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APAR PATAER

TitleAssociate Professor
InstitutionMD Anderson
DepartmentThoracic & Cardiovascular Surgery
Address1400 Pressler St
Houston TX 77030-4008
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhou N, Leung CH, William WN, Weissferdt A, Pataer A, Godoy MCB, Carter BW, Fossella FV, Tsao AS, Blumenschein GR, Le X, Zhang J, Skoulidis F, Kurie JM, Altan M, Lu C, Glisson BS, Byers LA, Elamin YY, Mehran RJ, Rice DC, Walsh GL, Hofstetter WL, Roth JA, Tran HT, Wu J, Solis Soto LM, Kadara H, Swisher SG, Vaporciyan AA, Gibbons DL, Lin HY, Lee JJ, Heymach JV, Negrao MV, Sepesi B, Cascone T. Impact of select actionable genomic alterations on efficacy of neoadjuvant immunotherapy in resectable non-small cell lung cancer. J Immunother Cancer. 2024 Oct 23; 12(10). PMID: 39448200; PMCID: PMC11499765.
      Citations:    Fields:    Translation:Humans
    2. Tan X, Wang S, Xiao GY, Wu C, Liu X, Zhou B, Yu J, Duose DY, Xi Y, Wang J, Gupta K, Pataer A, Roth JA, Kim MP, Chen F, Creighton CJ, Russell WK, Kurie JM. Chromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer. J Clin Invest. 2024 Apr 25. PMID: 38662435; PMCID: PMC11178546.
      Citations: 1     Fields:    
    3. Feldman H, Sepesi B, Leung CH, Lin H, Weissferdt A, Pataer A, William WN, Walsh GL, Rice DC, Roth JA, Mehran RJ, Hofstetter WL, Antonoff MB, Rajaram R, Gibbons DL, Lee JJ, Heymach JV, Vaporciyan AA, Swisher SG, Cascone T. Surgical outcomes after chemotherapy plus nivolumab and chemotherapy plus nivolumab and ipilimumab in patients with non-small cell lung cancer. J Thorac Cardiovasc Surg. 2024 Apr; 167(4):1444-1453.e4. PMID: 37816395.
      Citations:    Fields:    Translation:Humans
    4. Lv X, Lu X, Cao J, Luo Q, Ding Y, Peng F, Pataer A, Lu D, Han D, Malmberg E, Chan DW, Wang X, Savage SR, Mao S, Yu J, Peng F, Yan L, Meng H, Maneix L, Han Y, Chen Y, Yao W, Chang EC, Catic A, Lin X, Miles G, Huang P, Sun Z, Burt B, Wang H, Wang J, Yao QC, Zhang B, Roth JA, O'Malley BW, Ellis MJ, Rimawi MF, Ying H, Chen X. Modulation of the proteostasis network promotes tumor resistance to oncogenic KRAS inhibitors. Science. 2023 09 08; 381(6662):eabn4180. PMID: 37676964; PMCID: PMC10720158.
      Citations: 2     Fields:    Translation:HumansCells
    5. Cascone T, Leung CH, Weissferdt A, Pataer A, Carter BW, Godoy MCB, Feldman H, William WN, Xi Y, Basu S, Sun JJ, Yadav SS, Rojas Alvarez FR, Lee Y, Mishra AK, Chen L, Pradhan M, Guo H, Sinjab A, Zhou N, Negrao MV, Le X, Gay CM, Tsao AS, Byers LA, Altan M, Glisson BS, Fossella FV, Elamin YY, Blumenschein G, Zhang J, Skoulidis F, Wu J, Mehran RJ, Rice DC, Walsh GL, Hofstetter WL, Rajaram R, Antonoff MB, Fujimoto J, Solis LM, Parra ER, Haymaker C, Wistuba II, Swisher SG, Vaporciyan AA, Lin HY, Wang J, Gibbons DL, Jack Lee J, Ajami NJ, Wargo JA, Allison JP, Sharma P, Kadara H, Heymach JV, Sepesi B. Neoadjuvant chemotherapy plus nivolumab with or without ipilimumab in operable non-small cell lung cancer: the phase 2 platform NEOSTAR trial. Nat Med. 2023 03; 29(3):593-604. PMID: 36928818; PMCID: PMC10033402.
      Citations: 11     Fields:    Translation:HumansCTClinical Trials
    6. Pataer A, Weissferdt A, Correa AM, Vaporciyan AA, Sepesi B, Heymach JV, Berezowska S, Cascone T, Swisher SG. Major Pathologic Response and Prognostic Score Predict Survival in Patients With Lung Cancer Receiving Neoadjuvant Chemotherapy. JTO Clin Res Rep. 2022 Nov; 3(11):100420. PMID: 36389133; PMCID: PMC9646962.
