Header Logo

MIEN-CHIE HUNG

TitleProfessor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
vCardDownload vCard

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Liu Y, Yang Z, Wang S, Miao R, Chang CM, Zhang J, Zhang X, Hung MC, Hou J. Nuclear PD-L1 compartmentalization suppresses tumorigenesis and overcomes immunocheckpoint therapy resistance in mice via histone macroH2A1. J Clin Invest. 2024 Nov 15; 134(22). PMID: 39545415; PMCID: PMC11563670.
      Citations:    Fields:    Translation:HumansAnimalsCells
    2. Liao YC, Wang LH, Hung MC, Cheng TC, Lin YC, Chang J, Tu SH, Wu CH, Yen Y, Hsieh YC, Chen LC, Ho YS. Investigation of the a9-nicotinic receptor single nucleotide polymorphisms induced oncogenic properties and molecular mechanisms in breast cancer. Hum Mol Genet. 2024 11 08; 33(22):1948-1965. PMID: 39251229.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Liu S, Yang S, Xu M, Zhou Q, Weng J, Hu Z, Xu M, Xu W, Yi Y, Shi Y, Dong Q, Hung MC, Ren N, Zhou C. WWOX tuning of oleic acid signaling orchestrates immunosuppressive macrophage polarization and sensitizes hepatocellular carcinoma to immunotherapy. J Immunother Cancer. 2024 Nov 05; 12(11). PMID: 39500530; PMCID: PMC11552608.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Xie P, Guo L, Yu Q, Zhao Y, Yu M, Wang H, Wu M, Xu W, Xu M, Zhu XD, Xu Y, Xiao YS, Huang C, Zhou J, Fan J, Hung MC, Sun H, Ye QH, Zhang B, Li H. ACE2 Enhances Sensitivity to PD-L1 Blockade by Inhibiting Macrophage-Induced Immunosuppression and Angiogenesis. Cancer Res. 2024 Nov 04. PMID: 39495239.
      Citations:    Fields:    
    5. Chang LC, Chiang SK, Chen SE, Hung MC. Exploring paraptosis as a therapeutic approach in cancer treatment. J Biomed Sci. 2024 Nov 04; 31(1):101. PMID: 39497143; PMCID: PMC11533606.
      Citations:    Fields:    Translation:HumansCells
    6. Saito Y, Xiao Y, Yao J, Li Y, Liu W, Yuzhalin AE, Shyu YM, Li H, Yuan X, Li P, Zhang Q, Li Z, Wei Y, Yin X, Zhao J, Kariminia SM, Wu YC, Wang J, Yang J, Xia W, Sun Y, Jho EH, Chiao PJ, Hwang RF, Ying H, Wang H, Zhao Z, Maitra A, Hung MC, DePinho RA, Yu D. Targeting a chemo-induced adaptive signaling circuit confers therapeutic vulnerabilities in pancreatic cancer. Cell Discov. 2024 Oct 29; 10(1):109. PMID: 39468013; PMCID: PMC11519973.
      Citations:    
    7. Li CF, Bai LY, Wei Y, Lee HH, Yang R, Yao J, Wang H, Wang YN, Chang WC, Shen YC, Wang SC, Chou CW, Fu J, Ling J, Chu YY, Chiu CF, Wang M, Yu D, Chiao PJ, Liang H, Maitra A, Ying H, Hung MC. All-trans retinoic acid-mediated ADAR1 degradation synergizes with PD-1 blockade to suppress pancreatic cancer. bioRxiv. 2024 Oct 23. PMID: 39484589; PMCID: PMC11527022.
      Citations:    
    8. Lin YW, Cheng SW, Liu WC, Zailani H, Wu SK, Hung MC, Su KP. Chemogenetic targeting TRPV1 in obesity-induced depression: Unveiling therapeutic potential of eicosapentaenoic acid and acupuncture. Brain Behav Immun. 2024 Oct 23; 123:771-783. PMID: 39454693.
      Citations:    Fields:    
    9. Yuzhalin AE, Lowery FJ, Saito Y, Yuan X, Yao J, Duan Y, Ding J, Acharya S, Zhang C, Fajardo A, Chen HN, Wei Y, Sun Y, Zhang L, Xiao Y, Li P, Lorenzi PL, Huse JT, Fan H, Zhao Z, Hung MC, Yu D. Astrocyte-induced Cdk5 expedites breast cancer brain metastasis by suppressing MHC-I expression to evade immune recognition. Nat Cell Biol. 2024 Oct; 26(10):1773-1789. PMID: 39304713.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    10. Lee W, Lin SL, Chiang CS, Chen JY, Chieng WW, Huang SR, Chang TY, Linju Yen B, Hung MC, Chang KC, Lee HT, Jeng LB, Shyu WC. Role of HIF-1a-Activated IL-22/IL-22R1/Bmi1 Signaling Modulates the Self-Renewal of Cardiac Stem Cells in Acute Myocardial Ischemia. Stem Cell Rev Rep. 2024 Nov; 20(8):2194-2214. PMID: 39264501; PMCID: PMC11554697.
      Citations:    Fields:    Translation:AnimalsCells
    11. Wang WJ, Tang HT, Ou SC, Shen WJ, Chen CY, Li YC, Chang SY, Chang WC, Hsueh PR, Huang ST, Hung MC, Tang HT, Ou SC, Chang WC, Huang ST, Hung MC. Novel SARS-CoV-2 inhibition properties of the anti-cancer Kang Guan Recipe herbal formula. Cancer Lett. 2024 Nov 01; 604:217198. PMID: 39197583.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Chi XX, Ye P, Cao NQ, Hwang WL, Cha JH, Hung MC, Hsu KW, Yan XW, Yang WH. PPIH as a poor prognostic factor increases cell proliferation and m6A RNA methylation in hepatocellular carcinoma. Am J Cancer Res. 2024; 14(8):3733-3756. PMID: 39267679; PMCID: PMC11387852.
      Citations:    
    13. Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B, Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024 Aug 02; 14(8):1476-1495. PMID: 38552003; PMCID: PMC11296921.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Chen Z, Yu M, Zhang B, Jin L, Yu Q, Liu S, Zhou B, Yan J, Zhang W, Li X, Xu Y, Xiao Y, Zhou J, Fan J, Hung MC, Ye Q, Li H, Guo L. SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion. Oncoimmunology. 2024; 13(1):2376264. PMID: 38988824; PMCID: PMC11236293.
      Citations:    Fields:    Translation:HumansAnimalsCells
    15. Feng LL, Bie SY, Deng ZH, Bai SM, Shi J, Qin CL, Liu HL, Li JX, Chen WY, Zhou JY, Jiao CM, Ma Y, Qiu MB, Ai HS, Zheng J, Hung MC, Wang YL, Wan XB, Fan XJ. Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2322972121. PMID: 38968116; PMCID: PMC11252754.
      Citations:    Fields:    Translation:HumansCells
    16. Liu CH, Shen PC, Lin WJ, Liu HC, Tsai MH, Huang TY, Chen IC, Lai YL, Wang YD, Hung MC, Cheng WC. LipidSig 2.0: integrating lipid characteristic insights into advanced lipidomics data analysis. Nucleic Acids Res. 2024 Jul 05; 52(W1):W390-W397. PMID: 38709887; PMCID: PMC11223864.
      Citations: 1     Fields:    
    17. Yamaguchi H, Hsu JM, Sun L, Wang SC, Hung MC. Advances and prospects of biomarkers for immune checkpoint inhibitors. Cell Rep Med. 2024 Jul 16; 5(7):101621. PMID: 38906149; PMCID: PMC11293349.
      Citations: 5     Fields:    Translation:HumansAnimals
    18. Le UNP, Chang YJ, Lu CH, Chen Y, Su WC, Chao ST, Baltina LA, Petrova SF, Li SR, Hung MC, Lai MMC, Baltina LA, Lin CW. Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants. Antiviral Res. 2024 07; 227:105920. PMID: 38821317.
      Citations:    Fields:    Translation:HumansAnimalsCells
    19. Chen CY, Wang WJ, Wu CS, Wang SC, Chang WC, Hung MC. Tannic acids and proanthocyanidins in tea inhibit SARS-CoV-2 variants infection. Am J Cancer Res. 2024; 14(5):2555-2569. PMID: 38859869; PMCID: PMC11162682.
      Citations: 1     
    20. Lin CH, Chin Y, Zhou M, Sobol RW, Hung MC, Tan M. Protein lipoylation: mitochondria, cuproptosis, and beyond. Trends Biochem Sci. 2024 Aug; 49(8):729-744. PMID: 38714376.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    21. Fu J, Ling J, Li CF, Tsai CL, Yin W, Hou J, Chen P, Cao Y, Kang Y, Sun Y, Xia X, Jiang Z, Furukawa K, Lu Y, Wu M, Huang Q, Yao J, Hawke DH, Pan BF, Zhao J, Huang J, Wang H, Bahassi EIM, Stambrook PJ, Huang P, Fleming JB, Maitra A, Tainer JA, Hung MC, Lin C, Chiao PJ. Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nat Commun. 2024 Apr 11; 15(1):3149. PMID: 38605037; PMCID: PMC11009390.
      Citations:    Fields:    Translation:HumansAnimals
    22. Chen HH, Yu HI, Chang JJ, Li CW, Yang MH, Hung MC, Tarn WY. DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1. Cell Rep. 2024 Mar 26; 43(3):113937. PMID: 38489268.
      Citations: 1     Fields:    Translation:HumansCells
    23. Jabbarzadeh Kaboli P, Chen HF, Babaeizad A, Roustai Geraylow K, Yamaguchi H, Hung MC. Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer. Cancer Lett. 2024 Apr 28; 588:216780. PMID: 38462033.
      Citations: 2     Fields:    Translation:HumansCells
    24. Xie P, Yu M, Zhang B, Yu Q, Zhao Y, Wu M, Jin L, Yan J, Zhou B, Liu S, Li X, Zhou C, Zhu X, Huang C, Xu Y, Xiao Y, Zhou J, Fan J, Hung MC, Ye Q, Guo L, Li H, Yu Q, Wu M, Yan J. CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma. J Hepatol. 2024 Jul; 81(1):93-107. PMID: 38403027.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    25. Liu C, Zhou C, Xia W, Zhou Y, Qiu Y, Weng J, Zhou Q, Chen W, Wang YN, Lee HH, Wang SC, Kuang M, Yu D, Ren N, Hung MC. Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma. Nat Commun. 2024 Feb 02; 15(1):1009. PMID: 38307859; PMCID: PMC10837126.
      Citations:    Fields:    Translation:HumansAnimalsCells
    26. Huang YK, Cheng WC, Kuo TT, Yang JC, Wu YC, Wu HH, Lo CC, Hsieh CY, Wong SC, Lu CH, Wu WL, Liu SJ, Li YC, Lin CC, Shen CN, Hung MC, Lin JT, Yeh CC, Sher YP. Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nat Cancer. 2024 Mar; 5(3):400-419. PMID: 38267627.
      Citations:    Fields:    Translation:Humans
    27. Chen HF, Chang CT, Hsu KW, Peng PH, Lai JC, Hung MC, Wu KJ. Epigenetic regulation of asymmetric cell division by the LIBR-BRD4 axis. Nucleic Acids Res. 2024 Jan 11; 52(1):154-165. PMID: 37986225; PMCID: PMC10783485.
      Citations:    Fields:    
    28. Liu CH, Lai YL, Shen PC, Liu HC, Tsai MH, Wang YD, Lin WJ, Chen FH, Li CY, Wang SC, Hung MC, Cheng WC. DriverDBv4: a multi-omics integration database for cancer driver gene research. Nucleic Acids Res. 2024 Jan 05; 52(D1):D1246-D1252. PMID: 37956338; PMCID: PMC10767848.
      Citations:    Fields:    Translation:Humans
    29. Chang CW, Wang S, Huang J, Zeng S, Zhang X, Hung MC, Hou J. Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024 Jan 02; 134(1). PMID: 37883181; PMCID: PMC10760963.
      Citations: 1     Fields:    Translation:HumansAnimals
    30. Yamaguchi H, Chang LC, Chang OS, Chen YF, Hsiao YC, Wu CS, Hung MC. MRCK as a Potential Target for Claudin-Low Subtype of Breast Cancer. Int J Biol Sci. 2024; 20(1):1-14. PMID: 38164185; PMCID: PMC10750295.
      Citations: 1     Fields:    Translation:HumansCells
    31. Chou WC, Chen WT, Kuo CT, Chang YM, Lu YS, Li CW, Hung MC, Shen CY. Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer. Cell Rep. 2024 01 23; 43(1):113641. PMID: 38165805.
      Citations: 2     Fields:    Translation:Animals
    32. Wu CS, Li YC, Peng SL, Chen CY, Chen HF, Hsueh PR, Wang WJ, Liu YY, Jiang CL, Chang WC, Wang SC, Hung MC. Coffee as a dietary strategy to prevent SARS-CoV-2 infection. Cell Biosci. 2023 Nov 14; 13(1):210. PMID: 37964389; PMCID: PMC10644613.
      Citations:    
    33. Su WC, Chen ZY, Chang YS, Jeng KS, Le UNP, Chou YC, Kuo LL, Melano I, Wang WJ, Song YC, Li SR, Hung MC, Lai MMC, Lin CW. Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization. Antiviral Res. 2023 12; 220:105744. PMID: 37944823.
      Citations:    Fields:    Translation:HumansCells
    34. Dabrell SN, Li YC, Yamaguchi H, Chen HF, Hung MC. Herbal Compounds Dauricine and Isoliensinine Impede SARS-CoV-2 Viral Entry. Biomedicines. 2023 Oct 27; 11(11). PMID: 38001915; PMCID: PMC10669532.
      Citations:    
    35. Lee PC, Kumar V, Sivakumar G, Tseng TY, Li YC, Jiang YC, Hsiao YC, Lin HW, Chang CS, Hung MC. Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers. Am J Cancer Res. 2023; 13(10):4693-4707. PMID: 37970360; PMCID: PMC10636659.
      Citations:    
    36. Koller P, Baran N, Harutyunyan K, Cavazos A, Mallampati S, Chin RL, Jiang Z, Sun X, Lee HH, Hsu JL, Williams P, Huang X, Curran MA, Hung MC, Konopleva M. PD-1 blockade in combination with dasatinib potentiates induction of anti-acute lymphocytic leukemia immunity. J Immunother Cancer. 2023 10; 11(10). PMID: 37793852; PMCID: PMC10551962.
      Citations:    Fields:    Translation:HumansAnimals
    37. Melano I, Cheng WC, Kuo LL, Liu YM, Chou YC, Hung MC, Lai MMC, Sher YP, Su WC. A disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expression. Microbiol Spectr. 2023 Sep 15; e0385422. PMID: 37713503; PMCID: PMC10581035.
      Citations: 1     Fields:    
    38. Yamaguchi H, Hung MC. PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to shape anti-tumor immunity. Cancer Cell. 2023 Oct 09; 41(10):1701-1704. PMID: 37683640.
      Citations:    Fields:    
    39. Chen HF, Wang WJ, Chen CY, Chang WC, Hsueh PR, Peng SL, Wu CS, Chen Y, Huang HY, Shen WJ, Wang SC, Hung MC. The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2. Elife. 2023 08 29; 12. PMID: 37642993; PMCID: PMC10465125.
      Citations: 2     Fields:    Translation:HumansCells
    40. Hou J, Li T, Hsu JM, Zhang X, Hung MC. Gasdermins and cancers. Semin Immunol. 2023 11; 70:101833. PMID: 37647772.
      Citations: 2     Fields:    Translation:Humans
    41. Sun X, Wang WJ, Lang J, Yang R, Shen WJ, Sun L, Hsu JM, Chan LC, Li CW, Xia W, Ke B, Yao G, Huang K, Lee PC, Koller PB, Hung MC. Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity. Int J Biol Sci. 2023; 19(14):4644-4656. PMID: 37781042; PMCID: PMC10535704.
      Citations: 1     Fields:    Translation:HumansAnimals
    42. Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung MC, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 08 08; 35(8):1457-1473.e13. PMID: 37329887; PMCID: PMC10712687.
      Citations: 2     Fields:    Translation:AnimalsCells
    43. Wang YN, Lee HH, Jiang Z, Chan LC, Hortobagyi GN, Yu D, Hung MC. Ribonuclease 1 Enhances Antitumor Immunity against Breast Cancer by Boosting T cell Activation. Int J Biol Sci. 2023; 19(10):2957-2973. PMID: 37416781; PMCID: PMC10321278.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    44. Cho J, Min HY, Lee HJ, Hyun SY, Sim JY, Noh M, Hwang SJ, Park SH, Boo HJ, Lee HJ, Hong S, Park RW, Shin YK, Hung MC, Lee HY. RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. J Clin Invest. 2023 May 15; 133(10). PMID: 37183821; PMCID: PMC10178829.
      Citations: 1     Fields:    Translation:HumansCells
    45. Hong X, Hsieh MT, Tseng TY, Lin HY, Chang HC, Yau ST, Cheng WC, Liao HH, Wu CY, Liu AA, Kuo SC, Hung MC, Lee PC, Ke B, Wu MM, Huang KY, Yang PC. Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma. J Biol Chem. 2023 06; 299(6):104814. PMID: 37178919; PMCID: PMC10276293.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    46. Radaram B, Glazer SE, Yang P, Li CW, Hung MC, Gammon ST, Alauddin M, Piwnica-Worms D. Evaluation of 89Zr-Labeled Anti-PD-L1 Monoclonal Antibodies Using DFO and Novel HOPO Analogues as Chelating Agents for Immuno-PET. ACS Omega. 2023 May 16; 8(19):17181-17194. PMID: 37214681; PMCID: PMC10193402.
      Citations: 1     
    47. Hao X, Shen Y, Chen N, Zhang W, Valverde E, Wu L, Chan HL, Xu Z, Yu L, Gao Y, Bado I, Michie LN, Rivas CH, Dominguez LB, Aguirre S, Pingel BC, Wu YH, Liu F, Ding Y, Edwards DG, Liu J, Alexander A, Ueno NT, Hsueh PR, Tu CY, Liu LC, Chen SH, Hung MC, Lim B, Zhang XH. Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. Cell Stem Cell. 2023 05 04; 30(5):648-664.e8. PMID: 37146584; PMCID: PMC10165729.
      Citations: 2     Fields:    Translation:HumansCells
    48. Shie MY, Fang HY, Kan KW, Ho CC, Tu CY, Lee PC, Hsueh PR, Chen CH, Lee AK, Tien N, Chen JX, Shen YC, Chang JG, Shen YF, Lin TJ, Wang B, Hung MC, Cho DY, Chen YW. Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics. Adv Sci (Weinh). 2023 06; 10(16):e2206603. PMID: 37085943; PMCID: PMC10238206.
      Citations: 4     Fields:    Translation:HumansCells
    49. Nie L, Wang YN, Hsu JM, Hou J, Chu YY, Chan LC, Huo L, Wei Y, Deng R, Tang J, Hsu YH, Ko HW, Lim SO, Huang K, Chen MK, Chiu TJ, Cheng CC, Fang YF, Li CW, Goverdhan A, Wu HJ, Lee CC, Wang WL, Hsu J, Chiao P, Wang SC, Hung MC. Nuclear export signal mutation of epidermal growth factor receptor enhances malignant phenotypes of cancer cells. Am J Cancer Res. 2023; 13(4):1209-1239. PMID: 37168336; PMCID: PMC10164793.
      Citations: 1     
    50. Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J, Hung MC, Sood AK. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2023 03 28; 42(3). PMID: 37274180; PMCID: PMC10237679.
      Citations:    Fields:    
    51. Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nat Commun. 2023 03 27; 14(1):1694. PMID: 36973285; PMCID: PMC10042811.
      Citations:    Fields:    Translation:Humans
    52. Wang HC, Chang WC, Lee DY, Li XG, Hung MC. IRG1/Itaconate induces metabolic reprogramming to suppress ER-positive breast cancer cell growth. Am J Cancer Res. 2023; 13(3):1067-1081. PMID: 37034222; PMCID: PMC10077032.
      Citations:    
    53. Zhou C, Weng J, Liu C, Liu S, Hu Z, Xie X, Gao D, Zhou Q, Sun J, Xu R, Li H, Shen Y, Yi Y, Shi Y, Sheng X, Dong Q, Hung MC, Ren N. Disruption of SLFN11 Deficiency-Induced CCL2 Signaling and Macrophage M2 Polarization Potentiates Anti-PD-1 Therapy Efficacy in Hepatocellular Carcinoma. Gastroenterology. 2023 06; 164(7):1261-1278. PMID: 36863689.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    54. Liu H, Ou J, Hung MC, Chen X. Immune checkpoint blockades therapy of melanoma. Sci Bull (Beijing). 2023 02 26; 68(4):356-358. PMID: 36774302.
      Citations:    Fields:    Translation:Humans
    55. Sun C, Ye Y, Tan Z, Liu Y, Li Y, Hu W, Liang K, Egranov SD, Huang LA, Zhang Z, Zhang Y, Yao J, Nguyen TK, Zhao Z, Wu A, Marks JR, Caudle AS, Sahin AA, Gao J, Gammon ST, Piwnica-Worms D, Hu J, Chiao PJ, Yu D, Hung MC, Curran MA, Calin GA, Ying H, Han L, Lin C, Yang L. Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Sci Adv. 2023 02 03; 9(5):eadd6995. PMID: 36724291; PMCID: PMC9891701.
      Citations: 5     Fields:    Translation:HumansCells
    56. Zheng S, Song J, Linghu D, Yang R, Liu B, Xue Z, Chen Q, Liu C, Zhong D, Hung MC, Sun L. Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity. Int J Biol Sci. 2023; 19(3):981-993. PMID: 36778120; PMCID: PMC9909994.
      Citations: 1     Fields:    Translation:HumansAnimals
    57. Lin ZS, Chung CC, Liu YC, Chang CH, Liu HC, Liang YY, Huang TL, Chen TM, Lee CH, Tang CH, Hung MC, Chen YH. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. Elife. 2023 01 09; 12. PMID: 36622753; PMCID: PMC9829410.
      Citations: 1     Fields:    
    58. Hou J, Wang S, Miao R, Zhang X, Hung MC. Detection of Gasdermin C-Mediated Cancer Cell Pyroptosis. Methods Mol Biol. 2023; 2641:135-146. PMID: 37074647.
      Citations:    Fields:    
    59. Hsieh CY, Chang WC, Lin CC, Chen JH, Lin CY, Liu CH, Lin C, Hung MC. Combination treatment of arsenic trioxide and osimertinib in recurrent and metastatic head and neck squamous cell carcinoma. Am J Cancer Res. 2022; 12(11):5049-5061. PMID: 36504903; PMCID: PMC9729903.
      Citations:    
    60. Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Lim B, Lehmann LH, Salem JE, Johnson DB, Curran MA, Yu D, Han L, Darabi R, Yang L, Moslehi JJ, Lin C. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Sci Transl Med. 2022 11 02; 14(669):eabo1981. PMID: 36322628; PMCID: PMC9809130.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    61. Chu YY, Yam C, Yamaguchi H, Hung MC. Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors. J Biomed Sci. 2022 Oct 25; 29(1):86. PMID: 36284291; PMCID: PMC9594904.
      Citations: 1     Fields:    Translation:Humans
    62. Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC, Yamaguchi H, Jiang Z, Liu C, Li CF, Nie L, Chan LC, Gao Y, Wang SC, Liu J, Westin SN, Lee S, Sood AK, Yang L, Hortobagyi GN, Yu D, Hung MC. Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022 10; 3(10):1211-1227. PMID: 36253486; PMCID: PMC9586872.
      Citations: 1     Fields:    Translation:HumansAnimals
    63. Mei Y, Hang Q, Teng H, Yao F, Chen MK, Hung MC, Sun Y, Ma L. ZRANB1 is an NBS1 deubiquitinase and a potential target to overcome radioresistance and PARP inhibitor resistance in triple-negative breast cancer. Genes Dis. 2023 Sep; 10(5):1739-1742. PMID: 37492703; PMCID: PMC10363626.
      Citations:    
    64. Wang SH, Chou WC, Huang HC, Lee TA, Hsiao TC, Wang LH, Huang KB, Kuo CT, Chao CH, Chang SJ, Hsu JM, Weng J, Ren N, Li FA, Lai YJ, Zhou C, Hung MC, Li CW. Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis. Am J Cancer Res. 2022; 12(10):4721-4736. PMID: 36381324; PMCID: PMC9641385.
      Citations: 1     
    65. Li YC, Yamaguchi H, Liu YY, Hsu KC, Sun TH, Sun PC, Hung MC. Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1. Am J Cancer Res. 2022; 12(10):4865-4878. PMID: 36381327; PMCID: PMC9641407.
      Citations: 1     
    66. Zhou Q, Yin Y, Yu M, Gao D, Sun J, Yang Z, Weng J, Chen W, Atyah M, Shen Y, Ye Q, Li CW, Hung MC, Dong Q, Zhou C, Ren N. GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism. Redox Biol. 2022 10; 56:102458. PMID: 36116159; PMCID: PMC9483790.
      Citations:    
    67. Lau P, Zhang G, Zhao S, Liang L, Zhang H, Zhou G, Hung MC, Chen X, Liu H. Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis. Cell Mol Immunol. 2022 10; 19(10):1153-1167. PMID: 36050478; PMCID: PMC9508236.
