InstitutionMD Anderson
DepartmentSystems Biology
Address6565 MD Anderson Blvd
Houston TX 77030
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    R01CA251206     (LIN, SHIAW-YIH)Jul 1, 2021 - Jun 30, 2026
    RNase H2 is a novel therapeutic target in triple negative breast cancer
    Role: Principal Investigator

    R01CA247862     (LIN, SHIAW-YIH)Feb 1, 2021 - Jan 31, 2026
    Replication stress response defects predict and enhance immune checkpoint therapy response in triple negative breast cancer
    Role: Principal Investigator

    R01CA218287     (LIN, SHIAW-YIH)Aug 1, 2017 - Jul 31, 2022
    Signature-guided therapy for mismatch repair defective cancers
    Role: Principal Investigator

    R01CA172490     (LIN, SHIAW-YIH)Feb 1, 2013 - Jan 31, 2020
    Characterizing and Targeting CHD4 Deficiency in Endometrial Cancer
    Role: Principal Investigator

    R01CA120960     (LIN, SHIAW-YIH)Dec 5, 2006 - Sep 30, 2013
    Functional and Clinical Analysis of Rak in Breast Cancer Suppression
    Role: Principal Investigator

    R01CA112291     (LIN, SHIAW-YIH)Jun 1, 2005 - Apr 30, 2012
    BRIT 1: Roles in Immortalization, Checkpoints and Cancer
    Role: Principal Investigator

    F32CA093043     (LIN, SHIAW-YIH)Jan 1, 2002 - Dec 3, 2003
    Chk2--Roles in Checkpoint and Breast Tumor Suppression
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Zhao M, Wang T, Gleber-Netto FO, Chen Z, McGrail DJ, Gomez JA, Ju W, Gadhikar MA, Ma W, Shen L, Wang Q, Tang X, Pathak S, Raso MG, Burks JK, Lin SY, Wang J, Multani AS, Pickering CR, Chen J, Myers JN, Zhou G. Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response. Nat Commun. 2024 Jan 02; 15(1):180. PMID: 38167338; PMCID: PMC10761733.
      Citations: 1     Fields:    Translation:Humans
    2. McGrail DJ, Li Y, Smith RS, Feng B, Dai H, Hu L, Dennehey B, Awasthi S, Mendillo ML, Sood AK, Mills GB, Lin SY, Yi SS, Sahni N. Widespread BRCA1/2-independent homologous recombination defects are caused by alterations in RNA-binding proteins. Cell Rep Med. 2023 11 21; 4(11):101255. PMID: 37909041; PMCID: PMC10694618.
      Citations:    Fields:    Translation:Humans
    3. Siqueira JM, Mitani Y, Hoff CO, Bonini F, Guimaraes de Sousa L, Marques-Piubelli ML, Purushothaman A, Mitani M, Dai H, Lin SY, Spiotto MT, Hanna EY, McGrail DJ, El-Naggar AK, Ferrarotto R. Analysis of B7-H4 Expression Across Salivary Gland Carcinomas Reveals Adenoid Cystic Carcinoma-Specific Prognostic Relevance. Mod Pathol. 2024 Jan; 37(1):100371. PMID: 38015043.
      Citations: 1     Fields:    Translation:Humans
    4. Zhang J, Dai H, Huo L, Burks JK, McGrail DJ, Lin SY. Cytosolic DNA accumulation promotes breast cancer immunogenicity via a STING-independent pathway. J Immunother Cancer. 2023 10; 11(10). PMID: 37907220; PMCID: PMC10619126.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Sousa LG, McGrail DJ, Lazar Neto F, Li K, Marques-Piubelli ML, Ferri-Borgogno S, Dai H, Mitani Y, Spardy Burr N, Cooper ZA, Kinneer K, Cortez MA, Lin SY, Bell D, El Naggar A, Burks J, Ferrarotto R. Spatial Immunoprofiling of Adenoid Cystic Carcinoma Reveals B7-H4 Is a Therapeutic Target for Aggressive Tumors. Clin Cancer Res. 2023 08 15; 29(16):3162-3171. PMID: 37256648; PMCID: PMC10526680.
      Citations: 1     Fields:    Translation:Humans
    6. Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK. Correction: Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets. Clin Cancer Res. 2023 Jul 14; 29(14):2737. PMID: 37449360.
      Citations:    Fields:    
    7. Wang Y, Ma J, Lin SY, Xie H, Liang D. A stability indicating LC-MS/MS method for quantification of a NOX Inhibitor R14 in its bisulfite adduct form for pharmacokinetic studies. J Pharm Biomed Anal. 2023 May 10; 228:115326. PMID: 36924633; PMCID: PMC10079374.
      Citations:    Fields:    Translation:Animals
    8. Zhang J, Chan DW, Lin SY. Exploiting DNA Replication Stress as a Therapeutic Strategy for Breast Cancer. Biomedicines. 2022 Nov 01; 10(11). PMID: 36359297; PMCID: PMC9687274.
