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MIEN-CHIE HUNG

TitleProfessor
InstitutionMD Anderson
DepartmentMolecular & Cellular Oncology
Address1515 Holcombe Blvd
Houston TX 77030-4009
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang WJ, Tang HT, Ou SC, Shen WJ, Chen CY, Li YC, Chang SY, Chang WC, Hsueh PR, Huang ST, Hung MC. Novel SARS-CoV-2 inhibition properties of the anti-cancer Kang Guan Recipe herbal formula. Cancer Lett. 2024 Aug 26; 217198. PMID: 39197583.
      Citations:    Fields:    
    2. Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B, Lei G, Mao C, Horbath AD, Yan Y, Cai S, Yao J, Jiang Y, Sun M, Liu X, Cheng J, Xu Z, Lee H, Li Q, Lu Z, Zhuang L, Chen MK, Alapati A, Yap TA, Hung MC, You MJ, Piwnica-Worms H, Gan B. BRCA1-Mediated Dual Regulation of Ferroptosis Exposes a Vulnerability to GPX4 and PARP Co-Inhibition in BRCA1-Deficient Cancers. Cancer Discov. 2024 Aug 02; 14(8):1476-1495. PMID: 38552003; PMCID: PMC11296921.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    3. Chen Z, Yu M, Zhang B, Jin L, Yu Q, Liu S, Zhou B, Yan J, Zhang W, Li X, Xu Y, Xiao Y, Zhou J, Fan J, Hung MC, Ye Q, Li H, Guo L. SIGLEC15, negatively correlated with PD-L1 in HCC, could induce CD8+ T cell apoptosis to promote immune evasion. Oncoimmunology. 2024; 13(1):2376264. PMID: 38988824; PMCID: PMC11236293.
      Citations:    Fields:    Translation:HumansAnimalsCells
    4. Liu CH, Shen PC, Lin WJ, Liu HC, Tsai MH, Huang TY, Chen IC, Lai YL, Wang YD, Hung MC, Cheng WC. LipidSig 2.0: integrating lipid characteristic insights into advanced lipidomics data analysis. Nucleic Acids Res. 2024 Jul 05; 52(W1):W390-W397. PMID: 38709887; PMCID: PMC11223864.
      Citations:    Fields:    
    5. Feng LL, Bie SY, Deng ZH, Bai SM, Shi J, Qin CL, Liu HL, Li JX, Chen WY, Zhou JY, Jiao CM, Ma Y, Qiu MB, Ai HS, Zheng J, Hung MC, Wang YL, Wan XB, Fan XJ. Ubiquitin-induced RNF168 condensation promotes DNA double-strand break repair. Proc Natl Acad Sci U S A. 2024 Jul 09; 121(28):e2322972121. PMID: 38968116; PMCID: PMC11252754.
      Citations:    Fields:    Translation:HumansCells
    6. Yamaguchi H, Hsu JM, Sun L, Wang SC, Hung MC. Advances and prospects of biomarkers for immune checkpoint inhibitors. Cell Rep Med. 2024 Jul 16; 5(7):101621. PMID: 38906149; PMCID: PMC11293349.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Le UNP, Chang YJ, Lu CH, Chen Y, Su WC, Chao ST, Baltina LA, Petrova SF, Li SR, Hung MC, Lai MMC, Baltina LA, Lin CW. Glycyrrhizic acid conjugates with amino acid methyl esters target the main protease, exhibiting antiviral activity against wild-type and nirmatrelvir-resistant SARS-CoV-2 variants. Antiviral Res. 2024 Jul; 227:105920. PMID: 38821317.
      Citations:    Fields:    Translation:HumansAnimalsCells
    8. Chen CY, Wang WJ, Wu CS, Wang SC, Chang WC, Hung MC. Tannic acids and proanthocyanidins in tea inhibit SARS-CoV-2 variants infection. Am J Cancer Res. 2024; 14(5):2555-2569. PMID: 38859869; PMCID: PMC11162682.
      Citations: 1     
    9. Lin CH, Chin Y, Zhou M, Sobol RW, Hung MC, Tan M. Protein lipoylation: mitochondria, cuproptosis, and beyond. Trends Biochem Sci. 2024 Aug; 49(8):729-744. PMID: 38714376.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Fu J, Ling J, Li CF, Tsai CL, Yin W, Hou J, Chen P, Cao Y, Kang Y, Sun Y, Xia X, Jiang Z, Furukawa K, Lu Y, Wu M, Huang Q, Yao J, Hawke DH, Pan BF, Zhao J, Huang J, Wang H, Bahassi EIM, Stambrook PJ, Huang P, Fleming JB, Maitra A, Tainer JA, Hung MC, Lin C, Chiao PJ. Nardilysin-regulated scission mechanism activates polo-like kinase 3 to suppress the development of pancreatic cancer. Nat Commun. 2024 Apr 11; 15(1):3149. PMID: 38605037; PMCID: PMC11009390.
      Citations:    Fields:    Translation:HumansAnimals
    11. Chen HH, Yu HI, Chang JJ, Li CW, Yang MH, Hung MC, Tarn WY. DDX3 regulates cancer immune surveillance via 3' UTR-mediated cell-surface expression of PD-L1. Cell Rep. 2024 Mar 26; 43(3):113937. PMID: 38489268.
      Citations:    Fields:    Translation:HumansCells
    12. Jabbarzadeh Kaboli P, Chen HF, Babaeizad A, Roustai Geraylow K, Yamaguchi H, Hung MC. Unlocking c-MET: A comprehensive journey into targeted therapies for breast cancer. Cancer Lett. 2024 Apr 28; 588:216780. PMID: 38462033.
      Citations:    Fields:    Translation:HumansCells
    13. Xie P, Yu M, Zhang B, Yu Q, Zhao Y, Wu M, Jin L, Yan J, Zhou B, Liu S, Li X, Zhou C, Zhu X, Huang C, Xu Y, Xiao Y, Zhou J, Fan J, Hung MC, Ye Q, Guo L, Li H, Yu Q, Wu M, Yan J. CRKL dictates anti-PD-1 resistance by mediating tumor-associated neutrophil infiltration in hepatocellular carcinoma. J Hepatol. 2024 Jul; 81(1):93-107. PMID: 38403027.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Liu C, Zhou C, Xia W, Zhou Y, Qiu Y, Weng J, Zhou Q, Chen W, Wang YN, Lee HH, Wang SC, Kuang M, Yu D, Ren N, Hung MC. Targeting ALK averts ribonuclease 1-induced immunosuppression and enhances antitumor immunity in hepatocellular carcinoma. Nat Commun. 2024 Feb 02; 15(1):1009. PMID: 38307859; PMCID: PMC10837126.
      Citations:    Fields:    Translation:HumansAnimalsCells
    15. Huang YK, Cheng WC, Kuo TT, Yang JC, Wu YC, Wu HH, Lo CC, Hsieh CY, Wong SC, Lu CH, Wu WL, Liu SJ, Li YC, Lin CC, Shen CN, Hung MC, Lin JT, Yeh CC, Sher YP. Inhibition of ADAM9 promotes the selective degradation of KRAS and sensitizes pancreatic cancers to chemotherapy. Nat Cancer. 2024 Mar; 5(3):400-419. PMID: 38267627.
      Citations:    Fields:    Translation:Humans
    16. Chen HF, Chang CT, Hsu KW, Peng PH, Lai JC, Hung MC, Wu KJ. Epigenetic regulation of asymmetric cell division by the LIBR-BRD4 axis. Nucleic Acids Res. 2024 Jan 11; 52(1):154-165. PMID: 37986225; PMCID: PMC10783485.
      Citations:    Fields:    
    17. Liu CH, Lai YL, Shen PC, Liu HC, Tsai MH, Wang YD, Lin WJ, Chen FH, Li CY, Wang SC, Hung MC, Cheng WC. DriverDBv4: a multi-omics integration database for cancer driver gene research. Nucleic Acids Res. 2024 Jan 05; 52(D1):D1246-D1252. PMID: 37956338; PMCID: PMC10767848.
      Citations:    Fields:    Translation:Humans
    18. Chang CW, Wang S, Huang J, Zeng S, Zhang X, Hung MC, Hou J. Gasdermin C sensitizes tumor cells to PARP inhibitor therapy in cancer models. J Clin Invest. 2024 Jan 02; 134(1). PMID: 37883181; PMCID: PMC10760963.
      Citations: 1     Fields:    Translation:HumansAnimals
    19. Yamaguchi H, Chang LC, Chang OS, Chen YF, Hsiao YC, Wu CS, Hung MC. MRCK as a Potential Target for Claudin-Low Subtype of Breast Cancer. Int J Biol Sci. 2024; 20(1):1-14. PMID: 38164185; PMCID: PMC10750295.
      Citations:    Fields:    Translation:HumansCells
    20. Chou WC, Chen WT, Kuo CT, Chang YM, Lu YS, Li CW, Hung MC, Shen CY. Genetic insights into carbohydrate sulfotransferase 8 and its impact on the immunotherapy efficacy of cancer. Cell Rep. 2024 01 23; 43(1):113641. PMID: 38165805.
      Citations:    Fields:    Translation:Animals
    21. Wu CS, Li YC, Peng SL, Chen CY, Chen HF, Hsueh PR, Wang WJ, Liu YY, Jiang CL, Chang WC, Wang SC, Hung MC. Coffee as a dietary strategy to prevent SARS-CoV-2 infection. Cell Biosci. 2023 Nov 14; 13(1):210. PMID: 37964389; PMCID: PMC10644613.
      Citations:    
    22. Su WC, Chen ZY, Chang YS, Jeng KS, Le UNP, Chou YC, Kuo LL, Melano I, Wang WJ, Song YC, Li SR, Hung MC, Lai MMC, Lin CW. Functional assessments of SARS-CoV-2 single-round infectious particles with variant-specific spike proteins on infectivity, drug sensitivity, and antibody neutralization. Antiviral Res. 2023 12; 220:105744. PMID: 37944823.
      Citations:    Fields:    Translation:HumansCells
    23. Dabrell SN, Li YC, Yamaguchi H, Chen HF, Hung MC. Herbal Compounds Dauricine and Isoliensinine Impede SARS-CoV-2 Viral Entry. Biomedicines. 2023 Oct 27; 11(11). PMID: 38001915; PMCID: PMC10669532.
      Citations:    
    24. Lee PC, Kumar V, Sivakumar G, Tseng TY, Li YC, Jiang YC, Hsiao YC, Lin HW, Chang CS, Hung MC. Development of triazole-based PKC-inhibitors to overcome resistance to EGFR inhibitors in EGFR-mutant lung cancers. Am J Cancer Res. 2023; 13(10):4693-4707. PMID: 37970360; PMCID: PMC10636659.
      Citations:    
    25. Koller P, Baran N, Harutyunyan K, Cavazos A, Mallampati S, Chin RL, Jiang Z, Sun X, Lee HH, Hsu JL, Williams P, Huang X, Curran MA, Hung MC, Konopleva M. PD-1 blockade in combination with dasatinib potentiates induction of anti-acute lymphocytic leukemia immunity. J Immunother Cancer. 2023 10; 11(10). PMID: 37793852; PMCID: PMC10551962.
      Citations:    Fields:    Translation:HumansAnimals
    26. Melano I, Cheng WC, Kuo LL, Liu YM, Chou YC, Hung MC, Lai MMC, Sher YP, Su WC. A disintegrin and metalloproteinase domain 9 facilitates SARS-CoV-2 entry into cells with low ACE2 expression. Microbiol Spectr. 2023 Sep 15; e0385422. PMID: 37713503; PMCID: PMC10581035.
      Citations: 1     Fields:    
    27. Yamaguchi H, Hung MC. PD-L1 and CD58 co-regulated by CMTM6 play yin and yang to shape anti-tumor immunity. Cancer Cell. 2023 Oct 09; 41(10):1701-1704. PMID: 37683640.
      Citations:    Fields:    
    28. Chen HF, Wang WJ, Chen CY, Chang WC, Hsueh PR, Peng SL, Wu CS, Chen Y, Huang HY, Shen WJ, Wang SC, Hung MC. The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2. Elife. 2023 08 29; 12. PMID: 37642993; PMCID: PMC10465125.
      Citations: 2     Fields:    Translation:HumansCells
    29. Sun X, Wang WJ, Lang J, Yang R, Shen WJ, Sun L, Hsu JM, Chan LC, Li CW, Xia W, Ke B, Yao G, Huang K, Lee PC, Koller PB, Hung MC. Inhibition of Galectin-9 sensitizes tumors to anthracycline treatment via inducing antitumor immunity. Int J Biol Sci. 2023; 19(14):4644-4656. PMID: 37781042; PMCID: PMC10535704.
      Citations: 1     Fields:    Translation:HumansAnimals
    30. Hou J, Li T, Hsu JM, Zhang X, Hung MC. Gasdermins and cancers. Semin Immunol. 2023 11; 70:101833. PMID: 37647772.
      Citations: 2     Fields:    Translation:Humans
    31. Zhang Y, Zhao Z, Huang LA, Liu Y, Yao J, Sun C, Li Y, Zhang Z, Ye Y, Yuan F, Nguyen TK, Garlapati NR, Wu A, Egranov SD, Caudle AS, Sahin AA, Lim B, Beretta L, Calin GA, Yu D, Hung MC, Curran MA, Rezvani K, Gan B, Tan Z, Han L, Lin C, Yang L. Molecular mechanisms of snoRNA-IL-15 crosstalk in adipocyte lipolysis and NK cell rejuvenation. Cell Metab. 2023 08 08; 35(8):1457-1473.e13. PMID: 37329887; PMCID: PMC10712687.
      Citations: 2     Fields:    Translation:AnimalsCells
    32. Wang YN, Lee HH, Jiang Z, Chan LC, Hortobagyi GN, Yu D, Hung MC. Ribonuclease 1 Enhances Antitumor Immunity against Breast Cancer by Boosting T cell Activation. Int J Biol Sci. 2023; 19(10):2957-2973. PMID: 37416781; PMCID: PMC10321278.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    33. Cho J, Min HY, Lee HJ, Hyun SY, Sim JY, Noh M, Hwang SJ, Park SH, Boo HJ, Lee HJ, Hong S, Park RW, Shin YK, Hung MC, Lee HY. RGS2-mediated translational control mediates cancer cell dormancy and tumor relapse. J Clin Invest. 2023 May 15; 133(10). PMID: 37183821; PMCID: PMC10178829.
