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MIEN-CHIE HUNG
Title
Professor
Institution
MD Anderson
Department
Molecular & Cellular Oncology
Address
1515 Holcombe Blvd
Houston TX 77030-4009
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Bibliographic
selected publications
Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can
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to make corrections and additions.
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PMC Citations
indicate the number of times the publication was cited by articles in PubMed Central, and the
Altmetric
score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.)
Fields
are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication.
Translation
tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
Wang WJ, Tang HT, Ou SC, Shen WJ, Chen CY, Li YC, Chang SY, Chang WC, Hsueh PR, Huang ST,
Hung MC
. Novel SARS-CoV-2 inhibition properties of the anti-cancer Kang Guan Recipe herbal formula. Cancer Lett. 2024 Aug 26; 217198.
PMID:
39197583
.
Citations:
Fields:
Neo
Neoplasms
Lei G, Mao C, Horbath AD, Yan Y, Cai S,
Yao J
, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q,
Lu Z
, Zhuang L, Chen MK, Alapati A, Yap TA,
Hung MC
, You MJ,
Piwnica-Worms H
, Gan B, Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC,
You MJ
, Piwnica-Worms H,
Gan B
. BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024 Aug 02; 14(8):1476-1495.
PMID:
38552003
; PMCID:
PMC11296921
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen Z, Yu M, Zhang B, Jin L, Yu Q, Liu S, Zhou B, Yan J, Zhang W, Li X, Xu Y, Xiao Y, Zhou J, Fan J,
Hung MC
, Ye Q, Li H, Guo L. SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion. Oncoimmunology. 2024; 13(1):2376264.
PMID:
38988824
; PMCID:
PMC11236293
.
Citations:
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Liu CH, Shen PC, Lin WJ, Liu HC, Tsai MH, Huang TY, Chen IC, Lai YL, Wang YD,
Hung MC
, Cheng WC. LipidSig 2.0: integrating lipid characteristic insights into advanced lipidomics data analysis. Nucleic Acids Res. 2024 Jul 05; 52(W1):W390-W397.
PMID:
38709887
; PMCID:
PMC11223864
.
Citations:
Fields:
Bio
Biochemistry
Feng LL, Bie SY, Deng ZH, Bai SM, Shi J, Qin CL, Liu HL, Li JX, Chen WY, Zhou JY, Jiao CM, Ma Y, Qiu MB, Ai HS, Zheng J,
Hung MC
, Wang YL, Wan XB, Fan XJ. Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2322972121.
PMID:
38968116
; PMCID:
PMC11252754
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Cells
Yamaguchi H
, Hsu JM, Sun L, Wang SC,
Hung MC
. Advances and prospects of biomarkers for immune checkpoint inhibitors. Cell Rep Med. 2024 Jul 16; 5(7):101621.
PMID:
38906149
; PMCID:
PMC11293349
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Le UNP, Chang YJ, Lu CH, Chen Y, Su WC, Chao ST, Baltina LA, Petrova SF, Li SR,
Hung MC
, Lai MMC, Baltina LA, Lin CW. Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants. Antiviral Res. 2024 Jul; 227:105920.
PMID:
38821317
.
Citations:
Fields:
Ant
Anti-Infective Agents
Vir
Virology
Translation:
Humans
Animals
Cells
Chen CY, Wang WJ, Wu CS, Wang SC, Chang WC,
Hung MC
. Tannic acids and proanthocyanidins in tea inhibit SARS-CoV-2 variants infection. Am J Cancer Res. 2024; 14(5):2555-2569.
PMID:
38859869
; PMCID:
PMC11162682
.
Citations:
1
Lin CH, Chin Y, Zhou M, Sobol RW,
Hung MC
, Tan M. Protein lipoylation: mitochondria, cuproptosis, and beyond. Trends Biochem Sci. 2024 Aug; 49(8):729-744.
PMID:
38714376
.
Citations:
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Fu J,
Ling J
, Li CF, Tsai CL, Yin W, Hou J, Chen P, Cao Y,
Kang Y
, Sun Y, Xia X, Jiang Z, Furukawa K, Lu Y, Wu M,
Huang Q
,
Yao J
, Hawke DH, Pan BF, Zhao J, Huang J, Wang H, Bahassi EIM, Stambrook PJ,
Huang P
,
Fleming JB
,
Maitra A
,
Tainer JA
,
Hung MC
, Lin C,
Chiao PJ
. Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nat Commun. 2024 Apr 11; 15(1):3149.
PMID:
38605037
; PMCID:
PMC11009390
.
Citations:
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Chen HH, Yu HI, Chang JJ, Li CW, Yang MH,
Hung MC
, Tarn WY. DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1. Cell Rep. 2024 Mar 26; 43(3):113937.
PMID:
38489268
.
Citations:
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Jabbarzadeh Kaboli P, Chen HF, Babaeizad A, Roustai Geraylow K,
Yamaguchi H
,
Hung MC
. Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer. Cancer Lett. 2024 Apr 28; 588:216780.
PMID:
38462033
.
Citations:
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Xie P, Yu M, Zhang B, Yu Q, Zhao Y, Wu M, Jin L, Yan J, Zhou B, Liu S, Li X, Zhou C, Zhu X, Huang C, Xu Y, Xiao Y, Zhou J, Fan J,
Hung MC
, Ye Q, Guo L, Li H, Yu Q, Wu M, Yan J. CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma. J Hepatol. 2024 Jul; 81(1):93-107.
PMID:
38403027
.
Citations:
2
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Cells
Liu C, Zhou C, Xia W, Zhou Y, Qiu Y, Weng J, Zhou Q, Chen W, Wang YN, Lee HH, Wang SC, Kuang M, Yu D, Ren N,
Hung MC
. Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma. Nat Commun. 2024 Feb 02; 15(1):1009.
PMID:
38307859
; PMCID:
PMC10837126
.
Citations:
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Huang YK, Cheng WC, Kuo TT, Yang JC, Wu YC, Wu HH, Lo CC, Hsieh CY, Wong SC, Lu CH, Wu WL, Liu SJ, Li YC, Lin CC, Shen CN,
Hung MC
, Lin JT, Yeh CC, Sher YP. Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nat Cancer. 2024 Mar; 5(3):400-419.
PMID:
38267627
.
Citations:
Fields:
Neo
Neoplasms
Translation:
Humans
Chen HF, Chang CT, Hsu KW, Peng PH, Lai JC,
Hung MC
, Wu KJ. Epigenetic regulation of asymmetric cell division by the LIBR-BRD4 axis. Nucleic Acids Res. 2024 Jan 11; 52(1):154-165.
PMID:
37986225
; PMCID:
PMC10783485
.
Citations:
Fields:
Bio
Biochemistry
Liu CH, Lai YL, Shen PC, Liu HC, Tsai MH, Wang YD, Lin WJ, Chen FH, Li CY, Wang SC,
Hung MC
, Cheng WC. DriverDBv4: a multi-omics integration database for cancer driver gene research. Nucleic Acids Res. 2024 Jan 05; 52(D1):D1246-D1252.
PMID:
37956338
; PMCID:
PMC10767848
.
Citations:
Fields:
Bio
Biochemistry
Translation:
Humans
Chang CW, Wang S, Huang J, Zeng S, Zhang X,
Hung MC
, Hou J. Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024 Jan 02; 134(1).
PMID:
37883181
; PMCID:
PMC10760963
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Yamaguchi H
, Chang LC, Chang OS, Chen YF, Hsiao YC, Wu CS,
Hung MC
. MRCK as a Potential Target for Claudin-Low Subtype of Breast Cancer. Int J Biol Sci. 2024; 20(1):1-14.
PMID:
38164185
; PMCID:
PMC10750295
.
Citations:
Fields:
Bio
Biology
Translation:
Humans
Cells
Chou WC, Chen WT, Kuo CT, Chang YM, Lu YS, Li CW,
Hung MC
, Shen CY. Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer. Cell Rep. 2024 01 23; 43(1):113641.
PMID:
38165805
.
Citations:
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Wu CS, Li YC, Peng SL, Chen CY, Chen HF, Hsueh PR, Wang WJ, Liu YY, Jiang CL, Chang WC, Wang SC,
Hung MC
. Coffee as a dietary strategy to prevent SARS-CoV-2 infection. Cell Biosci. 2023 Nov 14; 13(1):210.
PMID:
37964389
; PMCID:
PMC10644613
.
Citations:
Su WC, Chen ZY, Chang YS, Jeng KS, Le UNP, Chou YC, Kuo LL, Melano I, Wang WJ, Song YC, Li SR,
Hung MC
, Lai MMC, Lin CW. Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization. Antiviral Res. 2023 12; 220:105744.
PMID:
37944823
.
Citations:
Fields:
Ant
Anti-Infective Agents
Vir
Virology
Translation:
Humans
Cells
Dabrell SN, Li YC,
Yamaguchi H
, Chen HF,
Hung MC
. Herbal Compounds Dauricine and Isoliensinine Impede SARS-CoV-2 Viral Entry. Biomedicines. 2023 Oct 27; 11(11).
PMID:
38001915
; PMCID:
PMC10669532
.
Citations:
Lee PC, Kumar V, Sivakumar G, Tseng TY, Li YC, Jiang YC, Hsiao YC, Lin HW, Chang CS,
Hung MC
. Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers. Am J Cancer Res. 2023; 13(10):4693-4707.
PMID:
37970360
; PMCID:
PMC10636659
.
Citations:
Koller P, Baran N, Harutyunyan K, Cavazos A,
Mallampati S
, Chin RL, Jiang Z, Sun X, Lee HH, Hsu JL, Williams P, Huang X,
Curran MA
,
Hung MC
,
Konopleva M
. PD-1 blockade in combination with dasatinib potentiates induction of anti-acute lymphocytic leukemia immunity. J Immunother Cancer. 2023 10; 11(10).
PMID:
37793852
; PMCID:
PMC10551962
.
Citations:
Fields:
Neo
Neoplasms
The
Therapeutics
Translation:
Humans
Animals
Melano I, Cheng WC, Kuo LL, Liu YM, Chou YC,
Hung MC
, Lai MMC, Sher YP, Su WC. A disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expression. Microbiol Spectr. 2023 Sep 15; e0385422.
PMID:
37713503
; PMCID:
PMC10581035
.
Citations:
1
Fields:
Mic
Microbiology
Yamaguchi H
,
Hung MC
. PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to shape anti-tumor immunity. Cancer Cell. 2023 Oct 09; 41(10):1701-1704.
PMID:
37683640
.
Citations:
Fields:
Neo
Neoplasms
Chen HF, Wang WJ, Chen CY, Chang WC, Hsueh PR, Peng SL, Wu CS, Chen Y, Huang HY, Shen WJ, Wang SC,
Hung MC
. The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2. Elife. 2023 08 29; 12.
PMID:
37642993
; PMCID:
PMC10465125
.
Citations:
2
Fields:
Bio
Biology
Translation:
Humans
Cells
Sun X, Wang WJ, Lang J,
Yang R
, Shen WJ, Sun L, Hsu JM, Chan LC, Li CW, Xia W, Ke B, Yao G, Huang K, Lee PC, Koller PB,
Hung MC
. Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity. Int J Biol Sci. 2023; 19(14):4644-4656.
PMID:
37781042
; PMCID:
PMC10535704
.
Citations:
1
Fields:
Bio
Biology
Translation:
Humans
Animals
Hou J, Li T, Hsu JM, Zhang X,
Hung MC
. Gasdermins and cancers. Semin Immunol. 2023 11; 70:101833.
PMID:
37647772
.
Citations:
2
Fields:
All
Allergy and Immunology
Translation:
Humans
Zhang Y, Zhao Z, Huang LA, Liu Y,
Yao J
, Sun C, Li Y, Zhang Z, Ye Y,
Yuan F
, Nguyen TK, Garlapati NR, Wu A, Egranov SD,
Caudle AS
,
Sahin AA
, Lim B,
Beretta L
,
Calin GA
,
Yu D
,
Hung MC
,
Curran MA
, Rezvani K,
Gan B
,
Tan Z
, Han L, Lin C, Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 08 08; 35(8):1457-1473.e13.
PMID:
37329887
; PMCID:
PMC10712687
.
Citations:
2
Fields:
Cel
Cell Biology
Met
Metabolism
Translation:
Animals
Cells
Wang YN, Lee HH, Jiang Z, Chan LC, Hortobagyi GN,
Yu D
,
Hung MC
. Ribonuclease 1 Enhances Antitumor Immunity against Breast Cancer by Boosting T cell Activation. Int J Biol Sci. 2023; 19(10):2957-2973.
PMID:
37416781
; PMCID:
PMC10321278
.
Citations:
2
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Cho J, Min HY, Lee HJ, Hyun SY, Sim JY, Noh M, Hwang SJ, Park SH, Boo HJ, Lee HJ, Hong S, Park RW, Shin YK,
Hung MC
, Lee HY. RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. J Clin Invest. 2023 May 15; 133(10).
PMID:
37183821
; PMCID:
PMC10178829
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Hong X, Hsieh MT, Tseng TY, Lin HY, Chang HC, Yau ST, Cheng WC, Liao HH, Wu CY, Liu AA, Kuo SC,
Hung MC
, Lee PC, Ke B, Wu MM, Huang KY, Yang PC. Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma. J Biol Chem. 2023 06; 299(6):104814.
PMID:
37178919
; PMCID:
PMC10276293
.
Citations:
2
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Radaram B, Glazer SE, Yang P, Li CW,
Hung MC
,
Gammon ST
,
Alauddin M
,
Piwnica-Worms D
. Evaluation of 89Zr-Labeled Anti-PD-L1 Monoclonal Antibodies Using DFO and Novel HOPO Analogues as Chelating Agents for Immuno-PET. ACS Omega. 2023 May 16; 8(19):17181-17194.
PMID:
37214681
; PMCID:
PMC10193402
.
Citations:
1
Hao X, Shen Y, Chen N, Zhang W, Valverde E, Wu L,
Chan HL
,
Xu Z
,
Yu L
, Gao Y, Bado I, Michie LN,
Rivas CH
, Dominguez LB, Aguirre S, Pingel BC, Wu YH,
Liu F
, Ding Y, Edwards DG, Liu J, Alexander A,
Ueno NT
, Hsueh PR, Tu CY, Liu LC, Chen SH,
Hung MC
, Lim B, Zhang XH. Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. Cell Stem Cell. 2023 05 04; 30(5):648-664.e8.
PMID:
37146584
; PMCID:
PMC10165729
.
Citations:
2
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Shie MY, Fang HY, Kan KW, Ho CC, Tu CY, Lee PC, Hsueh PR, Chen CH, Lee AK, Tien N, Chen JX, Shen YC, Chang JG, Shen YF, Lin TJ, Wang B,
Hung MC
, Cho DY, Chen YW. Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics. Adv Sci (Weinh). 2023 06; 10(16):e2206603.
PMID:
37085943
; PMCID:
PMC10238206
.
Citations:
4
Fields:
Bio
Biomedical Engineering
Translation:
Humans
Cells
Nie L
, Wang YN, Hsu JM, Hou J, Chu YY, Chan LC, Huo L, Wei Y, Deng R, Tang J, Hsu YH, Ko HW, Lim SO, Huang K, Chen MK, Chiu TJ, Cheng CC, Fang YF, Li CW, Goverdhan A, Wu HJ, Lee CC, Wang WL, Hsu J,
Chiao P
, Wang SC,
Hung MC
. Nuclear export signal mutation of epidermal growth factor receptor enhances malignant phenotypes of cancer cells. Am J Cancer Res. 2023; 13(4):1209-1239.
PMID:
37168336
; PMCID:
PMC10164793
.
Citations:
1
Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J,
Hung MC
,
Sood AK
. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2023 03 28; 42(3).
PMID:
37274180
; PMCID:
PMC10237679
.
Citations:
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC,
Liao Z
, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W,
Huff CD
, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC,
Hung MC
, Zhao Z,
Van Nostrand EL
, Zhao R, Lee DF. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nat Commun. 2023 03 27; 14(1):1694.
PMID:
36973285
; PMCID:
PMC10042811
.
Citations:
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Wang HC, Chang WC, Lee DY, Li XG,
Hung MC
. IRG1/Itaconate induces metabolic reprogramming to suppress ER-positive breast cancer cell growth. Am J Cancer Res. 2023; 13(3):1067-1081.
PMID:
37034222
; PMCID:
PMC10077032
.
Citations:
Zhou C, Weng J, Liu C, Liu S, Hu Z, Xie X, Gao D, Zhou Q, Sun J, Xu R, Li H, Shen Y, Yi Y, Shi Y, Sheng X, Dong Q,
Hung MC
, Ren N. Disruption of SLFN11 Deficiency-Induced CCL2 Signaling and Macrophage M2 Polarization Potentiates Anti-PD-1 Therapy Efficacy in Hepatocellular Carcinoma. Gastroenterology. 2023 06; 164(7):1261-1278.
PMID:
36863689
.
Citations:
4
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Cells
Liu H, Ou J,
Hung MC
, Chen X. Immune checkpoint blockades therapy of melanoma. Sci Bull (Beijing). 2023 02 26; 68(4):356-358.
PMID:
36774302
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Sun C, Ye Y,
Tan Z
, Liu Y, Li Y, Hu W, Liang K, Egranov SD, Huang LA, Zhang Z, Zhang Y,
Yao J
, Nguyen TK, Zhao Z, Wu A, Marks JR,
Caudle AS
,
Sahin AA
,
Gao J
,
Gammon ST
,
Piwnica-Worms D
, Hu J,
Chiao PJ
,
Yu D
,
Hung MC
,
Curran MA
,
Calin GA
,
Ying H
, Han L, Lin C, Yang L. Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Sci Adv. 2023 02 03; 9(5):eadd6995.
PMID:
36724291
; PMCID:
PMC9891701
.
Citations:
5
Fields:
Sci
Science
Translation:
Humans
Cells
Zheng S, Song J, Linghu D,
Yang R
, Liu B, Xue Z, Chen Q, Liu C, Zhong D,
Hung MC
, Sun L. Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity. Int J Biol Sci. 2023; 19(3):981-993.
PMID:
36778120
; PMCID:
PMC9909994
.
Citations:
1
Fields:
Bio
Biology
Translation:
Humans
Animals
Lin ZS, Chung CC, Liu YC, Chang CH, Liu HC, Liang YY, Huang TL, Chen TM, Lee CH, Tang CH,
Hung MC
, Chen YH. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. Elife. 2023 01 09; 12.
PMID:
36622753
; PMCID:
PMC9829410
.
Citations:
1
Fields:
Bio
Biology
Hou J, Wang S, Miao R, Zhang X,
Hung MC
. Detection of Gasdermin C-Mediated Cancer Cell Pyroptosis. Methods Mol Biol. 2023; 2641:135-146.
PMID:
37074647
.
Citations:
Fields:
Mol
Molecular Biology
Hsieh CY, Chang WC, Lin CC, Chen JH, Lin CY, Liu CH, Lin C,
Hung MC
. Combination treatment of arsenic trioxide and osimertinib in recurrent and metastatic head and neck squamous cell carcinoma. Am J Cancer Res. 2022; 12(11):5049-5061.
PMID:
36504903
; PMCID:
PMC9729903
.
Citations:
Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y,
Yao J
,
Hung MC
,
Calin GA
,
Cheng J
, Lim B, Lehmann LH, Salem JE, Johnson DB,
Curran MA
,
Yu D
, Han L, Darabi R, Yang L, Moslehi JJ, Lin C. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Sci Transl Med. 2022 11 02; 14(669):eabo1981.
PMID:
36322628
; PMCID:
PMC9809130
.
Citations:
6
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Chu YY, Yam C,
Yamaguchi H
,
Hung MC
. Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors. J Biomed Sci. 2022 Oct 25; 29(1):86.
PMID:
36284291
; PMCID:
PMC9594904
.
Citations:
1
Fields:
Med
Medicine (General)
Translation:
Humans
Chu YY, Chen MK, Wei Y, Lee HH,
Xia W
, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC,
Yamaguchi H
, Jiang Z, Liu C, Li CF,
Nie L
, Chan LC, Gao Y, Wang SC, Liu J,
Westin SN
, Lee S,
Sood AK
, Yang L, Hortobagyi GN,
Yu D
,
Hung MC
. Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022 10; 3(10):1211-1227.
PMID:
36253486
; PMCID:
PMC9586872
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Wang SH, Chou WC, Huang HC, Lee TA, Hsiao TC, Wang LH, Huang KB, Kuo CT, Chao CH, Chang SJ, Hsu JM, Weng J, Ren N, Li FA, Lai YJ, Zhou C,
Hung MC
, Li CW. Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis. Am J Cancer Res. 2022; 12(10):4721-4736.
PMID:
36381324
; PMCID:
PMC9641385
.
Citations:
1
Li YC,
Yamaguchi H
, Liu YY, Hsu KC, Sun TH, Sun PC,
Hung MC
. Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1. Am J Cancer Res. 2022; 12(10):4865-4878.
PMID:
36381327
; PMCID:
PMC9641407
.
Citations:
1
Mei Y, Hang Q, Teng H, Yao F, Chen MK,
Hung MC
, Sun Y, Ma L. ZRANB1 is an NBS1 deubiquitinase and a potential target to overcome radioresistance and PARP inhibitor resistance in triple-negative breast cancer. Genes Dis. 2023 Sep; 10(5):1739-1742.
PMID:
37492703
; PMCID:
PMC10363626
.
Citations:
Zhou Q, Yin Y, Yu M, Gao D, Sun J, Yang Z, Weng J, Chen W, Atyah M, Shen Y, Ye Q, Li CW,
Hung MC
, Dong Q, Zhou C, Ren N. GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism. Redox Biol. 2022 10; 56:102458.
