DIHUA YU

TitleProfessor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ye Z, Xu S, Shi Y, Cheng X, Zhang Y, Roy S, Namjoshi S, Longo MA, Link TM, Schlacher K, Peng G, Yu D, Wang B, Tainer JA, Ahmed Z. GRB2 stabilizes RAD51 at reversed replication forks suppressing genomic instability and innate immunity against cancer. Nat Commun. 2024 Mar 08; 15(1):2132. PMID: 38459011; PMCID: PMC10923831.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Akkoc Mustafayev FN, Liu DD, Gutierrez AM, Lewis JE, Ibrahim NK, Valero V, Booser DJ, Litton JK, Koenig K, Yu D, Sneige N, Arun BK. Short-Term Biomarker Modulation Study of Dasatinib for Estrogen Receptor-Negative Breast Cancer Chemoprevention. Eur J Breast Health. 2023 Oct; 19(4):267-273. PMID: 37795002; PMCID: PMC10546803.
      Citations:    
    3. Yuzhalin AE, Yu D. Critical functions of extracellular matrix in brain metastasis seeding. Cell Mol Life Sci. 2023 Sep 20; 80(10):297. PMID: 37728789; PMCID: PMC10511571.
      Citations:    Fields:    Translation:HumansCells
    4. Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung MC, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 08 08; 35(8):1457-1473.e13. PMID: 37329887; PMCID: PMC10712687.
      Citations: 2     Fields:    Translation:AnimalsCells
    5. Wang YN, Lee HH, Jiang Z, Chan LC, Hortobagyi GN, Yu D, Hung MC. Ribonuclease 1 Enhances Antitumor Immunity against Breast Cancer by Boosting T cell Activation. Int J Biol Sci. 2023; 19(10):2957-2973. PMID: 37416781; PMCID: PMC10321278.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    6. Sun C, Ye Y, Tan Z, Liu Y, Li Y, Hu W, Liang K, Egranov SD, Huang LA, Zhang Z, Zhang Y, Yao J, Nguyen TK, Zhao Z, Wu A, Marks JR, Caudle AS, Sahin AA, Gao J, Gammon ST, Piwnica-Worms D, Hu J, Chiao PJ, Yu D, Hung MC, Curran MA, Calin GA, Ying H, Han L, Lin C, Yang L. Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Sci Adv. 2023 02 03; 9(5):eadd6995. PMID: 36724291; PMCID: PMC9891701.
      Citations: 5     Fields:    Translation:HumansCells
    7. Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Lim B, Lehmann LH, Salem JE, Johnson DB, Curran MA, Yu D, Han L, Darabi R, Yang L, Moslehi JJ, Lin C. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Sci Transl Med. 2022 11 02; 14(669):eabo1981. PMID: 36322628; PMCID: PMC9809130.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    8. Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC, Yamaguchi H, Jiang Z, Liu C, Li CF, Nie L, Chan LC, Gao Y, Wang SC, Liu J, Westin SN, Lee S, Sood AK, Yang L, Hortobagyi GN, Yu D, Hung MC. Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022 10; 3(10):1211-1227. PMID: 36253486; PMCID: PMC9586872.
      Citations: 1     Fields:    Translation:HumansAnimals
    9. Yuan X, Duan Y, Xiao Y, Sun K, Qi Y, Zhang Y, Ahmed Z, Moiani D, Yao J, Li H, Zhang L, Yuzhalin AE, Li P, Zhang C, Badu-Nkansah A, Saito Y, Liu X, Kuo WL, Ying H, Sun SC, Chang JC, Tainer JA, Yu D. Vitamin E Enhances Cancer Immunotherapy by Reinvigorating Dendritic Cells via Targeting Checkpoint SHP1. Cancer Discov. 2022 07 06; 12(7):1742-1759. PMID: 35420681; PMCID: PMC9262841.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Zhao X, Wei Y, Chu YY, Li Y, Hsu JM, Jiang Z, Liu C, Hsu JL, Chang WC, Yang R, Chan LC, Qu J, Zhang S, Ying H, Yu D, Hung MC. Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function. Cancer Res. 2022 06 06; 82(11):2185-2195. PMID: 35385574.
      Citations:    Fields:    Translation:HumansAnimalsCells
    11. Zhang L, Qu J, Qi Y, Duan Y, Huang YW, Zhou Z, Li P, Yao J, Huang B, Zhang S, Yu D. EZH2 engages TGF? signaling to promote breast cancer bone metastasis via integrin ?1-FAK activation. Nat Commun. 2022 05 10; 13(1):2543. PMID: 35538070; PMCID: PMC9091212.
      Citations:    Fields:    Translation:HumansCells
    12. Cha JH, Chan LC, Wang YN, Chu YY, Wang CH, Lee HH, Xia W, Shyu WC, Liu SP, Yao J, Chang CW, Cheng FR, Liu J, Lim SO, Hsu JL, Yang WH, Hortobagyi GN, Lin C, Yang L, Yu D, Jeng LB, Hung MC. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. J Biol Chem. 2022 04; 298(4):101817. PMID: 35278434; PMCID: PMC8988001.
      Citations:    Fields:    Translation:HumansAnimalsCells
    13. Wang YN, Lee HH, Wei Y, Chu YY, Xia W, Wang M, Yu D, Hung MC. An optimized protocol for PD-L1 pathological assessment with patient sample deglycosylation to improve correlation with therapeutic response. STAR Protoc. 2022 03 18; 3(1):101198. PMID: 35243381; PMCID: PMC8885744.