      Citations:    
    68. Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Zeng GD, Wang F, Feng WX, Zheng J, Wang YN, Zeng B, Liu Q, Hung MC, Wan XB. DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0. Cell Death Dis. 2022 08 16; 13(8):709. PMID: 35974014; PMCID: PMC9381602.
      Citations:    
    69. Ho CT, Lin SP, Tseng LM, Hung MC, Hung SC. Snail induces dormancy in disseminated luminal type A breast cancer through Src inhibition. Am J Cancer Res. 2022; 12(8):3932-3946. PMID: 36119827; PMCID: PMC9442010.
      Citations:    
    70. Wang WJ, Chen Y, Su WC, Liu YY, Shen WJ, Chang WC, Huang ST, Lin CW, Wang YC, Yang CS, Hou MH, Chou YC, Wu YC, Wang SC, Hung MC. Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2. J Food Biochem. 2022 10; 46(10):e14354. PMID: 35894128; PMCID: PMC9353385.
      Citations:    Fields:    
    71. Chen HF, Hsueh PR, Liu YY, Chen Y, Chang SY, Wang WJ, Wu CS, Tsai YM, Liu YS, Su WC, Chou YC, Hung MC. Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2. Am J Cancer Res. 2022; 12(7):3333-3346. PMID: 35968340; PMCID: PMC9360250.
      Citations:    
    72. Wu CS, Chiang HM, Chen Y, Chen CY, Chen HF, Su WC, Wang WJ, Chou YC, Chang WC, Wang SC, Hung MC. Prospects of Coffee Leaf against SARS-CoV-2 Infection. Int J Biol Sci. 2022; 18(12):4677-4689. PMID: 35874948; PMCID: PMC9305275.
      Citations:    Fields:    Translation:AnimalsCells
    73. Wang SC, Chou IW, Hung MC. Natural tannins as anti-SARS-CoV-2 compounds. Int J Biol Sci. 2022; 18(12):4669-4676. PMID: 35874955; PMCID: PMC9305278.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    74. Yen JH, Huang WC, Lin SC, Huang YW, Chio WT, Tsay GJ, Hung MC, Huang ST. Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis. Mol Ther Oncolytics. 2022 Sep 15; 26:158-174. PMID: 35860009; PMCID: PMC9271981.
      Citations:    
    75. Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J, Hung MC, Sood AK. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2022 Jun 21; 39(12):110999. PMID: 35732127; PMCID: PMC9272813.
      Citations:    Fields:    
    76. Hsieh RC, Krishnan S, Wu RC, Boda AR, Liu A, Winkler M, Hsu WH, Lin SH, Hung MC, Chan LC, Bhanu KR, Srinivasamani A, De Azevedo RA, Chou YC, DePinho RA, Gubin M, Vilar E, Chen CH, Slay R, Jayaprakash P, Hegde SM, Hartley G, Lea ST, Prasad R, Morrow B, Couillault CA, Steiner M, Wang CC, Venkatesulu BP, Taniguchi C, Kim YSB, Chen J, Rudqvist NP, Curran MA. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol. 2022 06 10; 7(72):eabl9330. PMID: 35687697; PMCID: PMC9373855.
      Citations:    Fields:    Translation:HumansAnimalsCells
    77. Zhao X, Wei Y, Chu YY, Li Y, Hsu JM, Jiang Z, Liu C, Hsu JL, Chang WC, Yang R, Chan LC, Qu J, Zhang S, Ying H, Yu D, Hung MC. Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function. Cancer Res. 2022 06 06; 82(11):2185-2195. PMID: 35385574.
      Citations:    Fields:    Translation:HumansAnimalsCells
    78. Wu CS, Lu WH, Hung MC, Huang YS, Chao HW. From polyploidy to polyploidy reversal: its role in normal and disease states. Trends Genet. 2022 10; 38(10):991-995. PMID: 35637074.
      Citations:    Fields:    
    79. Xue Z, Zheng S, Linghu D, Liu B, Yang Y, Chen MK, Huang H, Song J, Li H, Wang J, Hung MC, Zhong D, Sun L. PD-L1 deficiency sensitizes tumor cells to DNA-PK inhibition and enhances cGAS-STING activation. Am J Cancer Res. 2022; 12(5):2363-2375. PMID: 35693073; PMCID: PMC9185610.
      Citations:    
    80. Wang YL, Zhao WW, Bai SM, Feng LL, Bie SY, Gong L, Wang F, Wei MB, Feng WX, Pang XL, Qin CL, Yin XK, Wang YN, Zhou W, Wahl DR, Liu Q, Chen M, Hung MC, Wan XB. MRNIP condensates promote DNA double-strand break sensing and end resection. Nat Commun. 2022 05 12; 13(1):2638. PMID: 35551189; PMCID: PMC9098523.
      Citations:    Fields:    Translation:HumansCells
    81. Yamaguchi H, Wang SC, Hung MC. Prospects of the potential strategies to improve the efficacy of anti-PD-1/PD-L1 therapy. Clin Transl Med. 2022 05; 12(5):e803. PMID: 35588146; PMCID: PMC9119611.
      Citations: 1     Fields:    Translation:Humans
    82. Liu C, Zha Z, Zhou C, Chen Y, Xia W, Wang YN, Lee HH, Yin Y, Yan M, Chang CW, Chan LC, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N, Hung MC. Erratum to 'Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma' [J Hepatol 2021 (907-918)]. J Hepatol. 2022 Aug; 77(2):580. PMID: 35489965.
      Citations:    Fields:    
    83. Jabbarzadeh Kaboli P, Shabani S, Sharma S, Partovi Nasr M, Yamaguchi H, Hung MC. Shedding light on triple-negative breast cancer with Trop2-targeted antibody-drug conjugates. Am J Cancer Res. 2022; 12(4):1671-1685. PMID: 35530278; PMCID: PMC9077081.
      Citations:    
    84. Chang LC, Chiang SK, Chen SE, Hung MC. Targeting 2-oxoglutarate dehydrogenase for cancer treatment. Am J Cancer Res. 2022; 12(4):1436-1455. PMID: 35530286; PMCID: PMC9077069.
      Citations:    
    85. Tu J, Huo Z, Yu Y, Zhu D, Xu A, Huang MF, Hu R, Wang R, Gingold JA, Chen YH, Tsai KL, Forcioli-Conti NR, Huang SXL, Webb TR, Su J, Bazer DA, Jia P, Yustein JT, Wang LL, Hung MC, Zhao Z, Huff CD, Shen J, Zhao R, Lee DF. Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies. Proc Natl Acad Sci U S A. 2022 04 19; 119(16):e2117857119. PMID: 35412907; PMCID: PMC9169787.
      Citations:    Fields:    Translation:HumansCells
    86. Yang R, Sun L, Li CF, Wang YH, Xia W, Liu B, Chu YY, Bover L, Vien L, Hung MC. Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death. J Biol Chem. 2022 04; 298(4):101821. PMID: 35283189; PMCID: PMC9006662.
      Citations:    Fields:    Translation:HumansCells
    87. Cha JH, Chan LC, Wang YN, Chu YY, Wang CH, Lee HH, Xia W, Shyu WC, Liu SP, Yao J, Chang CW, Cheng FR, Liu J, Lim SO, Hsu JL, Yang WH, Hortobagyi GN, Lin C, Yang L, Yu D, Jeng LB, Hung MC. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. J Biol Chem. 2022 04; 298(4):101817. PMID: 35278434; PMCID: PMC8988001.
      Citations:    Fields:    Translation:HumansAnimalsCells
    88. Wang YN, Lee HH, Wei Y, Chu YY, Xia W, Wang M, Yu D, Hung MC. An optimized protocol for PD-L1 pathological assessment with patient sample deglycosylation to improve correlation with therapeutic response. STAR Protoc. 2022 03 18; 3(1):101198. PMID: 35243381; PMCID: PMC8885744.
      Citations:    Fields:    Translation:Humans
    89. Zhou C, Weng J, Gao Y, Liu C, Zhu X, Zhou Q, Li CW, Sun J, Atyah M, Yi Y, Ye Q, Shi Y, Dong Q, Liu Y, Hung MC, Ren N. A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma. J Clin Transl Hepatol. 2022 Oct 28; 10(5):925-938. PMID: 36304510; PMCID: PMC9547263.
      Citations:    
    90. Yu M, Chen Z, Zhou Q, Zhang B, Huang J, Jin L, Zhou B, Liu S, Yan J, Li X, Zhang W, Liu C, Hu B, Fu P, Zhou C, Xu Y, Xiao Y, Zhou J, Fan J, Ren N, Hung MC, Guo L, Li H, Ye Q. PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy. J Hepatol. 2022 07; 77(1):140-151. PMID: 35157958.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    91. Yamaguchi H, Hsu JM, Yang WH, Hung MC. Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics. Nat Rev Clin Oncol. 2022 05; 19(5):287-305. PMID: 35132224.
      Citations: 2     Fields:    Translation:HumansCells
    92. Chen Y, Yang WH, Chen HF, Huang LM, Gao JY, Lin CW, Wang YC, Yang CS, Liu YL, Hou MH, Tsai CL, Chou YZ, Huang BY, Hung CF, Hung YL, Wang WJ, Su WC, Kumar V, Wu YC, Chao SW, Chang CS, Chen JS, Chiang YP, Cho DY, Jeng LB, Tsai CH, Hung MC. Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2. J Biol Chem. 2022 03; 298(3):101658. PMID: 35101449; PMCID: PMC8800562.
      Citations: 1     Fields:    Translation:HumansCellsPHPublic Health
    93. Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J, Hung MC, Sood AK. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2022 01 25; 38(4):110301. PMID: 35081345; PMCID: PMC8860355.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    94. Ou-Yang F, Li CL, Chen CC, Shen YC, Moi SH, Luo CW, Xia WY, Wang YN, Lee HH, Wang LH, Wang SC, Pan MR, Hou MF, Hung MC. De-glycosylated membrane PD-L1 in tumor tissues as a biomarker for responsiveness to atezolizumab (Tecentriq) in advanced breast cancer patients. Am J Cancer Res. 2022; 12(1):123-137. PMID: 35141008; PMCID: PMC8822291.
      Citations: 3     
    95. Shih DJH, Chen MK, Yin J, McGrail DJ, Dai H, Wei R, Zhang J, Zheng WJ, Do KA, Yang L, Hung MC, Lin SY. Exploiting induced vulnerability to overcome PARPi resistance and clonal heterogeneity in BRCA mutant triple-negative inflammatory breast cancer. Am J Cancer Res. 2022; 12(1):337-354. PMID: 35141022; PMCID: PMC8822293.
      Citations:    
    96. Chu CS, Yang CY, Yeh CC, Lin RT, Chen CC, Bai LY, Hung MC, Lin CC, Wu CY, Lin JT. Endoscopic ultrasound-guided fine-needle biopsy as a tool for studying the intra-tumoral microbiome in pancreatic ductal adenocarcinoma: a pilot study. Sci Rep. 2022 01 07; 12(1):107. PMID: 34997106; PMCID: PMC8741880.
      Citations:    Fields:    Translation:HumansCells
    97. Feng L, Liu Z, Li C, Li Z, Lou X, Shao L, Wang Y, Huang Y, Chen H, Pang X, Liu S, He F, Zheng J, Meng X, Xie P, Yang G, Ding Y, Wei M, Yun J, Hung MC, Zhou W, Wahl DR, Lan P, Tian J, Wan X. Development and validation of a radiopathomics model to predict pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a multicentre observational study. Lancet Digit Health. 2022 01; 4(1):e8-e17. PMID: 34952679.
      Citations: 3     Fields:    Translation:Humans
    98. Sun LL, Linghu DL, Hung MC. Ferroptosis: a promising target for cancer immunotherapy. Am J Cancer Res. 2021; 11(12):5856-5863. PMID: 35018229; PMCID: PMC8727800.
      Citations: 4     
    99. Deng Y, Xia X, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung MC, Ma L. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nat Commun. 2021 12 06; 12(1):7041. PMID: 34873175; PMCID: PMC8649069.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    100. Hou J, Hsu JM, Hung MC. Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity. Mol Cell. 2021 11 18; 81(22):4579-4590. PMID: 34562371; PMCID: PMC8604761.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    101. Chen GY, Pan YC, Wu TY, Yao TY, Wang WJ, Shen WJ, Ahmed A, Chan ST, Tang CH, Huang WC, Hung MC, Yang JC, Wu YC. Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay. J Tradit Complement Med. 2022 Jan; 12(1):73-89. PMID: 34549024; PMCID: PMC8443859.
      Citations: 1     
    102. Lin YZ, Lee CC, Cho DY, Wang YL, Chen CY, Weng CY, Chiu SC, Hung MC, Wang SC. Suppression of breast cancer cells resistant to a pure anti-estrogen with CAR-transduced natural killer cells. Am J Cancer Res. 2021; 11(9):4455-4469. PMID: 34659898; PMCID: PMC8493389.
      Citations: 1     
    103. Li Y, Zhang Y, Hu Q, Egranov SD, Xing Z, Zhang Z, Liang K, Ye Y, Pan Y, Chatterjee SS, Mistretta B, Nguyen TK, Hawke DH, Gunaratne PH, Hung MC, Han L, Yang L, Lin C. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med. 2021 08 28; 13(1):137. PMID: 34454586; PMCID: PMC8403366.
      Citations:    Fields:    Translation:HumansAnimalsCells
    104. Wang YL, Lee CC, Shen YC, Lin PL, Wu WR, Lin YZ, Cheng WC, Chang H, Hung Y, Cho YC, Liu LC, Xia WY, Ji JH, Liang JA, Chiang SF, Liu CG, Yao J, Hung MC, Wang SC. Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Rep. 2021 08 24; 36(8):109537. PMID: 34433039.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    105. Liu J, Yuan B, Cao J, Luo H, Gu S, Zhang M, Ding R, Zhang L, Zhou F, Hung MC, Xu P, Lin X, Jin J, Feng XH. AMBRA1 Promotes TGF? Signaling via Nonproteolytic Polyubiquitylation of Smad4. Cancer Res. 2021 10 01; 81(19):5007-5020. PMID: 34362797.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    106. Li Y, Tan Z, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C, Liao L, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD, Putluri N, Coarfa C, Hawke DH, Gunaratne PH, Tsai KL, Han L, Hung MC, Calin GA, Namour F, Muntau AC, Blau N, Sutton VR, Zhang S, Lin C, Yang L, Gu?ant JL, Schiff M, Feillet F. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021 08 06; 373(6555):662-673. PMID: 34353949; PMCID: PMC9714245.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    107. Lin YZ, Shen YC, Wu WR, Wang WJ, Wang YL, Lin CY, Hung MC, Wang SC. Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral Particles. Int J Mol Sci. 2021 Jun 28; 22(13). PMID: 34203261; PMCID: PMC8268654.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    108. Qiu Y, Yang Y, Yang R, Liu C, Hsu JM, Jiang Z, Sun L, Wei Y, Li CW, Yu D, Zhang J, Hung MC. Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer. Oncogene. 2021 08; 40(31):4992-5001. PMID: 34172932; PMCID: PMC8342306.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    109. Chen CH, Wang BW, Hsiao YC, Wu CY, Cheng FJ, Hsia TC, Chen CY, Wang Y, Weihua Z, Chou RH, Tang CH, Chen YJ, Wei YL, Hsu JL, Tu CY, Hung MC, Huang WC. PKCd-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs. Oncogene. 2021 Jul; 40(29):4796-4808. PMID: 34155348; PMCID: PMC8298203.
      Citations: 2     Fields:    Translation:Cells
    110. Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Liu D, Bai X, Sun B, Hung MC, Liu L, Wands JR, Dong X. Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture. Am J Cancer Res. 2021; 11(6):2537-2567. PMID: 34249415; PMCID: PMC8263653.
      Citations: 1     
    111. Fan XJ, Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Feng WX, Wang YN, Liu Q, Hung MC, Wan XB. NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation. Am J Cancer Res. 2021; 11(6):2838-2852. PMID: 34249431; PMCID: PMC8263645.
      Citations:    
    112. Lin YX, Hung MC, Hsu JL, Hsu JM. The N-linked glycosylations of TIGIT Asn32 and Asn101 facilitate PVR/TIGIT interaction. Biochem Biophys Res Commun. 2021 07 12; 562:9-14. PMID: 34030043.
      Citations:    Fields:    Translation:HumansCells
    113. Wang YL, Wei MB, Zhao WW, Feng LL, Yin XK, Bai SM, Wan XB, Hung MC, Zou AZ, Wang MH, Zheng J, Qin C, Fan XJ. Glycosylation of Siglec15 promotes immunoescape and tumor growth. Am J Cancer Res. 2021; 11(5):2291-2302. PMID: 34094685; PMCID: PMC8167674.
      Citations:    
    114. Lee HH, Wang YN, Yang WH, Xia W, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S, Yao J, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J, Ye Y, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL, Yamaguchi H, Pang D, Hortobagyi GN, Yu D, Hung MC. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021 05 13; 12(1):2788. PMID: 33986289; PMCID: PMC8119676.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    115. Huang ST, Chen Y, Chang WC, Chen HF, Lai HC, Lin YC, Wang WJ, Wang YC, Yang CS, Wang SC, Hung MC. Scutellaria barbata D. Don Inhibits the Main Proteases (Mpro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Viruses. 2021 05 02; 13(5). PMID: 34063247; PMCID: PMC8147405.
      Citations: 5     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    116. Dai X, Bu X, Gao Y, Guo J, Hu J, Jiang C, Zhang Z, Xu K, Duan J, He S, Zhang J, Wan L, Liu T, Zhou X, Hung MC, Freeman GJ, Wei W. Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Mol Cell. 2021 06 03; 81(11):2317-2331.e6. PMID: 33909988; PMCID: PMC8178223.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    117. Jiang Z, Lim SO, Yan M, Hsu JL, Yao J, Wei Y, Chang SS, Yamaguchi H, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C, Yu D, Hung MC. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest. 2021 04 15; 131(8). PMID: 33855973; PMCID: PMC8262501.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    118. Chen Y, Huang WC, Yang CS, Cheng FJ, Chiu YF, Chen HF, Huynh TK, Huang CF, Chen CH, Wang HC, Hung MC. Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. Am J Cancer Res. 2021; 11(3):827-836. PMID: 33791156; PMCID: PMC7994159.
      Citations: 2     
    119. Yang R, Sun L, Li CF, Wang YH, Yao J, Li H, Yan M, Chang WC, Hsu JM, Cha JH, Hsu JL, Chou CW, Sun X, Deng Y, Chou CK, Yu D, Hung MC. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Nat Commun. 2021 02 05; 12(1):832. PMID: 33547304; PMCID: PMC7864927.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    120. Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, Feng LL, Wei MB, Qin CL, Wang F, Chen ZL, Yi HJ, Huang Y, Xie PY, Kim T, Wang YN, Hou JW, Li CW, Liu Q, Fan XJ, Hung MC, Wan XB. PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Oncogene. 2021 02; 40(7):1375-1389. PMID: 33420374; PMCID: PMC7892343.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    121. Cho J, Min HY, Lee HJ, Hyun SY, Sim JY, Noh M, Hwang SJ, Park SH, Boo HJ, Lee HJ, Hong S, Park RW, Shin YK, Hung MC, Lee HY. RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. J Clin Invest. 2021 01 04; 131(1). PMID: 33393490; PMCID: PMC7773398.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    122. Gao Y, Chen MK, Chu YY, Yang L, Yu D, Liu Y, Hung MC. Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells. Am J Cancer Res. 2021; 11(1):236-250. PMID: 33520371; PMCID: PMC7840709.
      Citations: 3     
    123. Cheng FJ, Chen CH, Tsai WC, Wang BW, Yu MC, Hsia TC, Wei YL, Hsiao YC, Hu DW, Ho CY, Li TS, Wu CY, Chou WY, Yu YL, Tang CH, Chen CY, Chen CM, Hsu JL, Chen HF, Chen Y, Tu CY, Hung MC, Huang WC. Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC. Oncogene. 2021 02; 40(6):1162-1175. PMID: 33335306; PMCID: PMC7878190.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    124. Wang SC, Chen Y, Wang YC, Wang WJ, Yang CS, Tsai CL, Hou MH, Chen HF, Shen YC, Hung MC. Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease. Am J Cancer Res. 2020; 10(12):4538-4546. PMID: 33415017; PMCID: PMC7783773.
      Citations: 21     
    125. Li H, Kuang X, Liang L, Ye Y, Zhang Y, Li J, Ma F, Tao J, Lei G, Zhao S, Su J, Yang N, Peng C, Xu X, Hung MC, Han L, Liu H, Liu J, Chen X. The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1. Adv Sci (Weinh). 2021 Jan; 8(2):2001596. PMID: 33510997; PMCID: PMC7816704.
      Citations: 14     Fields:    
    126. Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB, Hung MC, He C. Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation. Mol Cell. 2020 11 19; 80(4):633-647.e7. PMID: 33217317; PMCID: PMC7720844.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    127. Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol. 2020 Nov; 22(11):1396. PMID: 33033376.
      Citations: 4     Fields:    
    128. Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P, Cheng J, Farida A, Hung MC, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 2020 11; 22(11):1332-1345. PMID: 33106653; PMCID: PMC7951180.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    129. Liu C, Zha Z, Zhou C, Chen Y, Xia W, Wang YN, Lee HH, Yin Y, Yan M, Chang CW, Chan LC, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N, Hung MC. Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma. J Hepatol. 2021 04; 74(4):907-918. PMID: 33031845; PMCID: PMC7979498.
      Citations: 5     Fields:    Translation:HumansAnimals
    130. Ai D, Yao J, Yang F, Huo L, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S, Bell D, Liu J, Wang H, Tan D, Torres-Cabala C, Gan Q, Wu Y, Albarracin C, Hung MC, Meric-Bernstam F, Wistuba II, Prieto VG, Sahin AA, Ding Q. TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer. Mod Pathol. 2021 04; 34(4):710-719. PMID: 33011748.
      Citations: 4     Fields:    Translation:Humans
    131. Chou CW, Yang RY, Chan LC, Li CF, Sun L, Lee HH, Lee PC, Sher YP, Ying H, Hung MC. Erratum: The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Am J Cancer Res. 2020; 10(10):3507. PMID: 33163286; PMCID: PMC7642660.
      Citations:    
    132. Song X, Zhou Z, Li H, Xue Y, Lu X, Bahar I, Hung MC, Wan Y, Kepp O, Kroemer G. Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers. Cancer Discov. 2020 12; 10(12):1872-1893. PMID: 32938586; PMCID: PMC7710601.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    133. Hou J, Zhao R, Xia W, Chang CW, You Y, Hsu JM, Nie L, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B, Tainer JA, Hung MC. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol. 2020 10; 22(10):1264-1275. PMID: 32929201; PMCID: PMC7653546.
      Citations: 134     Fields:    Translation:HumansAnimalsCells
    134. Zhou C, Weng J, Liu C, Zhou Q, Chen W, Hsu JL, Sun J, Atyah M, Xu Y, Shi Y, Shen Y, Dong Q, Hung MC, Ren N. High RPS3A expression correlates with low tumor immune cell infiltration and unfavorable prognosis in hepatocellular carcinoma patients. Am J Cancer Res. 2020; 10(9):2768-2784. PMID: 33042616; PMCID: PMC7539769.
      Citations: 6     
    135. Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, Lai LC, Shih JY, Liu YH, Chao KSC, Hsu JL, Lee PC, Sun X, Hung MC, Sher YP. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics. 2020; 10(24):10925-10939. PMID: 33042262; PMCID: PMC7532684.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    136. Cha JH, Chan LC, Song MS, Hung MC. New Approaches on Cancer Immunotherapy. Cold Spring Harb Perspect Med. 2020 08 03; 10(8). PMID: 31615865; PMCID: PMC7156317.
      Citations: 1     Fields:    
    137. Wang YC, Yang WH, Yang CS, Hou MH, Tsai CL, Chou YZ, Hung MC, Chen Y. Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug. Am J Cancer Res. 2020; 10(8):2535-2545. PMID: 32905393; PMCID: PMC7471349.
      Citations: 23     
    138. Chou CW, Yang RY, Chan LC, Li CF, Sun L, Lee HH, Lee PC, Sher YP, Ying H, Hung MC. The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Am J Cancer Res. 2020; 10(8):2621-2634. PMID: 32905506; PMCID: PMC7471351.
      Citations: 9     
    139. Jiang Z, Hsu JL, Li Y, Hortobagyi GN, Hung MC. Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment. Front Oncol. 2020; 10:1197. PMID: 32775303; PMCID: PMC7387712.
      Citations: 9     
    140. Wang YN, Lee HH, Hsu JL, Yu D, Hung MC. The impact of PD-L1?N-linked glycosylation on cancer therapy and clinical diagnosis. J Biomed Sci. 2020 Jul 03; 27(1):77. PMID: 32620165; PMCID: PMC7333976.
      Citations: 30     Fields:    Translation:HumansCells
    141. Huang ST, Lai HC, Lin YC, Huang WT, Hung HH, Ou SC, Lin HJ, Hung MC. Principles and treatment strategies for the use of Chinese herbal medicine in patients at different stages of coronavirus infection. Am J Cancer Res. 2020; 10(7):2010-2031. PMID: 32774998; PMCID: PMC7407358.