PMID:
36116159
; PMCID:
PMC9483790
.
Citations:
Lau P, Zhang G, Zhao S, Liang L, Zhang H, Zhou G,
Hung MC
, Chen X, Liu H. Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis. Cell Mol Immunol. 2022 10; 19(10):1153-1167.
PMID:
36050478
; PMCID:
PMC9508236
.
Citations:
Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Zeng GD, Wang F, Feng WX, Zheng J, Wang YN, Zeng B, Liu Q,
Hung MC
, Wan XB. DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0. Cell Death Dis. 2022 08 16; 13(8):709.
PMID:
35974014
; PMCID:
PMC9381602
.
Citations:
Ho CT, Lin SP, Tseng LM,
Hung MC
, Hung SC. Snail induces dormancy in disseminated luminal type A breast cancer through Src inhibition. Am J Cancer Res. 2022; 12(8):3932-3946.
PMID:
36119827
; PMCID:
PMC9442010
.
Citations:
Wang WJ, Chen Y, Su WC, Liu YY, Shen WJ, Chang WC, Huang ST, Lin CW, Wang YC, Yang CS, Hou MH, Chou YC, Wu YC, Wang SC,
Hung MC
. Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2. J Food Biochem. 2022 10; 46(10):e14354.
PMID:
35894128
; PMCID:
PMC9353385
.
Citations:
Fields:
Nut
Nutritional Sciences
Chen HF, Hsueh PR, Liu YY, Chen Y, Chang SY, Wang WJ, Wu CS, Tsai YM, Liu YS, Su WC, Chou YC,
Hung MC
. Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2. Am J Cancer Res. 2022; 12(7):3333-3346.
PMID:
35968340
; PMCID:
PMC9360250
.
Citations:
Wu CS, Chiang HM, Chen Y, Chen CY, Chen HF, Su WC, Wang WJ, Chou YC, Chang WC, Wang SC,
Hung MC
. Prospects of Coffee Leaf against SARS-CoV-2 Infection. Int J Biol Sci. 2022; 18(12):4677-4689.
PMID:
35874948
; PMCID:
PMC9305275
.
Citations:
Fields:
Bio
Biology
Translation:
Animals
Cells
Wang SC, Chou IW,
Hung MC
. Natural tannins as anti-SARS-CoV-2 compounds. Int J Biol Sci. 2022; 18(12):4669-4676.
PMID:
35874955
; PMCID:
PMC9305278
.
Citations:
Fields:
Bio
Biology
Translation:
Humans
Cells
PH
Public Health
Yen JH, Huang WC, Lin SC, Huang YW, Chio WT, Tsay GJ,
Hung MC
, Huang ST. Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis. Mol Ther Oncolytics. 2022 Sep 15; 26:158-174.
PMID:
35860009
; PMCID:
PMC9271981
.
Citations:
Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J,
Hung MC
,
Sood AK
. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2022 Jun 21; 39(12):110999.
PMID:
35732127
; PMCID:
PMC9272813
.
Citations:
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Hsieh RC,
Krishnan S
, Wu RC, Boda AR, Liu A, Winkler M, Hsu WH,
Lin SH
,
Hung MC
, Chan LC, Bhanu KR, Srinivasamani A, De Azevedo RA, Chou YC,
DePinho RA
, Gubin M, Vilar E, Chen CH, Slay R, Jayaprakash P, Hegde SM, Hartley G, Lea ST, Prasad R, Morrow B, Couillault CA, Steiner M, Wang CC, Venkatesulu BP,
Taniguchi C
, Kim YSB, Chen J, Rudqvist NP,
Curran MA
. ATR-mediated CD47 and PD-L1 up-regulation restricts radiotherapy-induced immune priming and abscopal responses in colorectal cancer. Sci Immunol. 2022 06 10; 7(72):eabl9330.
PMID:
35687697
; PMCID:
PMC9373855
.
Citations:
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Zhao X, Wei Y, Chu YY, Li Y, Hsu JM, Jiang Z, Liu C, Hsu JL, Chang WC,
Yang R
, Chan LC, Qu J, Zhang S,
Ying H
,
Yu D
,
Hung MC
. Phosphorylation and Stabilization of PD-L1 by CK2 Suppresses Dendritic Cell Function. Cancer Res. 2022 06 06; 82(11):2185-2195.
PMID:
35385574
.
Citations:
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Wu CS, Lu WH,
Hung MC
, Huang YS, Chao HW. From polyploidy to polyploidy reversal: its role in normal and disease states. Trends Genet. 2022 10; 38(10):991-995.
PMID:
35637074
.
Citations:
Fields:
Gen
Genetics
Xue Z, Zheng S, Linghu D, Liu B, Yang Y, Chen MK, Huang H, Song J, Li H, Wang J,
Hung MC
, Zhong D, Sun L. PD-L1 deficiency sensitizes tumor cells to DNA-PK inhibition and enhances cGAS-STING activation. Am J Cancer Res. 2022; 12(5):2363-2375.
PMID:
35693073
; PMCID:
PMC9185610
.
Citations:
Wang YL, Zhao WW, Bai SM, Feng LL, Bie SY, Gong L, Wang F, Wei MB, Feng WX, Pang XL, Qin CL, Yin XK, Wang YN, Zhou W, Wahl DR, Liu Q, Chen M,
Hung MC
, Wan XB. MRNIP condensates promote DNA double-strand break sensing and end resection. Nat Commun. 2022 05 12; 13(1):2638.
PMID:
35551189
; PMCID:
PMC9098523
.
Citations:
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Yamaguchi H
, Wang SC,
Hung MC
. Prospects of the potential strategies to improve the efficacy of anti-PD-1/PD-L1 therapy. Clin Transl Med. 2022 05; 12(5):e803.
PMID:
35588146
; PMCID:
PMC9119611
.
Citations:
1
Fields:
Bio
Biomedical Engineering
Med
Medicine (General)
Translation:
Humans
Liu C, Zha Z, Zhou C, Chen Y,
Xia W
, Wang YN, Lee HH, Yin Y, Yan M, Chang CW, Chan LC, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N,
Hung MC
. Erratum to 'Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma' [J Hepatol 2021 (907-918)]. J Hepatol. 2022 Aug; 77(2):580.
PMID:
35489965
.
Citations:
Fields:
Gas
Gastroenterology
Jabbarzadeh Kaboli P, Shabani S, Sharma S, Partovi Nasr M,
Yamaguchi H
,
Hung MC
. Shedding light on triple-negative breast cancer with Trop2-targeted antibody-drug conjugates. Am J Cancer Res. 2022; 12(4):1671-1685.
PMID:
35530278
; PMCID:
PMC9077081
.
Citations:
Chang LC, Chiang SK, Chen SE,
Hung MC
. Targeting 2-oxoglutarate dehydrogenase for cancer treatment. Am J Cancer Res. 2022; 12(4):1436-1455.
PMID:
35530286
; PMCID:
PMC9077069
.
Citations:
Tu J, Huo Z, Yu Y, Zhu D, Xu A, Huang MF, Hu R, Wang R, Gingold JA, Chen YH, Tsai KL, Forcioli-Conti NR, Huang SXL, Webb TR, Su J, Bazer DA, Jia P,
Yustein JT
,
Wang LL
,
Hung MC
, Zhao Z,
Huff CD
, Shen J, Zhao R, Lee DF. Hereditary retinoblastoma iPSC model reveals aberrant spliceosome function driving bone malignancies. Proc Natl Acad Sci U S A. 2022 04 19; 119(16):e2117857119.
PMID:
35412907
; PMCID:
PMC9169787
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Cells
Yang R
, Sun L, Li CF, Wang YH,
Xia W
, Liu B, Chu YY,
Bover L
, Vien L,
Hung MC
. Development and characterization of anti-galectin-9 antibodies that protect T cells from galectin-9-induced cell death. J Biol Chem. 2022 04; 298(4):101821.
PMID:
35283189
; PMCID:
PMC9006662
.
Citations:
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Cha JH, Chan LC, Wang YN, Chu YY, Wang CH, Lee HH,
Xia W
, Shyu WC, Liu SP,
Yao J
, Chang CW, Cheng FR, Liu J,
Lim SO
, Hsu JL, Yang WH, Hortobagyi GN, Lin C, Yang L,
Yu D
, Jeng LB,
Hung MC
. Ephrin receptor A10 monoclonal antibodies and the derived chimeric antigen receptor T cells exert an antitumor response in mouse models of triple-negative breast cancer. J Biol Chem. 2022 04; 298(4):101817.
PMID:
35278434
; PMCID:
PMC8988001
.
Citations:
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Wang YN, Lee HH, Wei Y, Chu YY,
Xia W
, Wang M,
Yu D
,
Hung MC
. An optimized protocol for PD-L1 pathological assessment with patient sample deglycosylation to improve correlation with therapeutic response. STAR Protoc. 2022 03 18; 3(1):101198.
PMID:
35243381
; PMCID:
PMC8885744
.
Citations:
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Zhou C, Weng J, Gao Y, Liu C, Zhu X, Zhou Q, Li CW, Sun J, Atyah M, Yi Y, Ye Q, Shi Y, Dong Q, Liu Y,
Hung MC
, Ren N. A Novel mRNA Signature Related to Immunity to Predict Survival and Immunotherapy Response in Hepatocellular Carcinoma. J Clin Transl Hepatol. 2022 Oct 28; 10(5):925-938.
PMID:
36304510
; PMCID:
PMC9547263
.
Citations:
Yu M, Chen Z, Zhou Q, Zhang B, Huang J, Jin L, Zhou B, Liu S, Yan J, Li X, Zhang W, Liu C, Hu B, Fu P, Zhou C, Xu Y, Xiao Y, Zhou J, Fan J, Ren N,
Hung MC
, Guo L, Li H, Ye Q. PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy. J Hepatol. 2022 07; 77(1):140-151.
PMID:
35157958
.
Citations:
1
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Cells
Yamaguchi H
, Hsu JM, Yang WH,
Hung MC
. Mechanisms regulating PD-L1 expression in cancers and associated opportunities for novel small-molecule therapeutics. Nat Rev Clin Oncol. 2022 05; 19(5):287-305.
PMID:
35132224
.
Citations:
2
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Chen Y, Yang WH, Chen HF, Huang LM, Gao JY, Lin CW, Wang YC, Yang CS, Liu YL, Hou MH, Tsai CL, Chou YZ, Huang BY, Hung CF, Hung YL, Wang WJ, Su WC, Kumar V, Wu YC, Chao SW, Chang CS, Chen JS, Chiang YP, Cho DY, Jeng LB, Tsai CH,
Hung MC
. Tafenoquine and its derivatives as inhibitors for the severe acute respiratory syndrome coronavirus 2. J Biol Chem. 2022 03; 298(3):101658.
PMID:
35101449
; PMCID:
PMC8800562
.
Citations:
1
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
PH
Public Health
Wen Y
, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J,
Hung MC
,
Sood AK
. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2022 01 25; 38(4):110301.
PMID:
35081345
; PMCID:
PMC8860355
.
Citations:
1
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Ou-Yang F, Li CL, Chen CC, Shen YC, Moi SH, Luo CW, Xia WY, Wang YN, Lee HH, Wang LH, Wang SC, Pan MR, Hou MF,
Hung MC
. De-glycosylated membrane PD-L1 in tumor tissues as a biomarker for responsiveness to atezolizumab (Tecentriq) in advanced breast cancer patients. Am J Cancer Res. 2022; 12(1):123-137.
PMID:
35141008
; PMCID:
PMC8822291
.
Citations:
3
Shih DJH, Chen MK, Yin J, McGrail DJ, Dai H, Wei R, Zhang J, Zheng WJ,
Do KA
, Yang L,
Hung MC
,
Lin SY
. Exploiting induced vulnerability to overcome PARPi resistance and clonal heterogeneity in BRCA mutant triple-negative inflammatory breast cancer. Am J Cancer Res. 2022; 12(1):337-354.
PMID:
35141022
; PMCID:
PMC8822293
.
Citations:
Chu CS, Yang CY, Yeh CC, Lin RT, Chen CC, Bai LY,
Hung MC
, Lin CC, Wu CY, Lin JT. Endoscopic ultrasound-guided fine-needle biopsy as a tool for studying the intra-tumoral microbiome in pancreatic ductal adenocarcinoma: a pilot study. Sci Rep. 2022 01 07; 12(1):107.
PMID:
34997106
; PMCID:
PMC8741880
.
Citations:
Fields:
Sci
Science
Translation:
Humans
Cells
Feng L, Liu Z, Li C, Li Z, Lou X, Shao L, Wang Y, Huang Y, Chen H, Pang X, Liu S, He F, Zheng J, Meng X, Xie P, Yang G, Ding Y, Wei M, Yun J,
Hung MC
, Zhou W, Wahl DR, Lan P, Tian J, Wan X. Development and validation of a radiopathomics model to predict pathological complete response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer: a multicentre observational study. Lancet Digit Health. 2022 01; 4(1):e8-e17.
PMID:
34952679
.
Citations:
3
Fields:
Med
Medical Informatics
Pub
Public Health
Translation:
Humans
Sun LL, Linghu DL,
Hung MC
. Ferroptosis: a promising target for cancer immunotherapy. Am J Cancer Res. 2021; 11(12):5856-5863.
PMID:
35018229
; PMCID:
PMC8727800
.
Citations:
4
Deng Y, Xia X, Zhao Y, Zhao Z, Martinez C, Yin W,
Yao J
, Hang Q, Wu W, Zhang J, Yu Y,
Xia W
, Yao F, Zhao D, Sun Y,
Ying H
,
Hung MC
, Ma L. Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance. Nat Commun. 2021 12 06; 12(1):7041.
PMID:
34873175
; PMCID:
PMC8649069
.
Citations:
1
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Hou J, Hsu JM,
Hung MC
. Molecular mechanisms and functions of pyroptosis in inflammation and antitumor immunity. Mol Cell. 2021 11 18; 81(22):4579-4590.
PMID:
34562371
; PMCID:
PMC8604761
.
Citations:
14
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Chen GY, Pan YC, Wu TY, Yao TY, Wang WJ, Shen WJ, Ahmed A, Chan ST, Tang CH, Huang WC,
Hung MC
, Yang JC, Wu YC. Potential natural products that target the SARS-CoV-2 spike protein identified by structure-based virtual screening, isothermal titration calorimetry and lentivirus particles pseudotyped (Vpp) infection assay. J Tradit Complement Med. 2022 Jan; 12(1):73-89.
PMID:
34549024
; PMCID:
PMC8443859
.
Citations:
1
Lin YZ, Lee CC, Cho DY, Wang YL, Chen CY, Weng CY, Chiu SC,
Hung MC
, Wang SC. Suppression of breast cancer cells resistant to a pure anti-estrogen with CAR-transduced natural killer cells. Am J Cancer Res. 2021; 11(9):4455-4469.
PMID:
34659898
; PMCID:
PMC8493389
.
Citations:
1
Li Y, Zhang Y, Hu Q, Egranov SD, Xing Z, Zhang Z, Liang K, Ye Y, Pan Y, Chatterjee SS, Mistretta B, Nguyen TK, Hawke DH,
Gunaratne PH
,
Hung MC
, Han L, Yang L, Lin C. Functional significance of gain-of-function H19 lncRNA in skeletal muscle differentiation and anti-obesity effects. Genome Med. 2021 08 28; 13(1):137.
PMID:
34454586
; PMCID:
PMC8403366
.
Citations:
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Wang YL, Lee CC, Shen YC, Lin PL, Wu WR, Lin YZ, Cheng WC, Chang H, Hung Y, Cho YC, Liu LC, Xia WY, Ji JH, Liang JA, Chiang SF, Liu CG, Yao J,
Hung MC
, Wang SC. Evading immune surveillance via tyrosine phosphorylation of nuclear PCNA. Cell Rep. 2021 08 24; 36(8):109537.
PMID:
34433039
.
Citations:
2
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Liu J, Yuan B, Cao J, Luo H, Gu S, Zhang M, Ding R, Zhang L, Zhou F,
Hung MC
, Xu P, Lin X, Jin J, Feng XH. AMBRA1 Promotes TGF? Signaling via Nonproteolytic Polyubiquitylation of Smad4. Cancer Res. 2021 10 01; 81(19):5007-5020.
PMID:
34362797
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Li Y,
Tan Z
, Zhang Y, Zhang Z, Hu Q, Liang K, Jun Y, Ye Y, Li YC, Li C,
Liao L
, Xu J, Xing Z, Pan Y, Chatterjee SS, Nguyen TK, Hsiao H, Egranov SD,
Putluri N
,
Coarfa C
, Hawke DH,
Gunaratne PH
, Tsai KL, Han L,
Hung MC
,
Calin GA
, Namour F, Muntau AC, Blau N,
Sutton VR
, Zhang S, Lin C, Yang L, Gu?ant JL, Schiff M, Feillet F. A noncoding RNA modulator potentiates phenylalanine metabolism in mice. Science. 2021 08 06; 373(6555):662-673.
PMID:
34353949
; PMCID:
PMC9714245
.
Citations:
5
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Lin YZ, Shen YC, Wu WR, Wang WJ, Wang YL, Lin CY,
Hung MC
, Wang SC. Imatinib (STI571) Inhibits the Expression of Angiotensin-Converting Enzyme 2 and Cell Entry of the SARS-CoV-2-Derived Pseudotyped Viral Particles. Int J Mol Sci. 2021 Jun 28; 22(13).
PMID:
34203261
; PMCID:
PMC8268654
.
Citations:
3
Fields:
Bio
Biochemistry
Che
Chemistry
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Qiu Y, Yang Y,
Yang R
, Liu C, Hsu JM, Jiang Z, Sun L, Wei Y, Li CW, Yu D, Zhang J,
Hung MC
. Activated T cell-derived exosomal PD-1 attenuates PD-L1-induced immune dysfunction in triple-negative breast cancer. Oncogene. 2021 08; 40(31):4992-5001.
PMID:
34172932
; PMCID:
PMC8342306
.
Citations:
13
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen CH, Wang BW, Hsiao YC, Wu CY, Cheng FJ, Hsia TC, Chen CY, Wang Y, Weihua Z, Chou RH, Tang CH, Chen YJ, Wei YL, Hsu JL, Tu CY,
Hung MC
, Huang WC. PKCd-mediated SGLT1 upregulation confers the acquired resistance of NSCLC to EGFR TKIs. Oncogene. 2021 Jul; 40(29):4796-4808.
PMID:
34155348
; PMCID:
PMC8298203
.
Citations:
2
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Cells
Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Liu D, Bai X, Sun B,
Hung MC
, Liu L, Wands JR, Dong X. Multi-organ metastasis as destination for breast cancer cells guided by biomechanical architecture. Am J Cancer Res. 2021; 11(6):2537-2567.
PMID:
34249415
; PMCID:
PMC8263653
.
Citations:
1
Fan XJ, Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Feng WX, Wang YN, Liu Q,
Hung MC
, Wan XB. NONO phase separation enhances DNA damage repair by accelerating nuclear EGFR-induced DNA-PK activation. Am J Cancer Res. 2021; 11(6):2838-2852.
PMID:
34249431
; PMCID:
PMC8263645
.
Citations:
Lin YX,
Hung MC
, Hsu JL, Hsu JM. The N-linked glycosylations of TIGIT Asn32 and Asn101 facilitate PVR/TIGIT interaction. Biochem Biophys Res Commun. 2021 07 12; 562:9-14.
PMID:
34030043
.
Citations:
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Cells
Wang YL, Wei MB, Zhao WW, Feng LL, Yin XK, Bai SM, Wan XB,
Hung MC
, Zou AZ, Wang MH, Zheng J, Qin C, Fan XJ. Glycosylation of Siglec15 promotes immunoescape and tumor growth. Am J Cancer Res. 2021; 11(5):2291-2302.
PMID:
34094685
; PMCID:
PMC8167674
.
Citations:
Lee HH, Wang YN, Yang WH,
Xia W
, Wei Y, Chan LC, Wang YH, Jiang Z, Xu S,
Yao J
, Qiu Y, Hsu YH, Hwang WL, Yan M, Cha JH, Hsu JL, Shen J,
Ye Y
, Wu X, Hou MF, Tseng LM, Wang SC, Pan MR, Yang CH, Wang YL,
Yamaguchi H
, Pang D, Hortobagyi GN,
Yu D
,
Hung MC
. Human ribonuclease 1 serves as a secretory ligand of ephrin A4 receptor and induces breast tumor initiation. Nat Commun. 2021 05 13; 12(1):2788.
PMID:
33986289
; PMCID:
PMC8119676
.
Citations:
3
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Huang ST, Chen Y, Chang WC, Chen HF, Lai HC, Lin YC, Wang WJ, Wang YC, Yang CS, Wang SC,
Hung MC
. Scutellaria barbata D. Don Inhibits the Main Proteases (Mpro and TMPRSS2) of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Infection. Viruses. 2021 05 02; 13(5).
PMID:
34063247
; PMCID:
PMC8147405
.
Citations:
5
Fields:
Vir
Virology
Translation:
Humans
Animals
Cells
PH
Public Health
Dai X, Bu X, Gao Y, Guo J, Hu J, Jiang C, Zhang Z, Xu K, Duan J, He S, Zhang J, Wan L, Liu T, Zhou X,
Hung MC
, Freeman GJ, Wei W. Energy status dictates PD-L1 protein abundance and anti-tumor immunity to enable checkpoint blockade. Mol Cell. 2021 06 03; 81(11):2317-2331.e6.
PMID:
33909988
; PMCID:
PMC8178223
.
