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SUBRATA SEN

TitleProfessor
InstitutionMD Anderson
DepartmentTranslational Molecular Pathology
Address2130 W Holcombe Blvd
Houston TX 77030
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    Collapse Bibliographic 
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Treekitkarnmongkol W, Solis LM, Sankaran D, Gagea M, Singh PK, Mistry R, Nguyen T, Kai K, Liu J, Sasai K, Jitsumori Y, Liu J, Nagao N, Stossi F, Mancini MA, Wistuba II, Thompson AM, Lee JM, Cadi?anos J, Wong KK, Abbott CM, Sahin AA, Liu S, Katayama H, Sen S. eEF1A2 promotes PTEN-GSK3?-SCF complex-dependent degradation of Aurora kinase A and is inactivated in breast cancer. Sci Signal. 2024 Mar 05; 17(826):eadh4475. PMID: 38442201.
      Citations:    Fields:    Translation:HumansAnimals
    2. Semaan A, Bernard V, Wong J, Makino Y, Swartzlander DB, Rajapakshe KI, Lee JJ, Officer A, Schmidt CM, Wu HH, Scaife CL, Affolter KE, Nachmanson D, Firpo MA, Yip-Schneider M, Lowy AM, Harismendy O, Sen S, Maitra A, Jakubek YA, Guerrero PA. Integrated Molecular Characterization of Intraductal Papillary Mucinous Neoplasms: An NCI Cancer Moonshot Precancer Atlas Pilot Project. Cancer Res Commun. 2023 10 10; 3(10):2062-2073. PMID: 37721516; PMCID: PMC10563795.
      Citations:    Translation:Humans
    3. Balasenthil S, Liu S, Dai J, Bamlet WR, Petersen G, Chari ST, Maitra A, Chen N, Sen S, McNeill Killary A. Blood-based Migration Signature Biomarker Panel Discriminates Early Stage New Onset Diabetes related Pancreatic Ductal Adenocarcinoma from Type 2 Diabetes. Clin Chim Acta. 2023 Nov 01; 551:117567. PMID: 37774897.
      Citations:    Fields:    Translation:Humans
    4. Purushothaman A, Oliva-Ram?rez J, Treekitkarnmongkol W, Sankaran D, Hurd MW, Putluri N, Maitra A, Haymaker C, Sen S. Differential Effects of Pancreatic Cancer-Derived Extracellular Vesicles Driving a Suppressive Environment. Int J Mol Sci. 2023 Sep 27; 24(19). PMID: 37834100; PMCID: PMC10572854.
      Citations:    Fields:    Translation:HumansCells
    5. Thaiparambil J, Amara CS, Sen S, Putluri N, El-Zein R. Cigarette smoke condensate induces centrosome clustering in normal lung epithelial cells. Cancer Med. 2023 04; 12(7):8499-8509. PMID: 36621828; PMCID: PMC10134322.
      Citations: 1     Fields:    Translation:HumansCells
    6. Hernandez S, Parra ER, Uraoka N, Tang X, Shen Y, Qiao W, Jiang M, Zhang S, Mino B, Lu W, Pandurengan R, Haymaker C, Affolter K, Scaife CL, Yip-Schneider M, Schmidt CM, Firpo MA, Mulvihill SJ, Koay EJ, Wang H, Wistuba II, Maitra A, Solis LM, Sen S. Diminished Immune Surveillance during Histologic Progression of Intraductal Papillary Mucinous Neoplasms Offers a Therapeutic Opportunity for Cancer Interception. Clin Cancer Res. 2022 05 02; 28(9):1938-1947. PMID: 35491652; PMCID: PMC9069801.
      Citations:    Fields:    Translation:Humans
    7. Chu Y, Pudakalakatti S, Hsieh KL, Salmon D, Dutta P, Millward NZ, Lurie E, Millward S, McAllister F, Maitra A, Sen S, Killary A, Zhang J, Jiang X, Bhattacharya PK, Shams S, Enriquez JS. Hyperpolarized Magnetic Resonance and Artificial Intelligence: Frontiers of Imaging in Pancreatic Cancer. JMIR Med Inform. 2021 Jun 17; 9(6):e26601. PMID: 34137725; PMCID: PMC8277399.
      Citations: 1     
    8. Dittmar RL, Liu S, Tai MC, Rajapakshe K, Huang Y, Longton G, DeCapite C, Hurd MW, Paris PL, Kirkwood KS, Coarfa C, Maitra A, Brand RE, Killary AM, Sen S. Plasma miRNA Biomarkers in Limited Volume Samples for Detection of Early-stage Pancreatic Cancer. Cancer Prev Res (Phila). 2021 07; 14(7):729-740. PMID: 33893071; PMCID: PMC8818322.
      Citations: 3     Fields:    Translation:Humans
    9. Kode J, Kovvuri J, Nagaraju B, Jadhav S, Barkume M, Sen S, Kasinathan NK, Chaudhari P, Mohanty BS, Gour J, Sigalapalli DK, Ganesh Kumar C, Pradhan T, Banerjee M, Kamal A. Synthesis, biological evaluation, and molecular docking analysis of phenstatin based indole linked chalcones as anticancer agents and tubulin polymerization inhibitors. Bioorg Chem. 2020 12; 105:104447. PMID: 33207276.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    10. Chen B, Dragomir MP, Fabris L, Bayraktar R, Liu X, Tang C, Li Y, Shimura T, Ivkovic TC, De Los Santos MC, Anfossi S, Shimizu M, Shah MY, Ling H, Shen P, Multani AS, Pardini B, Burks JK, Katayama H, Reineke LC, Huo L, Syed M, Song S, Ferracin M, Oki E, Fromm B, Ivan C, Bhuvaneshwar K, Gusev Y, Mimori K, Menter D, Sen S, Matsuyama T, Uetake H, Vasilescu C, Kopetz S, Parker-Thornburg J, Taguchi A, Hanash SM, Girnita L, Slaby O, Goel A, Varani G, Gagea M, Li C, Ajani JA, Calin GA, Knutsen E. The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling. Gastroenterology. 2020 12; 159(6):2146-2162.e33. PMID: 32805281; PMCID: PMC7725986.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    11. Dutta P, Pando SC, Mascaro M, Riquelme E, Zoltan M, Zacharias NM, Gammon ST, Piwnica-Worms D, Pagel MD, Sen S, Maitra A, Shams S, McAllister F, Bhattacharya PK. Early Detection of Pancreatic Intraepithelial Neoplasias (PanINs) in Transgenic Mouse Model by Hyperpolarized 13C Metabolic Magnetic Resonance Spectroscopy. Int J Mol Sci. 2020 May 25; 21(10). PMID: 32466260; PMCID: PMC7279395.