      Citations: 9     
    142. Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, Lin HK. Author Correction: A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1a activation, tumorigenesis and metastasis. Nat Cell Biol. 2020 Jul; 22(7):907. PMID: 32504031.
      Citations:    Fields:    
    143. Chen MK, Hsu JL, Hung MC. Nuclear receptor tyrosine kinase transport and functions in cancer. Adv Cancer Res. 2020; 147:59-107. PMID: 32593407.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    144. Zhang L, Yao J, Wei Y, Zhou Z, Li P, Qu J, Badu-Nkansah A, Yuan X, Huang YW, Fukumura K, Mao X, Chang WC, Saunus J, Lakhani S, Huse JT, Hung MC, Yu D. Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases. Sci Transl Med. 2020 05 27; 12(545). PMID: 32461334; PMCID: PMC7948522.
      Citations: 21     Fields:    Translation:AnimalsCells
    145. Zhou B, Yan J, Guo L, Zhang B, Liu S, Yu M, Chen Z, Zhang K, Zhang W, Li X, Xu Y, Xiao Y, Zhou J, Fan J, Hung MC, Li H, Ye Q. Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma. Theranostics. 2020; 10(14):6530-6543. PMID: 32483468; PMCID: PMC7255037.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    146. Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T, Hung MC, Lu Z. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020 04; 580(7804):530-535. PMID: 32322062.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    147. Han Y, Wei Y, Yao J, Chu YY, Li CW, Hsu JL, Nie L, Hung MC. Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERa expression in high-grade serous ovarian carcinoma. Am J Cancer Res. 2020; 10(4):1194-1206. PMID: 32368395; PMCID: PMC7191104.
      Citations: 5     
    148. Zhou C, Liu C, Liu W, Chen W, Yin Y, Li CW, Hsu JL, Sun J, Zhou Q, Li H, Hu B, Fu P, Atyah M, Ma Q, Xu Y, Dong Q, Hung MC, Ren N. SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway. Theranostics. 2020; 10(10):4627-4643. PMID: 32292519; PMCID: PMC7150495.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    149. Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, Fang F, Xie Y, Tao J, Zhang J, Chen M, Peng C, Sun L, Zhang X, Liu J, Han L, Xu X, Hung MC, Chen X. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell. 2020 03 16; 37(3):324-339.e8. PMID: 32183950.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    150. Sun L, Li CW, Chung EM, Yang R, Kim YS, Park AH, Lai YJ, Yang Y, Wang YH, Liu J, Qiu Y, Khoo KH, Yao J, Hsu JL, Cha JH, Chan LC, Hsu JM, Lee HH, Yoo SS, Hung MC. Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity. Cancer Res. 2020 06 01; 80(11):2298-2310. PMID: 32156778; PMCID: PMC7272274.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    151. Chou CK, Liu YL, Chen YI, Huang PJ, Tsou PH, Chen CT, Lee HH, Wang YN, Hsu JL, Lee JF, Yankeelov TE, Kameoka J, Yeh HC, Hung MC. Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies. ACS Sens. 2020 02 28; 5(2):296-302. PMID: 32073836; PMCID: PMC7093205.
      Citations:    Fields:    Translation:HumansAnimals
    152. Sun X, Li CW, Wang WJ, Chen MK, Li H, Lai YJ, Hsu JL, Koller PB, Chan LC, Lee PC, Cheng FJ, Yam C, Chen GY, Hung MC. Inhibition of c-MET upregulates PD-L1 expression in lung adenocarcinoma. Am J Cancer Res. 2020; 10(2):564-571. PMID: 32195027; PMCID: PMC7061748.
      Citations: 5     
    153. Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK, Yamaguchi H, Lee PC, Han Y, Nie L, Sun X, Moulder SL, Hess KR, Wang B, Hsu JL, Hortobagyi GN, Litton J, Chang JT, Hung MC. Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. Am J Cancer Res. 2020; 10(2):648-661. PMID: 32195033; PMCID: PMC7061756.
      Citations: 17     
    154. Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC. Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun. 2020 Jan 29; 11(1):673. PMID: 31996688; PMCID: PMC6989459.
      Citations: 1     Fields:    
    155. Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J, Hung MC, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH. Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. Theranostics. 2020; 10(1):201-217. PMID: 31903115; PMCID: PMC6929620.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    156. Yen YT, Chien M, Lai YC, Chen DP, Chuong CM, Hung MC, Hung SC. PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo. Cells. 2019 Dec 30; 9(1). PMID: 31905853; PMCID: PMC7017129.
      Citations: 3     Fields:    Translation:AnimalsCells
    157. Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK, Hung MC, Nagel ZD, Ellenberger T, Kim IK, Jones DE, Ahmed Z, Tainer JA. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 12 11; 10(1):5654. PMID: 31827085; PMCID: PMC6906431.
      Citations: 39     Fields:    Translation:HumansCells
    158. Saab S, Chang OS, Nagaoka K, Hung MC, Yamaguchi H. The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. Am J Cancer Res. 2019; 9(12):2719-2729. PMID: 31911857; PMCID: PMC6943358.
      Citations: 5     
    159. McCleary-Wheeler AL, Carr RM, Palmer SR, Smyrk TC, Allred JB, Almada LL, Tolosa EJ, Lamberti MJ, Marks DL, Borad MJ, Molina JR, Qi Y, Lingle WL, Grothey A, Pitot HC, Jatoi A, Northfelt DW, Bryce AH, McWilliams RR, Okuno SH, Haluska P, Kim GP, Colon-Otero G, Lowe VJ, Callstrom MR, Ma WW, Bekaii-Saab T, Hung MC, Erlichman C, Fernandez-Zapico ME. Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer. Pancreatology. 2020 Jan; 20(1):101-109. PMID: 31787526; PMCID: PMC7195700.
      Citations: 6     Fields:    Translation:HumansCTClinical Trials
    160. Nie L, Wei Y, Zhang F, Hsu YH, Chan LC, Xia W, Ke B, Zhu C, Deng R, Tang J, Yao J, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC, Yamaguchi H, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN, Hung MC. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun. 2019 11 08; 10(1):5114. PMID: 31704972; PMCID: PMC6841924.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    161. Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Bai X, Sun B, Hung MC, Liu L, Wands J, Dong X. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019 11 07; 18(1):156. PMID: 31694640; PMCID: PMC6836474.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    162. Cha JH, Chan LC, Li CW, Hsu JL, Hung MC. Mechanisms Controlling PD-L1 Expression in Cancer. Mol Cell. 2019 11 07; 76(3):359-370. PMID: 31668929; PMCID: PMC6981282.
      Citations: 138     Fields:    Translation:HumansAnimalsCells
    163. Wu X, Park M, Sarbassova DA, Ying H, Lee MG, Bhattacharya R, Ellis L, Peterson CB, Hung MC, Lin HK, Bersimbaev RI, Song MS, Sarbassov DD. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 05 15; 146(10):2822-2828. PMID: 31472018; PMCID: PMC7365556.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    164. Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y, Hung MC, Chen J, Lin SH. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019 09 25; 10(1):4363. PMID: 31554794; PMCID: PMC6761205.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    165. Pataer A, Ozpolat B, Shao R, Cashman NR, Plotkin SS, Samuel CE, Lin SH, Kabil NN, Wang J, Majidi M, Fang B, Roth JA, Vaporciyan AA, Wistuba II, Hung MC, Swisher SG. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. 2020 01; 39(4):801-813. PMID: 31554935; PMCID: PMC6976521.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    166. Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY, Hung MC, Chen RH. BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. J Cell Biol. 2019 09 02; 218(9):3002-3018. PMID: 31387940; PMCID: PMC6719446.
      Citations: 4     Fields:    Translation:HumansCells
    167. Lee HH, Wang YN, Xia W, Chen CH, Rau KM, Ye L, Wei Y, Chou CK, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC, Wistuba II, Hsu JL, Hortobagyi GN, Hung MC. Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy. Cancer Cell. 2019 08 12; 36(2):168-178.e4. PMID: 31327656; PMCID: PMC6793936.
      Citations: 92     Fields:    Translation:HumansCells
    168. Chan LC, Li CW, Xia W, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z, Lim SO, Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y, Nie L, Hsu JL, Li H, Ye Q, Hassan MM, Amin HM, Kaseb AO, Lin X, Wang SC, Hung MC. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest. 2019 07 15; 129(8):3324-3338. PMID: 31305264; PMCID: PMC6668668.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    169. Wang P, Gong Y, Guo T, Li M, Fang L, Yin S, Kamran M, Liu Y, Xu J, Xu L, Peng F, Xue X, Yang M, Hung MC, Lam EW, Gu C, Wang C, Zhan Q, Liu Q. Activation of Aurora A kinase increases YAP stability via blockage of autophagy. Cell Death Dis. 2019 06 03; 10(6):432. PMID: 31160567; PMCID: PMC6547697.
      Citations: 17     Fields:    Translation:HumansCells
    170. Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y, Xia W, Gong J, Pan Y, Chatterjee SS, Yao J, Evans KW, Nguyen TK, Park PK, Liu J, Coarfa C, Donepudi SR, Putluri V, Putluri N, Sreekumar A, Ambati CR, Hawke DH, Marks JR, Gunaratne PH, Caudle AS, Sahin AA, Hortobagyi GN, Meric-Bernstam F, Chen L, Yu D, Hung MC, Curran MA, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 2019 07; 20(7):835-851. PMID: 31160797; PMCID: PMC6619502.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    171. Ju HQ, Lu YX, Chen DL, Zuo ZX, Liu ZX, Wu QN, Mo HY, Wang ZX, Wang DS, Pu HY, Zeng ZL, Li B, Xie D, Huang P, Hung MC, Chiao PJ, Xu RH. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. J Natl Cancer Inst. 2019 Jun 01; 111(6):584-596. PMID: 30534944; PMCID: PMC6579745.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    172. Chen MK, Du Y, Sun L, Hsu JL, Wang YH, Gao Y, Huang J, Hung MC. H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. J Biol Chem. 2019 05 24; 294(21):8516-8528. PMID: 30962283; PMCID: PMC6544865.
      Citations: 4     Fields:    Translation:HumansCells
    173. Lee HH, Wang YN, Hung MC. Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology. Mol Aspects Med. 2019 12; 70:106-116. PMID: 30902663; PMCID: PMC6788960.
      Citations: 9     Fields:    Translation:HumansCells
    174. Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, Li CW, Lim SO, Sheng YY, Zhang Y, Li JH, Luo Q, Zheng Y, Zhao Y, Lu L, Jia HL, Hung MC, Dong QZ, Qin LX. Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut. 2019 09; 68(9):1653-1666. PMID: 30902885.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    175. Lu S, Han Z, Hung MC, Xu J, Xu Y, Zheng P, Zheng ZM, Zou L, Li Z, Zheng L, Kang Y, Yang Y, He L, Liao XC, Yu H, Yue Z, Liu SL, Zheng H. Racial profiling harms science. Science. 2019 Mar 22; 363(6433):1290-1292. PMID: 30898924.
      Citations:    Fields:    
    176. Liu YL, Chou CK, Kim M, Vasisht R, Kuo YA, Ang P, Liu C, Perillo EP, Chen YA, Blocher K, Horng H, Chen YI, Nguyen DT, Yankeelov TE, Hung MC, Dunn AK, Yeh HC. Assessing metastatic potential of breast cancer cells based on EGFR dynamics. Sci Rep. 2019 03 04; 9(1):3395. PMID: 30833579; PMCID: PMC6399327.
      Citations: 19     Fields:    Translation:HumansCells
    177. Wang D, Luo H, Huo Z, Chen M, Han Z, Hung M, Su B, Li Y, Wang X, Guo X, Xiao H, Lee D, Zhao R, Yang H. Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma. Am J Cancer Res. 2019; 9(3):479-495. PMID: 30949405; PMCID: PMC6448059.
      Citations: 5     
    178. Han Y, Chen MK, Wang HL, Hsu JL, Li CW, Chu YY, Liu CX, Nie L, Chan LC, Yam C, Wang SC, He GJ, Hortobagyi GN, Tan XD, Hung MC. Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. Am J Cancer Res. 2019; 9(3):608-618. PMID: 30949414; PMCID: PMC6448061.
      Citations: 14     
    179. Wang EM, Akasaka H, Zhao J, Varadhachary GR, Lee JE, Maitra A, Fleming JB, Hung MC, Wang H, Katz MHG. Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2a in Pancreatic Ductal Adenocarcinoma. Pancreas. 2019 Mar; 48(3):323-328. PMID: 30747823; PMCID: PMC6521859.
      Citations: 3     Fields:    Translation:HumansCells
    180. Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR, Putluri N, Hawke DH, Han L, Hung MC, Danesh FR, Yang L, Lin C. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019 03 01; 129(3):1129-1151. PMID: 30741721; PMCID: PMC6391108.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    181. Park MK, Yao Y, Xia W, Setijono SR, Kim JH, Vila IK, Chiu HH, Wu Y, Lee MG, Kalb RG, Hung MC, Pandolfi PP, Song SJ, Song MS, Billalabeitia EG. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nat Commun. 2019 02 07; 10(1):636. PMID: 30733438; PMCID: PMC6367354.
      Citations: 20     Fields:    Translation:AnimalsCells
    182. Li H, Li CW, Li X, Ding Q, Guo L, Liu S, Liu C, Lai CC, Hsu JM, Dong Q, Xia W, Hsu JL, Yamaguchi H, Du Y, Lai YJ, Sun X, Koller PB, Ye Q, Hung MC. MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. Gastroenterology. 2019 05; 156(6):1849-1861.e13. PMID: 30711629; PMCID: PMC6904924.
      Citations: 58     Fields:    Translation:AnimalsCells
    183. Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K, Yao J, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L, Hung MC, Zhang B, Lin C, Yang L. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Res. 2019 04; 29(4):286-304. PMID: 30631154; PMCID: PMC6461864.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    184. Wang WJ, Hsu JM, Wang YN, Lee HH, Yamaguchi H, Liao HW, Hung MC. An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5. Am J Cancer Res. 2019; 9(1):180-185. PMID: 30755821; PMCID: PMC6356926.
      Citations: 3     
    185. Dong Q, Du Y, Li H, Liu C, Wei Y, Chen MK, Zhao X, Chu YY, Qiu Y, Qin L, Yamaguchi H, Hung MC. EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma. Cancer Res. 2019 02 15; 79(4):819-829. PMID: 30573522; PMCID: PMC6886123.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    186. Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia W, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Zhang R, Wang L, Fang B, Chen T, Wong KK, Hsu JL, Hung MC. Targeting PKCd as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer Cell. 2018 12 10; 34(6):954-969.e4. PMID: 30537515; PMCID: PMC6886126.
      Citations: 26     Fields:    Translation:HumansCells
    187. Yang Y, Hsu JM, Sun L, Chan LC, Li CW, Hsu JL, Wei Y, Xia W, Hou J, Qiu Y, Hung MC. Palmitoylation stabilizes PD-L1 to promote breast tumor growth. Cell Res. 2019 01; 29(1):83-86. PMID: 30514902; PMCID: PMC6318320.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    188. Wang YN, Lee HH, Hung MC. A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases. J Biomed Sci. 2018 Nov 19; 25(1):83. PMID: 30449278; PMCID: PMC6241042.
      Citations: 6     Fields:    Translation:HumansCells
    189. Hsu JM, Li CW, Lai YJ, Hung MC. Posttranslational Modifications of PD-L1 and Their Applications in Cancer Therapy. Cancer Res. 2018 11 15; 78(22):6349-6353. PMID: 30442814; PMCID: PMC6242346.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    190. Tang Y, Joo D, Liu G, Tu H, You J, Jin J, Zhao X, Hung MC, Lin X. Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis. J Biol Chem. 2018 12 28; 293(52):20062-20072. PMID: 30361438; PMCID: PMC6311529.
      Citations: 13     Fields:    Translation:HumansCells
    191. Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H, Chiao P, Ling J, Curran MA, Maitra A, Hung MC, Lee JE, Logsdon CD, Hwang RF. Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Sci Transl Med. 2018 10 24; 10(464). PMID: 30355799; PMCID: PMC6752716.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    192. Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z, Gan B, Nakagawa S, Ellis MJ, Liang H, Hung MC, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018 12; 50(12):1705-1715. PMID: 30349115; PMCID: PMC6265076.
      Citations: 249     Fields:    Translation:HumansAnimalsCells
    193. Jewell BE, Liu M, Lu L, Zhou R, Tu J, Zhu D, Huo Z, Xu A, Wang D, Mata H, Jin W, Xia W, Rao PH, Zhao R, Hung MC, Wang LL, Lee DF. Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation. Stem Cell Res. 2018 12; 33:36-40. PMID: 30312871; PMCID: PMC6317900.
      Citations: 1     Fields:    Translation:HumansCells
    194. Yam C, Hung MC, Hortobagyi GN. CDK4/6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer: Are we at the finish line? Oncotarget. 2018 Sep 28; 9(76):34193-34195. PMID: 30344934; PMCID: PMC6188130.
      Citations: 1     Fields:    
    195. Wang T, Fan C, Yao A, Xu X, Zheng G, You Y, Jiang C, Zhao X, Hou Y, Hung MC, Lin X. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. 2018 09 18; 49(3):504-514.e4. PMID: 30231984; PMCID: PMC6880241.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    196. Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD, Hung MC, Chen J, Huang P, Li W, Gan B. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018 10; 20(10):1181-1192. PMID: 30202049; PMCID: PMC6170713.
      Citations: 208     Fields:    Translation:HumansAnimalsCells
    197. Shao B, Li CW, Lim SO, Sun L, Lai YJ, Hou J, Liu C, Chang CW, Qiu Y, Hsu JM, Chan LC, Zha Z, Li H, Hung MC. Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer. Am J Cancer Res. 2018; 8(9):1837-1846. PMID: 30323975; PMCID: PMC6176188.
      Citations: 27     
    198. Cha JH, Yang WH, Xia W, Wei Y, Chan LC, Lim SO, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y, Litton JK, Mittendorf EA, Moulder SL, Symmans WF, Thompson AM, Piwnica-Worms H, Chen CH, Khoo KH, Hung MC. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Mol Cell. 2018 08 16; 71(4):606-620.e7. PMID: 30118680; PMCID: PMC6786495.
      Citations: 177     Fields:    Translation:HumansAnimalsCells
    199. Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, Qiao Y, Sharma A, Zhang M, Hung MC, Lin SH. Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer. Clin Cancer Res. 2018 11 15; 24(22):5744-5756. PMID: 30068711.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    200. Li CW, Lai YJ, Hsu JL, Hung MC. Activation of phagocytosis by immune checkpoint blockade. Front Med. 2018 Aug; 12(4):473-480. PMID: 30062558; PMCID: PMC6941417.
      Citations: 9     Fields:    Translation:HumansCells
    201. Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V, Putluri N, Coarfa C, Sreekumar A, Park PK, Nguyen TK, Wang S, Zhou J, Zhou Y, Marks JR, Hawke DH, Hung MC, Yang L, Han L, Ying H, Lin C. Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res. 2018 08 15; 78(16):4524-4532. PMID: 29967256; PMCID: PMC6126676.
      Citations: 32     Fields:    Translation:HumansCells
    202. Sun LL, Yang RY, Li CW, Chen MK, Shao B, Hsu JM, Chan LC, Yang Y, Hsu JL, Lai YJ, Hung MC. Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing. Am J Cancer Res. 2018; 8(7):1307-1316. PMID: 30094103; PMCID: PMC6079156.
      Citations: 43     
    203. Yang Y, Li CW, Chan LC, Wei Y, Hsu JM, Xia W, Cha JH, Hou J, Hsu JL, Sun L, Hung MC. Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res. 2018 08; 28(8):862-864. PMID: 29959401; PMCID: PMC6082826.
      Citations: 136     Fields:    Translation:HumansAnimalsCells
    204. Chou CK, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J, Hung MC. A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues. Biosens Bioelectron. 2018 Oct 15; 117:97-103. PMID: 29890396.
      Citations: 2     Fields:    Translation:HumansCells
    205. Yang WH, Cha JH, Xia W, Lee HH, Chan LC, Wang YN, Hsu JL, Ren G, Hung MC. Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression. Cancer Res. 2018 07 15; 78(14):3761-3768. PMID: 29789418; PMCID: PMC6050079.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    206. Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, Ren GX, Hung MC. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 2018 05 15; 9(1):1908. PMID: 29765039; PMCID: PMC5954021.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    207. Xu A, Zhou R, Tu J, Huo Z, Zhu D, Wang D, Gingold JA, Mata H, Rao PH, Liu M, Mohamed AMT, Kong CSL, Jewell BE, Xia W, Zhao R, Hung MC, Lee DF. Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing. Stem Cell Res. 2018 05; 29:215-219. PMID: 29730572; PMCID: PMC6021017.
      Citations: 2     Fields:    Translation:HumansCells
    208. Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H, Hung MC, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology. 2018 06; 67(6):2226-2243. PMID: 29171033.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    209. Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep. 2018 Apr 17; 23(3):823-837. PMID: 29669287; PMCID: PMC5933875.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    210. Wang YN, Lee HH, Chou CK, Yang WH, Wei Y, Chen CT, Yao J, Hsu JL, Zhu C, Ying H, Ye Y, Wang WJ, Lim SO, Xia W, Ko HW, Liu X, Liu CG, Wu X, Wang H, Li D, Prakash LR, Katz MH, Kang Y, Kim M, Fleming JB, Fogelman D, Javle M, Maitra A, Hung MC. Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer. Cancer Cell. 2018 04 09; 33(4):752-769.e8. PMID: 29606349; PMCID: PMC5893359.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    211. Chen YH, Chung CC, Liu YC, Lai WC, Lin ZS, Chen TM, Li LY, Hung MC. YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts. Am J Cancer Res. 2018; 8(3):514-525. PMID: 29637005; PMCID: PMC5883100.
      Citations: 7     
    212. Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 2018 02 12; 33(2):187-201.e10. PMID: 29438695; PMCID: PMC5824730.
      Citations: 151     Fields:    Translation:HumansAnimalsCells
    213. Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J, Xia W, Rao PH, Hung MC, Zhao R, Lee DF. A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing. Stem Cell Res. 2018 03; 27:131-135. PMID: 29414603.
      Citations: 4     Fields:    Translation:HumansCells
    214. Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M, Hung MC, Wei W. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Mol Cell. 2018 01 18; 69(2):279-291.e5. PMID: 29351847; PMCID: PMC5777296.
      Citations: 59     Fields:    Translation:HumansAnimalsCells
    215. Smith B, Hsu YH, Flores R, Gagea M, Craig S, Hung MC. Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy. Am J Cancer Res. 2018; 8(1):183-191. PMID: 29416931; PMCID: PMC5794732.
      Citations: 1     
    216. Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS. HIF-1a promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest. 2018 02 01; 128(2):625-643. PMID: 29251629; PMCID: PMC5785260.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    217. Korphaisarn K, Chou CK, Xia WY, Clarke CN, Katkhuda R, Davis JS, Raghav KP, Liao HW, Wu JY, Menter DG, Maru DM, Hung MC, Kopetz S. Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment. Am J Cancer Res. 2017; 7(12):2587-2599. PMID: 29312811; PMCID: PMC5752698.
      Citations: 2     
    218. Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH, Hung MC, Huang MT, Su JL. Erratum to: E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer. Ann Surg Oncol. 2017 12; 24(Suppl 3):685-686. PMID: 28160139.
      Citations:    Fields:    
    219. Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest. 2017 12 01; 127(12):4498-4515. PMID: 29130936; PMCID: PMC5707156.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    220. Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A, Lim SO, Howells K, Haddad V, Gomez D, Tran H, Pena GA, Sequist LV, Yang JC, Wang J, Kim ES, Herbst R, Lee JJ, Hong WK, Wistuba I, Hung MC, Sood AK, Heymach JV. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with ?-blockers. Sci Transl Med. 2017 Nov 08; 9(415). PMID: 29118262; PMCID: PMC5870120.
      Citations: 47     Fields:    Translation:HumansCells
    221. Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly. Theranostics. 2017; 7(19):4805-4824. PMID: 29187905; PMCID: PMC5706101.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    222. Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Puerta Martinez F, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation. Mol Cell Biol. 2017 Nov 01; 37(21). PMID: 28760776; PMCID: PMC5640814.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    223. Yang R, Hung MC. The role of T-cell immunoglobulin mucin-3 and its ligand galectin-9 in antitumor immunity and cancer immunotherapy. Sci China Life Sci. 2017 Oct; 60(10):1058-1064. PMID: 29027155.
      Citations: 4     Fields:    Translation:HumansCells
    224. Li CW, Lim SO, Hsu JL, Hung MC. Rational combination of immunotherapy for triple negative breast cancer treatment. Chin Clin Oncol. 2017 Oct; 6(5):54. PMID: 29129094.
      Citations: 6     Fields:    Translation:Humans
    225. Yamaguchi H, Du Y, Nakai K, Ding M, Chang SS, Hsu JL, Yao J, Wei Y, Nie L, Jiao S, Chang WC, Chen CH, Yu Y, Hortobagyi GN, Hung MC. EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. Oncogene. 2018 01 11; 37(2):208-217. PMID: 28925391; PMCID: PMC5786281.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    226. Yi P, Wang Z, Feng Q, Chou CK, Pintilie GD, Shen H, Foulds CE, Fan G, Serysheva I, Ludtke SJ, Schmid MF, Hung MC, Chiu W, O'Malley BW. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4. PMID: 28844863; PMCID: PMC5657569.