      Citations:    Fields:    Translation:Humans
    14. Li H, Xiao Y, Li Q, Yao J, Yuan X, Zhang Y, Yin X, Saito Y, Fan H, Li P, Kuo WL, Halpin A, Gibbons DL, Yagita H, Zhao Z, Pang D, Ren G, Yee C, Lee JJ, Yu D. The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1. Cancer Cell. 2022 01 10; 40(1):36-52.e9. PMID: 34822775; PMCID: PMC8779329.
      Citations: 13     Fields:    Translation:HumansCells
    15. Shaim H, Shanley M, Basar R, Daher M, Gumin J, Zamler DB, Uprety N, Wang F, Huang Y, Gabrusiewicz K, Miao Q, Dou J, Alsuliman A, Kerbauy LN, Acharya S, Mohanty V, Mendt M, Li S, Lu J, Wei J, Fowlkes NW, Gokdemir E, Ensley EL, Kaplan M, Kassab C, Li L, Ozcan G, Banerjee PP, Shen Y, Gilbert AL, Jones CM, Bdiwi M, Nunez-Cortes AK, Liu E, Yu J, Imahashi N, Muniz-Feliciano L, Li Y, Hu J, Draetta G, Marin D, Yu D, Champlin RE, Chen K, Lang FF, Shpall EJ, Heimberger AB, Rezvani K, Mielke S, Eyrich M. Targeting the av integrin/TGF-? axis improves natural killer cell function against glioblastoma stem cells. J Clin Invest. 2021 07 15; 131(14). PMID: 34138753; PMCID: PMC8279586.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    16. Wang J, Zhang Y, Xiao Y, Yuan X, Li P, Wang X, Duan Y, Seewaldt VL, Yu D. Boosting immune surveillance by low-dose PI3K inhibitor facilitates early intervention of breast cancer. Am J Cancer Res. 2021; 11(5):2005-2024. PMID: 34094666; PMCID: PMC8167687.
      Citations: 1     
    17. Lee HH, Wang YN, Yang WH, Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi H, Pang D, Hortobagyi GN, Yu D, Hung MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021 05 13; 12(1):2788. PMID: 33986289; PMCID: PMC8119676.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    18. Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest. 2021 04 15; 131(8). PMID: 33855973; PMCID: PMC8262501.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    19. Yang R, Sun L, Li CF, Wang YH, Yao J, Li H, Yan M, Chang WC, Hsu JM, Cha JH, Hsu JL, Chou CW, Sun X, Deng Y, Chou CK, Yu D, Hung MC. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Nat Commun. 2021 02 05; 12(1):832. PMID: 33547304; PMCID: PMC7864927.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    20. Fukumura K, Malgulwar PB, Fischer GM, Hu X, Mao X, Song X, Hernandez SD, Zhang XH, Zhang J, Parra ER, Yu D, Debeb BG, Davies MA, Huse JT. Multi-omic molecular profiling reveals potentially targetable abnormalities shared across multiple histologies of brain metastasis. Acta Neuropathol. 2021 02; 141(2):303-321. PMID: 33394124; PMCID: PMC7852029.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    21. Xiao Y, Yu D. Tumor microenvironment as a therapeutic target in cancer. Pharmacol Ther. 2021 05; 221:107753. PMID: 33259885; PMCID: PMC8084948.
      Citations: 28     Fields:    Translation:Humans
    22. Wang YN, Lee HH, Hsu JL, Yu D, Hung MC. The impact of PD-L1?N-linked glycosylation on cancer therapy and clinical diagnosis. J Biomed Sci. 2020 Jul 03; 27(1):77. PMID: 32620165; PMCID: PMC7333976.
      Citations: 30     Fields:    Translation:HumansCells
    23. Zhang L, Yao J, Wei Y, Zhou Z, Li P, Qu J, Badu-Nkansah A, Yuan X, Huang YW, Fukumura K, Mao X, Chang WC, Saunus J, Lakhani S, Huse JT, Hung MC, Yu D. Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases. Sci Transl Med. 2020 05 27; 12(545). PMID: 32461334; PMCID: PMC7948522.
      Citations: 21     Fields:    Translation:AnimalsCells
    24. Yuzhalin AE, Yu D. Brain Metastasis Organotropism. Cold Spring Harb Perspect Med. 2020 05 01; 10(5). PMID: 31548224; PMCID: PMC7197417.
      Citations: 6     Fields:    Translation:Humans
    25. Acharya S, Yao J, Li P, Zhang C, Lowery FJ, Zhang Q, Guo H, Qu J, Yang F, Wistuba II, Piwnica-Worms H, Sahin AA, Yu D. Sphingosine Kinase 1 Signaling Promotes Metastasis of Triple-Negative Breast Cancer. Cancer Res. 2019 08 15; 79(16):4211-4226. PMID: 31239273; PMCID: PMC6697620.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    26. Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 2019 07; 20(7):835-851. PMID: 31160797; PMCID: PMC6619502.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    27. Zhang L, Yu D. Exosomes in cancer development, metastasis, and immunity. Biochim Biophys Acta Rev Cancer. 2019 04; 1871(2):455-468. PMID: 31047959; PMCID: PMC6542596.
