systematic review of the influence of radiation-induced lymphopenia on survival outcomes in solid tumors. Crit Rev Oncol Hematol. 2018 Mar; 123:42-51.
PMID: 29482778.
Citations:
96 Fields:
Translation:
HumansPHPublic Health
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Aliru ML, Schoenhals JE, Venkatesulu BP, Anderson CC, Barsoumian HB, Younes AI, K Mahadevan LS, Soeung M, Aziz KE, Welsh JW, Krishnan S. Radiation therapy and immunotherapy: what is the optimal timing or sequencing? Immunotherapy. 2018 02 01; 10(4):299-316.
PMID: 29421979; PMCID: PMC5810851.
Citations:
23 Fields:
Translation:
HumansAnimals
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Amer AM, Zaid M, Chaudhury B, Elganainy D, Lee Y, Wilke CT, Cloyd J, Wang H, Maitra A, Wolff RA, Varadhachary G, Overman MJ, Lee JE, Fleming JB, Tzeng CW, Katz MH, Holliday EB, Krishnan S, Minsky BD, Herman JM, Taniguchi CM, Das P, Crane CH, Le O, Bhosale P, Tamm EP, Koay EJ. Imaging-based biomarkers: Changes in the tumor interface of pancreatic ductal adenocarcinoma on computed tomography scans indicate response to cytotoxic therapy. Cancer. 2018 04 15; 124(8):1701-1709.
PMID: 29370450; PMCID: PMC5891375.
Citations:
15 Fields:
Translation:
Humans
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Venkatesulu BP, Krishnan S. Radiosensitization by inhibiting DNA repair: Turning the spotlight on homologous recombination. Hepatology. 2018 02; 67(2):470-472.
PMID: 28921592; PMCID: PMC5882583.
Citations:
1 Fields:
Translation:
AnimalsCells
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Khoo AM, Cho SH, Reynoso FJ, Aliru M, Aziz K, Bodd M, Yang X, Ahmed MF, Yasar S, Manohar N, Cho J, Tailor R, Thames HD, Krishnan S. Radiosensitization of Prostate Cancers In Vitro and In Vivo to Erbium-filtered Orthovoltage X-rays Using Actively Targeted Gold Nanoparticles. Sci Rep. 2017 12 22; 7(1):18044.
PMID: 29273727; PMCID: PMC5741750.
Citations:
16 Fields:
Translation:
HumansAnimalsCells
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Shiraishi Y, Fang P, Xu C, Song J, Krishnan S, Koay EJ, Mehran RJ, Hofstetter WL, Blum-Murphy M, Ajani JA, Komaki R, Minsky B, Mohan R, Hsu CC, Hobbs BP, Lin SH. Severe lymphopenia during neoadjuvant chemoradiation for esophageal cancer: A propensity matched analysis of the relative risk of proton versus photon-based radiation therapy. Radiother Oncol. 2018 07; 128(1):154-160.
PMID: 29248170; PMCID: PMC5999560.
Citations:
51 Fields:
Translation:
HumansPHPublic Health
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Holliday EB, Hunt A, You YN, Chang GJ, Skibber JM, Rodriguez-Bigas MA, Bednarski BK, Eng C, Koay EJ, Minsky BD, Taniguchi C, Krishnan S, Herman JM, Das P. Short course radiation as a component of definitive multidisciplinary treatment for select patients with metastatic rectal adenocarcinoma. J Gastrointest Oncol. 2017 Dec; 8(6):990-997.
PMID: 29299359; PMCID: PMC5750175.
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Yusuf SW, Venkatesulu BP, Mahadevan LS, Krishnan S. Radiation-Induced Cardiovascular Disease: A Clinical Perspective. Front Cardiovasc Med. 2017; 4:66.
PMID: 29124057; PMCID: PMC5662579.
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Al-Shamsi HO, Abdel-Wahab R, Hassan MM, Shalaby AS, Dahbour I, Lacin S, Mahvash A, Odisio BC, Murthy R, Avritscher R, Abdelsalam ME, Rashid A, Vauthey JN, Aloia TA, Conrad C, Chun YS, Krishnan S, Das P, Koay EJ, Amin HM, Yao JC, Kaseb AO. Natural History of T1N0M0 Hepatocellular Carcinoma: Large-Scale Study in the United States. Oncology. 2017; 93(4):233-242.
PMID: 28683459; PMCID: PMC6743737.
Citations:
1 Fields:
Translation:
Humans
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Holliday EB, Tao R, Brownlee Z, Das P, Krishnan S, Taniguchi C, Minsky BD, Herman JM, Kaseb A, Raghav K, Conrad C, Vauthey JN, Aloia TA, Chun YS, Crane CH, Koay EJ. Definitive radiation therapy for hepatocellular carcinoma with portal vein tumor thrombus. Clin Transl Radiat Oncol. 2017 Jun; 4:39-45.
PMID: 29594206; PMCID: PMC5833919.
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Chadha AS, Suh Y, Krishnan S. In Reply to Yazici et?al. Int J Radiat Oncol Biol Phys. 2017 06 01; 98(2):485-486.
PMID: 28463175.
