Sarah Zhang

Title	Graduate Student
Institution	Baylor College of Medicine
Department	Immunology & Microbiology
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Bibliographic

selected publications

Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.

PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.

Moosa A, Wang JJ, DeAngelis MM, Zhang SX. The MTRNR2L gene family and age-related macular degeneration. Front Immunol. 2026; 17:1925795. PMID: 42769495; PMCID: PMC13591426.

Citations:
Shao J, Bao X, Yaman I, Zheng Y, Wang J, Li J, Yang T, Jian J, Li J, Blackshaw S, Bharti K, Clarke M, Stambolian DE, Sung CH, Zheng JJ, Ortolan D, Zhang SX, Sharma R, Scheuermann RH, Pankajam AV, Ghobashi AH, Ma A, Ma Q, Futey M, Villani AC, Stout JT, DeAngelis MM, Chen H, Li Y, Chen R. An Integrated Multi-omics Single Cell Atlas of the Human RPE and Choroid. bioRxiv. 2026 Jul 24. PMID: 42539169; PMCID: PMC13419764.

Citations:
Acosta ML, Zhang SX, Palacios AG. Blood-retinal biomarker integration for precision prevention of Alzheimer's disease: Lessons from retinal aging and the unfolded protein response. Neural Regen Res. 2026 Nov 01; 21(11):5230-5231. PMID: 41778737.

Citations:
Stathopoulos A, Wang JJ, Martin SF, Zhang SX. Transmembrane Protein 97 (TMEM97): Molecular Target and Treatment in Age-Related Macular Degeneration (AMD). Biomolecules. 2025 08 26; 15(9). PMID: 41008535; PMCID: PMC12467532.

Citations:
Palacios AG, Zhang SX, Acosta ML. Diabetic retinopathy and Alzheimer's disease: Convergence of the unfolded protein response in neurodegeneration. Alzheimers Dement. 2025 08; 21(8):e70497. PMID: 40760071; PMCID: PMC12321509.

Citations:
Yera M, Wang JJ, Zhang SX. Protocol for real-time assessment of energy metabolism in dissociated mouse retinal photoreceptors using a SeahorseXFe24 analyzer. STAR Protoc. 2025 03 21; 6(1):103595. PMID: 39854204; PMCID: PMC11795547.

Citations:
Wang J, Lai DA, Wang JJ, Zhang SX. Effects of Nox4 upregulation on PECAM-1 expression in a mouse model of diabetic retinopathy. PLoS One. 2024; 19(5):e0303010. PMID: 38748682; PMCID: PMC11095704.

Citations:
Brenner B, Xu F, Zhang Y, Kweon J, Fang R, Sheibani N, Zhang SX, Sun C, Zhang HF. Quantifying nanoscopic alterations associated with mitochondrial dysfunction using three-dimensional single-molecule localization microscopy. Biomed Opt Express. 2024 Mar 01; 15(3):1571-1584. PMID: 38495683; PMCID: PMC10942681.

Citations:
Zhang SX, Wang JJ, Starr CR, Lee EJ, Park KS, Zhylkibayev A, Medina A, Lin JH, Gorbatyuk M. The endoplasmic reticulum: Homeostasis and crosstalk in retinal health and disease. Prog Retin Eye Res. 2024 01; 98:101231. PMID: 38092262; PMCID: PMC11056313.

Citations:
Shwani T, Zhang C, Owen LA, Shakoor A, Vitale AT, Lillvis JH, Barr JL, Cromwell P, Finley R, Husami N, Au E, Zavala RA, Graves EC, Zhang SX, Farkas MH, Ammar DA, Allison KM, Tawfik A, Sherva RM, Li M, Stambolian D, Kim IK, Farrer LA, DeAngelis MM. Patterns of Gene Expression, Splicing, and Allele-Specific Expression Vary among Macular Tissues and Clinical Stages of Age-Related Macular Degeneration. Cells. 2023 11 21; 12(23). PMID: 38067097; PMCID: PMC10705168.

Citations:
McLaughlin T, Wang G, Medina A, Perkins J, Nihlawi R, Seyfried D, Hu Z, Wang JJ, Zhang SX. Essential Role of XBP1 in Maintaining Photoreceptor Synaptic Integrity in Early Diabetic Retinopathy. Invest Ophthalmol Vis Sci. 2023 11 01; 64(14):40. PMID: 38015176; PMCID: PMC10691399.