      Citations: 141     Fields:    Translation:HumansAnimalsCells
    28. Yu D. Working together to make AJCR stronger. Am J Cancer Res. 2018; 8(1):1. PMID: 29416915; PMCID: PMC5794716.
      Citations:    
    29. Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest. 2017 12 01; 127(12):4498-4515. PMID: 29130936; PMCID: PMC5707156.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    30. Yang J, Joshi S, Wang Q, Li P, Wang H, Xiong Y, Xiao Y, Wang J, Parker-Thornburg J, Behringer RR, Yu D. 14-3-3? loss leads to neonatal lethality by microRNA-126 downregulation-mediated developmental defects in lung vasculature. Cell Biosci. 2017; 7:58. PMID: 29118970; PMCID: PMC5667492.
      Citations: 2     
    31. Wang X, Yao J, Wang J, Zhang Q, Brady SW, Arun B, Seewaldt VL, Yu D. Targeting Aberrant p70S6K Activation for Estrogen Receptor-Negative Breast Cancer Prevention. Cancer Prev Res (Phila). 2017 Nov; 10(11):641-650. PMID: 28877935; PMCID: PMC5668174.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    32. Gall VA, Philips AV, Qiao N, Clise-Dwyer K, Perakis AA, Zhang M, Clifton GT, Sukhumalchandra P, Ma Q, Reddy SM, Yu D, Molldrem JJ, Peoples GE, Alatrash G, Mittendorf EA. Trastuzumab Increases HER2 Uptake and Cross-Presentation by Dendritic Cells. Cancer Res. 2017 10 01; 77(19):5374-5383. PMID: 28819024; PMCID: PMC5626640.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    33. Joshi S, Yang J, Wang Q, Li P, Wang H, Zhang Q, Xiong Y, Pickering BF, Parker-Thornburg J, Behringer RR, Yu D. 14-3-3? loss impedes oncogene-induced mammary tumorigenesis and metastasis by attenuating oncogenic signaling. Am J Cancer Res. 2017; 7(8):1654-1664. PMID: 28861322; PMCID: PMC5574938.
      Citations: 5     
    34. Zhang C, Lowery FJ, Yu D. Intracarotid Cancer Cell Injection to Produce Mouse Models of Brain Metastasis. J Vis Exp. 2017 02 08; (120). PMID: 28287553; PMCID: PMC5409267.
      Citations: 9     Fields:    Translation:Animals
    35. Zhang C, Yu D. Advances in decoding breast cancer brain metastasis. Cancer Metastasis Rev. 2016 12; 35(4):677-684. PMID: 27873078; PMCID: PMC5215972.
      Citations: 2     Fields:    Translation:HumansAnimals
    36. Lim SO, Li CW, Xia W, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL, Yamaguchi H, Ding Q, Wang Y, Yang Y, Chen CH, Sahin AA, Yu D, Hortobagyi GN, Hung MC. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 2016 Dec 12; 30(6):925-939. PMID: 27866850; PMCID: PMC5171205.
      Citations: 240     Fields:    Translation:HumansAnimalsCells
    37. Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nat Commun. 2016 08 30; 7:12632. PMID: 27572267; PMCID: PMC5013604.
      Citations: 292     Fields:    Translation:HumansAnimalsCells
    38. Chang CC, Zhang C, Zhang Q, Sahin O, Wang H, Xu J, Xiao Y, Zhang J, Rehman SK, Li P, Hung MC, Behbod F, Yu D. Upregulation of lactate dehydrogenase a by 14-3-3? leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. 2016 Jun 07; 7(23):35270-83. PMID: 27150057; PMCID: PMC5085227.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    39. Rahal OM, Nie L, Chan LC, Li CW, Hsu YH, Hsu J, Yu D, Hung MC. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. Am J Cancer Res. 2015; 5(12):3624-34. PMID: 26885451; PMCID: PMC4731636.
      Citations: 1     
    40. Jain S, Wang X, Chang CC, Ibarra-Drendall C, Wang H, Zhang Q, Brady SW, Li P, Zhao H, Dobbs J, Kyrish M, Tkaczyk TS, Ambrose A, Sistrunk C, Arun BK, Richards-Kortum R, Jia W, Seewaldt VL, Yu D. Src Inhibition Blocks c-Myc Translation and Glucose Metabolism to Prevent the Development of Breast Cancer. Cancer Res. 2015 Nov 15; 75(22):4863-75. PMID: 26383165; PMCID: PMC4651709.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    41. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. 14-3-3? turns TGF-?'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015 Feb 09; 27(2):177-92. PMID: 25670079; PMCID: PMC4325275.
      Citations: 88     Fields:    Translation:HumansCells
    42. Brady SW, Zhang J, Tsai MH, Yu D. PI3K-independent mTOR activation promotes lapatinib resistance and IAP expression that can be effectively reversed by mTOR and Hsp90 inhibition. Cancer Biol Ther. 2015; 16(3):402-11. PMID: 25692408; PMCID: PMC4623386.
      Citations: 17     Fields:    Translation:Humans
    43. Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ. HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Mol Oncol. 2015 Mar; 9(3):586-600. PMID: 25435280; PMCID: PMC4815926.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    44. Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC. MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Sci Signal. 2014 Jul 29; 7(336):ra71. PMID: 25074979; PMCID: PMC4161976.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    45. Khotskaya YB, Goverdhan A, Shen J, Ponz-Sarvise M, Chang SS, Hsu MC, Wei Y, Xia W, Yu D, Hung MC. S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. Am J Transl Res. 2014; 6(4):361-76. PMID: 25075253; PMCID: PMC4113498.