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You YN, Skibber JM, Rodriguez-Bigas MA, Das P, Eng C, Kopetz S, Wolff RA, Crane CH, Krishnan S, Minsky B, Hu CY, Nguyen S, Chang GJ, Park IJ. Oncologic and Functional Hazards of Obesity Among Patients With Locally Advanced Rectal Cancer Following Neoadjuvant Chemoradiation Therapy. Am J Clin Oncol. 2017 Jun; 40(3):277-282.
PMID: 27028350; PMCID: PMC5042800.
Citations:
5 Fields:
Translation:
Humans
-
Citations:
9 Fields:
Translation:
Animals
-
Tong Z, Chatterjee D, Deng D, Veeranki O, Mejia A, Ajani JA, Hofstetter W, Lin S, Guha S, Kopetz S, Krishnan S, Maru D. Antitumor effects of cyclin dependent kinase 9 inhibition in esophageal adenocarcinoma. Oncotarget. 2017 Apr 25; 8(17):28696-28710.
PMID: 28404924; PMCID: PMC5438684.
Citations:
8 Fields:
Translation:
HumansAnimalsCells
-
Gunther JR, Chadha AS, Shin US, Park IJ, Kattepogu KV, Grant JD, Weksberg DC, Eng C, Kopetz SE, Das P, Delclos ME, Kaur H, Maru DM, Skibber JM, Rodriguez-Bigas MA, You YN, Krishnan S, Chang GJ. Preoperative radiation dose escalation for rectal cancer using a concomitant boost strategy improves tumor downstaging without increasing toxicity: A matched-pair analysis. Adv Radiat Oncol. 2017 Jul-Sep; 2(3):455-464.
PMID: 29114614; PMCID: PMC5605486.
-
Citations:
7 Fields:
Translation:
Humans
-
Colbert LE, Moningi S, Chadha A, Amer A, Lee Y, Wolff RA, Varadhachary G, Fleming J, Katz M, Das P, Krishnan S, Koay EJ, Park P, Crane CH, Taniguchi CM. Dose escalation with an IMRT technique in 15 to 28 fractions is better tolerated than standard doses of 3DCRT for LAPC. Adv Radiat Oncol. 2017 Jul-Sep; 2(3):403-415.
PMID: 29114609; PMCID: PMC5605283.
-
Liu Q, Stewart J, Wang H, Rashid A, Zhao J, Katz MH, Lee JE, Fleming JB, Maitra A, Wolff RA, Varadhachary GR, Krishnan S, Wang H. Reduced expression of argininosuccinate synthetase 1 has a negative prognostic impact in patients with pancreatic ductal adenocarcinoma. PLoS One. 2017; 12(2):e0171985.
PMID: 28187218; PMCID: PMC5302782.
Citations:
11 Fields:
Translation:
Humans
-
Tao R, Tsai CJ, Jensen G, Eng C, Kopetz S, Overman MJ, Skibber JM, Rodriguez-Bigas M, Chang GJ, You YN, Bednarski BK, Minsky BD, Delclos ME, Koay E, Krishnan S, Crane CH, Das P. Hyperfractionated accelerated reirradiation for rectal cancer: An analysis of outcomes and toxicity. Radiother Oncol. 2017 01; 122(1):146-151.
PMID: 28057329.
Citations:
16 Fields:
Translation:
Humans
-
Chadha AS, Liu G, Chen HC, Das P, Minsky BD, Mahmood U, Delclos ME, Suh Y, Sawakuchi GO, Beddar S, Katz MH, Fleming JB, Javle MM, Varadhachary GR, Wolff RA, Crane CH, Wang X, Thames H, Krishnan S. Does Unintentional Splenic Radiation Predict Outcomes After Pancreatic Cancer Radiation Therapy? Int J Radiat Oncol Biol Phys. 2017 02 01; 97(2):323-332.
PMID: 28068240.
Citations:
37 Fields:
Translation:
Humans
-
Wang X, Schoenhals JE, Li A, Valdecanas DR, Ye H, Zang F, Tang C, Tang M, Liu CG, Liu X, Krishnan S, Allison JP, Sharma P, Hwu P, Komaki R, Overwijk WW, Gomez DR, Chang JY, Hahn SM, Cortez MA, Welsh JW. Suppression of Type I IFN Signaling in Tumors Mediates Resistance to Anti-PD-1 Treatment That Can Be Overcome by Radiotherapy. Cancer Res. 2017 02 15; 77(4):839-850.
PMID: 27821490; PMCID: PMC5875182.
Citations:
98 Fields:
Translation:
HumansAnimalsCells
-
Cloyd JM, Katz MH, Prakash L, Varadhachary GR, Wolff RA, Shroff RT, Javle M, Fogelman D, Overman M, Crane CH, Koay EJ, Das P, Krishnan S, Minsky BD, Lee JH, Bhutani MS, Weston B, Ross W, Bhosale P, Tamm EP, Wang H, Maitra A, Kim MP, Aloia TA, Vauthey JN, Fleming JB, Abbruzzese JL, Pisters PW, Evans DB, Lee JE. Preoperative Therapy and Pancreatoduodenectomy for Pancreatic Ductal Adenocarcinoma: a 25-Year Single-Institution Experience. J Gastrointest Surg. 2017 01; 21(1):164-174.