      Citations: 3     Fields:    Translation:Animals
    12. Dutta P, Perez MR, Lee J, Kang Y, Pratt M, Salzillo TC, Weygand J, Zacharias NM, Gammon ST, Koay EJ, Kim M, McAllister F, Sen S, Maitra A, Piwnica-Worms D, Fleming JB, Bhattacharya PK. Combining Hyperpolarized Real-Time Metabolic Imaging and NMR Spectroscopy To Identify Metabolic Biomarkers in Pancreatic Cancer. J Proteome Res. 2019 07 05; 18(7):2826-2834. PMID: 31120258.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    13. Jiao L, Maity S, Coarfa C, Rajapakshe K, Chen L, Jin F, Putluri V, Tinker LF, Mo Q, Chen F, Sen S, Sangi-Hyghpeykar H, El-Serag HB, Putluri N. A Prospective Targeted Serum Metabolomics Study of Pancreatic Cancer in Postmenopausal Women. Cancer Prev Res (Phila). 2019 04; 12(4):237-246. PMID: 30723176; PMCID: PMC6445762.
      Citations: 11     Fields:    Translation:Humans
    14. Bernard V, Semaan A, Huang J, San Lucas FA, Mulu FC, Stephens BM, Guerrero PA, Huang Y, Zhao J, Kamyabi N, Sen S, Scheet PA, Taniguchi CM, Kim MP, Tzeng CW, Katz MH, Singhi AD, Maitra A, Alvarez HA. Single-Cell Transcriptomics of Pancreatic Cancer Precursors Demonstrates Epithelial and Microenvironmental Heterogeneity as an Early Event in Neoplastic Progression. Clin Cancer Res. 2019 Apr 01; 25(7):2194-2205. PMID: 30385653; PMCID: PMC6445737.
      Citations: 111     Fields:    Translation:Humans
    15. Barua S, Solis L, Parra ER, Uraoka N, Jiang M, Wang H, Rodriguez-Canales J, Wistuba I, Maitra A, Sen S, Rao A. A Functional Spatial Analysis Platform for Discovery of Immunological Interactions Predictive of Low-Grade to High-Grade Transition of Pancreatic Intraductal Papillary Mucinous Neoplasms. Cancer Inform. 2018; 17:1176935118782880. PMID: 30013304; PMCID: PMC6043922.
      Citations: 16     
    16. Kai K, Iwamoto T, Zhang D, Shen L, Takahashi Y, Rao A, Thompson A, Sen S, Ueno NT. CSF-1/CSF-1R axis is associated with epithelial/mesenchymal hybrid phenotype in epithelial-like inflammatory breast cancer. Sci Rep. 2018 06 21; 8(1):9427. PMID: 29930294; PMCID: PMC6013474.
      Citations: 11     Fields:    Translation:HumansCells
    17. Kai K, Dittmar RL, Sen S. Secretory microRNAs as biomarkers of cancer. Semin Cell Dev Biol. 2018 06; 78:22-36. PMID: 29258963.
      Citations: 41     Fields:    Translation:HumansCells
    18. Balasenthil S, Huang Y, Liu S, Marsh T, Chen J, Stass SA, KuKuruga D, Brand R, Chen N, Frazier ML, Jack Lee J, Srivastava S, Sen S, McNeill Killary A. A Plasma Biomarker Panel to Identify Surgically Resectable Early-Stage Pancreatic Cancer. J Natl Cancer Inst. 2017 08 01; 109(8). PMID: 28376184; PMCID: PMC6059209.
      Citations: 31     Fields:    Translation:Humans
    19. Sasai K, Treekitkarnmongkol W, Kai K, Katayama H, Sen S. Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer. Front Oncol. 2016; 6:247. PMID: 27933271; PMCID: PMC5122578.
      Citations: 16     
    20. Treekitkarnmongkol W, Katayama H, Kai K, Sasai K, Jones JC, Wang J, Shen L, Sahin AA, Gagea M, Ueno NT, Creighton CJ, Sen S. Aurora kinase-A overexpression in mouse mammary epithelium induces mammary adenocarcinomas harboring genetic alterations shared with human breast cancer. Carcinogenesis. 2016 Dec; 37(12):1180-1189. PMID: 27624071; PMCID: PMC5137261.
      Citations: 15     Fields:    Translation:HumansAnimals
    21. Chen J, Wu X, Huang Y, Chen W, Brand RE, Killary AM, Sen S, Frazier ML. Identification of genetic variants predictive of early onset pancreatic cancer through a population science analysis of functional genomic datasets. Oncotarget. 2016 Aug 30; 7(35):56480-56490. PMID: 27486767; PMCID: PMC5302929.
      Citations: 5     Fields:    Translation:HumansCells
    22. Sasai K, Katayama H, Hawke DH, Sen S. Aurora-C Interactions with Survivin and INCENP Reveal Shared and Distinct Features Compared with Aurora-B Chromosome Passenger Protein Complex. PLoS One. 2016; 11(6):e0157305. PMID: 27332895; PMCID: PMC4917241.