Citations:
Lu T, Xie F, Huang C, Zhou L, Lai K, Gong Y, Li Z, Li L, Liang J, Cong Q, Li W, Ju R, Zhang SX, Jin C. ERp29 Attenuates Nicotine-Induced Endoplasmic Reticulum Stress and Inhibits Choroidal Neovascularization. Int J Mol Sci. 2023 Oct 24; 24(21). PMID: 37958506; PMCID: PMC10649101.

Citations:
McLaughlin T, Wang J, Jia L, Wu F, Wang Y, Wang JJ, Mu X, Zhang SX. Neuronal p58IPK Protects Retinal Ganglion Cells Independently of Macrophage/Microglia Activation in Ocular Hypertension. Cells. 2023 06 06; 12(12). PMID: 37371028; PMCID: PMC10297187.

Citations:
Tang X, Wang J, Abboud HE, Chen Y, Wang JJ, Zhang SX. Sustained Upregulation of Endothelial Nox4 Mediates Retinal Vascular Pathology in Type 1 Diabetes. Diabetes. 2023 01 01; 72(1):112-125. PMID: 36321974; PMCID: PMC9797318.

Citations:
Wang JJ, Park KS, Dhimal N, Shen S, Tang X, Qu J, Zhang SX. Proteomic Analysis of Retinal Mitochondria-Associated ER Membranes Identified Novel Proteins of Retinal Degeneration in Long-Term Diabetes. Cells. 2022 09 09; 11(18). PMID: 36139394; PMCID: PMC9497316.

Citations:
Hanineva A, Park KS, Wang JJ, DeAngelis MM, Farkas MH, Zhang SX. Emerging roles of circular RNAs in retinal diseases. Neural Regen Res. 2022 Sep; 17(9):1875-1880. PMID: 35142661; PMCID: PMC8848606.

Citations:
McLaughlin T, Medina A, Perkins J, Yera M, Wang JJ, Zhang SX. Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications. Mol Neurodegener. 2022 03 28; 17(1):25. PMID: 35346303; PMCID: PMC8962104.

Citations:
Zhang C, Owen LA, Lillvis JH, Zhang SX, Kim IK, DeAngelis MM. AMD Genomics: Non-Coding RNAs as Biomarkers and Therapeutic Targets. J Clin Med. 2022 Mar 09; 11(6). PMID: 35329812; PMCID: PMC8954267.

Citations:
Ying Y, Xue R, Yang Y, Zhang SX, Xiao H, Zhu H, Li J, Chen G, Ye Y, Yu M, Liu X, Zhong Y. Activation of ATF4 triggers trabecular meshwork cell dysfunction and apoptosis in POAG. Aging (Albany NY). 2021 03 10; 13(6):8628-8642. PMID: 33714955; PMCID: PMC8034903.

Citations:
Tang X, Wang JJ, Wang J, Abboud HE, Chen Y, Zhang SX. Endothelium-specific deletion of Nox4 delays retinal vascular development and mitigates pathological angiogenesis. Angiogenesis. 2021 05; 24(2):363-377. PMID: 33201372; PMCID: PMC8126573.

Citations:
Hunt KJ, Jenkins AJ, Fu D, Stevens D, Ma JX, Klein RL, Azar M, Zhang SX, Lopes-Virella MF, Lyons TJ, VADT Investigators. Serum pigment epithelium-derived factor: Relationships with cardiovascular events, renal dysfunction, and mortality in the Veterans Affairs Diabetes Trial (VADT) cohort. J Diabetes Complications. 2019 10; 33(10):107410. PMID: 31434620; PMCID: PMC6786884.

Citations: 2 Fields:
End Endocrinology
Translation:Humans
McLaughlin T, Siddiqi M, Wang JJ, Zhang SX. Loss of XBP1 Leads to Early-Onset Retinal Neurodegeneration in a Mouse Model of Type I Diabetes. J Clin Med. 2019 Jun 25; 8(6). PMID: 31242599; PMCID: PMC6617367.

Citations:
Yang J, Chen C, McLaughlin T, Wang Y, Le YZ, Wang JJ, Zhang SX. Loss of X-box binding protein 1 in M?ller cells augments retinal inflammation in a mouse model of diabetes. Diabetologia. 2019 03; 62(3):531-543. PMID: 30612139; PMCID: PMC6374194.