      Citations: 1     
    9. Tiwari A, Trivedi R, Lin SY. Tumor microenvironment: barrier or opportunity towards effective cancer therapy. J Biomed Sci. 2022 Oct 17; 29(1):83. PMID: 36253762; PMCID: PMC9575280.
      Citations: 23     Fields:    Translation:Humans
    10. Schmidt ST, Akhave N, Knightly RE, Reuben A, Vokes N, Zhang J, Li J, Fujimoto J, Byers LA, Sanchez-Espiridion B, Diao L, Wang J, Federico L, Forget MA, McGrail DJ, Weissferdt A, Lin SY, Lee Y, Suzuki E, Kovacs JJ, Behrens C, Wistuba II, Futreal A, Vaporciyan A, Sepesi B, Heymach JV, Bernatchez C, Haymaker C, Cascone T, Zhang J, Bristow CA, Heffernan TP, Negrao MV, Gibbons DL, ICON Team. Shared Nearest Neighbors Approach and Interactive Browser for Network Analysis of a Comprehensive Non-Small-Cell Lung Cancer Data Set. JCO Clin Cancer Inform. 2022 07; 6:e2200040. PMID: 35944232; PMCID: PMC9470146.
    11. Shih DJH, Li R, M?ller P, Zheng WJ, Do KA, Lin SY, Carter SL. CNGPLD: case-control copy-number analysis using Gaussian process latent difference. Bioinformatics. 2022 04 12; 38(8):2096-2101. PMID: 35176131; PMCID: PMC9004638.
      Citations:    Fields:    
    12. Sousa LG, McGrail DJ, Li K, Marques-Piubelli ML, Gonzalez C, Dai H, Ferri-Borgogno S, Godoy M, Burks J, Lin SY, Bell D, Ferrarotto R. Spontaneous tumor regression following COVID-19 vaccination. J Immunother Cancer. 2022 03; 10(3). PMID: 35241495; PMCID: PMC8896046.
      Citations:    Fields:    Translation:HumansCells
    13. Shah P, Frank ML, Jiang P, Sakellariou-Thompson D, Federico L, Khairullah R, Neutzler CA, Wistuba I, Chow CB, Long Y, Fujimoto J, Lin SY, Maitra A, Negrao MV, Mitchell KG, Weissferdt A, Vaporciyan AA, Cascone T, Roth JA, Zhang J, Sepesi B, Gibbons DL, Heymach JV, Haymaker CL, McGrail DJ, Reuben A, Bernatchez C, Forget MA. Combined IL-2, agonistic CD3 and 4-1BB stimulation preserve clonotype hierarchy in propagated non-small cell lung cancer tumor-infiltrating lymphocytes. J Immunother Cancer. 2022 02; 10(2). PMID: 35110355; PMCID: PMC8811607.
      Citations:    Fields:    Translation:HumansCells
    14. Shih DJH, Chen MK, Yin J, McGrail DJ, Dai H, Wei R, Zhang J, Zheng WJ, Do KA, Yang L, Hung MC, Lin SY. Exploiting induced vulnerability to overcome PARPi resistance and clonal heterogeneity in BRCA mutant triple-negative inflammatory breast cancer. Am J Cancer Res. 2022; 12(1):337-354. PMID: 35141022; PMCID: PMC8822293.
    15. McGrail DJ, Dai H, Lam TNA, Liang Y, Voorwerk L, Kok M, Zhang XH, Rosen JM, Heimberger AB, Peterson CB, Jonasch E, Lin SY, Pili? PG. Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers. Sci Transl Med. 2021 Oct 27; 13(617):eabe6201. PMID: 34705519; PMCID: PMC8577990.
      Citations: 2     Fields:    Translation:Humans
    16. Wei R, Dai H, Zhang J, Shih DJH, Liang Y, Xiao P, McGrail DJ, Lin SY. A Gene Expression Signature to Predict Nucleotide Excision Repair Defects and Novel Therapeutic Approaches. Int J Mol Sci. 2021 May 08; 22(9). PMID: 34066883; PMCID: PMC8125907.
      Citations:    Fields:    Translation:HumansCells
    17. Lindemann A, Patel AA, Tang L, Tanaka N, Gleber-Netto FO, Bartels MD, Wang L, McGrail DJ, Lin SY, Frank SJ, Frederick MJ, Myers JN, Osman AA. Combined Inhibition of Rad51 and Wee1 Enhances Cell Killing in HNSCC Through Induction of Apoptosis Associated With Excessive DNA Damage and Replication Stress. Mol Cancer Ther. 2021 07; 20(7):1257-1269. PMID: 33947685; PMCID: PMC8295235.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    18. Lin RA, Lin JK, Lin SY. Mechanisms of immunogenic cell death and immune checkpoint blockade therapy. Kaohsiung J Med Sci. 2021 Jun; 37(6):448-458. PMID: 33636043.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    19. Ferrarotto R, Mitani Y, McGrail DJ, Li K, Karpinets TV, Bell D, Frank SJ, Song X, Kupferman ME, Liu B, Lee JJ, Glisson BS, Zhang J, Aster JC, Lin SY, Futreal PA, Heymach JV, El-Naggar AK. Proteogenomic Analysis of Salivary Adenoid Cystic Carcinomas Defines Molecular Subtypes and Identifies Therapeutic Targets. Clin Cancer Res. 2021 02 01; 27(3):852-864. PMID: 33172898; PMCID: PMC7854509.