      Citations: 9     Fields:    Translation:HumansCells
    23. Wang J, Chen J, Sen S. MicroRNA as Biomarkers and Diagnostics. J Cell Physiol. 2016 Jan; 231(1):25-30. PMID: 26031493; PMCID: PMC8776330.
      Citations: 223     Fields:    Translation:HumansAnimals
    24. Kai K, Kondo K, Wang X, Xie X, Pitner MK, Reyes ME, Torres-Adorno AM, Masuda H, Hortobagyi GN, Bartholomeusz C, Saya H, Tripathy D, Sen S, Ueno NT. Antitumor Activity of KW-2450 against Triple-Negative Breast Cancer by Inhibiting Aurora A and B Kinases. Mol Cancer Ther. 2015 Dec; 14(12):2687-99. PMID: 26443806; PMCID: PMC4674309.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Haab BB, Huang Y, Balasenthil S, Partyka K, Tang H, Anderson M, Allen P, Sasson A, Zeh H, Kaul K, Kletter D, Ge S, Bern M, Kwon R, Blasutig I, Srivastava S, Frazier ML, Sen S, Hollingsworth MA, Rinaudo JA, Killary AM, Brand RE. Definitive Characterization of CA 19-9 in Resectable Pancreatic Cancer Using a Reference Set of Serum and Plasma Specimens. PLoS One. 2015; 10(10):e0139049. PMID: 26431551; PMCID: PMC4592020.
      Citations: 17     Fields:    Translation:Humans
    26. Wang J, Yin H, Panandikar A, Gandhi V, Sen S. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. Int J Oncol. 2015 Aug; 47(2):782-90. PMID: 26058363; PMCID: PMC4501665.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    27. Fujii S, Srivastava V, Hegde A, Kondo Y, Shen L, Hoshino K, Gonzalez Y, Wang J, Sasai K, Ma X, Katayama H, Estecio MR, Hamilton SR, Wistuba I, Issa JP, Sen S. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumour Biol. 2015 Sep; 36(10):8147-58. PMID: 25990457.
      Citations: 4     Fields:    Translation:HumansCells
    28. Wang J, Paris PL, Chen J, Ngo V, Yao H, Frazier ML, Killary AM, Liu CG, Liang H, Mathy C, Bondada S, Kirkwood K, Sen S. Next generation sequencing of pancreatic cyst fluid microRNAs from low grade-benign and high grade-invasive lesions. Cancer Lett. 2015 Jan 28; 356(2 Pt B):404-9. PMID: 25304377; PMCID: PMC6200344.
      Citations: 59     Fields:    Translation:Humans
    29. Wang J, Raimondo M, Guha S, Chen J, Diao L, Dong X, Wallace MB, Killary AM, Frazier ML, Woodward TA, Wang J, Sen S. Circulating microRNAs in Pancreatic Juice as Candidate Biomarkers of Pancreatic Cancer. J Cancer. 2014; 5(8):696-705. PMID: 25258651; PMCID: PMC4174514.
      Citations: 63     
    30. Qi JH, Wang J, Chen J, Shen F, Huang JT, Sen S, Zhou X, Liu SM. High-resolution melting analysis reveals genetic polymorphisms in microRNAs confer hepatocellular carcinoma risk in Chinese patients. BMC Cancer. 2014 Aug 31; 14:643. PMID: 25176041; PMCID: PMC4161871.
      Citations: 15     Fields:    Translation:Humans
    31. Huang JT, Wang J, Srivastava V, Sen S, Liu SM. MicroRNA Machinery Genes as Novel Biomarkers for Cancer. Front Oncol. 2014; 4:113. PMID: 24904827; PMCID: PMC4032885.
      Citations: 33     
    32. Srivastava V, Sen S. Genetic variation in coding region of Aurora kinase A gene leads to cancer susceptibility. Cancer Epidemiol. 2014 Apr; 38(2):109-10. PMID: 24685408.
      Citations: 1     Fields:    Translation:Humans
    33. Wang J, Zhang KY, Liu SM, Sen S. Tumor-associated circulating microRNAs as biomarkers of cancer. Molecules. 2014 Feb 10; 19(2):1912-38. PMID: 24518808; PMCID: PMC6271223.
      Citations: 72     Fields:    Translation:HumansCells
    34. Chen N, Balasenthil S, Reuther J, Frayna A, Wang Y, Chandler DS, Abruzzo LV, Rashid A, Rodriguez J, Lozano G, Cao Y, Lokken E, Chen J, Frazier ML, Sahin AA, Wistuba II, Sen S, Lott ST, Killary AM. DEAR1 is a chromosome 1p35 tumor suppressor and master regulator of TGF-?-driven epithelial-mesenchymal transition. Cancer Discov. 2013 Oct; 3(10):1172-89. PMID: 23838884; PMCID: PMC4107927.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    35. Ling H, Spizzo R, Atlasi Y, Nicoloso M, Shimizu M, Redis RS, Nishida N, Song J, Guo Z, Ivan C, Barbarotto E, De Vries I, Zhang X, Ferracin M, Churchman M, van Galen JF, Beverloo BH, Shariati M, Haderk F, Estecio MR, Garcia-Manero G, Patijn GA, Gotley DC, Bhardwaj V, Shureiqi I, Sen S, Multani AS, Welsh J, Yamamoto K, Taniguchi I, Song MA, Gallinger S, Casey G, Thibodeau SN, Tiirikainen M, Mani SA, Zhang W, Davuluri RV, Mimori K, Mori M, Sieuwerts AM, Martens JW, Tomlinson I, Negrini M, Berindan-Neagoe I, Foekens JA, Hamilton SR, Lanza G, Kopetz S, Fodde R, Calin GA, Gaf? R, Le Marchand L. CCAT2, a novel noncoding RNA mapping to 8q24, underlies metastatic progression and chromosomal instability in colon cancer. Genome Res. 2013 Sep; 23(9):1446-61. PMID: 23796952; PMCID: PMC3759721.