PMID: 27778257.
Citations:
38 Fields:
Translation:
Humans
-
Ohtsuka M, Ling H, Ivan C, Pichler M, Matsushita D, Goblirsch M, Stiegelbauer V, Shigeyasu K, Zhang X, Chen M, Vidhu F, Bartholomeusz GA, Toiyama Y, Kusunoki M, Doki Y, Mori M, Song S, Gunther JR, Krishnan S, Slaby O, Goel A, Ajani JA, Radovich M, Calin GA. H19 Noncoding RNA, an Independent Prognostic Factor, Regulates Essential Rb-E2F and CDK8-?-Catenin Signaling in Colorectal Cancer. EBioMedicine. 2016 Nov; 13:113-124.
PMID: 27789274; PMCID: PMC5264449.
Citations:
58 Fields:
Translation:
HumansAnimalsCells
-
Denbo JW, Bruno ML, Cloyd JM, Prakash L, Lee JE, Kim M, Crane CH, Koay EJ, Krishnan S, Das P, Minsky BD, Varadhachary G, Shroff R, Wolff R, Javle M, Overman MJ, Fogelman D, Aloia TA, Vauthey JN, Fleming JB, Katz MH. Preoperative Chemoradiation for Pancreatic Adenocarcinoma Does Not Increase 90-Day Postoperative Morbidity or Mortality. J Gastrointest Surg. 2016 12; 20(12):1975-1985.
PMID: 27730398.
Citations:
7 Fields:
Translation:
Humans
-
Javle M, Bekaii-Saab T, Jain A, Wang Y, Kelley RK, Wang K, Kang HC, Catenacci D, Ali S, Krishnan S, Ahn D, Bocobo AG, Zuo M, Kaseb A, Miller V, Stephens PJ, Meric-Bernstam F, Shroff R, Ross J. Biliary cancer: Utility of next-generation sequencing for clinical management. Cancer. 2016 Dec 15; 122(24):3838-3847.
PMID: 27622582.
Citations:
108 Fields:
Translation:
HumansCells
-
de Rosa N, Rodriguez-Bigas MA, Chang GJ, Veerapong J, Borras E, Krishnan S, Bednarski B, Messick CA, Skibber JM, Feig BW, Lynch PM, Vilar E, You YN. DNA Mismatch Repair Deficiency in Rectal Cancer: Benchmarking Its Impact on Prognosis, Neoadjuvant Response Prediction, and Clinical Cancer Genetics. J Clin Oncol. 2016 09 01; 34(25):3039-46.
PMID: 27432916; PMCID: PMC5012714.
Citations:
29 Fields:
Translation:
HumansCells
-
Ohri N, Dawson LA, Krishnan S, Seong J, Cheng JC, Sarin SK, Kinkhabwala M, Ahmed MM, Vikram B, Coleman CN, Guha C. Radiotherapy for Hepatocellular Carcinoma: New Indications and Directions for Future Study. J Natl Cancer Inst. 2016 09; 108(9).
PMID: 27377923; PMCID: PMC6279296.
Citations:
31 Fields:
Translation:
Humans
-
Chadha AS, Skinner HD, Gunther JR, Munsell MF, Das P, Minsky BD, Delclos ME, Chatterjee D, Wang H, Clemons M, George G, Singh PK, Katz MH, Fleming JB, Javle MM, Wolff RA, Varadhachary GR, Crane CH, Krishnan S. Phase I Trial of Consolidative Radiotherapy with Concurrent Bevacizumab, Erlotinib and Capecitabine for Unresectable Pancreatic Cancer. PLoS One. 2016; 11(6):e0156910.
PMID: 27336466; PMCID: PMC4919049.
Citations:
7 Fields:
Translation:
HumansCTClinical Trials
-
Cloyd JM, Crane CH, Koay EJ, Das P, Krishnan S, Prakash L, Snyder RA, Varadhachary GR, Wolff RA, Javle M, Shroff RT, Fogelman D, Overman M, Wang H, Maitra A, Lee JE, Fleming JB, Katz MH. Impact of hypofractionated and standard fractionated chemoradiation before pancreatoduodenectomy for pancreatic ductal adenocarcinoma. Cancer. 2016 09 01; 122(17):2671-9.
PMID: 27243381; PMCID: PMC4992463.
Citations:
14 Fields:
Translation:
Humans
-
Chadha AS, Khoo A, Aliru ML, Arora HK, Gunther JR, Krishnan S. Recent Advances and Prospects for Multimodality Therapy in Pancreatic Cancer. Semin Radiat Oncol. 2016 10; 26(4):320-37.
PMID: 27619253.
Citations:
12 Fields:
Translation:
Humans
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Bernstein MB, Krishnan S, Hodge JW, Chang JY. Immunotherapy and stereotactic ablative radiotherapy (ISABR): a curative approach? Nat Rev Clin Oncol. 2016 08; 13(8):516-24.
PMID: 26951040; PMCID: PMC6053911.
Citations:
137 Fields:
Translation:
Humans
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Cho J, Gonzalez-Lepera C, Manohar N, Kerr M, Krishnan S, Cho SH. Quantitative investigation of physical factors contributing to gold nanoparticle-mediated proton dose enhancement. Phys Med Biol. 2016 Mar 21; 61(6):2562-81.
