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SUSAN HAMILTON

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Integrative Physiology
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleChair
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Integrative Physiology
    DivisionMolecular Physiology & Biophysics


    Collapse Research 
    Collapse research activities and funding
    R01AR072602     (HAMILTON, SUSAN L ;HORRIGAN, FRANK T;JUNG, SUNG YUN;RIOS, EDUARDO)Aug 1, 2018 - Jun 30, 2023
    NIH
    Mechanisms of couplon-linked skeletal muscle myopathies
    Role: Principal Investigator
    R01AR072475     (DIRKSEN, ROBERT T;HAMILTON, SUSAN L ;JUNG, SUNG YUN)Mar 22, 2018 - Feb 29, 2024
    NIH
    Redefining the Role of FKBP12 in Skeletal Muscle
    Role: Principal Investigator
    R01AR053349     (HAMILTON, SUSAN L)Dec 1, 2005 - Mar 31, 2021
    NIH
    Basis of Muscle Dysfunction in Malignant Hyperthermia & Central Core Disease
    Role: Principal Investigator
    R13AR053443     (HAMILTON, SUSAN L)Sep 30, 2005 - Aug 31, 2006
    NIH
    2006 Muscle: Excitation/Contraction Coupling Gordan Conference
    Role: Principal Investigator
    R01AR050503     (HAMILTON, SUSAN L)Jan 15, 2004 - Dec 31, 2009
    NIH
    Nitrosylation and Oxidation of RYR1 in Muscle Function
    Role: Principal Investigator
    R13AR050615     (HAMILTON, SUSAN L)Sep 29, 2003 - Oct 2, 2003
    NIH
    Calcium Release and Cellular Calcium Signaling Domains
    Role: Principal Investigator
    R01AR044864     (HAMILTON, SUSAN L)Sep 27, 1999 - Aug 31, 2010
    NIH
    Molecular Determinants of E-C Coupling
    Role: Principal Investigator
    R01AR041729     (HAMILTON, SUSAN L)Jun 1, 1996 - Sep 30, 2003
    NIH
    STRUCTURAL ANALYSIS OF THE CA++ RELEASE CHANNEL
    Role: Principal Investigator
    R01AR041802     (HAMILTON, SUSAN L)Aug 1, 1993 - Nov 30, 2015
    NIH
    Modulation of Sarcoplasmic Reticulum Calcium Release
    Role: Principal Investigator
    R55AR041729     (HAMILTON, SUSAN L)Sep 1, 1992 - Mar 31, 1995
    NIH
    STRUCTURE-FUNCTION OF MUTANT CA2+ RELEASE CHANNELS
    Role: Principal Investigator
    U09RG000141     (ALMO, STEVEN C.)Jun 1, 1991 - Sep 29, 2006
    NIH
    DIVISION OF MOLECULAR AND CELLULAR MECHANISMS SEPS
    Role: Co-Principal Investigator
    T32HL007676     (HAMILTON, SUSAN L)Jul 1, 1989 - Jun 30, 2021
    NIH
    Molecular Physiology of the Cardiovascular System
    Role: Principal Investigator
    K04HL002063     (HAMILTON, SUSAN L)Mar 1, 1988 - Feb 28, 1993
    NIH
    DIHYDROPYRIDINE BINDING SITES AND CALCIUM CHANNELS
    Role: Principal Investigator
    R01HL037028     (HAMILTON, SUSAN L)Dec 1, 1985 - Feb 28, 1993
    NIH
    DIHYDROPYRIDINE BINDING SITES AND CALCIUM CHANNELS
    Role: Principal Investigator
    R01HL032935     (HAMILTON, SUSAN L)Aug 1, 1984 - Nov 30, 1985
    NIH
    DIHYDROPYRIDINE BINDING SITES AND CALCIUM CHANNELS
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Lee CS, Jung SY, Yee RSZ, Agha NH, Hong J, Chang T, Babcock LW, Fleischman JD, Clayton B, Hanna AD, Ward CS, Lanza D, Hurley AE, Zhang P, Wehrens XHT, Lagor WR, Rodney GG, Hamilton SL. Speg interactions that regulate the stability of excitation-contraction coupling protein complexes in triads and dyads. Commun Biol. 2023 09 14; 6(1):942. PMID: 37709832; PMCID: PMC10502019.