      Citations: 6     Fields:    Translation:HumansCells
    20. Zou J, Qin W, Yang L, Wang L, Wang Y, Shen J, Xiong W, Yu S, Song S, Ajani JA, Lin SY, Mills GB, Yuan X, Chen J, Peng G. Genetic alterations and expression characteristics of ARID1A impact tumor immune contexture and survival in early-onset gastric cancer. Am J Cancer Res. 2020; 10(11):3947-3972. PMID: 33294279; PMCID: PMC7716160.
      Citations: 4     
    21. Li Y, Burgman B, McGrail DJ, Sun M, Qi D, Shukla SA, Wu E, Capasso A, Lin SY, Wu CJ, Eckhardt SG, Mills GB, Li B, Sahni N, Yi SS. Integrated Genomic Characterization of the Human Immunome in Cancer. Cancer Res. 2020 11 01; 80(21):4854-4867. PMID: 32855206; PMCID: PMC7642109.
      Citations: 4     Fields:    Translation:HumansCells
    22. Zhang J, Shih DJH, Lin SY. Role of DNA repair defects in predicting immunotherapy response. Biomark Res. 2020; 8:23. PMID: 32612833; PMCID: PMC7325270.
      Citations: 19     
    23. Liang Y, Yu L, Zhang D, Zhao X, Gao H, Slagle BL, Goss JA, Wang X, Li K, Lin SY. BRIT1 dysfunction confers synergistic inhibition of hepatocellular carcinoma by targeting poly (ADP-ribose) polymerases and PI3K. Am J Cancer Res. 2020; 10(6):1900-1918. PMID: 32642299; PMCID: PMC7339272.
      Citations: 2     
    24. Liu XD, Kong W, Peterson CB, McGrail DJ, Hoang A, Zhang X, Lam T, Pilie PG, Zhu H, Beckermann KE, Haake SM, Isgandrova S, Martinez-Moczygemba M, Sahni N, Tannir NM, Lin SY, Rathmell WK, Jonasch E. PBRM1 loss defines a nonimmunogenic tumor phenotype associated with checkpoint inhibitor resistance in renal carcinoma. Nat Commun. 2020 05 01; 11(1):2135. PMID: 32358509; PMCID: PMC7195420.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    25. McGrail DJ, Garnett J, Yin J, Dai H, Shih DJH, Lam TNA, Li Y, Sun C, Li Y, Schmandt R, Wu JY, Hu L, Liang Y, Peng G, Jonasch E, Menter D, Yates MS, Kopetz S, Lu KH, Broaddus R, Mills GB, Sahni N, Lin SY. Proteome Instability Is a Therapeutic Vulnerability in Mismatch Repair-Deficient Cancer. Cancer Cell. 2020 03 16; 37(3):371-386.e12. PMID: 32109374; PMCID: PMC7337255.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    26. Wang J, McGrail DJ, Bhupal PK, Zhang W, Lin KY, Ku YH, Lin T, Wu H, Tsai KC, Li K, Peng CY, Finegold MJ, Lin SY, Tsai RYL. Nucleostemin Modulates Outcomes of Hepatocellular Carcinoma via a Tumor Adaptive Mechanism to Genomic Stress. Mol Cancer Res. 2020 05; 18(5):723-734. PMID: 32051231; PMCID: PMC7202947.
      Citations: 3     Fields:    Translation:Humans
    27. Park YY, Jung SY, Jennings NB, Rodriguez-Aguayo C, Peng G, Lee SR, Kim SB, Kim K, Leem SH, Lin SY, Lopez-Berestein G, Sood AK, Lee JS. Corrigendum: FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis. 2019 Jul 20; 40(7):936. PMID: 31063534; PMCID: PMC6642365.
      Citations: 1     Fields:    
    28. Zhang J, Shih DJH, Lin SY. The Tale of CHD4 in DNA Damage Response and Chemotherapeutic Response. J Cancer Res Cell Ther. 2019; 3(1). PMID: 32577620; PMCID: PMC7310990.
