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RAJESH R SINGH

TitleAssistant Professor
InstitutionMD Anderson
DepartmentHematopathology
Address6565 MD Anderson Blvd
Houston TX 77030
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Singh RR, Mehrotra M, Chen H, Almohammedsalim AA, Sahin A, Bosamra A, Patel KP, Routbort MJ, Lu X, Ronald A, Mishra BM, Virani S, Medeiros LJ, Luthra R. Comprehensive Screening of Gene Copy Number Aberrations in Formalin-Fixed, Paraffin-Embedded Solid Tumors Using Molecular Inversion Probe-Based Single-Nucleotide Polymorphism Array. J Mol Diagn. 2016 09; 18(5):676-687. PMID: 27392636.
      Citations: 8     Fields:    Translation:Humans
    2. Roy-Chowdhuri S, de Melo Gagliato D, Routbort MJ, Patel KP, Singh RR, Broaddus R, Lazar AJ, Sahin A, Alvarez RH, Moulder S, Wheler JJ, Janku F, Gonzalez-Angulo AM, Chavez-MacGregor M, Valero V, Ueno NT, Mills G, Mendelsohn J, Yao H, Aldape K, Luthra R, Meric-Bernstam F. Multigene clinical mutational profiling of breast carcinoma using next-generation sequencing. Am J Clin Pathol. 2015 Nov; 144(5):713-21. PMID: 26486734.
      Citations: 13     Fields:    Translation:Humans
    3. Mehrotra M, Luthra R, Singh RR, Barkoh BA, Galbincea J, Mehta P, Goswami RS, Jabbar KJ, Loghavi S, Medeiros LJ, Verstovsek S, Patel KP. Clinical validation of a multipurpose assay for detection and genotyping of CALR mutations in myeloproliferative neoplasms. Am J Clin Pathol. 2015 Nov; 144(5):746-55. PMID: 26486739.
      Citations: 3     Fields:    Translation:HumansCells
    4. Patel KP, Newberry KJ, Luthra R, Jabbour E, Pierce S, Cortes J, Singh R, Mehrotra M, Routbort MJ, Luthra M, Manshouri T, Santos FP, Kantarjian H, Verstovsek S. Correlation of mutation profile and response in patients with myelofibrosis treated with ruxolitinib. Blood. 2015 Aug 06; 126(6):790-7. PMID: 26124496; PMCID: PMC4528066.
      Citations: 74     Fields:    Translation:HumansCTClinical Trials
    5. Singh RR, Patel KP, Routbort MJ, Aldape K, Lu X, Manekia J, Abraham R, Reddy NG, Barkoh BA, Veliyathu J, Medeiros LJ, Luthra R. Clinical massively parallel next-generation sequencing analysis of 409 cancer-related genes for mutations and copy number variations in solid tumours. Br J Cancer. 2014 Nov 11; 111(10):2014-23. PMID: 25314059; PMCID: PMC4229640.
      Citations: 43     Fields:    Translation:Humans
    6. Loghavi S, Zuo Z, Ravandi F, Kantarjian HM, Bueso-Ramos C, Zhang L, Singh RR, Patel KP, Medeiros LJ, Stingo F, Routbort M, Cortes J, Luthra R, Khoury JD. Clinical features of de novo acute myeloid leukemia with concurrent DNMT3A, FLT3 and NPM1 mutations. J Hematol Oncol. 2014 Oct 04; 7:74. PMID: 25281355; PMCID: PMC4197326.
      Citations: 36     Fields:    Translation:Humans
    7. Luthra R, Patel KP, Reddy NG, Haghshenas V, Routbort MJ, Harmon MA, Barkoh BA, Kanagal-Shamanna R, Ravandi F, Cortes JE, Kantarjian HM, Medeiros LJ, Singh RR. Next-generation sequencing-based multigene mutational screening for acute myeloid leukemia using MiSeq: applicability for diagnostics and disease monitoring. Haematologica. 2014 Mar; 99(3):465-73. PMID: 24142997; PMCID: PMC3943309.