      Citations: 314     Fields:    Translation:HumansAnimalsCells
    36. Liu Q, Chen J, Wang J, Amos C, Killary AM, Sen S, Wei C, Frazier ML. Putative tumor suppressor gene SEL1L was downregulated by aberrantly upregulated hsa-mir-155 in human pancreatic ductal adenocarcinoma. Mol Carcinog. 2014 Sep; 53(9):711-21. PMID: 23661430; PMCID: PMC3887131.
      Citations: 25     Fields:    Translation:HumansCells
    37. Yang G, Mercado-Uribe I, Multani AS, Sen S, Shih IeM, Wong KK, Gershenson DM, Liu J. RAS promotes tumorigenesis through genomic instability induced by imbalanced expression of Aurora-A and BRCA2 in midbody during cytokinesis. Int J Cancer. 2013 Jul 15; 133(2):275-85. PMID: 23319376; PMCID: PMC3883442.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    38. Qi J, Wang J, Katayama H, Sen S, Liu SM. Circulating microRNAs (cmiRNAs) as novel potential biomarkers for hepatocellular carcinoma. Neoplasma. 2013; 60(2):135-42. PMID: 23259781; PMCID: PMC3869230.
      Citations: 67     Fields:    Translation:Humans
    39. Torchia EC, Zhang L, Huebner AJ, Sen S, Roop DR. Aurora kinase-A deficiency during skin development impairs cell division and stratification. J Invest Dermatol. 2013 Jan; 133(1):78-86. PMID: 22832491; PMCID: PMC3494779.
      Citations: 8     Fields:    Translation:AnimalsCells
    40. Katayama H, Wang J, Treekitkarnmongkol W, Kawai H, Sasai K, Zhang H, Wang H, Adams HP, Jiang S, Chakraborty SN, Suzuki F, Arlinghaus RB, Liu J, Mobley JA, Grizzle WE, Wang H, Sen S. Aurora kinase-A inactivates DNA damage-induced apoptosis and spindle assembly checkpoint response functions of p73. Cancer Cell. 2012 Feb 14; 21(2):196-211. PMID: 22340593; PMCID: PMC3760020.
      Citations: 49     Fields:    Translation:HumansCells
    41. Derenzini E, Lemoine M, Buglio D, Katayama H, Ji Y, Davis RE, Sen S, Younes A. The JAK inhibitor AZD1480 regulates proliferation and immunity in Hodgkin lymphoma. Blood Cancer J. 2011 Dec; 1(12):e46. PMID: 22829094; PMCID: PMC3255510.
      Citations: 34     Fields:    
    42. Wang J, Sen S. MicroRNA functional network in pancreatic cancer: from biology to biomarkers of disease. J Biosci. 2011 Aug; 36(3):481-91. PMID: 21799259.
      Citations: 39     Fields:    Translation:Humans
    43. Chen J, Wu X, Pande M, Amos CI, Killary AM, Sen S, Frazier ML. Susceptibility locus for lung cancer at 15q25.1 is not associated with risk of pancreatic cancer. Pancreas. 2011 Aug; 40(6):872-5. PMID: 21697764; PMCID: PMC3138891.
      Citations: 5     Fields:    Translation:HumansCells
    44. Anantharaman D, Samant TA, Sen S, Mahimkar MB. Polymorphisms in tobacco metabolism and DNA repair genes modulate oral precancer and cancer risk. Oral Oncol. 2011 Sep; 47(9):866-72. PMID: 21741876.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    45. Liu Q, Chen J, Mai B, Amos C, Killary AM, Sen S, Wei C, Frazier ML. A single-nucleotide polymorphism in tumor suppressor gene SEL1L as a predictive and prognostic marker for pancreatic ductal adenocarcinoma in Caucasians. Mol Carcinog. 2012 May; 51(5):433-8. PMID: 21656579; PMCID: PMC3780592.
      Citations: 8     Fields:    Translation:Humans
    46. Katayama H, Sen S. Functional significance of Aurora kinase A regulatory interactions with p53-ERa complex in human breast cancer cells. Horm Cancer. 2011 Apr; 2(2):117-24. PMID: 21761334; PMCID: PMC10357986.
      Citations: 5     Fields:    Translation:HumansCells
    47. Balasenthil S, Chen N, Lott ST, Chen J, Carter J, Grizzle WE, Frazier ML, Sen S, Killary AM. A migration signature and plasma biomarker panel for pancreatic adenocarcinoma. Cancer Prev Res (Phila). 2011 Jan; 4(1):137-49. PMID: 21071578; PMCID: PMC3635082.
      Citations: 22     Fields:    Translation:HumansCells
    48. Katayama H, Sen S. Aurora kinase inhibitors as anticancer molecules. Biochim Biophys Acta. 2010 Oct-Dec; 1799(10-12):829-39. PMID: 20863917; PMCID: PMC4501772.
      Citations: 63     Fields:    Translation:HumansAnimals
    49. Kamal A, Dastagiri D, Ramaiah MJ, Bharathi EV, Reddy JS, Balakishan G, Sarma P, Pushpavalli SN, Pal-Bhadra M, Juvekar A, Sen S, Zingde S. Synthesis, anticancer activity and mitochondrial mediated apoptosis inducing ability of 2,5-diaryloxadiazole-pyrrolobenzodiazepine conjugates. Bioorg Med Chem. 2010 Sep 15; 18(18):6666-77. PMID: 20732817.
      Citations:    Fields:    Translation:HumansAnimalsCells
    50. Molli PR, Li DQ, Bagheri-Yarmand R, Pakala SB, Katayama H, Sen S, Iyer J, Chernoff J, Tsai MY, Nair SS, Kumar R. Arpc1b, a centrosomal protein, is both an activator and substrate of Aurora A. J Cell Biol. 2010 Jul 12; 190(1):101-14. PMID: 20603326; PMCID: PMC2911675.