Citations:
16
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Jiang Z,
Lim SO
, Yan M, Hsu JL,
Yao J
, Wei Y, Chang SS,
Yamaguchi H
, Lee HH, Ke B, Hsu JM, Chan LC, Hortobagyi GN, Yang L, Lin C,
Yu D
,
Hung MC
. TYRO3 induces anti-PD-1/PD-L1 therapy resistance by limiting innate immunity and tumoral ferroptosis. J Clin Invest. 2021 04 15; 131(8).
PMID:
33855973
; PMCID:
PMC8262501
.
Citations:
16
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Chen Y, Huang WC, Yang CS, Cheng FJ, Chiu YF, Chen HF, Huynh TK, Huang CF, Chen CH, Wang HC,
Hung MC
. Screening strategy of TMPRSS2 inhibitors by FRET-based enzymatic activity for TMPRSS2-based cancer and COVID-19 treatment. Am J Cancer Res. 2021; 11(3):827-836.
PMID:
33791156
; PMCID:
PMC7994159
.
Citations:
2
Yang R
, Sun L, Li CF, Wang YH,
Yao J
, Li H, Yan M, Chang WC, Hsu JM, Cha JH, Hsu JL, Chou CW, Sun X, Deng Y,
Chou CK
,
Yu D
,
Hung MC
. Galectin-9 interacts with PD-1 and TIM-3 to regulate T cell death and is a target for cancer immunotherapy. Nat Commun. 2021 02 05; 12(1):832.
PMID:
33547304
; PMCID:
PMC7864927
.
Citations:
46
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Yin XK, Wang YL, Wang F, Feng WX, Bai SM, Zhao WW, Feng LL, Wei MB, Qin CL, Wang F, Chen ZL, Yi HJ, Huang Y, Xie PY, Kim T, Wang YN, Hou JW, Li CW, Liu Q, Fan XJ,
Hung MC
, Wan XB. PRMT1 enhances oncogenic arginine methylation of NONO in colorectal cancer. Oncogene. 2021 02; 40(7):1375-1389.
PMID:
33420374
; PMCID:
PMC7892343
.
Citations:
7
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Cho J, Min HY, Lee HJ, Hyun SY, Sim JY, Noh M, Hwang SJ, Park SH, Boo HJ, Lee HJ, Hong S, Park RW, Shin YK,
Hung MC
, Lee HY. RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. J Clin Invest. 2021 01 04; 131(1).
PMID:
33393490
; PMCID:
PMC7773398
.
Citations:
6
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Gao Y, Chen MK, Chu YY, Yang L, Yu D, Liu Y,
Hung MC
. Nuclear translocation of the receptor tyrosine kinase c-MET reduces the treatment efficacies of olaparib and gemcitabine in pancreatic ductal adenocarcinoma cells. Am J Cancer Res. 2021; 11(1):236-250.
PMID:
33520371
; PMCID:
PMC7840709
.
Citations:
3
Cheng FJ, Chen CH, Tsai WC, Wang BW, Yu MC, Hsia TC, Wei YL, Hsiao YC, Hu DW, Ho CY, Li TS, Wu CY, Chou WY, Yu YL, Tang CH, Chen CY, Chen CM, Hsu JL, Chen HF, Chen Y, Tu CY,
Hung MC
, Huang WC. Cigarette smoke-induced LKB1/AMPK pathway deficiency reduces EGFR TKI sensitivity in NSCLC. Oncogene. 2021 02; 40(6):1162-1175.
PMID:
33335306
; PMCID:
PMC7878190
.
Citations:
2
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Wang SC, Chen Y, Wang YC, Wang WJ, Yang CS, Tsai CL, Hou MH, Chen HF, Shen YC,
Hung MC
. Tannic acid suppresses SARS-CoV-2 as a dual inhibitor of the viral main protease and the cellular TMPRSS2 protease. Am J Cancer Res. 2020; 10(12):4538-4546.
PMID:
33415017
; PMCID:
PMC7783773
.
Citations:
21
Li H, Kuang X, Liang L, Ye Y, Zhang Y, Li J, Ma F, Tao J, Lei G, Zhao S, Su J, Yang N, Peng C, Xu X,
Hung MC
, Han L, Liu H, Liu J, Chen X. The Beneficial Role of Sunitinib in Tumor Immune Surveillance by Regulating Tumor PD-L1. Adv Sci (Weinh). 2021 Jan; 8(2):2001596.
PMID:
33510997
; PMCID:
PMC7816704
.
Citations:
14
Fields:
Bio
Biomedical Engineering
Sun HL, Zhu AC, Gao Y, Terajima H, Fei Q, Liu S, Zhang L, Zhang Z, Harada BT, He YY, Bissonnette MB,
Hung MC
, He C. Stabilization of ERK-Phosphorylated METTL3 by USP5 Increases m6A Methylation. Mol Cell. 2020 11 19; 80(4):633-647.e7.
PMID:
33217317
; PMCID:
PMC7720844
.
Citations:
13
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Hou J, Zhao R,
Xia W
, Chang CW, You Y, Hsu JM,
Nie L
, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B,
Tainer JA
,
Hung MC
. Author Correction: PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol. 2020 Nov; 22(11):1396.
PMID:
33033376
.
Citations:
4
Fields:
Cel
Cell Biology
Zhang Y, Li Y, Hu Q, Xi Y, Xing Z, Zhang Z, Huang L, Wu J, Liang K, Nguyen TK, Egranov SD, Sun C, Zhao Z, Hawke DH, Li J, Sun D, Kim JJ, Zhang P,
Cheng J
, Farida A,
Hung MC
, Han L, Darabi R, Lin C, Yang L. The lncRNA H19 alleviates muscular dystrophy by stabilizing dystrophin. Nat Cell Biol. 2020 11; 22(11):1332-1345.
PMID:
33106653
; PMCID:
PMC7951180
.
Citations:
21
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Liu C, Zha Z, Zhou C, Chen Y,
Xia W
, Wang YN, Lee HH, Yin Y, Yan M, Chang CW, Chan LC, Qiu Y, Li H, Li CW, Hsu JM, Hsu JL, Wang SC, Ren N,
Hung MC
. Ribonuclease 7-driven activation of ROS1 is a potential therapeutic target in hepatocellular carcinoma. J Hepatol. 2021 04; 74(4):907-918.
PMID:
33031845
; PMCID:
PMC7979498
.
Citations:
5
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Ai D,
Yao J
, Yang F,
Huo L
, Chen H, Lu W, Soto LMS, Jiang M, Raso MG, Wang S,
Bell D
, Liu J, Wang H,
Tan D
, Torres-Cabala C, Gan Q, Wu Y,
Albarracin C
,
Hung MC
,
Meric-Bernstam F
,
Wistuba II
,
Prieto VG
,
Sahin AA
, Ding Q. TRPS1: a highly sensitive and specific marker for breast carcinoma, especially for triple-negative breast cancer. Mod Pathol. 2021 04; 34(4):710-719.
PMID:
33011748
.
Citations:
4
Fields:
Pat
Pathology
Translation:
Humans
Chou CW, Yang RY, Chan LC, Li CF, Sun L, Lee HH, Lee PC, Sher YP, Ying H,
Hung MC
. Erratum: The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Am J Cancer Res. 2020; 10(10):3507.
PMID:
33163286
; PMCID:
PMC7642660
.
Citations:
Song X, Zhou Z, Li H, Xue Y, Lu X, Bahar I,
Hung MC
, Wan Y, Kepp O, Kroemer G. Pharmacologic Suppression of B7-H4 Glycosylation Restores Antitumor Immunity in Immune-Cold Breast Cancers. Cancer Discov. 2020 12; 10(12):1872-1893.
PMID:
32938586
; PMCID:
PMC7710601
.
Citations:
17
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Hou J, Zhao R,
Xia W
, Chang CW, You Y, Hsu JM,
Nie L
, Chen Y, Wang YC, Liu C, Wang WJ, Wu Y, Ke B, Hsu JL, Huang K, Ye Z, Yang Y, Xia X, Li Y, Li CW, Shao B,
Tainer JA
,
Hung MC
. PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis. Nat Cell Biol. 2020 10; 22(10):1264-1275.
PMID:
32929201
; PMCID:
PMC7653546
.
Citations:
134
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Zhou C, Weng J, Liu C, Zhou Q, Chen W, Hsu JL, Sun J, Atyah M, Xu Y, Shi Y, Shen Y, Dong Q,
Hung MC
, Ren N. High RPS3A expression correlates with low tumor immune cell infiltration and unfavorable prognosis in hepatocellular carcinoma patients. Am J Cancer Res. 2020; 10(9):2768-2784.
PMID:
33042616
; PMCID:
PMC7539769
.
Citations:
6
Lin CC, Huang YK, Cho CF, Lin YS, Lo CC, Kuo TT, Tseng GC, Cheng WC, Chang WC, Hsiao TH, Lai LC, Shih JY, Liu YH, Chao KSC, Hsu JL, Lee PC, Sun X,
Hung MC
, Sher YP. Targeting positive feedback between BASP1 and EGFR as a therapeutic strategy for lung cancer progression. Theranostics. 2020; 10(24):10925-10939.
PMID:
33042262
; PMCID:
PMC7532684
.
Citations:
4
Fields:
Dia
Diagnostic Imaging
Mol
Molecular Biology
Nan
Nanotechnology
The
Therapeutics
Translation:
Humans
Animals
Cells
Cha JH, Chan LC, Song MS,
Hung MC
. New Approaches on Cancer Immunotherapy. Cold Spring Harb Perspect Med. 2020 08 03; 10(8).
PMID:
31615865
; PMCID:
PMC7156317
.
Citations:
1
Fields:
Med
Medicine (General)
Wang YC, Yang WH, Yang CS, Hou MH, Tsai CL, Chou YZ,
Hung MC
, Chen Y. Structural basis of SARS-CoV-2 main protease inhibition by a broad-spectrum anti-coronaviral drug. Am J Cancer Res. 2020; 10(8):2535-2545.
PMID:
32905393
; PMCID:
PMC7471349
.
Citations:
23
Chou CW, Yang RY, Chan LC, Li CF, Sun L, Lee HH, Lee PC, Sher YP, Ying H,
Hung MC
. The stabilization of PD-L1 by the endoplasmic reticulum stress protein GRP78 in triple-negative breast cancer. Am J Cancer Res. 2020; 10(8):2621-2634.
PMID:
32905506
; PMCID:
PMC7471351
.
Citations:
9
Jiang Z, Hsu JL, Li Y, Hortobagyi GN,
Hung MC
. Cancer Cell Metabolism Bolsters Immunotherapy Resistance by Promoting an Immunosuppressive Tumor Microenvironment. Front Oncol. 2020; 10:1197.
PMID:
32775303
; PMCID:
PMC7387712
.
Citations:
9
Wang YN, Lee HH, Hsu JL,
Yu D
,
Hung MC
. The impact of PD-L1?N-linked glycosylation on cancer therapy and clinical diagnosis. J Biomed Sci. 2020 Jul 03; 27(1):77.
PMID:
32620165
; PMCID:
PMC7333976
.
Citations:
30
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Huang ST, Lai HC, Lin YC, Huang WT, Hung HH, Ou SC, Lin HJ,
Hung MC
. Principles and treatment strategies for the use of Chinese herbal medicine in patients at different stages of coronavirus infection. Am J Cancer Res. 2020; 10(7):2010-2031.
PMID:
32774998
; PMCID:
PMC7407358
.
Citations:
9
Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH,
Hung MC
, Sarbassov D, Lin HK. Author Correction: A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1a activation, tumorigenesis and metastasis. Nat Cell Biol. 2020 Jul; 22(7):907.
PMID:
32504031
.
Citations:
Fields:
Cel
Cell Biology
Chen MK, Hsu JL,
Hung MC
. Nuclear receptor tyrosine kinase transport and functions in cancer. Adv Cancer Res. 2020; 147:59-107.
PMID:
32593407
.
Citations:
7
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Zhang L,
Yao J
, Wei Y, Zhou Z, Li P, Qu J, Badu-Nkansah A, Yuan X, Huang YW, Fukumura K, Mao X, Chang WC, Saunus J, Lakhani S,
Huse JT
,
Hung MC
,
Yu D
. Blocking immunosuppressive neutrophils deters pY696-EZH2-driven brain metastases. Sci Transl Med. 2020 05 27; 12(545).
PMID:
32461334
; PMCID:
PMC7948522
.
Citations:
21
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Zhou B, Yan J, Guo L, Zhang B, Liu S, Yu M, Chen Z, Zhang K, Zhang W, Li X, Xu Y, Xiao Y, Zhou J, Fan J,
Hung MC
, Li H, Ye Q. Hepatoma cell-intrinsic TLR9 activation induces immune escape through PD-L1 upregulation in hepatocellular carcinoma. Theranostics. 2020; 10(14):6530-6543.
PMID:
32483468
; PMCID:
PMC7255037
.
Citations:
11
Fields:
Dia
Diagnostic Imaging
Mol
Molecular Biology
Nan
Nanotechnology
The
Therapeutics
Translation:
Humans
Animals
Cells
Xu D, Wang Z, Xia Y, Shao F, Xia W, Wei Y, Li X, Qian X, Lee JH, Du L, Zheng Y, Lv G, Leu JS, Wang H, Xing D, Liang T,
Hung MC
, Lu Z. The gluconeogenic enzyme PCK1 phosphorylates INSIG1/2 for lipogenesis. Nature. 2020 04; 580(7804):530-535.
PMID:
32322062
.
Citations:
42
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Han Y, Wei Y, Yao J, Chu YY, Li CW, Hsu JL,
Nie L
,
Hung MC
. Inhibition of CDK2 reduces EZH2 phosphorylation and reactivates ERa expression in high-grade serous ovarian carcinoma. Am J Cancer Res. 2020; 10(4):1194-1206.
PMID:
32368395
; PMCID:
PMC7191104
.
Citations:
5
Zhou C, Liu C, Liu W, Chen W, Yin Y, Li CW, Hsu JL, Sun J, Zhou Q, Li H, Hu B, Fu P, Atyah M, Ma Q, Xu Y, Dong Q,
Hung MC
, Ren N. SLFN11 inhibits hepatocellular carcinoma tumorigenesis and metastasis by targeting RPS4X via mTOR pathway. Theranostics. 2020; 10(10):4627-4643.
PMID:
32292519
; PMCID:
PMC7150495
.
Citations:
28
Fields:
Dia
Diagnostic Imaging
Mol
Molecular Biology
Nan
Nanotechnology
The
Therapeutics
Translation:
Humans
Animals
Cells
Liu H, Kuang X, Zhang Y, Ye Y, Li J, Liang L, Xie Z, Weng L, Guo J, Li H, Ma F, Chen X, Zhao S, Su J, Yang N, Fang F, Xie Y, Tao J, Zhang J, Chen M, Peng C, Sun L, Zhang X, Liu J, Han L, Xu X,
Hung MC
, Chen X. ADORA1 Inhibition Promotes Tumor Immune Evasion by Regulating the ATF3-PD-L1 Axis. Cancer Cell. 2020 03 16; 37(3):324-339.e8.
PMID:
32183950
.
Citations:
34
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Sun L, Li CW, Chung EM,
Yang R
, Kim YS, Park AH, Lai YJ, Yang Y, Wang YH, Liu J, Qiu Y, Khoo KH, Yao J, Hsu JL, Cha JH, Chan LC, Hsu JM, Lee HH, Yoo SS,
Hung MC
. Targeting Glycosylated PD-1 Induces Potent Antitumor Immunity. Cancer Res. 2020 06 01; 80(11):2298-2310.
PMID:
32156778
; PMCID:
PMC7272274
.
Citations:
27
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chou CK
, Liu YL, Chen YI, Huang PJ, Tsou PH, Chen CT, Lee HH, Wang YN, Hsu JL, Lee JF, Yankeelov TE, Kameoka J, Yeh HC,
Hung MC
. Digital Receptor Occupancy Assay in Quantifying On- and Off-Target Binding Affinities of Therapeutic Antibodies. ACS Sens. 2020 02 28; 5(2):296-302.
PMID:
32073836
; PMCID:
PMC7093205
.
Citations:
Fields:
Bio
Biotechnology
Che
Chemistry Techniques
Translation:
Humans
Animals
Sun X, Li CW, Wang WJ, Chen MK, Li H, Lai YJ, Hsu JL, Koller PB, Chan LC, Lee PC, Cheng FJ, Yam C, Chen GY,
Hung MC
. Inhibition of c-MET upregulates PD-L1 expression in lung adenocarcinoma. Am J Cancer Res. 2020; 10(2):564-571.
PMID:
32195027
; PMCID:
PMC7061748
.
Citations:
5
Chu YY, Yam C, Chen MK, Chan LC, Xiao M, Wei YK,
Yamaguchi H
, Lee PC, Han Y,
Nie L
, Sun X,
Moulder SL
,
Hess KR
, Wang B, Hsu JL, Hortobagyi GN,
Litton J
, Chang JT,
Hung MC
. Blocking c-Met and EGFR reverses acquired resistance of PARP inhibitors in triple-negative breast cancer. Am J Cancer Res. 2020; 10(2):648-661.
PMID:
32195033
; PMCID:
PMC7061756
.
Citations:
17
Nie L
, Wei Y, Zhang F, Hsu YH, Chan LC,
Xia W
, Ke B, Zhu C, Deng R, Tang J,
Yao J
, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC,
Yamaguchi H
, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN,
Hung MC
. Author Correction: CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun. 2020 Jan 29; 11(1):673.
PMID:
31996688
; PMCID:
PMC6989459
.
Citations:
1
Fields:
Bio
Biology
Sci
Science
Chen HY, Wang ML, Laurent B, Hsu CH, Chen MT, Lin LT, Shen J, Chang WC, Hsu J,
Hung MC
, Chen YW, Huang PI, Yang YP, Li CP, Ma HI, Chen CH, Lin WC, Chiou SH. Musashi-1 promotes stress-induced tumor progression through recruitment of AGO2. Theranostics. 2020; 10(1):201-217.
PMID:
31903115
; PMCID:
PMC6929620
.
Citations:
6
Fields:
Dia
Diagnostic Imaging
Mol
Molecular Biology
Nan
Nanotechnology
The
Therapeutics
Translation:
Humans
Animals
Cells
Yen YT, Chien M, Lai YC, Chen DP, Chuong CM,
Hung MC
, Hung SC. PP2A Deficiency Enhances Carcinogenesis of Lgr5+ Intestinal Stem Cells Both in Organoids and In Vivo. Cells. 2019 Dec 30; 9(1).
PMID:
31905853
; PMCID:
PMC7017129
.
Citations:
3
Fields:
Bio
Biophysics
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Animals
Cells
Houl JH, Ye Z, Brosey CA, Balapiti-Modarage LPF, Namjoshi S, Bacolla A, Laverty D, Walker BL, Pourfarjam Y, Warden LS, Babu Chinnam N, Moiani D, Stegeman RA, Chen MK,
Hung MC
, Nagel ZD, Ellenberger T, Kim IK, Jones DE,
Ahmed Z
,
Tainer JA
. Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death. Nat Commun. 2019 12 11; 10(1):5654.
PMID:
31827085
; PMCID:
PMC6906431
.
Citations:
39
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Saab S, Chang OS, Nagaoka K,
Hung MC
,
Yamaguchi H
. The potential role of YAP in Axl-mediated resistance to EGFR tyrosine kinase inhibitors. Am J Cancer Res. 2019; 9(12):2719-2729.
PMID:
31911857
; PMCID:
PMC6943358
.
Citations:
5
McCleary-Wheeler AL, Carr RM, Palmer SR, Smyrk TC, Allred JB, Almada LL, Tolosa EJ, Lamberti MJ, Marks DL, Borad MJ, Molina JR, Qi Y, Lingle WL, Grothey A, Pitot HC, Jatoi A, Northfelt DW, Bryce AH, McWilliams RR, Okuno SH, Haluska P, Kim GP, Colon-Otero G, Lowe VJ, Callstrom MR, Ma WW, Bekaii-Saab T,
Hung MC
, Erlichman C, Fernandez-Zapico ME. Phase 1 trial of Vismodegib and Erlotinib combination in metastatic pancreatic cancer. Pancreatology. 2020 Jan; 20(1):101-109.
PMID:
31787526
; PMCID:
PMC7195700
.
Citations:
6
Fields:
End
Endocrinology
Gas
Gastroenterology
Translation:
Humans
CT
Clinical Trials
Nie L
, Wei Y, Zhang F, Hsu YH, Chan LC,
Xia W
, Ke B, Zhu C, Deng R, Tang J,
Yao J
, Chu YY, Zhao X, Han Y, Hou J, Huo L, Ko HW, Lin WC,
Yamaguchi H
, Hsu JM, Yang Y, Pan DN, Hsu JL, Kleer CG, Davidson NE, Hortobagyi GN,
Hung MC
. CDK2-mediated site-specific phosphorylation of EZH2 drives and maintains triple-negative breast cancer. Nat Commun. 2019 11 08; 10(1):5114.
PMID:
31704972
; PMCID:
PMC6841924
.
Citations:
26
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Lin Q, Chen X, Meng F, Ogawa K, Li M, Song R, Zhang S, Zhang Z, Kong X, Xu Q, He F, Bai X, Sun B,
Hung MC
, Liu L, Wands J, Dong X. ASPH-notch Axis guided Exosomal delivery of Prometastatic Secretome renders breast Cancer multi-organ metastasis. Mol Cancer. 2019 11 07; 18(1):156.
PMID:
31694640
; PMCID:
PMC6836474
.
Citations:
29
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Cha JH, Chan LC, Li CW, Hsu JL,
Hung MC
. Mechanisms Controlling PD-L1 Expression in Cancer. Mol Cell. 2019 11 07; 76(3):359-370.
PMID:
31668929
; PMCID:
PMC6981282
.