      Citations: 2     
    29. Fang Y, McGrail DJ, Sun C, Labrie M, Chen X, Zhang D, Ju Z, Vellano CP, Lu Y, Li Y, Jeong KJ, Ding Z, Liang J, Wang SW, Dai H, Lee S, Sahni N, Mercado-Uribe I, Kim TB, Chen K, Lin SY, Peng G, Westin SN, Liu J, O'Connor MJ, Yap TA, Mills GB. Sequential Therapy with PARP and WEE1 Inhibitors Minimizes Toxicity while Maintaining Efficacy. Cancer Cell. 2019 06 10; 35(6):851-867.e7. PMID: 31185210; PMCID: PMC6642675.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    30. Lin T, Lin TC, McGrail DJ, Bhupal PK, Ku YH, Zhang W, Meng L, Lin SY, Peng G, Tsai RYL. Nucleostemin reveals a dichotomous nature of genome maintenance in mammary tumor progression. Oncogene. 2019 05; 38(20):3919-3931. PMID: 30692636; PMCID: PMC6525051.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    31. Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Author Correction: Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol. 2018 Oct; 20(10):1226. PMID: 29632342.
      Citations: 2     Fields:    
    32. Jiang Y, Dai H, Li Y, Yin J, Guo S, Lin SY, McGrail DJ. PARP inhibitors synergize with gemcitabine by potentiating DNA damage in non-small-cell lung cancer. Int J Cancer. 2019 03 01; 144(5):1092-1103. PMID: 30152517; PMCID: PMC6320711.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    33. McGrail DJ, Lin CC, Dai H, Mo W, Li Y, Stephan C, Davies P, Lu Z, Mills GB, Lee JS, Lin SY. Defective Replication Stress Response Is Inherently Linked to the Cancer Stem Cell Phenotype. Cell Rep. 2018 05 15; 23(7):2095-2106. PMID: 29768207.
      Citations: 16     Fields:    Translation:HumansCells
    34. Li Y, Liu Q, McGrail DJ, Dai H, Li K, Lin SY. CHD4 mutations promote endometrial cancer stemness by activating TGF-beta signaling. Am J Cancer Res. 2018; 8(5):903-914. PMID: 29888111; PMCID: PMC5992509.
      Citations: 6     
    35. McGrail DJ, Federico L, Li Y, Dai H, Lu Y, Mills GB, Yi S, Lin SY, Sahni N. Multi-omics analysis reveals neoantigen-independent immune cell infiltration in copy-number driven cancers. Nat Commun. 2018 04 03; 9(1):1317. PMID: 29615613; PMCID: PMC5882811.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    36. Sun C, Yin J, Fang Y, Chen J, Jeong KJ, Chen X, Vellano CP, Ju Z, Zhao W, Zhang D, Lu Y, Meric-Bernstam F, Yap TA, Hattersley M, O'Connor MJ, Chen H, Fawell S, Lin SY, Peng G, Mills GB. BRD4 Inhibition Is Synthetic Lethal with PARP Inhibitors through the Induction of Homologous Recombination Deficiency. Cancer Cell. 2018 03 12; 33(3):401-416.e8. PMID: 29533782; PMCID: PMC5944839.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    37. Li Y, Sahni N, Pancsa R, McGrail DJ, Xu J, Hua X, Coulombe-Huntington J, Ryan M, Tychhon B, Sudhakar D, Hu L, Tyers M, Jiang X, Lin SY, Babu MM, Yi S. Revealing the Determinants of Widespread Alternative Splicing Perturbation in Cancer. Cell Rep. 2017 Oct 17; 21(3):798-812. PMID: 29045845; PMCID: PMC5689467.
      Citations: 23     Fields:    Translation:HumansCells
    38. Sun C, Fang Y, Yin J, Chen J, Ju Z, Zhang D, Chen X, Vellano CP, Jeong KJ, Ng PK, Eterovic AKB, Bhola NH, Lu Y, Westin SN, Grandis JR, Lin SY, Scott KL, Peng G, Brugge J, Mills GB. Rational combination therapy with PARP and MEK inhibitors capitalizes on therapeutic liabilities in RAS mutant cancers. Sci Transl Med. 2017 05 31; 9(392). PMID: 28566428; PMCID: PMC5919217.
      Citations: 80     Fields:    Translation:AnimalsCells
    39. Wang W, Zhao J, Wen X, Lin CC, Li J, Huang Q, Yu Y, Lin SY, Li C. MicroPET/CT Imaging of AXL Downregulation by HSP90 Inhibition in Triple-Negative Breast Cancer. Contrast Media Mol Imaging. 2017; 2017:1686525. PMID: 29097911; PMCID: PMC5612679.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    40. Federico L, Chong Z, Zhang D, McGrail DJ, Zhao W, Jeong KJ, Vellano CP, Ju Z, Gagea M, Liu S, Mitra S, Dennison JB, Lorenzi PL, Cardnell R, Diao L, Wang J, Lu Y, Byers LA, Perou CM, Lin SY, Mills GB. A murine preclinical syngeneic transplantation model for breast cancer precision medicine. Sci Adv. 2017 Apr; 3(4):e1600957. PMID: 28439535; PMCID: PMC5397135.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    41. McGrail DJ, Lin CC, Garnett J, Liu Q, Mo W, Dai H, Lu Y, Yu Q, Ju Z, Yin J, Vellano CP, Hennessy B, Mills GB, Lin SY. Improved prediction of PARP inhibitor response and identification of synergizing agents through use of a novel gene expression signature generation algorithm. NPJ Syst Biol Appl. 2017; 3:8. PMID: 28649435; PMCID: PMC5445594.