      Citations: 1     Fields:    Translation:HumansCells
    34. Hong X, Hsieh MT, Tseng TY, Lin HY, Chang HC, Yau ST, Cheng WC, Liao HH, Wu CY, Liu AA, Kuo SC, Hung MC, Lee PC, Ke B, Wu MM, Huang KY, Yang PC. Diarylheptanoid 35d overcomes EGFR TKI resistance by inducing hsp70-mediated lysosomal degradation of EGFR in EGFR-mutant lung adenocarcinoma. J Biol Chem. 2023 06; 299(6):104814. PMID: 37178919; PMCID: PMC10276293.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    35. Radaram B, Glazer SE, Yang P, Li CW, Hung MC, Gammon ST, Alauddin M, Piwnica-Worms D. Evaluation of 89Zr-Labeled Anti-PD-L1 Monoclonal Antibodies Using DFO and Novel HOPO Analogues as Chelating Agents for Immuno-PET. ACS Omega. 2023 May 16; 8(19):17181-17194. PMID: 37214681; PMCID: PMC10193402.
      Citations: 1     
    36. Hao X, Shen Y, Chen N, Zhang W, Valverde E, Wu L, Chan HL, Xu Z, Yu L, Gao Y, Bado I, Michie LN, Rivas CH, Dominguez LB, Aguirre S, Pingel BC, Wu YH, Liu F, Ding Y, Edwards DG, Liu J, Alexander A, Ueno NT, Hsueh PR, Tu CY, Liu LC, Chen SH, Hung MC, Lim B, Zhang XH. Osteoprogenitor-GMP crosstalk underpins solid tumor-induced systemic immunosuppression and persists after tumor removal. Cell Stem Cell. 2023 05 04; 30(5):648-664.e8. PMID: 37146584; PMCID: PMC10165729.
      Citations: 2     Fields:    Translation:HumansCells
    37. Shie MY, Fang HY, Kan KW, Ho CC, Tu CY, Lee PC, Hsueh PR, Chen CH, Lee AK, Tien N, Chen JX, Shen YC, Chang JG, Shen YF, Lin TJ, Wang B, Hung MC, Cho DY, Chen YW. Highly Mimetic Ex Vivo Lung-Cancer Spheroid-Based Physiological Model for Clinical Precision Therapeutics. Adv Sci (Weinh). 2023 06; 10(16):e2206603. PMID: 37085943; PMCID: PMC10238206.
      Citations: 4     Fields:    Translation:HumansCells
    38. Nie L, Wang YN, Hsu JM, Hou J, Chu YY, Chan LC, Huo L, Wei Y, Deng R, Tang J, Hsu YH, Ko HW, Lim SO, Huang K, Chen MK, Chiu TJ, Cheng CC, Fang YF, Li CW, Goverdhan A, Wu HJ, Lee CC, Wang WL, Hsu J, Chiao P, Wang SC, Hung MC. Nuclear export signal mutation of epidermal growth factor receptor enhances malignant phenotypes of cancer cells. Am J Cancer Res. 2023; 13(4):1209-1239. PMID: 37168336; PMCID: PMC10164793.
      Citations: 1     
    39. Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J, Hung MC, Sood AK. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2023 03 28; 42(3). PMID: 37274180; PMCID: PMC10237679.
      Citations:    Fields:    
    40. Xu A, Liu M, Huang MF, Zhang Y, Hu R, Gingold JA, Liu Y, Zhu D, Chien CS, Wang WC, Liao Z, Yuan F, Hsu CW, Tu J, Yu Y, Rosen T, Xiong F, Jia P, Yang YP, Bazer DA, Chen YW, Li W, Huff CD, Zhu JJ, Aguilo F, Chiou SH, Boles NC, Lai CC, Hung MC, Zhao Z, Van Nostrand EL, Zhao R, Lee DF. Rewired m6A epitranscriptomic networks link mutant p53 to neoplastic transformation. Nat Commun. 2023 03 27; 14(1):1694. PMID: 36973285; PMCID: PMC10042811.
      Citations:    Fields:    Translation:Humans
    41. Wang HC, Chang WC, Lee DY, Li XG, Hung MC. IRG1/Itaconate induces metabolic reprogramming to suppress ER-positive breast cancer cell growth. Am J Cancer Res. 2023; 13(3):1067-1081. PMID: 37034222; PMCID: PMC10077032.
      Citations:    
    42. Zhou C, Weng J, Liu C, Liu S, Hu Z, Xie X, Gao D, Zhou Q, Sun J, Xu R, Li H, Shen Y, Yi Y, Shi Y, Sheng X, Dong Q, Hung MC, Ren N. Disruption of SLFN11 Deficiency-Induced CCL2 Signaling and Macrophage M2 Polarization Potentiates Anti-PD-1 Therapy Efficacy in Hepatocellular Carcinoma. Gastroenterology. 2023 06; 164(7):1261-1278. PMID: 36863689.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    43. Liu H, Ou J, Hung MC, Chen X. Immune checkpoint blockades therapy of melanoma. Sci Bull (Beijing). 2023 02 26; 68(4):356-358. PMID: 36774302.
      Citations:    Fields:    Translation:Humans
    44. Sun C, Ye Y, Tan Z, Liu Y, Li Y, Hu W, Liang K, Egranov SD, Huang LA, Zhang Z, Zhang Y, Yao J, Nguyen TK, Zhao Z, Wu A, Marks JR, Caudle AS, Sahin AA, Gao J, Gammon ST, Piwnica-Worms D, Hu J, Chiao PJ, Yu D, Hung MC, Curran MA, Calin GA, Ying H, Han L, Lin C, Yang L. Tumor-associated nonmyelinating Schwann cell-expressed PVT1 promotes pancreatic cancer kynurenine pathway and tumor immune exclusion. Sci Adv. 2023 02 03; 9(5):eadd6995. PMID: 36724291; PMCID: PMC9891701.
      Citations: 5     Fields:    Translation:HumansCells
    45. Zheng S, Song J, Linghu D, Yang R, Liu B, Xue Z, Chen Q, Liu C, Zhong D, Hung MC, Sun L. Galectin-9 blockade synergizes with ATM inhibition to induce potent anti-tumor immunity. Int J Biol Sci. 2023; 19(3):981-993. PMID: 36778120; PMCID: PMC9909994.
      Citations: 1     Fields:    Translation:HumansAnimals
    46. Lin ZS, Chung CC, Liu YC, Chang CH, Liu HC, Liang YY, Huang TL, Chen TM, Lee CH, Tang CH, Hung MC, Chen YH. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression. Elife. 2023 01 09; 12. PMID: 36622753; PMCID: PMC9829410.
      Citations: 1     Fields:    
    47. Hou J, Wang S, Miao R, Zhang X, Hung MC. Detection of Gasdermin C-Mediated Cancer Cell Pyroptosis. Methods Mol Biol. 2023; 2641:135-146. PMID: 37074647.
      Citations:    Fields:    
    48. Hsieh CY, Chang WC, Lin CC, Chen JH, Lin CY, Liu CH, Lin C, Hung MC. Combination treatment of arsenic trioxide and osimertinib in recurrent and metastatic head and neck squamous cell carcinoma. Am J Cancer Res. 2022; 12(11):5049-5061. PMID: 36504903; PMCID: PMC9729903.
      Citations:    
    49. Zhang Y, Sun C, Li Y, Qin J, Amancherla K, Jing Y, Hu Q, Liang K, Zhang Z, Ye Y, Huang LA, Nguyen TK, Egranov SD, Zhao Z, Wu A, Xi Y, Yao J, Hung MC, Calin GA, Cheng J, Lim B, Lehmann LH, Salem JE, Johnson DB, Curran MA, Yu D, Han L, Darabi R, Yang L, Moslehi JJ, Lin C. Hormonal therapies up-regulate MANF and overcome female susceptibility to immune checkpoint inhibitor myocarditis. Sci Transl Med. 2022 11 02; 14(669):eabo1981. PMID: 36322628; PMCID: PMC9809130.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    50. Chu YY, Yam C, Yamaguchi H, Hung MC. Biomarkers beyond BRCA: promising combinatorial treatment strategies in overcoming resistance to PARP inhibitors. J Biomed Sci. 2022 Oct 25; 29(1):86. PMID: 36284291; PMCID: PMC9594904.
      Citations: 1     Fields:    Translation:Humans
    51. Chu YY, Chen MK, Wei Y, Lee HH, Xia W, Wang YN, Yam C, Hsu JL, Wang HL, Chang WC, Yamaguchi H, Jiang Z, Liu C, Li CF, Nie L, Chan LC, Gao Y, Wang SC, Liu J, Westin SN, Lee S, Sood AK, Yang L, Hortobagyi GN, Yu D, Hung MC. Targeting the ALK-CDK9-Tyr19 kinase cascade sensitizes ovarian and breast tumors to PARP inhibition via destabilization of the P-TEFb complex. Nat Cancer. 2022 10; 3(10):1211-1227. PMID: 36253486; PMCID: PMC9586872.
      Citations: 1     Fields:    Translation:HumansAnimals
    52. Wang SH, Chou WC, Huang HC, Lee TA, Hsiao TC, Wang LH, Huang KB, Kuo CT, Chao CH, Chang SJ, Hsu JM, Weng J, Ren N, Li FA, Lai YJ, Zhou C, Hung MC, Li CW. Deglycosylation of SLAMF7 in breast cancers enhances phagocytosis. Am J Cancer Res. 2022; 12(10):4721-4736. PMID: 36381324; PMCID: PMC9641385.
      Citations: 1     
    53. Li YC, Yamaguchi H, Liu YY, Hsu KC, Sun TH, Sun PC, Hung MC. Structural insights into EphA4 unconventional activation from prediction of the EphA4 and its complex with ribonuclease 1. Am J Cancer Res. 2022; 12(10):4865-4878. PMID: 36381327; PMCID: PMC9641407.
      Citations: 1     
    54. Mei Y, Hang Q, Teng H, Yao F, Chen MK, Hung MC, Sun Y, Ma L. ZRANB1 is an NBS1 deubiquitinase and a potential target to overcome radioresistance and PARP inhibitor resistance in triple-negative breast cancer. Genes Dis. 2023 Sep; 10(5):1739-1742. PMID: 37492703; PMCID: PMC10363626.
      Citations:    
    55. Zhou Q, Yin Y, Yu M, Gao D, Sun J, Yang Z, Weng J, Chen W, Atyah M, Shen Y, Ye Q, Li CW, Hung MC, Dong Q, Zhou C, Ren N. GTPBP4 promotes hepatocellular carcinoma progression and metastasis via the PKM2 dependent glucose metabolism. Redox Biol. 2022 10; 56:102458. PMID: 36116159; PMCID: PMC9483790.
      Citations:    
    56. Lau P, Zhang G, Zhao S, Liang L, Zhang H, Zhou G, Hung MC, Chen X, Liu H. Sphingosine kinase 1 promotes tumor immune evasion by regulating the MTA3-PD-L1 axis. Cell Mol Immunol. 2022 10; 19(10):1153-1167. PMID: 36050478; PMCID: PMC9508236.
      Citations:    
    57. Wang YL, Zhao WW, Bai SM, Ma Y, Yin XK, Feng LL, Zeng GD, Wang F, Feng WX, Zheng J, Wang YN, Zeng B, Liu Q, Hung MC, Wan XB. DNA damage-induced paraspeckle formation enhances DNA repair and tumor radioresistance by recruiting ribosomal protein P0. Cell Death Dis. 2022 08 16; 13(8):709. PMID: 35974014; PMCID: PMC9381602.
      Citations:    
    58. Ho CT, Lin SP, Tseng LM, Hung MC, Hung SC. Snail induces dormancy in disseminated luminal type A breast cancer through Src inhibition. Am J Cancer Res. 2022; 12(8):3932-3946. PMID: 36119827; PMCID: PMC9442010.
      Citations:    
    59. Wang WJ, Chen Y, Su WC, Liu YY, Shen WJ, Chang WC, Huang ST, Lin CW, Wang YC, Yang CS, Hou MH, Chou YC, Wu YC, Wang SC, Hung MC. Peimine inhibits variants of SARS-CoV-2 cell entry via blocking the interaction between viral spike protein and ACE2. J Food Biochem. 2022 10; 46(10):e14354. PMID: 35894128; PMCID: PMC9353385.
      Citations:    Fields:    
    60. Chen HF, Hsueh PR, Liu YY, Chen Y, Chang SY, Wang WJ, Wu CS, Tsai YM, Liu YS, Su WC, Chou YC, Hung MC. Disulfiram blocked cell entry of SARS-CoV-2 via inhibiting the interaction of spike protein and ACE2. Am J Cancer Res. 2022; 12(7):3333-3346. PMID: 35968340; PMCID: PMC9360250.
      Citations:    
    61. Wu CS, Chiang HM, Chen Y, Chen CY, Chen HF, Su WC, Wang WJ, Chou YC, Chang WC, Wang SC, Hung MC. Prospects of Coffee Leaf against SARS-CoV-2 Infection. Int J Biol Sci. 2022; 18(12):4677-4689. PMID: 35874948; PMCID: PMC9305275.
      Citations:    Fields:    Translation:AnimalsCells
    62. Wang SC, Chou IW, Hung MC. Natural tannins as anti-SARS-CoV-2 compounds. Int J Biol Sci. 2022; 18(12):4669-4676. PMID: 35874955; PMCID: PMC9305278.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    63. Yen JH, Huang WC, Lin SC, Huang YW, Chio WT, Tsay GJ, Hung MC, Huang ST. Metabolic remodeling in tumor-associated macrophages contributing to antitumor activity of cryptotanshinone by regulating TRAF6-ASK1 axis. Mol Ther Oncolytics. 2022 Sep 15; 26:158-174. PMID: 35860009; PMCID: PMC9271981.
      Citations:    
    64. Wen Y, Chelariu-Raicu A, Umamaheswaran S, Nick AM, Stur E, Hanjra P, Jiang D, Jennings NB, Chen X, Corvigno S, Glassman D, Lopez-Berestein G, Liu J, Hung MC, Sood AK. Endothelial p130cas confers resistance to anti-angiogenesis therapy. Cell Rep. 2022 Jun 21; 39(12):110999. PMID: 35732127; PMCID: PMC9272813.
      Citations:    Fields:    
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    188. Wang Y, Li N, Jiang W, Deng W, Ye R, Xu C, Qiao Y, Sharma A, Zhang M, Hung MC, Lin SH. Mutant LKB1 Confers Enhanced Radiosensitization in Combination with Trametinib in KRAS-Mutant Non-Small Cell Lung Cancer. Clin Cancer Res. 2018 11 15; 24(22):5744-5756. PMID: 30068711.