      Citations: 33     Fields:    Translation:HumansCells
    227. Huang PJ, Chou CK, Chen CT, Yamaguchi H, Qu J, Muliana A, Hung MC, Kameoka J. Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles. Soft Robot. 2017 Dec; 4(4):390-399. PMID: 29251562.
      Citations: 1     Fields:    
    228. Nakai K, Xia W, Liao HW, Saito M, Hung MC, Yamaguchi H. The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells. Breast Cancer. 2018 Jan; 25(1):74-80. PMID: 28643125.
      Citations: 16     Fields:    Translation:HumansCells
    229. Liao HW, Hung MC. Intracaecal Orthotopic Colorectal Cancer Xenograft Mouse Model. Bio Protoc. 2017 Jun 05; 7(11). PMID: 29104894; PMCID: PMC5667914.
      Citations: 6     
    230. Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells. Int J Cancer. 2017 06 01; 140(11):2517-2525. PMID: 28214331.
      Citations: 8     Fields:    Translation:HumansCells
    231. Chen CT, Chen YC, Du Y, Han Z, Ying H, Bouchard RR, Hsu JL, Hsu JM, Mitcham TM, Chen MK, Sun HL, Chang SS, Li D, Chang P, DePinho RA, Hung MC. A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. Am J Cancer Res. 2017; 7(3):657-672. PMID: 28401019; PMCID: PMC5385650.
      Citations: 3     
    232. Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J, Hung MC, DePinho RA, Huang P, Xu RH, Chiao PJ. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun. 2017 02 24; 8:14437. PMID: 28232723; PMCID: PMC5333128.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    233. Hu J, Bernatchez C, Zhang L, Xia X, Kleinerman ES, Hung MC, Hwu P, Li S. Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases. Cancer Immunol Res. 2017 04; 5(4):300-311. PMID: 28223282; PMCID: PMC5382872.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    234. Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y, Yao J, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J, Hung MC, Liang H, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to?hyperactivate AKT?and confer resistance to AKT?inhibitors. Nat Cell Biol. 2017 03; 19(3):238-251. PMID: 28218907; PMCID: PMC5332298.
      Citations: 100     Fields:    Translation:HumansCells
    235. Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK, Hung MC, Yang MH. Lymphotoxin-? Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4388-4401. PMID: 28196873.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    236. Jiao S, Xia W, Yamaguchi H, Wei Y, Chen MK, Hsu JM, Hsu JL, Yu WH, Du Y, Lee HH, Li CW, Chou CK, Lim SO, Chang SS, Litton J, Arun B, Hortobagyi GN, Hung MC. PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression. Clin Cancer Res. 2017 Jul 15; 23(14):3711-3720. PMID: 28167507; PMCID: PMC5511572.
      Citations: 311     Fields:    Translation:HumansAnimalsCells
    237. Vila IK, Yao Y, Kim G, Xia W, Kim H, Kim SJ, Park MK, Hwang JP, Hung MC, Song SJ, Song MS, Gonz?lez-Billalabeitia E. A UBE2O-AMPKa2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 02 13; 31(2):208-224. PMID: 28162974; PMCID: PMC5463996.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    238. Zhao X, Guo Y, Jiang C, Chang Q, Zhang S, Luo T, Zhang B, Jia X, Hung MC, Dong C, Lin X. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. Nat Med. 2017 Mar; 23(3):337-346. PMID: 28112734; PMCID: PMC5592785.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    239. Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park PK, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, Hung MC, Gallick GE, Han L, Lin C, Yang L. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol. 2017 02; 19(2):106-119. PMID: 28114269; PMCID: PMC5336186.
      Citations: 131     Fields:    Translation:HumansCells
    240. Zuo X, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M, Eng C, Kopetz S, Maru DM, Rashid A, Broaddus R, Wei D, Hung MC, Sood AK, Shureiqi I. Metastasis regulation by PPARD expression in cancer cells. JCI Insight. 2017 01 12; 2(1):e91419. PMID: 28097239; PMCID: PMC5214933.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    241. Liu CC, Lin SP, Hsu HS, Yang SH, Lin CH, Yang MH, Hung MC, Hung SC. Erratum: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016 12 22; 7:14027. PMID: 28004659; PMCID: PMC5196036.
      Citations: 1     Fields:    
    242. Niu N, Zhang J, Zhang N, Mercado-Uribe I, Tao F, Han Z, Pathak S, Multani AS, Kuang J, Yao J, Bast RC, Sood AK, Hung MC, Liu J. Linking genomic reorganization to tumor initiation via the giant cell cycle. Oncogenesis. 2016 Dec 19; 5(12):e281. PMID: 27991913; PMCID: PMC5177773.
      Citations: 52     
    243. Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH, Hung MC, Sarbassov D, Lin HK. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1a activation, tumorigenesis and?metastasis. Nat Cell Biol. 2017 Jan; 19(1):38-51. PMID: 27918549; PMCID: PMC5441459.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    244. Hsu JL, Hung MC. The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer. Cancer Metastasis Rev. 2016 12; 35(4):575-588. PMID: 27913999; PMCID: PMC5215954.
      Citations: 77     Fields:    Translation:Humans
    245. Long Y, Tsai WB, Wang D, Hawke DH, Savaraj N, Feun LG, Hung MC, Chen HH, Kuo MT. Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. Cancer Lett. 2017 03 01; 388:54-63. PMID: 27913198.
      Citations: 9     Fields:    Translation:HumansCells
    246. Lim SO, Li CW, Xia W, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL, Yamaguchi H, Ding Q, Wang Y, Yang Y, Chen CH, Sahin AA, Yu D, Hortobagyi GN, Hung MC. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 2016 Dec 12; 30(6):925-939. PMID: 27866850; PMCID: PMC5171205.
      Citations: 240     Fields:    Translation:HumansAnimalsCells
    247. Liu YL, Perillo EP, Liu C, Yu P, Chou CK, Hung MC, Dunn AK, Yeh HC. Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope: An Application to EGFR Trafficking. Biophys J. 2016 Nov 15; 111(10):2214-2227. PMID: 27851944; PMCID: PMC5112935.
      Citations: 12     Fields:    Translation:HumansCells
    248. Sun HL, Cui R, Zhou J, Teng KY, Hsiao YH, Nakanishi K, Fassan M, Luo Z, Shi G, Tili E, Kutay H, Lovat F, Vicentini C, Huang HL, Wang SW, Kim T, Zanesi N, Jeon YJ, Lee TJ, Guh JH, Hung MC, Ghoshal K, Teng CM, Peng Y, Croce CM. ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. Cancer Cell. 2016 Nov 14; 30(5):723-736. PMID: 27846390; PMCID: PMC5127275.
      Citations: 57     Fields:    Translation:HumansCells
    249. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Corrigendum: Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 10 06; 22(10):1192. PMID: 27711065.
      Citations: 1     Fields:    
    250. Wang Y, Hsu JM, Kang Y, Wei Y, Lee PC, Chang SJ, Hsu YH, Hsu JL, Wang HL, Chang WC, Li CW, Liao HW, Chang SS, Xia W, Ko HW, Chou CK, Fleming JB, Wang H, Hwang RF, Chen Y, Qin J, Hung MC. Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Res. 2016 12 01; 76(23):7049-7058. PMID: 27758883; PMCID: PMC5135656.
      Citations: 24     Fields:    Translation:HumansCells
    251. Lee CJ, Hsu LS, Yue CH, Lin H, Chiu YW, Lin YY, Huang CY, Hung MC, Liu JY. MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Ca-based triple-negative breast cancer cells. Oncotarget. 2016 Sep 13; 7(37):59845-59859. PMID: 27542222; PMCID: PMC5312353.
      Citations: 8     Fields:    Translation:HumansCells
    252. Hung MC, Yang R, Sun Y. Powering Tumor Metastasis with Recycled Fuel. Cancer Cell. 2016 09 12; 30(3):374-375. PMID: 27622330.
      Citations: 1     Fields:    Translation:HumansCells
    253. Chang SS, Yamaguchi H, Xia W, Lim SO, Khotskaya Y, Wu Y, Chang WC, Liu Q, Hung MC. Aurora A kinase activates YAP signaling in triple-negative breast cancer. Oncogene. 2017 03 02; 36(9):1265-1275. PMID: 27593935.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    254. Ko HW, Lee HH, Huo L, Xia W, Yang CC, Hsu JL, Li LY, Lai CC, Chan LC, Cheng CC, Labaff AM, Liao HW, Lim SO, Li CW, Wei Y, Nie L, Yamaguchi H, Hung MC. GSK3? inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget. 2016 Aug 30; 7(35):57131-57144. PMID: 27494834; PMCID: PMC5302978.
      Citations: 20     Fields:    Translation:HumansCells
    255. Li CW, Lim SO, Xia W, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Ding Q, Wang Y, Yao J, Lee CC, Wu HJ, Sahin AA, Allison JP, Yu D, Hortobagyi GN, Hung MC. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nat Commun. 2016 08 30; 7:12632. PMID: 27572267; PMCID: PMC5013604.
      Citations: 292     Fields:    Translation:HumansAnimalsCells
    256. Chen CK, Yu WH, Cheng TY, Chen MW, Su CY, Yang YC, Kuo TC, Lin MT, Huang YC, Hsiao M, Hua KT, Hung MC, Kuo ML. Inhibition of VEGF165/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis. Sci Rep. 2016 08 10; 6:31398. PMID: 27507763; PMCID: PMC4979047.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    257. Nakai K, Hung MC, Yamaguchi H. A perspective on anti-EGFR therapies targeting triple-negative breast cancer. Am J Cancer Res. 2016; 6(8):1609-23. PMID: 27648353; PMCID: PMC5004067.
      Citations: 122     
    258. Chen YH, Chung CC, Liu YC, Yeh SP, Hsu JL, Hung MC, Su HL, Li LY. Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes. Stem Cells. 2016 08; 34(8):2183-93. PMID: 27250566.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    259. Liu CC, Lin SP, Hsu HS, Yang SH, Lin CH, Yang MH, Hung MC, Hung SC. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016 06 16; 7:11798. PMID: 27306323; PMCID: PMC4912642.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    260. Chang CC, Zhang C, Zhang Q, Sahin O, Wang H, Xu J, Xiao Y, Zhang J, Rehman SK, Li P, Hung MC, Behbod F, Yu D. Upregulation of lactate dehydrogenase a by 14-3-3? leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. 2016 Jun 07; 7(23):35270-83. PMID: 27150057; PMCID: PMC5085227.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    261. Rojas A, Zhang P, Wang Y, Foo WC, Xiao L, Wang J, Gores GJ, Hung MC, Blechacz B, Mu?oz NM. A Positive TGF-?/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer. Neoplasia. 2016 06; 18(6):371-86. PMID: 27292026; PMCID: PMC4909706.
      Citations: 16     Fields:    Translation:HumansCells
    262. Chang TY, Chen HA, Chiu CF, Chang YW, Kuo TC, Tseng PC, Wang W, Hung MC, Su JL. Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL. Cancer Res. 2016 07 01; 76(13):3916-28. PMID: 27216190.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    263. Chou CK, Fan CC, Lin PS, Liao PY, Tung JC, Hsieh CH, Hung MC, Chen CH, Chang WC. Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. Oncotarget. 2016 May 03; 7(18):25742-54. PMID: 27013588; PMCID: PMC5041940.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    264. Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, Filant J, Ehsanipour EA, Herbrich SM, Maiti SN, Huang L, Kim JH, Zhang X, Han HD, Armaiz-Pena GN, Seviour EG, Tucker S, Zhang M, Yang D, Cooper LJ, Ali-Fehmi R, Bar-Eli M, Lee JS, Ram PT, Baggerly KA, Lopez-Berestein G, Hung MC, Sood AK. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nat Commun. 2016 Apr 04; 7:11169. PMID: 27041221; PMCID: PMC4822037.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    265. Yao J, Huang Y, Lin C, Rimoldi D, Behren A, Cebon JS, Hung MC, Weinstein JN, Strausberg RL, Zhao Q, Caballero OL. Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity. Cancer Immunol Res. 2016 06; 4(6):552-61. PMID: 27045022.
      Citations: 33     Fields:    Translation:HumansCells
    266. Chou CK, Tsou PH, Hsu JL, Lee HH, Wang YN, Kameoka J, Hung MC. Analysis of Individual Signaling Complexes by mMAPS, a Flow-Proteometric System. Curr Protoc Mol Biol. 2016 Apr 01; 114:20.11.1-20.11.22. PMID: 27038387; PMCID: PMC4830480.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    267. Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv. 2016 04; 2(4):e1501290. PMID: 27757426; PMCID: PMC5065225.
      Citations: 15     Fields:    Translation:HumansCells
    268. Chen MK, Hung MC. Regulation of therapeutic resistance in cancers by receptor tyrosine kinases. Am J Cancer Res. 2016; 6(4):827-42. PMID: 27186434; PMCID: PMC4859887.
      Citations: 9     
    269. Hsu MC, Hung WC, Yamaguchi H, Lim SO, Liao HW, Tsai CH, Hung MC. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. Am J Cancer Res. 2016; 6(3):628-38. PMID: 27152240; PMCID: PMC4851842.
      Citations: 21     
    270. Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Liu B, Shi Q, Lam EW, Hung MC, Liu Q. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016 Jan 19; 7:10180. PMID: 26782714; PMCID: PMC4735655.
      Citations: 63     Fields:    Translation:HumansCells
    271. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 Feb; 22(2):194-201. PMID: 26779812; PMCID: PMC4754671.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    272. Lim SO, Li CW, Xia W, Lee HH, Chang SS, Shen J, Hsu JL, Raftery D, Djukovic D, Gu H, Chang WC, Wang HL, Chen ML, Huo L, Chen CH, Wu Y, Sahin A, Hanash SM, Hortobagyi GN, Hung MC. EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape. Cancer Res. 2016 Mar 01; 76(5):1284-96. PMID: 26759242; PMCID: PMC4775355.
      Citations: 87     Fields:    Translation:HumansAnimalsCells
    273. Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, Wang Y, Chou CK, Hsu JM, Lai YJ, LaBaff AM, Ding Q, Ko HW, Tsai FJ, Tsai CH, Hortobagyi GN, Hung MC. AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res. 2016 Mar 15; 76(6):1451-62. PMID: 26759241; PMCID: PMC4794388.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    274. Wang C, Hu Z, Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Zhou Y, Marks JR, Liang H, Hung MC, Lin C, Yang L. The LINK-A lncRNA activates normoxic HIF1a signalling in triple-negative breast cancer. Nat Cell Biol. 2016 Feb; 18(2):213-24. PMID: 26751287; PMCID: PMC4791069.
      Citations: 222     Fields:    Translation:HumansAnimalsCells
    275. Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG. JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis. Cancer Res. 2016 Feb 15; 76(4):831-43. PMID: 26747897; PMCID: PMC4755879.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    276. Wu TJ, Chang SS, Li CW, Hsu YH, Chen TC, Lee WC, Yeh CT, Hung MC. Severe Hepatitis Promotes Hepatocellular Carcinoma Recurrence via NF-?B Pathway-Mediated Epithelial-Mesenchymal Transition after Resection. Clin Cancer Res. 2016 Apr 01; 22(7):1800-12. PMID: 26655845; PMCID: PMC4818680.
      Citations: 12     Fields:    Translation:HumansCells
    277. Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest. 2015 Dec; 125(12):4529-43. PMID: 26571401; PMCID: PMC4665782.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    278. Lukianova-Hleb EY, Kim YS, Aryasomayajula B, Boulikas T, Phan J, Hung MC, Torchilin VP, O'Neill BE, Lapotko DO. Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model. Am J Cancer Res. 2015; 5(12):3534-47. PMID: 26885444; PMCID: PMC4731629.
      Citations:    
    279. Chen CT, Chen YC, Yamaguchi H, Hung MC. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015; 5(12):3560-9. PMID: 26885446; PMCID: PMC4731631.
      Citations: 8     
    280. Rahal OM, Nie L, Chan LC, Li CW, Hsu YH, Hsu J, Yu D, Hung MC. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. Am J Cancer Res. 2015; 5(12):3624-34. PMID: 26885451; PMCID: PMC4731636.
      Citations: 1     
    281. Han B, Qu Y, Jin Y, Yu Y, Deng N, Wawrowsky K, Zhang X, Li N, Bose S, Wang Q, Sakkiah S, Abrol R, Jensen TW, Berman BP, Tanaka H, Johnson J, Gao B, Hao J, Liu Z, Buttyan R, Ray PS, Hung MC, Giuliano AE, Cui X. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep. 2015 Nov 03; 13(5):1046-58. PMID: 26565916; PMCID: PMC4806384.
      Citations: 64     Fields:    Translation:HumansCells
    282. Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK, Armaiz-Pe?a GN. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015 Nov 09; 28(5):610-622. PMID: 26481148; PMCID: PMC4643364.
      Citations: 38     Fields:    Translation:HumansAnimalsCells
    283. Yang PW, Chiang TH, Hsieh CY, Huang YC, Wong LF, Hung MC, Tsai JC, Lee JM. The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2015 Dec; 30(9):2353-61. PMID: 26450615.
      Citations: 5     Fields:    Translation:HumansCells
    284. Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I, Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015 Sep 30; 6:8419. PMID: 26420673; PMCID: PMC4598737.
      Citations: 51     Fields:    Translation:HumansCells
    285. Chen WS, Yen CJ, Chen YJ, Chen JY, Wang LY, Chiu SJ, Shih WL, Ho CY, Wei TT, Pan HL, Chien PH, Hung MC, Chen CC, Huang WC. miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. Oncotarget. 2015 Sep 22; 6(28):25962-74. PMID: 26296971; PMCID: PMC4694878.
      Citations: 21     Fields:    Translation:HumansCells
    286. Lee HH, Wang YN, Hung MC. Non-canonical signaling mode of the epidermal growth factor receptor family. Am J Cancer Res. 2015; 5(10):2944-58. PMID: 26693051; PMCID: PMC4656722.
      Citations: 25     
    287. Dai HY, Chen HY, Lai WC, Hung MC, Li LY. Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma. Oncotarget. 2015 Sep 15; 6(27):23807-19. PMID: 26247632; PMCID: PMC4695153.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    288. Perillo EP, Liu YL, Huynh K, Liu C, Chou CK, Hung MC, Yeh HC, Dunn AK. Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination. Nat Commun. 2015 Jul 29; 6:7874. PMID: 26219252; PMCID: PMC4532916.
      Citations: 34     Fields:    Translation:HumansCells
    289. Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. 2016 04 28; 35(17):2186-96. PMID: 26212011; PMCID: PMC4792786.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    290. Chen MK, Hung MC. Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases. FEBS J. 2015 Oct; 282(19):3693-721. PMID: 26096795; PMCID: PMC4591179.
      Citations: 34     Fields:    Translation:HumansCells
    291. Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P, Fuentes-Mattei E, Kahraman N, Pradeep S, Ozpolat B, Tucker S, Hung MC, Baggerly K, Bartholomeusz G, Calin G, Sood AK, Lopez-Berestein G. The ZNF304-integrin axis protects against anoikis in cancer. Nat Commun. 2015 Jun 17; 6:7351. PMID: 26081979; PMCID: PMC4830335.
      Citations: 29     Fields:    Translation:HumansCells
    292. Yang CC, LaBaff A, Wei Y, Nie L, Xia W, Huo L, Yamaguchi H, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, Chan LC, Yao J, Kleer CG, Hortobagyi GN, Hung MC. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. Am J Transl Res. 2015; 7(6):1009-20. PMID: 26279746; PMCID: PMC4532735.
      Citations: 23     
    293. Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Res. 2015 May 01; 75(9):1846-58. PMID: 25877877; PMCID: PMC4417433.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    294. Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R, Hung MC, Schaniel C, Lemischka IR. Modeling familial cancer with induced pluripotent stem cells. Cell. 2015 Apr 09; 161(2):240-54. PMID: 25860607; PMCID: PMC4397979.
      Citations: 88     Fields:    Translation:HumansAnimalsCells
    295. Zuo M, Rashid A, Churi C, Vauthey JN, Chang P, Li Y, Hung MC, Li D, Javle M. Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer. Br J Cancer. 2015 Mar 17; 112(6):1042-51. PMID: 25742482; PMCID: PMC4366884.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    296. Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, Wu TT, Johnson RL, Hung MC, Ajani JA. The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. Clin Cancer Res. 2015 Jun 01; 21(11):2580-90. PMID: 25739674; PMCID: PMC4452384.
      Citations: 106     Fields:    Translation:HumansAnimalsCells
    297. Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Proteasome inhibition enhances the killing effect of BikDD gene therapy. Am J Transl Res. 2015; 7(2):319-27. PMID: 25901200; PMCID: PMC4399095.
      Citations: 2     
    298. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. 14-3-3? turns TGF-?'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015 Feb 09; 27(2):177-92. PMID: 25670079; PMCID: PMC4325275.
      Citations: 88     Fields:    Translation:HumansCells
    299. Shen J, Hung MC. Signaling-mediated regulation of MicroRNA processing. Cancer Res. 2015 Mar 01; 75(5):783-91. PMID: 25660948; PMCID: PMC4348149.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    300. Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, Hung MC. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res. 2015 Feb; 25(2):225-36. PMID: 25601159; PMCID: PMC4650576.
      Citations: 26     Fields:    Translation:HumansCells
    301. Wang YN, Huo L, Hsu JL, Hung MC. Biochemical fractionation of membrane receptors in the nucleus. Methods Mol Biol. 2015; 1234:99-112. PMID: 25304351.
      Citations: 2     Fields:    Translation:Cells
    302. Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, Mishra L, Hung MC. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. Am J Transl Res. 2014; 6(6):649-63. PMID: 25628777; PMCID: PMC4297334.
      Citations: 14     
    303. Chang YW, Chen HA, Tseng CF, Hong CC, Ma JT, Hung MC, Wu CH, Huang MT, Su JL. De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells. Oncotarget. 2014 Nov 15; 5(21):10558-70. PMID: 25301734; PMCID: PMC4279393.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    304. Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 2014 Nov 20; 159(5):1110-1125. PMID: 25416949; PMCID: PMC4266991.
      Citations: 214     Fields:    Translation:HumansAnimalsCells
    305. Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ. HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Mol Oncol. 2015 Mar; 9(3):586-600. PMID: 25435280; PMCID: PMC4815926.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    306. Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH, Hung MC, Huang MT, Su JL. E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer. Ann Surg Oncol. 2015 Mar; 22(3):889-98. PMID: 25212833.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    307. Hong CC, Chen PS, Chiou J, Chiu CF, Yang CY, Hsiao M, Chang YW, Yu YH, Hung MC, Hsu NW, Shiah SG, Hsu NY, Su JL. miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression. Cancer Res. 2014 Nov 01; 74(21):6280-90. PMID: 25205106.
      Citations: 16     Fields:    Translation:HumansCells
    308. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep; 16(9):864-75. PMID: 25086746; PMCID: PMC4150825.
      Citations: 187     Fields:    Translation:HumansAnimalsCells
    309. Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC. MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Sci Signal. 2014 Jul 29; 7(336):ra71. PMID: 25074979; PMCID: PMC4161976.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    310. Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Wang HL, Kuo SC, Chen CH, Yu YL, Hung MC. EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell. 2014 Jul 28; 30(2):224-37. PMID: 25073158; PMCID: PMC4149291.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    311. Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC, Sher YP. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Res. 2014 Sep 15; 74(18):5229-43. PMID: 25060522.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    312. Debeb BG, Gong Y, Atkinson RL, Sneige N, Huo L, Gonzalez-Angulo AM, Hung MC, Valero V, Ueno NT, Woodward WA. EZH2 expression correlates with locoregional recurrence after radiation in inflammatory breast cancer. J Exp Clin Cancer Res. 2014 Jul 23; 33:58. PMID: 25051981; PMCID: PMC4431485.
      Citations: 11     Fields:    Translation:Humans
    313. Khotskaya YB, Goverdhan A, Shen J, Ponz-Sarvise M, Chang SS, Hsu MC, Wei Y, Xia W, Yu D, Hung MC. S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. Am J Transl Res. 2014; 6(4):361-76. PMID: 25075253; PMCID: PMC4113498.
      Citations: 26     
    314. Yamaguchi H, Hung MC. Regulation and Role of EZH2 in Cancer. Cancer Res Treat. 2014 Jul; 46(3):209-22. PMID: 25038756; PMCID: PMC4132442.
      Citations: 129     Fields:    
    315. Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, Sahin AA, Sood A, Mills GB, Yu D, Hortobagyi GN, Hung MC. Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res. 2014 Sep 01; 74(17):4822-35. PMID: 24970481; PMCID: PMC4154991.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    316. Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest. 2014 Jul; 124(7):3093-106. PMID: 24911147; PMCID: PMC4071406.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    317. Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, Hung MC, Johnson RL. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 2014 Aug 01; 74(15):4170-82. PMID: 24906622; PMCID: PMC4136429.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    318. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell. 2014 Jun 19; 54(6):960-974. PMID: 24857548; PMCID: PMC4067806.