      Citations: 29     Fields:    
    42. Pan MR, Li K, Lin SY, Hung WC. Connecting the Dots: From DNA Damage and Repair to Aging. Int J Mol Sci. 2016 May 06; 17(5). PMID: 27164092; PMCID: PMC4881511.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    43. Mo W, Liu Q, Lin CC, Dai H, Peng Y, Liang Y, Peng G, Meric-Bernstam F, Mills GB, Li K, Lin SY. mTOR Inhibitors Suppress Homologous Recombination Repair and Synergize with PARP Inhibitors via Regulating SUV39H1 in BRCA-Proficient Triple-Negative Breast Cancer. Clin Cancer Res. 2016 Apr 01; 22(7):1699-712. PMID: 26546619; PMCID: PMC4858320.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    44. Kim JL, Ha GH, Campo L, Denning MF, Patel TB, Osipo C, Lin SY, Breuer EK. The role of Rak in the regulation of stability and function of BRCA1. Oncotarget. 2017 Oct 17; 8(49):86799-86815. PMID: 29156836; PMCID: PMC5689726.
      Citations: 6     Fields:    
    45. Evans EB, Lin SY. New insights into tumor dormancy: Targeting DNA repair pathways. World J Clin Oncol. 2015 Oct 10; 6(5):80-8. PMID: 26468441; PMCID: PMC4600194.
      Citations: 8     
    46. Jiang Y, Qian X, Shen J, Wang Y, Li X, Liu R, Xia Y, Chen Q, Peng G, Lin SY, Lu Z. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nat Cell Biol. 2015 Sep; 17(9):1158-68. PMID: 26237645; PMCID: PMC4800990.
      Citations: 81     Fields:    Translation:HumansCells
    47. Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, Hung MC. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res. 2015 Feb; 25(2):225-36. PMID: 25601159; PMCID: PMC4650576.
      Citations: 26     Fields:    Translation:HumansCells
    48. Gong L, Govan JM, Evans EB, Dai H, Wang E, Lee SW, Lin HK, Lazar AJ, Mills GB, Lin SY. Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure. Cell Cycle. 2015; 14(14):2323-32. PMID: 25946202; PMCID: PMC4614552.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    49. Peng Y, Dai H, Wang E, Lin CC, Mo W, Peng G, Lin SY. TUSC4 functions as a tumor suppressor by regulating BRCA1 stability. Cancer Res. 2015 Jan 15; 75(2):378-86. PMID: 25480944; PMCID: PMC4804342.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    50. Liang Y, Gao H, Lin SY, Goss JA, Du C, Li K. Mcph1/Brit1 deficiency promotes genomic instability and tumor formation in a mouse model. Oncogene. 2015 Aug 13; 34(33):4368-78. PMID: 25362854; PMCID: PMC4417661.
      Citations: 13     Fields:    Translation:AnimalsCells
    51. Peng G, Chun-Jen Lin C, Mo W, Dai H, Park YY, Kim SM, Peng Y, Mo Q, Siwko S, Hu R, Lee JS, Hennessy B, Hanash S, Mills GB, Lin SY. Genome-wide transcriptome profiling of homologous recombination DNA repair. Nat Commun. 2014; 5:3361. PMID: 24553445; PMCID: PMC4017859.
      Citations: 107     Fields:    Translation:HumansCells
    52. Wang SH, Lin SY. Tumor dormancy: potential therapeutic target in tumor recurrence and metastasis prevention. Exp Hematol Oncol. 2013 Oct 16; 2(1):29. PMID: 24502434; PMCID: PMC4176492.
      Citations: 22     
    53. Tian F, Sharma S, Zou J, Lin SY, Wang B, Rezvani K, Wang H, Parvin JD, Ludwig T, Canman CE, Zhang D. BRCA1 promotes the ubiquitination of PCNA and recruitment of translesion polymerases in response to replication blockade. Proc Natl Acad Sci U S A. 2013 Aug 13; 110(33):13558-63. PMID: 23901102; PMCID: PMC3746927.
      Citations: 25     Fields:    Translation:HumansCells
    54. Meng L, Lin T, Peng G, Hsu JK, Lee S, Lin SY, Tsai RY. Nucleostemin deletion reveals an essential mechanism that maintains the genomic stability of stem and progenitor cells. Proc Natl Acad Sci U S A. 2013 Jul 09; 110(28):11415-20. PMID: 23798389; PMCID: PMC3710807.
      Citations: 29     Fields:    Translation:AnimalsCells
    55. Hu R, Wang E, Peng G, Dai H, Lin SY. Zinc finger protein 668 interacts with Tip60 to promote H2AX acetylation after DNA damage. Cell Cycle. 2013 Jul 01; 12(13):2033-41. PMID: 23777805; PMCID: PMC3737306.