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    192. Yang Y, Li CW, Chan LC, Wei Y, Hsu JM, Xia W, Cha JH, Hou J, Hsu JL, Sun L, Hung MC. Exosomal PD-L1 harbors active defense function to suppress T cell killing of breast cancer cells and promote tumor growth. Cell Res. 2018 08; 28(8):862-864. PMID: 29959401; PMCID: PMC6082826.
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    194. Yang WH, Cha JH, Xia W, Lee HH, Chan LC, Wang YN, Hsu JL, Ren G, Hung MC. Juxtacrine Signaling Inhibits Antitumor Immunity by Upregulating PD-L1 Expression. Cancer Res. 2018 07 15; 78(14):3761-3768. PMID: 29789418; PMCID: PMC6050079.
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    195. Hsu JM, Xia W, Hsu YH, Chan LC, Yu WH, Cha JH, Chen CT, Liao HW, Kuo CW, Khoo KH, Hsu JL, Li CW, Lim SO, Chang SS, Chen YC, Ren GX, Hung MC. STT3-dependent PD-L1 accumulation on cancer stem cells promotes immune evasion. Nat Commun. 2018 05 15; 9(1):1908. PMID: 29765039; PMCID: PMC5954021.
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    198. Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, Lawhon SE, Siverly AN, Su X, Li J, Xie X, Cheng X, Liu LC, Chang HW, Chiang SF, Lopez-Berestein G, Sood AK, Chen J, You MJ, Sun SC, Liang H, Huang Y, Yang X, Sun D, Sun Y, Hung MC, Ma L. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Rep. 2018 Apr 17; 23(3):823-837. PMID: 29669287; PMCID: PMC5933875.
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    200. Chen YH, Chung CC, Liu YC, Lai WC, Lin ZS, Chen TM, Li LY, Hung MC. YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts. Am J Cancer Res. 2018; 8(3):514-525. PMID: 29637005; PMCID: PMC5883100.
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    201. Li CW, Lim SO, Chung EM, Kim YS, Park AH, Yao J, Cha JH, Xia W, Chan LC, Kim T, Chang SS, Lee HH, Chou CK, Liu YL, Yeh HC, Perillo EP, Dunn AK, Kuo CW, Khoo KH, Hsu JL, Wu Y, Hsu JM, Yamaguchi H, Huang TH, Sahin AA, Hortobagyi GN, Yoo SS, Hung MC. Eradication of Triple-Negative Breast Cancer Cells by Targeting Glycosylated PD-L1. Cancer Cell. 2018 02 12; 33(2):187-201.e10. PMID: 29438695; PMCID: PMC5824730.
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    202. Zhou R, Xu A, Wang D, Zhu D, Mata H, Huo Z, Tu J, Liu M, Mohamed AMT, Jewell BE, Gingold J, Xia W, Rao PH, Hung MC, Zhao R, Lee DF. A homozygous p53 R282W mutant human embryonic stem cell line generated using TALEN-mediated precise gene editing. Stem Cell Res. 2018 03; 27:131-135. PMID: 29414603.
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    205. Lai HH, Li JN, Wang MY, Huang HY, Croce CM, Sun HL, Lyu YJ, Kang JW, Chiu CF, Hung MC, Suzuki HI, Chen PS. HIF-1a promotes autophagic proteolysis of Dicer and enhances tumor metastasis. J Clin Invest. 2018 02 01; 128(2):625-643. PMID: 29251629; PMCID: PMC5785260.
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    208. Wang S, Liang K, Hu Q, Li P, Song J, Yang Y, Yao J, Mangala LS, Li C, Yang W, Park PK, Hawke DH, Zhou J, Zhou Y, Xia W, Hung MC, Marks JR, Gallick GE, Lopez-Berestein G, Flores ER, Sood AK, Huang S, Yu D, Yang L, Lin C. JAK2-binding long noncoding RNA promotes breast cancer brain metastasis. J Clin Invest. 2017 12 01; 127(12):4498-4515. PMID: 29130936; PMCID: PMC5707156.
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    210. Lin X, Chen W, Wei F, Zhou BP, Hung MC, Xie X. Nanoparticle Delivery of miR-34a Eradicates Long-term-cultured Breast Cancer Stem Cells via Targeting C22ORF28 Directly. Theranostics. 2017; 7(19):4805-4824. PMID: 29187905; PMCID: PMC5706101.
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    211. Hossain MB, Shifat R, Li J, Luo X, Hess KR, Rivera-Molina Y, Puerta Martinez F, Jiang H, Lang FF, Hung MC, Fueyo J, Gomez-Manzano C. TIE2 Associates with Caveolae and Regulates Caveolin-1 To Promote Their Nuclear Translocation. Mol Cell Biol. 2017 Nov 01; 37(21). PMID: 28760776; PMCID: PMC5640814.
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    212. Yang R, Hung MC. The role of T-cell immunoglobulin mucin-3 and its ligand galectin-9 in antitumor immunity and cancer immunotherapy. Sci China Life Sci. 2017 Oct; 60(10):1058-1064. PMID: 29027155.
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    217. Nakai K, Xia W, Liao HW, Saito M, Hung MC, Yamaguchi H. The role of PRMT1 in EGFR methylation and signaling in MDA-MB-468 triple-negative breast cancer cells. Breast Cancer. 2018 Jan; 25(1):74-80. PMID: 28643125.
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    251. Chang TY, Chen HA, Chiu CF, Chang YW, Kuo TC, Tseng PC, Wang W, Hung MC, Su JL. Dicer Elicits Paclitaxel Chemosensitization and Suppresses Cancer Stemness in Breast Cancer by Repressing AXL. Cancer Res. 2016 07 01; 76(13):3916-28. PMID: 27216190.
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    252. Chou CK, Fan CC, Lin PS, Liao PY, Tung JC, Hsieh CH, Hung MC, Chen CH, Chang WC. Sciellin mediates mesenchymal-to-epithelial transition in colorectal cancer hepatic metastasis. Oncotarget. 2016 May 03; 7(18):25742-54. PMID: 27013588; PMCID: PMC5041940.
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    253. Wu SY, Rupaimoole R, Shen F, Pradeep S, Pecot CV, Ivan C, Nagaraja AS, Gharpure KM, Pham E, Hatakeyama H, McGuire MH, Haemmerle M, Vidal-Anaya V, Olsen C, Rodriguez-Aguayo C, Filant J, Ehsanipour EA, Herbrich SM, Maiti SN, Huang L, Kim JH, Zhang X, Han HD, Armaiz-Pena GN, Seviour EG, Tucker S, Zhang M, Yang D, Cooper LJ, Ali-Fehmi R, Bar-Eli M, Lee JS, Ram PT, Baggerly KA, Lopez-Berestein G, Hung MC, Sood AK. A miR-192-EGR1-HOXB9 regulatory network controls the angiogenic switch in cancer. Nat Commun. 2016 Apr 04; 7:11169. PMID: 27041221; PMCID: PMC4822037.
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    254. Yao J, Huang Y, Lin C, Rimoldi D, Behren A, Cebon JS, Hung MC, Weinstein JN, Strausberg RL, Zhao Q, Caballero OL. Altered Expression and Splicing of ESRP1 in Malignant Melanoma Correlates with Epithelial-Mesenchymal Status and Tumor-Associated Immune Cytolytic Activity. Cancer Immunol Res. 2016 06; 4(6):552-61. PMID: 27045022.
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    255. Chou CK, Tsou PH, Hsu JL, Lee HH, Wang YN, Kameoka J, Hung MC. Analysis of Individual Signaling Complexes by mMAPS, a Flow-Proteometric System. Curr Protoc Mol Biol. 2016 Apr 01; 114:20.11.1-20.11.22. PMID: 27038387; PMCID: PMC4830480.
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    256. Hossain MB, Shifat R, Johnson DG, Bedford MT, Gabrusiewicz KR, Cortes-Santiago N, Luo X, Lu Z, Ezhilarasan R, Sulman EP, Jiang H, Li SS, Lang FF, Tyler J, Hung MC, Fueyo J, Gomez-Manzano C. TIE2-mediated tyrosine phosphorylation of H4 regulates DNA damage response by recruiting ABL1. Sci Adv. 2016 04; 2(4):e1501290. PMID: 27757426; PMCID: PMC5065225.
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    257. Chen MK, Hung MC. Regulation of therapeutic resistance in cancers by receptor tyrosine kinases. Am J Cancer Res. 2016; 6(4):827-42. PMID: 27186434; PMCID: PMC4859887.
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    258. Hsu MC, Hung WC, Yamaguchi H, Lim SO, Liao HW, Tsai CH, Hung MC. Extracellular PKM2 induces cancer proliferation by activating the EGFR signaling pathway. Am J Cancer Res. 2016; 6(3):628-38. PMID: 27152240; PMCID: PMC4851842.
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    259. Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Liu B, Shi Q, Lam EW, Hung MC, Liu Q. Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype. Nat Commun. 2016 Jan 19; 7:10180. PMID: 26782714; PMCID: PMC4735655.
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    260. Du Y, Yamaguchi H, Wei Y, Hsu JL, Wang HL, Hsu YH, Lin WC, Yu WH, Leonard PG, Lee GR, Chen MK, Nakai K, Hsu MC, Chen CT, Sun Y, Wu Y, Chang WC, Huang WC, Liu CL, Chang YC, Chen CH, Park M, Jones P, Hortobagyi GN, Hung MC. Blocking c-Met-mediated PARP1 phosphorylation enhances anti-tumor effects of PARP inhibitors. Nat Med. 2016 Feb; 22(2):194-201. PMID: 26779812; PMCID: PMC4754671.
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    261. Li CW, Xia W, Lim SO, Hsu JL, Huo L, Wu Y, Li LY, Lai CC, Chang SS, Hsu YH, Sun HL, Kim J, Yamaguchi H, Lee DF, Wang H, Wang Y, Chou CK, Hsu JM, Lai YJ, LaBaff AM, Ding Q, Ko HW, Tsai FJ, Tsai CH, Hortobagyi GN, Hung MC. AKT1 Inhibits Epithelial-to-Mesenchymal Transition in Breast Cancer through Phosphorylation-Dependent Twist1 Degradation. Cancer Res. 2016 Mar 15; 76(6):1451-62. PMID: 26759241; PMCID: PMC4794388.
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    262. Lim SO, Li CW, Xia W, Lee HH, Chang SS, Shen J, Hsu JL, Raftery D, Djukovic D, Gu H, Chang WC, Wang HL, Chen ML, Huo L, Chen CH, Wu Y, Sahin A, Hanash SM, Hortobagyi GN, Hung MC. EGFR Signaling Enhances Aerobic Glycolysis in Triple-Negative Breast Cancer Cells to Promote Tumor Growth and Immune Escape. Cancer Res. 2016 Mar 01; 76(5):1284-96. PMID: 26759242; PMCID: PMC4775355.
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    263. Wang C, Hu Z, Lin A, Li C, Xing Z, Hu Q, Liang K, Han L, Hawke DH, Wang S, Zhang Y, Wei Y, Ma G, Park PK, Zhou J, Zhou Y, Zhou Y, Marks JR, Liang H, Hung MC, Lin C, Yang L. The LINK-A lncRNA activates normoxic HIF1a signalling in triple-negative breast cancer. Nat Cell Biol. 2016 Feb; 18(2):213-24. PMID: 26751287; PMCID: PMC4791069.
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    264. Li N, Dhar SS, Chen TY, Kan PY, Wei Y, Kim JH, Chan CH, Lin HK, Hung MC, Lee MG. JARID1D Is a Suppressor and Prognostic Marker of Prostate Cancer Invasion and Metastasis. Cancer Res. 2016 Feb 15; 76(4):831-43. PMID: 26747897; PMCID: PMC4755879.
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    265. Wu TJ, Chang SS, Li CW, Hsu YH, Chen TC, Lee WC, Yeh CT, Hung MC. Severe Hepatitis Promotes Hepatocellular Carcinoma Recurrence via NF-?B Pathway-Mediated Epithelial-Mesenchymal Transition after Resection. Clin Cancer Res. 2016 Apr 01; 22(7):1800-12. PMID: 26655845; PMCID: PMC4818680.
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    266. Liao HW, Hsu JM, Xia W, Wang HL, Wang YN, Chang WC, Arold ST, Chou CK, Tsou PH, Yamaguchi H, Fang YF, Lee HJ, Lee HH, Tai SK, Yang MH, Morelli MP, Sen M, Ladbury JE, Chen CH, Grandis JR, Kopetz S, Hung MC. PRMT1-mediated methylation of the EGF receptor regulates signaling and cetuximab response. J Clin Invest. 2015 Dec; 125(12):4529-43. PMID: 26571401; PMCID: PMC4665782.
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    267. Lukianova-Hleb EY, Kim YS, Aryasomayajula B, Boulikas T, Phan J, Hung MC, Torchilin VP, O'Neill BE, Lapotko DO. Safety and efficacy of quadrapeutics versus chemoradiation in head and neck carcinoma xenograft model. Am J Cancer Res. 2015; 5(12):3534-47. PMID: 26885444; PMCID: PMC4731629.
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    268. Chen CT, Chen YC, Yamaguchi H, Hung MC. Carglumic acid promotes apoptosis and suppresses cancer cell proliferation in vitro and in vivo. Am J Cancer Res. 2015; 5(12):3560-9. PMID: 26885446; PMCID: PMC4731631.
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    269. Rahal OM, Nie L, Chan LC, Li CW, Hsu YH, Hsu J, Yu D, Hung MC. Selective expression of constitutively active pro-apoptotic protein BikDD gene in primary mammary tumors inhibits tumor growth and reduces tumor initiating cells. Am J Cancer Res. 2015; 5(12):3624-34. PMID: 26885451; PMCID: PMC4731636.
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    270. Han B, Qu Y, Jin Y, Yu Y, Deng N, Wawrowsky K, Zhang X, Li N, Bose S, Wang Q, Sakkiah S, Abrol R, Jensen TW, Berman BP, Tanaka H, Johnson J, Gao B, Hao J, Liu Z, Buttyan R, Ray PS, Hung MC, Giuliano AE, Cui X. FOXC1 Activates Smoothened-Independent Hedgehog Signaling in Basal-like Breast Cancer. Cell Rep. 2015 Nov 03; 13(5):1046-58. PMID: 26565916; PMCID: PMC4806384.