Citations:
138
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Wu X, Park M, Sarbassova DA,
Ying H
, Lee MG,
Bhattacharya R
,
Ellis L
, Peterson CB,
Hung MC
, Lin HK, Bersimbaev RI, Song MS,
Sarbassov DD
. A chirality-dependent action of vitamin C in suppressing Kirsten rat sarcoma mutant tumor growth by the oxidative combination: Rationale for cancer therapeutics. Int J Cancer. 2020 05 15; 146(10):2822-2828.
PMID:
31472018
; PMCID:
PMC7365556
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Li N, Wang Y, Neri S, Zhen Y, Fong LWR, Qiao Y, Li X, Chen Z, Stephan C, Deng W, Ye R, Jiang W, Zhang S, Yu Y,
Hung MC
, Chen J,
Lin SH
. Tankyrase disrupts metabolic homeostasis and promotes tumorigenesis by inhibiting LKB1-AMPK signalling. Nat Commun. 2019 09 25; 10(1):4363.
PMID:
31554794
; PMCID:
PMC6761205
.
Citations:
23
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Pataer A
,
Ozpolat B
, Shao R, Cashman NR, Plotkin SS, Samuel CE,
Lin SH
, Kabil NN, Wang J, Majidi M,
Fang B
,
Roth JA
,
Vaporciyan AA
,
Wistuba II
,
Hung MC
,
Swisher SG
. Therapeutic targeting of the PI4K2A/PKR lysosome network is critical for misfolded protein clearance and survival in cancer cells. Oncogene. 2020 01; 39(4):801-813.
PMID:
31554935
; PMCID:
PMC6976521
.
Citations:
5
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen FY, Huang MY, Lin YM, Ho CH, Lin SY, Chen HY,
Hung MC
, Chen RH. BIK ubiquitination by the E3 ligase Cul5-ASB11 determines cell fate during cellular stress. J Cell Biol. 2019 09 02; 218(9):3002-3018.
PMID:
31387940
; PMCID:
PMC6719446
.
Citations:
4
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Lee HH, Wang YN,
Xia W
, Chen CH, Rau KM, Ye L, Wei Y,
Chou CK
, Wang SC, Yan M, Tu CY, Hsia TC, Chiang SF, Chao KSC,
Wistuba II
, Hsu JL, Hortobagyi GN,
Hung MC
. Removal of N-Linked Glycosylation Enhances PD-L1 Detection and Predicts Anti-PD-1/PD-L1 Therapeutic Efficacy. Cancer Cell. 2019 08 12; 36(2):168-178.e4.
PMID:
31327656
; PMCID:
PMC6793936
.
Citations:
92
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Chan LC, Li CW,
Xia W
, Hsu JM, Lee HH, Cha JH, Wang HL, Yang WH, Yen EY, Chang WC, Zha Z,
Lim SO
, Lai YJ, Liu C, Liu J, Dong Q, Yang Y, Sun L, Wei Y,
Nie L
, Hsu JL, Li H, Ye Q, Hassan MM,
Amin HM
,
Kaseb AO
, Lin X, Wang SC,
Hung MC
. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. J Clin Invest. 2019 07 15; 129(8):3324-3338.
PMID:
31305264
; PMCID:
PMC6668668
.
Citations:
90
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Wang P, Gong Y, Guo T, Li M, Fang L, Yin S, Kamran M, Liu Y, Xu J, Xu L, Peng F, Xue X, Yang M,
Hung MC
, Lam EW, Gu C, Wang C, Zhan Q, Liu Q. Activation of Aurora A kinase increases YAP stability via blockage of autophagy. Cell Death Dis. 2019 06 03; 10(6):432.
PMID:
31160567
; PMCID:
PMC6547697
.
Citations:
17
Fields:
Cel
Cell Biology
Int
Internal Medicine
Translation:
Humans
Cells
Hu Q, Ye Y, Chan LC, Li Y, Liang K, Lin A, Egranov SD, Zhang Y,
Xia W
, Gong J, Pan Y, Chatterjee SS,
Yao J
, Evans KW, Nguyen TK, Park PK, Liu J,
Coarfa C
, Donepudi SR, Putluri V,
Putluri N
,
Sreekumar A
, Ambati CR, Hawke DH, Marks JR,
Gunaratne PH
,
Caudle AS
,
Sahin AA
, Hortobagyi GN,
Meric-Bernstam F
, Chen L,
Yu D
,
Hung MC
,
Curran MA
, Han L, Lin C, Yang L. Oncogenic lncRNA downregulates cancer cell antigen presentation and intrinsic tumor suppression. Nat Immunol. 2019 07; 20(7):835-851.
PMID:
31160797
; PMCID:
PMC6619502
.
Citations:
113
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Ju HQ, Lu YX, Chen DL, Zuo ZX, Liu ZX, Wu QN, Mo HY, Wang ZX, Wang DS, Pu HY, Zeng ZL, Li B, Xie D, Huang P,
Hung MC
,
Chiao PJ
, Xu RH. Modulation of Redox Homeostasis by Inhibition of MTHFD2 in Colorectal Cancer: Mechanisms and Therapeutic Implications. J Natl Cancer Inst. 2019 Jun 01; 111(6):584-596.
PMID:
30534944
; PMCID:
PMC6579745
.
Citations:
53
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen MK, Du Y, Sun L, Hsu JL, Wang YH, Gao Y, Huang J,
Hung MC
. H2O2 induces nuclear transport of the receptor tyrosine kinase c-MET in breast cancer cells via a membrane-bound retrograde trafficking mechanism. J Biol Chem. 2019 05 24; 294(21):8516-8528.
PMID:
30962283
; PMCID:
PMC6544865
.
Citations:
4
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Lee HH, Wang YN,
Hung MC
. Functional roles of the human ribonuclease A superfamily in RNA metabolism and membrane receptor biology. Mol Aspects Med. 2019 12; 70:106-116.
PMID:
30902663
; PMCID:
PMC6788960
.
Citations:
9
Fields:
Mol
Molecular Biology
Translation:
Humans
Cells
Zhu Y, Yang J, Xu D, Gao XM, Zhang Z, Hsu JL, Li CW, Lim SO, Sheng YY, Zhang Y, Li JH, Luo Q, Zheng Y, Zhao Y, Lu L, Jia HL,
Hung MC
, Dong QZ, Qin LX. Disruption of tumour-associated macrophage trafficking by the osteopontin-induced colony-stimulating factor-1 signalling sensitises hepatocellular carcinoma to anti-PD-L1 blockade. Gut. 2019 09; 68(9):1653-1666.
PMID:
30902885
.
Citations:
98
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Cells
Lu S, Han Z,
Hung MC
, Xu J, Xu Y, Zheng P, Zheng ZM, Zou L, Li Z, Zheng L, Kang Y, Yang Y, He L, Liao XC, Yu H, Yue Z, Liu SL, Zheng H. Racial profiling harms science. Science. 2019 Mar 22; 363(6433):1290-1292.
PMID:
30898924
.
Citations:
Fields:
Sci
Science
Liu YL,
Chou CK
, Kim M, Vasisht R, Kuo YA, Ang P, Liu C, Perillo EP, Chen YA, Blocher K, Horng H, Chen YI, Nguyen DT, Yankeelov TE,
Hung MC
, Dunn AK, Yeh HC. Assessing metastatic potential of breast cancer cells based on EGFR dynamics. Sci Rep. 2019 03 04; 9(1):3395.
PMID:
30833579
; PMCID:
PMC6399327
.
Citations:
19
Fields:
Sci
Science
Translation:
Humans
Cells
Wang D, Luo H, Huo Z, Chen M, Han Z,
Hung M
, Su B, Li Y, Wang X, Guo X, Xiao H, Lee D, Zhao R, Yang H. Irradiation-induced dynamic changes of gene signatures reveal gain of metastatic ability in nasopharyngeal carcinoma. Am J Cancer Res. 2019; 9(3):479-495.
PMID:
30949405
; PMCID:
PMC6448059
.
Citations:
5
Han Y, Chen MK, Wang HL, Hsu JL, Li CW, Chu YY, Liu CX,
Nie L
, Chan LC, Yam C, Wang SC, He GJ, Hortobagyi GN, Tan XD,
Hung MC
. Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. Am J Cancer Res. 2019; 9(3):608-618.
PMID:
30949414
; PMCID:
PMC6448061
.
Citations:
14
Wang EM, Akasaka H, Zhao J,
Varadhachary GR
, Lee JE,
Maitra A
,
Fleming JB
,
Hung MC
, Wang H,
Katz MHG
. Expression and Clinical Significance of Protein Kinase RNA-Like Endoplasmic Reticulum Kinase and Phosphorylated Eukaryotic Initiation Factor 2a in Pancreatic Ductal Adenocarcinoma. Pancreas. 2019 Mar; 48(3):323-328.
PMID:
30747823
; PMCID:
PMC6521859
.
Citations:
3
Fields:
Gas
Gastroenterology
Translation:
Humans
Cells
Li Y, Hu Q, Li C, Liang K, Xiang Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Ambati CR,
Putluri N
, Hawke DH, Han L,
Hung MC
,
Danesh FR
, Yang L, Lin C. PTEN-induced partial epithelial-mesenchymal transition drives diabetic kidney disease. J Clin Invest. 2019 03 01; 129(3):1129-1151.
PMID:
30741721
; PMCID:
PMC6391108
.
Citations:
21
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Park MK,
Yao Y
,
Xia W
, Setijono SR, Kim JH, Vila IK, Chiu HH, Wu Y, Lee MG, Kalb RG,
Hung MC
, Pandolfi PP, Song SJ, Song MS, Billalabeitia EG. PTEN self-regulates through USP11 via the PI3K-FOXO pathway to stabilize tumor suppression. Nat Commun. 2019 02 07; 10(1):636.
PMID:
30733438
; PMCID:
PMC6367354
.
Citations:
20
Fields:
Bio
Biology
Sci
Science
Translation:
Animals
Cells
Li H, Li CW, Li X, Ding Q, Guo L, Liu S, Liu C, Lai CC, Hsu JM, Dong Q,
Xia W
, Hsu JL,
Yamaguchi H
, Du Y, Lai YJ, Sun X, Koller PB, Ye Q,
Hung MC
. MET Inhibitors Promote Liver Tumor Evasion of the Immune Response by Stabilizing PDL1. Gastroenterology. 2019 05; 156(6):1849-1861.e13.
PMID:
30711629
; PMCID:
PMC6904924
.
Citations:
58
Fields:
Gas
Gastroenterology
Translation:
Animals
Cells
Hu Q, Li C, Wang S, Li Y, Wen B, Zhang Y, Liang K,
Yao J
, Ye Y, Hsiao H, Nguyen TK, Park PK, Egranov SD, Hawke DH, Marks JR, Han L,
Hung MC
, Zhang B, Lin C, Yang L. LncRNAs-directed PTEN enzymatic switch governs epithelial-mesenchymal transition. Cell Res. 2019 04; 29(4):286-304.
PMID:
30631154
; PMCID:
PMC6461864
.
Citations:
18
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Wang WJ, Hsu JM, Wang YN, Lee HH,
Yamaguchi H
, Liao HW,
Hung MC
. An essential role of PRMT1-mediated EGFR methylation in EGFR activation by ribonuclease 5. Am J Cancer Res. 2019; 9(1):180-185.
PMID:
30755821
; PMCID:
PMC6356926
.
Citations:
3
Dong Q, Du Y, Li H, Liu C, Wei Y, Chen MK, Zhao X, Chu YY, Qiu Y, Qin L,
Yamaguchi H
,
Hung MC
. EGFR and c-MET Cooperate to Enhance Resistance to PARP Inhibitors in Hepatocellular Carcinoma. Cancer Res. 2019 02 15; 79(4):819-829.
PMID:
30573522
; PMCID:
PMC6886123
.
Citations:
24
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Lee PC, Fang YF,
Yamaguchi H
, Wang WJ, Chen TC, Hong X, Ke B,
Xia W
, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF,
Nie L
, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Zhang R, Wang L,
Fang B
, Chen T, Wong KK, Hsu JL,
Hung MC
. Targeting PKCd as a Therapeutic Strategy against Heterogeneous Mechanisms of EGFR Inhibitor Resistance in EGFR-Mutant Lung Cancer. Cancer Cell. 2018 12 10; 34(6):954-969.e4.
PMID:
30537515
; PMCID:
PMC6886126
.
Citations:
26
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Yang Y, Hsu JM, Sun L, Chan LC, Li CW, Hsu JL, Wei Y,
Xia W
, Hou J, Qiu Y,
Hung MC
. Palmitoylation stabilizes PD-L1 to promote breast tumor growth. Cell Res. 2019 01; 29(1):83-86.
PMID:
30514902
; PMCID:
PMC6318320
.
Citations:
57
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Wang YN, Lee HH,
Hung MC
. A novel ligand-receptor relationship between families of ribonucleases and receptor tyrosine kinases. J Biomed Sci. 2018 Nov 19; 25(1):83.
PMID:
30449278
; PMCID:
PMC6241042
.
Citations:
6
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Hsu JM, Li CW, Lai YJ,
Hung MC
. Posttranslational Modifications of PD-L1 and Their Applications in Cancer Therapy. Cancer Res. 2018 11 15; 78(22):6349-6353.
PMID:
30442814
; PMCID:
PMC6242346
.
Citations:
77
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Tang Y, Joo D, Liu G, Tu H, You J, Jin J, Zhao X,
Hung MC
, Lin X. Linear ubiquitination of cFLIP induced by LUBAC contributes to TNFa-induced apoptosis. J Biol Chem. 2018 12 28; 293(52):20062-20072.
PMID:
30361438
; PMCID:
PMC6311529
.
Citations:
13
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Zhou L, Husted H, Moore T, Lu M, Deng D, Liu Y, Ramachandran V, Arumugam T, Niehrs C, Wang H,
Chiao P
,
Ling J
,
Curran MA
,
Maitra A
,
Hung MC
, Lee JE,
Logsdon CD
,
Hwang RF
. Suppression of stromal-derived Dickkopf-3 (DKK3) inhibits tumor progression and prolongs survival in pancreatic ductal adenocarcinoma. Sci Transl Med. 2018 10 24; 10(464).
PMID:
30355799
; PMCID:
PMC6752716
.
Citations:
8
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Kim J, Piao HL, Kim BJ, Yao F, Han Z, Wang Y, Xiao Z, Siverly AN, Lawhon SE, Ton BN, Lee H, Zhou Z,
Gan B
, Nakagawa S, Ellis MJ,
Liang H
,
Hung MC
, You MJ, Sun Y, Ma L. Long noncoding RNA MALAT1 suppresses breast cancer metastasis. Nat Genet. 2018 12; 50(12):1705-1715.
PMID:
30349115
; PMCID:
PMC6265076
.
Citations:
249
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Jewell BE, Liu M, Lu L, Zhou R, Tu J, Zhu D, Huo Z, Xu A, Wang D, Mata H, Jin W,
Xia W
, Rao PH, Zhao R,
Hung MC
,
Wang LL
, Lee DF. Generation of an induced pluripotent stem cell line from an individual with a heterozygous RECQL4 mutation. Stem Cell Res. 2018 12; 33:36-40.
PMID:
30312871
; PMCID:
PMC6317900
.
Citations:
1
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Yam C,
Hung MC
, Hortobagyi GN. CDK4/6 inhibitors in hormone receptor-positive, human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer: Are we at the finish line? Oncotarget. 2018 Sep 28; 9(76):34193-34195.
PMID:
30344934
; PMCID:
PMC6188130
.
Citations:
1
Fields:
Neo
Neoplasms
Wang T, Fan C, Yao A, Xu X, Zheng G, You Y,
Jiang C
, Zhao X, Hou Y,
Hung MC
, Lin X. The Adaptor Protein CARD9 Protects against Colon Cancer by Restricting Mycobiota-Mediated Expansion of Myeloid-Derived Suppressor Cells. Immunity. 2018 09 18; 49(3):504-514.e4.
PMID:
30231984
; PMCID:
PMC6880241
.
Citations:
47
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Cells
Zhang Y, Shi J, Liu X, Feng L, Gong Z, Koppula P, Sirohi K, Li X, Wei Y, Lee H, Zhuang L, Chen G, Xiao ZD,
Hung MC
, Chen J,
Huang P
, Li W,
Gan B
. BAP1 links metabolic regulation of ferroptosis to tumour suppression. Nat Cell Biol. 2018 10; 20(10):1181-1192.
PMID:
30202049
; PMCID:
PMC6170713
.
Citations:
208
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Shao B, Li CW,
Lim SO
, Sun L, Lai YJ, Hou J, Liu C, Chang CW, Qiu Y, Hsu JM, Chan LC, Zha Z, Li H,
Hung MC
. Deglycosylation of PD-L1 by 2-deoxyglucose reverses PARP inhibitor-induced immunosuppression in triple-negative breast cancer. Am J Cancer Res. 2018; 8(9):1837-1846.
PMID:
30323975
; PMCID:
PMC6176188
.
Citations:
27
Cha JH, Yang WH,
Xia W
, Wei Y, Chan LC,
Lim SO
, Li CW, Kim T, Chang SS, Lee HH, Hsu JL, Wang HL, Kuo CW, Chang WC, Hadad S, Purdie CA, McCoy AM, Cai S, Tu Y,
Litton JK
,
Mittendorf EA
,
Moulder SL
,
Symmans WF
, Thompson AM,
Piwnica-Worms H
, Chen CH, Khoo KH,
Hung MC
. Metformin Promotes Antitumor Immunity via Endoplasmic-Reticulum-Associated Degradation of PD-L1. Mol Cell. 2018 08 16; 71(4):606-620.e7.
PMID:
30118680
; PMCID:
PMC6786495
.
Citations:
177
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, Qiao Y,
Sharma A
, Zhang M,
Hung MC
,
Lin SH
. Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer. Clin Cancer Res. 2018 11 15; 24(22):5744-5756.
PMID:
30068711
.
Citations:
19
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Li CW, Lai YJ, Hsu JL,
Hung MC
. Activation of phagocytosis by immune checkpoint blockade. Front Med. 2018 Aug; 12(4):473-480.
PMID:
30062558
; PMCID:
PMC6941417
.
Citations:
9
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Xing Z, Zhang Y, Liang K, Yan L, Xiang Y, Li C, Hu Q, Jin F, Putluri V,
Putluri N
,
Coarfa C
,
Sreekumar A
, Park PK, Nguyen TK, Wang S, Zhou J, Zhou Y, Marks JR, Hawke DH,
Hung MC
, Yang L, Han L,
Ying H
, Lin C. Expression of Long Noncoding RNA YIYA Promotes Glycolysis in Breast Cancer. Cancer Res. 2018 08 15; 78(16):4524-4532.
PMID:
29967256
; PMCID:
PMC6126676
.
Citations:
32
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Sun LL, Yang RY, Li CW, Chen MK, Shao B, Hsu JM, Chan LC, Yang Y, Hsu JL, Lai YJ,
Hung MC
. Inhibition of ATR downregulates PD-L1 and sensitizes tumor cells to T cell-mediated killing. Am J Cancer Res. 2018; 8(7):1307-1316.
PMID:
30094103
; PMCID:
PMC6079156
.
Citations:
43
Yang Y, Li CW, Chan LC, Wei Y, Hsu JM,
Xia W
, Cha JH, Hou J, Hsu JL, Sun L,
Hung MC
. Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res. 2018 08; 28(8):862-864.
PMID:
29959401
; PMCID:
PMC6082826
.
Citations:
136
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Chou CK
, Huang PJ, Tsou PH, Wei Y, Lee HH, Wang YN, Liu YL, Shi C, Yeh HC, Kameoka J,
Hung MC
. A flow-proteometric platform for analyzing protein concentration (FAP): Proof of concept for quantification of PD-L1 protein in cells and tissues. Biosens Bioelectron. 2018 Oct 15; 117:97-103.
PMID:
29890396
.
Citations:
2
Fields:
Bio
Biotechnology
Translation:
Humans
Cells
Yang WH, Cha JH,
Xia W
, Lee HH, Chan LC, Wang YN, Hsu JL, Ren G,
Hung MC
. Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression. Cancer Res. 2018 07 15; 78(14):3761-3768.
PMID:
29789418
; PMCID:
PMC6050079
.
Citations:
6
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Hsu JM,
Xia W
, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW,
Lim SO
, Chang SS, Chen YC, Ren GX,
Hung MC
. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 2018 05 15; 9(1):1908.
PMID:
29765039
; PMCID:
PMC5954021
.
Citations:
131
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Xu A, Zhou R, Tu J, Huo Z, Zhu D, Wang D, Gingold JA, Mata H, Rao PH, Liu M, Mohamed AMT, Kong CSL, Jewell BE, Xia W, Zhao R,
Hung MC
, Lee DF. Establishment of a human embryonic stem cell line with homozygous TP53 R248W mutant by TALEN mediated gene editing. Stem Cell Res. 2018 05; 29:215-219.
PMID:
29730572
; PMCID:
PMC6021017
.
Citations:
2
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Peng JM, Bera R, Chiou CY, Yu MC, Chen TC, Chen CW, Wang TR, Chiang WL, Chai SP, Wei Y, Wang H,
Hung MC
, Hsieh SY. Actin cytoskeleton remodeling drives epithelial-mesenchymal transition for hepatoma invasion and metastasis in mice. Hepatology. 2018 06; 67(6):2226-2243.
PMID:
29171033
.
Citations:
59
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Cells
Zhang P
, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN,
Su X
, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G,
Sood AK
, Chen J, You MJ,
Sun SC
,
Liang H
, Huang Y, Yang X, Sun D, Sun Y,
Hung MC
, Ma L. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep. 2018 Apr 17; 23(3):823-837.
PMID:
29669287
; PMCID:
PMC5933875
.