PMID: 26952844.
Citations:
5 Fields:
Translation:
Animals
-
Wolfe T, Chatterjee D, Lee J, Grant JD, Bhattarai S, Tailor R, Goodrich G, Krishnan S, Nicolucci P. Corrigendum to "Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo" [Nanomedicine: Nanotechnology, Biology, and Medicine 11 (2015) 1277-1283]. Nanomedicine. 2016 Apr; 12(3):851-852.
PMID: 27018259.
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Meyn RE, Krishnan S, Skinner HD. Everything Old Is New Again: Using Nelfinavir to Radiosensitize Rectal Cancer. Clin Cancer Res. 2016 Apr 15; 22(8):1834-6.
PMID: 26920893; PMCID: PMC5061034.
Citations:
4 Fields:
Translation:
Humans
-
Manohar N, Reynoso FJ, Diagaradjane P, Krishnan S, Cho SH. Quantitative imaging of gold nanoparticle distribution in a tumor-bearing mouse using benchtop x-ray fluorescence computed tomography. Sci Rep. 2016 Feb 25; 6:22079.
PMID: 26912068; PMCID: PMC4766520.
Citations:
32 Fields:
Translation:
HumansAnimalsCells
-
Krishnan S, Chadha AS, Suh Y, Chen HC, Rao A, Das P, Minsky BD, Mahmood U, Delclos ME, Sawakuchi GO, Beddar S, Katz MH, Fleming JB, Javle MM, Varadhachary GR, Wolff RA, Crane CH. Focal Radiation Therapy Dose Escalation Improves Overall Survival in Locally Advanced Pancreatic Cancer Patients Receiving Induction Chemotherapy and Consolidative Chemoradiation. Int J Radiat Oncol Biol Phys. 2016 Mar 15; 94(4):755-65.
PMID: 26972648; PMCID: PMC4792191.
Citations:
119 Fields:
Translation:
Humans
-
Gunther J, Krishnan S. The evolving evidence for the efficacy and safety of charged particle therapy for hepatocellular carcinoma-a commentary. Ann Transl Med. 2015 Dec; 3(22):364.
PMID: 26807419; PMCID: PMC4701530.
Citations:
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Cortez MA, Ivan C, Valdecanas D, Wang X, Peltier HJ, Ye Y, Araujo L, Carbone DP, Shilo K, Giri DK, Kelnar K, Martin D, Komaki R, Gomez DR, Krishnan S, Calin GA, Bader AG, Welsh JW. PDL1 Regulation by p53 via miR-34. J Natl Cancer Inst. 2016 Jan; 108(1).
PMID: 26577528; PMCID: PMC4862407.
Citations:
246 Fields:
Translation:
AnimalsCells
-
Tao R, Krishnan S, Bhosale PR, Javle MM, Aloia TA, Shroff RT, Kaseb AO, Bishop AJ, Swanick CW, Koay EJ, Thames HD, Hong TS, Das P, Crane CH. Ablative Radiotherapy Doses Lead to a Substantial Prolongation of Survival in Patients With Inoperable Intrahepatic Cholangiocarcinoma: A Retrospective Dose Response Analysis. J Clin Oncol. 2016 Jan 20; 34(3):219-26.
PMID: 26503201; PMCID: PMC4980564.
Citations:
77 Fields:
Translation:
Humans
-
Singh PK, Krishnan S. Vitamin E Analogs as Radiation Response Modifiers. Evid Based Complement Alternat Med. 2015; 2015:741301.
PMID: 26366184; PMCID: PMC4558447.
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Grant JD, Jensen GL, Tang C, Pollard JM, Kry SF, Krishnan S, Dougherty AH, Gomez DR, Rozner MA. Radiotherapy-Induced Malfunction in Contemporary Cardiovascular Implantable Electronic Devices: Clinical Incidence and Predictors. JAMA Oncol. 2015 Aug; 1(5):624-32.
PMID: 26181143.
Citations:
18 Fields:
Translation:
Humans
-
Javle M, Churi C, Kang HC, Shroff R, Janku F, Surapaneni R, Zuo M, Barrera C, Alshamsi H, Krishnan S, Mishra L, Wolff RA, Kaseb AO, Thomas MB, Siegel AB. HER2/neu-directed therapy for biliary tract cancer. J Hematol Oncol. 2015 May 29; 8:58.
PMID: 26022204; PMCID: PMC4469402.
Citations:
77 Fields:
Translation:
Humans
-
Wolfe T, Chatterjee D, Lee J, Grant JD, Bhattarai S, Tailor R, Goodrich G, Krishnan S, Nicolucci P. Targeted gold nanoparticles enhance sensitization of prostate tumors to megavoltage radiation therapy in vivo. Nanomedicine. 2015 Jul; 11(5):1277-83.
PMID: 25652893; PMCID: PMC4476911.
Citations:
56 Fields:
Translation:
HumansAnimals
-
Deorukhkar A, Ahuja N, Mercado AL, Diagaradjane P, Raju U, Patel N, Mohindra P, Diep N, Guha S, Krishnan S. Zerumbone increases oxidative stress in a thiol-dependent ROS-independent manner to increase DNA damage and sensitize colorectal cancer cells to radiation. Cancer Med. 2015 Feb; 4(2):278-92.