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    271. Pradeep S, Huang J, Mora EM, Nick AM, Cho MS, Wu SY, Noh K, Pecot CV, Rupaimoole R, Stein MA, Brock S, Wen Y, Xiong C, Gharpure K, Hansen JM, Nagaraja AS, Previs RA, Vivas-Mejia P, Han HD, Hu W, Mangala LS, Zand B, Stagg LJ, Ladbury JE, Ozpolat B, Alpay SN, Nishimura M, Stone RL, Matsuo K, Dalton HJ, Danes C, Goodman B, Rodriguez-Aguayo C, Kruger C, Schneider A, Haghpeykar S, Jaladurgam P, Hung MC, Coleman RL, Liu J, Li C, Urbauer D, Lopez-Berestein G, Jackson DB, Sood AK, Armaiz-Pe?a GN. Erythropoietin Stimulates Tumor Growth via EphB4. Cancer Cell. 2015 Nov 09; 28(5):610-622. PMID: 26481148; PMCID: PMC4643364.
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    272. Yang PW, Chiang TH, Hsieh CY, Huang YC, Wong LF, Hung MC, Tsai JC, Lee JM. The effect of ephrin-A1 on resistance to Photofrin-mediated photodynamic therapy in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2015 Dec; 30(9):2353-61. PMID: 26450615.
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    273. Hu D, Gur M, Zhou Z, Gamper A, Hung MC, Fujita N, Lan L, Bahar I, Wan Y. Interplay between arginine methylation and ubiquitylation regulates KLF4-mediated genome stability and carcinogenesis. Nat Commun. 2015 Sep 30; 6:8419. PMID: 26420673; PMCID: PMC4598737.
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    274. Chen WS, Yen CJ, Chen YJ, Chen JY, Wang LY, Chiu SJ, Shih WL, Ho CY, Wei TT, Pan HL, Chien PH, Hung MC, Chen CC, Huang WC. miRNA-7/21/107 contribute to HBx-induced hepatocellular carcinoma progression through suppression of maspin. Oncotarget. 2015 Sep 22; 6(28):25962-74. PMID: 26296971; PMCID: PMC4694878.
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    275. Lee HH, Wang YN, Hung MC. Non-canonical signaling mode of the epidermal growth factor receptor family. Am J Cancer Res. 2015; 5(10):2944-58. PMID: 26693051; PMCID: PMC4656722.
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    276. Dai HY, Chen HY, Lai WC, Hung MC, Li LY. Targeted expression of BikDD combined with metronomic doxorubicin induces synergistic antitumor effect through Bax activation in hepatocellular carcinoma. Oncotarget. 2015 Sep 15; 6(27):23807-19. PMID: 26247632; PMCID: PMC4695153.
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    277. Perillo EP, Liu YL, Huynh K, Liu C, Chou CK, Hung MC, Yeh HC, Dunn AK. Deep and high-resolution three-dimensional tracking of single particles using nonlinear and multiplexed illumination. Nat Commun. 2015 Jul 29; 6:7874. PMID: 26219252; PMCID: PMC4532916.
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    278. Timsah Z, Ahmed Z, Ivan C, Berrout J, Gagea M, Zhou Y, Pena GN, Hu X, Vallien C, Kingsley CV, Lu Y, Hancock JF, Liu J, Gladden AB, Mills GB, Lopez-Berestein G, Hung MC, Sood AK, Bogdanov M, Ladbury JE. Grb2 depletion under non-stimulated conditions inhibits PTEN, promotes Akt-induced tumor formation and contributes to poor prognosis in ovarian cancer. Oncogene. 2016 04 28; 35(17):2186-96. PMID: 26212011; PMCID: PMC4792786.
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    279. Chen MK, Hung MC. Proteolytic cleavage, trafficking, and functions of nuclear receptor tyrosine kinases. FEBS J. 2015 Oct; 282(19):3693-721. PMID: 26096795; PMCID: PMC4591179.
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    280. Aslan B, Monroig P, Hsu MC, Pena GA, Rodriguez-Aguayo C, Gonzalez-Villasana V, Rupaimoole R, Nagaraja AS, Mangala S, Han HD, Yuca E, Wu SY, Ivan C, Moss TJ, Ram PT, Wang H, Gol-Chambers A, Ozkayar O, Kanlikilicer P, Fuentes-Mattei E, Kahraman N, Pradeep S, Ozpolat B, Tucker S, Hung MC, Baggerly K, Bartholomeusz G, Calin G, Sood AK, Lopez-Berestein G. The ZNF304-integrin axis protects against anoikis in cancer. Nat Commun. 2015 Jun 17; 6:7351. PMID: 26081979; PMCID: PMC4830335.
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    281. Yang CC, LaBaff A, Wei Y, Nie L, Xia W, Huo L, Yamaguchi H, Hsu YH, Hsu JL, Liu D, Lang J, Du Y, Lien HC, Li LY, Deng R, Chan LC, Yao J, Kleer CG, Hortobagyi GN, Hung MC. Phosphorylation of EZH2 at T416 by CDK2 contributes to the malignancy of triple negative breast cancers. Am J Transl Res. 2015; 7(6):1009-20. PMID: 26279746; PMCID: PMC4532735.
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    282. Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Res. 2015 May 01; 75(9):1846-58. PMID: 25877877; PMCID: PMC4417433.
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    283. Lee DF, Su J, Kim HS, Chang B, Papatsenko D, Zhao R, Yuan Y, Gingold J, Xia W, Darr H, Mirzayans R, Hung MC, Schaniel C, Lemischka IR. Modeling familial cancer with induced pluripotent stem cells. Cell. 2015 Apr 09; 161(2):240-54. PMID: 25860607; PMCID: PMC4397979.
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    284. Zuo M, Rashid A, Churi C, Vauthey JN, Chang P, Li Y, Hung MC, Li D, Javle M. Novel therapeutic strategy targeting the Hedgehog signalling and mTOR pathways in biliary tract cancer. Br J Cancer. 2015 Mar 17; 112(6):1042-51. PMID: 25742482; PMCID: PMC4366884.
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    285. Song S, Honjo S, Jin J, Chang SS, Scott AW, Chen Q, Kalhor N, Correa AM, Hofstetter WL, Albarracin CT, Wu TT, Johnson RL, Hung MC, Ajani JA. The Hippo Coactivator YAP1 Mediates EGFR Overexpression and Confers Chemoresistance in Esophageal Cancer. Clin Cancer Res. 2015 Jun 01; 21(11):2580-90. PMID: 25739674; PMCID: PMC4452384.
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    286. Sun Y, Ponz-Sarvise M, Chang SS, Chang WC, Chen CH, Hsu JL, Hung MC. Proteasome inhibition enhances the killing effect of BikDD gene therapy. Am J Transl Res. 2015; 7(2):319-27. PMID: 25901200; PMCID: PMC4399095.
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    287. Xu J, Acharya S, Sahin O, Zhang Q, Saito Y, Yao J, Wang H, Li P, Zhang L, Lowery FJ, Kuo WL, Xiao Y, Ensor J, Sahin AA, Zhang XH, Hung MC, Zhang JD, Yu D. 14-3-3? turns TGF-?'s function from tumor suppressor to metastasis promoter in breast cancer by contextual changes of Smad partners from p53 to Gli2. Cancer Cell. 2015 Feb 09; 27(2):177-92. PMID: 25670079; PMCID: PMC4325275.
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    288. Shen J, Hung MC. Signaling-mediated regulation of MicroRNA processing. Cancer Res. 2015 Mar 01; 75(5):783-91. PMID: 25660948; PMCID: PMC4348149.
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    289. Lee HJ, Lan L, Peng G, Chang WC, Hsu MC, Wang YN, Cheng CC, Wei L, Nakajima S, Chang SS, Liao HW, Chen CH, Lavin M, Ang KK, Lin SY, Hung MC. Tyrosine 370 phosphorylation of ATM positively regulates DNA damage response. Cell Res. 2015 Feb; 25(2):225-36. PMID: 25601159; PMCID: PMC4650576.
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    290. Wang YN, Huo L, Hsu JL, Hung MC. Biochemical fractionation of membrane receptors in the nucleus. Methods Mol Biol. 2015; 1234:99-112. PMID: 25304351.
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    291. Huo L, Li CW, Huang TH, Lam YC, Xia W, Tu C, Chang WC, Hsu JL, Lee DF, Nie L, Yamaguchi H, Wang Y, Lang J, Li LY, Chen CH, Mishra L, Hung MC. Activation of Keap1/Nrf2 signaling pathway by nuclear epidermal growth factor receptor in cancer cells. Am J Transl Res. 2014; 6(6):649-63. PMID: 25628777; PMCID: PMC4297334.
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    292. Chang YW, Chen HA, Tseng CF, Hong CC, Ma JT, Hung MC, Wu CH, Huang MT, Su JL. De-acetylation and degradation of HSPA5 is critical for E1A metastasis suppression in breast cancer cells. Oncotarget. 2014 Nov 15; 5(21):10558-70. PMID: 25301734; PMCID: PMC4279393.
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    293. Xing Z, Lin A, Li C, Liang K, Wang S, Liu Y, Park PK, Qin L, Wei Y, Hawke DH, Hung MC, Lin C, Yang L. lncRNA directs cooperative epigenetic regulation downstream of chemokine signals. Cell. 2014 Nov 20; 159(5):1110-1125. PMID: 25416949; PMCID: PMC4266991.
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    294. Boulbes DR, Arold ST, Chauhan GB, Blachno KV, Deng N, Chang WC, Jin Q, Huang TH, Hsu JM, Brady SW, Bartholomeusz C, Ladbury JE, Stone S, Yu D, Hung MC, Esteva FJ. HER family kinase domain mutations promote tumor progression and can predict response to treatment in human breast cancer. Mol Oncol. 2015 Mar; 9(3):586-600. PMID: 25435280; PMCID: PMC4815926.
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    295. Chen HA, Chang YW, Tseng CF, Chiu CF, Hong CC, Wang W, Wang MY, Hsiao M, Ma JT, Chen CH, Jiang SS, Wu CH, Hung MC, Huang MT, Su JL. E1A-mediated inhibition of HSPA5 suppresses cell migration and invasion in triple-negative breast cancer. Ann Surg Oncol. 2015 Mar; 22(3):889-98. PMID: 25212833.
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    296. Hong CC, Chen PS, Chiou J, Chiu CF, Yang CY, Hsiao M, Chang YW, Yu YH, Hung MC, Hsu NW, Shiah SG, Hsu NY, Su JL. miR326 maturation is crucial for VEGF-C-driven cortactin expression and esophageal cancer progression. Cancer Res. 2014 Nov 01; 74(21):6280-90. PMID: 25205106.
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    297. Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, Ang KK, Hung MC, Chen J, Ma L. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nat Cell Biol. 2014 Sep; 16(9):864-75. PMID: 25086746; PMCID: PMC4150825.
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    298. Thirumurthi U, Shen J, Xia W, LaBaff AM, Wei Y, Li CW, Chang WC, Chen CH, Lin HK, Yu D, Hung MC. MDM2-mediated degradation of SIRT6 phosphorylated by AKT1 promotes tumorigenesis and trastuzumab resistance in breast cancer. Sci Signal. 2014 Jul 29; 7(336):ra71. PMID: 25074979; PMCID: PMC4161976.
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    299. Chou RH, Wang YN, Hsieh YH, Li LY, Xia W, Chang WC, Chang LC, Cheng CC, Lai CC, Hsu JL, Chang WJ, Chiang SY, Lee HJ, Liao HW, Chuang PH, Chen HY, Wang HL, Kuo SC, Chen CH, Yu YL, Hung MC. EGFR modulates DNA synthesis and repair through Tyr phosphorylation of histone H4. Dev Cell. 2014 Jul 28; 30(2):224-37. PMID: 25073158; PMCID: PMC4149291.
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    300. Lin CY, Chen HJ, Huang CC, Lai LC, Lu TP, Tseng GC, Kuo TT, Kuok QY, Hsu JL, Sung SY, Hung MC, Sher YP. ADAM9 promotes lung cancer metastases to brain by a plasminogen activator-based pathway. Cancer Res. 2014 Sep 15; 74(18):5229-43. PMID: 25060522.
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    301. Debeb BG, Gong Y, Atkinson RL, Sneige N, Huo L, Gonzalez-Angulo AM, Hung MC, Valero V, Ueno NT, Woodward WA. EZH2 expression correlates with locoregional recurrence after radiation in inflammatory breast cancer. J Exp Clin Cancer Res. 2014 Jul 23; 33:58. PMID: 25051981; PMCID: PMC4431485.
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    302. Khotskaya YB, Goverdhan A, Shen J, Ponz-Sarvise M, Chang SS, Hsu MC, Wei Y, Xia W, Yu D, Hung MC. S6K1 promotes invasiveness of breast cancer cells in a model of metastasis of triple-negative breast cancer. Am J Transl Res. 2014; 6(4):361-76. PMID: 25075253; PMCID: PMC4113498.
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    303. Yamaguchi H, Hung MC. Regulation and Role of EZH2 in Cancer. Cancer Res Treat. 2014 Jul; 46(3):209-22. PMID: 25038756; PMCID: PMC4132442.
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    304. Hsu YH, Yao J, Chan LC, Wu TJ, Hsu JL, Fang YF, Wei Y, Wu Y, Huang WC, Liu CL, Chang YC, Wang MY, Li CW, Shen J, Chen MK, Sahin AA, Sood A, Mills GB, Yu D, Hortobagyi GN, Hung MC. Definition of PKC-a, CDK6, and MET as therapeutic targets in triple-negative breast cancer. Cancer Res. 2014 Sep 01; 74(17):4822-35. PMID: 24970481; PMCID: PMC4154991.
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    305. Chao CH, Chang CC, Wu MJ, Ko HW, Wang D, Hung MC, Yang JY, Chang CJ. MicroRNA-205 signaling regulates mammary stem cell fate and tumorigenesis. J Clin Invest. 2014 Jul; 124(7):3093-106. PMID: 24911147; PMCID: PMC4071406.
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    306. Song S, Ajani JA, Honjo S, Maru DM, Chen Q, Scott AW, Heallen TR, Xiao L, Hofstetter WL, Weston B, Lee JH, Wadhwa R, Sudo K, Stroehlein JR, Martin JF, Hung MC, Johnson RL. Hippo coactivator YAP1 upregulates SOX9 and endows esophageal cancer cells with stem-like properties. Cancer Res. 2014 Aug 01; 74(15):4170-82. PMID: 24906622; PMCID: PMC4136429.
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    307. Zhou G, Wang J, Zhao M, Xie TX, Tanaka N, Sano D, Patel AA, Ward AM, Sandulache VC, Jasser SA, Skinner HD, Fitzgerald AL, Osman AA, Wei Y, Xia X, Songyang Z, Mills GB, Hung MC, Caulin C, Liang J, Myers JN. Gain-of-function mutant p53 promotes cell growth and cancer cell metabolism via inhibition of AMPK activation. Mol Cell. 2014 Jun 19; 54(6):960-974. PMID: 24857548; PMCID: PMC4067806.