      Citations: 32     Fields:    Translation:HumansCells
    51. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15; 16(12):3171-81. PMID: 20423983; PMCID: PMC2930838.
      Citations: 63     Fields:    Translation:HumansCells
    52. Jiang S, Katayama H, Wang J, Li SA, Hong Y, Radvanyi L, Li JJ, Sen S. Estrogen-induced aurora kinase-A (AURKA) gene expression is activated by GATA-3 in estrogen receptor-positive breast cancer cells. Horm Cancer. 2010 Feb; 1(1):11-20. PMID: 21761347; PMCID: PMC4501777.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    53. Frenkel M, Mishra BM, Sen S, Yang P, Pawlus A, Vence L, Leblanc A, Cohen L, Banerji P, Banerji P. Cytotoxic effects of ultra-diluted remedies on breast cancer cells. Int J Oncol. 2010 Feb; 36(2):395-403. PMID: 20043074.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    54. Chen J, Amos CI, Merriman KW, Wei Q, Sen S, Killary AM, Frazier ML. Genetic variants of p21 and p27 and pancreatic cancer risk in non-Hispanic Whites: a case-control study. Pancreas. 2010 Jan; 39(1):1-4. PMID: 19910837; PMCID: PMC2796289.
      Citations: 6     Fields:    Translation:Humans
    55. Zhu J, Sen S, Wei C, Frazier ML. Cyclin D1b represses breast cancer cell growth by antagonizing the action of cyclin D1a on estrogen receptor alpha-mediated transcription. Int J Oncol. 2010 Jan; 36(1):39-48. PMID: 19956831.
      Citations: 8     Fields:    Translation:HumansCells
    56. Sen S, Hopwood V. Molecular cytogenetic evidence for multistep tumorigenesis: implications for risk assessment and early detection. Cancer Biomark. 2010; 9(1-6):113-32. PMID: 22112472.
      Citations: 2     Fields:    Translation:HumansAnimals
    57. Sen S. Aurora-C: the youngest of "the three (Aurora kinase) tenors" of mitotic symphony. Cell Cycle. 2009 Oct 01; 8(19):3076-7. PMID: 19823009.
      Citations: 1     Fields:    Translation:HumansCells
    58. Torchia EC, Chen Y, Sheng H, Katayama H, Fitzpatrick J, Brinkley WR, Caulin C, Sen S, Roop DR. A genetic variant of Aurora kinase A promotes genomic instability leading to highly malignant skin tumors. Cancer Res. 2009 Sep 15; 69(18):7207-15. PMID: 19738056; PMCID: PMC2745523.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    59. Wang J, Chen J, Chang P, LeBlanc A, Li D, Abbruzzesse JL, Frazier ML, Killary AM, Sen S. MicroRNAs in plasma of pancreatic ductal adenocarcinoma patients as novel blood-based biomarkers of disease. Cancer Prev Res (Phila). 2009 Sep; 2(9):807-13. PMID: 19723895; PMCID: PMC5859193.
      Citations: 259     Fields:    Translation:Humans
    60. Lott ST, Chen N, Chandler DS, Yang Q, Wang L, Rodriguez M, Xie H, Balasenthil S, Buchholz TA, Sahin AA, Chaung K, Zhang B, Olufemi SE, Chen J, Adams H, Band V, El-Naggar AK, Frazier ML, Keyomarsi K, Hunt KK, Sen S, Haffty B, Hewitt SM, Krahe R, Killary AM. DEAR1 is a dominant regulator of acinar morphogenesis and an independent predictor of local recurrence-free survival in early-onset breast cancer. PLoS Med. 2009 May 26; 6(5):e1000068. PMID: 19536326; PMCID: PMC2673042.
      Citations: 23     Fields:    Translation:HumansCells
    61. Mazumdar A, Henderson YC, El-Naggar AK, Sen S, Clayman GL. Aurora kinase A inhibition and paclitaxel as targeted combination therapy for head and neck squamous cell carcinoma. Head Neck. 2009 May; 31(5):625-34. PMID: 19107951; PMCID: PMC2668723.
      Citations: 33     Fields:    Translation:HumansCells
    62. Chen J, Li D, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p16, p27, p73, and MDM2 modulate response and survival of pancreatic cancer patients treated with preoperative chemoradiation. Ann Surg Oncol. 2009 Feb; 16(2):431-9. PMID: 19020940.
      Citations: 20     Fields:    Translation:HumansCTClinical Trials
    63. Inamdar KV, O'Brien S, Sen S, Keating M, Nguyen MH, Wang X, Fernandez M, Thomazy V, Medeiros LJ, Bueso-Ramos CE. Aurora-A kinase nuclear expression in chronic lymphocytic leukemia. Mod Pathol. 2008 Dec; 21(12):1428-35. PMID: 18931650.
      Citations: 3     Fields:    Translation:HumansCells
    64. Park HS, Park WS, Bondaruk J, Tanaka N, Katayama H, Lee S, Spiess PE, Steinberg JR, Wang Z, Katz RL, Dinney C, Elias KJ, Lotan Y, Naeem RC, Baggerly K, Sen S, Grossman HB, Czerniak B. Quantitation of Aurora kinase A gene copy number in urine sediments and bladder cancer detection. J Natl Cancer Inst. 2008 Oct 01; 100(19):1401-11. PMID: 18812553; PMCID: PMC2720731.
      Citations: 34     Fields:    Translation:HumansCells
    65. Katayama H, Sasai K, Kloc M, Brinkley BR, Sen S. Aurora kinase-A regulates kinetochore/chromatin associated microtubule assembly in human cells. Cell Cycle. 2008 Sep 01; 7(17):2691-704. PMID: 18773538.
      Citations: 29     Fields:    Translation:HumansCells
    66. Chen J, Killary AM, Sen S, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Polymorphisms of p21 and p27 jointly contribute to an earlier age at diagnosis of pancreatic cancer. Cancer Lett. 2008 Dec 08; 272(1):32-9. PMID: 18694622; PMCID: PMC3780599.