      Citations: 119     Fields:    Translation:HumansAnimalsCells
    319. Xie X, Kong Y, Tang H, Yang L, Hsu JL, Hung MC. Targeted BikDD expression kills androgen-dependent and castration-resistant prostate cancer cells. Mol Cancer Ther. 2014 Jul; 13(7):1813-25. PMID: 24785255; PMCID: PMC4120838.
      Citations: 8     Fields:    Translation:HumansAnimals
    320. Yan M, Zhang Y, He B, Xiang J, Wang ZF, Zheng FM, Xu J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, Wang J, Wang Y, Li LH, Zeng YX, Lam EW, Hung MC, Liu Q. IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nat Commun. 2014 Apr 17; 5:3661. PMID: 24739462.
      Citations: 38     Fields:    Translation:HumansCells
    321. Chou CK, Lee HH, Tsou PH, Chen CT, Hsu JM, Yamaguchi H, Wang YN, Lee HJ, Hsu JL, Lee JF, Kameoka J, Hung MC. mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes. Sci Signal. 2014 Mar 04; 7(315):rs1. PMID: 24595109; PMCID: PMC4120848.
      Citations: 4     Fields:    Translation:Cells
    322. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya-Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet. 2014 Feb; 10(2):e1004177. PMID: 24586203; PMCID: PMC3937226.
      Citations: 63     Fields:    Translation:HumansAnimalsCells
    323. Zhang K, Chou CK, Xia X, Hung MC, Qin L. Block-Cell-Printing for live single-cell printing. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):2948-53. PMID: 24516129; PMCID: PMC3939871.
      Citations: 40     Fields:    Translation:Cells
    324. Chang YW, Hung MC, Su JL. The anti-tumor activity of E1A and its implications in cancer therapy. Arch Immunol Ther Exp (Warsz). 2014 Jun; 62(3):195-204. PMID: 24504082.
      Citations: 8     Fields:    Translation:HumansAnimals
    325. Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Hung MC, Huang S, Medema RH. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-?-dependent cancer metastasis. J Clin Invest. 2014 Feb; 124(2):564-79. PMID: 24382352; PMCID: PMC3904622.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    326. Chiou GY, Chien CS, Wang ML, Chen MT, Yang YP, Yu YL, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI, Chen KH, Liu DM, Miller SA, Chen YW, Huang PI, Shih YH, Hung MC, Chiou SH. Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma. Mol Cell. 2013 Dec 12; 52(5):693-706. PMID: 24332177.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    327. Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec; 15(12):1486-1494. PMID: 24270891; PMCID: PMC3951854.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    328. Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach JV, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013 Dec; 123(12):5231-46. PMID: 24200691; PMCID: PMC3859406.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    329. Shen J, Wang Y, Hung MC. RASAL2: wrestling in the combat of Ras activation. Cancer Cell. 2013 Sep 09; 24(3):277-9. PMID: 24029223.
      Citations: 5     Fields:    Translation:HumansAnimals
    330. Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT. TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase. Cancer Res. 2013 Nov 01; 73(21):6516-25. PMID: 24014597; PMCID: PMC6135947.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    331. Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, Hung MC. Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. PLoS One. 2013; 8(9):e73406. PMID: 24039934; PMCID: PMC3764163.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    332. Khotskaya YB, Beck BH, Hurst DR, Han Z, Xia W, Hung MC, Welch DR. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Mol Carcinog. 2014 Dec; 53(12):1011-26. PMID: 24000122; PMCID: PMC3939074.
      Citations: 9     Fields:    Translation:HumansCells
    333. Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13. PMID: 23989979; PMCID: PMC3920728.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    334. Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 01; 154(3):556-68. PMID: 23911321; PMCID: PMC3845452.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    335. Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC, Hung MC, Weihua Z. EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. Prostate. 2013 Sep; 73(13):1453-61. PMID: 23765757.
      Citations: 23     Fields:    Translation:HumansCells
    336. Huang TH, Huo L, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH, Hung MC. Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell. 2013 Jun 10; 23(6):796-810. PMID: 23764002; PMCID: PMC3703149.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    337. Chen CT, Hung MC. Beyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapy. Am J Transl Res. 2013; 5(4):393-403. PMID: 23724163; PMCID: PMC3665913.
      Citations: 18     
    338. Huang WC, Hsu SC, Huang SJ, Chen YJ, Hsiao YC, Zhang W, Fidler IJ, Hung MC. Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis. Am J Transl Res. 2013; 5(4):441-9. PMID: 23724167; PMCID: PMC3665917.
      Citations: 5     
    339. Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, Liu CG, Patel DJ, Hung MC. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature. 2013 May 16; 497(7449):383-7. PMID: 23636329; PMCID: PMC3717558.
      Citations: 185     Fields:    Translation:HumansCells
    340. Yu YL, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC, Hung MC. Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. PLoS One. 2013; 8(4):e61362. PMID: 23593472; PMCID: PMC3620387.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    341. Yamaguchi H, Chang SS, Hsu JL, Hung MC. Signaling cross-talk in the resistance to HER family receptor targeted therapy. Oncogene. 2014 Feb 27; 33(9):1073-81. PMID: 23542173; PMCID: PMC3874419.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    342. Yu YL, Chou RH, Shyu WC, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC, Hung MC. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Mol Med. 2013 Apr; 5(4):531-47. PMID: 23526793; PMCID: PMC3628108.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    343. Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013 Mar 18; 23(3):316-31. PMID: 23453623; PMCID: PMC3703516.
      Citations: 367     Fields:    Translation:HumansAnimalsCells
    344. Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP, Wang YN, Yamaguchi H, Miller SA, Hung MC. Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene. 2014 Feb 06; 33(6):756-70. PMID: 23376851; PMCID: PMC3874427.
      Citations: 31     Fields:    Translation:HumansCells
    345. Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87. PMID: 23388826; PMCID: PMC3576513.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    346. Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY, Hung MC, Huang WC. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Mol Pharmacol. 2013 Apr; 83(4):857-69. PMID: 23355539.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    347. Yamaguchi H, Hsu JL, Chen CT, Wang YN, Hsu MC, Chang SS, Du Y, Ko HW, Herbst R, Hung MC. Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res. 2013 Feb 15; 19(4):845-54. PMID: 23344263; PMCID: PMC3703145.
      Citations: 36     Fields:    Translation:HumansCells
    348. Huang WC, Hung MC. Beyond NF-?B activation: nuclear functions of I?B kinase a. J Biomed Sci. 2013 Jan 23; 20:3. PMID: 23343355; PMCID: PMC3563485.
      Citations: 38     Fields:    Translation:HumansCells
    349. Liu CM, Hsieh CL, He YC, Lo SJ, Liang JA, Hsieh TF, Josson S, Chung LW, Hung MC, Sung SY. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. PLoS One. 2013; 8(1):e53795. PMID: 23342005; PMCID: PMC3547060.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    350. Lin SP, Lee YT, Wang JY, Miller SA, Chiou SH, Hung MC, Hung SC. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS One. 2012; 7(11):e49605. PMID: 23185379; PMCID: PMC3502468.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    351. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KKC, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell. 2012 11 09; 151(4):913-914. PMID: 30360292.
      Citations: 15     Fields:    
    352. Chen PS, Su JL, Hung MC. Dysregulation of microRNAs in cancer. J Biomed Sci. 2012 Oct 17; 19:90. PMID: 23075324; PMCID: PMC3482395.
      Citations: 57     Fields:    Translation:Humans
    353. Chen YH, Hung MC, Li LY. EZH2: a pivotal regulator in controlling cell differentiation. Am J Transl Res. 2012; 4(4):364-75. PMID: 23145205; PMCID: PMC3493026.
      Citations: 26     
    354. Li L, Xie X, Luo J, Liu M, Xi S, Guo J, Kong Y, Wu M, Gao J, Xie Z, Tang J, Wang X, Wei W, Yang M, Hung MC, Xie X. Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. Mol Ther. 2012 Dec; 20(12):2326-34. PMID: 23032974; PMCID: PMC3519992.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    355. Lin SP, Lee YT, Yang SH, Miller SA, Chiou SH, Hung MC, Hung SC. Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis. Cancer Lett. 2013 Jan 28; 328(2):226-34. PMID: 23017941.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    356. Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 2012 Oct; 18(10):1511-7. PMID: 23001183; PMCID: PMC3684419.
      Citations: 208     Fields:    Translation:HumansAnimalsCells
    357. Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 2012 Aug 03; 11(2):179-94. PMID: 22862944; PMCID: PMC3413175.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    358. Hung MC. On mammary gland growth factors: roles in normal development and in cancer. Cold Spring Harb Perspect Biol. 2012 Aug 01; 4(8):a013532. PMID: 22855727; PMCID: PMC3405857.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    359. Chen CT, Du Y, Yamaguchi H, Hsu JM, Kuo HP, Hortobagyi GN, Hung MC. Targeting the IKK?/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Mol Cancer Ther. 2012 Oct; 11(10):2212-21. PMID: 22826466; PMCID: PMC3712288.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    360. Yu YL, Chou RH, Wu CH, Wang YN, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH, Hung MC. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J Biol Chem. 2012 Sep 07; 287(37):31015-26. PMID: 22815474; PMCID: PMC3438934.
      Citations: 28     Fields:    Translation:HumansCells
    361. Xie X, Li L, Xiao X, Guo J, Kong Y, Wu M, Liu W, Gao G, Hsu JL, Wei W, Hung MC, Xie X. Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models. Mol Cancer Ther. 2012 Sep; 11(9):1915-24. PMID: 22752427.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    362. Hong S, Tsou PH, Chou CK, Yamaguchi H, Su CB, Hung MC, Kameoka J. Microfluidic three-dimensional hydrodynamic flow focusing for the rapid protein concentration analysis. Biomicrofluidics. 2012 Jun; 6(2):24132. PMID: 23785388; PMCID: PMC3391308.
      Citations: 2     
    363. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 2012 May 25; 149(5):1098-111. PMID: 22632973; PMCID: PMC3586339.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    364. Yang PW, Hung MC, Hsieh CY, Tung EC, Wang YH, Tsai JC, Lee JM. The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2013 Feb; 28(2):605-14. PMID: 22585382.
      Citations: 11     Fields:    Translation:HumansCells
    365. De Wever O, Hendrix A, Lambein K, Land D, Bracke M, Hung MC, Larsen AK, Emami S, Gespach C, Ouelaa-Benslama R, Sabbah M, Pr?vost G. Identification of a GaG??, AKT and PKCa signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition. Int J Oncol. 2012 Jul; 41(1):189-200. PMID: 22552300.
      Citations: 10     Fields:    Translation:HumansCells
    366. Wang YN, Hung MC. Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family. Cell Biosci. 2012 Apr 20; 2(1):13. PMID: 22520625; PMCID: PMC3418567.
      Citations: 68     
    367. Nie L, Wu HJ, Hsu JM, Chang SS, Labaff AM, Li CW, Wang Y, Hsu JL, Hung MC. Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer. Am J Transl Res. 2012; 4(2):127-50. PMID: 22611467; PMCID: PMC3353529.
      Citations: 113     
    368. Huang WC, Chen WS, Chen YJ, Wang LY, Hsu SC, Chen CC, Hung MC. Hepatitis B virus X protein induces IKKa nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells. J Cell Physiol. 2012 Apr; 227(4):1446-54. PMID: 21618535.
      Citations: 18     Fields:    Translation:HumansCells
    369. Wang YN, Lee HH, Lee HJ, Du Y, Yamaguchi H, Hung MC. Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J Biol Chem. 2012 May 11; 287(20):16869-79. PMID: 22451678; PMCID: PMC3351284.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    370. Wang Y, Ding Q, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Hsu JL, Miller SA, Wang X, Lee DF, Hsu JM, Huo L, Labaff AM, Liu D, Huang TH, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y, Wang H, Ajani J, Hung MC. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell. 2012 Mar 20; 21(3):374-87. PMID: 22439934; PMCID: PMC3350095.
      Citations: 197     Fields:    Translation:HumansAnimalsCells
    371. Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012 Mar 11; 14(4):366-74. PMID: 22407364.
      Citations: 115     Fields:    Translation:HumansCells
    372. Yamaguchi H, Hsu JL, Hung MC. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Front Oncol. 2012; 2:15. PMID: 22649777; PMCID: PMC3355968.
      Citations: 28     
    373. Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, Chao CH, Yamaguchi H, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, Yang MH, Hortobagyi GN, Hung MC. Epithelial-mesenchymal transition induced by TNF-a requires NF-?B-mediated transcriptional upregulation of Twist1. Cancer Res. 2012 Mar 01; 72(5):1290-300. PMID: 22253230; PMCID: PMC3350107.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    374. Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/?/NF-?B activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Jan 17; 21(1):105-20. PMID: 22264792; PMCID: PMC3360958.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    375. Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene. 2012 Oct 04; 31(40):4372-83. PMID: 22231447; PMCID: PMC3326223.
      Citations: 30     Fields:    Translation:HumansCells
    376. Zhao H, Ho PC, Lo YH, Espejo A, Bedford MT, Hung MC, Wang SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PLoS One. 2012; 7(1):e29416. PMID: 22238610; PMCID: PMC3251568.
      Citations: 22     Fields:    Translation:HumansCells
    377. Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84. PMID: 22196886; PMCID: PMC3268914.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    378. Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer. 2012 Jan 17; 106(2):243-7. PMID: 22187039; PMCID: PMC3261672.
      Citations: 157     Fields:    Translation:HumansCells
    379. Hung MC, Link W. Protein localization in disease and therapy. J Cell Sci. 2011 Oct 15; 124(Pt 20):3381-92. PMID: 22010196.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    380. Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, Huo L, Cheng X, Chen YJ, Li CW, Jeng LB, Hsu JL, Li LY, Tan A, Curley SA, Ellis LM, Dubois RN, Hung MC. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest. 2011 Nov; 121(11):4526-36. PMID: 21985787; PMCID: PMC3204827.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    381. Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell. 2011 Sep 13; 20(3):341-56. PMID: 21907925; PMCID: PMC3172580.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    382. Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN, Hung MC. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011 Nov 01; 71(21):6878-87. PMID: 21911455; PMCID: PMC3242367.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    383. Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. Eur J Pharmacol. 2011 Nov 16; 670(1):96-104. PMID: 21907193.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    384. Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC. The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. J Natl Cancer Inst. 2011 Sep 21; 103(18):1403-22. PMID: 21813412; PMCID: PMC3176777.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    385. Yang JY, Hung MC. Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets. 2011 Aug; 12(9):1284-90. PMID: 21443462; PMCID: PMC3149891.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    386. Jan CI, Yu CC, Hung MC, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. J Pathol. 2011 Nov; 225(3):424-37. PMID: 21710689.
      Citations: 24     Fields:    Translation:Humans
    387. Chen YJ, Huang WC, Wei YL, Hsu SC, Yuan P, Lin HY, Wistuba II, Lee JJ, Yen CJ, Su WC, Chang KY, Chang WC, Chou TC, Chou CK, Tsai CH, Hung MC. Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells. PLoS One. 2011; 6(6):e21428. PMID: 21731744; PMCID: PMC3121773.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    388. Banerjee A, Lang JY, Hung MC, Sengupta K, Banerjee SK, Baksi K, Banerjee DK. Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin. J Biol Chem. 2011 Aug 19; 286(33):29127-29138. PMID: 21676868; PMCID: PMC3190720.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    389. Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, Hung MC, Hung SC. Mesenchymal stem cells promote formation of colorectal tumors in mice. Gastroenterology. 2011 Sep; 141(3):1046-56. PMID: 21699785.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    390. Chen CT, Yamaguchi H, Lee HJ, Du Y, Lee HH, Xia W, Yu WH, Hsu JL, Yen CJ, Sun HL, Wang Y, Yeh ET, Hortobagyi GN, Hung MC. Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase. Mol Cancer Ther. 2011 Aug; 10(8):1327-36. PMID: 21610170; PMCID: PMC3155219.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    391. Li LY, Chen H, Hsieh YH, Wang YN, Chu HJ, Chen YH, Chen HY, Chien PJ, Ma HT, Tsai HC, Lai CC, Sher YP, Lien HC, Tsai CH, Hung MC. Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res. 2011 Jun 15; 71(12):4269-79. PMID: 21555369; PMCID: PMC3117049.
      Citations: 38     Fields:    Translation:HumansCells
    392. Chou RH, Yu YL, Hung MC. The roles of EZH2 in cell lineage commitment. Am J Transl Res. 2011 May 15; 3(3):243-50. PMID: 21654879; PMCID: PMC3102568.
      Citations: 46     
    393. Huang WC, Chen YJ, Li LY, Wei YL, Hsu SC, Tsai SL, Chiu PC, Huang WP, Wang YN, Chen CH, Chang WC, Chang WC, Chen AJ, Tsai CH, Hung MC. Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J Biol Chem. 2011 Jun 10; 286(23):20558-68. PMID: 21487020; PMCID: PMC3121497.
      Citations: 88     Fields:    Translation:HumansCells
    394. Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y, Lang J, Hung MC, Lin X. CARMA3 is crucial for EGFR-Induced activation of NF-?B and tumor progression. Cancer Res. 2011 Mar 15; 71(6):2183-92. PMID: 21406399; PMCID: PMC3059846.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    395. Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia. 2011 Mar; 13(3):286-98. PMID: 21390191; PMCID: PMC3050871.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    396. Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol. 2011 Mar; 13(3):317-23. PMID: 21336307; PMCID: PMC3075845.
      Citations: 368     Fields:    Translation:HumansCells
    397. Sher YP, Liu SJ, Chang CM, Lien SP, Chen CH, Han Z, Li LY, Chen JS, Wu CW, Hung MC. Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer. Mol Cancer Ther. 2011 Apr; 10(4):637-47. PMID: 21282355.
      Citations: 8     Fields:    Translation:AnimalsCells
    398. Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between Arg?1175 methylation and Tyr?1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol. 2011 Feb; 13(2):174-81. PMID: 21258366; PMCID: PMC3048027.
      Citations: 104     Fields:    Translation:HumansCells
    399. Chen YH, Yeh FL, Yeh SP, Ma HT, Hung SC, Hung MC, Li LY. Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2. J Biol Chem. 2011 Mar 25; 286(12):10671-80. PMID: 21247904; PMCID: PMC3060518.
      Citations: 29     Fields:    Translation:HumansCells
    400. Yu YL, Chou RH, Chen LT, Shyu WC, Hsieh SC, Wu CS, Zeng HJ, Yeh SP, Yang DM, Hung SC, Hung MC. EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling. J Biol Chem. 2011 Mar 18; 286(11):9657-67. PMID: 21216957; PMCID: PMC3059014.
      Citations: 29     Fields:    Translation:HumansCells
    401. Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-?-catenin signaling. Cancer Cell. 2011 Jan 18; 19(1):86-100. PMID: 21215703; PMCID: PMC3041516.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    402. Zhao H, Lo YH, Ma L, Waltz SE, Gray JK, Hung MC, Wang SC. Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth. Mol Cancer Ther. 2011 Jan; 10(1):29-36. PMID: 21220489; PMCID: PMC3066081.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    403. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16; 468(7326):927-32. PMID: 21164480; PMCID: PMC3058826.
      Citations: 205     Fields:    Translation:HumansCells
    404. Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol. 2011 Jan; 13(1):87-94. PMID: 21131960; PMCID: PMC3076036.
      Citations: 195     Fields:    Translation:HumansCells
    405. Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, Horton LW, Zaja-Milatovic S, Collins-Burow BM, Wadsworth S, Beckman BS, Wood CE, Fuqua SA, Nephew KP, Dent P, Worthylake RA, Curiel TJ, Hung MC, Richmond A, Burow ME. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res. 2011 Jan 15; 71(2):603-13. PMID: 21123450; PMCID: PMC3140407.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    406. Song H, Li CW, Labaff AM, Lim SO, Li LY, Kan SF, Chen Y, Zhang K, Lang J, Xie X, Wang Y, Huo LF, Hsu SC, Chen X, Zhao Y, Hung MC. Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors. Biochem Biophys Res Commun. 2011 Jan 07; 404(1):68-73. PMID: 21094134; PMCID: PMC3049249.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    407. Jin Q, Yuan LX, Boulbes D, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJ. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res. 2010; 12(6):R96. PMID: 21080941; PMCID: PMC3046439.
      Citations: 47     Fields:    Translation:HumansCells
    408. Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 2010 Nov 16; 18(5):423-35. PMID: 21075308; PMCID: PMC3022383.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    409. Beyer I, Li Z, Persson J, Liu Y, van Rensburg R, Yumul R, Zhang XB, Hung MC, Lieber A. Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab. Mol Ther. 2011 Mar; 19(3):479-89. PMID: 21081901; PMCID: PMC3048180.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    410. Cheng X, Xia W, Yang JY, Hsu JL, Chou CK, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochem Biophys Res Commun. 2010 Dec 03; 403(1):103-7. PMID: 21040707; PMCID: PMC3001223.
      Citations: 14     Fields:    Translation:HumansAnimals
    411. Wang YN, Yamaguchi H, Huo L, Du Y, Lee HJ, Lee HH, Wang H, Hsu JM, Hung MC. The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem. 2010 Dec 03; 285(49):38720-9. PMID: 20937808; PMCID: PMC2992305.
      Citations: 65     Fields:    Translation:HumansCells
    412. Hong S, Wang YN, Yamaguchi H, Sreenivasappa H, Chou CK, Tsou PH, Hung MC, Kameoka J. MEASUREMENT of Protein 53 Diffusion Coefficient in Live HeLa Cells Using Raster Image Correlation Spectroscopy (RICS). J Biomater Nanobiotechnol. 2010 Oct; 1(1):31-36. PMID: 21804949; PMCID: PMC3146256.
      Citations: 4     
    413. Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. Analyst. 2010 Nov; 135(11):2907-12. PMID: 20877860; PMCID: PMC3001224.
      Citations: 1     Fields:    Translation:HumansCells
    414. Luyimbazi D, Akcakanat A, McAuliffe PF, Zhang L, Singh G, Gonzalez-Angulo AM, Chen H, Do KA, Zheng Y, Hung MC, Mills GB, Meric-Bernstam F. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol Cancer Ther. 2010 Oct; 9(10):2770-84. PMID: 20876744; PMCID: PMC2965451.
      Citations: 33     Fields:    Translation:HumansCells
    415. Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natschke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K, Hung MC, Lee EY, Lee KH. Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent. J Nat Prod. 2010 Sep 24; 73(9):1553-8. PMID: 20738103; PMCID: PMC2954497.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    416. Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D. Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. 2011 Jan 27; 30(4):457-70. PMID: 20856200; PMCID: PMC3010301.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    417. Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Res. 2010 Oct 01; 70(19):7684-9. PMID: 20841468; PMCID: PMC2948588.
      Citations: 9     Fields:    Translation:AnimalsCells
    418. Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, Hung MC. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16125-30. PMID: 20802156; PMCID: PMC2941329.
      Citations: 53     Fields:    Translation:HumansCells
    419. Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung MC, Lopez-Berestein G, Sood AK. Regulation of tumor angiogenesis by EZH2. Cancer Cell. 2010 Aug 09; 18(2):185-97. PMID: 20708159; PMCID: PMC2923653.
      Citations: 201     Fields:    Translation:AnimalsCells
    420. Yamaguchi H, Chen CT, Chou CK, Pal A, Bornmann W, Hortobagyi GN, Hung MC. Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation. Oncogene. 2010 Oct 14; 29(41):5619-29. PMID: 20676141; PMCID: PMC2955174.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    421. Wang YN, Wang H, Yamaguchi H, Lee HJ, Lee HH, Hung MC. COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):498-504. PMID: 20674546; PMCID: PMC2935258.
      Citations: 64     Fields:    Translation:HumansCells
    422. Su JL, Chen PB, Chen YH, Chen SC, Chang YW, Jan YH, Cheng X, Hsiao M, Hung MC. Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Res. 2010 Jun 15; 70(12):5096-108. PMID: 20501832; PMCID: PMC2891368.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    423. Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab Chip. 2010 Jul 21; 10(14):1793-8. PMID: 20498894; PMCID: PMC2919816.
      Citations: 4     Fields:    
    424. Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, Tang P. The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines. Breast Cancer (Auckl). 2010 May 20; 4:35-41. PMID: 20697531; PMCID: PMC2914277.
      Citations: 312     
    425. Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Res. 2010 Jun 01; 70(11):4709-18. PMID: 20484037; PMCID: PMC2895805.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    426. Wang YN, Yamaguchi H, Hsu JM, Hung MC. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene. 2010 Jul 15; 29(28):3997-4006. PMID: 20473332; PMCID: PMC2904849.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    427. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15; 16(12):3171-81. PMID: 20423983; PMCID: PMC2930838.
      Citations: 63     Fields:    Translation:HumansCells
    428. Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J, Torres K, Langley RR, Lazar AJ, Hung MC, Lev D. Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One. 2010 Apr 16; 5(4):e10105. PMID: 20419128; PMCID: PMC2855704.
      Citations: 99     Fields:    Translation:AnimalsCells
    429. Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat Cell Biol. 2010 May; 12(5):457-67. PMID: 20383141; PMCID: PMC3855841.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    430. Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol. 2010 May; 24(5):993-1006. PMID: 20351197; PMCID: PMC2870935.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    431. Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, Hung MC, Lee EY, Lee KH. Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. J Med Chem. 2010 Mar 11; 53(5):2299-308. PMID: 20148565; PMCID: PMC2849726.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    432. Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res. 2010 Mar 15; 70(6):2424-34. PMID: 20215498; PMCID: PMC2840060.