      Citations: 26     
    46. Chang Z, Ju H, Ling J, Zhuang Z, Li Z, Wang H, Fleming JB, Freeman JW, Yu D, Huang P, Chiao PJ. Cooperativity of oncogenic K-ras and downregulated p16/INK4A in human pancreatic tumorigenesis. PLoS One. 2014; 9(7):e101452. PMID: 25029561; PMCID: PMC4100754.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    47. Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, Sahin AA, Sood A, Mills GB, Yu D, Hortobagyi GN, Hung MC. Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res. 2014 Sep 01; 74(17):4822-35. PMID: 24970481; PMCID: PMC4154991.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    48. Sahin O, Wang Q, Brady SW, Ellis K, Wang H, Chang CC, Zhang Q, Priya P, Zhu R, Wong ST, Landis MD, Muller WJ, Esteva FJ, Chang J, Yu D. Biomarker-guided sequential targeted therapies to overcome therapy resistance in rapidly evolving highly aggressive mammary tumors. Cell Res. 2014 May; 24(5):542-59. PMID: 24675532; PMCID: PMC4011340.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    49. Brady SW, Zhang J, Seok D, Wang H, Yu D. Enhanced PI3K p110a signaling confers acquired lapatinib resistance that can be effectively reversed by a p110a-selective PI3K inhibitor. Mol Cancer Ther. 2014 Jan; 13(1):60-70. PMID: 24249715; PMCID: PMC3902650.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    50. Rehman SK, Li SH, Wyszomierski SL, Wang Q, Li P, Sahin O, Xiao Y, Zhang S, Xiong Y, Yang J, Wang H, Guo H, Zhang JD, Medina D, Muller WJ, Yu D. 14-3-3? orchestrates mammary tumor onset and progression via miR-221-mediated cell proliferation. Cancer Res. 2014 Jan 01; 74(1):363-373. PMID: 24197133; PMCID: PMC3947305.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    51. Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, Hung MC. Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. PLoS One. 2013; 8(9):e73406. PMID: 24039934; PMCID: PMC3764163.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    52. Zhang S, Huang WC, Zhang L, Zhang C, Lowery FJ, Ding Z, Guo H, Wang H, Huang S, Sahin AA, Aldape KD, Steeg PS, Yu D. SRC family kinases as novel therapeutic targets to treat breast cancer brain metastases. Cancer Res. 2013 Sep 15; 73(18):5764-74. PMID: 23913825; PMCID: PMC3781592.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    53. Ke S, Wang W, Qiu X, Zhang F, Yustein JT, Cameron AG, Zhang S, Yu D, Zou C, Gao X, Lin J, Yallampalli S, Li M. Multiple target-specific molecular agents for detection and image analysis of breast cancer characteristics in mice. Curr Mol Med. 2013 Mar; 13(3):446-58. PMID: 23331017; PMCID: PMC3636521.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    54. Lowery FJ, Yu D. Growth factor signaling in metastasis: current understanding and future opportunities. Cancer Metastasis Rev. 2012 Dec; 31(3-4):479-91. PMID: 22706845.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    55. Wang Q, Li SH, Wang H, Xiao Y, Sahin O, Brady SW, Li P, Ge H, Jaffee EM, Muller WJ, Hortobagyi GN, Yu D. Concomitant targeting of tumor cells and induction of T-cell response synergizes to effectively inhibit trastuzumab-resistant breast cancer. Cancer Res. 2012 Sep 01; 72(17):4417-28. PMID: 22773664; PMCID: PMC3556997.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    56. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 2012 May 25; 149(5):1098-111. PMID: 22632973; PMCID: PMC3586339.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    57. Pickering BF, Yu D, Van Dyke MW. Nucleolin protein interacts with microprocessor complex to affect biogenesis of microRNAs 15a and 16. J Biol Chem. 2011 Dec 23; 286(51):44095-44103. PMID: 22049078; PMCID: PMC3243533.
      Citations: 33     Fields:    Translation:HumansCells
    58. Neal CL, Xu J, Li P, Mori S, Yang J, Neal NN, Zhou X, Wyszomierski SL, Yu D. Overexpression of 14-3-3? in cancer cells activates PI3K via binding the p85 regulatory subunit. Oncogene. 2012 Feb 16; 31(7):897-906. PMID: 21743495; PMCID: PMC3193867.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    59. Morrow PK, Wulf GM, Ensor J, Booser DJ, Moore JA, Flores PR, Xiong Y, Zhang S, Krop IE, Winer EP, Kindelberger DW, Coviello J, Sahin AA, Hortobagyi GN, Yu D, Esteva FJ, Nu?ez R. Phase I/II study of trastuzumab in combination with everolimus (RAD001) in patients with HER2-overexpressing metastatic breast cancer who progressed on trastuzumab-based therapy. J Clin Oncol. 2011 Aug 10; 29(23):3126-32. PMID: 21730275; PMCID: PMC3157979.
      Citations: 81     Fields:    Translation:HumansCTClinical Trials
    60. Kumar A, Gao H, Xu J, Reuben J, Yu D, Mehta K. Evidence that aberrant expression of tissue transglutaminase promotes stem cell characteristics in mammary epithelial cells. PLoS One. 2011; 6(6):e20701. PMID: 21687668; PMCID: PMC3110765.