      Citations:    
    7. Rocha P, Zhang J, Laza-Briviesca R, Bota-Rabassedas N, Sanchez-Espiridon B, Yoshimura K, Behrens C, Lu W, Tang X, Pataer A, Parra ER, Haymaker C, Fujimoto J, Swisher SG, Heymach JV, Gibbons DL, Lee JJ, Sepesi B, Cascone T, Solis LM, Provencio M, Wistuba II, Kadara H, Cruz-Berm?dez A. Distinct Immune Gene Programs Associated with Host Tumor Immunity, Neoadjuvant Chemotherapy, and Chemoimmunotherapy in Resectable NSCLC. Clin Cancer Res. 2022 06 01; 28(11):2461-2473. PMID: 35394499; PMCID: PMC9167789.
      Citations:    Fields:    Translation:HumansCells
    8. Zhang X, Zhang R, Ren C, Xu Y, Wu S, Meng C, Pataer A, Song X, Zhang J, Yao Y, He H, Chen H, Ma W, Wang J, Meric-Bernstam F, Champlin RE, Heymach JV, Rooney CM, Swisher SG, Vaporciyan AA, Roth JA, You MJ, Wang M, Fang B. Epstein Barr virus-positive B-cell lymphoma is highly vulnerable to MDM2 inhibitors in vivo. Blood Adv. 2022 02 08; 6(3):891-901. PMID: 34861697; PMCID: PMC8945299.
      Citations:    Fields:    Translation:HumansAnimalsCells
    9. Sepesi B, Zhou N, William WN, Lin HY, Leung CH, Weissferdt A, Mitchell KG, Pataer A, Walsh GL, Rice DC, Roth JA, Mehran RJ, Hofstetter WL, Antonoff MB, Rajaram R, Negrao MV, Tsao AS, Gibbons DL, Lee JJ, Heymach JV, Vaporciyan AA, Swisher SG, Cascone T. Surgical outcomes after neoadjuvant nivolumab or nivolumab with ipilimumab in patients with non-small cell lung cancer. J Thorac Cardiovasc Surg. 2022 11; 164(5):1327-1337. PMID: 35190177; PMCID: PMC10228712.
      Citations:    Fields:    
    10. Cascone T, Weissferdt A, Godoy MCB, William WN, Leung CH, Lin HY, Basu S, Yadav SS, Pataer A, Mitchell KG, Khan MAW, Shi Y, Haymaker C, Solis LM, Parra ER, Kadara H, Wistuba II, Sharma P, Allison JP, Ajami NJ, Wargo JA, Jenq RR, Gibbons DL, Lee JJ, Swisher SG, Vaporciyan AA, Heymach JV, Sepesi B. Nodal immune flare mimics nodal disease progression following neoadjuvant immune checkpoint inhibitors in non-small cell lung cancer. Nat Commun. 2021 08 19; 12(1):5045. PMID: 34413300; PMCID: PMC8376947.
      Citations: 8     Fields:    Translation:HumansCTClinical Trials
    11. Pataer A, Weissferdt A, Vaporciyan AA, Correa AM, Sepesi B, Wistuba II, Heymach JV, Cascone T, Swisher SG. Evaluation of Pathologic Response in Lymph Nodes of Patients With Lung Cancer Receiving Neoadjuvant Chemotherapy. J Thorac Oncol. 2021 08; 16(8):1289-1297. PMID: 33857666.
      Citations: 4     Fields:    Translation:Humans
    12. Cascone T, William WN, Weissferdt A, Leung CH, Lin HY, Pataer A, Godoy MCB, Carter BW, Federico L, Reuben A, Khan MAW, Dejima H, Francisco-Cruz A, Parra ER, Solis LM, Fujimoto J, Tran HT, Kalhor N, Fossella FV, Mott FE, Tsao AS, Blumenschein G, Le X, Zhang J, Skoulidis F, Kurie JM, Altan M, Lu C, Glisson BS, Byers LA, Elamin YY, Mehran RJ, Rice DC, Walsh GL, Hofstetter WL, Roth JA, Antonoff MB, Kadara H, Haymaker C, Bernatchez C, Ajami NJ, Jenq RR, Sharma P, Allison JP, Futreal A, Wargo JA, Wistuba II, Swisher SG, Lee JJ, Gibbons DL, Vaporciyan AA, Heymach JV, Sepesi B. Neoadjuvant nivolumab or nivolumab plus ipilimumab in operable non-small cell lung cancer: the phase 2 randomized NEOSTAR trial. Nat Med. 2021 03; 27(3):504-514. PMID: 33603241; PMCID: PMC8818318.