      Citations: 77     Fields:    Translation:Humans
    8. Kanagal-Shamanna R, Portier BP, Singh RR, Routbort MJ, Aldape KD, Handal BA, Rahimi H, Reddy NG, Barkoh BA, Mishra BM, Paladugu AV, Manekia JH, Kalhor N, Chowdhuri SR, Staerkel GA, Medeiros LJ, Luthra R, Patel KP. Next-generation sequencing-based multi-gene mutation profiling of solid tumors using fine needle aspiration samples: promises and challenges for routine clinical diagnostics. Mod Pathol. 2014 Feb; 27(2):314-27. PMID: 23907151.
      Citations: 58     Fields:    Translation:Humans
    9. Akama T, Virtucio C, Dong C, Kimura R, Zhang YK, Nieman JA, Sharma R, Lu X, Sales M, Singh R, Wu A, Fan XQ, Liu L, Plattner JJ, Jarnagin K, Freund YR. Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent. Bioorg Med Chem Lett. 2013 Mar 15; 23(6):1680-3. PMID: 23411072.
      Citations:    
    10. Ramirez E, Singh RR, Kunkalla K, Liu Y, Qu C, Cain C, Multani AS, Lennon PA, Jackacky J, Ho M, Dawud S, Gu J, Yang S, Hu PC, Vega F. Defining causative factors contributing in the activation of hedgehog signaling in diffuse large B-cell lymphoma. Leuk Res. 2012 Oct; 36(10):1267-73. PMID: 22809693; PMCID: PMC3422406.
      Citations: 2     Fields:    Translation:HumansCells
    11. Ok CY, Singh RR, Vega F. Aberrant activation of the hedgehog signaling pathway in malignant hematological neoplasms. Am J Pathol. 2012 Jan; 180(1):2-11. PMID: 22056910; PMCID: PMC3338341.
      Citations: 31     Fields:    Translation:HumansCells
    12. Singh RR, Kunkalla K, Qu C, Schlette E, Neelapu SS, Samaniego F, Vega F. ABCG2 is a direct transcriptional target of hedgehog signaling and involved in stroma-induced drug tolerance in diffuse large B-cell lymphoma. Oncogene. 2011 Dec 08; 30(49):4874-86. PMID: 21625222; PMCID: PMC3165099.
      Citations: 79     Fields:    Translation:HumansCells
    13. Greaves WO, Kim JE, Singh RR, Drakos E, Kunkalla K, Garcia JF, Medeiros LJ, Vega F, S?nchez-Espiridi?n B. Glioma-associated oncogene homologue 3, a hedgehog transcription factor, is highly expressed in Hodgkin and Reed-Sternberg cells of classical Hodgkin lymphoma. Hum Pathol. 2011 Nov; 42(11):1643-52. PMID: 21531006; PMCID: PMC3165071.
      Citations: 6     Fields:    Translation:HumansCells
    14. Drakos E, Singh RR, Rassidakis GZ, Schlette E, Li J, Claret FX, Ford RJ, Vega F, Medeiros LJ. Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21). Leukemia. 2011 May; 25(5):856-67. PMID: 21394100; PMCID: PMC3094765.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    15. Singh RR, Kim JE, Davuluri Y, Drakos E, Cho-Vega JH, Amin HM, Vega F. Hedgehog signaling pathway is activated in diffuse large B-cell lymphoma and contributes to tumor cell survival and proliferation. Leukemia. 2010 May; 24(5):1025-36. PMID: 20200556.
      Citations: 38     Fields:    Translation:HumansCells
    16. Vega F, Davuluri Y, Cho-Vega JH, Singh RR, Ma S, Wang RY, Multani AS, Drakos E, Pham LV, Lee YC, Shen L, Ambrus J, Medeiros LJ, Ford RJ. Side population of a murine mantle cell lymphoma model contains tumour-initiating cells responsible for lymphoma maintenance and dissemination. J Cell Mol Med. 2010 Jun; 14(6B):1532-45. PMID: 19656242; PMCID: PMC3829019.