      Citations: 40     Fields:    Translation:HumansCells
    433. Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, Xing G, Zhao Y, Lin CH, Tsai SF, Fidler IJ, Hung MC. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal. 2010 Feb 09; 3(108):ra9. PMID: 20145209; PMCID: PMC2874891.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    434. Liao Y, Hung MC. Physiological regulation of Akt activity and stability. Am J Transl Res. 2010 Jan 01; 2(1):19-42. PMID: 20182580; PMCID: PMC2826820.
      Citations: 178     
    435. Kuo HP, Hung MC. Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? Am J Transl Res. 2010 Jan 01; 2(1):56-64. PMID: 20182582; PMCID: PMC2826822.
      Citations: 13     
    436. Esteva FJ, Yu D, Hung MC, Hortobagyi GN. Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat Rev Clin Oncol. 2010 Feb; 7(2):98-107. PMID: 20027191.
      Citations: 69     Fields:    Translation:Humans
    437. Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH. Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. Bioorg Med Chem. 2010 Jan 15; 18(2):803-8. PMID: 20034799; PMCID: PMC2821697.
      Citations: 5     Fields:    Translation:HumansCells
    438. Andre F, Xia W, Conforti R, Wei Y, Boulet T, Tomasic G, Spielmann M, Zoubir M, Berrada N, Arriagada R, Hortobagyi GN, Hung MC, Pusztai L, Delaloge S, Michiels S, Cristofanilli M. CXCR4 expression in early breast cancer and risk of distant recurrence. Oncologist. 2009 Dec; 14(12):1182-8. PMID: 19939894.
      Citations: 31     Fields:    Translation:Humans
    439. Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Mol Carcinog. 2009 Nov; 48(11):1048-58. PMID: 19526459; PMCID: PMC2783450.
      Citations: 13     Fields:    Translation:HumansCells
    440. Wang SC, Hung MC. Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors. Clin Cancer Res. 2009 Nov 01; 15(21):6484-9. PMID: 19861462; PMCID: PMC5537741.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    441. Zhang D, LaFortune TA, Krishnamurthy S, Esteva FJ, Cristofanilli M, Liu P, Lucci A, Singh B, Hung MC, Hortobagyi GN, Ueno NT. Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer. Clin Cancer Res. 2009 Nov 01; 15(21):6639-48. PMID: 19825949; PMCID: PMC2783487.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    442. Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 09; 36(1):131-40. PMID: 19818716; PMCID: PMC2770835.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    443. Kuo HP, Lee DF, Xia W, Wei Y, Hung MC. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochem Biophys Res Commun. 2009 Nov 27; 389(4):640-4. PMID: 19766100; PMCID: PMC2762003.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    444. Lu J, Guo H, Treekitkarnmongkol W, Li P, Zhang J, Shi B, Ling C, Zhou X, Chen T, Chiao PJ, Feng X, Seewaldt VL, Muller WJ, Sahin A, Hung MC, Yu D. 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell. 2009 Sep 08; 16(3):195-207. PMID: 19732720; PMCID: PMC2754239.
      Citations: 106     Fields:    Translation:HumansCells
    445. Jiralerspong S, Gonzalez-Angulo AM, Hung MC. Expanding the arsenal: metformin for the treatment of triple-negative breast cancer? Cell Cycle. 2009 Sep 01; 8(17):2681. PMID: 19717981.
      Citations: 10     Fields:    Translation:HumansCells
    446. Lee WH, Hung MC, Iczkowski KA, Languino LR, Dubinett SM, Wang D. The launch of the american journal of translational research. Am J Transl Res. 2009 Sep 01; 1(1):i. PMID: 19966932; PMCID: PMC2776285.
      Citations: 1     
    447. Kuo HP, Lee DF, Xia W, Lai CC, Li LY, Hung MC. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. Biochem Biophys Res Commun. 2009 Nov 06; 389(1):156-61. PMID: 19716809; PMCID: PMC2753275.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    448. Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, Petersson F, Price JE, Schroit A, Prieto VG, Hung MC, Bar-Eli M. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem. 2009 Oct 16; 284(42):28845-55. PMID: 19703903; PMCID: PMC2781430.
      Citations: 45     Fields:    Translation:HumansCells
    449. Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC, Hung MC. A novel hTERT promoter-driven E1A therapeutic for ovarian cancer. Mol Cancer Ther. 2009 Aug; 8(8):2375-82. PMID: 19671744; PMCID: PMC2759534.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    450. Sun HL, Tsai AC, Pan SL, Ding Q, Yamaguchi H, Lin CN, Hung MC, Teng CM. EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation. Clin Cancer Res. 2009 Aug 01; 15(15):4904-14. PMID: 19622586.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    451. Xia W, Wei Y, Du Y, Liu J, Chang B, Yu YL, Huo LF, Miller S, Hung MC. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog. 2009 Jul; 48(7):610-7. PMID: 19058255; PMCID: PMC2718429.
      Citations: 85     Fields:    Translation:HumansCells
    452. Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, Zhang F, Yu S, Stephens LC, Cui X, Murrow G, Coombes K, Muller W, Hung MC, Perou CM, Lee AV, Fang X, Mills GB. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell. 2009 Jun 02; 15(6):539-50. PMID: 19477432; PMCID: PMC4157573.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    453. Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, Hsu L, Hung MC, Hortobagyi GN, Gonzalez-Angulo AM. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol. 2009 Jul 10; 27(20):3297-302. PMID: 19487376; PMCID: PMC2736070.
      Citations: 351     Fields:    Translation:Humans
    454. Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 2009 Jul 02; 28(26):2436-45. PMID: 19448664; PMCID: PMC2748248.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    455. Chen G, Izzo J, Demizu Y, Wang F, Guha S, Wu X, Hung MC, Ajani JA, Huang P. Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol. Antioxid Redox Signal. 2009 May; 11(5):1083-95. PMID: 19187006; PMCID: PMC2842128.
      Citations: 14     Fields:    Translation:HumansCells
    456. Cheng X, Hung MC. Regulation of breast cancer metastasis by atypical chemokine receptors. Clin Cancer Res. 2009 May 01; 15(9):2951-3. PMID: 19383808.
      Citations: 1     Fields:    Translation:HumansAnimals
    457. Hawthorne VS, Huang WC, Neal CL, Tseng LM, Hung MC, Yu D. ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Mol Cancer Res. 2009 Apr; 7(4):592-600. PMID: 19372587; PMCID: PMC2689096.
      Citations: 29     Fields:    Translation:HumansCells
    458. Neal CL, Yao J, Yang W, Zhou X, Nguyen NT, Lu J, Danes CG, Guo H, Lan KH, Ensor J, Hittelman W, Hung MC, Yu D. 14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Res. 2009 Apr 15; 69(8):3425-32. PMID: 19318578; PMCID: PMC2671640.
      Citations: 94     Fields:    Translation:HumansCells
    459. Hsu SC, Miller SA, Wang Y, Hung MC. Nuclear EGFR is required for cisplatin resistance and DNA repair. Am J Transl Res. 2009 Mar 08; 1(3):249-58. PMID: 19956435; PMCID: PMC2776325.
      Citations: 53     
    460. Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, Bhalla KN, Monteiro A, Liu X, Hung MC, Wang HG. p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem. 2009 Apr 24; 284(17):11171-83. PMID: 19265193; PMCID: PMC2670122.
      Citations: 66     Fields:    Translation:HumansCells
    461. Huang WC, Hung MC. Induction of Akt activity by chemotherapy confers acquired resistance. J Formos Med Assoc. 2009 Mar; 108(3):180-94. PMID: 19293033.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    462. Hung MC, Mills GB, Yu D. Oxygen sensor boosts growth factor signaling. Nat Med. 2009 Mar; 15(3):246-7. PMID: 19265822.
      Citations: 3     Fields:    Translation:HumansCells
    463. Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res. 2009 Feb 15; 69(4):1343-9. PMID: 19190323; PMCID: PMC2990400.
      Citations: 73     Fields:    Translation:HumansCells
    464. Yang JY, Hung MC. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clin Cancer Res. 2009 Feb 01; 15(3):752-7. PMID: 19188143; PMCID: PMC2676228.
      Citations: 113     Fields:    Translation:HumansCells
    465. Hildebrandt MA, Yang H, Hung MC, Izzo JG, Huang M, Lin J, Ajani JA, Wu X. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. J Clin Oncol. 2009 Feb 20; 27(6):857-71. PMID: 19164214; PMCID: PMC2738430.
      Citations: 80     Fields:    Translation:HumansCells
    466. Lee DF, Kuo HP, Chen CT, Wei Y, Chou CK, Hung JY, Yen CJ, Hung MC. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. Int J Mol Med. 2008 Nov; 22(5):633-8. PMID: 18949383; PMCID: PMC2586899.
      Citations: 27     Fields:    Translation:AnimalsCells
    467. Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A, Hung MC, Eirew P, Eaves CJ, Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Res. 2008 Nov 01; 68(21):8661-6. PMID: 18974106.
      Citations: 49     Fields:    Translation:AnimalsCells
    468. Wang RH, Zheng Y, Kim HS, Xu X, Cao L, Luhasen T, Lee MH, Xiao C, Vassilopoulos A, Chen W, Gardner K, Man YG, Hung MC, Finkel T, Deng CX. Interplay among BRCA1, SIRT1, and Survivin during BRCA1-associated tumorigenesis. Mol Cell. 2008 Oct 10; 32(1):11-20. PMID: 18851829; PMCID: PMC2577018.
      Citations: 171     Fields:    Translation:HumansAnimalsCells
    469. Yamaguchi H, Ding Y, Lee JF, Zhang M, Pal A, Bornmann W, Yan DH, Hung MC. Interferon-inducible protein IFIXalpha inhibits cell invasion by upregulating the metastasis suppressor maspin. Mol Carcinog. 2008 Oct; 47(10):739-43. PMID: 18247378; PMCID: PMC2596649.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    470. Lee DF, Hung MC. Advances in targeting IKK and IKK-related kinases for cancer therapy. Clin Cancer Res. 2008 Sep 15; 14(18):5656-62. PMID: 18794072; PMCID: PMC2613770.
      Citations: 56     Fields:    Translation:HumansCells
    471. Wei Y, Xia W, Zhang Z, Liu J, Wang H, Adsay NV, Albarracin C, Yu D, Abbruzzese JL, Mills GB, Bast RC, Hortobagyi GN, Hung MC. Loss of trimethylation at lysine 27 of histone H3 is a predictor of poor outcome in breast, ovarian, and pancreatic cancers. Mol Carcinog. 2008 Sep; 47(9):701-6. PMID: 18176935; PMCID: PMC2580832.
      Citations: 119     Fields:    Translation:Humans
    472. Stemke-Hale K, Gonzalez-Angulo AM, Lluch A, Neve RM, Kuo WL, Davies M, Carey M, Hu Z, Guan Y, Sahin A, Symmans WF, Pusztai L, Nolden LK, Horlings H, Berns K, Hung MC, van de Vijver MJ, Valero V, Gray JW, Mills GB, Hennessy BT, Bernards R. An integrative genomic and proteomic analysis of PIK3CA, PTEN, and AKT mutations in breast cancer. Cancer Res. 2008 Aug 01; 68(15):6084-91. PMID: 18676830; PMCID: PMC2680495.
      Citations: 498     Fields:    Translation:Humans
    473. Ding Q, Huo L, Yang JY, Xia W, Wei Y, Liao Y, Chang CJ, Yang Y, Lai CC, Lee DF, Yen CJ, Chen YJ, Hsu JM, Kuo HP, Lin CY, Tsai FJ, Li LY, Tsai CH, Hung MC. Down-regulation of myeloid cell leukemia-1 through inhibiting Erk/Pin 1 pathway by sorafenib facilitates chemosensitization in breast cancer. Cancer Res. 2008 Aug 01; 68(15):6109-17. PMID: 18676833; PMCID: PMC2676572.
      Citations: 83     Fields:    Translation:HumansCells
    474. Su JL, Chen PS, Chien MH, Chen PB, Chen YH, Lai CC, Hung MC, Kuo ML. Further evidence for expression and function of the VEGF-C/VEGFR-3 axis in cancer cells. Cancer Cell. 2008 Jun; 13(6):557-60. PMID: 18538739.
      Citations: 18     Fields:    Translation:HumansCells
    475. Weihua Z, Tsan R, Huang WC, Wu Q, Chiu CH, Fidler IJ, Hung MC. Survival of cancer cells is maintained by EGFR independent of its kinase activity. Cancer Cell. 2008 May; 13(5):385-93. PMID: 18455122; PMCID: PMC2413063.
      Citations: 214     Fields:    Translation:Humans
    476. Yen CJ, Izzo JG, Lee DF, Guha S, Wei Y, Wu TT, Chen CT, Kuo HP, Hsu JM, Sun HL, Chou CK, Buttar NS, Wang KK, Huang P, Ajani J, Hung MC. Bile acid exposure up-regulates tuberous sclerosis complex 1/mammalian target of rapamycin pathway in Barrett's-associated esophageal adenocarcinoma. Cancer Res. 2008 Apr 15; 68(8):2632-40. PMID: 18413730; PMCID: PMC2377413.
      Citations: 29     Fields:    Translation:Humans
    477. Yang JY, Zong CS, Xia W, Yamaguchi H, Ding Q, Xie X, Lang JY, Lai CC, Chang CJ, Huang WC, Huang H, Kuo HP, Lee DF, Li LY, Lien HC, Cheng X, Chang KJ, Hsiao CD, Tsai FJ, Tsai CH, Sahin AA, Muller WJ, Mills GB, Yu D, Hortobagyi GN, Hung MC. ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation. Nat Cell Biol. 2008 Feb; 10(2):138-48. PMID: 18204439; PMCID: PMC2376808.
      Citations: 324     Fields:    Translation:HumansAnimalsCells
    478. Kang T, Wei Y, Honaker Y, Yamaguchi H, Appella E, Hung MC, Piwnica-Worms H. GSK-3 beta targets Cdc25A for ubiquitin-mediated proteolysis, and GSK-3 beta inactivation correlates with Cdc25A overproduction in human cancers. Cancer Cell. 2008 Jan; 13(1):36-47. PMID: 18167338; PMCID: PMC2276649.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    479. Cheng X, Hung MC. Breast cancer brain metastases. Cancer Metastasis Rev. 2007 Dec; 26(3-4):635-43. PMID: 17717635.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    480. Tsai KL, Sun YJ, Huang CY, Yang JY, Hung MC, Hsiao CD. Crystal structure of the human FOXO3a-DBD/DNA complex suggests the effects of post-translational modification. Nucleic Acids Res. 2007; 35(20):6984-94. PMID: 17940099; PMCID: PMC2175300.
      Citations: 84     Fields:    Translation:HumansCells
    481. Lo HW, Hsu SC, Xia W, Cao X, Shih JY, Wei Y, Abbruzzese JL, Hortobagyi GN, Hung MC. Epidermal growth factor receptor cooperates with signal transducer and activator of transcription 3 to induce epithelial-mesenchymal transition in cancer cells via up-regulation of TWIST gene expression. Cancer Res. 2007 Oct 01; 67(19):9066-76. PMID: 17909010; PMCID: PMC2570961.
      Citations: 286     Fields:    Translation:HumansAnimalsCells
    482. Lee DF, Hung MC. All roads lead to mTOR: integrating inflammation and tumor angiogenesis. Cell Cycle. 2007 Dec 15; 6(24):3011-4. PMID: 18073529.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    483. Lee DF, Kuo HP, Chen CT, Hsu JM, Chou CK, Wei Y, Sun HL, Li LY, Ping B, Huang WC, He X, Hung JY, Lai CC, Ding Q, Su JL, Yang JY, Sahin AA, Hortobagyi GN, Tsai FJ, Tsai CH, Hung MC. IKK beta suppression of TSC1 links inflammation and tumor angiogenesis via the mTOR pathway. Cell. 2007 Aug 10; 130(3):440-55. PMID: 17693255.
      Citations: 305     Fields:    Translation:HumansAnimalsCells
    484. Akcakanat A, Singh G, Hung MC, Meric-Bernstam F. Rapamycin regulates the phosphorylation of rictor. Biochem Biophys Res Commun. 2007 Oct 19; 362(2):330-3. PMID: 17707343; PMCID: PMC2040311.
      Citations: 31     Fields:    Translation:HumansCells
    485. Brugge J, Hung MC, Mills GB. A new mutational AKTivation in the PI3K pathway. Cancer Cell. 2007 Aug; 12(2):104-7. PMID: 17692802.
      Citations: 120     Fields:    Translation:HumansAnimalsCells
    486. Wang X, Zheng M, Liu G, Xia W, McKeown-Longo PJ, Hung MC, Zhao J. Kr?ppel-like factor 8 induces epithelial to mesenchymal transition and epithelial cell invasion. Cancer Res. 2007 Aug 01; 67(15):7184-93. PMID: 17671186.
      Citations: 91     Fields:    Translation:HumansCells
    487. Nakagawa-Goto K, Yamada K, Nakamura S, Chen TH, Chiang PC, Bastow KF, Wang SC, Spohn B, Hung MC, Lee FY, Lee FC, Lee KH. Antitumor agents. 258. Syntheses and evaluation of dietary antioxidant--taxoid conjugates as novel cytotoxic agents. Bioorg Med Chem Lett. 2007 Sep 15; 17(18):5204-9. PMID: 17643301; PMCID: PMC2329582.
      Citations: 14     Fields:    Translation:HumansCells
    488. Lien HC, Hsiao YH, Lin YS, Yao YT, Juan HF, Kuo WH, Hung MC, Chang KJ, Hsieh FJ. Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial-mesenchymal transition. Oncogene. 2007 Dec 13; 26(57):7859-71. PMID: 17603561.
      Citations: 84     Fields:    Translation:HumansCells
    489. Xie X, Xia W, Li Z, Kuo HP, Liu Y, Li Z, Ding Q, Zhang S, Spohn B, Yang Y, Wei Y, Lang JY, Evans DB, Chiao PJ, Abbruzzese JL, Hung MC. Targeted expression of BikDD eradicates pancreatic tumors in noninvasive imaging models. Cancer Cell. 2007 Jul; 12(1):52-65. PMID: 17613436.
      Citations: 40     Fields:    Translation:Animals
    490. Izzo JG, Malhotra U, Wu TT, Luthra R, Correa AM, Swisher SG, Hofstetter W, Chao KS, Hung MC, Ajani JA. Clinical biology of esophageal adenocarcinoma after surgery is influenced by nuclear factor-kappaB expression. Cancer Epidemiol Biomarkers Prev. 2007 Jun; 16(6):1200-5. PMID: 17548685.
      Citations: 9     Fields:    Translation:Humans
    491. Uwagawa T, Li Z, Chang Z, Xia Q, Peng B, Sclabas GM, Ishiyama S, Hung MC, Evans DB, Abbruzzese JL, Chiao PJ. Mechanisms of synthetic serine protease inhibitor (FUT-175)-mediated cell death. Cancer. 2007 May 15; 109(10):2142-53. PMID: 17410536.
      Citations: 15     Fields:    Translation:HumansCells
    492. Ding Q, He X, Xia W, Hsu JM, Chen CT, Li LY, Lee DF, Yang JY, Xie X, Liu JC, Hung MC. Myeloid cell leukemia-1 inversely correlates with glycogen synthase kinase-3beta activity and associates with poor prognosis in human breast cancer. Cancer Res. 2007 May 15; 67(10):4564-71. PMID: 17495324.
      Citations: 104     Fields:    Translation:HumansCells
    493. Casimiro M, Rodriguez O, Pootrakul L, Aventian M, Lushina N, Cromelin C, Ferzli G, Johnson K, Fricke S, Diba F, Kallakury B, Ohanyerenwa C, Chen M, Ostrowski M, Hung MC, Rabbani SA, Datar R, Cote R, Pestell R, Albanese C. ErbB-2 induces the cyclin D1 gene in prostate epithelial cells in vitro and in vivo. Cancer Res. 2007 May 01; 67(9):4364-72. PMID: 17483350.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    494. Huang WC, Ju TK, Hung MC, Chen CC. Phosphorylation of CBP by IKKalpha promotes cell growth by switching the binding preference of CBP from p53 to NF-kappaB. Mol Cell. 2007 Apr 13; 26(1):75-87. PMID: 17434128; PMCID: PMC2312502.
      Citations: 119     Fields:    Translation:HumansCells
    495. Izzo JG, Luthra R, Wu TT, Correa AM, Luthra M, Anandasabapathy S, Chao KS, Hung MC, Aggarwal B, Hittelman WN, Ajani JA. Molecular mechanisms in Barrett's metaplasia and its progression. Semin Oncol. 2007 Apr; 34(2 Suppl 1):S2-6. PMID: 17449347.
      Citations: 9     Fields:    Translation:HumansCells
    496. Ding Q, He X, Hsu JM, Xia W, Chen CT, Li LY, Lee DF, Liu JC, Zhong Q, Wang X, Hung MC. Degradation of Mcl-1 by beta-TrCP mediates glycogen synthase kinase 3-induced tumor suppression and chemosensitization. Mol Cell Biol. 2007 Jun; 27(11):4006-17. PMID: 17387146; PMCID: PMC1900029.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    497. Hsu SC, Hung MC. Characterization of a novel tripartite nuclear localization sequence in the EGFR family. J Biol Chem. 2007 Apr 06; 282(14):10432-40. PMID: 17283074.
      Citations: 118     Fields:    Translation:HumansCells
    498. Izzo JG, Luthra R, Sims-Mourtada J, Chao KS, Lee JH, Wu TT, Correa AM, Luthra M, Aggarwal B, Hung MC, Ajani JA. Emerging molecular targets in esophageal cancers. Gastrointest Cancer Res. 2007; 1(4 Suppl 2):S3-6. PMID: 19360144; PMCID: PMC2666833.
      Citations: 5     
    499. Liao Y, Yu D, Hung MC. Novel approaches for chemosensitization of breast cancer cells: the E1A story. Adv Exp Med Biol. 2007; 608:144-69. PMID: 17993239.
      Citations: 15     Fields:    Translation:Humans
    500. Lo HW, Hung MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br J Cancer. 2007; 96 Suppl:R16-20. PMID: 17393580.
      Citations: 12     Fields:    
    501. Wang SC, Nakajima Y, Yu YL, Xia W, Chen CT, Yang CC, McIntush EW, Li LY, Hawke DH, Kobayashi R, Hung MC. Tyrosine phosphorylation controls PCNA function through protein stability. Nat Cell Biol. 2006 Dec; 8(12):1359-68. PMID: 17115032.
      Citations: 158     Fields:    Translation:HumansCells
    502. Meric-Bernstam F, Hung MC. Advances in targeting human epidermal growth factor receptor-2 signaling for cancer therapy. Clin Cancer Res. 2006 Nov 01; 12(21):6326-30. PMID: 17085641.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    503. Ping B, He X, Xia W, Lee DF, Wei Y, Yu D, Mills G, Shi D, Hung MC. Cytoplasmic expression of p21CIP1/WAF1 is correlated with IKKbeta overexpression in human breast cancers. Int J Oncol. 2006 Nov; 29(5):1103-10. PMID: 17016640.
      Citations: 10     Fields:    Translation:HumansCells
    504. Jiang H, Olson MV, Medrano DR, Lee OH, Xu J, Piao Y, Alonso MM, Gomez-Manzano C, Hung MC, Yung WK, Fueyo J. A novel CRM1-dependent nuclear export signal in adenoviral E1A protein regulated by phosphorylation. FASEB J. 2006 Dec; 20(14):2603-5. PMID: 17065226.
      Citations: 7     Fields:    Translation:HumansCells
    505. Yang JY, Zong CS, Xia W, Wei Y, Ali-Seyed M, Li Z, Broglio K, Berry DA, Hung MC. MDM2 promotes cell motility and invasiveness by regulating E-cadherin degradation. Mol Cell Biol. 2006 Oct; 26(19):7269-82. PMID: 16980628; PMCID: PMC1592879.
      Citations: 101     Fields:    Translation:HumansCells
    506. Yu Z, Xia W, Wang HY, Wang SC, Pan Y, Kwong KY, Hortobagyi GN, Hung MC. Antitumor activity of an Ets protein, PEA3, in breast cancer cell lines MDA-MB-361DYT2 and BT474M1. Mol Carcinog. 2006 Sep; 45(9):667-75. PMID: 16652376.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    507. Lo HW, Ali-Seyed M, Wu Y, Bartholomeusz G, Hsu SC, Hung MC. Nuclear-cytoplasmic transport of EGFR involves receptor endocytosis, importin beta1 and CRM1. J Cell Biochem. 2006 Aug 15; 98(6):1570-83. PMID: 16552725.
      Citations: 113     Fields:    Translation:HumansAnimalsCells
    508. Xia WY, Lien HC, Wang SC, Pan Y, Sahin A, Kuo YH, Chang KJ, Zhou X, Wang H, Yu Z, Hortobagyi G, Shi DR, Hung MC. Expression of PEA3 and lack of correlation between PEA3 and HER-2/neu expression in breast cancer. Breast Cancer Res Treat. 2006 Aug; 98(3):295-301. PMID: 16752078.
      Citations: 9     Fields:    Translation:Humans
    509. Nahta R, Yu D, Hung MC, Hortobagyi GN, Esteva FJ. Mechanisms of disease: understanding resistance to HER2-targeted therapy in human breast cancer. Nat Clin Pract Oncol. 2006 May; 3(5):269-80. PMID: 16683005.