      Citations: 38     Fields:    Translation:HumansCells
    61. Zhang S, Huang WC, Li P, Guo H, Poh SB, Brady SW, Xiong Y, Tseng LM, Li SH, Ding Z, Sahin AA, Esteva FJ, Hortobagyi GN, Yu D. Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways. Nat Med. 2011 Apr; 17(4):461-9. PMID: 21399647; PMCID: PMC3877934.
      Citations: 235     Fields:    Translation:HumansCells
    62. Jiffar T, Yilmaz T, Lee J, Hanna E, El-Naggar A, Yu D, Myers JN, Kupferman ME. KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma. Oncogene. 2011 Jul 14; 30(28):3163-73. PMID: 21383688; PMCID: PMC3136629.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    63. Zhang C, Yu D. Microenvironment determinants of brain metastasis. Cell Biosci. 2011 Feb 25; 1(1):8. PMID: 21711688; PMCID: PMC3125212.
      Citations: 21     
    64. Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol. 2011 Mar; 13(3):317-23. PMID: 21336307; PMCID: PMC3075845.
      Citations: 368     Fields:    Translation:HumansCells
    65. Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Res. 2010 Oct 01; 70(19):7684-9. PMID: 20841468; PMCID: PMC2948588.
      Citations: 9     Fields:    Translation:AnimalsCells
    66. Esteva FJ, Guo H, Zhang S, Santa-Maria C, Stone S, Lanchbury JS, Sahin AA, Hortobagyi GN, Yu D. PTEN, PIK3CA, p-AKT, and p-p70S6K status: association with trastuzumab response and survival in patients with HER2-positive metastatic breast cancer. Am J Pathol. 2010 Oct; 177(4):1647-56. PMID: 20813970; PMCID: PMC2947262.
      Citations: 133     Fields:    Translation:HumansCells
    67. Kupferman ME, Jiffar T, El-Naggar A, Yilmaz T, Zhou G, Xie T, Feng L, Wang J, Holsinger FC, Yu D, Myers JN. TrkB induces EMT and has a key role in invasion of head and neck squamous cell carcinoma. Oncogene. 2010 Apr 08; 29(14):2047-59. PMID: 20101235; PMCID: PMC3138334.
      Citations: 97     Fields:    Translation:HumansAnimalsCells
    68. Zhao YH, Zhou M, Liu H, Ding Y, Khong HT, Yu D, Fodstad O, Tan M. Upregulation of lactate dehydrogenase A by ErbB2 through heat shock factor 1 promotes breast cancer cell glycolysis and growth. Oncogene. 2009 Oct 22; 28(42):3689-701. PMID: 19668225.
      Citations: 111     Fields:    Translation:HumansAnimalsCells
    69. Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 2009 Jul 02; 28(26):2436-45. PMID: 19448664; PMCID: PMC2748248.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    70. Hannay J, Davis JJ, Yu D, Liu J, Fang B, Pollock RE, Lev D. Isolated limb perfusion: a novel delivery system for wild-type p53 and fiber-modified oncolytic adenoviruses to extremity sarcoma. Gene Ther. 2007 Apr; 14(8):671-81. PMID: 17287860.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    71. Lu J, Yu D. Adenoviral-Vector Based siRNA for Mutant K-ras as a Promising Tool for Lung Cancer Gene Therapy: A License to Kill. Cancer Biol Ther. 2006 Dec; 5(12):1724-5. PMID: 17224631.
      Citations:    Fields:    Translation:HumansCells
    72. Akkiprik M, Nicorici D, Cogdell D, Jia YJ, Hategan A, Tabus I, Yli-Harja O, Y D, Sahin A, Zhang W. Dissection of signaling pathways in fourteen breast cancer cell lines using reverse-phase protein lysate microarray. Technol Cancer Res Treat. 2006 Dec; 5(6):543-51. PMID: 17121430.
      Citations: 8     Fields:    Translation:HumansCells
    73. Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 2006 May; 3(5):269-80. PMID: 16683005.
      Citations: 355     Fields:    Translation:HumansCells
    74. Tan M, Li P, Sun M, Yin G, Yu D. Upregulation and activation of PKC alpha by ErbB2 through Src promotes breast cancer cell invasion that can be blocked by combined treatment with PKC alpha and Src inhibitors. Oncogene. 2006 Jun 01; 25(23):3286-95. PMID: 16407820.
      Citations: 41     Fields:    Translation:HumansCells
    75. Oksvold M, Huitfeldt H, Stang E, Madshus I. Localizing the EGF receptor. Nat Cell Biol. 2002 Feb; 4(2):E22; author reply E22-3. PMID: 11835048.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    76. Yao J, Xiong S, Klos K, Nguyen N, Grijalva R, Li P, Yu D. Multiple signaling pathways involved in activation of matrix metalloproteinase-9 (MMP-9) by heregulin-beta1 in human breast cancer cells. Oncogene. 2001 Dec 06; 20(56):8066-74. PMID: 11781819.
      Citations: 61     Fields:    Translation:HumansCells
    77. Yu D. Mechanisms of ErbB2-mediated paclitaxel resistance and trastuzumab-mediated paclitaxel sensitization in ErbB2-overexpressing breast cancers. Semin Oncol. 2001 Oct; 28(5 Suppl 16):12-7. PMID: 11706391.
      Citations: 13     Fields:    Translation:HumansAnimals
    78. Zhan M, Yu D, Lang A, Li L, Pollock RE. Wild type p53 sensitizes soft tissue sarcoma cells to doxorubicin by down-regulating multidrug resistance-1 expression. Cancer. 2001 Sep 15; 92(6):1556-66. PMID: 11745235.