      Citations: 6     Fields:    Translation:Humans
    67. Sen S, Katayama H, Sasai K. Functional significance of Aurora kinase A in centrosome amplification and genomic instability. Adv Exp Med Biol. 2008; 617:99-108. PMID: 18497034.
      Citations: 10     Fields:    Translation:HumansCells
    68. Katayama H, Sasai K, Czerniak BA, Carter JL, Sen S. Aurora-A kinase phosphorylation of Aurora-A kinase interacting protein (AIP) and stabilization of the enzyme-substrate complex. J Cell Biochem. 2007 Dec 01; 102(5):1318-31. PMID: 17957726.
      Citations: 4     Fields:    Translation:HumansCells
    69. Chen J, Li D, Wei C, Sen S, Killary AM, Amos CI, Evans DB, Abbruzzese JL, Frazier ML. Aurora-A and p16 polymorphisms contribute to an earlier age at diagnosis of pancreatic cancer in Caucasians. Clin Cancer Res. 2007 May 15; 13(10):3100-4. PMID: 17505013; PMCID: PMC2365501.
      Citations: 27     Fields:    Translation:Humans
    70. Chen J, Sen S, Amos CI, Wei C, Jones JS, Lynch P, Frazier ML. Association between Aurora-A kinase polymorphisms and age of onset of hereditary nonpolyposis colorectal cancer in a Caucasian population. Mol Carcinog. 2007 Apr; 46(4):249-56. PMID: 17219423.
      Citations: 14     Fields:    Translation:Humans
    71. Shi Y, Reiman T, Li W, Maxwell CA, Sen S, Pilarski L, Daniels TR, Penichet ML, Feldman R, Lichtenstein A. Targeting aurora kinases as therapy in multiple myeloma. Blood. 2007 May 01; 109(9):3915-21. PMID: 17213289; PMCID: PMC1874561.
      Citations: 33     Fields:    Translation:HumansCellsCTClinical Trials
    72. Hu Q, Lu JF, Luo R, Sen S, Maity SN. Inhibition of CBF/NF-Y mediated transcription activation arrests cells at G2/M phase and suppresses expression of genes activated at G2/M phase of the cell cycle. Nucleic Acids Res. 2006; 34(21):6272-85. PMID: 17098936; PMCID: PMC1693888.
      Citations: 23     Fields:    Translation:HumansCells
    73. Hu W, Kavanagh JJ, Deaver M, Johnston DA, Freedman RS, Verschraegen CF, Sen S. Frequent overexpression of STK15/Aurora-A/BTAK and chromosomal instability in tumorigenic cell cultures derived from human ovarian cancer. Oncol Res. 2005; 15(1):49-57. PMID: 15839305.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    74. Sasai K, Katayama H, Stenoien DL, Fujii S, Honda R, Kimura M, Okano Y, Tatsuka M, Suzuki F, Nigg EA, Earnshaw WC, Brinkley WR, Sen S. Aurora-C kinase is a novel chromosomal passenger protein that can complement Aurora-B kinase function in mitotic cells. Cell Motil Cytoskeleton. 2004 Dec; 59(4):249-63. PMID: 15499654.
      Citations: 85     Fields:    Translation:HumansCells
    75. Fraizer GC, Diaz MF, Lee IL, Grossman HB, Sen S. Aurora-A/STK15/BTAK enhances chromosomal instability in bladder cancer cells. Int J Oncol. 2004 Dec; 25(6):1631-9. PMID: 15547700.
      Citations: 19     Fields:    Translation:HumansCells
    76. Ouchi M, Fujiuchi N, Sasai K, Katayama H, Minamishima YA, Ongusaha PP, Deng C, Sen S, Lee SW, Ouchi T. BRCA1 phosphorylation by Aurora-A in the regulation of G2 to M transition. J Biol Chem. 2004 May 07; 279(19):19643-8. PMID: 14990569.
      Citations: 75     Fields:    Translation:HumansAnimalsCells
    77. Royce ME, Xia W, Sahin AA, Katayama H, Johnston DA, Hortobagyi G, Sen S, Hung MC. STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis. Cancer. 2004 Jan 01; 100(1):12-9. PMID: 14692019.
      Citations: 20     Fields:    Translation:HumansCells
    78. Katayama H, Sasai K, Kawai H, Yuan ZM, Bondaruk J, Suzuki F, Fujii S, Arlinghaus RB, Czerniak BA, Sen S. Phosphorylation by aurora kinase A induces Mdm2-mediated destabilization and inhibition of p53. Nat Genet. 2004 Jan; 36(1):55-62. PMID: 14702041.
      Citations: 240     Fields:    Translation:HumansCells
    79. Hoque A, Carter J, Xia W, Hung MC, Sahin AA, Sen S, Lippman SM. Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. Cancer Epidemiol Biomarkers Prev. 2003 Dec; 12(12):1518-22. PMID: 14693746.
      Citations: 28     Fields:    Translation:Humans
    80. Katayama H, Brinkley WR, Sen S. The Aurora kinases: role in cell transformation and tumorigenesis. Cancer Metastasis Rev. 2003 Dec; 22(4):451-64. PMID: 12884918.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    81. Mayer F, Stoop H, Sen S, Bokemeyer C, Oosterhuis JW, Looijenga LH. Aneuploidy of human testicular germ cell tumors is associated with amplification of centrosomes. Oncogene. 2003 Jun 19; 22(25):3859-66. PMID: 12813459.
      Citations: 20     Fields:    Translation:HumansCells
    82. Li D, Zhu J, Firozi PF, Abbruzzese JL, Evans DB, Cleary K, Friess H, Sen S. Overexpression of oncogenic STK15/BTAK/Aurora A kinase in human pancreatic cancer. Clin Cancer Res. 2003 Mar; 9(3):991-7. PMID: 12631597.