PMID: 25450478; PMCID: PMC4329011.
Citations:
20 Fields:
Translation:
HumansCells
-
Abboud M, Eng C, Beddar AS, Krishnan S, Delclos ME, Crane CH, Das P, Mitchell MP. Intensity-modulated radiation therapy with concurrent chemotherapy for anal cancer: outcomes and toxicity. Am J Clin Oncol. 2014 Oct; 37(5):461-6.
PMID: 23466576.
Citations:
24 Fields:
Translation:
Humans
-
Tang C, Wang X, Soh H, Seyedin S, Cortez MA, Krishnan S, Massarelli E, Hong D, Naing A, Diab A, Gomez D, Ye H, Heymach J, Komaki R, Allison JP, Sharma P, Welsh JW. Combining radiation and immunotherapy: a new systemic therapy for solid tumors? Cancer Immunol Res. 2014 Sep; 2(9):831-8.
PMID: 25187273; PMCID: PMC5367158.
Citations:
132 Fields:
Translation:
HumansAnimals
-
Kaseb AO, Xiao L, Hassan MM, Chae YK, Lee JS, Vauthey JN, Krishnan S, Cheung S, Hassabo HM, Aloia T, Conrad C, Curley SA, Vierling JM, Jalal P, Raghav K, Wallace M, Rashid A, Abbruzzese JL, Wolff RA, Morris JS. Development and validation of insulin-like growth factor-1 score to assess hepatic reserve in hepatocellular carcinoma. J Natl Cancer Inst. 2014 May 09; 106(5).
PMID: 24815863; PMCID: PMC4085880.
Citations:
15 Fields:
Translation:
Humans
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Lee J, Chatterjee DK, Lee MH, Krishnan S. Gold nanoparticles in breast cancer treatment: promise and potential pitfalls. Cancer Lett. 2014 May 28; 347(1):46-53.
PMID: 24556077; PMCID: PMC4142062.
Citations:
54 Fields:
Translation:
Humans
-
Das P, Eng C, Rodriguez-Bigas MA, Chang GJ, Skibber JM, You YN, Maru DM, Munsell MF, Clemons MV, Kopetz SE, Garrett CR, Shureiqi I, Delclos ME, Krishnan S, Crane CH. Preoperative radiation therapy with concurrent capecitabine, bevacizumab, and erlotinib for rectal cancer: a phase 1 trial. Int J Radiat Oncol Biol Phys. 2014 Feb 01; 88(2):301-5.
PMID: 24315563; PMCID: PMC5592790.
Citations:
8 Fields:
Translation:
HumansCTClinical Trials
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Krishnan S, Ahmad M. Intensifying local radiotherapy for pancreatic cancer-who benefits and how do we select them? J Gastrointest Oncol. 2013 Dec; 4(4):337-9.
PMID: 24294503; PMCID: PMC3819774.
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Agarwal A, Chang GJ, Hu CY, Taggart M, Rashid A, Park IJ, You YN, Das P, Krishnan S, Crane CH, Rodriguez-Bigas M, Skibber J, Ellis L, Eng C, Kopetz S, Maru DM. Quantified pathologic response assessed as residual tumor burden is a predictor of recurrence-free survival in patients with rectal cancer who undergo resection after neoadjuvant chemoradiotherapy. Cancer. 2013 Dec 15; 119(24):4231-41.
PMID: 24089344; PMCID: PMC5897128.
Citations:
21 Fields:
Translation:
Humans
-
Chen W, Ayala-Orozco C, Biswal NC, Perez-Torres C, Bartels M, Bardhan R, Stinnet G, Liu XD, Ji B, Deorukhkar A, Brown LV, Guha S, Pautler RG, Krishnan S, Halas NJ, Joshi A. Targeting pancreatic cancer with magneto-fluorescent theranostic gold nanoshells. Nanomedicine (Lond). 2014; 9(8):1209-22.
PMID: 24063415; PMCID: PMC4051872.
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18 Fields:
Translation:
HumansAnimalsCells
-
Tzeng CW, Balachandran A, Ahmad M, Lee JE, Krishnan S, Wang H, Crane CH, Wolff RA, Varadhachary GR, Pisters PW, Aloia TA, Vauthey JN, Fleming JB, Katz MH. Serum carbohydrate antigen 19-9 represents a marker of response to neoadjuvant therapy in patients with borderline resectable pancreatic cancer. HPB (Oxford). 2014 May; 16(5):430-8.
PMID: 23991810; PMCID: PMC4008161.
Citations:
41 Fields:
Translation:
Humans
-
Lin SH, George TJ, Ben-Josef E, Bradley J, Choe KS, Edelman MJ, Guha C, Krishnan S, Lawrence TS, Le QT, Lu B, Mehta M, Peereboom D, Sarkaria J, Seong J, Wang D, Welliver MX, Coleman CN, Vikram B, Yoo S, Chung CH, Participants on Workshop for Preclinical and Clinical Development of Radiosensitizers, National Cancer Institute. Opportunities and challenges in the era of molecularly targeted agents and radiation therapy. J Natl Cancer Inst. 2013 May 15; 105(10):686-93.