      Citations: 355     Fields:    Translation:HumansCells
    510. Day CP, Rau KM, Qiu L, Liu CW, Kuo HP, Xie X, Lopez-Berestein G, Hortobagyi GN, Hung MC. Mutant Bik expression mediated by the enhanced minimal topoisomerase IIalpha promoter selectively suppressed breast tumors in an animal model. Cancer Gene Ther. 2006 Jul; 13(7):706-19. PMID: 16514421.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    511. Su JL, Yang PC, Shih JY, Yang CY, Wei LH, Hsieh CY, Chou CH, Jeng YM, Wang MY, Chang KJ, Hung MC, Kuo ML. The VEGF-C/Flt-4 axis promotes invasion and metastasis of cancer cells. Cancer Cell. 2006 Mar; 9(3):209-23. PMID: 16530705.
      Citations: 126     Fields:    Translation:HumansAnimals
    512. Li M, Wang Y, Hung MC, Kannan P. Inefficient proteasomal-degradation pathway stabilizes AP-2alpha and activates HER-2/neu gene in breast cancer. Int J Cancer. 2006 Feb 15; 118(4):802-11. PMID: 16108032.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    513. Bartholomeusz G, Wu Y, Ali Seyed M, Xia W, Kwong KY, Hortobagyi G, Hung MC. Nuclear translocation of the pro-apoptotic Bcl-2 family member Bok induces apoptosis. Mol Carcinog. 2006 Feb; 45(2):73-83. PMID: 16302269.
      Citations: 21     Fields:    Translation:HumansCells
    514. Konopleva M, Zhang W, Shi YX, McQueen T, Tsao T, Abdelrahim M, Munsell MF, Johansen M, Yu D, Madden T, Safe SH, Hung MC, Andreeff M. Synthetic triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid induces growth arrest in HER2-overexpressing breast cancer cells. Mol Cancer Ther. 2006 Feb; 5(2):317-28. PMID: 16505105.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    515. Lo HW, Hsu SC, Hung MC. EGFR signaling pathway in breast cancers: from traditional signal transduction to direct nuclear translocalization. Breast Cancer Res Treat. 2006 Feb; 95(3):211-8. PMID: 16261406.
      Citations: 85     Fields:    Translation:HumansCells
    516. Lo HW, Hung MC. Nuclear EGFR signalling network in cancers: linking EGFR pathway to cell cycle progression, nitric oxide pathway and patient survival. Br J Cancer. 2006 Jan 30; 94(2):184-8. PMID: 16434982; PMCID: PMC2361115.
      Citations: 121     Fields:    Translation:HumansAnimalsCells
    517. Chou CK, Hung JY, Liu JC, Chen CT, Hung MC. An attenuated Salmonella oral DNA vaccine prevents the growth of hepatocellular carcinoma and colon cancer that express alpha-fetoprotein. Cancer Gene Ther. 2006 Aug; 13(8):746-52. PMID: 16410824.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    518. Ou-Yang F, Lan KL, Chen CT, Liu JC, Weng CL, Chou CK, Xie X, Hung JY, Wei Y, Hortobagyi GN, Hung MC. Endostatin-cytosine deaminase fusion protein suppresses tumor growth by targeting neovascular endothelial cells. Cancer Res. 2006 Jan 01; 66(1):378-84. PMID: 16397252.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    519. Hanada N, Lo HW, Day CP, Pan Y, Nakajima Y, Hung MC. Co-regulation of B-Myb expression by E2F1 and EGF receptor. Mol Carcinog. 2006 Jan; 45(1):10-7. PMID: 16299810.
      Citations: 82     Fields:    Translation:HumansAnimalsCells
    520. Chen IF, Ou-Yang F, Hung JY, Liu JC, Wang H, Wang SC, Hou MF, Hortobagyi GN, Hung MC. AIM2 suppresses human breast cancer cell proliferation in vitro and mammary tumor growth in a mouse model. Mol Cancer Ther. 2006 Jan; 5(1):1-7. PMID: 16432157.
      Citations: 51     Fields:    Translation:HumansAnimalsCells
    521. Mejia R, Olivero O, Rivera-Goba M, Anders A, Caban C, Leon-Monzon M, Marquez E. Asian scientists and the "glass ceiling". Science. 2005 Dec 16; 310(5755):1767-8. PMID: 16363026.
      Citations:    Fields:    Translation:Humans
    522. Hung MC, Fong K, Li JK. Asian scientists and the "glass ceiling". Science. 2005 Dec 16; 310(5755):1767-8. PMID: 16357243.
      Citations:    Fields:    Translation:Humans
    523. Giri DK, Ali-Seyed M, Li LY, Lee DF, Ling P, Bartholomeusz G, Wang SC, Hung MC. Endosomal transport of ErbB-2: mechanism for nuclear entry of the cell surface receptor. Mol Cell Biol. 2005 Dec; 25(24):11005-18. PMID: 16314522; PMCID: PMC1316946.
      Citations: 109     Fields:    Translation:HumansCells
    524. Coombes KR, Tsavachidis S, Morris JS, Baggerly KA, Hung MC, Kuerer HM. Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform. Proteomics. 2005 Nov; 5(16):4107-17. PMID: 16254928.
      Citations: 74     Fields:    Translation:Humans
    525. Wang SC, Hung MC. Cytoplasmic/nuclear shuttling and tumor progression. Ann N Y Acad Sci. 2005 Nov; 1059:11-5. PMID: 16382038.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    526. Cha TL, Zhou BP, Xia W, Wu Y, Yang CC, Chen CT, Ping B, Otte AP, Hung MC. Akt-mediated phosphorylation of EZH2 suppresses methylation of lysine 27 in histone H3. Science. 2005 Oct 14; 310(5746):306-10. PMID: 16224021.
      Citations: 275     Fields:    Translation:HumansAnimalsCells
    527. Bisanz K, Yu J, Edlund M, Spohn B, Hung MC, Chung LW, Hsieh CL. Targeting ECM-integrin interaction with liposome-encapsulated small interfering RNAs inhibits the growth of human prostate cancer in a bone xenograft imaging model. Mol Ther. 2005 Oct; 12(4):634-43. PMID: 16039164.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    528. Bartholomeusz C, Itamochi H, Yuan LX, Esteva FJ, Wood CG, Terakawa N, Hung MC, Ueno NT. Bcl-2 antisense oligonucleotide overcomes resistance to E1A gene therapy in a low HER2-expressing ovarian cancer xenograft model. Cancer Res. 2005 Sep 15; 65(18):8406-13. PMID: 16166319.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    529. Ding Q, Xia W, Liu JC, Yang JY, Lee DF, Xia J, Bartholomeusz G, Li Y, Pan Y, Li Z, Bargou RC, Qin J, Lai CC, Tsai FJ, Tsai CH, Hung MC. Erk associates with and primes GSK-3beta for its inactivation resulting in upregulation of beta-catenin. Mol Cell. 2005 Jul 22; 19(2):159-70. PMID: 16039586.
      Citations: 259     Fields:    Translation:HumansCells
    530. Zhou BP, Hung MC. Wnt, hedgehog and snail: sister pathways that control by GSK-3beta and beta-Trcp in the regulation of metastasis. Cell Cycle. 2005 Jun; 4(6):772-6. PMID: 15917668.
      Citations: 56     Fields:    Translation:HumansCells
    531. Li Z, Ding Q, Li Y, Miller SA, Abbruzzese JL, Hung MC. Suppression of pancreatic tumor progression by systemic delivery of a pancreatic-cancer-specific promoter driven Bik mutant. Cancer Lett. 2006 May 08; 236(1):58-63. PMID: 15953675.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    532. Lo HW, Hsu SC, Ali-Seyed M, Gunduz M, Xia W, Wei Y, Bartholomeusz G, Shih JY, Hung MC. Nuclear interaction of EGFR and STAT3 in the activation of the iNOS/NO pathway. Cancer Cell. 2005 Jun; 7(6):575-89. PMID: 15950906.
      Citations: 239     Fields:    Translation:HumansAnimalsCells
    533. Hung MC. When all colonies are blue. Cancer Biol Ther. 2005 May; 4(5):612-4. PMID: 15970681.
      Citations:    Fields:    Translation:AnimalsCells
    534. Li YM, Zhou BP, Deng J, Pan Y, Hay N, Hung MC. A hypoxia-independent hypoxia-inducible factor-1 activation pathway induced by phosphatidylinositol-3 kinase/Akt in HER2 overexpressing cells. Cancer Res. 2005 Apr 15; 65(8):3257-63. PMID: 15833858.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    535. Kumar R, Hung MC. Signaling intricacies take center stage in cancer cells. Cancer Res. 2005 Apr 01; 65(7):2511-5. PMID: 15805240.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    536. Shao R, Lee DF, Wen Y, Ding Y, Xia W, Ping B, Yagita H, Spohn B, Hung MC. E1A sensitizes cancer cells to TRAIL-induced apoptosis through enhancement of caspase activation. Mol Cancer Res. 2005 Apr; 3(4):219-26. PMID: 15831675.
      Citations: 5     Fields:    Translation:HumansCells
    537. Cha TL, Qiu L, Chen CT, Wen Y, Hung MC. Emodin down-regulates androgen receptor and inhibits prostate cancer cell growth. Cancer Res. 2005 Mar 15; 65(6):2287-95. PMID: 15781642.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    538. Dong J, Peng J, Zhang H, Mondesire WH, Jian W, Mills GB, Hung MC, Meric-Bernstam F. Role of glycogen synthase kinase 3beta in rapamycin-mediated cell cycle regulation and chemosensitivity. Cancer Res. 2005 Mar 01; 65(5):1961-72. PMID: 15753396.
      Citations: 40     Fields:    Translation:HumansCells
    539. Hu MC, Hung MC. Role of IkappaB kinase in tumorigenesis. Future Oncol. 2005 Feb; 1(1):67-78. PMID: 16555977.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    540. Lo HW, Xia W, Wei Y, Ali-Seyed M, Huang SF, Hung MC. Novel prognostic value of nuclear epidermal growth factor receptor in breast cancer. Cancer Res. 2005 Jan 01; 65(1):338-48. PMID: 15665312.
      Citations: 125     Fields:    Translation:HumansCells
    541. Lo HW, Day CP, Hung MC. Cancer-specific gene therapy. Adv Genet. 2005; 54:235-55. PMID: 16096014.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    542. Pawlik TM, Fritsche H, Coombes KR, Xiao L, Krishnamurthy S, Hunt KK, Pusztai L, Chen JN, Clarke CH, Arun B, Hung MC, Kuerer HM. Significant differences in nipple aspirate fluid protein expression between healthy women and those with breast cancer demonstrated by time-of-flight mass spectrometry. Breast Cancer Res Treat. 2005 Jan; 89(2):149-57. PMID: 15692757.
      Citations: 24     Fields:    Translation:HumansCTClinical Trials
    543. Li Z, Day CP, Yang JY, Tsai WB, Lozano G, Shih HM, Hung MC. Adenoviral E1A targets Mdm4 to stabilize tumor suppressor p53. Cancer Res. 2004 Dec 15; 64(24):9080-5. PMID: 15604276.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    544. Wang SC, Hung MC. Finding the bEST routes to cancer. Cancer Biol Ther. 2004 Nov; 3(11):1090-1. PMID: 15640624.
      Citations:    Fields:    Translation:HumansCells
    545. Chen JS, Liu JC, Shen L, Rau KM, Kuo HP, Li YM, Shi D, Lee YC, Chang KJ, Hung MC. Cancer-specific activation of the survivin promoter and its potential use in gene therapy. Cancer Gene Ther. 2004 Nov; 11(11):740-7. PMID: 15359286.
      Citations: 38     Fields:    Translation:HumansCells
    546. Li YM, Pan Y, Wei Y, Cheng X, Zhou BP, Tan M, Zhou X, Xia W, Hortobagyi GN, Yu D, Hung MC. Upregulation of CXCR4 is essential for HER2-mediated tumor metastasis. Cancer Cell. 2004 Nov; 6(5):459-69. PMID: 15542430.
      Citations: 214     Fields:    Translation:HumansAnimalsCells
    547. Kuerer HM, Coombes KR, Chen JN, Xiao L, Clarke C, Fritsche H, Krishnamurthy S, Marcy S, Hung MC, Hunt KK. Association between ductal fluid proteomic expression profiles and the presence of lymph node metastases in women with breast cancer. Surgery. 2004 Nov; 136(5):1061-9. PMID: 15523402.
      Citations: 4     Fields:    Translation:Humans
    548. Mondesire WH, Jian W, Zhang H, Ensor J, Hung MC, Mills GB, Meric-Bernstam F. Targeting mammalian target of rapamycin synergistically enhances chemotherapy-induced cytotoxicity in breast cancer cells. Clin Cancer Res. 2004 Oct 15; 10(20):7031-42. PMID: 15501983.
      Citations: 115     Fields:    Translation:HumansCells
    549. Zhou BP, Deng J, Xia W, Xu J, Li YM, Gunduz M, Hung MC. Dual regulation of Snail by GSK-3beta-mediated phosphorylation in control of epithelial-mesenchymal transition. Nat Cell Biol. 2004 Oct; 6(10):931-40. PMID: 15448698.
      Citations: 736     Fields:    Translation:HumansCells
    550. Liao Y, Hung MC. A new role of protein phosphatase 2a in adenoviral E1A protein-mediated sensitization to anticancer drug-induced apoptosis in human breast cancer cells. Cancer Res. 2004 Sep 01; 64(17):5938-42. PMID: 15342371.
      Citations: 27     Fields:    Translation:HumansCells
    551. Wang SC, Lien HC, Xia W, Chen IF, Lo HW, Wang Z, Ali-Seyed M, Lee DF, Bartholomeusz G, Ou-Yang F, Giri DK, Hung MC. Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2. Cancer Cell. 2004 Sep; 6(3):251-61. PMID: 15380516.
      Citations: 135     Fields:    Translation:HumansCells
    552. Liao Y, Zou YY, Xia WY, Hung MC. Enhanced paclitaxel cytotoxicity and prolonged animal survival rate by a nonviral-mediated systemic delivery of E1A gene in orthotopic xenograft human breast cancer. Cancer Gene Ther. 2004 Sep; 11(9):594-602. PMID: 15272313.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    553. Nagata Y, Lan KH, Zhou X, Tan M, Esteva FJ, Sahin AA, Klos KS, Li P, Monia BP, Nguyen NT, Hortobagyi GN, Hung MC, Yu D. PTEN activation contributes to tumor inhibition by trastuzumab, and loss of PTEN predicts trastuzumab resistance in patients. Cancer Cell. 2004 Aug; 6(2):117-27. PMID: 15324695.
      Citations: 697     Fields:    Translation:HumansAnimalsCells
    554. Nahta R, Takahashi T, Ueno NT, Hung MC, Esteva FJ. P27(kip1) down-regulation is associated with trastuzumab resistance in breast cancer cells. Cancer Res. 2004 Jun 01; 64(11):3981-6. PMID: 15173011.
      Citations: 110     Fields:    Translation:HumansCells
    555. Xia W, Chen JS, Zhou X, Sun PR, Lee DF, Liao Y, Zhou BP, Hung MC. Phosphorylation/cytoplasmic localization of p21Cip1/WAF1 is associated with HER2/neu overexpression and provides a novel combination predictor for poor prognosis in breast cancer patients. Clin Cancer Res. 2004 Jun 01; 10(11):3815-24. PMID: 15173090.
      Citations: 67     Fields:    Translation:HumansCells
    556. Makino K, Day CP, Wang SC, Li YM, Hung MC. Upregulation of IKKalpha/IKKbeta by integrin-linked kinase is required for HER2/neu-induced NF-kappaB antiapoptotic pathway. Oncogene. 2004 May 06; 23(21):3883-7. PMID: 15021910.
      Citations: 20     Fields:    Translation:AnimalsCells
    557. Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC. IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a. Cell. 2004 Apr 16; 117(2):225-37. PMID: 15084260.
      Citations: 397     Fields:    Translation:HumansAnimalsCells
    558. Nahta R, Hung MC, Esteva FJ. The HER-2-targeting antibodies trastuzumab and pertuzumab synergistically inhibit the survival of breast cancer cells. Cancer Res. 2004 Apr 01; 64(7):2343-6. PMID: 15059883.
      Citations: 211     Fields:    Translation:HumansCells
    559. Yan DH, Wen Y, Su LK, Xia W, Wang SC, Zhang S, Gan L, Lee DF, Spohn B, Frey JA, Hortobagyi GN, Hung MC. A delayed chemically induced tumorigenesis in Brca2 mutant mice. Oncogene. 2004 Mar 11; 23(10):1896-901. PMID: 14981540.
      Citations: 4     Fields:    Translation:AnimalsCells
    560. Lee CM, Lo HW, Shao RP, Wang SC, Xia W, Gershenson DM, Hung MC. Selective activation of ceruloplasmin promoter in ovarian tumors: potential use for gene therapy. Cancer Res. 2004 Mar 01; 64(5):1788-93. PMID: 14996741.
      Citations: 12     Fields:    Translation:HumansCells
    561. Deng J, Xia W, Miller SA, Wen Y, Wang HY, Hung MC. Crossregulation of NF-kappaB by the APC/GSK-3beta/beta-catenin pathway. Mol Carcinog. 2004 Mar; 39(3):139-46. PMID: 14991743.
      Citations: 37     Fields:    Translation:HumansCells
    562. Noh WC, Mondesire WH, Peng J, Jian W, Zhang H, Dong J, Mills GB, Hung MC, Meric-Bernstam F. Determinants of rapamycin sensitivity in breast cancer cells. Clin Cancer Res. 2004 Feb 01; 10(3):1013-23. PMID: 14871980.
      Citations: 114     Fields:    Translation:HumansCells
    563. Royce ME, Xia W, Sahin AA, Katayama H, Johnston DA, Hortobagyi G, Sen S, Hung MC. STK15/Aurora-A expression in primary breast tumors is correlated with nuclear grade but not with prognosis. Cancer. 2004 Jan 01; 100(1):12-9. PMID: 14692019.
      Citations: 20     Fields:    Translation:HumansCells
    564. Yan DH, Spohn B, Hung MC. Delivery of DNA to tumor cells using cationic liposomes. Methods Mol Biol. 2004; 245:125-36. PMID: 14707374.
      Citations: 1     Fields:    Translation:HumansCells
    565. Hoque A, Carter J, Xia W, Hung MC, Sahin AA, Sen S, Lippman SM. Loss of aurora A/STK15/BTAK overexpression correlates with transition of in situ to invasive ductal carcinoma of the breast. Cancer Epidemiol Biomarkers Prev. 2003 Dec; 12(12):1518-22. PMID: 14693746.
      Citations: 28     Fields:    Translation:Humans
    566. Li YM, Wen Y, Zhou BP, Kuo HP, Ding Q, Hung MC. Enhancement of Bik antitumor effect by Bik mutants. Cancer Res. 2003 Nov 15; 63(22):7630-3. PMID: 14633680.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    567. Coombes KR, Fritsche HA, Clarke C, Chen JN, Baggerly KA, Morris JS, Xiao LC, Hung MC, Kuerer HM. Quality control and peak finding for proteomics data collected from nipple aspirate fluid by surface-enhanced laser desorption and ionization. Clin Chem. 2003 Oct; 49(10):1615-23. PMID: 14500586.
      Citations: 33     Fields:    Translation:Humans
    568. Zhou BP, Hung MC. Dysregulation of cellular signaling by HER2/neu in breast cancer. Semin Oncol. 2003 Oct; 30(5 Suppl 16):38-48. PMID: 14613025.
      Citations: 35     Fields:    Translation:HumansCells
    569. Liao Y, Hung MC. Regulation of the activity of p38 mitogen-activated protein kinase by Akt in cancer and adenoviral protein E1A-mediated sensitization to apoptosis. Mol Cell Biol. 2003 Oct; 23(19):6836-48. PMID: 12972603; PMCID: PMC193925.
      Citations: 39     Fields:    Translation:HumansCells
    570. Lee WP, Tai DI, Tsai SL, Yeh CT, Chao Y, Lee SD, Hung MC. Adenovirus type 5 E1A sensitizes hepatocellular carcinoma cells to gemcitabine. Cancer Res. 2003 Oct 01; 63(19):6229-36. PMID: 14559808.
      Citations: 12     Fields:    Translation:HumansCells
    571. Wen Y, Giri D, Yan DH, Spohn B, Zinner RG, Xia W, Thompson TC, Matusik RJ, Hung MC. Prostate-specific antitumor activity by probasin promoter-directed p202 expression. Mol Carcinog. 2003 Jul; 37(3):130-7. PMID: 12884364.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    572. Najafi SM, Li Z, Makino K, Shao R, Hung MC. The adenoviral E1A induces p21WAF1/CIP1 expression in cancer cells. Biochem Biophys Res Commun. 2003 Jun 13; 305(4):1099-104. PMID: 12767945.
      Citations: 5     Fields:    Translation:HumansCells
    573. Chen JS, Lan K, Hung MC. Strategies to target HER2/neu overexpression for cancer therapy. Drug Resist Updat. 2003 Jun; 6(3):129-36. PMID: 12860460.
      Citations: 19     Fields:    Translation:HumansAnimals
    574. Lee CM, Shvartsman H, Deavers MT, Wang SC, Xia W, Schmandt R, Bodurka DC, Atkinson EN, Malpica A, Gershenson DM, Hung MC, Lu KH. beta-catenin nuclear localization is associated with grade in ovarian serous carcinoma. Gynecol Oncol. 2003 Mar; 88(3):363-8. PMID: 12648588.
      Citations: 23     Fields:    Translation:HumansCells
    575. Kwong KY, Zou Y, Day CP, Hung MC. The suppression of colon cancer cell growth in nude mice by targeting beta-catenin/TCF pathway. Oncogene. 2002 Nov 28; 21(54):8340-6. PMID: 12447697.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    576. Ueno NT, Bartholomeusz C, Xia W, Anklesaria P, Bruckheimer EM, Mebel E, Paul R, Li S, Yo GH, Huang L, Hung MC. Systemic gene therapy in human xenograft tumor models by liposomal delivery of the E1A gene. Cancer Res. 2002 Nov 15; 62(22):6712-6. PMID: 12438271.
      Citations: 17     Fields:    Translation:Humans
    577. Lee S, Yang W, Lan KH, Sellappan S, Klos K, Hortobagyi G, Hung MC, Yu D. Enhanced sensitization to taxol-induced apoptosis by herceptin pretreatment in ErbB2-overexpressing breast cancer cells. Cancer Res. 2002 Oct 15; 62(20):5703-10. PMID: 12384528.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    578. Yeh S, Tsai MY, Xu Q, Mu XM, Lardy H, Huang KE, Lin H, Yeh SD, Altuwaijri S, Zhou X, Xing L, Boyce BF, Hung MC, Zhang S, Gan L, Chang C, Hung MC. Generation and characterization of androgen receptor knockout (ARKO) mice: an in vivo model for the study of androgen functions in selective tissues. Proc Natl Acad Sci U S A. 2002 Oct 15; 99(21):13498-503. PMID: 12370412; PMCID: PMC129702.
      Citations: 242     Fields:    Translation:Animals
    579. Deng J, Miller SA, Wang HY, Xia W, Wen Y, Zhou BP, Li Y, Lin SY, Hung MC. beta-catenin interacts with and inhibits NF-kappa B in human colon and breast cancer. Cancer Cell. 2002 Oct; 2(4):323-34. PMID: 12398896.
      Citations: 162     Fields:    Translation:HumansCells
    580. Ding Y, Wen Y, Spohn B, Wang L, Xia W, Kwong KY, Shao R, Li Z, Hortobagyi GN, Hung MC, Yan DH. Proapoptotic and antitumor activities of adenovirus-mediated p202 gene transfer. Clin Cancer Res. 2002 Oct; 8(10):3290-7. PMID: 12374701.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    581. Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12747-52. PMID: 12242338; PMCID: PMC130531.
      Citations: 24     Fields:    Translation:HumansCells
    582. Vorburger SA, Pataer A, Yoshida K, Barber GN, Xia W, Chiao P, Ellis LM, Hung MC, Swisher SG, Hunt KK. Role for the double-stranded RNA activated protein kinase PKR in E2F-1-induced apoptosis. Oncogene. 2002 Sep 12; 21(41):6278-88. PMID: 12214268.
      Citations: 12     Fields:    Translation:HumansCells
    583. Tari AM, Lim SJ, Hung MC, Esteva FJ, Lopez-Berestein G. Her2/neu induces all-trans retinoic acid (ATRA) resistance in breast cancer cells. Oncogene. 2002 Aug 08; 21(34):5224-32. PMID: 12149644.
      Citations: 19     Fields:    Translation:HumansCells
    584. Villaret D, Glisson B, Kenady D, Hanna E, Carey M, Gleich L, Yoo GH, Futran N, Hung MC, Anklesaria P, Heald AE. A multicenter phase II study of tgDCC-E1A for the intratumoral treatment of patients with recurrent head and neck squamous cell carcinoma. Head Neck. 2002 Jul; 24(7):661-9. PMID: 12112540.