      Citations: 125     Fields:    Translation:HumansCells
    83. Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Mandal M, Kumar R. p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep. 2002 Aug; 3(8):767-73. PMID: 12151336; PMCID: PMC1084211.
      Citations: 50     Fields:    Translation:HumansCells
    84. Fimia GM, Loury R, Kimura M, Okano Y, Zhou H, Sen S, Allis CD, Sassone-Corsi P, Crosio C. Mitotic phosphorylation of histone H3: spatio-temporal regulation by mammalian Aurora kinases. Mol Cell Biol. 2002 Feb; 22(3):874-85. PMID: 11784863; PMCID: PMC133550.
      Citations: 258     Fields:    Translation:HumansAnimalsCells
    85. Katayama H, Zhou H, Li Q, Tatsuka M, Sen S. Interaction and feedback regulation between STK15/BTAK/Aurora-A kinase and protein phosphatase 1 through mitotic cell division cycle. J Biol Chem. 2001 Dec 07; 276(49):46219-24. PMID: 11551964.
      Citations: 65     Fields:    Translation:HumansCells
    86. Sen S. Aneuploidy and cancer. Curr Opin Oncol. 2000 Jan; 12(1):82-8. PMID: 10687734.
      Citations: 64     Fields:    Translation:Humans
    87. Multani AS, Ozen M, Sen S, Mandal AK, Price JE, Fan D, Radinsky R, Ali-Osman F, Von Eschenbach AC, Fidler IJ, Pathak S. Amplification of telomeric DNA directly correlates with metastatic potential of human and murine cancers of various histological origin. Int J Oncol. 1999 Sep; 15(3):423-9. PMID: 10427120.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    88. Multani AS, Chandra J, Mcconker J, Sen S, Cabral TF, Pathak S. Cell death in paclitaxel-dependent chinese hamster ovary cells is initiated by the loss of telomeric DNA repeats. Oncol Res. 1999; 11(10):455-60. PMID: 10850886.
      Citations: 1     Fields:    Translation:AnimalsCells
    89. Zhou H, Kuang J, Zhong L, Kuo WL, Gray JW, Sahin A, Brinkley BR, Sen S. Tumour amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet. 1998 Oct; 20(2):189-93. PMID: 9771714.
      Citations: 412     Fields:    Translation:HumansAnimalsCells
    90. Venugopalan M, Wood TF, Wilczynski SP, Sen S, Peters J, Ma GC, Evans GA, Srivatsan ES. Loss of heterozygosity in squamous cell carcinomas of the head and neck defines a tumor suppressor gene region on 11q13. Cancer Genet Cytogenet. 1998 Jul 15; 104(2):124-32. PMID: 9666806.
      Citations: 4     Fields:    Translation:HumansCells
    91. Kuo MT, Sen S, Hittelman WN, Hsu TC. Chromosomal fragile sites and DNA amplification in drug-resistant cells. Biochem Pharmacol. 1998 Jul 01; 56(1):7-13. PMID: 9698083.
      Citations: 5     Fields:    Translation:HumansAnimals
    92. Sen S, Zhou H, Ripmaster T, Hittelman WN, Schimmel P, White RA. Expression of a gene encoding a tRNA synthetase-like protein is enhanced in tumorigenic human myeloid leukemia cells and is cell cycle stage- and differentiation-dependent. Proc Natl Acad Sci U S A. 1997 Jun 10; 94(12):6164-9. PMID: 9177188; PMCID: PMC21020.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    93. Sen S, Zhou H, White RA. A putative serine/threonine kinase encoding gene BTAK on chromosome 20q13 is amplified and overexpressed in human breast cancer cell lines. Oncogene. 1997 May 08; 14(18):2195-200. PMID: 9174055.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    94. Sen S, Zhou H, Andersson BS, Cork A, Freireich EJ, Stass SA. p53 gene mutations with chromosome 17 abnormalities in chronic myelogenous leukemia blast crisis patients persist in long-term cell lines but may be acquired in acute myeloid leukemia cells in vitro. Cancer Genet Cytogenet. 1995 Jul 01; 82(1):35-40. PMID: 7627932.
      Citations: 1     Fields:    Translation:HumansCells
    95. Jesudasan RA, Slovak ML, Sen S, Srivatsan ES. Rearrangement of chromosome band 11q13 in HeLa cells. Anticancer Res. 1994 Sep-Oct; 14(5A):1727-33. PMID: 7847806.
      Citations: 2     Fields:    Translation:HumansCells
    96. Sen S, Sen P, Mulac-Jericevic B, Zhou H, Pirrotta V, Stass SA. Microdissected double-minute DNA detects variable patterns of chromosomal localizations and multiple abundantly expressed transcripts in normal and leukemic cells. Genomics. 1994 Feb; 19(3):542-51. PMID: 8188297.
      Citations: 1     Fields:    Translation:HumansCells
    97. Sen S, Takahashi R, Rani S, Freireich EJ, Stass SA. Expression of differentially phosphorylated Rb and mutant p53 proteins in myeloid leukemia cell lines. Leuk Res. 1993 Aug; 17(8):639-47. PMID: 8355507.
      Citations: 6     Fields:    Translation:HumansCells
    98. Andersson BS, Bergerheim US, Collins VP, Childs C, Beran M, Sen S, Arden K, Pathak S, Siciliano MJ, Ost A, et al. KBM-3, an in vitro model of human acute myelomonocytic leukemia. Exp Hematol. 1992 Mar; 20(3):361-7. PMID: 1568450.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    99. Sen S, Rani S, Freireich EJ, Hewitt R, Stass SA. Detection of extrachromosomal circular DNA sequences from tumor cells by an alkaline lysis, Alu-polymerase chain reaction technique. Mol Carcinog. 1992; 5(2):107-10. PMID: 1554408.