PMID: 23503600; PMCID: PMC3733308.
Citations:
23 Fields:
Translation:
Humans
-
Skinner HD, Crane CH, Garrett CR, Eng C, Chang GJ, Skibber JM, Rodriguez-Bigas MA, Kelly P, Sandulache VC, Delclos ME, Krishnan S, Das P. Metformin use and improved response to therapy in rectal cancer. Cancer Med. 2013 Feb; 2(1):99-107.
PMID: 24133632; PMCID: PMC3797563.
Citations:
41 Fields:
Translation:
Humans
-
Das P, Abboud MT, Haque W, Javle M, Kaseb A, Curley SA, Vauthey JN, Aloia TA, Beddar AS, Delclos ME, Krishnan S, Crane CH. Gastric bleeding after radiation therapy for intrahepatic cholangiocarcinoma. Pract Radiat Oncol. 2013 Oct-Dec; 3(4):344-8.
PMID: 24674408.
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Kelly P, Das P, Pinnix CC, Beddar S, Briere T, Pham M, Krishnan S, Delclos ME, Crane CH. Duodenal toxicity after fractionated chemoradiation for unresectable pancreatic cancer. Int J Radiat Oncol Biol Phys. 2013 Mar 01; 85(3):e143-9.
PMID: 23200173.
Citations:
36 Fields:
Translation:
HumansPHPublic Health
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Briere TM, Crane CH, Beddar S, Bhosale P, Mok H, Delclos ME, Krishnan S, Das P. Reproducibility and genital sparing with a vaginal dilator used for female anal cancer patients. Radiother Oncol. 2012 Aug; 104(2):161-6.
PMID: 22841019.
Citations:
8 Fields:
Translation:
HumansPHPublic Health
-
Prasad S, Yadav VR, Sung B, Reuter S, Kannappan R, Deorukhkar A, Diagaradjane P, Wei C, Baladandayuthapani V, Krishnan S, Guha S, Aggarwal BB. Ursolic acid inhibits growth and metastasis of human colorectal cancer in an orthotopic nude mouse model by targeting multiple cell signaling pathways: chemosensitization with capecitabine. Clin Cancer Res. 2012 Sep 15; 18(18):4942-53.
PMID: 22832932; PMCID: PMC3677707.
Citations:
58 Fields:
Translation:
HumansAnimalsCells
-
Suzuki A, Xiao L, Taketa T, Blum MA, Matamoros A, Chien PL, Mansfield PF, Fournier KF, Weston B, Lee JH, Bhutani MS, Estrella JS, Delclos ME, Krishnan S, Das P, Ajani JA. Localized gastric cancer treated with chemoradation without surgery: UTMD Anderson Cancer Center experience. Oncology. 2012; 82(6):347-51.
PMID: 22677933.
Citations:
3 Fields:
Translation:
Humans
-
Park IJ, You YN, Agarwal A, Skibber JM, Rodriguez-Bigas MA, Eng C, Feig BW, Das P, Krishnan S, Crane CH, Hu CY, Chang GJ. Neoadjuvant treatment response as an early response indicator for patients with rectal cancer. J Clin Oncol. 2012 May 20; 30(15):1770-6.
PMID: 22493423; PMCID: PMC3383178.
Citations:
183 Fields:
Translation:
Humans
-
Wang XS, Williams LA, Krishnan S, Liao Z, Liu P, Mao L, Shi Q, Mobley GM, Woodruff JF, Cleeland CS. Serum sTNF-R1, IL-6, and the development of fatigue in patients with gastrointestinal cancer undergoing chemoradiation therapy. Brain Behav Immun. 2012 Jul; 26(5):699-705.
PMID: 22251605; PMCID: PMC3355215.
Citations:
53 Fields:
Translation:
Humans
-
Chakravarty T, Crane CH, Ajani JA, Mansfield PF, Briere TM, Beddar AS, Mok H, Reed VK, Krishnan S, Delclos ME, Das P. Intensity-modulated radiation therapy with concurrent chemotherapy as preoperative treatment for localized gastric adenocarcinoma. Int J Radiat Oncol Biol Phys. 2012 Jun 01; 83(2):581-6.
PMID: 22137021.
Citations:
17 Fields:
Translation:
Humans
-
Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets. Int J Cancer. 2012 Aug 01; 131(3):E292-303.
PMID: 21935918; PMCID: PMC3288649.
Citations:
17 Fields:
Translation:
HumansAnimalsCells
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Botros M, Chang K, Miller R, Krishnan S, Iott M. Recurrent invasive lobular carcinoma presenting as a ruptured breast implant. Radiol Oncol. 2012 Mar; 46(1):23-7.
PMID: 22933976; PMCID: PMC3423769.
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Skinner HD, Hong TS, Krishnan S. Charged-particle therapy for hepatocellular carcinoma. Semin Radiat Oncol. 2011 Oct; 21(4):278-86.
PMID: 21939857; PMCID: PMC3230301.
Citations:
18 Fields:
Translation:
Humans
-
Yadav VR, Prasad S, Sung B, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers. Int J Cancer. 2012 May 01; 130(9):2176-84.