      Citations: 15     Fields:    Translation:Cells
    79. Makino K, Yu D, Hung MC. Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis. Oncogene. 2001 May 03; 20(20):2537-43. PMID: 11420663.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    80. Xiong S, Grijalva R, Zhang L, Nguyen NT, Pisters PW, Pollock RE, Yu D. Up-regulation of vascular endothelial growth factor in breast cancer cells by the heregulin-beta1-activated p38 signaling pathway enhances endothelial cell migration. Cancer Res. 2001 Feb 15; 61(4):1727-32. PMID: 11245489.
      Citations: 22     Fields:    Translation:HumansCells
    81. Ueno NT, Yu D, Hung MC. E1A: tumor suppressor or oncogene? Preclinical and clinical investigations of E1A gene therapy. Breast Cancer. 2001; 8(4):285-93. PMID: 11791119.
      Citations: 10     Fields:    Translation:HumansAnimals
    82. Yu D, Hung MC. Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene. 2000 Dec 11; 19(53):6115-21. PMID: 11156524.
      Citations: 142     Fields:    Translation:HumansAnimals
    83. Grothey A, Hashizume R, Ji H, Tubb BE, Patrick CW, Yu D, Mooney EE, McCrea PD. C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines. Oncogene. 2000 Oct 05; 19(42):4864-75. PMID: 11039904.
      Citations: 43     Fields:    Translation:HumansCells
    84. Yu D, Hung MC. Role of erbB2 in breast cancer chemosensitivity. Bioessays. 2000 Jul; 22(7):673-80. PMID: 10878580.
      Citations: 25     Fields:    Translation:Humans
    85. Zhang L, Yu D, Hu M, Xiong S, Lang A, Ellis LM, Pollock RE. Wild-type p53 suppresses angiogenesis in human leiomyosarcoma and synovial sarcoma by transcriptional suppression of vascular endothelial growth factor expression. Cancer Res. 2000 Jul 01; 60(13):3655-61. PMID: 10910082.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    86. Milas M, Yu D, Lang A, Ge T, Feig B, El-Naggar AK, Pollock RE. Adenovirus-mediated p53 gene therapy inhibits human sarcoma tumorigenicity. Cancer Gene Ther. 2000 Mar; 7(3):422-9. PMID: 10766348.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    87. Ueno NT, Bartholomeusz C, Herrmann JL, Estrov Z, Shao R, Andreeff M, Price J, Paul RW, Anklesaria P, Yu D, Hung MC. E1A-mediated paclitaxel sensitization in HER-2/neu-overexpressing ovarian cancer SKOV3.ip1 through apoptosis involving the caspase-3 pathway. Clin Cancer Res. 2000 Jan; 6(1):250-9. PMID: 10656456.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    88. Feig BW, Lu X, Hunt KK, Shan Q, Yu D, Pollock R, Chiao P. Inhibition of the transcription factor nuclear factor-kappa B by adenoviral-mediated expression of I kappa B alpha M results in tumor cell death. Surgery. 1999 Aug; 126(2):399-405. PMID: 10455913.
      Citations: 4     Fields:    Translation:HumansCells
    89. Tan M, Grijalva R, Yu D. Heregulin beta1-activated phosphatidylinositol 3-kinase enhances aggregation of MCF-7 breast cancer cells independent of extracellular signal-regulated kinase. Cancer Res. 1999 Apr 01; 59(7):1620-5. PMID: 10197638.
      Citations: 19     Fields:    Translation:HumansCells
    90. Yu D, Jing T, Liu B, Yao J, Tan M, McDonnell TJ, Hung MC. Overexpression of ErbB2 blocks Taxol-induced apoptosis by upregulation of p21Cip1, which inhibits p34Cdc2 kinase. Mol Cell. 1998 Nov; 2(5):581-91. PMID: 9844631.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    91. Milas M, Yu D, Pollock RE. Advances in the understanding of human soft tissue sarcomas: molecular biology and therapeutic strategies (Review). Oncol Rep. 1998 Sep-Oct; 5(5):1275-9. PMID: 9683850.
      Citations: 1     Fields:    Translation:Humans
    92. Yu D. The role of oncogenes in drug resistance. Cytotechnology. 1998 Sep; 27(1-3):283-92. PMID: 19002799; PMCID: PMC3449565.
      Citations: 3     Fields:    
    93. Pollock R, Lang A, Ge T, Sun D, Tan M, Yu D. Wild-type p53 and a p53 temperature-sensitive mutant suppress human soft tissue sarcoma by enhancing cell cycle control. Clin Cancer Res. 1998 Aug; 4(8):1985-94. PMID: 9717829.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    94. Yu D, Hung MC. The erbB2 gene as a cancer therapeutic target and the tumor- and metastasis-suppressing function of E1A. Cancer Metastasis Rev. 1998 Jun; 17(2):195-202. PMID: 9770116.
      Citations: 5     Fields:    Translation:HumansAnimals
    95. Milas M, Yu D, Sun D, Pollock RE. Telomerase activity of sarcoma cell lines and fibroblasts is independent of p53 status. Clin Cancer Res. 1998 Jun; 4(6):1573-9. PMID: 9626480.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    96. Yu D, Liu B, Jing T, Sun D, Price JE, Singletary SE, Ibrahim N, Hortobagyi GN, Hung MC. Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol. Oncogene. 1998 Apr 23; 16(16):2087-94. PMID: 9572489.