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    308. Xie X, Kong Y, Tang H, Yang L, Hsu JL, Hung MC. Targeted BikDD expression kills androgen-dependent and castration-resistant prostate cancer cells. Mol Cancer Ther. 2014 Jul; 13(7):1813-25. PMID: 24785255; PMCID: PMC4120838.
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    309. Yan M, Zhang Y, He B, Xiang J, Wang ZF, Zheng FM, Xu J, Chen MY, Zhu YL, Wen HJ, Wan XB, Yue CF, Yang N, Zhang W, Zhang JL, Wang J, Wang Y, Li LH, Zeng YX, Lam EW, Hung MC, Liu Q. IKKa restoration via EZH2 suppression induces nasopharyngeal carcinoma differentiation. Nat Commun. 2014 Apr 17; 5:3661. PMID: 24739462.
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    310. Chou CK, Lee HH, Tsou PH, Chen CT, Hsu JM, Yamaguchi H, Wang YN, Lee HJ, Hsu JL, Lee JF, Kameoka J, Hung MC. mMAPS: a flow-proteometric technique to analyze protein-protein interactions in individual signaling complexes. Sci Signal. 2014 Mar 04; 7(315):rs1. PMID: 24595109; PMCID: PMC4120848.
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    311. Chen D, Sun Y, Yuan Y, Han Z, Zhang P, Zhang J, You MJ, Teruya-Feldstein J, Wang M, Gupta S, Hung MC, Liang H, Ma L. miR-100 induces epithelial-mesenchymal transition but suppresses tumorigenesis, migration and invasion. PLoS Genet. 2014 Feb; 10(2):e1004177. PMID: 24586203; PMCID: PMC3937226.
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    312. Zhang K, Chou CK, Xia X, Hung MC, Qin L. Block-Cell-Printing for live single-cell printing. Proc Natl Acad Sci U S A. 2014 Feb 25; 111(8):2948-53. PMID: 24516129; PMCID: PMC3939871.
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    313. Chang YW, Hung MC, Su JL. The anti-tumor activity of E1A and its implications in cancer therapy. Arch Immunol Ther Exp (Warsz). 2014 Jun; 62(3):195-204. PMID: 24504082.
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    314. Xue J, Lin X, Chiu WT, Chen YH, Yu G, Liu M, Feng XH, Sawaya R, Hung MC, Huang S, Medema RH. Sustained activation of SMAD3/SMAD4 by FOXM1 promotes TGF-?-dependent cancer metastasis. J Clin Invest. 2014 Feb; 124(2):564-79. PMID: 24382352; PMCID: PMC3904622.
      Citations: 96     Fields:    Translation:HumansAnimalsCells
    315. Chiou GY, Chien CS, Wang ML, Chen MT, Yang YP, Yu YL, Chien Y, Chang YC, Shen CC, Chio CC, Lu KH, Ma HI, Chen KH, Liu DM, Miller SA, Chen YW, Huang PI, Shih YH, Hung MC, Chiou SH. Epigenetic regulation of the miR142-3p/interleukin-6 circuit in glioblastoma. Mol Cell. 2013 Dec 12; 52(5):693-706. PMID: 24332177.
      Citations: 47     Fields:    Translation:HumansAnimalsCells
    316. Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nat Cell Biol. 2013 Dec; 15(12):1486-1494. PMID: 24270891; PMCID: PMC3951854.
      Citations: 81     Fields:    Translation:HumansAnimalsCells
    317. Wagner KW, Alam H, Dhar SS, Giri U, Li N, Wei Y, Giri D, Cascone T, Kim JH, Ye Y, Multani AS, Chan CH, Erez B, Saigal B, Chung J, Lin HK, Wu X, Hung MC, Heymach JV, Lee MG. KDM2A promotes lung tumorigenesis by epigenetically enhancing ERK1/2 signaling. J Clin Invest. 2013 Dec; 123(12):5231-46. PMID: 24200691; PMCID: PMC3859406.
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    318. Shen J, Wang Y, Hung MC. RASAL2: wrestling in the combat of Ras activation. Cancer Cell. 2013 Sep 09; 24(3):277-9. PMID: 24029223.
      Citations: 5     Fields:    Translation:HumansAnimals
    319. Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT. TIG1 promotes the development and progression of inflammatory breast cancer through activation of Axl kinase. Cancer Res. 2013 Nov 01; 73(21):6516-25. PMID: 24014597; PMCID: PMC6135947.
      Citations: 26     Fields:    Translation:HumansAnimalsCells
    320. Saldana SM, Lee HH, Lowery FJ, Khotskaya YB, Xia W, Zhang C, Chang SS, Chou CK, Steeg PS, Yu D, Hung MC. Inhibition of type I insulin-like growth factor receptor signaling attenuates the development of breast cancer brain metastasis. PLoS One. 2013; 8(9):e73406. PMID: 24039934; PMCID: PMC3764163.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    321. Khotskaya YB, Beck BH, Hurst DR, Han Z, Xia W, Hung MC, Welch DR. Expression of metastasis suppressor BRMS1 in breast cancer cells results in a marked delay in cellular adhesion to matrix. Mol Carcinog. 2014 Dec; 53(12):1011-26. PMID: 24000122; PMCID: PMC3939074.
      Citations: 9     Fields:    Translation:HumansCells
    322. Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13. PMID: 23989979; PMCID: PMC3920728.
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    323. Chan CH, Morrow JK, Li CF, Gao Y, Jin G, Moten A, Stagg LJ, Ladbury JE, Cai Z, Xu D, Logothetis CJ, Hung MC, Zhang S, Lin HK. Pharmacological inactivation of Skp2 SCF ubiquitin ligase restricts cancer stem cell traits and cancer progression. Cell. 2013 Aug 01; 154(3):556-68. PMID: 23911321; PMCID: PMC3845452.
      Citations: 199     Fields:    Translation:HumansAnimalsCells
    324. Ren J, Bollu LR, Su F, Gao G, Xu L, Huang WC, Hung MC, Weihua Z. EGFR-SGLT1 interaction does not respond to EGFR modulators, but inhibition of SGLT1 sensitizes prostate cancer cells to EGFR tyrosine kinase inhibitors. Prostate. 2013 Sep; 73(13):1453-61. PMID: 23765757.
      Citations: 23     Fields:    Translation:HumansCells
    325. Huang TH, Huo L, Wang YN, Xia W, Wei Y, Chang SS, Chang WC, Fang YF, Chen CT, Lang JY, Tu C, Wang Y, Hsu MC, Kuo HP, Ko HW, Shen J, Lee HH, Lee PC, Wu Y, Chen CH, Hung MC. Epidermal growth factor receptor potentiates MCM7-mediated DNA replication through tyrosine phosphorylation of Lyn kinase in human cancers. Cancer Cell. 2013 Jun 10; 23(6):796-810. PMID: 23764002; PMCID: PMC3703149.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    326. Chen CT, Hung MC. Beyond anti-VEGF: dual-targeting antiangiogenic and antiproliferative therapy. Am J Transl Res. 2013; 5(4):393-403. PMID: 23724163; PMCID: PMC3665913.
      Citations: 18     
    327. Huang WC, Hsu SC, Huang SJ, Chen YJ, Hsiao YC, Zhang W, Fidler IJ, Hung MC. Exogenous expression of human SGLT1 exhibits aggregations in sodium dodecyl sulfate polyacrylamide gel electrophoresis. Am J Transl Res. 2013; 5(4):441-9. PMID: 23724167; PMCID: PMC3665917.
      Citations: 5     
    328. Shen J, Xia W, Khotskaya YB, Huo L, Nakanishi K, Lim SO, Du Y, Wang Y, Chang WC, Chen CH, Hsu JL, Wu Y, Lam YC, James BP, Liu X, Liu CG, Patel DJ, Hung MC. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature. 2013 May 16; 497(7449):383-7. PMID: 23636329; PMCID: PMC3717558.
      Citations: 185     Fields:    Translation:HumansCells
    329. Yu YL, Chou RH, Liang JH, Chang WJ, Su KJ, Tseng YJ, Huang WC, Wang SC, Hung MC. Targeting the EGFR/PCNA signaling suppresses tumor growth of triple-negative breast cancer cells with cell-penetrating PCNA peptides. PLoS One. 2013; 8(4):e61362. PMID: 23593472; PMCID: PMC3620387.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    330. Yamaguchi H, Chang SS, Hsu JL, Hung MC. Signaling cross-talk in the resistance to HER family receptor targeted therapy. Oncogene. 2014 Feb 27; 33(9):1073-81. PMID: 23542173; PMCID: PMC3874419.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    331. Yu YL, Chou RH, Shyu WC, Hsieh SC, Wu CS, Chiang SY, Chang WJ, Chen JN, Tseng YJ, Lin YH, Lee W, Yeh SP, Hsu JL, Yang CC, Hung SC, Hung MC. Smurf2-mediated degradation of EZH2 enhances neuron differentiation and improves functional recovery after ischaemic stroke. EMBO Mol Med. 2013 Apr; 5(4):531-47. PMID: 23526793; PMCID: PMC3628108.
      Citations: 60     Fields:    Translation:HumansAnimalsCells
    332. Dong C, Yuan T, Wu Y, Wang Y, Fan TW, Miriyala S, Lin Y, Yao J, Shi J, Kang T, Lorkiewicz P, St Clair D, Hung MC, Evers BM, Zhou BP. Loss of FBP1 by Snail-mediated repression provides metabolic advantages in basal-like breast cancer. Cancer Cell. 2013 Mar 18; 23(3):316-31. PMID: 23453623; PMCID: PMC3703516.
      Citations: 367     Fields:    Translation:HumansAnimalsCells
    333. Du Y, Shen J, Hsu JL, Han Z, Hsu MC, Yang CC, Kuo HP, Wang YN, Yamaguchi H, Miller SA, Hung MC. Syntaxin 6-mediated Golgi translocation plays an important role in nuclear functions of EGFR through microtubule-dependent trafficking. Oncogene. 2014 Feb 06; 33(6):756-70. PMID: 23376851; PMCID: PMC3874427.
      Citations: 31     Fields:    Translation:HumansCells
    334. Yi P, Xia W, Wu RC, Lonard DM, Hung MC, O'Malley BW. SRC-3 coactivator regulates cell resistance to cytotoxic stress via TRAF4-mediated p53 destabilization. Genes Dev. 2013 Feb 01; 27(3):274-87. PMID: 23388826; PMCID: PMC3576513.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    335. Hsia TC, Tu CY, Chen YJ, Wei YL, Yu MC, Hsu SC, Tsai SL, Chen WS, Yeh MH, Yen CJ, Yu YL, Huang TC, Huang CY, Hung MC, Huang WC. Lapatinib-mediated cyclooxygenase-2 expression via epidermal growth factor receptor/HuR interaction enhances the aggressiveness of triple-negative breast cancer cells. Mol Pharmacol. 2013 Apr; 83(4):857-69. PMID: 23355539.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    336. Yamaguchi H, Hsu JL, Chen CT, Wang YN, Hsu MC, Chang SS, Du Y, Ko HW, Herbst R, Hung MC. Caspase-independent cell death is involved in the negative effect of EGF receptor inhibitors on cisplatin in non-small cell lung cancer cells. Clin Cancer Res. 2013 Feb 15; 19(4):845-54. PMID: 23344263; PMCID: PMC3703145.
      Citations: 36     Fields:    Translation:HumansCells
    337. Huang WC, Hung MC. Beyond NF-?B activation: nuclear functions of I?B kinase a. J Biomed Sci. 2013 Jan 23; 20:3. PMID: 23343355; PMCID: PMC3563485.
      Citations: 38     Fields:    Translation:HumansCells
    338. Liu CM, Hsieh CL, He YC, Lo SJ, Liang JA, Hsieh TF, Josson S, Chung LW, Hung MC, Sung SY. In vivo targeting of ADAM9 gene expression using lentivirus-delivered shRNA suppresses prostate cancer growth by regulating REG4 dependent cell cycle progression. PLoS One. 2013; 8(1):e53795. PMID: 23342005; PMCID: PMC3547060.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    339. Lin SP, Lee YT, Wang JY, Miller SA, Chiou SH, Hung MC, Hung SC. Survival of cancer stem cells under hypoxia and serum depletion via decrease in PP2A activity and activation of p38-MAPKAPK2-Hsp27. PLoS One. 2012; 7(11):e49605. PMID: 23185379; PMCID: PMC3502468.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    340. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KKC, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 Ligase Regulates Akt Ubiquitination, Glycolysis, Herceptin Sensitivity, and Tumorigenesis. Cell. 2012 11 09; 151(4):913-914. PMID: 30360292.
      Citations: 15     Fields:    
    341. Chen PS, Su JL, Hung MC. Dysregulation of microRNAs in cancer. J Biomed Sci. 2012 Oct 17; 19:90. PMID: 23075324; PMCID: PMC3482395.
      Citations: 57     Fields:    Translation:Humans
    342. Chen YH, Hung MC, Li LY. EZH2: a pivotal regulator in controlling cell differentiation. Am J Transl Res. 2012; 4(4):364-75. PMID: 23145205; PMCID: PMC3493026.
      Citations: 26     
    343. Li L, Xie X, Luo J, Liu M, Xi S, Guo J, Kong Y, Wu M, Gao J, Xie Z, Tang J, Wang X, Wei W, Yang M, Hung MC, Xie X. Targeted expression of miR-34a using the T-VISA system suppresses breast cancer cell growth and invasion. Mol Ther. 2012 Dec; 20(12):2326-34. PMID: 23032974; PMCID: PMC3519992.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    344. Lin SP, Lee YT, Yang SH, Miller SA, Chiou SH, Hung MC, Hung SC. Colon cancer stem cells resist antiangiogenesis therapy-induced apoptosis. Cancer Lett. 2013 Jan 28; 328(2):226-34. PMID: 23017941.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    345. Chen D, Sun Y, Wei Y, Zhang P, Rezaeian AH, Teruya-Feldstein J, Gupta S, Liang H, Lin HK, Hung MC, Ma L. LIFR is a breast cancer metastasis suppressor upstream of the Hippo-YAP pathway and a prognostic marker. Nat Med. 2012 Oct; 18(10):1511-7. PMID: 23001183; PMCID: PMC3684419.
      Citations: 208     Fields:    Translation:HumansAnimalsCells
    346. Lee DF, Su J, Ang YS, Carvajal-Vergara X, Mulero-Navarro S, Pereira CF, Gingold J, Wang HL, Zhao R, Sevilla A, Darr H, Williamson AJ, Chang B, Niu X, Aguilo F, Flores ER, Sher YP, Hung MC, Whetton AD, Gelb BD, Moore KA, Snoeck HW, Ma'ayan A, Schaniel C, Lemischka IR. Regulation of embryonic and induced pluripotency by aurora kinase-p53 signaling. Cell Stem Cell. 2012 Aug 03; 11(2):179-94. PMID: 22862944; PMCID: PMC3413175.