      Citations: 73     Fields:    Translation:HumansCTClinical Trials
    13. Weissferdt A, Pataer A, Swisher SG, Heymach JV, Gibbons DL, Cascone T, Sepesi B. Controversies and challenges in the pathologic examination of lung resection specimens after neoadjuvant treatment. Lung Cancer. 2021 04; 154:76-83. PMID: 33631448.
      Citations: 5     Fields:    Translation:Humans
    14. Corsini EM, Weissferdt A, Pataer A, Zhou N, Antonoff MB, Hofstetter WL, Mehran RJ, Rajaram R, Rice DC, Roth JA, Vaporciyan AA, Walsh GL, Cascone T, Heymach JV, Swisher SG, Sepesi B. Pathological nodal disease defines survival outcomes in patients with lung cancer with tumour major pathological response following neoadjuvant chemotherapy. Eur J Cardiothorac Surg. 2021 01 04; 59(1):100-108. PMID: 32864702.
      Citations: 8     Fields:    Translation:Humans
    15. Zhang X, Zhang R, Chen H, Wang L, Ren C, Pataer A, Wu S, Meng QH, Ha MJ, Morris J, Xi Y, Wang J, Zhang J, Gibbons DL, Heymach JV, Meric-Bernstam F, Minna J, Swisher SG, Roth JA, Fang B. KRT-232 and navitoclax enhance trametinib's anti-Cancer activity in non-small cell lung cancer patient-derived xenografts with KRAS mutations. Am J Cancer Res. 2020; 10(12):4464-4475. PMID: 33415011; PMCID: PMC7783771.
      Citations: 7     
    16. Weissferdt A, Pataer A, Vaporciyan AA, Correa AM, Sepesi B, Moran CA, Wistuba II, Roth JA, Shewale JB, Heymach JV, Kalhor N, Cascone T, Hofstetter WL, Lee JJ, Swisher SG. Agreement on Major Pathological Response in NSCLC Patients Receiving Neoadjuvant Chemotherapy. Clin Lung Cancer. 2020 07; 21(4):341-348. PMID: 32279936; PMCID: PMC7305995.
      Citations: 23     Fields:    Translation:Humans
    17. Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. 2020 01; 39(4):801-813. PMID: 31554935; PMCID: PMC6976521.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    18. Asik E, Caner A, Kahraman N, Guray T, Albarracin C, Pataer A, Ozpolat B, Akpinar Y, Volkan M, Arun B. EF2-kinase targeted cobalt-ferrite siRNA-nanotherapy suppresses BRCA1-mutated breast cancer. Nanomedicine (Lond). 2019 09; 14(17):2315-2338. PMID: 31432749.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    19. Chen Y, Zhang R, Wang L, Correa AM, Pataer A, Xu Y, Zhang X, Ren C, Wu S, Meng QH, Fujimoto J, Jensen VB, Antonoff MB, Hofstetter WL, Mehran RJ, Pisimisis G, Rice DC, Sepesi B, Vaporciyan AA, Walsh GL, Swisher SG, Roth JA, Heymach JV, Fang B. Tumor characteristics associated with engraftment of patient-derived non-small cell lung cancer xenografts in immunocompromised mice. Cancer. 2019 11 01; 125(21):3738-3748. PMID: 31287557; PMCID: PMC7294643.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    20. Baity M, Wang L, Correa AM, Zhang X, Zhang R, Pataer A, Wu S, Meng QH, Antonoff MB, Hofstetter WL, Mehran RJ, Rice DC, Roth JA, Sepesi B, Swisher SG, Vaporciyan AA, Walsh GL, Zhao M, Gu J, Fang B. Glutathione reductase (GSR) gene deletion and chromosome 8 aneuploidy in primary lung cancers detected by fluorescence in situ hybridization. Am J Cancer Res. 2019; 9(6):1201-1211. PMID: 31285952; PMCID: PMC6610060.
      Citations: 1     
    21. Pu X, Zhang R, Wang L, Chen Y, Xu Y, Pataer A, Meraz IM, Zhang X, Wu S, Wu L, Su D, Mao W, Heymach JV, Roth JA, Swisher SG, Fang B. Patient-derived tumor immune microenvironments in patient-derived xenografts of lung cancer. J Transl Med. 2018 11 26; 16(1):328. PMID: 30477533; PMCID: PMC6260563.