PMID: 21702037; PMCID: PMC3246525.
Citations:
25 Fields:
Translation:
HumansAnimalsCells
-
Kaseb AO, Morris JS, Hassan MM, Siddiqui AM, Lin E, Xiao L, Abdalla EK, Vauthey JN, Aloia TA, Krishnan S, Abbruzzese JL. Clinical and prognostic implications of plasma insulin-like growth factor-1 and vascular endothelial growth factor in patients with hepatocellular carcinoma. J Clin Oncol. 2011 Oct 10; 29(29):3892-9.
PMID: 21911725; PMCID: PMC3189091.
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56 Fields:
Translation:
Humans
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Chatterjee DK, Diagaradjane P, Krishnan S. Nanoparticle-mediated hyperthermia in cancer therapy. Ther Deliv. 2011 Aug; 2(8):1001-14.
PMID: 22506095; PMCID: PMC3323111.
Citations:
82 Fields:
Translation:
Humans
-
Citations:
11 Fields:
Translation:
Humans
-
Crane CH, Varadhachary GR, Yordy JS, Staerkel GA, Javle MM, Safran H, Haque W, Hobbs BD, Krishnan S, Fleming JB, Das P, Lee JE, Abbruzzese JL, Wolff RA. Phase II trial of cetuximab, gemcitabine, and oxaliplatin followed by chemoradiation with cetuximab for locally advanced (T4) pancreatic adenocarcinoma: correlation of Smad4(Dpc4) immunostaining with pattern of disease progression. J Clin Oncol. 2011 Aug 01; 29(22):3037-43.
PMID: 21709185; PMCID: PMC3157965.
Citations:
109 Fields:
Translation:
HumansCTClinical Trials
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Citations:
1 Fields:
Translation:
Humans
-
Citations:
22 Fields:
Translation:
Humans
-
Deorukhkar A, Shentu S, Park HC, Diagaradjane P, Puduvalli V, Aggarwal B, Guha S, Krishnan S. Inhibition of radiation-induced DNA repair and prosurvival pathways contributes to vorinostat-mediated radiosensitization of pancreatic cancer cells. Pancreas. 2010 Nov; 39(8):1277-83.
PMID: 20531243; PMCID: PMC2955787.
Citations:
12 Fields:
Translation:
HumansCells
-
Atkinson RL, Zhang M, Diagaradjane P, Peddibhotla S, Contreras A, Hilsenbeck SG, Woodward WA, Krishnan S, Chang JC, Rosen JM. Thermal enhancement with optically activated gold nanoshells sensitizes breast cancer stem cells to radiation therapy. Sci Transl Med. 2010 Oct 27; 2(55):55ra79.
PMID: 20980696; PMCID: PMC4123313.
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65 Fields:
Translation:
HumansAnimalsCells
-
Kunnumakkara AB, Sung B, Ravindran J, Diagaradjane P, Deorukhkar A, Dey S, Koca C, Yadav VR, Tong Z, Gelovani JG, Guha S, Krishnan S, Aggarwal BB. {Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment. Cancer Res. 2010 Nov 01; 70(21):8695-705.
PMID: 20864511; PMCID: PMC2970705.
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49 Fields:
Translation:
HumansAnimalsCells
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Krishnan S, Diagaradjane P, Cho SH. Nanoparticle-mediated thermal therapy: evolving strategies for prostate cancer therapy. Int J Hyperthermia. 2010; 26(8):775-89.
PMID: 20858069; PMCID: PMC3071560.
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36 Fields:
Translation:
HumansAnimals
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Skinner HD, Krishnan S. Predicting, preventing, treating and understanding radiation nephropathy. J Gastrointest Oncol. 2010 Sep; 1(1):2-4.
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HumansAnimalsCells
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Crane CH, Eng C, Feig BW, Das P, Skibber JM, Chang GJ, Wolff RA, Krishnan S, Hamilton S, Janjan NA, Maru DM, Ellis LM, Rodriguez-Bigas MA. Phase II trial of neoadjuvant bevacizumab, capecitabine, and radiotherapy for locally advanced rectal cancer. Int J Radiat Oncol Biol Phys. 2010 Mar 01; 76(3):824-30.
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HumansCTClinical Trials
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Humans
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Park HC, Janjan NA, Mendoza TR, Lin EH, Vadhan-Raj S, Hundal M, Zhang Y, Delclos ME, Crane CH, Das P, Wang XS, Cleeland CS, Krishnan S. Temporal patterns of fatigue predict pathologic response in patients treated with preoperative chemoradiation therapy for rectal cancer. Int J Radiat Oncol Biol Phys. 2009 Nov 01; 75(3):775-81.
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HumansCTClinical Trials
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Herman MP, Kopetz S, Bhosale PR, Eng C, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Delclos ME, Krishnan S, Crane CH, Das P. Sacral insufficiency fractures after preoperative chemoradiation for rectal cancer: incidence, risk factors, and clinical course. Int J Radiat Oncol Biol Phys. 2009 Jul 01; 74(3):818-23.