      Citations: 84     Fields:    Translation:HumansAnimalsCells
    347. Hung MC. On mammary gland growth factors: roles in normal development and in cancer. Cold Spring Harb Perspect Biol. 2012 Aug 01; 4(8):a013532. PMID: 22855727; PMCID: PMC3405857.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    348. Chen CT, Du Y, Yamaguchi H, Hsu JM, Kuo HP, Hortobagyi GN, Hung MC. Targeting the IKK?/mTOR/VEGF signaling pathway as a potential therapeutic strategy for obesity-related breast cancer. Mol Cancer Ther. 2012 Oct; 11(10):2212-21. PMID: 22826466; PMCID: PMC3712288.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    349. Yu YL, Chou RH, Wu CH, Wang YN, Chang WJ, Tseng YJ, Chang WC, Lai CC, Lee HJ, Huo L, Chen CH, Hung MC. Nuclear EGFR suppresses ribonuclease activity of polynucleotide phosphorylase through DNAPK-mediated phosphorylation at serine 776. J Biol Chem. 2012 Sep 07; 287(37):31015-26. PMID: 22815474; PMCID: PMC3438934.
      Citations: 28     Fields:    Translation:HumansCells
    350. Xie X, Li L, Xiao X, Guo J, Kong Y, Wu M, Liu W, Gao G, Hsu JL, Wei W, Hung MC, Xie X. Targeted expression of BikDD eliminates breast cancer with virtually no toxicity in noninvasive imaging models. Mol Cancer Ther. 2012 Sep; 11(9):1915-24. PMID: 22752427.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    351. Hong S, Tsou PH, Chou CK, Yamaguchi H, Su CB, Hung MC, Kameoka J. Microfluidic three-dimensional hydrodynamic flow focusing for the rapid protein concentration analysis. Biomicrofluidics. 2012 Jun; 6(2):24132. PMID: 23785388; PMCID: PMC3391308.
      Citations: 2     
    352. Chan CH, Li CF, Yang WL, Gao Y, Lee SW, Feng Z, Huang HY, Tsai KK, Flores LG, Shao Y, Hazle JD, Yu D, Wei W, Sarbassov D, Hung MC, Nakayama KI, Lin HK. The Skp2-SCF E3 ligase regulates Akt ubiquitination, glycolysis, herceptin sensitivity, and tumorigenesis. Cell. 2012 May 25; 149(5):1098-111. PMID: 22632973; PMCID: PMC3586339.
      Citations: 184     Fields:    Translation:HumansAnimalsCells
    353. Yang PW, Hung MC, Hsieh CY, Tung EC, Wang YH, Tsai JC, Lee JM. The effects of Photofrin-mediated photodynamic therapy on the modulation of EGFR in esophageal squamous cell carcinoma cells. Lasers Med Sci. 2013 Feb; 28(2):605-14. PMID: 22585382.
      Citations: 11     Fields:    Translation:HumansCells
    354. De Wever O, Hendrix A, Lambein K, Land D, Bracke M, Hung MC, Larsen AK, Emami S, Gespach C, Ouelaa-Benslama R, Sabbah M, Pr?vost G. Identification of a GaG??, AKT and PKCa signalome associated with invasive growth in two genetic models of human breast cancer cell epithelial-to-mesenchymal transition. Int J Oncol. 2012 Jul; 41(1):189-200. PMID: 22552300.
      Citations: 10     Fields:    Translation:HumansCells
    355. Wang YN, Hung MC. Nuclear functions and subcellular trafficking mechanisms of the epidermal growth factor receptor family. Cell Biosci. 2012 Apr 20; 2(1):13. PMID: 22520625; PMCID: PMC3418567.
      Citations: 68     
    356. Nie L, Wu HJ, Hsu JM, Chang SS, Labaff AM, Li CW, Wang Y, Hsu JL, Hung MC. Long non-coding RNAs: versatile master regulators of gene expression and crucial players in cancer. Am J Transl Res. 2012; 4(2):127-50. PMID: 22611467; PMCID: PMC3353529.
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    357. Huang WC, Chen WS, Chen YJ, Wang LY, Hsu SC, Chen CC, Hung MC. Hepatitis B virus X protein induces IKKa nuclear translocation via Akt-dependent phosphorylation to promote the motility of hepatocarcinoma cells. J Cell Physiol. 2012 Apr; 227(4):1446-54. PMID: 21618535.
      Citations: 18     Fields:    Translation:HumansCells
    358. Wang YN, Lee HH, Lee HJ, Du Y, Yamaguchi H, Hung MC. Membrane-bound trafficking regulates nuclear transport of integral epidermal growth factor receptor (EGFR) and ErbB-2. J Biol Chem. 2012 May 11; 287(20):16869-79. PMID: 22451678; PMCID: PMC3351284.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    359. Wang Y, Ding Q, Yen CJ, Xia W, Izzo JG, Lang JY, Li CW, Hsu JL, Miller SA, Wang X, Lee DF, Hsu JM, Huo L, Labaff AM, Liu D, Huang TH, Lai CC, Tsai FJ, Chang WC, Chen CH, Wu TT, Buttar NS, Wang KK, Wu Y, Wang H, Ajani J, Hung MC. The crosstalk of mTOR/S6K1 and Hedgehog pathways. Cancer Cell. 2012 Mar 20; 21(3):374-87. PMID: 22439934; PMCID: PMC3350095.
      Citations: 197     Fields:    Translation:HumansAnimalsCells
    360. Yang WH, Lan HY, Huang CH, Tai SK, Tzeng CH, Kao SY, Wu KJ, Hung MC, Yang MH. RAC1 activation mediates Twist1-induced cancer cell migration. Nat Cell Biol. 2012 Mar 11; 14(4):366-74. PMID: 22407364.
      Citations: 115     Fields:    Translation:HumansCells
    361. Yamaguchi H, Hsu JL, Hung MC. Regulation of ubiquitination-mediated protein degradation by survival kinases in cancer. Front Oncol. 2012; 2:15. PMID: 22649777; PMCID: PMC3355968.
      Citations: 28     
    362. Li CW, Xia W, Huo L, Lim SO, Wu Y, Hsu JL, Chao CH, Yamaguchi H, Yang NK, Ding Q, Wang Y, Lai YJ, LaBaff AM, Wu TJ, Lin BR, Yang MH, Hortobagyi GN, Hung MC. Epithelial-mesenchymal transition induced by TNF-a requires NF-?B-mediated transcriptional upregulation of Twist1. Cancer Res. 2012 Mar 01; 72(5):1290-300. PMID: 22253230; PMCID: PMC3350107.
      Citations: 223     Fields:    Translation:HumansAnimalsCells
    363. Ling J, Kang Y, Zhao R, Xia Q, Lee DF, Chang Z, Li J, Peng B, Fleming JB, Wang H, Liu J, Lemischka IR, Hung MC, Chiao PJ. KrasG12D-induced IKK2/?/NF-?B activation by IL-1a and p62 feedforward loops is required for development of pancreatic ductal adenocarcinoma. Cancer Cell. 2012 Jan 17; 21(1):105-20. PMID: 22264792; PMCID: PMC3360958.
      Citations: 261     Fields:    Translation:HumansAnimalsCells
    364. Li X, Lu Y, Liang K, Hsu JM, Albarracin C, Mills GB, Hung MC, Fan Z. Brk/PTK6 sustains activated EGFR signaling through inhibiting EGFR degradation and transactivating EGFR. Oncogene. 2012 Oct 04; 31(40):4372-83. PMID: 22231447; PMCID: PMC3326223.
      Citations: 30     Fields:    Translation:HumansCells
    365. Zhao H, Ho PC, Lo YH, Espejo A, Bedford MT, Hung MC, Wang SC. Interaction of proliferation cell nuclear antigen (PCNA) with c-Abl in cell proliferation and response to DNA damages in breast cancer. PLoS One. 2012; 7(1):e29416. PMID: 22238610; PMCID: PMC3251568.
      Citations: 22     Fields:    Translation:HumansCells
    366. Liu M, Lee DF, Chen CT, Yen CJ, Li LY, Lee HJ, Chang CJ, Chang WC, Hsu JM, Kuo HP, Xia W, Wei Y, Chiu PC, Chou CK, Du Y, Dhar D, Karin M, Chen CH, Hung MC. IKKa activation of NOTCH links tumorigenesis via FOXA2 suppression. Mol Cell. 2012 Jan 27; 45(2):171-84. PMID: 22196886; PMCID: PMC3268914.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    367. Chang CJ, Hung MC. The role of EZH2 in tumour progression. Br J Cancer. 2012 Jan 17; 106(2):243-7. PMID: 22187039; PMCID: PMC3261672.
      Citations: 157     Fields:    Translation:HumansCells
    368. Hung MC, Link W. Protein localization in disease and therapy. J Cell Sci. 2011 Oct 15; 124(Pt 20):3381-92. PMID: 22010196.
      Citations: 131     Fields:    Translation:HumansAnimalsCells
    369. Ding Q, Chang CJ, Xie X, Xia W, Yang JY, Wang SC, Wang Y, Xia J, Chen L, Cai C, Li H, Yen CJ, Kuo HP, Lee DF, Lang J, Huo L, Cheng X, Chen YJ, Li CW, Jeng LB, Hsu JL, Li LY, Tan A, Curley SA, Ellis LM, Dubois RN, Hung MC. APOBEC3G promotes liver metastasis in an orthotopic mouse model of colorectal cancer and predicts human hepatic metastasis. J Clin Invest. 2011 Nov; 121(11):4526-36. PMID: 21985787; PMCID: PMC3204827.
      Citations: 65     Fields:    Translation:HumansAnimalsCells
    370. Lang JY, Hsu JL, Meric-Bernstam F, Chang CJ, Wang Q, Bao Y, Yamaguchi H, Xie X, Woodward WA, Yu D, Hortobagyi GN, Hung MC. BikDD eliminates breast cancer initiating cells and synergizes with lapatinib for breast cancer treatment. Cancer Cell. 2011 Sep 13; 20(3):341-56. PMID: 21907925; PMCID: PMC3172580.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    371. Su JL, Cheng X, Yamaguchi H, Chang YW, Hou CF, Lee DF, Ko HW, Hua KT, Wang YN, Hsiao M, Chen PB, Hsu JM, Bast RC, Hortobagyi GN, Hung MC. FOXO3a-Dependent Mechanism of E1A-Induced Chemosensitization. Cancer Res. 2011 Nov 01; 71(21):6878-87. PMID: 21911455; PMCID: PMC3242367.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    372. Lee JC, Chou LC, Huang CH, Chung JG, Huang LJ, Lee KH, Hung MC, Way TD, Kuo SC. CHM-1 induces apoptosis via p38-mediated upregulation of DR5 expression in human ovarian cancer SKOV3 cells. Eur J Pharmacol. 2011 Nov 16; 670(1):96-104. PMID: 21907193.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    373. Le XF, Mao W, He G, Claret FX, Xia W, Ahmed AA, Hung MC, Siddik ZH, Bast RC. The role of p27(Kip1) in dasatinib-enhanced paclitaxel cytotoxicity in human ovarian cancer cells. J Natl Cancer Inst. 2011 Sep 21; 103(18):1403-22. PMID: 21813412; PMCID: PMC3176777.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    374. Yang JY, Hung MC. Deciphering the role of forkhead transcription factors in cancer therapy. Curr Drug Targets. 2011 Aug; 12(9):1284-90. PMID: 21443462; PMCID: PMC3149891.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    375. Jan CI, Yu CC, Hung MC, Harn HJ, Nieh S, Lee HS, Lou MA, Wu YC, Chen CY, Huang CY, Chen FN, Lo JF. Tid1, CHIP and ErbB2 interactions and their prognostic implications for breast cancer patients. J Pathol. 2011 Nov; 225(3):424-37. PMID: 21710689.
      Citations: 24     Fields:    Translation:Humans
    376. Chen YJ, Huang WC, Wei YL, Hsu SC, Yuan P, Lin HY, Wistuba II, Lee JJ, Yen CJ, Su WC, Chang KY, Chang WC, Chou TC, Chou CK, Tsai CH, Hung MC. Elevated BCRP/ABCG2 expression confers acquired resistance to gefitinib in wild-type EGFR-expressing cells. PLoS One. 2011; 6(6):e21428. PMID: 21731744; PMCID: PMC3121773.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    377. Banerjee A, Lang JY, Hung MC, Sengupta K, Banerjee SK, Baksi K, Banerjee DK. Unfolded protein response is required in nu/nu mice microvasculature for treating breast tumor with tunicamycin. J Biol Chem. 2011 Aug 19; 286(33):29127-29138. PMID: 21676868; PMCID: PMC3190720.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    378. Tsai KS, Yang SH, Lei YP, Tsai CC, Chen HW, Hsu CY, Chen LL, Wang HW, Miller SA, Chiou SH, Hung MC, Hung SC. Mesenchymal stem cells promote formation of colorectal tumors in mice. Gastroenterology. 2011 Sep; 141(3):1046-56. PMID: 21699785.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    379. Chen CT, Yamaguchi H, Lee HJ, Du Y, Lee HH, Xia W, Yu WH, Hsu JL, Yen CJ, Sun HL, Wang Y, Yeh ET, Hortobagyi GN, Hung MC. Dual targeting of tumor angiogenesis and chemotherapy by endostatin-cytosine deaminase-uracil phosphoribosyltransferase. Mol Cancer Ther. 2011 Aug; 10(8):1327-36. PMID: 21610170; PMCID: PMC3155219.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    380. Li LY, Chen H, Hsieh YH, Wang YN, Chu HJ, Chen YH, Chen HY, Chien PJ, Ma HT, Tsai HC, Lai CC, Sher YP, Lien HC, Tsai CH, Hung MC. Nuclear ErbB2 enhances translation and cell growth by activating transcription of ribosomal RNA genes. Cancer Res. 2011 Jun 15; 71(12):4269-79. PMID: 21555369; PMCID: PMC3117049.
      Citations: 38     Fields:    Translation:HumansCells
    381. Chou RH, Yu YL, Hung MC. The roles of EZH2 in cell lineage commitment. Am J Transl Res. 2011 May 15; 3(3):243-50. PMID: 21654879; PMCID: PMC3102568.