      Citations: 7     Fields:    Translation:HumansCells
    22. Bircan HA, Gurbuz N, Pataer A, Caner A, Kahraman N, Bayraktar E, Bayraktar R, Erdogan MA, Kabil N, Ozpolat B. Elongation factor-2 kinase (eEF-2K) expression is associated with poor patient survival and promotes proliferation, invasion and tumor growth of lung cancer. Lung Cancer. 2018 10; 124:31-39. PMID: 30268477.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    23. Parra ER, Villalobos P, Behrens C, Jiang M, Pataer A, Swisher SG, William WN, Zhang J, Lee J, Cascone T, Heymach JV, Haymaker C, Bernatchez C, Kalhor N, Weissferdt A, Moran C, Zhang J, Vaporciyan A, Gibbons DL, Sepesi B, Wistuba II, Forget MA. Effect of neoadjuvant chemotherapy on the immune microenvironment in non-small cell lung carcinomas as determined by multiplex immunofluorescence and image analysis approaches. J Immunother Cancer. 2018 06 06; 6(1):48. PMID: 29871672; PMCID: PMC5989476.
      Citations: 60     Fields:    Translation:Humans
    24. Pataer A, Shao R, Correa AM, Behrens C, Roth JA, Vaporciyan AA, Wistuba II, Swisher SG. Major pathologic response and RAD51 predict survival in lung cancer patients receiving neoadjuvant chemotherapy. Cancer Med. 2018 06; 7(6):2405-2414. PMID: 29673125; PMCID: PMC6010873.
      Citations: 9     Fields:    Translation:Humans
    25. Cascone T, Gold KA, Swisher SG, Liu DD, Fossella FV, Sepesi B, Pataer A, Weissferdt A, Kalhor N, Vaporciyan AA, Hofstetter WL, Wistuba II, Heymach JV, Kim ES, William WN. Induction Cisplatin Docetaxel Followed by Surgery and Erlotinib in Non-Small Cell Lung Cancer. Ann Thorac Surg. 2018 Feb; 105(2):418-424. PMID: 29217088; PMCID: PMC5783769.
      Citations: 12     Fields:    Translation:HumansCTClinical Trials
    26. Gentile E, Oba T, Lin J, Shao R, Meng F, Cao X, Lin HY, Mourad M, Pataer A, Baladandayuthapani V, Cai D, Roth JA, Ji L. Cationic liquid crystalline nanoparticles for the delivery of synthetic RNAi-based therapeutics. Oncotarget. 2017 Jul 18; 8(29):48222-48239. PMID: 28637023; PMCID: PMC5564640.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    27. Dalvi MP, Wang L, Zhong R, Kollipara RK, Park H, Bayo J, Yenerall P, Zhou Y, Timmons BC, Rodriguez-Canales J, Behrens C, Mino B, Villalobos P, Parra ER, Suraokar M, Pataer A, Swisher SG, Kalhor N, Bhanu NV, Garcia BA, Heymach JV, Coombes K, Xie Y, Girard L, Gazdar AF, Kittler R, Wistuba II, Minna JD, Martinez ED. Taxane-Platin-Resistant Lung Cancers Co-develop Hypersensitivity to JumonjiC Demethylase Inhibitors. Cell Rep. 2017 05 23; 19(8):1669-1684. PMID: 28538184; PMCID: PMC5531293.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    28. Hao C, Shao R, Raju U, Fang B, Swisher SG, Pataer A. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 2016 Jun 21; 7(25):38235-38242. PMID: 27203671; PMCID: PMC5122385.
      Citations: 3     Fields:    Translation:HumansCells
    29. Bozorov K, Zhao JY, Elmuradov B, Pataer A, Aisa HA. Recent developments regarding the use of thieno[2,3-d]pyrimidin-4-one derivatives in medicinal chemistry, with a focus on their synthesis and anticancer properties. Eur J Med Chem. 2015 Sep 18; 102:552-73. PMID: 26312434.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    30. Guo C, Hao C, Shao R, Fang B, Correa AM, Hofstetter WL, Roth JA, Behrens C, Kalhor N, Wistuba II, Swisher SG, Pataer A. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget. 2015 May 10; 6(13):11114-24. PMID: 25798539; PMCID: PMC4484443.
      Citations: 3     Fields:    Translation:HumansCells
    31. Hao C, Wang L, Peng S, Cao M, Li H, Hu J, Huang X, Liu W, Zhang H, Wu S, Pataer A, Heymach JV, Eterovic AK, Zhang Q, Shaw KR, Chen K, Futreal A, Wang M, Hofstetter W, Mehran R, Rice D, Roth JA, Sepesi B, Swisher SG, Vaporciyan A, Walsh GL, Johnson FM, Fang B. Gene mutations in primary tumors and corresponding patient-derived xenografts derived from non-small cell lung cancer. Cancer Lett. 2015 Feb 01; 357(1):179-185. PMID: 25444907; PMCID: PMC4301580.