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Humans
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Wang H, Krishnan S, Wang X, Beddar AS, Briere TM, Crane CH, Mohan R, Dong L. Improving soft-tissue contrast in four-dimensional computed tomography images of liver cancer patients using a deformable image registration method. Int J Radiat Oncol Biol Phys. 2008 Sep 01; 72(1):201-9.
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Humans
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Tong Z, Kunnumakkara AB, Wang H, Matsuo Y, Diagaradjane P, Harikumar KB, Ramachandran V, Sung B, Chakraborty A, Bresalier RS, Logsdon C, Aggarwal BB, Krishnan S, Guha S. Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer. Cancer Res. 2008 Aug 01; 68(15):6100-8.
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HumansCells
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Wagener M, Zhang X, Villarreal HG, Levy L, Allen P, Shentu S, Fang B, Krishnan S, Chang JY, Cheung MR. Effect of combining anti-epidermal growth factor receptor antibody C225 and radiation on DU145 prostate cancer. Oncol Rep. 2008 May; 19(5):1071-7.
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HumansAnimalsCells
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Krishnan S, Dawson LA, Seong J, Akine Y, Beddar S, Briere TM, Crane CH, Mornex F. Radiotherapy for hepatocellular carcinoma: an overview. Ann Surg Oncol. 2008 Apr; 15(4):1015-24.
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Humans
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26 Fields:
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Humans
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Reed VK, Krishnan S, Mansfield PF, Bhosale PR, Kim M, Das P, Janjan NA, Delclos ME, Lowy AM, Feig BW, Pisters PW, Ajani JA, Crane CH. Incidence, natural history, and patterns of locoregional recurrence in gastric cancer patients treated with preoperative chemoradiotherapy. Int J Radiat Oncol Biol Phys. 2008 Jul 01; 71(3):741-7.
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Humans
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Krishnan S, Briere TM, Dong L, Murthy R, Ng C, Balter P, Mohan R, Gillin MT, Beddar AS. Daily targeting of liver tumors: screening patients with a mock treatment and using a combination of internal and external fiducials for image-guided respiratory-gated radiotherapy. Med Phys. 2007 Dec; 34(12):4591-3.
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Humans
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Deorukhkar A, Krishnan S, Sethi G, Aggarwal BB. Back to basics: how natural products can provide the basis for new therapeutics. Expert Opin Investig Drugs. 2007 Nov; 16(11):1753-73.
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HumansAnimalsCells
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Krishnan S, Rana V, Janjan NA, Varadhachary GR, Abbruzzese JL, Das P, Delclos ME, Gould MS, Evans DB, Wolff RA, Crane CH. Induction chemotherapy selects patients with locally advanced, unresectable pancreatic cancer for optimal benefit from consolidative chemoradiation therapy. Cancer. 2007 Jul 01; 110(1):47-55.
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Humans
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Krishnan S, Rana V, Janjan NA, Abbruzzese JL, Gould MS, Das P, Delclos ME, Palla S, Guha S, Varadhachary G, Evans DB, Wolff RA, Crane CH. Prognostic factors in patients with unresectable locally advanced pancreatic adenocarcinoma treated with chemoradiation. Cancer. 2006 Dec 01; 107(11):2589-96.
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Humans
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Das P, Lin EH, Bhatia S, Skibber JM, Rodriguez-Bigas MA, Feig BW, Chang GJ, Hoff PM, Eng C, Wolff RA, Delclos ME, Krishnan S, Janjan NA, Crane CH. Preoperative chemoradiotherapy with capecitabine versus protracted infusion 5-fluorouracil for rectal cancer: a matched-pair analysis. Int J Radiat Oncol Biol Phys. 2006 Dec 01; 66(5):1378-83.
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Humans
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Krishnan S, Brown PD, Ballman KV, Fiveash JB, Uhm JH, Giannini C, Jaeckle KA, Geoffroy FJ, Nabors LB, Buckner JC, North Central Cancer Treatment Group. Phase I trial of erlotinib with radiation therapy in patients with glioblastoma multiforme: results of North Central Cancer Treatment Group protocol N0177. Int J Radiat Oncol Biol Phys. 2006 Jul 15; 65(4):1192-9.
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HumansCTClinical Trials
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Beddar AS, Krishnan S, Briere TM, Wang X, Delclos ME, Ballo MT, Das P, Gould S, Horton JL, Crane CH. The optimization of dose delivery for intraoperative high-dose-rate radiation therapy using curved HAM applicators. Radiother Oncol. 2006 Feb; 78(2):207-12.
PMID: 16376445.
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Humans
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Ahmad MS, Krishnan S, Ramakrishna BS, Mathan M, Pulimood AB, Murthy SN. Butyrate and glucose metabolism by colonocytes in experimental colitis in mice. Gut. 2000 Apr; 46(4):493-9.
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AnimalsCells
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Krishnan S, Ramakrishna BS, Keusch GT, Acheson DW, Pulimood AB, Mathan M. Effect of shiga toxin on NaCl transport in rat distal colon. Scand J Gastroenterol. 1999 Aug; 34(8):777-83.
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AnimalsCells
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Krishnan S, Rajan DP, Ramakrishna BS. The ability of enteric diarrhoeal pathogens to ferment starch to short-chain fatty acids in vitro. Scand J Gastroenterol. 1998 Mar; 33(3):242-6.
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HumansCells
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