Citations:
15
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Wang YN, Lee HH,
Chou CK
, Yang WH, Wei Y, Chen CT,
Yao J
, Hsu JL, Zhu C,
Ying H
,
Ye Y
, Wang WJ,
Lim SO
,
Xia W
, Ko HW, Liu X, Liu CG, Wu X, Wang H, Li D, Prakash LR,
Katz MH
, Kang Y, Kim M,
Fleming JB
,
Fogelman D
,
Javle M
,
Maitra A
,
Hung MC
. Angiogenin/Ribonuclease 5 Is an EGFR Ligand and a Serum Biomarker for Erlotinib Sensitivity in Pancreatic Cancer. Cancer Cell. 2018 04 09; 33(4):752-769.e8.
PMID:
29606349
; PMCID:
PMC5893359
.
Citations:
24
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen YH, Chung CC, Liu YC, Lai WC, Lin ZS, Chen TM, Li LY,
Hung MC
. YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts. Am J Cancer Res. 2018; 8(3):514-525.
PMID:
29637005
; PMCID:
PMC5883100
.
Citations:
7
Li CW,
Lim SO
, Chung EM, Kim YS, Park AH,
Yao J
, Cha JH,
Xia W
, Chan LC, Kim T, Chang SS, Lee HH,
Chou CK
, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM,
Yamaguchi H
,
Huang TH
,
Sahin AA
, Hortobagyi GN, Yoo SS,
Hung MC
. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 2018 02 12; 33(2):187-201.e10.
PMID:
29438695
; PMCID:
PMC5824730
.
Citations:
151
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J,
Xia W
, Rao PH,
Hung MC
, Zhao R, Lee DF. A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing. Stem Cell Res. 2018 03; 27:131-135.
PMID:
29414603
.
Citations:
4
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Wan L, Xu K, Wei Y, Zhang J, Han T, Fry C, Zhang Z, Wang YV, Huang L, Yuan M, Xia W, Chang WC, Huang WC, Liu CL, Chang YC, Liu J, Wu Y, Jin VX, Dai X, Guo J, Liu J, Jiang S, Li J, Asara JM, Brown M,
Hung MC
, Wei W. Phosphorylation of EZH2 by AMPK Suppresses PRC2 Methyltransferase Activity and Oncogenic Function. Mol Cell. 2018 01 18; 69(2):279-291.e5.
PMID:
29351847
; PMCID:
PMC5777296
.
Citations:
59
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Smith B, Hsu YH, Flores R, Gagea M, Craig S,
Hung MC
. Single oral dose acute and subacute toxicity of a c-MET tyrosine kinase inhibitor and CDK 4/6 inhibitor combination drug therapy. Am J Cancer Res. 2018; 8(1):183-191.
PMID:
29416931
; PMCID:
PMC5794732
.
Citations:
1
Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF,
Hung MC
, Suzuki HI, Chen PS. HIF-1a promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest. 2018 02 01; 128(2):625-643.
PMID:
29251629
; PMCID:
PMC5785260
.
Citations:
31
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Korphaisarn K,
Chou CK
, Xia WY, Clarke CN, Katkhuda R, Davis JS,
Raghav KP
, Liao HW, Wu JY,
Menter DG
,
Maru DM
,
Hung MC
, Kopetz S. Arginine methylation of EGFR: a new biomarker for predicting resistance to anti-EGFR treatment. Am J Cancer Res. 2017; 7(12):2587-2599.
PMID:
29312811
; PMCID:
PMC5752698
.
Citations:
2
Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH,
Hung MC
, Huang MT, Su JL. Erratum to: E1A-Mediated Inhibition of HSPA5 Suppresses Cell Migration and Invasion in Triple-Negative Breast Cancer. Ann Surg Oncol. 2017 12; 24(Suppl 3):685-686.
PMID:
28160139
.
Citations:
Fields:
Gen
General Surgery
Neo
Neoplasms
Wang S, Liang K, Hu Q, Li P, Song J, Yang Y,
Yao J
,
Mangala LS
, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y,
Xia W
,
Hung MC
, Marks JR,
Gallick GE
, Lopez-Berestein G, Flores ER,
Sood AK
, Huang S,
Yu D
, Yang L, Lin C. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest. 2017 12 01; 127(12):4498-4515.
PMID:
29130936
; PMCID:
PMC5707156
.
Citations:
89
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Nilsson MB, Sun H, Diao L, Tong P, Liu D, Li L, Fan Y, Poteete A,
Lim SO
, Howells K, Haddad V,
Gomez D
, Tran H, Pena GA, Sequist LV,
Yang JC
, Wang J, Kim ES, Herbst R, Lee JJ, Hong WK,
Wistuba I
,
Hung MC
,
Sood AK
,
Heymach JV
. Stress hormones promote EGFR inhibitor resistance in NSCLC: Implications for combinations with ?-blockers. Sci Transl Med. 2017 Nov 08; 9(415).
PMID:
29118262
; PMCID:
PMC5870120
.
Citations:
47
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Lin X, Chen W, Wei F, Zhou BP,
Hung MC
, Xie X. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly. Theranostics. 2017; 7(19):4805-4824.
PMID:
29187905
; PMCID:
PMC5706101
.
Citations:
29
Fields:
Dia
Diagnostic Imaging
Mol
Molecular Biology
Nan
Nanotechnology
The
Therapeutics
Translation:
Humans
Animals
Cells
Hossain MB
, Shifat R, Li J, Luo X,
Hess KR
, Rivera-Molina Y, Puerta Martinez F, Jiang H,
Lang FF
,
Hung MC
, Fueyo J,
Gomez-Manzano C
. TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation. Mol Cell Biol. 2017 Nov 01; 37(21).
PMID:
28760776
; PMCID:
PMC5640814
.
Citations:
8
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Yang R
,
Hung MC
. The role of T-cell immunoglobulin mucin-3 and its ligand galectin-9 in antitumor immunity and cancer immunotherapy. Sci China Life Sci. 2017 Oct; 60(10):1058-1064.
PMID:
29027155
.
Citations:
4
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Li CW,
Lim SO
, Hsu JL,
Hung MC
. Rational combination of immunotherapy for triple negative breast cancer treatment. Chin Clin Oncol. 2017 Oct; 6(5):54.
PMID:
29129094
.
Citations:
6
Fields:
Neo
Neoplasms
Translation:
Humans
Yamaguchi H, Du Y, Nakai K, Ding M, Chang SS, Hsu JL, Yao J, Wei Y, Nie L, Jiao S, Chang WC, Chen CH, Yu Y, Hortobagyi GN,
Hung MC
. EZH2 contributes to the response to PARP inhibitors through its PARP-mediated poly-ADP ribosylation in breast cancer. Oncogene. 2018 01 11; 37(2):208-217.
PMID:
28925391
; PMCID:
PMC5786281
.
Citations:
36
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Yi P
, Wang Z,
Feng Q
,
Chou CK
, Pintilie GD, Shen H,
Foulds CE
, Fan G,
Serysheva I
,
Ludtke SJ
, Schmid MF,
Hung MC
, Chiu W,
O'Malley BW
. Structural and Functional Impacts of ER Coactivator Sequential Recruitment. Mol Cell. 2017 Sep 07; 67(5):733-743.e4.
PMID:
28844863
; PMCID:
PMC5657569
.
Citations:
33
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Huang PJ,
Chou CK
, Chen CT,
Yamaguchi H
, Qu J, Muliana A,
Hung MC
, Kameoka J. Pneumatically Actuated Soft Micromold Device for Fabricating Collagen and Matrigel Microparticles. Soft Robot. 2017 Dec; 4(4):390-399.
PMID:
29251562
.
Citations:
1
Fields:
Bio
Biomedical Engineering
Tec
Technology
Nakai K,
Xia W
, Liao HW, Saito M,
Hung MC
,
Yamaguchi H
. The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells. Breast Cancer. 2018 Jan; 25(1):74-80.
PMID:
28643125
.
Citations:
16
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Liao HW,
Hung MC
. Intracaecal Orthotopic Colorectal Cancer Xenograft Mouse Model. Bio Protoc. 2017 Jun 05; 7(11).
PMID:
29104894
; PMCID:
PMC5667914
.
Citations:
6
Lin X, Chen W, Wei F, Zhou BP,
Hung MC
, Xie X. POMC maintains tumor-initiating properties of tumor tissue-derived long-term-cultured breast cancer stem cells. Int J Cancer. 2017 06 01; 140(11):2517-2525.
PMID:
28214331
.
Citations:
8
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Chen CT, Chen YC, Du Y, Han Z,
Ying H
,
Bouchard RR
, Hsu JL, Hsu JM, Mitcham TM, Chen MK, Sun HL, Chang SS, Li D, Chang P,
DePinho RA
,
Hung MC
. A tumor vessel-targeting fusion protein elicits a chemotherapeutic bystander effect in pancreatic ductal adenocarcinoma. Am J Cancer Res. 2017; 7(3):657-672.
PMID:
28401019
; PMCID:
PMC5385650
.
Citations:
3
Ju HQ, Ying H, Tian T, Ling J, Fu J, Lu Y, Wu M, Yang L, Achreja A, Chen G, Zhuang Z, Wang H, Nagrath D, Yao J,
Hung MC
,
DePinho RA
, Huang P, Xu RH,
Chiao PJ
. Mutant Kras- and p16-regulated NOX4 activation overcomes metabolic checkpoints in development of pancreatic ductal adenocarcinoma. Nat Commun. 2017 02 24; 8:14437.
PMID:
28232723
; PMCID:
PMC5333128
.
Citations:
36
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Hu J,
Bernatchez C
, Zhang L, Xia X,
Kleinerman ES
,
Hung MC
,
Hwu P
, Li S. Induction of NKG2D Ligands on Solid Tumors Requires Tumor-Specific CD8+ T Cells and Histone Acetyltransferases. Cancer Immunol Res. 2017 04; 5(4):300-311.
PMID:
28223282
; PMCID:
PMC5382872
.
Citations:
9
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Lin A, Hu Q, Li C, Xing Z, Ma G, Wang C, Li J, Ye Y,
Yao J
, Liang K, Wang S, Park PK, Marks JR, Zhou Y, Zhou J,
Hung MC
,
Liang H
, Hu Z, Shen H, Hawke DH, Han L, Zhou Y, Lin C, Yang L. The LINK-A lncRNA interacts with PtdIns(3,4,5)P3 to?hyperactivate AKT?and confer resistance to AKT?inhibitors. Nat Cell Biol. 2017 03; 19(3):238-251.
PMID:
28218907
; PMCID:
PMC5332298
.
Citations:
100
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Hsu DS, Hwang WL, Yuh CH, Chu CH, Ho YH, Chen PB, Lin HS, Lin HK, Wu SP, Lin CY, Hsu WH, Lan HY, Wang HJ, Tai SK,
Hung MC
, Yang MH. Lymphotoxin-? Interacts with Methylated EGFR to Mediate Acquired Resistance to Cetuximab in Head and Neck Cancer. Clin Cancer Res. 2017 Aug 01; 23(15):4388-4401.
PMID:
28196873
.
Citations:
16
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Jiao S,
Xia W
,
Yamaguchi H
, Wei Y, Chen MK, Hsu JM, Hsu JL, Yu WH, Du Y, Lee HH, Li CW,
Chou CK
,
Lim SO
, Chang SS,
Litton J
,
Arun B
, Hortobagyi GN,
Hung MC
. PARP Inhibitor Upregulates PD-L1 Expression and Enhances Cancer-Associated Immunosuppression. Clin Cancer Res. 2017 Jul 15; 23(14):3711-3720.
PMID:
28167507
; PMCID:
PMC5511572
.
Citations:
311
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Vila IK,
Yao Y
, Kim G,
Xia W
, Kim H, Kim SJ, Park MK, Hwang JP,
Hung MC
, Song SJ, Song MS, Gonz?lez-Billalabeitia E. A UBE2O-AMPKa2 Axis that Promotes Tumor Initiation and Progression Offers Opportunities for Therapy. Cancer Cell. 2017 02 13; 31(2):208-224.
PMID:
28162974
; PMCID:
PMC5463996
.
Citations:
49
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Zhao X, Guo Y,
Jiang C
, Chang Q, Zhang S, Luo T, Zhang B, Jia X,
Hung MC
, Dong C, Lin X. JNK1 negatively controls antifungal innate immunity by suppressing CD23 expression. Nat Med. 2017 Mar; 23(3):337-346.
PMID:
28112734
; PMCID:
PMC5592785
.
Citations:
31
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q,
Yao J
, Chen Z, Park PK, Hawke DH, Zhou J, Zhou Y, Zhang S,
Liang H
,
Hung MC
,
Gallick GE
, Han L, Lin C, Yang L. A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis. Nat Cell Biol. 2017 02; 19(2):106-119.
PMID:
28114269
; PMCID:
PMC5336186
.
Citations:
131
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Zuo X
, Xu W, Xu M, Tian R, Moussalli MJ, Mao F, Zheng X, Wang J, Morris JS, Gagea M,
Eng C
, Kopetz S,
Maru DM
,
Rashid A
,
Broaddus R
,
Wei D
,
Hung MC
,
Sood AK
,
Shureiqi I
. Metastasis regulation by PPARD expression in cancer cells. JCI Insight. 2017 01 12; 2(1):e91419.
PMID:
28097239
; PMCID:
PMC5214933
.
Citations:
34
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Liu CC, Lin SP, Hsu HS, Yang SH, Lin CH, Yang MH,
Hung MC
, Hung SC. Erratum: Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016 12 22; 7:14027.
PMID:
28004659
; PMCID:
PMC5196036
.
Citations:
1
Fields:
Bio
Biology
Sci
Science
Niu N, Zhang J, Zhang N, Mercado-Uribe I, Tao F, Han Z, Pathak S, Multani AS, Kuang J, Yao J, Bast RC, Sood AK,
Hung MC
, Liu J. Linking genomic reorganization to tumor initiation via the giant cell cycle. Oncogenesis. 2016 Dec 19; 5(12):e281.
PMID:
27991913
; PMCID:
PMC5177773
.
Citations:
52
Rezaeian AH, Li CF, Wu CY, Zhang X, Delacerda J, You MJ, Han F, Cai Z, Jeong YS, Jin G, Phan L, Chou PC, Lee MH,
Hung MC
, Sarbassov D, Lin HK. A hypoxia-responsive TRAF6-ATM-H2AX signalling axis promotes HIF1a activation, tumorigenesis and?metastasis. Nat Cell Biol. 2017 Jan; 19(1):38-51.
PMID:
27918549
; PMCID:
PMC5441459
.
Citations:
35
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Hsu JL,
Hung MC
. The role of HER2, EGFR, and other receptor tyrosine kinases in breast cancer. Cancer Metastasis Rev. 2016 12; 35(4):575-588.
PMID:
27913999
; PMCID:
PMC5215954
.
Citations:
77
Fields:
Neo
Neoplasms
Translation:
Humans
Long Y, Tsai WB, Wang D, Hawke DH, Savaraj N, Feun LG,
Hung MC
, Chen HH,
Kuo MT
. Argininosuccinate synthetase 1 (ASS1) is a common metabolic marker of chemosensitivity for targeted arginine- and glutamine-starvation therapy. Cancer Lett. 2017 03 01; 388:54-63.
PMID:
27913198
.
Citations:
9
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Lim SO
, Li CW,
Xia W
, Cha JH, Chan LC, Wu Y, Chang SS, Lin WC, Hsu JM, Hsu YH, Kim T, Chang WC, Hsu JL,
Yamaguchi H
, Ding Q, Wang Y, Yang Y, Chen CH,
Sahin AA
,
Yu D
, Hortobagyi GN,
Hung MC
. Deubiquitination and Stabilization of PD-L1 by CSN5. Cancer Cell. 2016 Dec 12; 30(6):925-939.
PMID:
27866850
; PMCID:
PMC5171205
.
Citations:
240
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Liu YL, Perillo EP, Liu C, Yu P,
Chou CK
,
Hung MC
, Dunn AK, Yeh HC. Segmentation of 3D Trajectories Acquired by TSUNAMI Microscope: An Application to EGFR Trafficking. Biophys J. 2016 Nov 15; 111(10):2214-2227.
PMID:
27851944
; PMCID:
PMC5112935
.
Citations:
12
Fields:
Bio
Biophysics
Translation:
Humans
Cells
Sun HL, Cui R, Zhou J, Teng KY, Hsiao YH, Nakanishi K, Fassan M, Luo Z, Shi G, Tili E, Kutay H, Lovat F, Vicentini C, Huang HL, Wang SW, Kim T, Zanesi N, Jeon YJ, Lee TJ, Guh JH,
Hung MC
, Ghoshal K, Teng CM, Peng Y, Croce CM. ERK Activation Globally Downregulates miRNAs through Phosphorylating Exportin-5. Cancer Cell. 2016 Nov 14; 30(5):723-736.
PMID:
27846390
; PMCID:
PMC5127275
.
Citations:
57
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Wang Y, Hsu JM,
Kang Y
, Wei Y, Lee PC, Chang SJ, Hsu YH, Hsu JL, Wang HL, Chang WC, Li CW, Liao HW, Chang SS,
Xia W
, Ko HW,
Chou CK
,
Fleming JB
, Wang H,
Hwang RF
, Chen Y, Qin J,
Hung MC
. Oncogenic Functions of Gli1 in Pancreatic Adenocarcinoma Are Supported by Its PRMT1-Mediated Methylation. Cancer Res. 2016 12 01; 76(23):7049-7058.
PMID:
27758883
; PMCID:
PMC5135656
.
Citations:
24
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Du Y,
Yamaguchi H
, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN,
Hung MC
. Corrigendum: Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 10 06; 22(10):1192.
PMID:
27711065
.
Citations:
1
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Lee CJ, Hsu LS, Yue CH, Lin H, Chiu YW, Lin YY, Huang CY,
Hung MC
, Liu JY. MZF-1/Elk-1 interaction domain as therapeutic target for protein kinase Ca-based triple-negative breast cancer cells. Oncotarget. 2016 Sep 13; 7(37):59845-59859.
PMID:
27542222
; PMCID:
PMC5312353
.
Citations:
8
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Hung MC
,
Yang R
, Sun Y. Powering Tumor Metastasis with Recycled Fuel. Cancer Cell. 2016 09 12; 30(3):374-375.
PMID:
27622330
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Chang SS, Yamaguchi H, Xia W, Lim SO, Khotskaya Y, Wu Y, Chang WC, Liu Q,
Hung MC
. Aurora A kinase activates YAP signaling in triple-negative breast cancer. Oncogene. 2017 03 02; 36(9):1265-1275.
PMID:
27593935
.
Citations:
25
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Ko HW, Lee HH, Huo L,
Xia W
, Yang CC, Hsu JL, Li LY, Lai CC, Chan LC, Cheng CC, Labaff AM, Liao HW,
Lim SO
, Li CW, Wei Y,
Nie L
,
Yamaguchi H
,
Hung MC
. GSK3? inactivation promotes the oncogenic functions of EZH2 and enhances methylation of H3K27 in human breast cancers. Oncotarget. 2016 Aug 30; 7(35):57131-57144.
PMID:
27494834
; PMCID:
PMC5302978
.
Citations:
20
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Li CW,
Lim SO
,
Xia W
, Lee HH, Chan LC, Kuo CW, Khoo KH, Chang SS, Cha JH, Kim T, Hsu JL, Wu Y, Hsu JM,
Yamaguchi H
, Ding Q, Wang Y,
Yao J
, Lee CC, Wu HJ,
Sahin AA
,
Allison JP
,
Yu D
, Hortobagyi GN,
Hung MC
. Glycosylation and stabilization of programmed death ligand-1 suppresses T-cell activity. Nat Commun. 2016 08 30; 7:12632.
PMID:
27572267
; PMCID:
PMC5013604
.
Citations:
292
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Chen CK, Yu WH, Cheng TY, Chen MW, Su CY, Yang YC, Kuo TC, Lin MT, Huang YC, Hsiao M, Hua KT,
Hung MC
, Kuo ML. Inhibition of VEGF165/VEGFR2-dependent signaling by LECT2 suppresses hepatocellular carcinoma angiogenesis. Sci Rep. 2016 08 10; 6:31398.
PMID:
27507763
; PMCID:
PMC4979047
.
Citations:
11
Fields:
Sci
Science
Translation:
Humans
Animals
Cells
Nakai K,
Hung MC
,
Yamaguchi H
. A perspective on anti-EGFR therapies targeting triple-negative breast cancer. Am J Cancer Res. 2016; 6(8):1609-23.
PMID:
27648353
; PMCID:
PMC5004067
.
Citations:
122
Chen YH, Chung CC, Liu YC, Yeh SP, Hsu JL,
Hung MC
, Su HL, Li LY. Enhancer of Zeste Homolog 2 and Histone Deacetylase 9c Regulate Age-Dependent Mesenchymal Stem Cell Differentiation into Osteoblasts and Adipocytes. Stem Cells. 2016 08; 34(8):2183-93.
PMID:
27250566
.
Citations:
23
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Humans
Animals
Cells
Liu CC, Lin SP, Hsu HS, Yang SH, Lin CH, Yang MH,
Hung MC
, Hung SC. Suspension survival mediated by PP2A-STAT3-Col XVII determines tumour initiation and metastasis in cancer stem cells. Nat Commun. 2016 06 16; 7:11798.
PMID:
27306323
; PMCID:
PMC4912642
.
Citations:
19
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Chang CC,
Zhang C
, Zhang Q, Sahin O, Wang H, Xu J, Xiao Y, Zhang J, Rehman SK, Li P,
Hung MC
, Behbod F,
Yu D
. Upregulation of lactate dehydrogenase a by 14-3-3? leads to increased glycolysis critical for breast cancer initiation and progression. Oncotarget. 2016 Jun 07; 7(23):35270-83.