      Citations: 52     Fields:    Translation:HumansAnimals
    32. Hellmann MD, Chaft JE, William WN, Rusch V, Pisters KM, Kalhor N, Pataer A, Travis WD, Swisher SG, Kris MG, University of Texas MD Anderson Lung Cancer Collaborative Group. Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers: proposal for the use of major pathological response as a surrogate endpoint. Lancet Oncol. 2014 Jan; 15(1):e42-50. PMID: 24384493; PMCID: PMC4734624.
      Citations: 133     Fields:    Translation:Humans
    33. Guo C, Lu H, Gao W, Wang L, Lu K, Wu S, Pataer A, Huang M, El-Zein R, Lin T, Roth JA, Mehran R, Hofstetter W, Swisher SG, Wu X, Fang B. Insulin-like growth factor binding protein-2 level is increased in blood of lung cancer patients and associated with poor survival. PLoS One. 2013; 8(9):e74973. PMID: 24069370; PMCID: PMC3775736.
      Citations: 20     Fields:    Translation:Humans
    34. Seurin D, Lombet A, Babajko S, Ricort JM, Godeau F. Insulin-like growth factor binding proteins increase intracellular calcium levels in two different cell lines. PLoS One. 2013; 8(3):e59323. PMID: 23527161; PMCID: PMC3602172.
      Citations: 6     Fields:    Translation:HumansCells
    35. Guo C, Shao R, Correa AM, Behrens C, Johnson FM, Raso MG, Prudkin L, Solis LM, Nunez MI, Fang B, Roth JA, Wistuba II, Swisher SG, Lin T, Pataer A. Prognostic significance of combinations of RNA-dependent protein kinase and EphA2 biomarkers for NSCLC. J Thorac Oncol. 2013 Mar; 8(3):301-8. PMID: 23370317; PMCID: PMC3573252.
      Citations: 12     Fields:    Translation:HumansCells
    36. William WN, Pataer A, Kalhor N, Correa AM, Rice DC, Wistuba II, Heymach J, Lee JJ, Kim ES, Munden R, Gold KA, Papadimitrakopoulou V, Swisher SG, Erasmus JJ, University of Texas M.D. Anderson Lung Cancer Collaborative Research Group. Computed tomography RECIST assessment of histopathologic response and prediction of survival in patients with resectable non-small-cell lung cancer after neoadjuvant chemotherapy. J Thorac Oncol. 2013 Feb; 8(2):222-8. PMID: 23287849; PMCID: PMC3549050.
      Citations: 40     Fields:    Translation:Humans
    37. Pataer A, Kalhor N, Correa AM, Raso MG, Erasmus JJ, Kim ES, Behrens C, Lee JJ, Roth JA, Stewart DJ, Vaporciyan AA, Wistuba II, Swisher SG, University of Texas M. D. Anderson Lung Cancer Collaborative Research Group. Histopathologic response criteria predict survival of patients with resected lung cancer after neoadjuvant chemotherapy. J Thorac Oncol. 2012 May; 7(5):825-32. PMID: 22481232; PMCID: PMC3465940.
      Citations: 109     Fields:    Translation:Humans
    38. He Y, Zhou Z, Hofstetter WL, Zhou Y, Hu W, Guo C, Wang L, Guo W, Pataer A, Correa AM, Lu Y, Wang J, Diao L, Byers LA, Wistuba II, Roth JA, Swisher SG, Heymach JV, Fang B. Aberrant expression of proteins involved in signal transduction and DNA repair pathways in lung cancer and their association with clinical parameters. PLoS One. 2012; 7(2):e31087. PMID: 22348039; PMCID: PMC3277494.
      Citations: 28     Fields:    Translation:HumansCells
    39. He Y, Correa AM, Raso MG, Hofstetter WL, Fang B, Behrens C, Roth JA, Zhou Y, Yu L, Wistuba II, Swisher SG, Pataer A. The role of PKR/eIF2a signaling pathway in prognosis of non-small cell lung cancer. PLoS One. 2011; 6(11):e24855. PMID: 22102852; PMCID: PMC3213082.
      Citations: 19     Fields:    Translation:HumansCells
    40. Pataer A, Raso MG, Correa AM, Behrens C, Tsuta K, Solis L, Fang B, Roth JA, Wistuba II, Swisher SG. Prognostic significance of RNA-dependent protein kinase on non-small cell lung cancer patients. Clin Cancer Res. 2010 Nov 15; 16(22):5522-8. PMID: 20930042; PMCID: PMC3070287.