      Citations:    Translation:Animals
    2. Endo Y, Groom L, Celik A, Kraeva N, Lee CS, Jung SY, Gardner L, Shaw MA, Hamilton SL, Hopkins PM, Dirksen RT, Riazi S, Dowling JJ. Variants in ASPH cause exertional heat illness and are associated with malignant hyperthermia susceptibility. Nat Commun. 2022 06 13; 13(1):3403. PMID: 35697689; PMCID: PMC9192596.
      Citations:    Fields:    Translation:HumansAnimalsCells
    3. Hanna AD, Lee CS, Babcock L, Wang H, Recio J, Hamilton SL. Pathological mechanisms of vacuolar aggregate myopathy arising from a Casq1 mutation. FASEB J. 2021 05; 35(5):e21349. PMID: 33786938; PMCID: PMC8138327.
      Citations:    Fields:    Translation:AnimalsCells
    4. Baker ML, Dirksen RT, Hamilton SL. How mutations in RYR1 that cause malignant hyperthermia increase RYR1 sensitivity to activators. Cell Calcium. 2021 Apr 19; 97:102412. PMID: 33905995.
      Citations:    Fields:    
    5. Bojko B, Vasiljevic T, Boyaci E, Roszkowska A, Kraeva N, Ibarra Moreno CA, Koivu A, Wasowicz M, Hanna A, Hamilton S, Riazi S, Pawliszyn J. Untargeted metabolomics profiling of skeletal muscle samples from malignant hyperthermia susceptible patients. Can J Anaesth. 2021 06; 68(6):761-772. PMID: 33403543; PMCID: PMC8185566.
      Citations: 1     Fields:    Translation:Humans
    6. Lawal TA, Todd JJ, Witherspoon JW, Dowling JJ, Hamilton SL, Meilleur KG, Dirksen RT, B?nnemann CG. Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature. Skelet Muscle. 2020 11 16; 10(1):32. PMID: 33190635; PMCID: PMC7667763.
      Citations: 9     Fields:    Translation:HumansAnimals
    7. Babcock LW, Hanna AD, Agha NH, Hamilton SL. MyoSight-semi-automated image analysis of skeletal muscle cross sections. Skelet Muscle. 2020 11 16; 10(1):33. PMID: 33198807; PMCID: PMC7667765.
      Citations: 2     Fields:    Translation:AnimalsCells
    8. Wang HJ, Lee CS, Yee RSZ, Groom L, Friedman I, Babcock L, Georgiou DK, Hong J, Hanna AD, Recio J, Choi JM, Chang T, Agha NH, Romero J, Sarkar P, Voermans N, Gaber MW, Jung SY, Baker ML, Pautler RG, Dirksen RT, Riazi S, Hamilton SL. Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation. Nat Commun. 2020 10 09; 11(1):5099. PMID: 33037202; PMCID: PMC7547078.
      Citations: 5     Fields:    Translation:HumansAnimals
    9. Hanna A, Hamilton S, Vanden Abeele F, Lotteau S, Ducreux S, Dubois C, Monnier N, Gkika D, Romestaing C, Noyer L, Flourakis M, Tessier N, Al-Mawla R, Chouabe C, Lefai E, Lunardi J, Faur? J, Van Coppenolle F, Prevarskaya N. TRPV1 variants impair intracellular Ca2+ signaling and may confer susceptibility to malignant hyperthermia. Genet Med. 2019 02; 21(2):441-450. PMID: 29930394; PMCID: PMC6752298.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    10. Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SL. A chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659. PMID: 28337975; PMCID: PMC5376670.
      Citations: 34     Fields:    Translation:AnimalsCells
    11. Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. J Biol Chem. 2015 Sep 25; 290(39):23751-65. PMID: 26245899; PMCID: PMC4583036.
      Citations: 21     Fields:    Translation:AnimalsCells
    12. Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, Dickinson ME, Beeton C, Zhang P, Dirksen RT, Hamilton SL, Poch? RA. Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skelet Muscle. 2015; 5:4. PMID: 25717360; PMCID: PMC4340672.