      Citations: 10     Fields:    Translation:HumansCells
    56. Zhang B, Wang E, Dai H, Hu R, Liang Y, Li K, Wang G, Peng G, Lin SY. BRIT1 regulates p53 stability and functions as a tumor suppressor in breast cancer. Carcinogenesis. 2013 Oct; 34(10):2271-80. PMID: 23729656; PMCID: PMC3786380.
      Citations: 10     Fields:    Translation:HumansCells
    57. Trinh BQ, Ko SY, Barengo N, Lin SY, Naora H. Dual functions of the homeoprotein DLX4 in modulating responsiveness of tumor cells to topoisomerase II-targeting drugs. Cancer Res. 2013 Jan 15; 73(2):1000-10. PMID: 23222298; PMCID: PMC3549009.
      Citations: 13     Fields:    Translation:HumansCells
    58. Park YY, Jung SY, Jennings NB, Rodriguez-Aguayo C, Peng G, Lee SR, Kim SB, Kim K, Leem SH, Lin SY, Lopez-Berestein G, Sood AK, Lee JS. FOXM1 mediates Dox resistance in breast cancer by enhancing DNA repair. Carcinogenesis. 2012 Oct; 33(10):1843-53. PMID: 22581827; PMCID: PMC3529559.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    59. Peng G, Dai H, Zhang W, Hsieh HJ, Pan MR, Park YY, Tsai RY, Bedrosian I, Lee JS, Ira G, Lin SY. Human nuclease/helicase DNA2 alleviates replication stress by promoting DNA end resection. Cancer Res. 2012 Jun 01; 72(11):2802-13. PMID: 22491672; PMCID: PMC3367086.
      Citations: 46     Fields:    Translation:HumansCells
    60. Pan MR, Hsieh HJ, Dai H, Hung WC, Li K, Peng G, Lin SY. Chromodomain helicase DNA-binding protein 4 (CHD4) regulates homologous recombination DNA repair, and its deficiency sensitizes cells to poly(ADP-ribose) polymerase (PARP) inhibitor treatment. J Biol Chem. 2012 Feb 24; 287(9):6764-72. PMID: 22219182; PMCID: PMC3307306.
      Citations: 43     Fields:    Translation:HumansCells
    61. Davis JD, Lin SY. DNA damage and breast cancer. World J Clin Oncol. 2011 Sep 10; 2(9):329-38. PMID: 21909479; PMCID: PMC3168783.
      Citations: 25     
    62. Zhang W, Peng G, Lin SY, Zhang P. DNA damage response is suppressed by the high cyclin-dependent kinase 1 activity in mitotic mammalian cells. J Biol Chem. 2011 Oct 14; 286(41):35899-35905. PMID: 21878640; PMCID: PMC3195557.
      Citations: 22     Fields:    Translation:HumansCells
    63. Hu R, Peng G, Dai H, Breuer EK, Stemke-Hale K, Li K, Gonzalez-Angulo AM, Mills GB, Lin SY. ZNF668 functions as a tumor suppressor by regulating p53 stability and function in breast cancer. Cancer Res. 2011 Oct 15; 71(20):6524-34. PMID: 21852383; PMCID: PMC3193577.
      Citations: 17     Fields:    Translation:HumansCells
    64. Pan MR, Peng G, Hung WC, Lin SY. Monoubiquitination of H2AX protein regulates DNA damage response signaling. J Biol Chem. 2011 Aug 12; 286(32):28599-607. PMID: 21676867; PMCID: PMC3151101.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    65. Peng G, Lin SY. Exploiting the homologous recombination DNA repair network for targeted cancer therapy. World J Clin Oncol. 2011 Feb 10; 2(2):73-9. PMID: 21603316; PMCID: PMC3095467.
      Citations: 16     
    66. Seviour EG, Lin SY. The DNA damage response: Balancing the scale between cancer and ageing. Aging (Albany NY). 2010 Dec; 2(12):900-7. PMID: 21191148; PMCID: PMC3034178.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    67. Liang Y, Gao H, Lin SY, Goss JA, Brunicardi FC, Li K. siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. PLoS One. 2010 Sep 20; 5(9):e12860. PMID: 20877462; PMCID: PMC2942895.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    68. Tian L, Peng G, Parant JM, Leventaki V, Drakos E, Zhang Q, Parker-Thornburg J, Shackleford TJ, Dai H, Lin SY, Lozano G, Rassidakis GZ, Claret FX. Essential roles of Jab1 in cell survival, spontaneous DNA damage and DNA repair. Oncogene. 2010 Nov 18; 29(46):6125-37. PMID: 20802511; PMCID: PMC3495558.