Citations:
Chen C, Zhong Y, Wang JJ, Yu Q, Plafker K, Plafker S, Zhang SX. Regulation of Nrf2 by X Box-Binding Protein 1 in Retinal Pigment Epithelium. Front Genet. 2018; 9:658. PMID: 30619478; PMCID: PMC6306429.

Citations:
Kelly K, Wang JJ, Zhang SX. The unfolded protein response signaling and retinal M?ller cell metabolism. Neural Regen Res. 2018 Nov; 13(11):1861-1870. PMID: 30233053; PMCID: PMC6183030.

Citations:
McLaughlin T, Dhimal N, Li J, Wang JJ, Zhang SX. p58IPK Is an Endogenous Neuroprotectant for Retinal Ganglion Cells. Front Aging Neurosci. 2018; 10:267. PMID: 30245625; PMCID: PMC6137320.

Citations:
Bhatta M, Chatpar K, Hu Z, Wang JJ, Zhang SX. Reduction of Endoplasmic Reticulum Stress Improves Angiogenic Progenitor Cell function in a Mouse Model of Type 1 Diabetes. Cell Death Dis. 2018 05 01; 9(5):467. PMID: 29700294; PMCID: PMC5920101.

Citations:
McLaughlin T, Falkowski M, Park JW, Keegan S, Elliott M, Wang JJ, Zhang SX. Loss of XBP1 accelerates age-related decline in retinal function and neurodegeneration. Mol Neurodegener. 2018 04 04; 13(1):16. PMID: 29615095; PMCID: PMC5883257.

Citations:
McLaughlin T, Falkowski M, Wang JJ, Zhang SX. Molecular Chaperone ERp29: A Potential Target for Cellular Protection in Retinal and Neurodegenerative Diseases. Adv Exp Med Biol. 2018; 1074:421-427. PMID: 29721972; PMCID: PMC6040649.

Citations:
Ma JH, Shen S, Wang JJ, He Z, Poon A, Li J, Qu J, Zhang SX. Comparative Proteomic Analysis of the Mitochondria-associated ER Membrane (MAM) in a Long-term Type 2 Diabetic Rodent Model. Sci Rep. 2017 05 18; 7(1):2062. PMID: 28522876; PMCID: PMC5437025.

Citations:
Ma JH, Wang JJ, Li J, Pfeffer BA, Zhong Y, Zhang SX. The Role of IRE-XBP1 Pathway in Regulation of Retinal Pigment Epithelium Tight Junctions. Invest Ophthalmol Vis Sci. 2016 Oct 01; 57(13):5244-5252. PMID: 27701635; PMCID: PMC5054729.

Citations:
Boriushkin E, Wang JJ, Li J, Bhatta M, Zhang SX. p58(IPK) suppresses NLRP3 inflammasome activation and IL-1? production via inhibition of PKR in macrophages. Sci Rep. 2016 04 26; 6:25013. PMID: 27113095; PMCID: PMC4845006.

Citations:
Gardner AW, Parker DE, Montgomery PS, Sosnowska D, Casanegra AI, Ungvari Z, Csiszar A, Zhang SX, Wang JJ, Sonntag WE. INFLUENCE OF DIABETES ON AMBULATION AND INFLAMMATION IN MEN AND WOMEN WITH SYMPTOMATIC PERIPHERAL ARTERY DISEASE. J Clin Transl Endocrinol. 2015 Dec 01; 2(4):137-143. PMID: 26835254; PMCID: PMC4730895.

Citations:
Huang C, Wang JJ, Jing G, Li J, Jin C, Yu Q, Falkowski MW, Zhang SX. Erp29 Attenuates Cigarette Smoke Extract-Induced Endoplasmic Reticulum Stress and Mitigates Tight Junction Damage in Retinal Pigment Epithelial Cells. Invest Ophthalmol Vis Sci. 2015 Oct; 56(11):6196-207. PMID: 26431474; PMCID: PMC4594532.

Citations:
McLaughlin T, Zhang SX. The neuroprotective potential of endoplasmic reticulum chaperones. Neural Regen Res. 2015 Aug; 10(8):1211-3. PMID: 26487839; PMCID: PMC4590224.