      Citations: 13     Fields:    Translation:Humans
    41. Zhou Y, Hofstetter WL, He Y, Hu W, Pataer A, Wang L, Wang J, Zhou Y, Yu L, Fang B, Swisher SG. KLF4 inhibition of lung cancer cell invasion by suppression of SPARC expression. Cancer Biol Ther. 2010 Apr 01; 9(7):507-13. PMID: 20215880; PMCID: PMC2902679.
      Citations: 34     Fields:    Translation:HumansCells
    42. Hu W, Hofstetter WL, Li H, Zhou Y, He Y, Pataer A, Wang L, Xie K, Swisher SG, Fang B. Putative tumor-suppressive function of Kruppel-like factor 4 in primary lung carcinoma. Clin Cancer Res. 2009 Sep 15; 15(18):5688-95. PMID: 19737957; PMCID: PMC2745510.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    43. Fuson KL, Zheng M, Craxton M, Pataer A, Ramesh R, Chada S, Sutton RB. Structural mapping of post-translational modifications in human interleukin-24: role of N-linked glycosylation and disulfide bonds in secretion and activity. J Biol Chem. 2009 Oct 30; 284(44):30526-33. PMID: 19734147; PMCID: PMC2781607.
      Citations: 10     Fields:    Translation:HumansCells
    44. Pataer A, Swisher SG, Roth JA, Logothetis CJ, Corn PG. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biol Ther. 2009 Feb; 8(3):245-52. PMID: 19106640; PMCID: PMC2854203.
      Citations: 14     Fields:    Translation:HumansCells
    45. Hu W, Hofstetter W, Wei X, Guo W, Zhou Y, Pataer A, Li H, Fang B, Swisher SG. Double-stranded RNA-dependent protein kinase-dependent apoptosis induction by a novel small compound. J Pharmacol Exp Ther. 2009 Mar; 328(3):866-72. PMID: 19066342; PMCID: PMC2658620.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    46. Pataer A, Hu W, Xiaolin L, Chada S, Roth JA, Hunt KK, Swisher SG. Adenoviral endoplasmic reticulum-targeted mda-7/interleukin-24 vector enhances human cancer cell killing. Mol Cancer Ther. 2008 Aug; 7(8):2528-35. PMID: 18723497; PMCID: PMC2597048.
      Citations: 10     Fields:    Translation:AnimalsCells
    47. Hu W, Hofstetter W, Guo W, Li H, Pataer A, Peng HH, Guo ZS, Bartlett DL, Lin A, Swisher SG, Fang B. JNK-deficiency enhanced oncolytic vaccinia virus replication and blocked activation of double-stranded RNA-dependent protein kinase. Cancer Gene Ther. 2008 Sep; 15(9):616-24. PMID: 18535619; PMCID: PMC2553758.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    48. von Holzen U, Pataer A, Raju U, Bocangel D, Vorburger SA, Liu Y, Lu X, Roth JA, Aggarwal BB, Barber GN, Keyomarsi K, Hunt KK, Swisher SG. The double-stranded RNA-activated protein kinase mediates radiation resistance in mouse embryo fibroblasts through nuclear factor kappaB and Akt activation. Clin Cancer Res. 2007 Oct 15; 13(20):6032-9. PMID: 17947465.
      Citations: 12     Fields:    Translation:AnimalsCells
    49. Pataer A, Chada S, Roth JA, Hunt KK, Swisher SG. Development of Ad-mda7/IL-24-resistant lung cancer cell lines. Cancer Biol Ther. 2008 Jan; 7(1):103-8. PMID: 18059175; PMCID: PMC3442784.
      Citations: 2     Fields:    Translation:HumansCells
    50. Pataer A, Bocangel D, Chada S, Roth JA, Hunt KK, Swisher SG. Enhancement of adenoviral MDA-7-mediated cell killing in human lung cancer cells by geldanamycin and its 17-allyl- amino-17-demethoxy analogue. Cancer Gene Ther. 2007 Jan; 14(1):12-8. PMID: 17024233.
      Citations: 7     Fields:    Translation:HumansCells
    51. Takada Y, Ichikawa H, Pataer A, Swisher S, Aggarwal BB. Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation. Oncogene. 2007 Feb 22; 26(8):1201-12. PMID: 16924232.
      Citations: 41     Fields:    Translation:AnimalsCells
    52. Chada S, Mhashilkar AM, Liu Y, Nishikawa T, Bocangel D, Zheng M, Vorburger SA, Pataer A, Swisher SG, Ramesh R, Kawase K, Meyn RE, Hunt KK. mda-7 gene transfer sensitizes breast carcinoma cells to chemotherapy, biologic therapies and radiotherapy: correlation with expression of bcl-2 family members. Cancer Gene Ther. 2006 May; 13(5):490-502. PMID: 16282987.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    53. Pataer A, Fanale MA, Roth JA, Swisher SG, Hunt KK. Induction of apoptosis in human lung cancer cells following treatment with amifostine and an adenoviral vector containing wild-type p53. Cancer Gene Ther. 2006 Aug; 13(8):806-14. PMID: 16628227.