      Citations: 46     
    382. Huang WC, Chen YJ, Li LY, Wei YL, Hsu SC, Tsai SL, Chiu PC, Huang WP, Wang YN, Chen CH, Chang WC, Chang WC, Chen AJ, Tsai CH, Hung MC. Nuclear translocation of epidermal growth factor receptor by Akt-dependent phosphorylation enhances breast cancer-resistant protein expression in gefitinib-resistant cells. J Biol Chem. 2011 Jun 10; 286(23):20558-68. PMID: 21487020; PMCID: PMC3121497.
      Citations: 88     Fields:    Translation:HumansCells
    383. Jiang T, Grabiner B, Zhu Y, Jiang C, Li H, You Y, Lang J, Hung MC, Lin X. CARMA3 is crucial for EGFR-Induced activation of NF-?B and tumor progression. Cancer Res. 2011 Mar 15; 71(6):2183-92. PMID: 21406399; PMCID: PMC3059846.
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    384. Kim SJ, Kim JS, Park ES, Lee JS, Lin Q, Langley RR, Maya M, He J, Kim SW, Weihua Z, Balasubramanian K, Fan D, Mills GB, Hung MC, Fidler IJ. Astrocytes upregulate survival genes in tumor cells and induce protection from chemotherapy. Neoplasia. 2011 Mar; 13(3):286-98. PMID: 21390191; PMCID: PMC3050871.
      Citations: 126     Fields:    Translation:HumansAnimalsCells
    385. Chang CJ, Chao CH, Xia W, Yang JY, Xiong Y, Li CW, Yu WH, Rehman SK, Hsu JL, Lee HH, Liu M, Chen CT, Yu D, Hung MC. p53 regulates epithelial-mesenchymal transition and stem cell properties through modulating miRNAs. Nat Cell Biol. 2011 Mar; 13(3):317-23. PMID: 21336307; PMCID: PMC3075845.
      Citations: 368     Fields:    Translation:HumansCells
    386. Sher YP, Liu SJ, Chang CM, Lien SP, Chen CH, Han Z, Li LY, Chen JS, Wu CW, Hung MC. Cancer-targeted BikDD gene therapy elicits protective antitumor immunity against lung cancer. Mol Cancer Ther. 2011 Apr; 10(4):637-47. PMID: 21282355.
      Citations: 8     Fields:    Translation:AnimalsCells
    387. Hsu JM, Chen CT, Chou CK, Kuo HP, Li LY, Lin CY, Lee HJ, Wang YN, Liu M, Liao HW, Shi B, Lai CC, Bedford MT, Tsai CH, Hung MC. Crosstalk between Arg?1175 methylation and Tyr?1173 phosphorylation negatively modulates EGFR-mediated ERK activation. Nat Cell Biol. 2011 Feb; 13(2):174-81. PMID: 21258366; PMCID: PMC3048027.
      Citations: 104     Fields:    Translation:HumansCells
    388. Chen YH, Yeh FL, Yeh SP, Ma HT, Hung SC, Hung MC, Li LY. Myocyte enhancer factor-2 interacting transcriptional repressor (MITR) is a switch that promotes osteogenesis and inhibits adipogenesis of mesenchymal stem cells by inactivating peroxisome proliferator-activated receptor gamma-2. J Biol Chem. 2011 Mar 25; 286(12):10671-80. PMID: 21247904; PMCID: PMC3060518.
      Citations: 29     Fields:    Translation:HumansCells
    389. Yu YL, Chou RH, Chen LT, Shyu WC, Hsieh SC, Wu CS, Zeng HJ, Yeh SP, Yang DM, Hung SC, Hung MC. EZH2 regulates neuronal differentiation of mesenchymal stem cells through PIP5K1C-dependent calcium signaling. J Biol Chem. 2011 Mar 18; 286(11):9657-67. PMID: 21216957; PMCID: PMC3059014.
      Citations: 29     Fields:    Translation:HumansCells
    390. Chang CJ, Yang JY, Xia W, Chen CT, Xie X, Chao CH, Woodward WA, Hsu JM, Hortobagyi GN, Hung MC. EZH2 promotes expansion of breast tumor initiating cells through activation of RAF1-?-catenin signaling. Cancer Cell. 2011 Jan 18; 19(1):86-100. PMID: 21215703; PMCID: PMC3041516.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    391. Zhao H, Lo YH, Ma L, Waltz SE, Gray JK, Hung MC, Wang SC. Targeting tyrosine phosphorylation of PCNA inhibits prostate cancer growth. Mol Cancer Ther. 2011 Jan; 10(1):29-36. PMID: 21220489; PMCID: PMC3066081.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    392. Tsai WW, Wang Z, Yiu TT, Akdemir KC, Xia W, Winter S, Tsai CY, Shi X, Schwarzer D, Plunkett W, Aronow B, Gozani O, Fischle W, Hung MC, Patel DJ, Barton MC. TRIM24 links a non-canonical histone signature to breast cancer. Nature. 2010 Dec 16; 468(7326):927-32. PMID: 21164480; PMCID: PMC3058826.
      Citations: 205     Fields:    Translation:HumansCells
    393. Wei Y, Chen YH, Li LY, Lang J, Yeh SP, Shi B, Yang CC, Yang JY, Lin CY, Lai CC, Hung MC. CDK1-dependent phosphorylation of EZH2 suppresses methylation of H3K27 and promotes osteogenic differentiation of human mesenchymal stem cells. Nat Cell Biol. 2011 Jan; 13(1):87-94. PMID: 21131960; PMCID: PMC3076036.
      Citations: 195     Fields:    Translation:HumansCells
    394. Rhodes LV, Short SP, Neel NF, Salvo VA, Zhu Y, Elliott S, Wei Y, Yu D, Sun M, Muir SE, Fonseca JP, Bratton MR, Segar C, Tilghman SL, Sobolik-Delmaire T, Horton LW, Zaja-Milatovic S, Collins-Burow BM, Wadsworth S, Beckman BS, Wood CE, Fuqua SA, Nephew KP, Dent P, Worthylake RA, Curiel TJ, Hung MC, Richmond A, Burow ME. Cytokine receptor CXCR4 mediates estrogen-independent tumorigenesis, metastasis, and resistance to endocrine therapy in human breast cancer. Cancer Res. 2011 Jan 15; 71(2):603-13. PMID: 21123450; PMCID: PMC3140407.
      Citations: 89     Fields:    Translation:HumansAnimalsCells
    395. Song H, Li CW, Labaff AM, Lim SO, Li LY, Kan SF, Chen Y, Zhang K, Lang J, Xie X, Wang Y, Huo LF, Hsu SC, Chen X, Zhao Y, Hung MC. Acetylation of EGF receptor contributes to tumor cell resistance to histone deacetylase inhibitors. Biochem Biophys Res Commun. 2011 Jan 07; 404(1):68-73. PMID: 21094134; PMCID: PMC3049249.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    396. Jin Q, Yuan LX, Boulbes D, Baek JM, Wang YN, Gomez-Cabello D, Hawke DH, Yeung SC, Lee MH, Hortobagyi GN, Hung MC, Esteva FJ. Fatty acid synthase phosphorylation: a novel therapeutic target in HER2-overexpressing breast cancer cells. Breast Cancer Res. 2010; 12(6):R96. PMID: 21080941; PMCID: PMC3046439.
      Citations: 47     Fields:    Translation:HumansCells
    397. Liang K, Esteva FJ, Albarracin C, Stemke-Hale K, Lu Y, Bianchini G, Yang CY, Li Y, Li X, Chen CT, Mills GB, Hortobagyi GN, Mendelsohn J, Hung MC, Fan Z. Recombinant human erythropoietin antagonizes trastuzumab treatment of breast cancer cells via Jak2-mediated Src activation and PTEN inactivation. Cancer Cell. 2010 Nov 16; 18(5):423-35. PMID: 21075308; PMCID: PMC3022383.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    398. Beyer I, Li Z, Persson J, Liu Y, van Rensburg R, Yumul R, Zhang XB, Hung MC, Lieber A. Controlled extracellular matrix degradation in breast cancer tumors improves therapy by trastuzumab. Mol Ther. 2011 Mar; 19(3):479-89. PMID: 21081901; PMCID: PMC3048180.
      Citations: 32     Fields:    Translation:HumansAnimalsCells
    399. Cheng X, Xia W, Yang JY, Hsu JL, Chou CK, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of p21(CIP1/WAF1) in mammary epithelium accelerates mammary tumorigenesis and promotes lung metastasis. Biochem Biophys Res Commun. 2010 Dec 03; 403(1):103-7. PMID: 21040707; PMCID: PMC3001223.
      Citations: 14     Fields:    Translation:HumansAnimals
    400. Wang YN, Yamaguchi H, Huo L, Du Y, Lee HJ, Lee HH, Wang H, Hsu JM, Hung MC. The translocon Sec61beta localized in the inner nuclear membrane transports membrane-embedded EGF receptor to the nucleus. J Biol Chem. 2010 Dec 03; 285(49):38720-9. PMID: 20937808; PMCID: PMC2992305.
      Citations: 65     Fields:    Translation:HumansCells
    401. Hong S, Wang YN, Yamaguchi H, Sreenivasappa H, Chou CK, Tsou PH, Hung MC, Kameoka J. MEASUREMENT of Protein 53 Diffusion Coefficient in Live HeLa Cells Using Raster Image Correlation Spectroscopy (RICS). J Biomater Nanobiotechnol. 2010 Oct; 1(1):31-36. PMID: 21804949; PMCID: PMC3146256.
      Citations: 4     
    402. Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. Rapid detection of two-protein interaction with a single fluorophore by using a microfluidic device. Analyst. 2010 Nov; 135(11):2907-12. PMID: 20877860; PMCID: PMC3001224.
      Citations: 1     Fields:    Translation:HumansCells
    403. Luyimbazi D, Akcakanat A, McAuliffe PF, Zhang L, Singh G, Gonzalez-Angulo AM, Chen H, Do KA, Zheng Y, Hung MC, Mills GB, Meric-Bernstam F. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol Cancer Ther. 2010 Oct; 9(10):2770-84. PMID: 20876744; PMCID: PMC2965451.
      Citations: 33     Fields:    Translation:HumansCells
    404. Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natschke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K, Hung MC, Lee EY, Lee KH. Antitumor Agents. 282. 2'-(R)-O-acetylglaucarubinone, a quassinoid from Odyendyea gabonensis as a potential anti-breast and anti-ovarian cancer agent. J Nat Prod. 2010 Sep 24; 73(9):1553-8. PMID: 20738103; PMCID: PMC2954497.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    405. Zhu QS, Rosenblatt K, Huang KL, Lahat G, Brobey R, Bolshakov S, Nguyen T, Ding Z, Belousov R, Bill K, Luo X, Lazar A, Dicker A, Mills GB, Hung MC, Lev D. Vimentin is a novel AKT1 target mediating motility and invasion. Oncogene. 2011 Jan 27; 30(4):457-70. PMID: 20856200; PMCID: PMC3010301.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    406. Cheng X, Xia W, Yang JY, Hsu JL, Lang JY, Chou CK, Du Y, Sun HL, Wyszomierski SL, Mills GB, Muller WJ, Yu D, Hung MC. Activation of murine double minute 2 by Akt in mammary epithelium delays mammary involution and accelerates mammary tumorigenesis. Cancer Res. 2010 Oct 01; 70(19):7684-9. PMID: 20841468; PMCID: PMC2948588.
      Citations: 9     Fields:    Translation:AnimalsCells
    407. Huo L, Wang YN, Xia W, Hsu SC, Lai CC, Li LY, Chang WC, Wang Y, Hsu MC, Yu YL, Huang TH, Ding Q, Chen CH, Tsai CH, Hung MC. RNA helicase A is a DNA-binding partner for EGFR-mediated transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2010 Sep 14; 107(37):16125-30. PMID: 20802156; PMCID: PMC2941329.
      Citations: 53     Fields:    Translation:HumansCells
    408. Lu C, Han HD, Mangala LS, Ali-Fehmi R, Newton CS, Ozbun L, Armaiz-Pena GN, Hu W, Stone RL, Munkarah A, Ravoori MK, Shahzad MM, Lee JW, Mora E, Langley RR, Carroll AR, Matsuo K, Spannuth WA, Schmandt R, Jennings NB, Goodman BW, Jaffe RB, Nick AM, Kim HS, Guven EO, Chen YH, Li LY, Hsu MC, Coleman RL, Calin GA, Denkbas EB, Lim JY, Lee JS, Kundra V, Birrer MJ, Hung MC, Lopez-Berestein G, Sood AK. Regulation of tumor angiogenesis by EZH2. Cancer Cell. 2010 Aug 09; 18(2):185-97. PMID: 20708159; PMCID: PMC2923653.
      Citations: 201     Fields:    Translation:AnimalsCells
    409. Yamaguchi H, Chen CT, Chou CK, Pal A, Bornmann W, Hortobagyi GN, Hung MC. Adenovirus 5 E1A enhances histone deacetylase inhibitors-induced apoptosis through Egr-1-mediated Bim upregulation. Oncogene. 2010 Oct 14; 29(41):5619-29. PMID: 20676141; PMCID: PMC2955174.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    410. Wang YN, Wang H, Yamaguchi H, Lee HJ, Lee HH, Hung MC. COPI-mediated retrograde trafficking from the Golgi to the ER regulates EGFR nuclear transport. Biochem Biophys Res Commun. 2010 Sep 03; 399(4):498-504. PMID: 20674546; PMCID: PMC2935258.
      Citations: 64     Fields:    Translation:HumansCells
    411. Su JL, Chen PB, Chen YH, Chen SC, Chang YW, Jan YH, Cheng X, Hsiao M, Hung MC. Downregulation of microRNA miR-520h by E1A contributes to anticancer activity. Cancer Res. 2010 Jun 15; 70(12):5096-108. PMID: 20501832; PMCID: PMC2891368.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    412. Chou CK, Jing N, Yamaguchi H, Tsou PH, Lee HH, Chen CT, Wang YN, Hong S, Su C, Kameoka J, Hung MC. High speed digital protein interaction analysis using microfluidic single molecule detection system. Lab Chip. 2010 Jul 21; 10(14):1793-8. PMID: 20498894; PMCID: PMC2919816.
      Citations: 4     Fields:    
    413. Subik K, Lee JF, Baxter L, Strzepek T, Costello D, Crowley P, Xing L, Hung MC, Bonfiglio T, Hicks DG, Tang P. The Expression Patterns of ER, PR, HER2, CK5/6, EGFR, Ki-67 and AR by Immunohistochemical Analysis in Breast Cancer Cell Lines. Breast Cancer (Auckl). 2010 May 20; 4:35-41. PMID: 20697531; PMCID: PMC2914277.