      Citations: 9     Fields:    Translation:AnimalsCells
    17. Singh RR, Cho-Vega JH, Davuluri Y, Ma S, Kasbidi F, Milito C, Lennon PA, Drakos E, Medeiros LJ, Luthra R, Vega F. Sonic hedgehog signaling pathway is activated in ALK-positive anaplastic large cell lymphoma. Cancer Res. 2009 Mar 15; 69(6):2550-8. PMID: 19244133.
      Citations: 39     Fields:    Translation:HumansCells
    18. Luthra R, Singh RR, Luthra MG, Li YX, Hannah C, Romans AM, Barkoh BA, Chen SS, Ensor J, Maru DM, Broaddus RR, Rashid A, Albarracin CT. MicroRNA-196a targets annexin A1: a microRNA-mediated mechanism of annexin A1 downregulation in cancers. Oncogene. 2008 Nov 06; 27(52):6667-78. PMID: 18663355.
      Citations: 106     Fields:    Translation:HumansCells
    19. Molli PR, Singh RR, Lee SW, Kumar R. MTA1-mediated transcriptional repression of BRCA1 tumor suppressor gene. Oncogene. 2008 Mar 27; 27(14):1971-80. PMID: 17922032; PMCID: PMC2705285.
      Citations: 36     Fields:    Translation:HumansCells
    20. Singh RR, Kumar R. MTA family of transcriptional metaregulators in mammary gland morphogenesis and breast cancer. J Mammary Gland Biol Neoplasia. 2007 Sep; 12(2-3):115-25. PMID: 17549610.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    21. Acconcia F, Barnes CJ, Singh RR, Talukder AH, Kumar R. Phosphorylation-dependent regulation of nuclear localization and functions of integrin-linked kinase. Proc Natl Acad Sci U S A. 2007 Apr 17; 104(16):6782-7. PMID: 17420447; PMCID: PMC1871862.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    22. Singh RR, Kaluarachchi K, Chen M, Rayala SK, Balasenthil S, Ma J, Kumar R. Solution structure and antiestrogenic activity of the unique C-terminal, NR-box motif-containing region of MTA1s. J Biol Chem. 2006 Sep 01; 281(35):25612-21. PMID: 16807247.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    23. Gururaj AE, Singh RR, Rayala SK, Holm C, den Hollander P, Zhang H, Balasenthil S, Talukder AH, Landberg G, Kumar R. MTA1, a transcriptional activator of breast cancer amplified sequence 3. Proc Natl Acad Sci U S A. 2006 Apr 25; 103(17):6670-5. PMID: 16617102; PMCID: PMC1458939.
      Citations: 61     Fields:    Translation:HumansCells
    24. Singh RR, Gururaj AE, Vadlamudi RK, Kumar R. 9-cis-retinoic acid up-regulates expression of transcriptional coregulator PELP1, a novel coactivator of the retinoid X receptor alpha pathway. J Biol Chem. 2006 Jun 02; 281(22):15394-404. PMID: 16574651.
      Citations: 11     Fields:    Translation:HumansCells
    25. Singh RR, Barnes CJ, Talukder AH, Fuqua SA, Kumar R. Negative regulation of estrogen receptor alpha transactivation functions by LIM domain only 4 protein. Cancer Res. 2005 Nov 15; 65(22):10594-601. PMID: 16288053.
      Citations: 34     Fields:    Translation:HumansCells
    26. Singh RR, Kumar R. Steroid hormone receptor signaling in tumorigenesis. J Cell Biochem. 2005 Oct 15; 96(3):490-505. PMID: 16092128.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    27. Singh RR, Song C, Yang Z, Kumar R. Nuclear localization and chromatin targets of p21-activated kinase 1. J Biol Chem. 2005 May 06; 280(18):18130-7. PMID: 15749698.