      Citations: 3     Fields:    Translation:HumansCells
    100. Sen S, Hittelman WN, Teeter LD, Kuo MT. Model for the formation of double minutes from prematurely condensed chromosomes of replicating micronuclei in drug-treated Chinese hamster ovary cells undergoing DNA amplification. Cancer Res. 1989 Dec 01; 49(23):6731-7. PMID: 2819718.
      Citations: 11     Fields:    Translation:AnimalsCells
    101. Sun YL, Pao CI, Sen S, Kuo T. High-resolution mapping of DNase I hypersensitive site in the chicken beta-tubulin gene transfected into monkey cells. J Biol Chem. 1987 Jun 05; 262(16):7764-9. PMID: 3584140.
      Citations: 1     Fields:    Translation:AnimalsCells
    102. Sen S, Teeter LD, Kuo T. Specific gene amplification associated with consistent chromosomal abnormality in independently established multidrug-resistant Chinese hamster ovary cells. Chromosoma. 1987; 95(2):117-25. PMID: 3595311.
      Citations: 1     Fields:    Translation:AnimalsCells
    103. Teeter LD, Sanford JA, Sen S, Stallings RL, Siciliano MJ, Kuo MT. Multidrug-resistant phenotype cosegregates with an amplified gene in somatic cell hybrids of drug-resistant Chinese hamster ovary cells and drug-sensitive murine cells. Mol Cell Biol. 1986 Dec; 6(12):4268-73. PMID: 3796603; PMCID: PMC367208.
      Citations: 1     Fields:    Translation:AnimalsCells
    104. Teeter LD, Atsumi S, Sen S, Kuo T. DNA amplification in multidrug, cross-resistant Chinese hamster ovary cells: molecular characterization and cytogenetic localization of the amplified DNA. J Cell Biol. 1986 Oct; 103(4):1159-66. PMID: 3771630; PMCID: PMC2114345.
      Citations: 5     Fields:    Translation:AnimalsCells
    105. Sharma T, Cheong N, Sen P, Sen S. Constitutive heterochromatin and evolutionary divergence of Mus dunni, M. booduga and M. musculus. Curr Top Microbiol Immunol. 1986; 127:35-44. PMID: 3731852.
      Citations: 6     Fields:    Translation:AnimalsCells
    106. Sen S, Siciliano MJ, Johnston DA, Schwartz RJ, Kuo T. The expression and chromatin structure of the chicken glyceraldehyde-3-phosphate dehydrogenase gene in mouse cells. J Biol Chem. 1985 Mar 10; 260(5):3071-8. PMID: 3972817.
      Citations: 2     Fields:    Translation:AnimalsCells
    107. Kuo MT, Sen S, Teeter L, Cailleau RM, Knesek JE, Bowen J. Expression of endogenous murine leukemia virus in transplantable tumor cells and DNA methylation of the viral sequences. Cancer Res. 1984 Aug; 44(8):3518-21. PMID: 6331650.
      Citations:    Fields:    Translation:AnimalsCells
    108. Sen S, Sharma T. Asynchronous replication of constitutive heterochromatin on X chromosomes in female Mus dunni. Possible influence of facultative heterochromatin on the adjacent constitutive heterochromatin. Chromosoma. 1982; 85(1):119-26. PMID: 7094696.
      Citations: 1     Fields:    Translation:AnimalsCells
    109. Sen S, Sharma T. Quantitative variation of "Mus musculus-like" constitutive heterochromatin and satellite DNA-sequences in the genus Mus. Chromosoma. 1980; 81(3):393-402. PMID: 7449568.
      Citations: 3     Fields:    Translation:AnimalsCells
    110. Genomic and expression array profiling of chromosome 20q amplicon in human colon cancer cells. Indian Journal of Human Genetics. 11:128-134.
    111. Sparse distribution of constitutive heterochromatin and its variation in two species of mongooses (Carnivora) with exact G-band homology. Genetica. 50:221-226.
    112. Elevated cyclin A associated kinase activity promotes sensitivity of metastatic human cancer cells to DNA antimetabolite drug. International Journal of Oncology. 47:782-790.
    113. Aurora-A Kinase. Medicinal Research Reviews.
    114. Antitumor activity of KW-2450 against triple-negative breast cancer by inhibiting Aurora A and B kinases. Molecular Cancer Therapeutics. 14:2687-2699.
    115. Functional significance of Aurora kinases-p53 protein family interactions in cancer. Frontiers in Oncology. 6.
    116. Micrornas in solid tumors. 45-65.
    117. MicroRNA machinery genes as novel biomarkers for cancer. Frontiers in Oncology. 4 MAY.
    118. Structural analysis of the expression of the chicken glyceraldehyde-3-phosphate dehydrogenase gene. Federation Proceedings. 44.
    119. Regulation of AURKC expression by CpG island methylation in human cancer cells. Tumor Biology.
    120. Aurora-C interactions with survivin and incenp reveal shared and distinct features compared with aurora-B chromosome passenger protein complex. PLoS One. 11.
    121. STK15/BTAK/aurora-A expression in ductal carcinoma in situ of the breast. Breast Cancer Research and Treatment. 69:250.
    122. Aurora kinases. 371-389.
    123. Molecular cytogenetic evidence for multistep tumorigenesis. 113-132.
    124. Circulating microRNAs in pancreatic juice as candidate biomarkers of pancreatic cancer. Journal of Cancer. 5:696-705.
    125. P53 alterations show significant correlation with gene amplification and high S-phase index in breast cancer. International Journal of Oncology. 6:955-962.
    126. Definitive characterization of CA 19-9 in resectable pancreatic cancer using a reference set of serum and plasma specimens. PLoS One. 10.
    127. High level of STK-15 expression in primary breast tumors correlates with nuclear grade. Breast Cancer Research and Treatment. 69:266.
    128. Identification of genetic variants predictive of early onset pancreatic cancer through a population science analysis of functional genomic datasets. Oncotarget. 7:56480-56490.
    129. Erratum. Journal of Biological Chemistry. 290:22311.
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