      Citations: 312     
    414. Yang JY, Chang CJ, Xia W, Wang Y, Wong KK, Engelman JA, Du Y, Andreeff M, Hortobagyi GN, Hung MC. Activation of FOXO3a is sufficient to reverse mitogen-activated protein/extracellular signal-regulated kinase kinase inhibitor chemoresistance in human cancer. Cancer Res. 2010 Jun 01; 70(11):4709-18. PMID: 20484037; PMCID: PMC2895805.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    415. Wang YN, Yamaguchi H, Hsu JM, Hung MC. Nuclear trafficking of the epidermal growth factor receptor family membrane proteins. Oncogene. 2010 Jul 15; 29(28):3997-4006. PMID: 20473332; PMCID: PMC2904849.
      Citations: 98     Fields:    Translation:HumansAnimalsCells
    416. Yang G, Chang B, Yang F, Guo X, Cai KQ, Xiao XS, Wang H, Sen S, Hung MC, Mills GB, Chang S, Multani AS, Mercado-Uribe I, Liu J. Aurora kinase A promotes ovarian tumorigenesis through dysregulation of the cell cycle and suppression of BRCA2. Clin Cancer Res. 2010 Jun 15; 16(12):3171-81. PMID: 20423983; PMCID: PMC2930838.
      Citations: 63     Fields:    Translation:HumansCells
    417. Lahat G, Zhu QS, Huang KL, Wang S, Bolshakov S, Liu J, Torres K, Langley RR, Lazar AJ, Hung MC, Lev D. Vimentin is a novel anti-cancer therapeutic target; insights from in vitro and in vivo mice xenograft studies. PLoS One. 2010 Apr 16; 5(4):e10105. PMID: 20419128; PMCID: PMC2855704.
      Citations: 99     Fields:    Translation:AnimalsCells
    418. Chan CH, Lee SW, Li CF, Wang J, Yang WL, Wu CY, Wu J, Nakayama KI, Kang HY, Huang HY, Hung MC, Pandolfi PP, Lin HK. Deciphering the transcriptional complex critical for RhoA gene expression and cancer metastasis. Nat Cell Biol. 2010 May; 12(5):457-67. PMID: 20383141; PMCID: PMC3855841.
      Citations: 123     Fields:    Translation:HumansAnimalsCells
    419. Bredfeldt TG, Greathouse KL, Safe SH, Hung MC, Bedford MT, Walker CL. Xenoestrogen-induced regulation of EZH2 and histone methylation via estrogen receptor signaling to PI3K/AKT. Mol Endocrinol. 2010 May; 24(5):993-1006. PMID: 20351197; PMCID: PMC2870935.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    420. Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, Hung MC, Lee EY, Lee KH. Antitumor agents. 272. Structure-activity relationships and in vivo selective anti-breast cancer activity of novel neo-tanshinlactone analogues. J Med Chem. 2010 Mar 11; 53(5):2299-308. PMID: 20148565; PMCID: PMC2849726.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    421. Zhang W, Konopleva M, Burks JK, Dywer KC, Schober WD, Yang JY, McQueen TJ, Hung MC, Andreeff M. Blockade of mitogen-activated protein kinase/extracellular signal-regulated kinase kinase and murine double minute synergistically induces Apoptosis in acute myeloid leukemia via BH3-only proteins Puma and Bim. Cancer Res. 2010 Mar 15; 70(6):2424-34. PMID: 20215498; PMCID: PMC2840060.
      Citations: 40     Fields:    Translation:HumansCells
    422. Kuo HP, Lee DF, Chen CT, Liu M, Chou CK, Lee HJ, Du Y, Xie X, Wei Y, Xia W, Weihua Z, Yang JY, Yen CJ, Huang TH, Tan M, Xing G, Zhao Y, Lin CH, Tsai SF, Fidler IJ, Hung MC. ARD1 stabilization of TSC2 suppresses tumorigenesis through the mTOR signaling pathway. Sci Signal. 2010 Feb 09; 3(108):ra9. PMID: 20145209; PMCID: PMC2874891.
      Citations: 41     Fields:    Translation:HumansAnimalsCells
    423. Liao Y, Hung MC. Physiological regulation of Akt activity and stability. Am J Transl Res. 2010 Jan 01; 2(1):19-42. PMID: 20182580; PMCID: PMC2826820.
      Citations: 178     
    424. Kuo HP, Hung MC. Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? Am J Transl Res. 2010 Jan 01; 2(1):56-64. PMID: 20182582; PMCID: PMC2826822.
      Citations: 13     
    425. Esteva FJ, Yu D, Hung MC, Hortobagyi GN. Molecular predictors of response to trastuzumab and lapatinib in breast cancer. Nat Rev Clin Oncol. 2010 Feb; 7(2):98-107. PMID: 20027191.
      Citations: 69     Fields:    Translation:Humans
    426. Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH. Antitumor agents 270. Novel substituted 6-phenyl-4H-furo[3,2-c]pyran-4-one derivatives as potent and highly selective anti-breast cancer agents. Bioorg Med Chem. 2010 Jan 15; 18(2):803-8. PMID: 20034799; PMCID: PMC2821697.
      Citations: 5     Fields:    Translation:HumansCells
    427. Andre F, Xia W, Conforti R, Wei Y, Boulet T, Tomasic G, Spielmann M, Zoubir M, Berrada N, Arriagada R, Hortobagyi GN, Hung MC, Pusztai L, Delaloge S, Michiels S, Cristofanilli M. CXCR4 expression in early breast cancer and risk of distant recurrence. Oncologist. 2009 Dec; 14(12):1182-8. PMID: 19939894.
      Citations: 31     Fields:    Translation:Humans
    428. Chou CK, Lee DF, Sun HL, Li LY, Lin CY, Huang WC, Hsu JM, Kuo HP, Yamaguchi H, Wang YN, Liu M, Wu HY, Liao PC, Yen CJ, Hung MC. The suppression of MAD1 by AKT-mediated phosphorylation activates MAD1 target genes transcription. Mol Carcinog. 2009 Nov; 48(11):1048-58. PMID: 19526459; PMCID: PMC2783450.
      Citations: 13     Fields:    Translation:HumansCells
    429. Wang SC, Hung MC. Nuclear translocation of the epidermal growth factor receptor family membrane tyrosine kinase receptors. Clin Cancer Res. 2009 Nov 01; 15(21):6484-9. PMID: 19861462; PMCID: PMC5537741.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    430. Zhang D, LaFortune TA, Krishnamurthy S, Esteva FJ, Cristofanilli M, Liu P, Lucci A, Singh B, Hung MC, Hortobagyi GN, Ueno NT. Epidermal growth factor receptor tyrosine kinase inhibitor reverses mesenchymal to epithelial phenotype and inhibits metastasis in inflammatory breast cancer. Clin Cancer Res. 2009 Nov 01; 15(21):6639-48. PMID: 19825949; PMCID: PMC2783487.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    431. Lee DF, Kuo HP, Liu M, Chou CK, Xia W, Du Y, Shen J, Chen CT, Huo L, Hsu MC, Li CW, Ding Q, Liao TL, Lai CC, Lin AC, Chang YH, Tsai SF, Li LY, Hung MC. KEAP1 E3 ligase-mediated downregulation of NF-kappaB signaling by targeting IKKbeta. Mol Cell. 2009 Oct 09; 36(1):131-40. PMID: 19818716; PMCID: PMC2770835.
      Citations: 160     Fields:    Translation:HumansAnimalsCells
    432. Kuo HP, Lee DF, Xia W, Wei Y, Hung MC. TNFalpha induces HIF-1alpha expression through activation of IKKbeta. Biochem Biophys Res Commun. 2009 Nov 27; 389(4):640-4. PMID: 19766100; PMCID: PMC2762003.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    433. Lu J, Guo H, Treekitkarnmongkol W, Li P, Zhang J, Shi B, Ling C, Zhou X, Chen T, Chiao PJ, Feng X, Seewaldt VL, Muller WJ, Sahin A, Hung MC, Yu D. 14-3-3zeta Cooperates with ErbB2 to promote ductal carcinoma in situ progression to invasive breast cancer by inducing epithelial-mesenchymal transition. Cancer Cell. 2009 Sep 08; 16(3):195-207. PMID: 19732720; PMCID: PMC2754239.
      Citations: 106     Fields:    Translation:HumansCells
    434. Jiralerspong S, Gonzalez-Angulo AM, Hung MC. Expanding the arsenal: metformin for the treatment of triple-negative breast cancer? Cell Cycle. 2009 Sep 01; 8(17):2681. PMID: 19717981.
      Citations: 10     Fields:    Translation:HumansCells
    435. Lee WH, Hung MC, Iczkowski KA, Languino LR, Dubinett SM, Wang D. The launch of the american journal of translational research. Am J Transl Res. 2009 Sep 01; 1(1):i. PMID: 19966932; PMCID: PMC2776285.
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    436. Kuo HP, Lee DF, Xia W, Lai CC, Li LY, Hung MC. Phosphorylation of ARD1 by IKKbeta contributes to its destabilization and degradation. Biochem Biophys Res Commun. 2009 Nov 06; 389(1):156-61. PMID: 19716809; PMCID: PMC2753275.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    437. Melnikova VO, Balasubramanian K, Villares GJ, Dobroff AS, Zigler M, Wang H, Petersson F, Price JE, Schroit A, Prieto VG, Hung MC, Bar-Eli M. Crosstalk between protease-activated receptor 1 and platelet-activating factor receptor regulates melanoma cell adhesion molecule (MCAM/MUC18) expression and melanoma metastasis. J Biol Chem. 2009 Oct 16; 284(42):28845-55. PMID: 19703903; PMCID: PMC2781430.
      Citations: 45     Fields:    Translation:HumansCells
    438. Xie X, Hsu JL, Choi MG, Xia W, Yamaguchi H, Chen CT, Trinh BQ, Lu Z, Ueno NT, Wolf JK, Bast RC, Hung MC. A novel hTERT promoter-driven E1A therapeutic for ovarian cancer. Mol Cancer Ther. 2009 Aug; 8(8):2375-82. PMID: 19671744; PMCID: PMC2759534.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    439. Sun HL, Tsai AC, Pan SL, Ding Q, Yamaguchi H, Lin CN, Hung MC, Teng CM. EPOX inhibits angiogenesis by degradation of Mcl-1 through ERK inactivation. Clin Cancer Res. 2009 Aug 01; 15(15):4904-14. PMID: 19622586.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    440. Xia W, Wei Y, Du Y, Liu J, Chang B, Yu YL, Huo LF, Miller S, Hung MC. Nuclear expression of epidermal growth factor receptor is a novel prognostic value in patients with ovarian cancer. Mol Carcinog. 2009 Jul; 48(7):610-7. PMID: 19058255; PMCID: PMC2718429.
      Citations: 85     Fields:    Translation:HumansCells
    441. Liu S, Umezu-Goto M, Murph M, Lu Y, Liu W, Zhang F, Yu S, Stephens LC, Cui X, Murrow G, Coombes K, Muller W, Hung MC, Perou CM, Lee AV, Fang X, Mills GB. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell. 2009 Jun 02; 15(6):539-50. PMID: 19477432; PMCID: PMC4157573.
      Citations: 207     Fields:    Translation:HumansAnimalsCells
    442. Jiralerspong S, Palla SL, Giordano SH, Meric-Bernstam F, Liedtke C, Barnett CM, Hsu L, Hung MC, Hortobagyi GN, Gonzalez-Angulo AM. Metformin and pathologic complete responses to neoadjuvant chemotherapy in diabetic patients with breast cancer. J Clin Oncol. 2009 Jul 10; 27(20):3297-302. PMID: 19487376; PMCID: PMC2736070.
      Citations: 351     Fields:    Translation:Humans
    443. Liao Y, Wei Y, Zhou X, Yang JY, Dai C, Chen YJ, Agarwal NK, Sarbassov D, Shi D, Yu D, Hung MC. Peptidyl-prolyl cis/trans isomerase Pin1 is critical for the regulation of PKB/Akt stability and activation phosphorylation. Oncogene. 2009 Jul 02; 28(26):2436-45. PMID: 19448664; PMCID: PMC2748248.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    444. Chen G, Izzo J, Demizu Y, Wang F, Guha S, Wu X, Hung MC, Ajani JA, Huang P. Different redox states in malignant and nonmalignant esophageal epithelial cells and differential cytotoxic responses to bile acid and honokiol. Antioxid Redox Signal. 2009 May; 11(5):1083-95. PMID: 19187006; PMCID: PMC2842128.
      Citations: 14     Fields:    Translation:HumansCells
    445. Cheng X, Hung MC. Regulation of breast cancer metastasis by atypical chemokine receptors. Clin Cancer Res. 2009 May 01; 15(9):2951-3. PMID: 19383808.
      Citations: 1     Fields:    Translation:HumansAnimals
    446. Hawthorne VS, Huang WC, Neal CL, Tseng LM, Hung MC, Yu D. ErbB2-mediated Src and signal transducer and activator of transcription 3 activation leads to transcriptional up-regulation of p21Cip1 and chemoresistance in breast cancer cells. Mol Cancer Res. 2009 Apr; 7(4):592-600. PMID: 19372587; PMCID: PMC2689096.
      Citations: 29     Fields:    Translation:HumansCells
    447. Neal CL, Yao J, Yang W, Zhou X, Nguyen NT, Lu J, Danes CG, Guo H, Lan KH, Ensor J, Hittelman W, Hung MC, Yu D. 14-3-3zeta overexpression defines high risk for breast cancer recurrence and promotes cancer cell survival. Cancer Res. 2009 Apr 15; 69(8):3425-32. PMID: 19318578; PMCID: PMC2671640.
      Citations: 94     Fields:    Translation:HumansCells
    448. Hsu SC, Miller SA, Wang Y, Hung MC. Nuclear EGFR is required for cisplatin resistance and DNA repair. Am J Transl Res. 2009 Mar 08; 1(3):249-58. PMID: 19956435; PMCID: PMC2776325.
      Citations: 53     
    449. Yamaguchi H, Woods NT, Piluso LG, Lee HH, Chen J, Bhalla KN, Monteiro A, Liu X, Hung MC, Wang HG. p53 acetylation is crucial for its transcription-independent proapoptotic functions. J Biol Chem. 2009 Apr 24; 284(17):11171-83. PMID: 19265193; PMCID: PMC2670122.
      Citations: 66     Fields:    Translation:HumansCells
    450. Huang WC, Hung MC. Induction of Akt activity by chemotherapy confers acquired resistance. J Formos Med Assoc. 2009 Mar; 108(3):180-94. PMID: 19293033.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
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