PMID:
27150057
; PMCID:
PMC5085227
.
Citations:
15
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Rojas A, Zhang P, Wang Y,
Foo WC
, Xiao L, Wang J, Gores GJ,
Hung MC
,
Blechacz B
, Mu?oz NM. A Positive TGF-?/c-KIT Feedback Loop Drives Tumor Progression in Advanced Primary Liver Cancer. Neoplasia. 2016 06; 18(6):371-86.
PMID:
27292026
; PMCID:
PMC4909706
.
Citations:
16
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Chang TY, Chen HA, Chiu CF, Chang YW, Kuo TC, Tseng PC, Wang W,
Hung MC
, Su JL. Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL. Cancer Res. 2016 07 01; 76(13):3916-28.
PMID:
27216190
.
Citations:
9
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chou CK, Fan CC, Lin PS, Liao PY, Tung JC, Hsieh CH,
Hung MC
, Chen CH, Chang WC. Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. Oncotarget. 2016 May 03; 7(18):25742-54.
PMID:
27013588
; PMCID:
PMC5041940
.
Citations:
9
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Wu SY
, Rupaimoole R, Shen F,
Pradeep S
, Pecot CV,
Ivan C
, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, Filant J, Ehsanipour EA, Herbrich SM, Maiti SN, Huang L, Kim JH, Zhang X, Han HD, Armaiz-Pena GN, Seviour EG, Tucker S, Zhang M, Yang D, Cooper LJ, Ali-Fehmi R, Bar-Eli M, Lee JS,
Ram PT
,
Baggerly KA
, Lopez-Berestein G,
Hung MC
,
Sood AK
. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nat Commun. 2016 Apr 04; 7:11169.
PMID:
27041221
; PMCID:
PMC4822037
.
Citations:
61
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Animals
Cells
Yao J
, Huang Y, Lin C, Rimoldi D, Behren A, Cebon JS,
Hung MC
,
Weinstein JN
, Strausberg RL, Zhao Q, Caballero OL. Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity. Cancer Immunol Res. 2016 06; 4(6):552-61.
PMID:
27045022
.
Citations:
33
Fields:
All
Allergy and Immunology
Neo
Neoplasms
Translation:
Humans
Cells
Chou CK
, Tsou PH, Hsu JL, Lee HH, Wang YN, Kameoka J,
Hung MC
. Analysis of Individual Signaling Complexes by mMAPS, a Flow-Proteometric System. Curr Protoc Mol Biol. 2016 Apr 01; 114:20.11.1-20.11.22.
PMID:
27038387
; PMCID:
PMC4830480
.
Citations:
1
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Hossain MB, Shifat R, Johnson DG,
Bedford MT
, Gabrusiewicz KR, Cortes-Santiago N, Luo X,
Lu Z
, Ezhilarasan R,
Sulman EP
, Jiang H, Li SS,
Lang FF
, Tyler J,
Hung MC
, Fueyo J,
Gomez-Manzano C
. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv. 2016 04; 2(4):e1501290.
PMID:
27757426
; PMCID:
PMC5065225
.
Citations:
15
Fields:
Sci
Science
Translation:
Humans
Cells
Chen MK,
Hung MC
. Regulation of therapeutic resistance in cancers by receptor tyrosine kinases. Am J Cancer Res. 2016; 6(4):827-42.
PMID:
27186434
; PMCID:
PMC4859887
.
Citations:
9
Hsu MC, Hung WC,
Yamaguchi H
,
Lim SO
, Liao HW, Tsai CH,
Hung MC
. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. Am J Cancer Res. 2016; 6(3):628-38.
PMID:
27152240
; PMCID:
PMC4851842
.
Citations:
21
Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Liu B, Shi Q, Lam EW,
Hung MC
, Liu Q. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016 Jan 19; 7:10180.
PMID:
26782714
; PMCID:
PMC4735655
.
Citations:
63
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Du Y,
Yamaguchi H
, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN,
Hung MC
. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 Feb; 22(2):194-201.
PMID:
26779812
; PMCID:
PMC4754671
.
Citations:
106
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Li CW,
Xia W
,
Lim SO
, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J,
Yamaguchi H
, Lee DF, Wang H, Wang Y,
Chou CK
, Hsu JM, Lai YJ, LaBaff AM, Ding Q, Ko HW, Tsai FJ, Tsai CH, Hortobagyi GN,
Hung MC
. AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res. 2016 Mar 15; 76(6):1451-62.
PMID:
26759241
; PMCID:
PMC4794388
.
Citations:
47
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Lim SO
, Li CW,
Xia W
, Lee HH, Chang SS, Shen J, Hsu JL, Raftery D, Djukovic D, Gu H, Chang WC, Wang HL, Chen ML, Huo L, Chen CH, Wu Y,
Sahin A
,
Hanash SM
, Hortobagyi GN,
Hung MC
. EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape. Cancer Res. 2016 Mar 01; 76(5):1284-96.
PMID:
26759242
; PMCID:
PMC4775355
.
Citations:
87
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Wang C, Hu Z, Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Zhou Y, Marks JR, Liang H,
Hung MC
, Lin C, Yang L. The LINK-A lncRNA activates normoxic HIF1a signalling in triple-negative breast cancer. Nat Cell Biol. 2016 Feb; 18(2):213-24.
PMID:
26751287
; PMCID:
PMC4791069
.
Citations:
222
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Li N,
Dhar SS
, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK,
Hung MC
, Lee MG. JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis. Cancer Res. 2016 Feb 15; 76(4):831-43.
PMID:
26747897
; PMCID:
PMC4755879
.
Citations:
53
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Wu TJ, Chang SS, Li CW, Hsu YH, Chen TC, Lee WC, Yeh CT,
Hung MC
. Severe Hepatitis Promotes Hepatocellular Carcinoma Recurrence via NF-?B Pathway-Mediated Epithelial-Mesenchymal Transition after Resection. Clin Cancer Res. 2016 Apr 01; 22(7):1800-12.
PMID:
26655845
; PMCID:
PMC4818680
.
Citations:
12
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST,
Chou CK
, Tsou PH,
Yamaguchi H
, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S,
Hung MC
. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest. 2015 Dec; 125(12):4529-43.
PMID:
26571401
; PMCID:
PMC4665782
.
Citations:
64
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Lukianova-Hleb EY, Kim YS, Aryasomayajula B, Boulikas T, Phan J,
Hung MC
, Torchilin VP, O'Neill BE, Lapotko DO. Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model. Am J Cancer Res. 2015; 5(12):3534-47.
PMID:
26885444
; PMCID:
PMC4731629
.
Citations:
Chen CT, Chen YC,
Yamaguchi H
,
Hung MC
. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015; 5(12):3560-9.
PMID:
26885446
; PMCID:
PMC4731631
.
Citations:
8
Rahal OM,
Nie L
, Chan LC, Li CW, Hsu YH, Hsu J,
Yu D
,
Hung MC
. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. Am J Cancer Res. 2015; 5(12):3624-34.
PMID:
26885451
; PMCID:
PMC4731636
.
Citations:
1
Han B, Qu Y, Jin Y, Yu Y, Deng N, Wawrowsky K, Zhang X, Li N, Bose S, Wang Q, Sakkiah S, Abrol R, Jensen TW, Berman BP, Tanaka H, Johnson J, Gao B, Hao J, Liu Z, Buttyan R, Ray PS,
Hung MC
, Giuliano AE, Cui X. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep. 2015 Nov 03; 13(5):1046-58.
PMID:
26565916
; PMCID:
PMC4806384
.
Citations:
64
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Cells
Pradeep S
, Huang J, Mora EM, Nick AM, Cho MS,
Wu SY
, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W,
Mangala LS
,
Zand B
, Stagg LJ, Ladbury JE,
Ozpolat B
, Alpay SN, Nishimura M, Stone RL, Matsuo K, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P,
Hung MC
,
Coleman RL
, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB,
Sood AK
, Armaiz-Pe?a GN. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015 Nov 09; 28(5):610-622.
PMID:
26481148
; PMCID:
PMC4643364
.
Citations:
38
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Yang PW, Chiang TH, Hsieh CY, Huang YC, Wong LF,
Hung MC
, Tsai JC, Lee JM. The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2015 Dec; 30(9):2353-61.
PMID:
26450615
.
Citations:
5
Fields:
Bio
Biotechnology
Rad
Radiology
Translation:
Humans
Cells
Hu D, Gur M, Zhou Z, Gamper A,
Hung MC
, Fujita N, Lan L, Bahar I, Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015 Sep 30; 6:8419.
PMID:
26420673
; PMCID:
PMC4598737
.
Citations:
51
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Chen WS, Yen CJ, Chen YJ, Chen JY, Wang LY, Chiu SJ, Shih WL, Ho CY, Wei TT, Pan HL, Chien PH,
Hung MC
, Chen CC, Huang WC. miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. Oncotarget. 2015 Sep 22; 6(28):25962-74.
PMID:
26296971
; PMCID:
PMC4694878
.
Citations:
21
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Lee HH, Wang YN,
Hung MC
. Non-canonical signaling mode of the epidermal growth factor receptor family. Am J Cancer Res. 2015; 5(10):2944-58.
PMID:
26693051
; PMCID:
PMC4656722
.
Citations:
25
Dai HY, Chen HY, Lai WC,
Hung MC
, Li LY. Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma. Oncotarget. 2015 Sep 15; 6(27):23807-19.
PMID:
26247632
; PMCID:
PMC4695153
.
Citations:
2
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Perillo EP, Liu YL, Huynh K, Liu C,
Chou CK
,
Hung MC
, Yeh HC, Dunn AK. Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination. Nat Commun. 2015 Jul 29; 6:7874.
PMID:
26219252
; PMCID:
PMC4532916
.
Citations:
34
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB,
Mills GB
, Lopez-Berestein G,
Hung MC
, Sood AK, Bogdanov M, Ladbury JE. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. 2016 04 28; 35(17):2186-96.
PMID:
26212011
; PMCID:
PMC4792786
.
Citations:
10
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen MK,
Hung MC
. Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases. FEBS J. 2015 Oct; 282(19):3693-721.
PMID:
26096795
; PMCID:
PMC4591179
.
Citations:
34
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E,
Wu SY
,
Ivan C
, Moss TJ,
Ram PT
, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P,
Fuentes-Mattei E
, Kahraman N,
Pradeep S
,
Ozpolat B
, Tucker S,
Hung MC
,
Baggerly K
,
Bartholomeusz G
,
Calin G
,
Sood AK
, Lopez-Berestein G. The ZNF304-integrin axis protects against anoikis in cancer. Nat Commun. 2015 Jun 17; 6:7351.
PMID:
26081979
; PMCID:
PMC4830335
.
Citations:
29
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Yang CC, LaBaff A, Wei Y,
Nie L
,
Xia W
, Huo L,
Yamaguchi H
, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, Chan LC,
Yao J
, Kleer CG, Hortobagyi GN,
Hung MC
. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. Am J Transl Res. 2015; 7(6):1009-20.
PMID:
26279746
; PMCID:
PMC4532735
.
Citations:
23
Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V,
Hung MC
,
Chen J
. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Res. 2015 May 01; 75(9):1846-58.
PMID:
25877877
; PMCID:
PMC4417433
.
Citations:
11
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R,
Hung MC
, Schaniel C, Lemischka IR. Modeling familial cancer with induced pluripotent stem cells. Cell. 2015 Apr 09; 161(2):240-54.
PMID:
25860607
; PMCID:
PMC4397979
.
Citations:
88
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Zuo M, Rashid A, Churi C, Vauthey JN, Chang P, Li Y,
Hung MC
, Li D,
Javle M
. Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer. Br J Cancer. 2015 Mar 17; 112(6):1042-51.
PMID:
25742482
; PMCID:
PMC4366884
.
Citations:
20
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Song S
, Honjo S, Jin J, Chang SS, Scott AW, Chen Q,
Kalhor N
,
Correa AM
,
Hofstetter WL
,
Albarracin CT
, Wu TT, Johnson RL,
Hung MC
,
Ajani JA
. The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. Clin Cancer Res. 2015 Jun 01; 21(11):2580-90.
PMID:
25739674
; PMCID:
PMC4452384
.
Citations:
106
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL,
Hung MC
. Proteasome inhibition enhances the killing effect of BikDD gene therapy. Am J Transl Res. 2015; 7(2):319-27.
PMID:
25901200
; PMCID:
PMC4399095
.
Citations:
2
Xu J, Acharya S, Sahin O, Zhang Q, Saito Y,
Yao J
, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J,
Sahin AA
,
Zhang XH
,
Hung MC
, Zhang JD,
Yu D
. 14-3-3? turns TGF-?'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015 Feb 09; 27(2):177-92.
PMID:
25670079
; PMCID:
PMC4325275
.
Citations:
88
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Shen J,
Hung MC
. Signaling-mediated regulation of MicroRNA processing. Cancer Res. 2015 Mar 01; 75(5):783-91.
PMID:
25660948
; PMCID:
PMC4348149
.
Citations:
29
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK,
Lin SY
,
Hung MC
. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res. 2015 Feb; 25(2):225-36.
PMID:
25601159
; PMCID:
PMC4650576
.
Citations:
26
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Wang YN
, Huo L, Hsu JL,
Hung MC
. Biochemical fractionation of membrane receptors in the nucleus. Methods Mol Biol. 2015; 1234:99-112.
PMID:
25304351
.
Citations:
2
Fields:
Mol
Molecular Biology
Translation:
Cells
Huo L, Li CW,
Huang TH
, Lam YC,
Xia W
, Tu C, Chang WC, Hsu JL, Lee DF,
Nie L
,
Yamaguchi H
, Wang Y, Lang J, Li LY, Chen CH, Mishra L,
Hung MC
. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. Am J Transl Res. 2014; 6(6):649-63.
PMID:
25628777
; PMCID:
PMC4297334
.
Citations:
14
Chang YW, Chen HA, Tseng CF, Hong CC, Ma JT,
Hung MC
, Wu CH, Huang MT, Su JL. De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells. Oncotarget. 2014 Nov 15; 5(21):10558-70.
PMID:
25301734
; PMCID:
PMC4279393
.
Citations:
16
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH,
Hung MC
,
Lin C
,
Yang L
. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 2014 Nov 20; 159(5):1110-1125.
PMID:
25416949
; PMCID:
PMC4266991
.
Citations:
214
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q,
Huang TH
, Hsu JM, Brady SW,
Bartholomeusz C
, Ladbury JE, Stone S,
Yu D
,
Hung MC
, Esteva FJ. HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Mol Oncol. 2015 Mar; 9(3):586-600.
PMID:
25435280
; PMCID:
PMC4815926
.
Citations:
16
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH,
Hung MC
, Huang MT, Su JL. E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer. Ann Surg Oncol. 2015 Mar; 22(3):889-98.
PMID:
25212833
.
Citations:
12
Fields:
Gen
General Surgery
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Hong CC, Chen PS, Chiou J, Chiu CF, Yang CY, Hsiao M, Chang YW, Yu YH,
Hung MC
, Hsu NW, Shiah SG, Hsu NY, Su JL. miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression. Cancer Res. 2014 Nov 01; 74(21):6280-90.
PMID:
25205106
.
Citations:
16
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Zhang P
, Wei Y,
Wang L
,
Debeb BG
, Yuan Y, Zhang J, Yuan J, Wang M, Chen D,
Sun Y
,
Woodward WA
, Liu Y, Dean DC,
Liang H
, Hu Y, Ang KK,
Hung MC
,
Chen J
,
Ma L
. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep; 16(9):864-75.
PMID:
25086746
; PMCID:
PMC4150825
.
Citations:
187
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Thirumurthi U, Shen J,
Xia W
, LaBaff AM, Wei Y,
Li CW
, Chang WC, Chen CH, Lin HK,
Yu D
,
Hung MC
. MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Sci Signal. 2014 Jul 29; 7(336):ra71.
PMID:
25074979
; PMCID:
PMC4161976
.
Citations:
44
Fields:
Cel
Cell Biology
Phy
Physiology
Sci
Science
Translation:
Humans
Animals
Cells
Chou RH,
Wang YN
, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Wang HL, Kuo SC, Chen CH, Yu YL,
Hung MC
. EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell. 2014 Jul 28; 30(2):224-37.
PMID:
25073158
; PMCID:
PMC4149291
.
Citations:
50
Fields:
Cel
Cell Biology
Emb
Embryology
Translation:
Humans
Animals
Cells
Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY,
Hung MC
, Sher YP. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Res. 2014 Sep 15; 74(18):5229-43.
PMID:
25060522
.
Citations:
47
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Debeb BG
,
Gong Y
, Atkinson RL, Sneige N,
Huo L
, Gonzalez-Angulo AM,
Hung MC
, Valero V,
Ueno NT
,
Woodward WA
. EZH2 expression correlates with locoregional recurrence after radiation in inflammatory breast cancer. J Exp Clin Cancer Res. 2014 Jul 23; 33:58.
PMID:
25051981
; PMCID:
PMC4431485
.
Citations:
11
Fields:
Neo
Neoplasms
Translation:
Humans
Khotskaya YB, Goverdhan A, Shen J, Ponz-Sarvise M, Chang SS, Hsu MC, Wei Y,
Xia W
,
Yu D
,
Hung MC
. S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. Am J Transl Res. 2014; 6(4):361-76.
PMID:
25075253
; PMCID:
PMC4113498
.
Citations:
26
Yamaguchi H
,
Hung MC
. Regulation and Role of EZH2 in Cancer. Cancer Res Treat. 2014 Jul; 46(3):209-22.
PMID:
25038756
; PMCID:
PMC4132442
.
Citations:
129
Fields:
Neo
Neoplasms
Hsu YH,
Yao J
, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY,
Li CW
, Shen J, Chen MK,
Sahin AA
,
Sood A
,
Mills GB
,
Yu D
, Hortobagyi GN,
Hung MC
. Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res. 2014 Sep 01; 74(17):4822-35.
PMID:
24970481
; PMCID:
PMC4154991
.
Citations:
37
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chao CH, Chang CC, Wu MJ, Ko HW, Wang D,
Hung MC
, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest. 2014 Jul; 124(7):3093-106.
PMID:
24911147
; PMCID:
PMC4071406
.
Citations:
70
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Song S
,
Ajani JA
, Honjo S,
Maru DM
, Chen Q, Scott AW, Heallen TR, Xiao L,
Hofstetter WL
,
Weston B
,
Lee JH
, Wadhwa R, Sudo K,
Stroehlein JR
,
Martin JF
,
Hung MC
, Johnson RL. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 2014 Aug 01; 74(15):4170-82.
PMID:
24906622
; PMCID:
PMC4136429
.
Citations:
119
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Zhou G
, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM,
Sandulache VC
, Jasser SA,
Skinner HD
, Fitzgerald AL,
Osman AA
, Wei Y, Xia X, Songyang Z,
Mills GB
,
Hung MC
,
Caulin C
,
Liang J
,
Myers JN
. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell. 2014 Jun 19; 54(6):960-974.
PMID:
24857548
; PMCID:
PMC4067806
.
Citations:
119
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Xie X, Kong Y, Tang H, Yang L, Hsu JL,
Hung MC
. Targeted BikDD expression kills androgen-dependent and castration-resistant prostate cancer cells. Mol Cancer Ther. 2014 Jul; 13(7):1813-25.
PMID:
24785255
; PMCID:
PMC4120838
.
Citations:
8
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Animals
Yan M, Zhang Y, He B, Xiang J, Wang ZF, Zheng FM, Xu J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, Wang J, Wang Y, Li LH, Zeng YX, Lam EW,
Hung MC
, Liu Q. IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nat Commun. 2014 Apr 17; 5:3661.
PMID:
24739462
.
Citations:
38
Fields:
Bio
Biology
Sci
Science
Translation:
Humans
Cells
Chou CK
, Lee HH, Tsou PH, Chen CT, Hsu JM,
Yamaguchi H
,
Wang YN
, Lee HJ, Hsu JL, Lee JF, Kameoka J,
Hung MC
. mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes. Sci Signal. 2014 Mar 04; 7(315):rs1.
PMID:
24595109
; PMCID:
PMC4120848
.
Citations:
4
Fields:
Cel
Cell Biology
Phy
Physiology
Sci
Science
Translation:
Cells
Chen D,
Sun Y
, Yuan Y, Han Z,
Zhang P
, Zhang J, You MJ, Teruya-Feldstein J, Wang M, Gupta S,
Hung MC
,
Liang H
,
Ma L
. miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet. 2014 Feb; 10(2):e1004177.
PMID:
24586203
; PMCID:
PMC3937226
.
Citations:
63
Fields:
Gen
Genetics
Translation:
Humans
Animals
Cells
Zhang K,
Chou CK
, Xia X,
Hung MC
, Qin L. Block-Cell-Printing for live single-cell printing. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):2948-53.
PMID:
24516129
; PMCID:
PMC3939871
.
Citations:
40
Fields:
Sci
Science
Translation:
Cells
Chang YW,
Hung MC
, Su JL. The anti-tumor activity of E1A and its implications in cancer therapy. Arch Immunol Ther Exp (Warsz). 2014 Jun; 62(3):195-204.
PMID:
24504082
.
Citations:
8
Fields:
All
Allergy and Immunology
Translation:
Humans
Animals
Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH,
Sawaya R
,
Hung MC
,
Huang S
, Medema RH. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-?-dependent cancer metastasis. J Clin Invest. 2014 Feb; 124(2):564-79.
PMID:
24382352
; PMCID:
PMC3904622
.