      Citations: 23     Fields:    Translation:HumansCells
    97. Yao J, Pollock RE, Lang A, Tan M, Pisters PW, Goodrich D, El-Naggar A, Yu D. Infrequent mutation of the p16/MTS1 gene and overexpression of cyclin-dependent kinase 4 in human primary soft-tissue sarcoma. Clin Cancer Res. 1998 Apr; 4(4):1065-70. PMID: 9563903.
      Citations: 6     Fields:    Translation:HumansAnimals
    98. Milas M, Feig B, Yu D, Oriuchi N, Cromeens D, Ge T, Wong FC, Kim EE, Pollock R. Isolated limb perfusion in the sarcoma-bearing rat: a novel preclinical gene delivery system. Clin Cancer Res. 1997 Dec; 3(12 Pt 1):2197-203. PMID: 9815615.
      Citations: 3     Fields:    Translation:AnimalsCells
    99. Brader KR, Wolf JK, Hung MC, Yu D, Crispens MA, van Golen KL, Price JE. Adenovirus E1A expression enhances the sensitivity of an ovarian cancer cell line to multiple cytotoxic agents through an apoptotic mechanism. Clin Cancer Res. 1997 Nov; 3(11):2017-24. PMID: 9815592.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    100. Liu B, Sun D, Xia W, Hung MC, Yu D. Cross-reactivity of C219 anti-p170(mdr-1) antibody with p185(c-erbB2) in breast cancer cells: cautions on evaluating p170(mdr-1) J Natl Cancer Inst. 1997 Oct 15; 89(20):1524-9. PMID: 9337349.
      Citations: 9     Fields:    Translation:HumansCells
    101. Ueno NT, Yu D, Hung MC. Chemosensitization of HER-2/neu-overexpressing human breast cancer cells to paclitaxel (Taxol) by adenovirus type 5 E1A. Oncogene. 1997 Aug 18; 15(8):953-60. PMID: 9285690.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    102. Chen H, Yu D, Chinnadurai G, Karunagaran D, Hung MC. Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu. Oncogene. 1997 Apr 24; 14(16):1965-71. PMID: 9150363.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    103. Tan M, Yao J, Yu D. Overexpression of the c-erbB-2 gene enhanced intrinsic metastasis potential in human breast cancer cells without increasing their transformation abilities. Cancer Res. 1997 Mar 15; 57(6):1199-205. PMID: 9067293.
      Citations: 62     Fields:    Translation:HumansAnimals
    104. Singletary SE, Dhingra K, Yu DH. New strategies in locally advanced breast cancer. Cancer Treat Res. 1997; 90:253-71. PMID: 9367088.
      Citations:    Fields:    Translation:Humans
    105. Yu D, Liu B, Tan M, Li J, Wang SS, Hung MC. Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms. Oncogene. 1996 Sep 19; 13(6):1359-65. PMID: 8808711.
      Citations: 36     Fields:    Translation:HumansCells
    106. Pollock RE, Lang A, Luo J, El-Naggar AK, Yu D. Soft tissue sarcoma metastasis from clonal expansion of p53 mutated tumor cells. Oncogene. 1996 May 02; 12(9):2035-9. PMID: 8649865.
      Citations: 9     Fields:    Translation:HumansCells
    107. Yu D, Matin A, Xia W, Sorgi F, Huang L, Hung MC. Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu. Oncogene. 1995 Oct 05; 11(7):1383-8. PMID: 7478560.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    108. Gum R, Wang SW, Lengyel E, Yu D, Hung MC, Juarez J, Boyd D. Up-regulation of urokinase-type plasminogen activator expression by the HER2/neu proto-oncogene. Anticancer Res. 1995 Jul-Aug; 15(4):1167-72. PMID: 7653995.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    109. Hung MC, Matin A, Zhang Y, Xing X, Sorgi F, Huang L, Yu D. HER-2/neu-targeting gene therapy--a review. Gene. 1995 Jun 14; 159(1):65-71. PMID: 7607574.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    110. Zhang Y, Yu D, Xia W, Hung MC. HER-2/neu-targeting cancer therapy via adenovirus-mediated E1A delivery in an animal model. Oncogene. 1995 May 18; 10(10):1947-54. PMID: 7761095.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    111. Tsai CM, Yu D, Chang KT, Wu LH, Perng RP, Ibrahim NK, Hung MC. Enhanced chemoresistance by elevation of p185neu levels in HER-2/neu-transfected human lung cancer cells. J Natl Cancer Inst. 1995 May 03; 87(9):682-4. PMID: 7538595.
      Citations: 16     Fields:    Translation:HumansCells
    112. Yu D, Wang SS, Dulski KM, Tsai CM, Nicolson GL, Hung MC. c-erbB-2/neu overexpression enhances metastatic potential of human lung cancer cells by induction of metastasis-associated properties. Cancer Res. 1994 Jun 15; 54(12):3260-6. PMID: 7911396.
      Citations: 34     Fields:    Translation:HumansAnimals
    113. Yu D, Matin A, Hinds PW, Hung MC. Transcriptional regulation of neu by RB and E1A in rat-1 cells. Cell Growth Differ. 1994 Apr; 5(4):431-8. PMID: 8043517.