Citations:
Yu M, Kang K, Bu P, Bell BA, Kaul C, Qiao JB, Sturgill-Short G, Yu X, Tarchick MJ, Beight C, Zhang SX, Peachey NS. Deficiency of CC chemokine ligand 2 and decay-accelerating factor causes retinal degeneration in mice. Exp Eye Res. 2015 Sep; 138:126-33. PMID: 26149093; PMCID: PMC5509212.

Citations:
Bhatta M, Ma JH, Wang JJ, Sakowski J, Zhang SX. Enhanced endoplasmic reticulum stress in bone marrow angiogenic progenitor cells in a mouse model of long-term experimental type 2 diabetes. Diabetologia. 2015 Sep; 58(9):2181-90. PMID: 26063198; PMCID: PMC4529381.

Citations:
Huang H, Jing G, Wang JJ, Sheibani N, Zhang SX. ATF4 is a novel regulator of MCP-1 in microvascular endothelial cells. J Inflamm (Lond). 2015; 12:31. PMID: 25914608; PMCID: PMC4409760.

Citations:
Li J, Wang JJ, Zhang SX. NADPH oxidase 4-derived H2O2 promotes aberrant retinal neovascularization via activation of VEGF receptor 2 pathway in oxygen-induced retinopathy. J Diabetes Res. 2015; 2015:963289. PMID: 25866826; PMCID: PMC4381975.

Citations:
Boriushkin E, Wang JJ, Li J, Jing G, Seigel GM, Zhang SX. Identification of p58IPK as a novel neuroprotective factor for retinal neurons. Invest Ophthalmol Vis Sci. 2015 Feb 05; 56(2):1374-86. PMID: 25655802; PMCID: PMC4340432.

Citations:
Huang C, Wang JJ, Ma JH, Jin C, Yu Q, Zhang SX. Activation of the UPR protects against cigarette smoke-induced RPE apoptosis through up-regulation of Nrf2. J Biol Chem. 2015 Feb 27; 290(9):5367-80. PMID: 25568320; PMCID: PMC4342454.

Citations:
Zhang SX, Ma JH, Bhatta M, Fliesler SJ, Wang JJ. The unfolded protein response in retinal vascular diseases: implications and therapeutic potential beyond protein folding. Prog Retin Eye Res. 2015 Mar; 45:111-31. PMID: 25529848; PMCID: PMC4339403.

Citations:
Ma JH, Wang JJ, Zhang SX. The unfolded protein response and diabetic retinopathy. J Diabetes Res. 2014; 2014:160140. PMID: 25530974; PMCID: PMC4229964.

Citations:
Tryggestad JB, Wang JJ, Zhang SX, Thompson DM, Short KR. Elevated plasma pigment epithelium-derived factor in children with type 2 diabetes mellitus is attributable to obesity. Pediatr Diabetes. 2015 Dec; 16(8):600-5. PMID: 25293868; PMCID: PMC8327465.

Citations:
Zhang SX, Sanders E, Fliesler SJ, Wang JJ. Endoplasmic reticulum stress and the unfolded protein responses in retinal degeneration. Exp Eye Res. 2014 Aug; 125:30-40. PMID: 24792589; PMCID: PMC4122592.

Citations:
Boriushkin E, Wang JJ, Zhang SX. Role of p58IPK in Endoplasmic Reticulum Stress-associated Apoptosis and Inflammation. J Ophthalmic Vis Res. 2014 Jan; 9(1):134-43. PMID: 24982747; PMCID: PMC4074489.

Citations:
Chen C, Cano M, Wang JJ, Li J, Huang C, Yu Q, Herbert TP, Handa JT, Zhang SX. Role of unfolded protein response dysregulation in oxidative injury of retinal pigment epithelial cells. Antioxid Redox Signal. 2014 May 10; 20(14):2091-106. PMID: 24053669; PMCID: PMC3995121.

Citations:
Buck HG, Akbar JA, Zhang SJ, Bettger JA. Measuring comorbidity in cardiovascular research: a systematic review. Nurs Res Pract. 2013; 2013:563246. PMID: 23956853; PMCID: PMC3730163.

Citations:
Wang JJ, Zhang SX, Mott R, Chen Y, Knapp RR, Cao W, Ma JX. Anti-inflammatory effects of pigment epithelium-derived factor in diabetic nephropathy. Am J Physiol Renal Physiol. 2008 May; 294(5):F1166-73. PMID: 18322021.

Citations:

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