Citations:
96
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Chiou GY, Chien CS, Wang ML, Chen MT, Yang YP, Yu YL, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI, Chen KH, Liu DM, Miller SA, Chen YW, Huang PI, Shih YH,
Hung MC
, Chiou SH. Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma. Mol Cell. 2013 Dec 12; 52(5):693-706.
PMID:
24332177
.
Citations:
47
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Zhang J,
Zhang P
, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D,
Sun Y
,
Hung MC
,
Chen J
,
Ma L
. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec; 15(12):1486-1494.
PMID:
24270891
; PMCID:
PMC3951854
.
Citations:
81
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Wagner KW, Alam H,
Dhar SS
, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH,
Ye Y
,
Multani AS
, Chan CH, Erez B, Saigal B, Chung J, Lin HK,
Wu X
,
Hung MC
,
Heymach JV
,
Lee MG
. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013 Dec; 123(12):5231-46.
PMID:
24200691
; PMCID:
PMC3859406
.
Citations:
81
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Shen J, Wang Y,
Hung MC
. RASAL2: wrestling in the combat of Ras activation. Cancer Cell. 2013 Sep 09; 24(3):277-9.
PMID:
24029223
.
Citations:
5
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Wang X, Saso H, Iwamoto T,
Xia W
, Gong Y, Pusztai L,
Woodward WA
, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN,
Hung MC
,
Ueno NT
. TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase. Cancer Res. 2013 Nov 01; 73(21):6516-25.
PMID:
24014597
; PMCID:
PMC6135947
.
Citations:
26
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Saldana SM, Lee HH, Lowery FJ, Khotskaya YB,
Xia W
,
Zhang C
, Chang SS,
Chou CK
, Steeg PS,
Yu D
,
Hung MC
. Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. PLoS One. 2013; 8(9):e73406.
PMID:
24039934
; PMCID:
PMC3764163
.
Citations:
18
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Khotskaya YB, Beck BH, Hurst DR, Han Z,
Xia W
,
Hung MC
, Welch DR. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Mol Carcinog. 2014 Dec; 53(12):1011-26.
PMID:
24000122
; PMCID:
PMC3939074
.
Citations:
9
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Marin-Muller C, Li D,
Bharadwaj U
, Li M,
Chen C
, Hodges SE,
Fisher WE
, Mo Q,
Hung MC
,
Yao Q
. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13.
PMID:
23989979
; PMCID:
PMC3920728
.
Citations:
43
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D,
Logothetis CJ
,
Hung MC
,
Zhang S
, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 01; 154(3):556-68.
PMID:
23911321
; PMCID:
PMC3845452
.
Citations:
199
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC,
Hung MC
, Weihua Z. EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. Prostate. 2013 Sep; 73(13):1453-61.
PMID:
23765757
.
Citations:
23
Fields:
Uro
Urology
Translation:
Humans
Cells
Huang TH
, Huo L,
Wang YN
,
Xia W
, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH,
Hung MC
. Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell. 2013 Jun 10; 23(6):796-810.
PMID:
23764002
; PMCID:
PMC3703149
.
Citations:
25
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen CT,
Hung MC
. Beyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapy. Am J Transl Res. 2013; 5(4):393-403.
PMID:
23724163
; PMCID:
PMC3665913
.
Citations:
18
Huang WC, Hsu SC, Huang SJ, Chen YJ, Hsiao YC, Zhang W, Fidler IJ,
Hung MC
. Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis. Am J Transl Res. 2013; 5(4):441-9.
PMID:
23724167
; PMCID:
PMC3665917
.
Citations:
5
Shen J,
Xia W
, Khotskaya YB, Huo L, Nakanishi K,
Lim SO
, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP,
Liu X
,
Liu CG
, Patel DJ,
Hung MC
. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature. 2013 May 16; 497(7449):383-7.
PMID:
23636329
; PMCID:
PMC3717558
.
Citations:
185
Fields:
Sci
Science
Translation:
Humans
Cells
Yu YL, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC,
Hung MC
. Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. PLoS One. 2013; 8(4):e61362.
PMID:
23593472
; PMCID:
PMC3620387
.
Citations:
30
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Yamaguchi H, Chang SS, Hsu JL,
Hung MC
. Signaling cross-talk in the resistance to HER family receptor targeted therapy. Oncogene. 2014 Feb 27; 33(9):1073-81.
PMID:
23542173
; PMCID:
PMC3874419
.
Citations:
69
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Yu YL, Chou RH, Shyu WC, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC,
Hung MC
. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Mol Med. 2013 Apr; 5(4):531-47.
PMID:
23526793
; PMCID:
PMC3628108
.
Citations:
60
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y,
Yao J
, Shi J, Kang T, Lorkiewicz P, St Clair D,
Hung MC
, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013 Mar 18; 23(3):316-31.
PMID:
23453623
; PMCID:
PMC3703516
.
Citations:
367
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP,
Wang YN
, Yamaguchi H, Miller SA,
Hung MC
. Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene. 2014 Feb 06; 33(6):756-70.
PMID:
23376851
; PMCID:
PMC3874427
.
Citations:
31
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Yi P
,
Xia W
, Wu RC,
Lonard DM
,
Hung MC
,
O'Malley BW
. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87.
PMID:
23388826
; PMCID:
PMC3576513
.
Citations:
23
Fields:
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY,
Hung MC
, Huang WC. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Mol Pharmacol. 2013 Apr; 83(4):857-69.
PMID:
23355539
.
Citations:
19
Fields:
Mol
Molecular Biology
Pha
Pharmacology
Translation:
Humans
Animals
Cells
Yamaguchi H
, Hsu JL, Chen CT,
Wang YN
, Hsu MC, Chang SS, Du Y, Ko HW, Herbst R,
Hung MC
. Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res. 2013 Feb 15; 19(4):845-54.
PMID:
23344263
; PMCID:
PMC3703145
.
Citations:
36
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Huang WC,
Hung MC
. Beyond NF-?B activation: nuclear functions of I?B kinase a. J Biomed Sci. 2013 Jan 23; 20:3.
PMID:
23343355
; PMCID:
PMC3563485
.
Citations:
38
Fields:
Med
Medicine (General)
Translation:
Humans
Cells
Liu CM, Hsieh CL, He YC, Lo SJ, Liang JA, Hsieh TF, Josson S, Chung LW,
Hung MC
, Sung SY. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. PLoS One. 2013; 8(1):e53795.
PMID:
23342005
; PMCID:
PMC3547060
.
Citations:
17
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Lin SP, Lee YT, Wang JY, Miller SA, Chiou SH,
Hung MC
, Hung SC. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS One. 2012; 7(11):e49605.
PMID:
23185379
; PMCID:
PMC3502468
.
Citations:
41
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KKC, Flores LG, Shao Y,
Hazle JD
, Yu D, Wei W, Sarbassov D,
Hung MC
, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell. 2012 11 09; 151(4):913-914.
PMID:
30360292
.
Citations:
15
Fields:
Cel
Cell Biology
Chen PS, Su JL,
Hung MC
. Dysregulation of microRNAs in cancer. J Biomed Sci. 2012 Oct 17; 19:90.
PMID:
23075324
; PMCID:
PMC3482395
.
Citations:
57
Fields:
Med
Medicine (General)
Translation:
Humans
Chen YH,
Hung MC
, Li LY. EZH2: a pivotal regulator in controlling cell differentiation. Am J Transl Res. 2012; 4(4):364-75.
PMID:
23145205
; PMCID:
PMC3493026
.
Citations:
26
Li L, Xie X, Luo J, Liu M, Xi S, Guo J, Kong Y, Wu M, Gao J, Xie Z, Tang J, Wang X, Wei W, Yang M,
Hung MC
, Xie X. Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. Mol Ther. 2012 Dec; 20(12):2326-34.
PMID:
23032974
; PMCID:
PMC3519992
.
Citations:
48
Fields:
Mol
Molecular Biology
The
Therapeutics
Translation:
Humans
Animals
Cells
Lin SP, Lee YT, Yang SH, Miller SA, Chiou SH,
Hung MC
, Hung SC. Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis. Cancer Lett. 2013 Jan 28; 328(2):226-34.
PMID:
23017941
.
Citations:
22
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen D,
Sun Y
, Wei Y,
Zhang P
, Rezaeian AH, Teruya-Feldstein J, Gupta S,
Liang H
, Lin HK,
Hung MC
,
Ma L
. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 2012 Oct; 18(10):1511-7.
PMID:
23001183
; PMCID:
PMC3684419
.
Citations:
208
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP,
Hung MC
, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 2012 Aug 03; 11(2):179-94.
PMID:
22862944
; PMCID:
PMC3413175
.
Citations:
84
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Hung MC
. On mammary gland growth factors: roles in normal development and in cancer. Cold Spring Harb Perspect Biol. 2012 Aug 01; 4(8):a013532.
PMID:
22855727
; PMCID:
PMC3405857
.
Citations:
2
Fields:
Bio
Biology
Translation:
Humans
Animals
Cells
Chen CT, Du Y,
Yamaguchi H
, Hsu JM, Kuo HP, Hortobagyi GN,
Hung MC
. Targeting the IKK?/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Mol Cancer Ther. 2012 Oct; 11(10):2212-21.
PMID:
22826466
; PMCID:
PMC3712288
.
Citations:
17
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Animals
Cells
Yu YL, Chou RH, Wu CH,
Wang YN
, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH,
Hung MC
. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J Biol Chem. 2012 Sep 07; 287(37):31015-26.
PMID:
22815474
; PMCID:
PMC3438934
.
Citations:
28
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Xie X, Li L, Xiao X, Guo J, Kong Y, Wu M, Liu W, Gao G, Hsu JL, Wei W,
Hung MC
, Xie X. Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models. Mol Cancer Ther. 2012 Sep; 11(9):1915-24.
PMID:
22752427
.
Citations:
13
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Animals
Cells
Hong S, Tsou PH,
Chou CK
,
Yamaguchi H
, Su CB,
Hung MC
, Kameoka J. Microfluidic three-dimensional hydrodynamic flow focusing for the rapid protein concentration analysis. Biomicrofluidics. 2012 Jun; 6(2):24132.
PMID:
23785388
; PMCID:
PMC3391308
.
Citations:
2
Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y,
Hazle JD
,
Yu D
, Wei W,
Sarbassov D
,
Hung MC
, Nakayama KI, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 2012 May 25; 149(5):1098-111.
PMID:
22632973
; PMCID:
PMC3586339
.
Citations:
184
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Yang PW,
Hung MC
, Hsieh CY, Tung EC, Wang YH, Tsai JC, Lee JM. The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2013 Feb; 28(2):605-14.
PMID:
22585382
.
Citations:
11
Fields:
Bio
Biotechnology
Rad
Radiology
Translation:
Humans
Cells
De Wever O, Hendrix A, Lambein K, Land D, Bracke M,
Hung MC
, Larsen AK, Emami S, Gespach C, Ouelaa-Benslama R, Sabbah M, Pr?vost G. Identification of a GaG??, AKT and PKCa signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition. Int J Oncol. 2012 Jul; 41(1):189-200.
PMID:
22552300
.
Citations:
10
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Wang YN
,
Hung MC
. Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family. Cell Biosci. 2012 Apr 20; 2(1):13.
PMID:
22520625
; PMCID:
PMC3418567
.
Citations:
68
Nie L
, Wu HJ, Hsu JM, Chang SS, Labaff AM,
Li CW
, Wang Y, Hsu JL,
Hung MC
. Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer. Am J Transl Res. 2012; 4(2):127-50.
PMID:
22611467
; PMCID:
PMC3353529
.
Citations:
113
Huang WC, Chen WS, Chen YJ, Wang LY, Hsu SC, Chen CC,
Hung MC
. Hepatitis B virus X protein induces IKKa nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells. J Cell Physiol. 2012 Apr; 227(4):1446-54.
PMID:
21618535
.
Citations:
18
Fields:
Cel
Cell Biology
Phy
Physiology
Translation:
Humans
Cells
Wang YN
, Lee HH, Lee HJ, Du Y,
Yamaguchi H
,
Hung MC
. Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J Biol Chem. 2012 May 11; 287(20):16869-79.
PMID:
22451678
; PMCID:
PMC3351284
.
Citations:
39
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Wang Y, Ding Q, Yen CJ,
Xia W
,
Izzo JG
, Lang JY,
Li CW
, Hsu JL,
Miller SA
, Wang X, Lee DF, Hsu JM, Huo L, Labaff AM, Liu D,
Huang TH
, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y,
Wang H
,
Ajani J
,
Hung MC
. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell. 2012 Mar 20; 21(3):374-87.
PMID:
22439934
; PMCID:
PMC3350095
.
Citations:
197
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ,
Hung MC
, Yang MH. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012 Mar 11; 14(4):366-74.
PMID:
22407364
.
Citations:
115
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Yamaguchi H
, Hsu JL,
Hung MC
. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Front Oncol. 2012; 2:15.
PMID:
22649777
; PMCID:
PMC3355968
.
Citations:
28
Li CW
,
Xia W
, Huo L,
Lim SO
, Wu Y, Hsu JL, Chao CH,
Yamaguchi H
, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, Yang MH, Hortobagyi GN,
Hung MC
. Epithelial-mesenchymal transition induced by TNF-a requires NF-?B-mediated transcriptional upregulation of Twist1. Cancer Res. 2012 Mar 01; 72(5):1290-300.
PMID:
22253230
; PMCID:
PMC3350107
.
Citations:
223
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Ling J
,
Kang Y
, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B,
Fleming JB
,
Wang H
,
Liu J
, Lemischka IR,
Hung MC
,
Chiao PJ
. KrasG12D-induced IKK2/?/NF-?B activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Jan 17; 21(1):105-20.
PMID:
22264792
; PMCID:
PMC3360958
.
Citations:
261
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Li X, Lu Y, Liang K, Hsu JM,
Albarracin C
,
Mills GB
,
Hung MC
, Fan Z. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene. 2012 Oct 04; 31(40):4372-83.
PMID:
22231447
; PMCID:
PMC3326223
.
Citations:
30
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Zhao H, Ho PC, Lo YH, Espejo A,
Bedford MT
,
Hung MC
, Wang SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PLoS One. 2012; 7(1):e29416.
PMID:
22238610
; PMCID:
PMC3251568
.
Citations:
22
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Cells
Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP,
Xia W
, Wei Y, Chiu PC,
Chou CK
, Du Y, Dhar D, Karin M, Chen CH,
Hung MC
. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84.
PMID:
22196886
; PMCID:
PMC3268914
.
Citations:
48
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Chang CJ,
Hung MC
. The role of EZH2 in tumour progression. Br J Cancer. 2012 Jan 17; 106(2):243-7.
PMID:
22187039
; PMCID:
PMC3261672
.
Citations:
157
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Hung MC
, Link W. Protein localization in disease and therapy. J Cell Sci. 2011 Oct 15; 124(Pt 20):3381-92.
PMID:
22010196
.
Citations:
131
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Ding Q, Chang CJ, Xie X,
Xia W
, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, Huo L, Cheng X, Chen YJ,
Li CW
, Jeng LB, Hsu JL, Li LY, Tan A,
Curley SA
,
Ellis LM
, Dubois RN,
Hung MC
. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest. 2011 Nov; 121(11):4526-36.
PMID:
21985787
; PMCID:
PMC3204827
.
Citations:
65
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Lang JY, Hsu JL,
Meric-Bernstam F
, Chang CJ, Wang Q, Bao Y,
Yamaguchi H
, Xie X,
Woodward WA
, Yu D, Hortobagyi GN,
Hung MC
. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell. 2011 Sep 13; 20(3):341-56.
PMID:
21907925
; PMCID:
PMC3172580
.
Citations:
37
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Su JL, Cheng X,
Yamaguchi H
, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT,
Wang YN
, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN,
Hung MC
. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011 Nov 01; 71(21):6878-87.
PMID:
21911455
; PMCID:
PMC3242367
.
Citations:
24
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH,
Hung MC
, Way TD, Kuo SC. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. Eur J Pharmacol. 2011 Nov 16; 670(1):96-104.
PMID:
21907193
.
Citations:
4
Fields:
Pha
Pharmacology
Translation:
Humans
Animals
Cells
Le XF, Mao W, He G,
Claret FX
, Xia W, Ahmed AA,
Hung MC
,
Siddik ZH
, Bast RC. The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. J Natl Cancer Inst. 2011 Sep 21; 103(18):1403-22.
PMID:
21813412
; PMCID:
PMC3176777
.
Citations:
13
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Yang JY,
Hung MC
. Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets. 2011 Aug; 12(9):1284-90.
PMID:
21443462
; PMCID:
PMC3149891
.
Citations:
37
Fields:
Dru
Drug Therapy
Translation:
Humans
Animals
Cells
Jan CI, Yu CC,
Hung MC
, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. J Pathol. 2011 Nov; 225(3):424-37.
PMID:
21710689
.
Citations:
24
Fields:
Pat
Pathology
Translation:
Humans
Chen YJ, Huang WC, Wei YL, Hsu SC, Yuan P, Lin HY,
Wistuba II
,
Lee JJ
, Yen CJ, Su WC, Chang KY, Chang WC, Chou TC,
Chou CK
, Tsai CH,
Hung MC
. Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells. PLoS One. 2011; 6(6):e21428.
PMID:
21731744
; PMCID:
PMC3121773
.
Citations:
37
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Humans
Animals
Cells
Banerjee A, Lang JY,
Hung MC
, Sengupta K, Banerjee SK, Baksi K, Banerjee DK. Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin. J Biol Chem. 2011 Aug 19; 286(33):29127-29138.
PMID:
21676868
; PMCID:
PMC3190720
.
Citations:
50
Fields:
Bio
Biochemistry
Translation:
Humans
Animals
Cells
Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH,
Hung MC
, Hung SC. Mesenchymal stem cells promote formation of colorectal tumors in mice. Gastroenterology. 2011 Sep; 141(3):1046-56.
PMID:
21699785
.
Citations:
76
Fields:
Gas
Gastroenterology
Translation:
Humans
Animals
Cells
Chen CT,
Yamaguchi H
, Lee HJ, Du Y, Lee HH,
Xia W
, Yu WH, Hsu JL, Yen CJ, Sun HL, Wang Y, Yeh ET, Hortobagyi GN,
Hung MC
. Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase. Mol Cancer Ther. 2011 Aug; 10(8):1327-36.
PMID:
21610170
; PMCID:
PMC3155219
.
Citations:
10
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Animals
Cells
Li LY, Chen H, Hsieh YH,
Wang YN
, Chu HJ, Chen YH, Chen HY, Chien PJ, Ma HT, Tsai HC, Lai CC, Sher YP, Lien HC, Tsai CH,
Hung MC
. Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res. 2011 Jun 15; 71(12):4269-79.
PMID:
21555369
; PMCID:
PMC3117049
.
Citations:
38
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Chou RH, Yu YL,
Hung MC
. The roles of EZH2 in cell lineage commitment. Am J Transl Res. 2011 May 15; 3(3):243-50.
PMID:
21654879
; PMCID:
PMC3102568
.
Citations:
46
Huang WC, Chen YJ, Li LY, Wei YL, Hsu SC, Tsai SL, Chiu PC, Huang WP,
Wang YN
, Chen CH, Chang WC, Chang WC, Chen AJ, Tsai CH,
Hung MC
. Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J Biol Chem. 2011 Jun 10; 286(23):20558-68.
PMID:
21487020
; PMCID:
PMC3121497
.
Citations:
88
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Jiang T, Grabiner B, Zhu Y,
Jiang C
, Li H, You Y, Lang J,
Hung MC
, Lin X. CARMA3 is crucial for EGFR-Induced activation of NF-?B and tumor progression. Cancer Res. 2011 Mar 15; 71(6):2183-92.
PMID:
21406399
; PMCID:
PMC3059846
.
Citations:
45
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Kim SJ
, Kim JS, Park ES,
Lee JS
, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D,
Mills GB
,
Hung MC
, Fidler IJ. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia. 2011 Mar; 13(3):286-98.
PMID:
21390191
; PMCID:
PMC3050871
.
Citations:
126
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chang CJ, Chao CH,
Xia W
, Yang JY, Xiong Y,
Li CW
, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT,
Yu D
,
Hung MC
. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol. 2011 Mar; 13(3):317-23.
PMID:
21336307
; PMCID:
PMC3075845
.
Citations:
368
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Sher YP, Liu SJ, Chang CM, Lien SP, Chen CH, Han Z, Li LY, Chen JS, Wu CW,
Hung MC
. Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer. Mol Cancer Ther. 2011 Apr; 10(4):637-47.
PMID:
21282355
.
Citations:
8
Fields:
Ant
Antineoplastic Agents
Translation:
Animals
Cells
Hsu JM, Chen CT,
Chou CK
, Kuo HP, Li LY, Lin CY, Lee HJ,
Wang YN
, Liu M, Liao HW, Shi B, Lai CC,
Bedford MT
, Tsai CH,
Hung MC
. Crosstalk between Arg?1175 methylation and Tyr?1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol. 2011 Feb; 13(2):174-81.
PMID:
21258366
; PMCID:
PMC3048027
.
Citations:
104
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Chen YH, Yeh FL, Yeh SP, Ma HT, Hung SC,
Hung MC
, Li LY. Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2. J Biol Chem. 2011 Mar 25; 286(12):10671-80.
PMID:
21247904
; PMCID:
PMC3060518
.
Citations:
29
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Yu YL, Chou RH, Chen LT, Shyu WC, Hsieh SC, Wu CS, Zeng HJ, Yeh SP, Yang DM, Hung SC,
Hung MC
. EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling. J Biol Chem. 2011 Mar 18; 286(11):9657-67.
PMID:
21216957
; PMCID:
PMC3059014
.