      Citations: 4     Fields:    Translation:HumansCells
    54. von Holzen U, Bocangel D, Pataer A, Vorburger SA, Liu Y, Lu X, Hunt KK, Swisher SG. Role for the double-stranded RNA-activated protein kinase PKR in Ad-TNF-alpha gene therapy in esophageal cancer. Surgery. 2005 Aug; 138(2):261-8. PMID: 16153435.
      Citations: 8     Fields:    Translation:HumansCells
    55. Pataer A, Vorburger SA, Chada S, Balachandran S, Barber GN, Roth JA, Hunt KK, Swisher SG. Melanoma differentiation-associated gene-7 protein physically associates with the double-stranded RNA-activated protein kinase PKR. Mol Ther. 2005 May; 11(5):717-23. PMID: 15851010.
      Citations: 33     Fields:    Translation:HumansAnimalsCells
    56. Sieger KA, Mhashilkar AM, Stewart A, Sutton RB, Strube RW, Chen SY, Pataer A, Swisher SG, Grimm EA, Ramesh R, Chada S. The tumor suppressor activity of MDA-7/IL-24 is mediated by intracellular protein expression in NSCLC cells. Mol Ther. 2004 Mar; 9(3):355-67. PMID: 15006602.
      Citations: 25     Fields:    Translation:HumansCells
    57. Vorburger SA, Pataer A, Swisher SG, Hunt KK. Genetically targeted cancer therapy: tumor destruction by PKR activation. Am J Pharmacogenomics. 2004; 4(3):189-98. PMID: 15174900.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    58. Pataer A, Chada S, Hunt KK, Roth JA, Swisher SG. Adenoviral melanoma differentiation-associated gene 7 induces apoptosis in lung cancer cells through mitochondrial permeability transition-independent cytochrome c release. J Thorac Cardiovasc Surg. 2003 Jun; 125(6):1328-35. PMID: 12830052.
      Citations: 1     Fields:    Translation:HumansCells
    59. Vorburger SA, Pataer A, Yoshida K, Liu Y, Lu X, Swisher SG, Hunt KK. The mitochondrial apoptosis-inducing factor plays a role in E2F-1-induced apoptosis in human colon cancer cells. Ann Surg Oncol. 2003 Apr; 10(3):314-22. PMID: 12679318.
      Citations: 6     Fields:    Translation:HumansCells
    60. Vorburger SA, Pataer A, Yoshida K, Barber GN, Xia W, Chiao P, Ellis LM, Hung MC, Swisher SG, Hunt KK. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene. 2002 Sep 12; 21(41):6278-88. PMID: 12214268.
      Citations: 12     Fields:    Translation:HumansCells
    61. Pataer A, Vorburger SA, Barber GN, Chada S, Mhashilkar AM, Zou-Yang H, Stewart AL, Balachandran S, Roth JA, Hunt KK, Swisher SG. Adenoviral transfer of the melanoma differentiation-associated gene 7 (mda7) induces apoptosis of lung cancer cells via up-regulation of the double-stranded RNA-dependent protein kinase (PKR). Cancer Res. 2002 Apr 15; 62(8):2239-43. PMID: 11956076.
      Citations: 36     Fields:    Translation:HumansCells
    62. Nutt LK, Chandra J, Pataer A, Fang B, Roth JA, Swisher SG, O'Neil RG, McConkey DJ. Bax-mediated Ca2+ mobilization promotes cytochrome c release during apoptosis. J Biol Chem. 2002 Jun 07; 277(23):20301-8. PMID: 11909872.
      Citations: 54     Fields:    Translation:HumansCells
    63. Nutt LK, Pataer A, Pahler J, Fang B, Roth J, McConkey DJ, Swisher SG. Bax and Bak promote apoptosis by modulating endoplasmic reticular and mitochondrial Ca2+ stores. J Biol Chem. 2002 Mar 15; 277(11):9219-25. PMID: 11741880.
      Citations: 77     Fields:    Translation:HumansCells
    64. Pataer A, Smythe WR, Yu R, Fang B, McDonnell T, Roth JA, Swisher SG. Adenovirus-mediated Bak gene transfer induces apoptosis in mesothelioma cell lines. J Thorac Cardiovasc Surg. 2001 Jan; 121(1):61-7. PMID: 11135160.
