TitleAssistant Professor
InstitutionMD Anderson
DepartmentExperimental Therapeutics
Address1901 East Road
Houston TX 77054-3005
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Chen R, Tsai J, Thompson PA, Chen Y, Xiong P, Liu C, Burrows F, Sivina M, Burger JA, Keating MJ, Wierda WG, Plunkett W. The multi-kinase inhibitor TG02 induces apoptosis and blocks B-cell receptor signaling in chronic lymphocytic leukemia through dual mechanisms of action. Blood Cancer J. 2021 03 13; 11(3):57. PMID: 33714981; PMCID: PMC7956145.
      Citations: 4     Fields:    Translation:HumansCells
    2. Koay EJ, Baio FE, Ondari A, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Zhang J, Court L, Bhosale PR, Tamm EP, Qayyum A, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Maitra A, Ferrari M, Varadhachary GR, Fleming JB. Intra-tumoral heterogeneity of gemcitabine delivery and mass transport in human pancreatic cancer. Phys Biol. 2014 Nov 26; 11(6):065002. PMID: 25427073; PMCID: PMC4266401.
      Citations: 20     Fields:    Translation:Humans
    3. Koay EJ, Truty MJ, Cristini V, Thomas RM, Chen R, Chatterjee D, Kang Y, Bhosale PR, Tamm EP, Crane CH, Javle M, Katz MH, Gottumukkala VN, Rozner MA, Shen H, Lee JE, Wang H, Chen Y, Plunkett W, Abbruzzese JL, Wolff RA, Varadhachary GR, Ferrari M, Fleming JB. Transport properties of pancreatic cancer describe gemcitabine delivery and response. J Clin Invest. 2014 Apr; 124(4):1525-36. PMID: 24614108; PMCID: PMC3973100.
      Citations: 96     Fields:    Translation:HumansCTClinical Trials
    4. Liu H, Zhang T, Chen R, McConkey DJ, Ward JF, Curley SA. Multiple kinase pathways involved in the different de novo sensitivity of pancreatic cancer cell lines to 17-AAG. J Surg Res. 2012 Jul; 176(1):147-53. PMID: 22099584.
      Citations: 2     Fields:    Translation:HumansCells
    5. Carter BZ, Mak DH, Shi Y, Fidler JM, Chen R, Ling X, Plunkett W, Andreeff M. MRx102, a triptolide derivative, has potent antileukemic activity in vitro and in a murine model of AML. Leukemia. 2012 Mar; 26(3):443-50. PMID: 21904380; PMCID: PMC3598158.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    6. Zecevic A, Sampath D, Ewald B, Chen R, Wierda W, Plunkett W. Killing of chronic lymphocytic leukemia by the combination of fludarabine and oxaliplatin is dependent on the activity of XPF endonuclease. Clin Cancer Res. 2011 Jul 15; 17(14):4731-41. PMID: 21632856; PMCID: PMC5534342.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    7. Chen R, Guo L, Chen Y, Jiang Y, Wierda WG, Plunkett W. Homoharringtonine reduced Mcl-1 expression and induced apoptosis in chronic lymphocytic leukemia. Blood. 2011 Jan 06; 117(1):156-64. PMID: 20971952; PMCID: PMC3037741.
      Citations: 47     Fields:    Translation:HumansCells
    8. Chen R, Chubb S, Cheng T, Hawtin RE, Gandhi V, Plunkett W. Responses in mantle cell lymphoma cells to SNS-032 depend on the biological context of each cell line. Cancer Res. 2010 Aug 15; 70(16):6587-97. PMID: 20663900; PMCID: PMC2929954.
      Citations: 16     Fields:    Translation:HumansCells
    9. Tong WG, Chen R, Plunkett W, Siegel D, Sinha R, Harvey RD, Badros AZ, Popplewell L, Coutre S, Fox JA, Mahadocon K, Chen T, Kegley P, Hoch U, Wierda WG. Phase I and pharmacologic study of SNS-032, a potent and selective Cdk2, 7, and 9 inhibitor, in patients with advanced chronic lymphocytic leukemia and multiple myeloma. J Clin Oncol. 2010 Jun 20; 28(18):3015-22. PMID: 20479412; PMCID: PMC4979218.