      Citations: 2     Fields:    Translation:AnimalsCells
    114. Yu D, Shi D, Scanlon M, Hung MC. Reexpression of neu-encoded oncoprotein counteracts the tumor-suppressing but not the metastasis-suppressing function of E1A. Cancer Res. 1993 Dec 01; 53(23):5784-90. PMID: 7902209.
      Citations: 3     Fields:    Translation:AnimalsCells
    115. Yu D, Wolf JK, Scanlon M, Price JE, Hung MC. Enhanced c-erbB-2/neu expression in human ovarian cancer cells correlates with more severe malignancy that can be suppressed by E1A. Cancer Res. 1993 Feb 15; 53(4):891-8. PMID: 8094034.
      Citations: 99     Fields:    Translation:HumansAnimalsCells
    116. Yu D, Hamada J, Zhang H, Nicolson GL, Hung MC. Mechanisms of c-erbB2/neu oncogene-induced metastasis and repression of metastatic properties by adenovirus 5 E1A gene products. Oncogene. 1992 Nov; 7(11):2263-70. PMID: 1359495.
      Citations: 19     Fields:    Translation:Animals
    117. Yu D, Matin A, Hung MC. The retinoblastoma gene product suppresses neu oncogene-induced transformation via transcriptional repression of neu. J Biol Chem. 1992 May 25; 267(15):10203-6. PMID: 1350277.
      Citations: 8     Fields:    Translation:AnimalsCells
    118. Chan JC, Scanlon M, Zhang HZ, Jia LB, Yu DH, Hung MC, French M, Eastman EM. Molecular cloning and characterization of v-mos-activated transformation-associated proteins. J Biol Chem. 1992 Jan 15; 267(2):1099-103. PMID: 1370458.
      Citations: 3     Fields:    Translation:AnimalsCells
    119. Shi D, He G, Cao S, Pan W, Zhang HZ, Yu D, Hung MC. Overexpression of the c-erbB-2/neu-encoded p185 protein in primary lung cancer. Mol Carcinog. 1992; 5(3):213-8. PMID: 1350198.
      Citations: 9     Fields:    Translation:Humans
    120. Yu DH, Hung MC. Expression of activated rat neu oncogene is sufficient to induce experimental metastasis in 3T3 cells. Oncogene. 1991 Nov; 6(11):1991-6. PMID: 1682865.
      Citations: 19     Fields:    Translation:AnimalsCells
    121. Yu DH, Scorsone K, Hung MC. Adenovirus type 5 E1A gene products act as transformation suppressors of the neu oncogene. Mol Cell Biol. 1991 Mar; 11(3):1745-50. PMID: 1671710; PMCID: PMC369488.
      Citations: 13     Fields:    Translation:AnimalsCells
    122. Yu D, Suen TC, Yan DH, Chang LS, Hung MC. Transcriptional repression of the neu protooncogene by the adenovirus 5 E1A gene products. Proc Natl Acad Sci U S A. 1990 Jun; 87(12):4499-503. PMID: 1972274; PMCID: PMC54143.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    123. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. American Journal of Cancer Research. 5:3624-3634.
    124. Erratum. Journal of Biological Chemistry. 280:22555.
    125. Erratum. Nature Cell Biology. 13:1466.
    126. Downregulation of GLUT4 contributes to effective intervention of estrogen receptor-negative/HER2-overexpressing early stage breast disease progression by lapatinib. American Journal of Cancer Research. 6:981-995.
    127. The role of PTEN and its signalling pathways, including AKT, in breast cancer; an assessment of relationships with other prognostic factors and with outcome. Breast Diseases. 16:53-54.
    128. HER2-positive breast cancers make more CXCR4 which helps them invade and metastasize. Cancer Biology and Therapy. 3:1195-1196.
    129. Heregulin-HER3-HER2 signaling promotes matrix metalloproteinase-dependent blood-brain-barrier transendothelial migration of human breast cancer cell lines. Oncotarget. 6:3932-3946.
    130. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. 7:35270-35283.
    131. Advances in decoding breast cancer brain metastasis. Cancer and Metastasis Reviews. 35:677-684.
    132. Erratum. Nature Cell Biology. 13:1467.
    133. S6k1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. American Journal of Translational Research. 6:361-376.
    134. Src inhibition blocks c-Myc translation and glucose metabolism to prevent the development of breast cancer. Cancer Research. 75:4863-4875.
    135. High-resolution fiber-optic microendoscopy for in situ cellular imaging. Journal of Visualized Experiments.
    136. Erratum. Cell. 151:913-914.
    137. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nature Communications. 7.
    138. Targeting the EGFR family of receptor tyrosine kinases. 843-853.
    139. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology. 608.
    140. Erratum. Breast Cancer Research and Treatment. 135:925.
    141. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 30:925-939.
    142. PTEN key to Herceptin response in Her2-positive breast cancer. Cancer Biology and Therapy. 3:796.
    143. Mechanisms of breast cancer resistance to chemotherapy. 783-803.
    144. Fluoxetine induces cytotoxic endoplasmic reticulum stress and autophagy in triple negative breast cancer. World Journal of Clinical Oncology. 6:299-311.
    145. Brain metastasis. Biochimica et Biophysica Acta - Reviews on Cancer. 1867:49-57.
    146. Microtubule-associated protein tau. Breast Diseases. 16:374-375.
    147. Neural Stem Cells Secreting Anti-HER2 Antibody Improve Survival in a Preclinical Model of HER2 Overexpressing Breast Cancer Brain Metastases. Stem Cells. 33:2985-2994.
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