      Citations: 2     Fields:    Translation:HumansCells
    65. Hiai H, Abujiang P, Nishimura M. Polygenic resistance to mouse pulmonary adenomas. Exp Lung Res. 2000 Dec; 26(8):617-25. PMID: 11195459.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    66. Pataer A, Fang B, Yu R, Kagawa S, Hunt KK, McDonnell TJ, Roth JA, Swisher SG. Adenoviral Bak overexpression mediates caspase-dependent tumor killing. Cancer Res. 2000 Feb 15; 60(4):788-92. PMID: 10706081.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    67. Hiai H, Yamada Y, Abujiang P, Lu L, Kamoto T, Tsuruyama T. Genetic and epigenetic susceptibility to endogenous retrovirus-induced lymphomas in SL mice. Prog Exp Tumor Res. 1999; 35:64-77. PMID: 10377752.
      Citations: 3     Fields:    Translation:AnimalsCells
    68. Abujiang P, Mori TJ, Takahashi T, Tanaka F, Kasyu I, Hitomi S, Hiai H. Loss of heterozygosity (LOH) at 17q and 14q in human lung cancers. Oncogene. 1998 Dec 10; 17(23):3029-33. PMID: 9881705.
      Citations: 19     Fields:    Translation:HumansCells
    69. Pataer A, Nishimura M, Kamoto T, Ichioka K, Sato M, Hiai H. Genetic resistance to urethan-induced pulmonary adenomas in SMXA recombinant inbred mouse strains. Cancer Res. 1997 Jul 15; 57(14):2904-8. PMID: 9230199.
      Citations: 10     Fields:    Translation:Animals
    70. Lu LM, Ogawa M, Kamoto T, Yamada Y, Pataer A, Hiai H. Expression of LECAM-1 and LFA-1 on pre-B lymphoma cells but not on preneoplastic pre-B cells in SL/KH mice. Leuk Res. 1997 Apr; 21(4):337-42. PMID: 9150351.
      Citations: 4     Fields:    Translation:AnimalsCells
    71. Hiai H, Yamada Y, Shisa H, Kamoto T, Abujiang P, Lu LM. To be or not to be a T-lymphomas, that is determined by a dominant gene Tlsm-1 in mouse models. Leukemia. 1997 Apr; 11 Suppl 3:193-4. PMID: 9209340.
      Citations:    Fields:    Translation:AnimalsCells
    72. Matsushima Y, Kamoto T, Iida F, Abujiang P, Honda Y, Hiai H. Mapping of rupture of lens cataract (rlc) on mouse chromosome 14. Genomics. 1996 Sep 15; 36(3):553-4. PMID: 8884285.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    73. Pataer A, Kamoto T, Lu LM, Yamada Y, Hiai H. Two dominant host resistance genes to pre-B lymphoma in wild-derived inbred mouse strain MSM/Ms. Cancer Res. 1996 Aug 15; 56(16):3716-20. PMID: 8706013.
      Citations: 4     Fields:    Translation:AnimalsCells
    74. Abujiang P, Yamada Y, Haller O, Kobayashi H, Kamoto T, Lu LM, Ogawa M, Ishimoto A, Katoh H, Kanehira K, Ikegami S, Fukumoto M, Hiai H. The origin of SL family mice. Lab Anim Sci. 1996 Aug; 46(4):410-7. PMID: 8872992.
      Citations: 8     Fields:    Translation:AnimalsCells
    75. Kamoto T, Shisa H, Pataer A, Lu L, Yoshida O, Yamada Y, Hiai H. A quantitative trait locus in major histocompatibility complex determining latent period of mouse lymphomas. Jpn J Cancer Res. 1996 Apr; 87(4):401-4. PMID: 8641972; PMCID: PMC5921108.
      Citations: 3     Fields:    Translation:AnimalsCells
    76. Sawada M, Horiguchi Y, Abujiang P, Miyake N, Kitamura Y, Midorikawa O, Hiai H. Monoclonal antibodies to a zinc-binding protein of rat Paneth cells. J Histochem Cytochem. 1994 Apr; 42(4):467-72. PMID: 8126373.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    77. Pathological response after neoadjuvant chemotherapy in resectable non-small-cell lung cancers. The Lancet Oncology. 15.
    78. Accumulation of RNA-dependent protein kinase (PKR) in the nuclei of lung cancer cells mediates radiation resistance. Oncotarget. 7:38235-38242.
    79. RNA-dependent protein kinase (PKR) depletes nutrients, inducing phosphorylation of AMP-activated kinase in lung cancer. Oncotarget. 6:11114-11124.
    80. Inhibition of RNA-dependent protein kinase (PKR) leads to cancer cell death and increases chemosensitivity. Cancer Biology and Therapy. 8:241-248.
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