      Citations: 85     Fields:    Translation:HumansCTClinical Trials
    10. Chen R, Plunkett W. Strategy to induce apoptosis and circumvent resistance in chronic lymphocytic leukaemia. Best Pract Res Clin Haematol. 2010 Mar; 23(1):155-66. PMID: 20620979.
      Citations: 8     Fields:    Translation:Humans
    11. Kurtova AV, Balakrishnan K, Chen R, Ding W, Schnabl S, Quiroga MP, Sivina M, Wierda WG, Estrov Z, Keating MJ, Shehata M, Gandhi V, Kay NE, Plunkett W, Burger JA, J?ger U. Diverse marrow stromal cells protect CLL cells from spontaneous and drug-induced apoptosis: development of a reliable and reproducible system to assess stromal cell adhesion-mediated drug resistance. Blood. 2009 Nov 12; 114(20):4441-50. PMID: 19762485; PMCID: PMC4081374.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    12. Chen R, Wierda WG, Chubb S, Hawtin RE, Fox JA, Keating MJ, Gandhi V, Plunkett W. Mechanism of action of SNS-032, a novel cyclin-dependent kinase inhibitor, in chronic lymphocytic leukemia. Blood. 2009 May 07; 113(19):4637-45. PMID: 19234140; PMCID: PMC2680368.
      Citations: 79     Fields:    Translation:HumansCells
    13. Qin T, Youssef EM, Jelinek J, Chen R, Yang AS, Garcia-Manero G, Issa JP. Effect of cytarabine and decitabine in combination in human leukemic cell lines. Clin Cancer Res. 2007 Jul 15; 13(14):4225-32. PMID: 17634552.
      Citations: 57     Fields:    Translation:HumansCells
    14. Chen R, Gandhi V, Plunkett W. A sequential blockade strategy for the design of combination therapies to overcome oncogene addiction in chronic myelogenous leukemia. Cancer Res. 2006 Nov 15; 66(22):10959-66. PMID: 17108134.
      Citations: 30     Fields:    Translation:HumansCells
    15. Chen R, Keating MJ, Gandhi V, Plunkett W. Transcription inhibition by flavopiridol: mechanism of chronic lymphocytic leukemia cell death. Blood. 2005 Oct 01; 106(7):2513-9. PMID: 15972445; PMCID: PMC1895272.
      Citations: 116     Fields:    Translation:HumansCells
    16. Chen R, Jonker JW, Nelson JA. Renal organic cation and nucleoside transport. Biochem Pharmacol. 2002 Jul 15; 64(2):185-90. PMID: 12123738.
      Citations: 2     Fields:    Translation:AnimalsCells
    17. Chen R, Nelson JA. Role of organic cation transporters in the renal secretion of nucleosides. Biochem Pharmacol. 2000 Jul 15; 60(2):215-9. PMID: 10825466.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    18. Chen R, Pan BF, Sakurai M, Nelson JA. A nucleoside-sensitive organic cation transporter in opossum kidney cells. Am J Physiol. 1999 02; 276(2):F323-8. PMID: 9950964.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    19. Pan BF, Sweet DH, Pritchard JB, Chen R, Nelson JA. A transfected cell model for the renal toxin transporter, rOCT2. Toxicol Sci. 1999 Feb; 47(2):181-6. PMID: 10220855.
      Citations: 10     Fields:    Translation:AnimalsCells
    20. Zhou Z, Zhu Z, Chen R, Liu C, Li X. High level expression of oryzacystatin in Escherichia coli. Chin J Biotechnol. 1996; 12(1):17-24. PMID: 8877110.
      Citations:    Fields:    Translation:AnimalsCells
    21. Derivatization of agelastatin A leading to bioactive analogs and a trifunctional probe. Bioorganic and Medicinal Chemistry Letters.
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