Citations:
29
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH,
Woodward WA
, Hsu JM, Hortobagyi GN,
Hung MC
. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-?-catenin signaling. Cancer Cell. 2011 Jan 18; 19(1):86-100.
PMID:
21215703
; PMCID:
PMC3041516
.
Citations:
207
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Zhao H, Lo YH, Ma L, Waltz SE, Gray JK,
Hung MC
, Wang SC. Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth. Mol Cancer Ther. 2011 Jan; 10(1):29-36.
PMID:
21220489
; PMCID:
PMC3066081
.
Citations:
45
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Animals
Cells
Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY,
Shi X
, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W,
Hung MC
, Patel DJ,
Barton MC
. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16; 468(7326):927-32.
PMID:
21164480
; PMCID:
PMC3058826
.
Citations:
205
Fields:
Sci
Science
Translation:
Humans
Cells
Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC,
Hung MC
. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol. 2011 Jan; 13(1):87-94.
PMID:
21131960
; PMCID:
PMC3076036
.
Citations:
195
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, Horton LW, Zaja-Milatovic S, Collins-Burow BM, Wadsworth S, Beckman BS, Wood CE,
Fuqua SA
, Nephew KP, Dent P, Worthylake RA, Curiel TJ,
Hung MC
, Richmond A, Burow ME. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res. 2011 Jan 15; 71(2):603-13.
PMID:
21123450
; PMCID:
PMC3140407
.
Citations:
89
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Song H,
Li CW
, Labaff AM,
Lim SO
, Li LY, Kan SF, Chen Y, Zhang K, Lang J, Xie X, Wang Y, Huo LF, Hsu SC, Chen X, Zhao Y,
Hung MC
. Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors. Biochem Biophys Res Commun. 2011 Jan 07; 404(1):68-73.
PMID:
21094134
; PMCID:
PMC3049249
.
Citations:
16
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Animals
Cells
Jin Q, Yuan LX, Boulbes D, Baek JM,
Wang YN
, Gomez-Cabello D, Hawke DH,
Yeung SC
, Lee MH, Hortobagyi GN,
Hung MC
, Esteva FJ. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res. 2010; 12(6):R96.
PMID:
21080941
; PMCID:
PMC3046439
.
Citations:
47
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Liang K, Esteva FJ,
Albarracin C
, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT,
Mills GB
, Hortobagyi GN,
Mendelsohn J
,
Hung MC
,
Fan Z
. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 2010 Nov 16; 18(5):423-35.
PMID:
21075308
; PMCID:
PMC3022383
.
Citations:
69
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Beyer I, Li Z, Persson J, Liu Y, van Rensburg R, Yumul R, Zhang XB,
Hung MC
, Lieber A. Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab. Mol Ther. 2011 Mar; 19(3):479-89.
PMID:
21081901
; PMCID:
PMC3048180
.
Citations:
32
Fields:
Mol
Molecular Biology
The
Therapeutics
Translation:
Humans
Animals
Cells
Cheng X, Xia W, Yang JY, Hsu JL,
Chou CK
, Sun HL, Wyszomierski SL,
Mills GB
, Muller WJ, Yu D,
Hung MC
. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochem Biophys Res Commun. 2010 Dec 03; 403(1):103-7.
PMID:
21040707
; PMCID:
PMC3001223
.
Citations:
14
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Animals
Wang YN
,
Yamaguchi H
, Huo L, Du Y, Lee HJ, Lee HH, Wang H, Hsu JM,
Hung MC
. The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem. 2010 Dec 03; 285(49):38720-9.
PMID:
20937808
; PMCID:
PMC2992305
.
Citations:
65
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Hong S, Wang YN,
Yamaguchi H
, Sreenivasappa H,
Chou CK
, Tsou PH,
Hung MC
, Kameoka J. MEASUREMENT of Protein 53 Diffusion Coefficient in Live HeLa Cells Using Raster Image Correlation Spectroscopy (RICS). J Biomater Nanobiotechnol. 2010 Oct; 1(1):31-36.
PMID:
21804949
; PMCID:
PMC3146256
.
Citations:
4
Chou CK
, Jing N,
Yamaguchi H
, Tsou PH, Lee HH, Chen CT,
Wang YN
, Hong S, Su C, Kameoka J,
Hung MC
. Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. Analyst. 2010 Nov; 135(11):2907-12.
PMID:
20877860
; PMCID:
PMC3001224
.
Citations:
1
Fields:
Che
Chemistry Techniques
Translation:
Humans
Cells
Luyimbazi D,
Akcakanat A
, McAuliffe PF, Zhang L, Singh G, Gonzalez-Angulo AM, Chen H,
Do KA
, Zheng Y,
Hung MC
,
Mills GB
,
Meric-Bernstam F
. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol Cancer Ther. 2010 Oct; 9(10):2770-84.
PMID:
20876744
; PMCID:
PMC2965451
.
Citations:
33
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Cells
Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natschke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K,
Hung MC
, Lee EY, Lee KH. Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent. J Nat Prod. 2010 Sep 24; 73(9):1553-8.
PMID:
20738103
; PMCID:
PMC2954497
.
Citations:
7
Fields:
Pha
Pharmacology
Translation:
Humans
Animals
Cells
Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T,
Ding Z
, Belousov R, Bill K, Luo X,
Lazar A
, Dicker A,
Mills GB
,
Hung MC
, Lev D. Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. 2011 Jan 27; 30(4):457-70.
PMID:
20856200
; PMCID:
PMC3010301
.
Citations:
104
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Cheng X,
Xia W
, Yang JY, Hsu JL, Lang JY,
Chou CK
, Du Y, Sun HL, Wyszomierski SL,
Mills GB
, Muller WJ,
Yu D
,
Hung MC
. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Res. 2010 Oct 01; 70(19):7684-9.
PMID:
20841468
; PMCID:
PMC2948588
.
Citations:
9
Fields:
Neo
Neoplasms
Translation:
Animals
Cells
Huo L,
Wang YN
,
Xia W
, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL,
Huang TH
, Ding Q, Chen CH, Tsai CH,
Hung MC
. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16125-30.
PMID:
20802156
; PMCID:
PMC2941329
.
Citations:
53
Fields:
Sci
Science
Translation:
Humans
Cells
Lu C, Han HD,
Mangala LS
, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN,
Hu W
, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA,
Schmandt R
, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC,
Coleman RL
,
Calin GA
, Denkbas EB, Lim JY,
Lee JS
,
Kundra V
, Birrer MJ,
Hung MC
, Lopez-Berestein G,
Sood AK
. Regulation of tumor angiogenesis by EZH2. Cancer Cell. 2010 Aug 09; 18(2):185-97.
PMID:
20708159
; PMCID:
PMC2923653
.
Citations:
201
Fields:
Neo
Neoplasms
Translation:
Animals
Cells
Yamaguchi H, Chen CT, Chou CK, Pal A, Bornmann W, Hortobagyi GN,
Hung MC
. Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation. Oncogene. 2010 Oct 14; 29(41):5619-29.
PMID:
20676141
; PMCID:
PMC2955174
.
Citations:
13
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Wang YN
, Wang H,
Yamaguchi H
, Lee HJ, Lee HH,
Hung MC
. COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):498-504.
PMID:
20674546
; PMCID:
PMC2935258
.
Citations:
64
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Cells
Su JL, Chen PB, Chen YH, Chen SC, Chang YW, Jan YH, Cheng X, Hsiao M,
Hung MC
. Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Res. 2010 Jun 15; 70(12):5096-108.
PMID:
20501832
; PMCID:
PMC2891368
.
Citations:
29
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chou CK
, Jing N,
Yamaguchi H
, Tsou PH, Lee HH, Chen CT,
Wang YN
, Hong S, Su C, Kameoka J,
Hung MC
. High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab Chip. 2010 Jul 21; 10(14):1793-8.
PMID:
20498894
; PMCID:
PMC2919816
.
Citations:
4
Fields:
Bio
Biotechnology
Che
Chemistry
Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L,
Hung MC
, Bonfiglio T, Hicks DG, Tang P. The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines. Breast Cancer (Auckl). 2010 May 20; 4:35-41.
PMID:
20697531
; PMCID:
PMC2914277
.
Citations:
312
Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y,
Andreeff M
, Hortobagyi GN,
Hung MC
. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Res. 2010 Jun 01; 70(11):4709-18.
PMID:
20484037
; PMCID:
PMC2895805
.
Citations:
37
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Wang YN, Yamaguchi H, Hsu JM,
Hung MC
. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene. 2010 Jul 15; 29(28):3997-4006.
PMID:
20473332
; PMCID:
PMC2904849
.
Citations:
98
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS,
Wang H
,
Sen S
,
Hung MC
,
Mills GB
, Chang S,
Multani AS
, Mercado-Uribe I,
Liu J
. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15; 16(12):3171-81.
PMID:
20423983
; PMCID:
PMC2930838
.
Citations:
63
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J,
Torres K
, Langley RR,
Lazar AJ
,
Hung MC
, Lev D. Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One. 2010 Apr 16; 5(4):e10105.
PMID:
20419128
; PMCID:
PMC2855704
.
Citations:
99
Fields:
Med
Medicine (General)
Sci
Science
Translation:
Animals
Cells
Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY,
Hung MC
, Pandolfi PP, Lin HK. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat Cell Biol. 2010 May; 12(5):457-67.
PMID:
20383141
; PMCID:
PMC3855841
.
Citations:
123
Fields:
Cel
Cell Biology
Translation:
Humans
Animals
Cells
Bredfeldt TG, Greathouse KL, Safe SH,
Hung MC
,
Bedford MT
,
Walker CL
. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol. 2010 May; 24(5):993-1006.
PMID:
20351197
; PMCID:
PMC2870935
.
Citations:
86
Fields:
End
Endocrinology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL,
Hung MC
, Lee EY, Lee KH. Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. J Med Chem. 2010 Mar 11; 53(5):2299-308.
PMID:
20148565
; PMCID:
PMC2849726
.
Citations:
16
Fields:
Che
Chemistry
Translation:
Humans
Animals
Cells
Zhang W
,
Konopleva M
,
Burks JK
, Dywer KC, Schober WD, Yang JY, McQueen TJ,
Hung MC
,
Andreeff M
. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res. 2010 Mar 15; 70(6):2424-34.
PMID:
20215498
; PMCID:
PMC2840060
.
Citations:
40
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Kuo HP, Lee DF, Chen CT, Liu M,
Chou CK
, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, Xing G, Zhao Y, Lin CH, Tsai SF, Fidler IJ,
Hung MC
. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal. 2010 Feb 09; 3(108):ra9.
PMID:
20145209
; PMCID:
PMC2874891
.
Citations:
41
Fields:
Cel
Cell Biology
Phy
Physiology
Sci
Science
Translation:
Humans
Animals
Cells
Liao Y,
Hung MC
. Physiological regulation of Akt activity and stability. Am J Transl Res. 2010 Jan 01; 2(1):19-42.
PMID:
20182580
; PMCID:
PMC2826820
.
Citations:
178
Kuo HP,
Hung MC
. Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? Am J Transl Res. 2010 Jan 01; 2(1):56-64.
PMID:
20182582
; PMCID:
PMC2826822
.
Citations:
13
Esteva FJ, Yu D,
Hung MC
, Hortobagyi GN. Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat Rev Clin Oncol. 2010 Feb; 7(2):98-107.
PMID:
20027191
.
Citations:
69
Fields:
Neo
Neoplasms
Translation:
Humans
Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY,
Hung MC
, Lee KH. Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. Bioorg Med Chem. 2010 Jan 15; 18(2):803-8.
PMID:
20034799
; PMCID:
PMC2821697
.
Citations:
5
Fields:
Bio
Biochemistry
Che
Chemistry
Translation:
Humans
Cells
Andre F, Xia W, Conforti R, Wei Y, Boulet T, Tomasic G, Spielmann M, Zoubir M, Berrada N, Arriagada R, Hortobagyi GN,
Hung MC
, Pusztai L, Delaloge S, Michiels S, Cristofanilli M. CXCR4 expression in early breast cancer and risk of distant recurrence. Oncologist. 2009 Dec; 14(12):1182-8.
PMID:
19939894
.
Citations:
31
Fields:
Neo
Neoplasms
Translation:
Humans
Chou CK
, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP,
Yamaguchi H
,
Wang YN
, Liu M, Wu HY, Liao PC, Yen CJ,
Hung MC
. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Mol Carcinog. 2009 Nov; 48(11):1048-58.
PMID:
19526459
; PMCID:
PMC2783450
.
Citations:
13
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Wang SC,
Hung MC
. Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors. Clin Cancer Res. 2009 Nov 01; 15(21):6484-9.
PMID:
19861462
; PMCID:
PMC5537741
.
Citations:
95
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Zhang D, LaFortune TA,
Krishnamurthy S
, Esteva FJ, Cristofanilli M, Liu P,
Lucci A
,
Singh B
,
Hung MC
, Hortobagyi GN,
Ueno NT
. Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer. Clin Cancer Res. 2009 Nov 01; 15(21):6639-48.
PMID:
19825949
; PMCID:
PMC2783487
.
Citations:
68
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Lee DF, Kuo HP, Liu M,
Chou CK
, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC,
Li CW
, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY,
Hung MC
. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 09; 36(1):131-40.
PMID:
19818716
; PMCID:
PMC2770835
.
Citations:
160
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Translation:
Humans
Animals
Cells
Kuo HP, Lee DF, Xia W, Wei Y,
Hung MC
. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochem Biophys Res Commun. 2009 Nov 27; 389(4):640-4.
PMID:
19766100
; PMCID:
PMC2762003
.
Citations:
13
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Animals
Cells
Lu J, Guo H, Treekitkarnmongkol W, Li P, Zhang J, Shi B, Ling C, Zhou X, Chen T,
Chiao PJ
, Feng X, Seewaldt VL, Muller WJ,
Sahin A
,
Hung MC
, Yu D. 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell. 2009 Sep 08; 16(3):195-207.
PMID:
19732720
; PMCID:
PMC2754239
.
Citations:
106
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Jiralerspong S, Gonzalez-Angulo AM,
Hung MC
. Expanding the arsenal: metformin for the treatment of triple-negative breast cancer? Cell Cycle. 2009 Sep 01; 8(17):2681.
PMID:
19717981
.
Citations:
10
Fields:
Cel
Cell Biology
Translation:
Humans
Cells
Lee WH,
Hung MC
, Iczkowski KA, Languino LR, Dubinett SM, Wang D. The launch of the american journal of translational research. Am J Transl Res. 2009 Sep 01; 1(1):i.
PMID:
19966932
; PMCID:
PMC2776285
.
Citations:
1
Kuo HP, Lee DF, Xia W, Lai CC, Li LY,
Hung MC
. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. Biochem Biophys Res Commun. 2009 Nov 06; 389(1):156-61.
PMID:
19716809
; PMCID:
PMC2753275
.
Citations:
10
Fields:
Bio
Biochemistry
Bio
Biophysics
Translation:
Humans
Animals
Cells
Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, Petersson F, Price JE, Schroit A,
Prieto VG
,
Hung MC
, Bar-Eli M. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem. 2009 Oct 16; 284(42):28845-55.
PMID:
19703903
; PMCID:
PMC2781430
.
Citations:
45
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Xie X, Hsu JL, Choi MG,
Xia W
,
Yamaguchi H
, Chen CT, Trinh BQ,
Lu Z
,
Ueno NT
, Wolf JK, Bast RC,
Hung MC
. A novel hTERT promoter-driven E1A therapeutic for ovarian cancer. Mol Cancer Ther. 2009 Aug; 8(8):2375-82.
PMID:
19671744
; PMCID:
PMC2759534
.
Citations:
18
Fields:
Ant
Antineoplastic Agents
Translation:
Humans
Animals
Cells
Sun HL, Tsai AC, Pan SL, Ding Q,
Yamaguchi H
, Lin CN,
Hung MC
, Teng CM. EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation. Clin Cancer Res. 2009 Aug 01; 15(15):4904-14.
PMID:
19622586
.
Citations:
11
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Xia W, Wei Y, Du Y,
Liu J
, Chang B, Yu YL, Huo LF, Miller S,
Hung MC
. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog. 2009 Jul; 48(7):610-7.
PMID:
19058255
; PMCID:
PMC2718429
.
Citations:
85
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Liu S
, Umezu-Goto M, Murph M,
Lu Y
, Liu W, Zhang F, Yu S, Stephens LC, Cui X, Murrow G, Coombes K, Muller W,
Hung MC
, Perou CM, Lee AV, Fang X,
Mills GB
. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell. 2009 Jun 02; 15(6):539-50.
PMID:
19477432
; PMCID:
PMC4157573
.
Citations:
207
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Jiralerspong S, Palla SL,
Giordano SH
,
Meric-Bernstam F
, Liedtke C, Barnett CM, Hsu L,
Hung MC
, Hortobagyi GN, Gonzalez-Angulo AM. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol. 2009 Jul 10; 27(20):3297-302.
PMID:
19487376
; PMCID:
PMC2736070
.
Citations:
351
Fields:
Neo
Neoplasms
Translation:
Humans
Liao Y,
Wei Y
, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK,
Sarbassov D
, Shi D,
Yu D
,
Hung MC
. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 2009 Jul 02; 28(26):2436-45.
PMID:
19448664
; PMCID:
PMC2748248
.
Citations:
43
Fields:
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Animals
Cells
Chen G,
Izzo J
, Demizu Y, Wang F, Guha S,
Wu X
,
Hung MC
,
Ajani JA
,
Huang P
. Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol. Antioxid Redox Signal. 2009 May; 11(5):1083-95.
PMID:
19187006
; PMCID:
PMC2842128
.
Citations:
14
Fields:
Met
Metabolism
Translation:
Humans
Cells
Cheng X,
Hung MC
. Regulation of breast cancer metastasis by atypical chemokine receptors. Clin Cancer Res. 2009 May 01; 15(9):2951-3.
PMID:
19383808
.
Citations:
1
Fields:
Neo
Neoplasms
Translation:
Humans
Animals
Hawthorne VS, Huang WC, Neal CL, Tseng LM,
Hung MC
, Yu D. ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Mol Cancer Res. 2009 Apr; 7(4):592-600.
PMID:
19372587
; PMCID:
PMC2689096
.
Citations:
29
Fields:
Cel
Cell Biology
Mol
Molecular Biology
Neo
Neoplasms
Translation:
Humans
Cells
Neal CL,
Yao J
, Yang W, Zhou X, Nguyen NT, Lu J, Danes CG, Guo H, Lan KH, Ensor J, Hittelman W,
Hung MC
, Yu D. 14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Res. 2009 Apr 15; 69(8):3425-32.
PMID:
19318578
; PMCID:
PMC2671640
.
Citations:
94
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Hsu SC, Miller SA, Wang Y,
Hung MC
. Nuclear EGFR is required for cisplatin resistance and DNA repair. Am J Transl Res. 2009 Mar 08; 1(3):249-58.
PMID:
19956435
; PMCID:
PMC2776325
.
Citations:
53
Yamaguchi H
, Woods NT, Piluso LG, Lee HH, Chen J,
Bhalla KN
, Monteiro A, Liu X,
Hung MC
, Wang HG. p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem. 2009 Apr 24; 284(17):11171-83.
PMID:
19265193
; PMCID:
PMC2670122
.
Citations:
66
Fields:
Bio
Biochemistry
Translation:
Humans
Cells
Huang WC,
Hung MC
. Induction of Akt activity by chemotherapy confers acquired resistance. J Formos Med Assoc. 2009 Mar; 108(3):180-94.
PMID:
19293033
.
Citations:
56
Fields:
Med
Medicine (General)
Translation:
Humans
Animals
Cells
Hung MC
,
Mills GB
, Yu D. Oxygen sensor boosts growth factor signaling. Nat Med. 2009 Mar; 15(3):246-7.
PMID:
19265822
.
Citations:
3
Fields:
Med
Medicine (General)
Mol
Molecular Biology
Translation:
Humans
Cells
Song S
, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K,
Hung MC
,
Bresalier RS
. Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity. Cancer Res. 2009 Feb 15; 69(4):1343-9.
PMID:
19190323
; PMCID:
PMC2990400
.
Citations:
73
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Yang JY,
Hung MC
. A new fork for clinical application: targeting forkhead transcription factors in cancer. Clin Cancer Res. 2009 Feb 01; 15(3):752-7.
PMID:
19188143
; PMCID:
PMC2676228
.
Citations:
113
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Hildebrandt MA
, Yang H,
Hung MC
,
Izzo JG
, Huang M, Lin J,
Ajani JA
,
Wu X
. Genetic variations in the PI3K/PTEN/AKT/mTOR pathway are associated with clinical outcomes in esophageal cancer patients treated with chemoradiotherapy. J Clin Oncol. 2009 Feb 20; 27(6):857-71.
PMID:
19164214
; PMCID:
PMC2738430
.
Citations:
80
Fields:
Neo
Neoplasms
Translation:
Humans
Cells
Lee DF, Kuo HP, Chen CT, Wei Y,
Chou CK
, Hung JY, Yen CJ,
Hung MC
. IKKbeta suppression of TSC1 function links the mTOR pathway with insulin resistance. Int J Mol Med. 2008 Nov; 22(5):633-8.
PMID:
18949383
; PMCID:
PMC2586899
.
Citations:
27
Fields:
Gen
Genetics
Mol
Molecular Biology
Translation:
Animals
Cells
Lee C, Dhillon J, Wang MY, Gao Y, Hu K, Park E, Astanehe A,
Hung MC
, Eirew P, Eaves CJ, Dunn SE. Targeting YB-1 in HER-2 overexpressing breast cancer cells induces apoptosis via the mTOR/STAT3 pathway and suppresses tumor growth in mice. Cancer Res. 2008 Nov 01; 68(21):8661-6.
PMID:
18974106
.