      Citations: 33     Fields:    Translation:AnimalsCells
    69. Lin SY, Liang Y, Li K. Multiple roles of BRIT1/MCPH1 in DNA damage response, DNA repair, and cancer suppression. Yonsei Med J. 2010 May; 51(3):295-301. PMID: 20376879; PMCID: PMC2852782.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    70. Liang Y, Gao H, Lin SY, Peng G, Huang X, Zhang P, Goss JA, Brunicardi FC, Multani AS, Chang S, Li K. BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice. PLoS Genet. 2010 Jan 22; 6(1):e1000826. PMID: 20107607; PMCID: PMC2809772.
      Citations: 57     Fields:    Translation:AnimalsCells
    71. Ishiguro T, Avila H, Lin SY, Nakamura T, Yamamoto M, Boyd DD. Gene trapping identifies chloride channel 4 as a novel inducer of colon cancer cell migration, invasion and metastases. Br J Cancer. 2010 Feb 16; 102(4):774-82. PMID: 20087350; PMCID: PMC2837579.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    72. Peng G, Lin SY. BRIT1/MCPH1 is a multifunctional DNA damage responsive protein mediating DNA repair-associated chromatin remodeling. Cell Cycle. 2009 Oct 01; 8(19):3071-2. PMID: 19755841; PMCID: PMC3419473.
      Citations: 8     Fields:    Translation:HumansCells
    73. Peng G, Lin SY. The linkage of chromatin remodeling to genome maintenance: contribution from a human disease gene BRIT1/MCPH1. Epigenetics. 2009 Oct 01; 4(7):457-61. PMID: 19829069; PMCID: PMC3419620.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    74. Yim EK, Siwko S, Lin SY. Exploring Rak tyrosine kinase function in breast cancer. Cell Cycle. 2009 Aug; 8(15):2360-4. PMID: 19597351.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    75. Peng G, Yim EK, Dai H, Jackson AP, Burgt Iv, Pan MR, Hu R, Li K, Lin SY. BRIT1/MCPH1 links chromatin remodelling to DNA damage response. Nat Cell Biol. 2009 Jul; 11(7):865-72. PMID: 19525936; PMCID: PMC2714531.
      Citations: 108     Fields:    Translation:HumansCells
    76. Yim EK, Peng G, Dai H, Hu R, Li K, Lu Y, Mills GB, Meric-Bernstam F, Hennessy BT, Craven RJ, Lin SY. Rak functions as a tumor suppressor by regulating PTEN protein stability and function. Cancer Cell. 2009 Apr 07; 15(4):304-14. PMID: 19345329; PMCID: PMC2673492.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    77. Liang Y, Lin SY, Brunicardi FC, Goss J, Li K. DNA damage response pathways in tumor suppression and cancer treatment. World J Surg. 2009 Apr; 33(4):661-6. PMID: 19034564.
      Citations: 41     Fields:    Translation:HumansCells
    78. Kim H, Lee OH, Xin H, Chen LY, Qin J, Chae HK, Lin SY, Safari A, Liu D, Songyang Z. TRF2 functions as a protein hub and regulates telomere maintenance by recognizing specific peptide motifs. Nat Struct Mol Biol. 2009 Apr; 16(4):372-9. PMID: 19287395.
      Citations: 70     Fields:    Translation:HumansCells
    79. Rai R, Phadnis A, Haralkar S, Badwe RA, Dai H, Li K, Lin SY. Differential regulation of centrosome integrity by DNA damage response proteins. Cell Cycle. 2008 Jul 15; 7(14):2225-33. PMID: 18635967; PMCID: PMC2557875.
      Citations: 31     Fields:    Translation:HumansCells
    80. Rai R, Peng G, Li K, Lin SY. DNA damage response: the players, the network and the role in tumor suppression. Cancer Genomics Proteomics. 2007 Mar-Apr; 4(2):99-106. PMID: 17804872.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    81. Chaplet M, Rai R, Jackson-Bernitsas D, Li K, Lin SY. BRIT1/MCPH1: a guardian of genome and an enemy of tumors. Cell Cycle. 2006 Nov; 5(22):2579-83. PMID: 17172830.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    82. Ding Z, Liang J, Lu Y, Yu Q, Songyang Z, Lin SY, Mills GB. A retrovirus-based protein complementation assay screen reveals functional AKT1-binding partners. Proc Natl Acad Sci U S A. 2006 Oct 10; 103(41):15014-9. PMID: 17018644; PMCID: PMC1636760.
      Citations: 46     Fields:    Translation:HumansCells
    83. Rai R, Dai H, Multani AS, Li K, Chin K, Gray J, Lahad JP, Liang J, Mills GB, Meric-Bernstam F, Lin SY. BRIT1 regulates early DNA damage response, chromosomal integrity, and cancer. Cancer Cell. 2006 Aug; 10(2):145-57. PMID: 16872911; PMCID: PMC1557410.
      Citations: 79     Fields:    Translation:HumansCells
    84. Lin SY, Rai R, Li K, Xu ZX, Elledge SJ. BRIT1/MCPH1 is a DNA damage responsive protein that regulates the Brca1-Chk1 pathway, implicating checkpoint dysfunction in microcephaly. Proc Natl Acad Sci U S A. 2005 Oct 18; 102(42):15105-9. PMID: 16217032; PMCID: PMC1257745.