      Citations: 29     Fields:    
    13. Pedrotti S, Giudice J, Dagnino-Acosta A, Knoblauch M, Singh RK, Hanna A, Mo Q, Hicks J, Hamilton S, Cooper TA. The RNA-binding protein Rbfox1 regulates splicing required for skeletal muscle structure and function. Hum Mol Genet. 2015 Apr 15; 24(8):2360-74. PMID: 25575511; PMCID: PMC4380076.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    14. Lee CS, Georgiou DK, Dagnino-Acosta A, Xu J, Ismailov II, Knoblauch M, Monroe TO, Ji R, Hanna AD, Joshi AD, Long C, Oakes J, Tran T, Corona BT, Lorca S, Ingalls CP, Narkar VA, Lanner JT, Bayle JH, Durham WJ, Hamilton SL. Ligands for FKBP12 increase Ca2+ influx and protein synthesis to improve skeletal muscle function. J Biol Chem. 2014 Sep 12; 289(37):25556-70. PMID: 25053409; PMCID: PMC4162161.
      Citations: 10     Fields:    Translation:AnimalsCells
    15. Longwell JJ, Bedocs P, Sambuughin N, Bina S, Cooper PB, Carroll CG, O'Connor F, Deuster P, Muldoon SM, Hamilton S, Capacchione JF, Potts LE. Improving awareness of nonanesthesia-related malignant hyperthermia presentations: a tale of two brothers. A A Case Rep. 2014 Jul 15; 3(2):23-6. PMID: 25611019.
      Citations: 4     Fields:    
    16. Sambuughin N, Zvaritch E, Kraeva N, Sizova O, Sivak E, Dickson K, Weglinski M, Capacchione J, Muldoon S, Riazi S, Hamilton S, Brandom B, MacLennan DH. Exome analysis identifies Brody myopathy in a family diagnosed with malignant hyperthermia susceptibility. Mol Genet Genomic Med. 2014 Nov; 2(6):472-83. PMID: 25614869; PMCID: PMC4303217.
      Citations:    
    17. Knoblauch M, Dagnino-Acosta A, Hamilton SL. Mice with RyR1 mutation (Y524S) undergo hypermetabolic response to simvastatin. Skelet Muscle. 2013 Sep 03; 3(1):22. PMID: 24004537; PMCID: PMC3846650.
      Citations: 14     Fields:    
    18. Figueroa L, Royer L, Pouvreau S, Lee CS, Volpe P, Nori A, Zhou J, Meissner G, Hamilton SL, Manno C, R?os E. Altered Ca2+ concentration, permeability and buffering in the myofibre Ca2+ store of a mouse model of malignant hyperthermia. J Physiol. 2013 Sep 15; 591(18):4439-57. PMID: 23798496; PMCID: PMC3784192.
      Citations: 17     Fields:    Translation:AnimalsCells
    19. Lalani SR, Ware SM, Wang X, Zapata G, Tian Q, Franco LM, Jiang Z, Bucasas K, Scott DA, Campeau PM, Hanchard N, Cast A, Patel A, Cheung SW, McBride KL, Bray M, Craig Chinault A, Boggs BA, Huang M, Baker MR, Hamilton S, Towbin J, Jefferies JL, Fernbach SD, Potocki L, Belmont JW, Uma?a L. MCTP2 is a dosage-sensitive gene required for cardiac outflow tract development. Hum Mol Genet. 2013 Nov 01; 22(21):4339-48. PMID: 23773997; PMCID: PMC3792692.
      Citations: 17     Fields:    Translation:HumansAnimals
    20. Sambuughin N, Liu X, Bijarnia S, Wallace T, Verma IC, Hamilton S, Muldoon S, Tallon LJ, Wang S. Exome sequencing reveals SCO2 mutations in a family presented with fatal infantile hyperthermia. J Hum Genet. 2013 Apr; 58(4):226-8. PMID: 23364397.
      Citations:    
    21. Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, Rodney GG, Dirksen RT, Hamilton SL. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nat Med. 2012 Jan 08; 18(2):244-51. PMID: 22231556; PMCID: PMC3274651.
      Citations: 55     Fields:    Translation:AnimalsCells
    22. Lanner JT, Georgiou DK, Joshi AD, Hamilton SL. Ryanodine receptors: structure, expression, molecular details, and function in calcium release. Cold Spring Harb Perspect Biol. 2010 Nov; 2(11):a003996. PMID: 20961976; PMCID: PMC2964179.