      Citations: 42     Fields:    Translation:HumansCells
    28. Mishra SK, Talukder AH, Gururaj AE, Yang Z, Singh RR, Mahoney MG, Vadlamudi RK, Kumar R, Franc? C. Upstream determinants of estrogen receptor-alpha regulation of metastatic tumor antigen 3 pathway. J Biol Chem. 2004 Jul 30; 279(31):32709-15. PMID: 15169784; PMCID: PMC1262658.
      Citations: 26     Fields:    Translation:HumansCells
    29. Singh RR, Chang JY. Investigating conformational stability of bovine pancreatic phospholipase A2: a novel concept in evaluating the contribution of the 'native-framework' of disulphides to the global conformational stability of proteins. Biochem J. 2004 Feb 01; 377(Pt 3):685-92. PMID: 14533980; PMCID: PMC1223891.
      Citations: 6     Fields:    Translation:AnimalsCells
    30. Rajesh Singh R, Chang JY. Structural stability of human alpha-thrombin studied by disulfide reduction and scrambling. Biochim Biophys Acta. 2003 Sep 23; 1651(1-2):85-92. PMID: 14499592.
      Citations: 3     Fields:    Translation:HumansCells
    31. Singh RR, Appu Rao AG. Reductive unfolding and oxidative refolding of a Bowman-Birk inhibitor from horsegram seeds (Dolichos biflorus): evidence for "hyperreactive" disulfide bonds and rate-limiting nature of disulfide isomerization in folding. Biochim Biophys Acta. 2002 Jun 03; 1597(2):280-91. PMID: 12044906.
      Citations: 10     Fields:    Translation:AnimalsCells
    32. Single-cell quantitative PCR. 153-159.
    33. Analysis of pre-analytic factors affecting the success of clinical next-generation sequencing of solid organ malignancies. Cancers. 7:1699-1715.
    34. TP53 mutation characteristics in therapy-related myelodysplastic syndromes and acute myeloid leukemia is similar to de novo diseases. Journal of Hematology and Oncology. 8.
    35. Structural stability of human α-thrombin studied by disulfide reduction and scrambling. Biochimica et Biophysica Acta - Proteins and Proteomics. 1651:85-92.
    36. Myeloid neoplasms with isolated isochromosome 17q demonstrate a high frequency of mutations in SETBP1, SRSF2, ASXL1 and NRAS. Oncotarget. 7:14251-14258.
    37. Principles of analytical validation of next-generation sequencing based mutational analysis for hematologic neoplasms in a CLIA-certified laboratory. Expert Review of Molecular Diagnostics. 1-12.
    38. Identification of factors affecting the success of next-generation sequencing testing in solid tumors. American Journal of Clinical Pathology. 145:222-237.
    39. Intratumoral morphologic and molecular heterogeneity of rhabdoid renal cell carcinoma. Modern Pathology. 28:1225-1235.
    40. Genotyping of frequent mutations in solid tumors by pcrbased single-base extension and massarray analysis. 83-101.
    41. Erratum. Journal of Biological Chemistry. 288:27518.
    42. Validation and implementation of next-generation sequencing technologies in a clinical molecular diagnostic laboratory. 127-136.
    43. Journal of Molecular Diagnostics. 18:676-687.
    44. Hotspot mutation panel testing reveals clonal evolution in a study of 265 paired primary and metastatic tumors. Clinical Cancer Research. 21:2644-2651.
    45. Advances in clinical next-generation sequencing. Expert Review of Molecular Diagnostics. 16:357-372.
    46. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 110:4147-4148.
    47. Next-generation sequencing in clinical molecular diagnostics of cancer. Cancers. 7:2023-2036.
    48. Real-Time Genomic Characterization Utilizing Circulating Cell-Free DNA in Patients with Anaplastic Thyroid Carcinoma. Thyroid. 27:81-87.
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