      Citations: 82     Fields:    Translation:HumansCells
    85. Lin SY, Li K, Stewart GS, Elledge SJ. Human Claspin works with BRCA1 to both positively and negatively regulate cell proliferation. Proc Natl Acad Sci U S A. 2004 Apr 27; 101(17):6484-9. PMID: 15096610; PMCID: PMC404071.
      Citations: 59     Fields:    Translation:HumansCells
    86. Li K, Lin SY, Brunicardi FC, Seu P. Use of RNA interference to target cyclin E-overexpressing hepatocellular carcinoma. Cancer Res. 2003 Jul 01; 63(13):3593-7. PMID: 12839946.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    87. Lin SY, Elledge SJ. Multiple tumor suppressor pathways negatively regulate telomerase. Cell. 2003 Jun 27; 113(7):881-9. PMID: 12837246.
      Citations: 149     Fields:    Translation:HumansAnimalsCells
    88. Lin SY, Makino K, Xia W, Matin A, Wen Y, Kwong KY, Bourguignon L, Hung MC. Nuclear localization of EGF receptor and its potential new role as a transcription factor. Nat Cell Biol. 2001 Sep; 3(9):802-8. PMID: 11533659.
      Citations: 413     Fields:    Translation:HumansAnimalsCells
    89. Lin SY, Xia W, Wang JC, Kwong KY, Spohn B, Wen Y, Pestell RG, Hung MC. Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A. 2000 Apr 11; 97(8):4262-6. PMID: 10759547; PMCID: PMC18221.
      Citations: 332     Fields:    Translation:HumansCells
    90. Zhou BP, Hu MC, Miller SA, Yu Z, Xia W, Lin SY, Hung MC. HER-2/neu blocks tumor necrosis factor-induced apoptosis via the Akt/NF-kappaB pathway. J Biol Chem. 2000 Mar 17; 275(11):8027-31. PMID: 10713122.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    91. Wen Y, Yan DH, Spohn B, Deng J, Lin SY, Hung MC. Tumor suppression and sensitization to tumor necrosis factor alpha-induced apoptosis by an interferon-inducible protein, p202, in breast cancer cells. Cancer Res. 2000 Jan 01; 60(1):42-6. PMID: 10646849.
      Citations: 10     Fields:    Translation:HumansCells
    92. Shao R, Hu MC, Zhou BP, Lin SY, Chiao PJ, von Lindern RH, Spohn B, Hung MC. E1A sensitizes cells to tumor necrosis factor-induced apoptosis through inhibition of IkappaB kinases and nuclear factor kappaB activities. J Biol Chem. 1999 Jul 30; 274(31):21495-8. PMID: 10419449.
      Citations: 22     Fields:    Translation:HumansCells
    93. Black AR, Jensen D, Lin SY, Azizkhan JC. Growth/cell cycle regulation of Sp1 phosphorylation. J Biol Chem. 1999 Jan 15; 274(3):1207-15. PMID: 9880488.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    94. Kiyokawa N, Lee EK, Karunagaran D, Lin SY, Hung MC. Mitosis-specific negative regulation of epidermal growth factor receptor, triggered by a decrease in ligand binding and dimerization, can be overcome by overexpression of receptor. J Biol Chem. 1997 Jul 25; 272(30):18656-65. PMID: 9228035.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    95. Lin SY, Black AR, Kostic D, Pajovic S, Hoover CN, Azizkhan JC. Cell cycle-regulated association of E2F1 and Sp1 is related to their functional interaction. Mol Cell Biol. 1996 Apr; 16(4):1668-75. PMID: 8657142; PMCID: PMC231153.
      Citations: 71     Fields:    Translation:AnimalsCells
    96. Nuclear PTEN tumor-suppressor functions through maintaining heterochromatin structure. Cell Cycle. 14:2323-2332.
    97. Emerging roles of BRIT1/MCPH1 in genome maintenance and tumor suppression. 133-147.
    98. Cancer. Journal of Clinical Ligand Assay. 22:326-330.
    99. siRNA-based targeting of cyclin E overexpression inhibits breast cancer cell growth and suppresses tumor development in breast cancer mouse model. PLoS One. 5:1-10.
    100. Local generation of fumarate promotes DNA repair through inhibition of histone H3 demethylation. Nature Cell Biology. 17:1158-1168.
    101. Connecting the dots. International Journal of Molecular Sciences. 17.
    102. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Research. 25:225-236.
    103. mTOR inhibitors suppress homologous recombination repair and synergize with PARP inhibitors via regulating SUV39H1 in BRCA-proficient triple-negative breast cancer. Clinical Cancer Research. 22:1699-1712.
    104. New insights into tumor dormancy. World Journal of Clinical Oncology. 6:80-88.
    105. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 110:16283.
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