      Citations: 296     Fields:    Translation:HumansAnimalsCells
    23. Corona BT, Hamilton SL, Ingalls CP. Effect of prior exercise on thermal sensitivity of malignant hyperthermia-susceptible muscle. Muscle Nerve. 2010 Aug; 42(2):270-2. PMID: 20544946; PMCID: PMC2980915.
      Citations: 5     Fields:    Translation:Animals
    24. Rossi AE, Micaroni M, Hamilton SL, Dirksen RT, Franzini-Armstrong C, Protasi F, Boncompagni S. Characterization and temporal development of cores in a mouse model of malignant hyperthermia. Proc Natl Acad Sci U S A. 2009 Dec 22; 106(51):21996-2001. PMID: 19966218; PMCID: PMC2799858.
      Citations: 57     Fields:    Translation:AnimalsCells
    25. Halling DB, Georgiou DK, Black DJ, Yang G, Fallon JL, Quiocho FA, Pedersen SE, Hamilton SL. Determinants in CaV1 channels that regulate the Ca2+ sensitivity of bound calmodulin. J Biol Chem. 2009 Jul 24; 284(30):20041-51. PMID: 19473981; PMCID: PMC2740430.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    26. Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FA. Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins. Proc Natl Acad Sci U S A. 2009 Mar 31; 106(13):5135-40. PMID: 19279214; PMCID: PMC2654391.
      Citations: 58     Fields:    Translation:HumansCells
    27. Andronache Z, Hamilton SL, Dirksen RT, Melzer W. A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice. Proc Natl Acad Sci U S A. 2009 Mar 17; 106(11):4531-6. PMID: 19246389; PMCID: PMC2657461.
      Citations: 40     Fields:    Translation:AnimalsCells
    28. Hoeffer CA, Tang W, Wong H, Santillan A, Patterson RJ, Martinez LA, Tejada-Simon MV, Paylor R, Hamilton SL, Klann E. Removal of FKBP12 enhances mTOR-Raptor interactions, LTP, memory, and perseverative/repetitive behavior. Neuron. 2008 Dec 10; 60(5):832-45. PMID: 19081378; PMCID: PMC2630531.
      Citations: 111     Fields:    Translation:AnimalsCells
    29. Hamilton SL, Serysheva II. Ryanodine receptor structure: progress and challenges. J Biol Chem. 2009 Feb 13; 284(7):4047-51. PMID: 18927076; PMCID: PMC3837402.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    30. Corona BT, Rouviere C, Hamilton SL, Ingalls CP. Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice. J Appl Physiol (1985). 2008 Nov; 105(5):1542-53. PMID: 18787086; PMCID: PMC2584836.
      Citations: 12     Fields:    Translation:AnimalsCells
    31. Serysheva II, Ludtke SJ, Baker ML, Cong Y, Topf M, Eramian D, Sali A, Hamilton SL, Chiu W. Subnanometer-resolution electron cryomicroscopy-based domain models for the cytoplasmic region of skeletal muscle RyR channel. Proc Natl Acad Sci U S A. 2008 Jul 15; 105(28):9610-5. PMID: 18621707; PMCID: PMC2474495.
      Citations: 61     Fields:    Translation:Cells
    32. Corona BT, Rouviere C, Hamilton SL, Ingalls CP. FKBP12 deficiency reduces strength deficits after eccentric contraction-induced muscle injury. J Appl Physiol (1985). 2008 Aug; 105(2):527-37. PMID: 18511525; PMCID: PMC2519949.
      Citations: 7     Fields:    Translation:Animals
    33. Durham WJ, Aracena-Parks P, Long C, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman CP, Baker MR, Shirokova N, Protasi F, Dirksen R, Hamilton SL. RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice. Cell. 2008 Apr 04; 133(1):53-65. PMID: 18394989; PMCID: PMC2366094.
      Citations: 165     Fields:    Translation:HumansAnimalsCells
    34. Huddleston AT, Tang W, Takeshima H, Hamilton SL, Klann E. Superoxide-induced potentiation in the hippocampus requires activation of ryanodine receptor type 3 and ERK. J Neurophysiol. 2008 Mar; 99(3):1565-71. PMID: 18199822.
      Citations: 33     Fields:    Translation:AnimalsCells
    35. Long C, Cook LG, Hamilton SL, Wu GY, Mitchell BM. FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure. Hypertension. 2007 Mar; 49(3):569-76. PMID: 17261647.
      Citations: 23     Fields:    Translation:AnimalsCells
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