      Citations: 16     Fields:    Translation:HumansCTClinical Trials
    585. Zhou BP, Hung MC. Novel targets of Akt, p21(Cipl/WAF1), and MDM2. Semin Oncol. 2002 Jun; 29(3 Suppl 11):62-70. PMID: 12138399.
      Citations: 25     Fields:    Translation:HumansCells
    586. Tan M, Jing T, Lan KH, Neal CL, Li P, Lee S, Fang D, Nagata Y, Liu J, Arlinghaus R, Hung MC, Yu D. Phosphorylation on tyrosine-15 of p34(Cdc2) by ErbB2 inhibits p34(Cdc2) activation and is involved in resistance to taxol-induced apoptosis. Mol Cell. 2002 May; 9(5):993-1004. PMID: 12049736.
      Citations: 47     Fields:    Translation:HumansCells
    587. Meric F, Hung MC, Hortobagyi GN, Hunt KK. HER2/neu in the management of invasive breast cancer. J Am Coll Surg. 2002 Apr; 194(4):488-501. PMID: 11949754.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    588. Wang SC, Shao R, Pao AY, Zhang S, Hung MC, Su LK. Inhibition of cancer cell growth by BRCA2. Cancer Res. 2002 Mar 01; 62(5):1311-4. PMID: 11888897.
      Citations: 21     Fields:    Translation:AnimalsCells
    589. Oksvold M, Huitfeldt H, Stang E, Madshus I. Localizing the EGF receptor. Nat Cell Biol. 2002 Feb; 4(2):E22; author reply E22-3. PMID: 11835048.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    590. Cristofanilli M, De Gasperis G, Zhang L, Hung MC, Gascoyne PR, Hortobagyi GN. Automated electrorotation to reveal dielectric variations related to HER-2/neu overexpression in MCF-7 sublines. Clin Cancer Res. 2002 Feb; 8(2):615-9. PMID: 11839684.
      Citations: 15     Fields:    Translation:HumansCells
    591. Meric F, Lee WP, Sahin A, Zhang H, Kung HJ, Hung MC. Expression profile of tyrosine kinases in breast cancer. Clin Cancer Res. 2002 Feb; 8(2):361-7. PMID: 11839650.
      Citations: 62     Fields:    Translation:Cells
    592. Lee WP, Wen Y, Varnum B, Hung MC. Akt is required for Axl-Gas6 signaling to protect cells from E1A-mediated apoptosis. Oncogene. 2002 Jan 17; 21(3):329-36. PMID: 11821945.
      Citations: 38     Fields:    Translation:HumansCells
    593. Deng J, Kloosterbooer F, Xia W, Hung MC. The NH(2)-terminal and conserved region 2 domains of adenovirus E1A mediate two distinct mechanisms of tumor suppression. Cancer Res. 2002 Jan 15; 62(2):346-50. PMID: 11809676.
      Citations: 5     Fields:    Translation:AnimalsCells
    594. Deng J, Zhang H, Kloosterboer F, Liao Y, Klostergaard J, Levitt ML, Hung MC. Ceramide does not act as a general second messenger for ultraviolet-induced apoptosis. Oncogene. 2002 Jan 03; 21(1):44-52. PMID: 11791175.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    595. Zhou BP, Li Y, Hung MC. HER-2/Neu signaling and therapeutic approaches in breast cancer. Breast Dis. 2002; 15:13-24. PMID: 15687642.
      Citations: 4     Fields:    
    596. Zou Y, Peng H, Zhou B, Wen Y, Wang SC, Tsai EM, Hung MC. Systemic tumor suppression by the proapoptotic gene bik. Cancer Res. 2002 Jan 01; 62(1):8-12. PMID: 11782349.
      Citations: 29     Fields:    Translation:AnimalsCells
    597. Meisler A. E1A is an oncogene and may immortalize normal cells, especially in combination with other oncoproteins. J Clin Oncol. 2001 Nov 01; 19(21):4183-4. PMID: 11689591.
      Citations:    Fields:    Translation:Humans
    598. Yang HY, Shao R, Hung MC, Lee MH. p27 Kip1 inhibits HER2/neu-mediated cell growth and tumorigenesis. Oncogene. 2001 Jun 21; 20(28):3695-702. PMID: 11439332.
      Citations: 20     Fields:    Translation:AnimalsCells
    599. Makino K, Yu D, Hung MC. Transcriptional upregulation and activation of p55Cdc via p34(cdc2) in Taxol-induced apoptosis. Oncogene. 2001 May 03; 20(20):2537-43. PMID: 11420663.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    600. Wen Y, Hu MC, Makino K, Spohn B, Bartholomeusz G, Yan DH, Hung MC. HER-2/neu promotes androgen-independent survival and growth of prostate cancer cells through the Akt pathway. Cancer Res. 2000 Dec 15; 60(24):6841-5. PMID: 11156376.
      Citations: 129     Fields:    Translation:HumansAnimalsCells
    601. Yu D, Hung MC. Overexpression of ErbB2 in cancer and ErbB2-targeting strategies. Oncogene. 2000 Dec 11; 19(53):6115-21. PMID: 11156524.
      Citations: 147     Fields:    Translation:HumansAnimals
    602. Yin S, Hung MC, Goodrich DW. Adenovirus-mediated N5 gene transfer inhibits tumor cell proliferation by induction of apoptosis. Cancer Gene Ther. 2000 Jul; 7(7):985-90. PMID: 10917200.
      Citations:    Fields:    Translation:HumansCells
    603. Xia W, Lau YK, Hu MC, Li L, Johnston DA, Sheng Sj, El-Naggar A, Hung MC. High tumoral maspin expression is associated with improved survival of patients with oral squamous cell carcinoma. Oncogene. 2000 May 11; 19(20):2398-403. PMID: 10828881.
      Citations: 32     Fields:    Translation:HumansCells
    604. Lu Y, Lin YZ, LaPushin R, Cuevas B, Fang X, Yu SX, Davies MA, Khan H, Furui T, Mao M, Zinner R, Hung MC, Steck P, Siminovitch K, Mills GB. The PTEN/MMAC1/TEP tumor suppressor gene decreases cell growth and induces apoptosis and anoikis in breast cancer cells. Oncogene. 1999 Nov 25; 18(50):7034-45. PMID: 10597304.
      Citations: 98     Fields:    Translation:HumansCells
    605. Pusztai L, Esteva FJ, Cristofanilli M, Hung MC, Hortobagyi GN. Chemo-signal therapy, an emerging new approach to modify drug resistance in breast cancer. Cancer Treat Rev. 1999 Oct; 25(5):271-7. PMID: 10544071.
      Citations: 3     Fields:    Translation:HumansCells
    606. Tari AM, Hung MC, Li K, Lopez-Berestein G. Growth inhibition of breast cancer cells by Grb2 downregulation is correlated with inactivation of mitogen-activated protein kinase in EGFR, but not in ErbB2, cells. Oncogene. 1999 Feb 11; 18(6):1325-32. PMID: 10022814.
      Citations: 25     Fields:    Translation:HumansCells
    607. Yan DH, Wen Y, Spohn B, Choubey D, Gutterman JU, Hung MC. Reduced growth rate and transformation phenotype of the prostate cancer cells by an interferon-inducible protein, p202. Oncogene. 1999 Jan 21; 18(3):807-11. PMID: 9989832.
      Citations: 4     Fields:    Translation:HumansCells
    608. Su LK, Wang SC, Qi Y, Luo W, Hung MC, Lin SH. Characterization of BRCA2: temperature sensitivity of detection and cell-cycle regulated expression. Oncogene. 1998 Nov 05; 17(18):2377-81. PMID: 9811469.
      Citations: 7     Fields:    Translation:HumansCells
    609. Xing X, Zhang S, Chang JY, Tucker SD, Chen H, Huang L, Hung MC. Safety study and characterization of E1A-liposome complex gene-delivery protocol in an ovarian cancer model. Gene Ther. 1998 Nov; 5(11):1538-44. PMID: 9930307.
      Citations: 8     Fields:    Translation:Animals
    610. Deng J, Xia W, Hung MC. Adenovirus 5 E1A-mediated tumor suppression associated with E1A-mediated apoptosis in vivo. Oncogene. 1998 Oct 29; 17(17):2167-75. PMID: 9811448.
      Citations: 8     Fields:    Translation:AnimalsCells
    611. Zhang L, Lau YK, Xi L, Hong RL, Kim DS, Chen CF, Hortobagyi GN, Chang C, Hung MC. Tyrosine kinase inhibitors, emodin and its derivative repress HER-2/neu-induced cellular transformation and metastasis-associated properties. Oncogene. 1998 Jun 04; 16(22):2855-63. PMID: 9671406.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    612. Yu D, Liu B, Jing T, Sun D, Price JE, Singletary SE, Ibrahim N, Hortobagyi GN, Hung MC. Overexpression of both p185c-erbB2 and p170mdr-1 renders breast cancer cells highly resistant to taxol. Oncogene. 1998 Apr 23; 16(16):2087-94. PMID: 9572489.
      Citations: 23     Fields:    Translation:HumansCells
    613. Le XF, Vallian S, Mu ZM, Hung MC, Chang KS. Recombinant PML adenovirus suppresses growth and tumorigenicity of human breast cancer cells by inducing G1 cell cycle arrest and apoptosis. Oncogene. 1998 Apr 09; 16(14):1839-49. PMID: 9583681.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    614. Chen H, Yu D, Chinnadurai G, Karunagaran D, Hung MC. Mapping of adenovirus 5 E1A domains responsible for suppression of neu-mediated transformation via transcriptional repression of neu. Oncogene. 1997 Apr 24; 14(16):1965-71. PMID: 9150363.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    615. Luo W, Wood CG, Earley K, Hung MC, Lin SH. Suppression of tumorigenicity of breast cancer cells by an epithelial cell adhesion molecule (C-CAM1): the adhesion and growth suppression are mediated by different domains. Oncogene. 1997 Apr 10; 14(14):1697-704. PMID: 9135071.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    616. Xing X, Liu V, Xia W, Stephens LC, Huang L, Lopez-Berestein G, Hung MC. Safety studies of the intraperitoneal injection of E1A--liposome complex in mice. Gene Ther. 1997 Mar; 4(3):238-43. PMID: 9135737.
      Citations: 4     Fields:    Translation:AnimalsCells
    617. Pollock RE, Lang A, El-Naggar AK, Radinsky R, Hung MC. Enhanced MDM2 Oncoprotein Expression in Soft Tissue Sarcoma: Several Possible Regulatory Mechanisms. Sarcoma. 1997; 1(1):23-9. PMID: 18521197; PMCID: PMC2373579.
      Citations:    
    618. Chang JY, Xia W, Shao R, Hung MC. Inhibition of intratracheal lung cancer development by systemic delivery of E1A. Oncogene. 1996 Oct 03; 13(7):1405-12. PMID: 8875978.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    619. Yu D, Liu B, Tan M, Li J, Wang SS, Hung MC. Overexpression of c-erbB-2/neu in breast cancer cells confers increased resistance to Taxol via mdr-1-independent mechanisms. Oncogene. 1996 Sep 19; 13(6):1359-65. PMID: 8808711.
      Citations: 35     Fields:    Translation:HumansCells
    620. Tang P, Klostergaard J. Length of the linking domain of human pro-tumor necrosis factor determines the cleavage processing. Biochemistry. 1996 Jun 25; 35(25):8226-33. PMID: 8679577.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    621. Tang P, Klostergaard J. Human pro-tumor necrosis factor is a homotrimer. Biochemistry. 1996 Jun 25; 35(25):8216-25. PMID: 8679576.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    622. Russell K, Lee E, Kiyokawa N, Hideyuki S, Hung M. Effects of estrogen receptor expression on growth and transformation of cells overexpressing neu. Oncol Rep. 1996 May; 3(3):433-7. PMID: 21594387.
      Citations:    Fields:    
    623. Ueno N, Kiyokawa N, Hung M. Growth suppression of low HER-2/neu-expressing breast cancer cell line MDA-MB-435 by tyrosine kinase inhibitor emodin. Oncol Rep. 1996 May; 3(3):509-11. PMID: 21594402.
      Citations: 3     Fields:    
    624. Zhang L, Hung MC. Sensitization of HER-2/neu-overexpressing non-small cell lung cancer cells to chemotherapeutic drugs by tyrosine kinase inhibitor emodin. Oncogene. 1996 Feb 01; 12(3):571-6. PMID: 8637714.
      Citations: 27     Fields:    Translation:HumansCells
    625. Yu D, Matin A, Xia W, Sorgi F, Huang L, Hung MC. Liposome-mediated in vivo E1A gene transfer suppressed dissemination of ovarian cancer cells that overexpress HER-2/neu. Oncogene. 1995 Oct 05; 11(7):1383-8. PMID: 7478560.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    626. Miller S, Hung M. Regulation of her2/neu gene-expression (review). Oncol Rep. 1995 Jul; 2(4):497-503. PMID: 21597764.
      Citations: 5     Fields:    
    627. Matin A, Xie Y, Kao M, Hung M. Rodent p53 suppresses the transforming activity of the activated Neu oncogene by modulating the Basal promoter activity of Neu. Int J Oncol. 1995 May; 6(5):1087-92. PMID: 21556644.
      Citations: 1     Fields:    
    628. Gee JE, Yen RL, Hung MC, Hogan ME. Triplex formation at the rat neu oncogene promoter. Gene. 1994 Nov 04; 149(1):109-14. PMID: 7958974.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    629. Reardon D, Hung M. Suppressed autophosphorylation and tyrosine kinase-activity in revertant cell-lines expressing rat Neu oncogene. Oncol Rep. 1994 Sep; 1(5):895-902. PMID: 21607462.
      Citations:    Fields:    
    630. Miller S, Hung M. Her2 Neu overexpression counteracts the growth effects of C-myc in breast-cancer cells. Int J Oncol. 1994 Apr; 4(4):965-9. PMID: 21567007.
      Citations: 1     Fields:    
    631. Miller S, Suen T, Sexton T, Hung M. Mechanisms of deregulated her2/neu expression in breast-cancer cell-lines. Int J Oncol. 1994 Mar; 4(3):599-608. PMID: 21566965.
      Citations: 2     Fields:    
    632. Yen R, Hung M. Complex regulation of the adenovirus e2 promoter by the viral oncoproteins e1a and e7 and tumor-suppressor rb. Int J Oncol. 1994 Jan; 4(1):109-15. PMID: 21566898.
      Citations: 1     Fields:    
    633. Reardon D, Xie Y, Hung M. The microfocus assay system (mfas) - a simple quantitative assay to identify inhibitory drugs targeted against specific oncogenes. Oncol Rep. 1994 Jan; 1(1):37-41. PMID: 21607302.
      Citations:    Fields:    
    634. Erratum. Cancer Research. 62:4167.
    635. Cancer. Journal of Clinical Ligand Assay. 22:326-330.
    636. Fabrication of silica nanochannels via scanned coaxial electrospinning. 244-246.
    637. HER2/neu overexpression counteracts the growth effects of c-myc in breast cancer cells. International Journal of Oncology. 4:965-969.
    638. The hippo coactivator YAP1 mediates EGFR overexpression and confers chemoresistance in esophageal cancer. Clinical Cancer Research. 21:2580-2590.
    639. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nature Communications. 6.
    640. Regulation of therapeutic resistance in cancers by receptor tyrosine kinases. American Journal of Cancer Research. 6:827-842.
    641. Inhibition of VEGF 165/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis. Scientific Reports. 6.
    642. Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma. Oncotarget. 6:23807-23819.
    643. Regulation and role of EZH2 in cancer. Cancer Research and Treatment. 46:209-222.
    644. Breast cancer gene therapy. 705-740.
    645. Activation of keap1/nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. American Journal of Translational Research. 6:649-663.
    646. Sodium/glucose co-transporter 1 expression increases in human diseased prostate. Journal of Cancer Science and Therapy. 4:306-312.
    647. Erratum. Nature Cell Biology. 13:1467.
    648. Erratum. Cell. 151:913-914.
    649. P27kip1 down-regulation is associated with trastuzumab resistance in breast cancer cells (Cancer Research (June 1, 2004) 64 (3981-3986)). Cancer Research. 68:10005.
    650. Deubiquitylation and stabilization of PTEN by USP13. Nature Cell Biology.
    651. Preclinical and clinical study of HER-2/neu-targeting cancer gene therapy. Advanced Drug Delivery Reviews. 30:219-227.
    652. Implication of nuclear EGFR in the development of resistance to anticancer therapies. BioMedicine (Netherlands). 1:2-10.
    653. Nuclear functions and trafficking of receptor tyrosine Kinases. 159-176.
    654. Powering Tumor Metastasis with Recycled Fuel. Cancer Cell. 30:374-375.
    655. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 30:925-939.
    656. Correction. Oncotarget. 7:80101.
    657. Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. Oncotarget. 7:25742-25754.
    658. Translational research. Drugs of Today. 38:21-35.
    659. Erratum. Nature Cell Biology. 13:1466.
    660. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Research. 25:225-236.
    661. AKT1 inhibits epithelial-to-mesenchymal transition in breast cancer through phosphorylation-dependent twist1 degradation. Cancer Research. 76:1451-1462.
    662. Electrospinning of silica nanochannels for single molecule detection. Applied Physics Letters. 88:1-3.
    663. Tumor suppression activity of adenovirus 5 E1A in prostate cancer. Cancer Research Therapy and Control. 7:221-223.
    664. Role of tryptophanyl and tyrosyl residues in maintaining the active conformation of α-bungarotoxin. Indian Journal of Biochemistry and Biophysics. 18.
    665. Erratum. Cancer Research. 65:2045.
    666. High-resolution profiling of histone h3 lysine 36 trimethylation in metastatic renal cell carcinoma. Oncogene.
    667. Upregulation of lactate dehydrogenase a by 14-3-3ζ leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. 7:35270-35283.
    668. Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases. FEBS Journal. 282:3693-3721.
    669. Nanofluidic Strategies for Cancer Research. 114-149.
    670. Regulation of HER2/neu gene expression. Oncology Reports. 2:497-503.
    671. Altered expression and splicing of ESRP1 in malignant melanoma correlates with epithelial- mesenchymal status and Tumor-Associated immune cytolytic activity. Cancer immunology research. 4:552-561.
    672. Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model. American Journal of Cancer Research. 5:3534-3547.
    673. Nuclear functions of receptor tyrosine kinases. 77-109.
    674. The VEGF-C/Flt-4 Axis Promotes Invasion and Metastasis of Cancer Cells (DOI. Cancer Cell. 14:274-277.
    675. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis (Journal of Clinical Investigation (2012) 122, 1 (419) DOI. Journal of Clinical Investigation. 122:419.
    676. Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination. Nature Communications. 6.
    677. Role of cancer stem cells in brain tumors. BioMedicine (Netherlands). 2:84-91.
    678. PTEN key to Herceptin response in Her2-positive breast cancer. Cancer Biology and Therapy. 3:796.
    679. Cancer Gene Therapy by Viral and Non-viral Vectors.
    680. MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Cα-based triple-negative breast cancer cells. Oncotarget. 7:59845-59859.
    681. Severe hepatitis promotes hepatocellular carcinoma recurrence via NF-κb pathway-mediated epithelial-mesenchymal transition after resection. Clinical Cancer Research. 22:1800-1812.
    682. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nature Communications. 7.
    683. Novel signaling pathways in breast cancer. 823-839.
    684. ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. Cancer Cell. 30:723-736.
    685. miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. Oncotarget. 6:25962-25974.
    686. The LINK-A lncRNA activates normoxic HIF1α signalling in triple-negative breast cancer. Nature Cell Biology. 18:213-224.
    687. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Reports. 13:1046-1058.
    688. A perspective on anti-EGFR therapies targeting triple-negative breast cancer. American Journal of Cancer Research. 6:1609-1623.
    689. The microfocus assay system (MFAS). Oncology Reports. 1:37-41.
    690. Erratum. Oncogene. 23:8857.
    691. JARID1D is a suppressor and prognostic marker of prostate cancer invasion and metastasis. Cancer Research. 76:831-843.
    692. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. American Journal of Cancer Research. 5:3624-3634.
    693. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 28:610-622.
    694. Preface. Unknown Journal. xi-xii.
    695. Proteasome inhibition enhances the killing effect of BikDD gene therapy. American Journal of Translational Research. 7:319-327.
    696. Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. Cancer Letters. 388:54-63.
    697. The expression patterns of ER, PR, HER2, CK5/6, EGFR, KI-67 and AR by immunohistochemical analysis in breast cancer cell lines. Breast Cancer: Basic and Clinical Research. 4:35-41.
    698. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nature Communications. 7.
    699. Non-canonical signaling mode of the epidermal growth factor receptor family. American Journal of Cancer Research. 5:2944-2958.
    700. Oncogenic functions of Gli1 in pancreatic adenocarcinoma are supported by its PRMT1-mediated methylation. Cancer Research. 76:7049-7058.
    701. High level of STK-15 expression in primary breast tumors correlates with nuclear grade. Breast Cancer Research and Treatment. 69:266.
    702. EGFR signaling enhances aerobic glycolysis in triple-negative breast cancer cells to promote tumor growth and immune escape. Cancer Research. 76:1284-1296.
    703. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Frontiers in Oncology. 2.
    704. Cancer Gene Therapy by Tissue-specific and Cancer-targeting Promoters. 79-96.
    705. The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer. Cancer and Metastasis Reviews. 35:575-588.
    706. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. Journal of Clinical Investigation. 125:4529-4543.
    707. Complex regulation of the adenovirus E2 promoter by the viral oncoproteins E1A and E7 and tumor suppressor Rb. International Journal of Oncology. 4:109-115.
    708. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nature Communications. 7.
    709. Development of automated high throughput single molecular microfluidic detection platform for signal transduction analysis.
    710. STK15/BTAK/aurora-A expression in ductal carcinoma in situ of the breast. Breast Cancer Research and Treatment. 69:250.
    711. Role of IκB kinase in tumorigenesis. Future Oncology. 1:67-78.
    712. Nanofluidic devices for single molecule identification. Journal of Photopolymer Science and Technology. 21:531-536.
    713. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nature Communications. 7.
    714. Determination of protein concentration with two-dimensional (2D) Photon burst diagrams using microfluidic channel. 865-867.
    715. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nature Medicine. 22:194-201.
    716. Erratum. Proceedings of the National Academy of Sciences of the United States of America. 99:15245.
    717. Growth inhibition of breast cancer cells by celecoxib. Breast Cancer Research and Treatment. 69:234.
    718. Beyond anti-VEGF. American Journal of Translational Research. 5:393-403.
    719. GSK3β inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget. 7:57131-57144.
    720. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. American Journal of Cancer Research. 6:628-638.
    721. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene.
    722. Erratum. Drug Resistance Updates. 6:295-296.
    723. Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope. Biophysical Journal. 111:2214-2227.
    724. On mammary gland growth factors. Cold Spring Harbor perspectives in biology. 4.
    725. Dicer elicits paclitaxel chemosensitization and suppresses cancer stemness in breast cancer by repressing AXL. Cancer Research. 76:3916-3928.
    726. Aurora A kinase activates YAP signaling in triple-negative breast cancer. Oncogene.
    727. S6k1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. American Journal of Translational Research. 6:361-376.
    728. The VEGF-C/Flt-4 Axis Promotes Invasion and Metastasis of Cancer Cells (DOI. Cancer Cell. 11:207.
    729. Optofluidic single molecule flow proteometry.
    730. Efficient systemic DNA delivery to the tumor by self-assembled nanoparticle. Journal of Nanoparticle Research. 16.
    731. The ZNF304-integrin axis protects against anoikis in cancer. Nature Communications. 6.
    732. Suppressed autophosphorylation and tyrosine kinase activity in revertant cell lines expressing rat neu oncogene. Oncology Reports. 1:895-902.
    733. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. American Journal of Cancer Research. 5:3560-3569.
    734. Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis. American Journal of Translational Research. 5:441-449.
    735. Mechanisms of deregulated HER2/neu expression in breast cancer cell lines. International Journal of Oncology. 4:599-608.
    736. The fabrication and testing of electrospun silica nanofiber membranes for the detection of proteins. Nanotechnology. 19.
    737. Advances in Liposome-Based Targeted Gene Therapy of Cancer. 113-133.
    738. Rodent p53 suppresses the transforming activity of the activated neu oncogene by modulating the basal promoter activity of neu. International Journal of Oncology. 6:1087-1092.
    739. A novel alteration in the epidermal growth factor receptor gene is frequently detected in human non-small cell lung cancer. Lung Cancer. 6:65-72.
    740. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1α activation, tumorigenesis and metastasis. Nature Cell Biology. 19:38-51.
    741. Editorial. American Journal of Translational Research. 1.
    742. IκB Kinase Promotes Tumorigenesis through Inhibition of Forkhead FOXO3a (PII. Cell. 129:1427-1428.
    743. Phosphorylation of ezh2 at t416 by cdk2 contributes to the malignancy of triple negative breast cancers. American Journal of Translational Research. 7:1009-1020.
    744. Advances in Experimental Medicine and Biology. Advances in Experimental Medicine and Biology. 608.
    745. EZH2. American Journal of Translational Research. 4:364-375.
    746. Signal transduction of HER-2/neu receptor tyrosine kinase. Cancer Bulletin. 47:109-118.
    HUNG's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (1450)
    Explore
    _
    Co-Authors (261)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _