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LAWRENCE CHAN

TitleDistinguished Emeritus Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Medicine
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Biochemistry and Molecular Pharmacology
    DivisionBiochemistry & Mol Pharmacology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology

    TitleDistinguished Emeritus Professor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Human Genetics
    DivisionMolecular & Human Genetics


    Collapse Research 
    Collapse research activities and funding
    P30DK079638     (CHAN, LAWRENCE)Mar 20, 2008 - Jan 31, 2015
    NIH
    Diabetes Endocrinology Research Center
    Role: Principal Investigator
    R21DK075002     (CHAN, LAWRENCE)Apr 15, 2006 - Mar 31, 2010
    NIH
    Induced islet neogenesis therapy in vivo
    Role: Principal Investigator
    T32HL066991     (CHAN, LAWRENCE)Apr 1, 2001 - Aug 31, 2014
    NIH
    Molecular Medicine Scholars Training Grant
    Role: Principal Investigator
    P01HL059314     (CHAN, LAWRENCE)Sep 30, 1997 - Dec 31, 2008
    NIH
    PATHOBIOLOGY AND GENE TRANSFER IN CARDIOVASCULAR DISEASE
    Role: Principal Investigator
    P50HL059314     (CHAN, LAWRENCE)Sep 30, 1997 - Aug 31, 2003
    NIH
    PATHOBIOLOGY AND GENE TRANSFER IN CARDIOVASCULAR DISEASE
    Role: Principal Investigator
    R01HL056668     (CHAN, LAWRENCE)Aug 1, 1996 - Jul 31, 2005
    NIH
    APOLIPOPROTEIN B48 AND LIPOPROTEIN METABOLISM
    Role: Principal Investigator
    R01HL051586     (CHAN, LAWRENCE)Dec 15, 1993 - Apr 30, 2016
    NIH
    Animal Models for Lipid Metabolism
    Role: Principal Investigator
    R01HL045516     (CHAN, LAWRENCE)Jan 1, 1991 - Dec 31, 1994
    NIH
    MECHANISM OF APOLIPOPROTEIN B-48 BIOGENESIS
    Role: Principal Investigator
    S10RR004655     (CHAN, LAWRENCE)Apr 12, 1989 - Apr 11, 1990
    NIH
    DNA SEQUENCING SYSTEM
    Role: Principal Investigator
    R01ES003269     (CHAN, LAWRENCE)Feb 1, 1984 - Jan 31, 1987
    NIH
    CHEMICAL HEPATOTOXICITY
    Role: Principal Investigator
    R01DK068037     (CHAN, LAWRENCE)May 1, 1979 - Jul 31, 2010
    NIH
    NOVEL THERAPY FOR DIABETES
    Role: Principal Investigator
    R01HL016512     (CHAN, LAWRENCE)May 1, 1979 - Aug 31, 2005
    NIH
    LIPOPROTEIN METABOLISM AND HORMONAL REGULATION
    Role: Principal Investigator
    R37HL016512     (CHAN, LAWRENCE)May 1, 1979 - Apr 30, 1999
    NIH
    LIPOPROTEIN METABOLISM AND HORMONAL REGULATION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Van Patten R, Chan L, Tocco K, Mordecai K, Altalib H, Cotton E, Correia S, Gaston TE, Grayson LP, Martin A, Fry S, Goodman A, Allendorfer JB, Szaflarski J, LaFrance WC. Reduced Subjective Cognitive Concerns With Neurobehavioral Therapy in Functional Seizures and Traumatic Brain Injury. J Neuropsychiatry Clin Neurosci. 2024 Mar 14; appineuropsych20230138. PMID: 38481168.
      Citations:    Fields:    
    2. Weng X, Song F, Tang M, Wang K, Zhang Y, Miao Y, Chan LW, Lei P, Hu Z, Yang F. MDM-U-Net: A novel network for renal cancer structure segmentation. Comput Med Imaging Graph. 2023 10; 109:102301. PMID: 37738774.
      Citations:    Fields:    Translation:Humans
    3. Li JM, Li X, Chan LWC, Hu R, Zheng T, Li H, Yang S. Lipotoxicity-polarised macrophage-derived exosomes regulate mitochondrial fitness through Miro1-mediated mitophagy inhibition and contribute to type 2 diabetes development in mice. Diabetologia. 2023 12; 66(12):2368-2386. PMID: 37615690.
      Citations: 5     Fields:    Translation:AnimalsCells
    4. Huang M, Yang S, Tai WCS, Zhang L, Zhou Y, Cho WCS, Chan LWC, Wong SCC. Bioinformatics Identification of Regulatory Genes and Mechanism Related to Hypoxia-Induced PD-L1 Inhibitor Resistance in Hepatocellular Carcinoma. Int J Mol Sci. 2023 May 13; 24(10). PMID: 37240068; PMCID: PMC10218698.
      Citations:    Fields:    Translation:Humans
    5. Wu Y, Liu Q, Wang Y, Li F, Chan LW, Wen Y, Yang F, Xiang Y, Duan Q, Luo P, Lei P. Diagnostic efficiency on ultrasound shear wave elastography in evaluation of steatosis severity for non-alcoholic fatty liver disease: a rat model. Eur J Med Res. 2023 Feb 11; 28(1):75. PMID: 36774529; PMCID: PMC9921353.
      Citations: 1     Fields:    Translation:Animals
    6. Li JM, Li X, Chan LWC, Hu R, Yang S. A high fat diet in glutamate 3-/Y mice causes changes in behavior that resemble human intellectual disability. Physiol Behav. 2023 02 01; 259:114050. PMID: 36476780.
      Citations: 1     Fields:    Translation:HumansAnimals
    7. Frank B, Ally M, Tripodis Y, Puzo C, Hurley L, Martin B, Palmisano J, Chan L, Steinberg E, Turk K, Budson A, O'Connor M, Au R, Qiu WQ, Goldstein L, Kukull W, Kowall N, Killiany R, Stern R, Stein T, McKee A, Mez J, Alosco M, Labriola C. Trajectories of Cognitive Decline in Brain Donors With Autopsy-Confirmed Alzheimer Disease and Cerebrovascular Disease. Neurology. 2022 06 14; 98(24):e2454-e2464. PMID: 35444054; PMCID: PMC9231841.
      Citations:    Fields:    Translation:Humans
    8. Huang L, Lin W, Xie D, Yu Y, Cao H, Liao G, Wu S, Yao L, Wang Z, Wang M, Wang S, Wang G, Zhang D, Yao S, He Z, Cho WC, Chen D, Zhang Z, Li W, Qiao G, Chan LW, Zhou H. Development and validation of a preoperative CT-based radiomic nomogram to predict pathology invasiveness in patients with a solitary pulmonary nodule: a machine learning approach, multicenter, diagnostic study. Eur Radiol. 2022 Mar; 32(3):1983-1996. PMID: 34654966; PMCID: PMC8831242.
      Citations:    
    9. Zhu H, Xie D, Yu Y, Yao L, Xu B, Huang L, Wu S, Li F, Zheng Y, Liu X, Xie W, Huang M, Li H, Zheng S, Zhang D, Qiao G, Chan LWC, Zhou H. KEAP1/NFE2L2 Mutations of Liquid Biopsy as Prognostic Biomarkers in Patients With Advanced Non-Small Cell Lung Cancer: Results From Two Multicenter, Randomized Clinical Trials. Front Oncol. 2021; 11:659200. PMID: 34381706; PMCID: PMC8350725.
      Citations: 3     
    10. Li X, Chan LWC, Li X, Liu C, Yang G, Gao J, Dai M, Wang Y, Xie Z, Liu J, Zhou F, Zheng T, Feng D, Guo S, Li H, Sun K, Yang S. Obesity-Induced Regulator of Calcineurin 1 Overexpression Leads to ?-Cell Failure Through Mitophagy Pathway Inhibition. Antioxid Redox Signal. 2020 03 01; 32(7):413-428. PMID: 31822118.
      Citations: 4     Fields:    Translation:AnimalsCells
    11. Wang F, Meng F, Wong SCC, Cho WCS, Yang S, Chan LWC. Combination therapy of gefitinib and miR-30a-5p may overcome acquired drug resistance through regulating the PI3K/AKT pathway in non-small cell lung cancer. Ther Adv Respir Dis. 2020 Jan-Dec; 14:1753466620915156. PMID: 32552611; PMCID: PMC7303773.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    12. Ogawa N, Terashima T, Oka K, Chan L, Kojima H. Gene therapy for neuropathic pain using dorsal root ganglion-targeted helper-dependent adenoviral vectors with GAD67 expression. Pain Rep. 2018 Nov; 3(6):e695. PMID: 30706038; PMCID: PMC6344132.
      Citations: 4     
    13. Chan LW, Wang F, Meng F, Wang L, Wong SCC, Au JS, Yang S, Cho WC. Multi-scale representation of proteomic data exhibits distinct microRNA regulatory modules in non-smoking female patients with lung adenocarcinoma. Comput Biol Med. 2018 11 01; 102:51-56. PMID: 30245277.
      Citations:    Fields:    Translation:Humans
    14. Tam BT, Yu AP, Tam EW, Monks DA, Wang XP, Pei XM, Koh SP, Sin TK, Law HKW, Ugwu FN, Supriya R, Yung BY, Yip SP, Wong SC, Chan LW, Lai CW, Ouyang P, Siu PM. Ablation of Bax and Bak protects skeletal muscle against pressure-induced injury. Sci Rep. 2018 02 27; 8(1):3689. PMID: 29487339; PMCID: PMC5829134.
      Citations: 3     Fields:    Translation:Animals
    15. Wei Q, Lee JH, Wang H, Bongmba OYN, Wu CS, Pradhan G, Sun Z, Chew L, Bajaj M, Chan L, Chapkin RS, Chen MH, Sun Y. Adiponectin is required for maintaining normal body temperature in a cold environment. BMC Physiol. 2017 Oct 23; 17(1):8. PMID: 29058611; PMCID: PMC5651620.
      Citations: 11     Fields:    Translation:Animals
    16. Xie A, Li R, Jiang T, Yan H, Zhang H, Yang Y, Yang L, Yechoor V, Chan L, Chen W. Anti-TCR? mAb in Combination With Neurogenin3 Gene Therapy Reverses Established Overt Type 1 Diabetes in Female NOD Mice. Endocrinology. 2017 10 01; 158(10):3140-3151. PMID: 28977608; PMCID: PMC5659705.
      Citations: 3     Fields:    Translation:AnimalsCells
    17. Chen L, Liu C, Gao J, Xie Z, Chan LWC, Keating DJ, Yang Y, Sun J, Zhou F, Wei Y, Men X, Yang S. Inhibition of Miro1 disturbs mitophagy and pancreatic ?-cell function interfering insulin release via IRS-Akt-Foxo1 in diabetes. Oncotarget. 2017 Oct 31; 8(53):90693-90705. PMID: 29207597; PMCID: PMC5710878.
      Citations: 14     Fields:    
    18. Shi X, Chacko S, Li F, Li D, Burrin D, Chan L, Guan X. Acute activation of GLP-1-expressing neurons promotes glucose homeostasis and insulin sensitivity. Mol Metab. 2017 11; 6(11):1350-1359. PMID: 29107283; PMCID: PMC5681239.
      Citations: 14     Fields:    Translation:AnimalsCells
    19. Jois T, Chen W, Howard V, Harvey R, Youngs K, Thalmann C, Saha P, Chan L, Cowley MA, Sleeman MW. Deletion of hepatic carbohydrate response element binding protein (ChREBP) impairs glucose homeostasis and hepatic insulin sensitivity in mice. Mol Metab. 2017 11; 6(11):1381-1394. PMID: 29107286; PMCID: PMC5681238.
      Citations: 20     Fields:    Translation:AnimalsCells
    20. Tsai TH, Chen E, Li L, Saha P, Lee HJ, Huang LS, Shelness GS, Chan L, Chang BH. The constitutive lipid droplet protein PLIN2 regulates autophagy in liver. Autophagy. 2017 Jul 03; 13(7):1130-1144. PMID: 28548876; PMCID: PMC5529083.
      Citations: 45     Fields:    Translation:AnimalsCells
    21. Chan LW, Wang F, Meng F, Wang L, Wong SC, Au JS, Yang S, Cho WC. MiR-30 Family Potentially Targeting PI3K-SIAH2 Predicted Interaction Network Represents a Novel Putative Theranostic Panel in Non-small Cell Lung Cancer. Front Genet. 2017; 8:8. PMID: 28210267; PMCID: PMC5288379.
      Citations: 8     
    22. Chen E, Tsai TH, Li L, Saha P, Chan L, Chang BH. PLIN2 is a Key Regulator of the Unfolded Protein Response and Endoplasmic Reticulum Stress Resolution in Pancreatic ? Cells. Sci Rep. 2017 01 19; 7:40855. PMID: 28102311; PMCID: PMC5244387.
      Citations: 28     Fields:    Translation:AnimalsCells
    23. Yang Y, Bush SP, Wen X, Cao W, Chan L. Differential Gene Dosage Effects of Diabetes-Associated Gene GLIS3 in Pancreatic ? Cell Differentiation and Function. Endocrinology. 2017 01 01; 158(1):9-20. PMID: 27813676; PMCID: PMC5412984.
      Citations: 10     Fields:    Translation:AnimalsCells
    24. Weir MR, Pearson TC, Patel A, Peddi VR, Kalil R, Scandling J, Chan L, Baliga P, Melton L, Mulgaonkar S, Waid T, Schaefer H, Youssef N, Anandagoda L, McCollum D, Lawson S, Gordon R. Long-term Follow-up of Kidney Transplant Recipients in the Spare-the-Nephron-Trial. Transplantation. 2017 Jan; 101(1):157-165. PMID: 26950714.
      Citations:    
    25. Ito A, Hong C, Oka K, Salazar JV, Diehl C, Witztum JL, Bensinger SJ, Chan L, Tontonoz P, Diaz M, Castrillo A. Cholesterol Accumulation in CD11c+ Immune Cells Is a Causal and Targetable Factor in Autoimmune Disease. Immunity. 2016 12 20; 45(6):1311-1326. PMID: 28002731; PMCID: PMC5181791.
      Citations: 43     Fields:    Translation:AnimalsCells
    26. Meng F, Wang F, Wang L, Wong SC, Cho WC, Chan LW. MiR-30a-5p Overexpression May Overcome EGFR-Inhibitor Resistance through Regulating PI3K/AKT Signaling Pathway in Non-small Cell Lung Cancer Cell Lines. Front Genet. 2016; 7:197. PMID: 27895663; PMCID: PMC5108768.
      Citations: 36     
    27. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063; PMCID: PMC5374299.
      Citations: 4     Fields:    Translation:AnimalsCells
    28. Wang F, Meng F, Wang L, Wong SC, Cho WC, Chan LW. Associations of mRNA:microRNA for the Shared Downstream Molecules of EGFR and Alternative Tyrosine Kinase Receptors in Non-small Cell Lung Cancer. Front Genet. 2016; 7:173. PMID: 27790245; PMCID: PMC5061729.
      Citations: 7     
    29. Zhou X, Li R, Liu X, Wang L, Hui P, Chan L, Saha PK, Hu Z. ROCK1 reduces mitochondrial content and irisin production in muscle suppressing adipocyte browning and impairing insulin sensitivity. Sci Rep. 2016 07 14; 6:29669. PMID: 27411515; PMCID: PMC4944137.
      Citations: 15     Fields:    Translation:AnimalsCells
    30. Kyle SM, Saha PK, Brown HM, Chan LC, Justice MJ. MeCP2 co-ordinates liver lipid metabolism with the NCoR1/HDAC3 corepressor complex. Hum Mol Genet. 2016 07 15; 25(14):3029-3041. PMID: 27288453; PMCID: PMC5181597.
      Citations: 30     Fields:    Translation:Animals
    31. Kaushik AK, Shojaie A, Panzitt K, Sonavane R, Venghatakrishnan H, Manikkam M, Zaslavsky A, Putluri V, Vasu VT, Zhang Y, Khan AS, Lloyd S, Szafran AT, Dasgupta S, Bader DA, Stossi F, Li H, Samanta S, Cao X, Tsouko E, Huang S, Frigo DE, Chan L, Edwards DP, Kaipparettu BA, Mitsiades N, Weigel NL, Mancini M, McGuire SE, Mehra R, Ittmann MM, Chinnaiyan AM, Putluri N, Palapattu GS, Michailidis G, Sreekumar A. Inhibition of the hexosamine biosynthetic pathway promotes castration-resistant prostate cancer. Nat Commun. 2016 05 19; 7:11612. PMID: 27194471; PMCID: PMC4874037.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    32. Yang Y, Chan L. Monogenic Diabetes: What It Teaches Us on the Common Forms of Type 1 and Type 2 Diabetes. Endocr Rev. 2016 06; 37(3):190-222. PMID: 27035557; PMCID: PMC4890265.
      Citations: 41     Fields:    Translation:Humans
    33. Sae-Lee C, Moolsuwan K, Chan L, Poungvarin N. ChREBP Regulates Itself and Metabolic Genes Implicated in Lipid Accumulation in ?-Cell Line. PLoS One. 2016; 11(1):e0147411. PMID: 26808438; PMCID: PMC4725739.
      Citations: 14     Fields:    Translation:Cells
    34. Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T. Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation. Sci Rep. 2016 Jan 06; 6:18944. PMID: 26732653; PMCID: PMC4702170.
      Citations: 27     Fields:    Translation:AnimalsCells
    35. Urabe H, Terashima T, Kojima H, Chan L. Ablation of a small subpopulation of diabetes-specific bone marrow-derived cells in mice protects against diabetic neuropathy. Am J Physiol Endocrinol Metab. 2016 Feb 15; 310(4):E269-75. PMID: 26695138; PMCID: PMC4971812.
      Citations: 2     Fields:    Translation:AnimalsCells
    36. Du J, Rountree A, Cleghorn WM, Lindsay KJ, Sadilek M, Gu H, Djukovic D, Raftery D, Kanow M, Chan L, Tsang SH, Sweet IR, Hurley JB, Contreras L, Satr?stegui J. Phototransduction Influences Metabolic Flux and Nucleotide Metabolism in Mouse Retina. J Biol Chem. 2016 Feb 26; 291(9):4698-710. PMID: 26677218; PMCID: PMC4813492.
      Citations: 52     Fields:    Translation:AnimalsCells
    37. Son SH, Goo YH, Choi M, Saha PK, Oka K, Chan LC, Paul A. Enhanced atheroprotection and lesion remodelling by targeting the foam cell and increasing plasma cholesterol acceptors. Cardiovasc Res. 2016 Feb 01; 109(2):294-304. PMID: 26487692; PMCID: PMC4724936.
      Citations: 13     Fields:    Translation:AnimalsCells
    38. Sin TK, Tam BT, Yu AP, Yip SP, Yung BY, Chan LW, Wong CS, Rudd JA, Siu PM. Acute Treatment of Resveratrol Alleviates Doxorubicin-Induced Myotoxicity in Aged Skeletal Muscle Through SIRT1-Dependent Mechanisms. J Gerontol A Biol Sci Med Sci. 2016 06; 71(6):730-9. PMID: 26450947; PMCID: PMC4888387.
      Citations: 11     Fields:    Translation:AnimalsCells
    39. Zhu L, Xu P, Cao X, Yang Y, Hinton AO, Xia Y, Saito K, Yan X, Zou F, Ding H, Wang C, Yan C, Saha P, Khan SA, Zhao J, Fukuda M, Tong Q, Clegg DJ, Chan L, Xu Y. The ERa-PI3K Cascade in Proopiomelanocortin Progenitor Neurons Regulates Feeding and Glucose Balance in Female Mice. Endocrinology. 2015 Dec; 156(12):4474-91. PMID: 26375425; PMCID: PMC4655219.
      Citations: 23     Fields:    Translation:AnimalsCells
    40. Nuotio-Antar AM, Poungvarin N, Li M, Schupp M, Mohammad M, Gerard S, Zou F, Chan L. FABP4-Cre Mediated Expression of Constitutively Active ChREBP Protects Against Obesity, Fatty Liver, and Insulin Resistance. Endocrinology. 2015 Nov; 156(11):4020-32. PMID: 26248218; PMCID: PMC4606753.
      Citations: 20     Fields:    Translation:AnimalsCells
    41. Tam BT, Pei XM, Yung BY, Yip SP, Chan LW, Wong CS, Siu PM. Unacylated ghrelin restores insulin and autophagic signaling in skeletal muscle of diabetic mice. Pflugers Arch. 2015 Dec; 467(12):2555-69. PMID: 26228926.
      Citations: 7     Fields:    Translation:AnimalsCells
    42. Hartig SM, Bader DA, Abadie KV, Motamed M, Hamilton MP, Long W, York B, Mueller M, Wagner M, Trauner M, Chan L, Bajaj M, Moore DD, Mancini MA, McGuire SE. Ubc9 Impairs Activation of the Brown Fat Energy Metabolism Program in Human White Adipocytes. Mol Endocrinol. 2015 Sep; 29(9):1320-33. PMID: 26192107; PMCID: PMC4552434.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    43. Bissig-Choisat B, Wang L, Legras X, Saha PK, Chen L, Bell P, Pankowicz FP, Hill MC, Barzi M, Leyton CK, Leung HE, Kruse RL, Himes RW, Goss JA, Wilson JM, Chan L, Lagor WR, Bissig KD. Development and rescue of human familial hypercholesterolaemia in a xenograft mouse model. Nat Commun. 2015 Jun 17; 6:7339. PMID: 26081744; PMCID: PMC4557302.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    44. Willecke F, Yuan C, Oka K, Chan L, Hu Y, Barnhart S, Bornfeldt KE, Goldberg IJ, Fisher EA. Effects of High Fat Feeding and Diabetes on Regression of Atherosclerosis Induced by Low-Density Lipoprotein Receptor Gene Therapy in LDL Receptor-Deficient Mice. PLoS One. 2015; 10(6):e0128996. PMID: 26046657; PMCID: PMC4457481.
      Citations: 21     Fields:    Translation:AnimalsCells
    45. Sin TK, Yu AP, Yung BY, Yip SP, Chan LW, Wong CS, Rudd JA, Siu PM. Effects of long-term resveratrol-induced SIRT1 activation on insulin and apoptotic signalling in aged skeletal muscle. Acta Diabetol. 2015 Dec; 52(6):1063-75. PMID: 25959421.
      Citations: 12     Fields:    Translation:AnimalsCells
    46. Buras ED, Yang L, Saha P, Kim J, Mehta P, Yang Y, Hilsenbeck S, Kojima H, Chen W, Smith CW, Chan L. Proinsulin-producing, hyperglycemia-induced adipose tissue macrophages underlie insulin resistance in high fat-fed diabetic mice. FASEB J. 2015 Aug; 29(8):3537-48. PMID: 25953849; PMCID: PMC4511209.
      Citations: 6     Fields:    Translation:AnimalsCells
    47. Zhang L, Reyes R, Lee W, Chen CL, Chan L, Sujirakul T, Chang S, Tsang SH. Rapid resolution of retinoschisis with acetazolamide. Doc Ophthalmol. 2015 Aug; 131(1):63-70. PMID: 25796216; PMCID: PMC4504776.
      Citations: 4     Fields:    Translation:Humans
    48. Poungvarin N, Chang B, Imamura M, Chen J, Moolsuwan K, Sae-Lee C, Li W, Chan L. Genome-Wide Analysis of ChREBP Binding Sites on Male Mouse Liver and White Adipose Chromatin. Endocrinology. 2015 Jun; 156(6):1982-94. PMID: 25751637; PMCID: PMC4430618.
      Citations: 37     Fields:    Translation:AnimalsCells
    49. Urabe H, Terashima T, Lin F, Kojima H, Chan L. Bone marrow-derived TNF-a causes diabetic neuropathy in mice. Diabetologia. 2015 Feb; 58(2):402-10. PMID: 25399355; PMCID: PMC4289451.
      Citations: 11     Fields:    Translation:Animals
    50. Imamura M, Chang BH, Kohjima M, Li M, Chan L, Hwang B, Taegtmeyer H, Harris RA. MondoA deficiency enhances sprint performance in mice. Biochem J. 2014 Nov 15; 464(1):35-48. PMID: 25145386; PMCID: PMC4410994.
      Citations: 8     Fields:    Translation:Animals
    51. Yu AP, Pei XM, Sin TK, Yip SP, Yung BY, Chan LW, Wong CS, Siu PM. [D-Lys3]-GHRP-6 exhibits pro-autophagic effects on skeletal muscle. Mol Cell Endocrinol. 2015 Feb 05; 401:155-64. PMID: 25450862.
      Citations: 4     Fields:    Translation:AnimalsCells
    52. Li R, Lee J, Kim MS, Liu V, Moulik M, Li H, Yi Q, Xie A, Chen W, Yang L, Li Y, Tsai TH, Oka K, Chan L, Yechoor V. PD-L1-driven tolerance protects neurogenin3-induced islet neogenesis to reverse established type 1 diabetes in NOD mice. Diabetes. 2015 Feb; 64(2):529-40. PMID: 25332429; PMCID: PMC4303975.
      Citations: 11     Fields:    Translation:AnimalsCells
    53. Pei XM, Yung BY, Yip SP, Chan LW, Wong CS, Ying M, Siu PM. Protective effects of desacyl ghrelin on diabetic cardiomyopathy. Acta Diabetol. 2015 Apr; 52(2):293-306. PMID: 25192951.
      Citations: 18     Fields:    Translation:HumansAnimals
    54. Chen W, Zhou H, Saha P, Li L, Chan L. Molecular mechanisms underlying fasting modulated liver insulin sensitivity and metabolism in male lipodystrophic Bscl2/Seipin-deficient mice. Endocrinology. 2014 Nov; 155(11):4215-25. PMID: 25093462; PMCID: PMC4197977.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    55. Yuan C, Lai CW, Chan LW, Chow M, Law HK, Ying M. The effect of diabetes self-management education on body weight, glycemic control, and other metabolic markers in patients with type 2 diabetes mellitus. J Diabetes Res. 2014; 2014:789761. PMID: 25136645; PMCID: PMC4127232.
      Citations: 25     Fields:    Translation:Humans
    56. Tsang SH, Chan L, Tsai YT, Wu WH, Hsu CW, Yang J, Tosi J, Wert KJ, Davis RJ, Mahajan VB. Silencing of tuberin enhances photoreceptor survival and function in a preclinical model of retinitis pigmentosa (an american ophthalmological society thesis). Trans Am Ophthalmol Soc. 2014 Jul; 112:103-15. PMID: 25646031; PMCID: PMC4311672.
      Citations: 12     Fields:    Translation:AnimalsCells
    57. Terashima T, Kojima H, Urabe H, Yamakawa I, Ogawa N, Kawai H, Chan L, Maegawa H. Stem cell factor-activated bone marrow ameliorates amyotrophic lateral sclerosis by promoting protective microglial migration. J Neurosci Res. 2014 Jul; 92(7):856-69. PMID: 24936617; PMCID: PMC4061499.
      Citations: 4     Fields:    Translation:AnimalsCells
    58. Li Y, Wu WH, Hsu CW, Nguyen HV, Tsai YT, Chan L, Nagasaki T, Maumenee IH, Yannuzzi LA, Hoang QV, Hua H, Egli D, Tsang SH. Gene therapy in patient-specific stem cell lines and a preclinical model of retinitis pigmentosa with membrane frizzled-related protein defects. Mol Ther. 2014 Sep; 22(9):1688-97. PMID: 24895994; PMCID: PMC4435479.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    59. Zhao L, Nakae Y, Qin H, Ito T, Kimura T, Kojima H, Chan L, Komatsu N. Polyglycerol-functionalized nanodiamond as a platform for gene delivery: Derivatization, characterization, and hybridization with DNA. Beilstein J Org Chem. 2014; 10:707-13. PMID: 24778723; PMCID: PMC3999746.
      Citations: 7     
    60. Ogawa N, Kawai H, Terashima T, Kojima H, Oka K, Chan L, Maegawa H. Gene therapy for neuropathic pain by silencing of TNF-a expression with lentiviral vectors targeting the dorsal root ganglion in mice. PLoS One. 2014; 9(3):e92073. PMID: 24642694; PMCID: PMC3958473.
      Citations: 27     Fields:    Translation:AnimalsCells
    61. Sin TK, Yu AP, Yung BY, Yip SP, Chan LW, Wong CS, Ying M, Rudd JA, Siu PM. Modulating effect of SIRT1 activation induced by resveratrol on Foxo1-associated apoptotic signalling in senescent heart. J Physiol. 2014 Jun 15; 592(12):2535-48. PMID: 24639483; PMCID: PMC4080936.
      Citations: 33     Fields:    Translation:AnimalsCells
    62. Katagi M, Terashima T, Okano J, Urabe H, Nakae Y, Ogawa N, Udagawa J, Maegawa H, Matsumura K, Chan L, Kojima H. Hyperglycemia induces abnormal gene expression in hematopoietic stem cells and their progeny in diabetic neuropathy. FEBS Lett. 2014 Mar 18; 588(6):1080-6. PMID: 24583009; PMCID: PMC4004028.
      Citations: 7     Fields:    Translation:AnimalsCells
    63. Kojima H, Kim J, Chan L. Emerging roles of hematopoietic cells in the pathobiology of diabetic complications. Trends Endocrinol Metab. 2014 Apr; 25(4):178-87. PMID: 24507996; PMCID: PMC3975817.
      Citations: 23     Fields:    Translation:HumansAnimals
    64. Yang J, Li Y, Chan L, Tsai YT, Wu WH, Nguyen HV, Hsu CW, Li X, Brown LM, Egli D, Sparrow JR, Tsang SH. Validation of genome-wide association study (GWAS)-identified disease risk alleles with patient-specific stem cell lines. Hum Mol Genet. 2014 Jul 01; 23(13):3445-55. PMID: 24497574; PMCID: PMC4049304.
      Citations: 44     Fields:    Translation:HumansCells
    65. Chan CM, Au TC, Chan AT, Ma BB, Tsui NB, Ng SS, Hui EP, Chan LW, Ho WS, Yung BY, Wong SC. Advanced technologies for studying circulating tumor cells at the protein level. Expert Rev Proteomics. 2013 Dec; 10(6):579-89. PMID: 24206230.
      Citations: 2     Fields:    Translation:HumansCells
    66. Dong S, Jia C, Zhang S, Fan G, Li Y, Shan P, Sun L, Xiao W, Li L, Zheng Y, Liu J, Wei H, Hu C, Zhang W, Chin YE, Zhai Q, Li Q, Liu J, Jia F, Mo Q, Edwards DP, Huang S, Chan L, O'Malley BW, Li X, Wang C. The REG? proteasome regulates hepatic lipid metabolism through inhibition of autophagy. Cell Metab. 2013 Sep 03; 18(3):380-91. PMID: 24011073; PMCID: PMC3813599.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    67. Kohjima M, Tsai TH, Tackett BC, Thevananther S, Li L, Chang BH, Chan L. Delayed liver regeneration after partial hepatectomy in adipose differentiation related protein-null mice. J Hepatol. 2013 Dec; 59(6):1246-54. PMID: 23928401; PMCID: PMC4001732.
      Citations: 13     Fields:    Translation:AnimalsCells
    68. Yang J, Lin SC, Chen G, He L, Hu Z, Chan L, Trial J, Entman ML, Wang Y. Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis. J Am Soc Nephrol. 2013 Oct; 24(10):1644-59. PMID: 23833260; PMCID: PMC3785282.
      Citations: 55     Fields:    Translation:AnimalsCells
    69. Shi X, Zhou F, Li X, Chang B, Li D, Wang Y, Tong Q, Xu Y, Fukuda M, Zhao JJ, Li D, Burrin DG, Chan L, Guan X. Central GLP-2 enhances hepatic insulin sensitivity via activating PI3K signaling in POMC neurons. Cell Metab. 2013 Jul 02; 18(1):86-98. PMID: 23823479; PMCID: PMC3752162.
      Citations: 37     Fields:    Translation:AnimalsCells
    70. Piccio L, Cantoni C, Henderson JG, Hawiger D, Ramsbottom M, Mikesell R, Ryu J, Hsieh CS, Cremasco V, Haynes W, Dong LQ, Chan L, Galimberti D, Cross AH. Lack of adiponectin leads to increased lymphocyte activation and increased disease severity in a mouse model of multiple sclerosis. Eur J Immunol. 2013 Aug; 43(8):2089-100. PMID: 23640763; PMCID: PMC3901539.
      Citations: 35     Fields:    Translation:AnimalsCells
    71. Merched AJ, Chan L. Nutrigenetics and nutrigenomics of atherosclerosis. Curr Atheroscler Rep. 2013 Jun; 15(6):328. PMID: 23605288; PMCID: PMC4003879.
      Citations: 9     Fields:    Translation:Humans
    72. Dahlhoff M, Camera E, Picardo M, Zouboulis CC, Chan L, Chang BH, Schneider MR. PLIN2, the major perilipin regulated during sebocyte differentiation, controls sebaceous lipid accumulation in vitro and sebaceous gland size in vivo. Biochim Biophys Acta. 2013 Oct; 1830(10):4642-9. PMID: 23688400; PMCID: PMC3998206.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    73. Settembre C, De Cegli R, Mansueto G, Saha PK, Vetrini F, Visvikis O, Huynh T, Carissimo A, Palmer D, Wollenberg AC, Di Bernardo D, Chan L, Irazoqui JE, Ballabio A, Klisch TJ. TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol. 2013 Jun; 15(6):647-58. PMID: 23604321; PMCID: PMC3699877.
      Citations: 449     Fields:    Translation:HumansAnimalsCells
    74. Chen W, Chang B, Wu X, Li L, Sleeman M, Chan L. Inactivation of Plin4 downregulates Plin5 and reduces cardiac lipid accumulation in mice. Am J Physiol Endocrinol Metab. 2013 Apr 01; 304(7):E770-9. PMID: 23423172; PMCID: PMC3625749.
      Citations: 36     Fields:    Translation:AnimalsCells
    75. Chen W, Xie A, Chan L. Mechanistic basis of immunotherapies for type 1 diabetes mellitus. Transl Res. 2013 Apr; 161(4):217-29. PMID: 23348026; PMCID: PMC3602320.
      Citations: 11     Fields:    Translation:HumansCells
    76. Jin X, Chen J, Hu Z, Chan L, Wang Y. Genetic deficiency of adiponectin protects against acute kidney injury. Kidney Int. 2013 Apr; 83(4):604-14. PMID: 23302722; PMCID: PMC3612389.
      Citations: 42     Fields:    Translation:AnimalsCells
    77. Urabe H, Kojima H, Chan L, Terashima T, Ogawa N, Katagi M, Fujino K, Kumagai A, Kawai H, Asakawa A, Inui A, Yasuda H, Eguchi Y, Oka K, Maegawa H, Kashiwagi A, Kimura H. Haematopoietic cells produce BDNF and regulate appetite upon migration to the hypothalamus. Nat Commun. 2013; 4:1526. PMID: 23443554; PMCID: PMC3640364.
      Citations: 8     Fields:    Translation:AnimalsCells
    78. Yang Y, Chang BH, Chan L. Sustained expression of the transcription factor GLIS3 is required for normal beta cell function in adults. EMBO Mol Med. 2013 01; 5(1):92-104. PMID: 23197416; PMCID: PMC3569656.
      Citations: 36     Fields:    Translation:AnimalsCells
    79. Takemura Y, Imai S, Kojima H, Katagi M, Yamakawa I, Kasahara T, Urabe H, Terashima T, Yasuda H, Chan L, Kimura H, Matsusue Y. Brain-derived neurotrophic factor from bone marrow-derived cells promotes post-injury repair of peripheral nerve. PLoS One. 2012; 7(9):e44592. PMID: 23028564; PMCID: PMC3446933.
      Citations: 13     Fields:    Translation:AnimalsCells
    80. Shi X, Li X, Chang B, Wang Y, Li D, Chan L, Guan X. GLP-2 receptor in POMC neurons suppresses feeding behavior and gastric motility. Am J Physiol Endocrinol Metab. 2012 Oct 01; 303(7):E853-64. PMID: 22829581; PMCID: PMC3469617.
      Citations: 20     Fields:    Translation:AnimalsCells
    81. Lacaria M, Saha P, Potocki L, Bi W, Yan J, Girirajan S, Burns B, Elsea S, Walz K, Chan L, Lupski JR, Gu W. A duplication CNV that conveys traits reciprocal to metabolic syndrome and protects against diet-induced obesity in mice and men. PLoS Genet. 2012; 8(5):e1002713. PMID: 22654670; PMCID: PMC3359973.
      Citations: 28     Fields:    Translation:HumansAnimals
    82. Chen W, Chang B, Saha P, Hartig SM, Li L, Reddy VT, Yang Y, Yechoor V, Mancini MA, Chan L. Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol. 2012 Mar; 32(6):1099-111. PMID: 22269949; PMCID: PMC3295006.
      Citations: 70     Fields:    Translation:AnimalsCells
    83. Speakman JR, Arch JR, Auwerx J, Chan L, Eckel RH, Farese RV, Galgani JE, Hambly C, Herman MA, Horvath TL, Kahn BB, Kozma SC, Maratos-Flier E, Pfluger PT, Plum L, Reitman ML, Rahmouni K, Shulman GI, Thomas G, Kahn CR, Ravussin E, Tsch?p MH, Br?ning JC, M?ller TD, M?nzberg H. A guide to analysis of mouse energy metabolism. Nat Methods. 2011 Dec 28; 9(1):57-63. PMID: 22205519; PMCID: PMC3654855.
      Citations: 366     Fields:    Translation:Animals
    84. Chan L, Terashima T, Urabe H, Lin F, Kojima H. Pathogenesis of diabetic neuropathy: bad to the bone. Ann N Y Acad Sci. 2011 Dec; 1240:70-6. PMID: 22172042; PMCID: PMC3636709.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    85. Barnhart KF, Christianson DR, Hanley PW, Driessen WH, Bernacky BJ, Baze WB, Wen S, Tian M, Ma J, Kolonin MG, Saha PK, Do KA, Hulvat JF, Gelovani JG, Chan L, Arap W, Pasqualini R. A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med. 2011 Nov 09; 3(108):108ra112. PMID: 22072637; PMCID: PMC3666164.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    86. Terashima T, Kojima H, Chan L. Bone marrow expression of poly(ADP-ribose) polymerase underlies diabetic neuropathy via hematopoietic-neuronal cell fusion. FASEB J. 2012 Jan; 26(1):295-308. PMID: 21978940; PMCID: PMC3250244.
      Citations: 12     Fields:    Translation:AnimalsCells
    87. Li R, Chao H, Ko KW, Cormier S, Dieker C, Nour EA, Wang S, Chan L, Oka K. Gene Therapy Targeting LDL Cholesterol but not HDL Cholesterol Induces Regression of Advanced Atherosclerosis in a Mouse Model of Familial Hypercholesterolemia. J Genet Syndr Gene Ther. 2011 Sep 28; 2:106. PMID: 23106034; PMCID: PMC3480198.
      Citations: 13     
    88. Russell TD, Schaack J, Orlicky DJ, Palmer C, Chang BH, Chan L, McManaman JL. Adipophilin regulates maturation of cytoplasmic lipid droplets and alveolae in differentiating mammary glands. J Cell Sci. 2011 Oct 01; 124(Pt 19):3247-53. PMID: 21878492; PMCID: PMC3178452.
      Citations: 29     Fields:    Translation:AnimalsCells
    89. Yamakawa I, Kojima H, Terashima T, Katagi M, Oi J, Urabe H, Sanada M, Kawai H, Chan L, Yasuda H, Maegawa H, Kimura H. Inactivation of TNF-a ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab. 2011 Nov; 301(5):E844-52. PMID: 21810933; PMCID: PMC3213998.
      Citations: 51     Fields:    Translation:Animals
    90. Li R, Paul A, Ko KW, Sheldon M, Rich BE, Terashima T, Dieker C, Cormier S, Li L, Nour EA, Chan L, Oka K. Interleukin-7 induces recruitment of monocytes/macrophages to endothelium. Eur Heart J. 2012 Dec; 33(24):3114-23. PMID: 21804111; PMCID: PMC3598429.
      Citations: 22     Fields:    Translation:AnimalsCells
    91. Cheng NH, Zhang W, Chen WQ, Jin J, Cui X, Butte NF, Chan L, Hirschi KD. A mammalian monothiol glutaredoxin, Grx3, is critical for cell cycle progression during embryogenesis. FEBS J. 2011 Jul; 278(14):2525-2539. PMID: 21575136; PMCID: PMC4038268.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    92. Li Y, Kojima H, Fujino K, Matsumura K, Katagi M, Urabe H, Chan L, Eguchi Y, Zhao L, Kimura H. Homing of the bone marrow-derived interstitial cells of Cajal is decreased in diabetic mouse intestine. J Gastroenterol Hepatol. 2011 Jun; 26(6):1072-8. PMID: 21265880; PMCID: PMC3321643.
      Citations: 5     Fields:    Translation:AnimalsCells
    93. Merched AJ, Serhan CN, Chan L. Nutrigenetic disruption of inflammation-resolution homeostasis and atherogenesis. J Nutrigenet Nutrigenomics. 2011; 4(1):12-24. PMID: 21474962; PMCID: PMC3080581.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    94. Chopra AR, Kommagani R, Saha P, Louet JF, Salazar C, Song J, Jeong J, Finegold M, Viollet B, DeMayo F, Chan L, Moore DD, O'Malley BW. Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab. 2011 Jan 05; 13(1):35-43. PMID: 21195347; PMCID: PMC3072049.
      Citations: 45     Fields:    Translation:HumansAnimalsCells
    95. Shi X, Li X, Wang Y, Zhang K, Zhou F, Chan L, Li D, Guan X. Glucagon-like peptide-2-stimulated protein synthesis through the PI 3-kinase-dependent Akt-mTOR signaling pathway. Am J Physiol Endocrinol Metab. 2011 Mar; 300(3):E554-63. PMID: 21177288; PMCID: PMC3279303.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    96. Saha PK, Reddy VT, Konopleva M, Andreeff M, Chan L. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice. J Biol Chem. 2010 Dec 24; 285(52):40581-92. PMID: 20956520; PMCID: PMC3003357.
      Citations: 48     Fields:    Translation:AnimalsCells
    97. Sharma R, Buras E, Terashima T, Serrano F, Massaad CA, Hu L, Bitner B, Inoue T, Chan L, Pautler RG. Hyperglycemia induces oxidative stress and impairs axonal transport rates in mice. PLoS One. 2010 Oct 18; 5(10):e13463. PMID: 20976160; PMCID: PMC2956689.
      Citations: 35     Fields:    Translation:AnimalsCells
    98. Chen W, Chang B, Li L, Chan L. Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. Hepatology. 2010 Sep; 52(3):1134-42. PMID: 20648554; PMCID: PMC2932863.
      Citations: 105     Fields:    Translation:Animals
    99. Zhou M, Xu A, Lam KS, Tam PK, Che CM, Chan L, Lee IK, Wu D, Wang Y. Rosiglitazone promotes fatty acyl CoA accumulation and excessive glycogen storage in livers of mice without adiponectin. J Hepatol. 2010 Dec; 53(6):1108-16. PMID: 20828853.
      Citations: 13     Fields:    Translation:AnimalsCells
    100. Wagner RT, Lewis J, Cooney A, Chan L. Stem cell approaches for the treatment of type 1 diabetes mellitus. Transl Res. 2010 Sep; 156(3):169-79. PMID: 20801414; PMCID: PMC2935591.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    101. Kasahara T, Imai S, Kojima H, Katagi M, Kimura H, Chan L, Matsusue Y. Malfunction of bone marrow-derived osteoclasts and the delay of bone fracture healing in diabetic mice. Bone. 2010 Sep; 47(3):617-25. PMID: 20601287; PMCID: PMC2926189.
      Citations: 25     Fields:    Translation:AnimalsCells
    102. Chang BH, Li L, Saha P, Chan L. Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice. J Lipid Res. 2010 Aug; 51(8):2132-42. PMID: 20424269; PMCID: PMC2903828.
      Citations: 45     Fields:    Translation:AnimalsCells
    103. Li MV, Chen W, Harmancey RN, Nuotio-Antar AM, Imamura M, Saha P, Taegtmeyer H, Chan L. Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun. 2010 May 07; 395(3):395-400. PMID: 20382127; PMCID: PMC2874883.
      Citations: 49     Fields:    Translation:HumansAnimalsCells
    104. Yechoor V, Chan L. Minireview: beta-cell replacement therapy for diabetes in the 21st century: manipulation of cell fate by directed differentiation. Mol Endocrinol. 2010 Aug; 24(8):1501-11. PMID: 20219891; PMCID: PMC2940465.
      Citations: 13     Fields:    Translation:HumansCells
    105. Kohjima M, Sun Y, Chan L. Increased food intake leads to obesity and insulin resistance in the tg2576 Alzheimer's disease mouse model. Endocrinology. 2010 Apr; 151(4):1532-40. PMID: 20176720; PMCID: PMC2850232.
      Citations: 39     Fields:    Translation:Animals
    106. Wang Y, Li X, Guo Y, Chan L, Guan X. alpha-Lipoic acid increases energy expenditure by enhancing adenosine monophosphate-activated protein kinase-peroxisome proliferator-activated receptor-gamma coactivator-1alpha signaling in the skeletal muscle of aged mice. Metabolism. 2010 Jul; 59(7):967-76. PMID: 20015518; PMCID: PMC2882509.
      Citations: 26     Fields:    Translation:AnimalsCells
    107. Tao L, Wang Y, Gao E, Zhang H, Yuan Y, Lau WB, Chan L, Koch WJ, Ma XL. Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction. Circ Res. 2010 Feb 05; 106(2):409-17. PMID: 19940263; PMCID: PMC2818803.
      Citations: 37     Fields:    Translation:HumansAnimalsCells
    108. Dong B, Saha PK, Huang W, Chen W, Abu-Elheiga LA, Wakil SJ, Stevens RD, Ilkayeva O, Newgard CB, Chan L, Moore DD. Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A. 2009 Nov 03; 106(44):18831-6. PMID: 19850873; PMCID: PMC2773998.
      Citations: 116     Fields:    Translation:AnimalsCells
    109. Merched A, Tollefson K, Chan L. Beta2 integrins modulate the initiation and progression of atherosclerosis in low-density lipoprotein receptor knockout mice. Cardiovasc Res. 2010 Mar 01; 85(4):853-63. PMID: 19843511; PMCID: PMC2819833.
      Citations: 10     Fields:    Translation:AnimalsCells
    110. Yechoor V, Liu V, Paul A, Lee J, Buras E, Ozer K, Samson S, Chan L. Gene therapy with neurogenin 3 and betacellulin reverses major metabolic problems in insulin-deficient diabetic mice. Endocrinology. 2009 Nov; 150(11):4863-73. PMID: 19819964; PMCID: PMC2775983.
      Citations: 19     Fields:    Translation:HumansAnimals
    111. Helft J, Tiwari S, Vargas P, Chang BH, Chan L, Campisi L, Lauvau G, Hugues S, Kumar P, Kamphorst AO, Dumenil AM, Nussenzweig M, MacMicking JD, Amigorena S, Guermonprez P, Bougn?res L. A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity. 2009 Aug 21; 31(2):232-44. PMID: 19699172; PMCID: PMC2803012.
      Citations: 71     Fields:    Translation:AnimalsCells
    112. Chen W, Yechoor VK, Chang BH, Li MV, March KL, Chan L. The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation. Endocrinology. 2009 Oct; 150(10):4552-61. PMID: 19574402; PMCID: PMC2754678.
      Citations: 64     Fields:    Translation:HumansAnimalsCells
    113. Terashima T, Oka K, Kritz AB, Kojima H, Baker AH, Chan L. DRG-targeted helper-dependent adenoviruses mediate selective gene delivery for therapeutic rescue of sensory neuronopathies in mice. J Clin Invest. 2009 Jul; 119(7):2100-112. PMID: 19603551; PMCID: PMC2701884.
      Citations: 20     Fields:    Translation:AnimalsCells
    114. Ko KW, Corry DB, Brayton CF, Paul A, Chan L. Extravascular inflammation does not increase atherosclerosis in apoE-deficient mice. Biochem Biophys Res Commun. 2009 Jun 19; 384(1):93-9. PMID: 19393222; PMCID: PMC2739567.
      Citations: 4     Fields:    Translation:Animals
    115. Wilhelm AJ, Zabalawi M, Grayson JM, Weant AE, Major AS, Owen J, Bharadwaj M, Walzem R, Chan L, Oka K, Thomas MJ, Sorci-Thomas MG. Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol. 2009 Jun; 29(6):843-9. PMID: 19286630; PMCID: PMC2761013.
      Citations: 62     Fields:    Translation:AnimalsCells
    116. Yang Y, Chang BH, Samson SL, Li MV, Chan L. The Kr?ppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res. 2009 May; 37(8):2529-38. PMID: 19264802; PMCID: PMC2677877.
      Citations: 46     Fields:    Translation:AnimalsCells
    117. Yechoor V, Liu V, Espiritu C, Paul A, Oka K, Kojima H, Chan L. Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell. 2009 Mar; 16(3):358-73. PMID: 19289082; PMCID: PMC2676438.
      Citations: 86     Fields:    Translation:AnimalsCells
    118. Li L, Xie X, Qin J, Jeha GS, Saha PK, Yan J, Haueter CM, Chan L, Tsai SY, Tsai MJ. The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab. 2009 Jan 07; 9(1):77-87. PMID: 19117548; PMCID: PMC2630393.
      Citations: 61     Fields:    Translation:AnimalsCells
    119. Paul A, Chan L, Bickel PE. The PAT family of lipid droplet proteins in heart and vascular cells. Curr Hypertens Rep. 2008 Dec; 10(6):461-6. PMID: 18959832; PMCID: PMC2892414.
      Citations: 23     Fields:    Translation:HumansCells
    120. Lee J, Saha PK, Yang QH, Lee S, Park JY, Suh Y, Lee SK, Chan L, Roeder RG, Lee JW. Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19229-34. PMID: 19047629; PMCID: PMC2614744.
      Citations: 100     Fields:    Translation:AnimalsCells
    121. Chopra AR, Louet JF, Saha P, An J, Demayo F, Xu J, York B, Karpen S, Finegold M, Moore D, Chan L, Newgard CB, O'Malley BW. Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science. 2008 Nov 28; 322(5906):1395-9. PMID: 19039140; PMCID: PMC2668604.
      Citations: 96     Fields:    Translation:AnimalsCells
    122. Cao Y, Tao L, Yuan Y, Jiao X, Lau WB, Wang Y, Christopher T, Lopez B, Chan L, Goldstein B, Ma XL. Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol. 2009 Mar; 46(3):413-9. PMID: 19027750; PMCID: PMC2671019.
      Citations: 47     Fields:    Translation:Animals
    123. Zhou M, Xu A, Tam PK, Lam KS, Chan L, Hoo RL, Liu J, Chow KH, Wang Y. Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology. 2008 Oct; 48(4):1087-96. PMID: 18698578; PMCID: PMC2597507.
      Citations: 34     Fields:    Translation:AnimalsCells
    124. Samson SL, Gonzalez EV, Yechoor V, Bajaj M, Oka K, Chan L. Gene therapy for diabetes: metabolic effects of helper-dependent adenoviral exendin 4 expression in a diet-induced obesity mouse model. Mol Ther. 2008 11; 16(11):1805-12. PMID: 18781141; PMCID: PMC2582376.
      Citations: 18     Fields:    Translation:AnimalsCells
    125. Teoh H, Quan A, Bang KW, Wang G, Lovren F, Vu V, Haitsma JJ, Szmitko PE, Al-Omran M, Wang CH, Gupta M, Peterson MD, Zhang H, Chan L, Freedman J, Sweeney G, Verma S. Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab. 2008 Sep; 295(3):E658-64. PMID: 18628355; PMCID: PMC2536730.
      Citations: 30     Fields:    Translation:Animals
    126. Nie J, Chang B, Traktuev DO, Sun J, March K, Chan L, Sage EH, Pasqualini R, Arap W, Kolonin MG. IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells. Stem Cells. 2008 Oct; 26(10):2735-45. PMID: 18583538; PMCID: PMC4066418.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    127. Merched AJ, Ko K, Gotlinger KH, Serhan CN, Chan L. Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J. 2008 Oct; 22(10):3595-606. PMID: 18559988; PMCID: PMC2537438.
      Citations: 185     Fields:    Translation:HumansAnimalsCells
    128. Liao W, Strube RW, Milne RW, Chen SY, Chan L. Cloning of apoB intrabodies: specific knockdown of apoB in HepG2 cells. Biochem Biophys Res Commun. 2008 Aug 22; 373(2):235-40. PMID: 18558087; PMCID: PMC2496960.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    129. Paul A, Chang BH, Li L, Yechoor VK, Chan L. Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res. 2008 Jun 20; 102(12):1492-501. PMID: 18483409; PMCID: PMC2773502.
      Citations: 69     Fields:    Translation:AnimalsCells
    130. Sharma K, Ramachandrarao S, Qiu G, Usui HK, Zhu Y, Dunn SR, Ouedraogo R, Hough K, McCue P, Chan L, Falkner B, Goldstein BJ. Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest. 2008 May; 118(5):1645-56. PMID: 18431508; PMCID: PMC2323186.
      Citations: 259     Fields:    Translation:HumansAnimalsCells
    131. Pini M, Gove ME, Sennello JA, van Baal JW, Chan L, Fantuzzi G. Role and regulation of adipokines during zymosan-induced peritoneal inflammation in mice. Endocrinology. 2008 Aug; 149(8):4080-5. PMID: 18450950; PMCID: PMC2488230.
      Citations: 14     Fields:    Translation:Animals
    132. Li MV, Chen W, Poungvarin N, Imamura M, Chan L. Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3. Mol Endocrinol. 2008 Jul; 22(7):1658-72. PMID: 18436566; PMCID: PMC2453601.
      Citations: 23     Fields:    Translation:AnimalsCells
    133. Paul A, Yechoor V, Raja R, Li L, Chan L. Microarray gene profiling of laser-captured cells: a new tool to study atherosclerosis in mice. Atherosclerosis. 2008 Oct; 200(2):257-63. PMID: 18289551; PMCID: PMC2613781.
      Citations: 5     Fields:    Translation:AnimalsCells
    134. Johansson F, Kramer F, Barnhart S, Kanter JE, Vaisar T, Merrill RD, Geng L, Oka K, Chan L, Chait A, Heinecke JW, Bornfeldt KE. Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci U S A. 2008 Feb 12; 105(6):2082-7. PMID: 18252823; PMCID: PMC2538884.
      Citations: 53     Fields:    Translation:AnimalsCells
    135. Oi J, Terashima T, Kojima H, Fujimiya M, Maeda K, Arai R, Chan L, Yasuda H, Kashiwagi A, Kimura H. Isolation of specific peptides that home to dorsal root ganglion neurons in mice. Neurosci Lett. 2008 Apr 04; 434(3):266-72. PMID: 18329804; PMCID: PMC2348187.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    136. Hoo RL, Chow WS, Yau MH, Xu A, Tso AW, Tse HF, Fong CH, Tam S, Chan L, Lam KS. Adiponectin mediates the suppressive effect of rosiglitazone on plasminogen activator inhibitor-1 production. Arterioscler Thromb Vasc Biol. 2007 Dec; 27(12):2777-82. PMID: 17932317.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    137. Russell TD, Palmer CA, Orlicky DJ, Bales ES, Chang BH, Chan L, McManaman JL. Mammary glands of adipophilin-null mice produce an amino-terminally truncated form of adipophilin that mediates milk lipid droplet formation and secretion. J Lipid Res. 2008 Jan; 49(1):206-16. PMID: 17921437.
      Citations: 33     Fields:    Translation:Animals
    138. Huang J, Iqbal J, Saha PK, Liu J, Chan L, Hussain MM, Moore DD, Wang L. Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology. 2007 Jul; 46(1):147-57. PMID: 17526026.
      Citations: 79     Fields:    Translation:AnimalsCells
    139. Matsumura K, Chang BH, Fujimiya M, Chen W, Kulkarni RN, Eguchi Y, Kimura H, Kojima H, Chan L. Aquaporin 7 is a beta-cell protein and regulator of intraislet glycerol content and glycerol kinase activity, beta-cell mass, and insulin production and secretion. Mol Cell Biol. 2007 Sep; 27(17):6026-37. PMID: 17576812; PMCID: PMC1952143.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    140. Ouedraogo R, Gong Y, Berzins B, Wu X, Mahadev K, Hough K, Chan L, Goldstein BJ, Scalia R. Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest. 2007 Jun; 117(6):1718-26. PMID: 17549259; PMCID: PMC1878515.
      Citations: 102     Fields:    Translation:AnimalsCells
    141. Tao L, Gao E, Jiao X, Yuan Y, Li S, Christopher TA, Lopez BL, Koch W, Chan L, Goldstein BJ, Ma XL. Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation. 2007 Mar 20; 115(11):1408-16. PMID: 17339545.
      Citations: 155     Fields:    Translation:AnimalsCells
    142. Fujimiya M, Kojima H, Ichinose M, Arai R, Kimura H, Kashiwagi A, Chan L. Fusion of proinsulin-producing bone marrow-derived cells with hepatocytes in diabetes. Proc Natl Acad Sci U S A. 2007 Mar 06; 104(10):4030-5. PMID: 17360472; PMCID: PMC1820703.
      Citations: 15     Fields:    Translation:AnimalsCells
    143. Wu H, Ghosh S, Perrard XD, Feng L, Garcia GE, Perrard JL, Sweeney JF, Peterson LE, Chan L, Smith CW, Ballantyne CM. T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation. 2007 Feb 27; 115(8):1029-38. PMID: 17296858.
      Citations: 311     Fields:    Translation:HumansAnimalsCells
    144. Chang BH, Chan L. Regulation of Triglyceride Metabolism. III. Emerging role of lipid droplet protein ADFP in health and disease. Am J Physiol Gastrointest Liver Physiol. 2007 Jun; 292(6):G1465-8. PMID: 17194897.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    145. Fayad R, Pini M, Sennello JA, Cabay RJ, Chan L, Xu A, Fantuzzi G. Adiponectin deficiency protects mice from chemically induced colonic inflammation. Gastroenterology. 2007 Feb; 132(2):601-14. PMID: 17258715.
      Citations: 55     Fields:    Translation:Animals
    146. Liao W, Li X, Mancini M, Chan L. Proteasome inhibition induces differential heat shock protein response but not unfolded protein response in HepG2 cells. J Cell Biochem. 2006 Nov 01; 99(4):1085-95. PMID: 16767695.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    147. Sztalryd C, Bell M, Lu X, Mertz P, Hickenbottom S, Chang BH, Chan L, Kimmel AR, Londos C. Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. J Biol Chem. 2006 Nov 10; 281(45):34341-8. PMID: 16968708.
      Citations: 57     Fields:    Translation:AnimalsCells
    148. Kojima H, Fujimiya M, Terashima T, Kimura H, Chan L. Extrapancreatic proinsulin/insulin-expressing cells in diabetes mellitus: is history repeating itself? Endocr J. 2006 Dec; 53(6):715-22. PMID: 16960402.
      Citations: 9     Fields:    Translation:HumansAnimals
    149. Liao D, Tan H, Hui R, Li Z, Jiang X, Gaubatz J, Yang F, Durante W, Chan L, Schafer AI, Pownall HJ, Yang X, Wang H. Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res. 2006 Sep 15; 99(6):598-606. PMID: 16931800; PMCID: PMC4400841.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    150. Pini M, Sennello JA, Chan L, Fantuzzi G. Adiponectin deficiency does not affect the inflammatory response to endotoxin or concanavalin a in mice. Endocrinology. 2006 Nov; 147(11):5019-22. PMID: 16901963.
      Citations: 8     Fields:    Translation:Animals
    151. MacDougall ED, Kramer F, Polinsky P, Barnhart S, Askari B, Johansson F, Varon R, Rosenfeld ME, Oka K, Chan L, Schwartz SM, Bornfeldt KE. Aggressive very low-density lipoprotein (VLDL) and LDL lowering by gene transfer of the VLDL receptor combined with a low-fat diet regimen induces regression and reduces macrophage content in advanced atherosclerotic lesions in LDL receptor-deficient mice. Am J Pathol. 2006 Jun; 168(6):2064-73. PMID: 16723719; PMCID: PMC1606621.
      Citations: 20     Fields:    Translation:AnimalsCells
    152. Johnson JL, Baker AH, Oka K, Chan L, Newby AC, Jackson CL, George SJ. Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis. Circulation. 2006 May 23; 113(20):2435-44. PMID: 16702468.
      Citations: 49     Fields:    Translation:AnimalsCells
    153. Li MV, Chang B, Imamura M, Poungvarin N, Chan L. Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes. 2006 May; 55(5):1179-89. PMID: 16644671.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    154. Sun Y, Asnicar M, Saha PK, Chan L, Smith RG. Ablation of ghrelin improves the diabetic but not obese phenotype of ob/ob mice. Cell Metab. 2006 May; 3(5):379-86. PMID: 16679295.
      Citations: 132     Fields:    Translation:AnimalsCells
    155. Wang Y, Lam KS, Chan L, Chan KW, Lam JB, Lam MC, Hoo RC, Mak WW, Cooper GJ, Xu A. Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem. 2006 Jun 16; 281(24):16391-400. PMID: 16621799.
      Citations: 86     Fields:    Translation:HumansAnimalsCells
    156. Ma K, Saha PK, Chan L, Moore DD. Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest. 2006 Apr; 116(4):1102-9. PMID: 16557297; PMCID: PMC1409738.
      Citations: 302     Fields:    Translation:AnimalsCells
    157. Samson SL, Chan L. Gene therapy for diabetes: reinventing the islet. Trends Endocrinol Metab. 2006 Apr; 17(3):92-100. PMID: 16504534.
      Citations: 11     Fields:    Translation:Humans
    158. Chang BH, Li L, Paul A, Taniguchi S, Nannegari V, Heird WC, Chan L. Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol. 2006 Feb; 26(3):1063-76. PMID: 16428458; PMCID: PMC1347045.
      Citations: 137     Fields:    Translation:AnimalsCells
    159. Chan L, Terashima T, Fujimiya M, Kojima H. Chronic diabetic complications: the body's adaptive response to hyperglycemia gone awry? Trans Am Clin Climatol Assoc. 2006; 117:341-51; discussion 351-2. PMID: 18528485; PMCID: PMC1500919.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    160. Oka K, Chan L. Helper-dependent adenoviral vectors. Curr Protoc Hum Genet. 2005 Nov; Chapter 12:Unit 12.13. PMID: 18428374.
      Citations: 1     Fields:    Translation:HumansCells
    161. Lau PP, Li L, Merched AJ, Zhang AL, Ko KW, Chan L. Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice. Arterioscler Thromb Vasc Biol. 2006 Jan; 26(1):143-9. PMID: 16254210.
      Citations: 37     Fields:    Translation:AnimalsCells
    162. Paul A, Yeh ET, Chan L. A proatherogenic role for C-reactive protein in vivo. Curr Opin Lipidol. 2005 Oct; 16(5):512-7. PMID: 16148535.
      Citations: 9     Fields:    Translation:HumansAnimals
    163. Wang L, Liu J, Saha P, Huang J, Chan L, Spiegelman B, Moore DD. The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab. 2005 Oct; 2(4):227-38. PMID: 16213225.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    164. Ko KW, Paul A, Ma K, Li L, Chan L. Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res. 2005 Dec; 46(12):2586-94. PMID: 16199802.
      Citations: 28     Fields:    Translation:AnimalsCells
    165. Schillinger KJ, Tsai SY, Taffet GE, Reddy AK, Marian AJ, Entman ML, Oka K, Chan L, O'Malley BW. Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A. 2005 Sep 27; 102(39):13789-94. PMID: 16162668; PMCID: PMC1236585.
      Citations: 22     Fields:    Translation:AnimalsCells
    166. Terashima T, Kojima H, Fujimiya M, Matsumura K, Oi J, Hara M, Kashiwagi A, Kimura H, Yasuda H, Chan L. The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc Natl Acad Sci U S A. 2005 Aug 30; 102(35):12525-30. PMID: 16116088; PMCID: PMC1194942.
      Citations: 26     Fields:    Translation:AnimalsCells
    167. Oka K, Chan L. Inhibition and regression of atherosclerotic lesions. Acta Biochim Pol. 2005; 52(2):311-9. PMID: 15940346; PMCID: PMC1360606.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    168. Oka K, Chan L. Helper-dependent adenoviral vectors. Curr Protoc Mol Biol. 2005 Feb; Chapter 16:Unit 16.24. PMID: 18265354.
      Citations:    Fields:    Translation:Cells
    169. Oka K, Chan L. Construction and characterization of helper-dependent adenoviral vectors for sustained in vivo gene therapy. Methods Mol Med. 2005; 108:329-50. PMID: 16028693.
      Citations: 2     Fields:    Translation:HumansCells
    170. Merched AJ, Chan L. Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis. Circulation. 2004 Dec 21; 110(25):3830-41. PMID: 15596565.
      Citations: 25     Fields:    Translation:AnimalsCells
    171. Ma K, Forte T, Otvos JD, Chan L. Differential additive effects of endothelial lipase and scavenger receptor-class B type I on high-density lipoprotein metabolism in knockout mouse models. Arterioscler Thromb Vasc Biol. 2005 Jan; 25(1):149-54. PMID: 15539616.
      Citations: 14     Fields:    Translation:Animals
    172. el Marjou F, Janssen KP, Chang BH, Li M, Chan L, Louvard D, Chambon P, Metzger D, Robine S, Hindie V. Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis. 2004 Jul; 39(3):186-93. PMID: 15282745.
      Citations: 578     Fields:    Translation:AnimalsCells
    173. Saha PK, Kojima H, Martinez-Botas J, Sunehag AL, Chan L. Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem. 2004 Aug 20; 279(34):35150-8. PMID: 15197189.
      Citations: 52     Fields:    Translation:AnimalsCells
    174. Kolonin MG, Saha PK, Chan L, Pasqualini R, Arap W. Reversal of obesity by targeted ablation of adipose tissue. Nat Med. 2004 Jun; 10(6):625-32. PMID: 15133506.
      Citations: 209     Fields:    Translation:HumansAnimalsCells
    175. Oka K, Chan L. Liver-directed gene therapy for dyslipidemia and diabetes. Curr Atheroscler Rep. 2004 May; 6(3):203-9. PMID: 15068745; PMCID: PMC1224746.
      Citations: 3     Fields:    Translation:Humans
    176. Pastore L, Belalcazar LM, Oka K, Cela R, Lee B, Chan L, Beaudet AL. Helper-dependent adenoviral vector-mediated long-term expression of human apolipoprotein A-I reduces atherosclerosis in apo E-deficient mice. Gene. 2004 Mar 03; 327(2):153-60. PMID: 14980712.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    177. Kojima H, Fujimiya M, Matsumura K, Nakahara T, Hara M, Chan L. Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci U S A. 2004 Feb 24; 101(8):2458-63. PMID: 14983031; PMCID: PMC356972.
      Citations: 72     Fields:    Translation:AnimalsCells
    178. Paul A, Ko KW, Li L, Yechoor V, McCrory MA, Szalai AJ, Chan L. C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation. 2004 Feb 10; 109(5):647-55. PMID: 14744975.
      Citations: 100     Fields:    Translation:HumansAnimals
    179. Serhan CN, Jain A, Marleau S, Clish C, Kantarci A, Behbehani B, Colgan SP, Stahl GL, Merched A, Petasis NA, Chan L, Van Dyke TE. Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol. 2003 Dec 15; 171(12):6856-65. PMID: 14662892.
      Citations: 150     Fields:    Translation:HumansAnimalsCells
    180. Castro-Chavez F, Yechoor VK, Saha PK, Martinez-Botas J, Wooten EC, Sharma S, O'Connell P, Taegtmeyer H, Chan L. Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes. 2003 Nov; 52(11):2666-74. PMID: 14578284.
      Citations: 26     Fields:    Translation:AnimalsCells
    181. Lau PP, Chan L. Involvement of a chaperone regulator, Bcl2-associated athanogene-4, in apolipoprotein B mRNA editing. J Biol Chem. 2003 Dec 26; 278(52):52988-96. PMID: 14559896.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    182. Chan L, Fujimiya M, Kojima H. In vivo gene therapy for diabetes mellitus. Trends Mol Med. 2003 Oct; 9(10):430-5. PMID: 14557055.
      Citations: 8     Fields:    Translation:HumansAnimals
    183. Liao W, Chang BH, Mancini M, Chan L. Ubiquitin-dependent and -independent proteasomal degradation of apoB associated with endoplasmic reticulum and Golgi apparatus, respectively, in HepG2 cells. J Cell Biochem. 2003 Aug 01; 89(5):1019-29. PMID: 12874835.
      Citations: 4     Fields:    Translation:HumansCells
    184. Merched AJ, Williams E, Chan L. Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling. Arterioscler Thromb Vasc Biol. 2003 Sep 01; 23(9):1608-14. PMID: 12842843.
      Citations: 41     Fields:    Translation:AnimalsCells
    185. Belalcazar LM, Merched A, Carr B, Oka K, Chen KH, Pastore L, Beaudet A, Chan L. Long-term stable expression of human apolipoprotein A-I mediated by helper-dependent adenovirus gene transfer inhibits atherosclerosis progression and remodels atherosclerotic plaques in a mouse model of familial hypercholesterolemia. Circulation. 2003 Jun 03; 107(21):2726-32. PMID: 12742997.
      Citations: 44     Fields:    Translation:HumansAnimalsCells
    186. Kojima H, Fujimiya M, Matsumura K, Younan P, Imaeda H, Maeda M, Chan L. NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med. 2003 May; 9(5):596-603. PMID: 12704384.
      Citations: 149     Fields:    Translation:AnimalsCells
    187. Ma K, Cilingiroglu M, Otvos JD, Ballantyne CM, Marian AJ, Chan L. Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A. 2003 Mar 04; 100(5):2748-53. PMID: 12601178; PMCID: PMC151412.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    188. Ma K, Cabrero A, Saha PK, Kojima H, Li L, Chang BH, Paul A, Chan L. Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem. 2002 Sep 20; 277(38):34658-61. PMID: 12151381.
      Citations: 119     Fields:    Translation:AnimalsCells
    189. Oka K, Chan L. Recent advances in liver-directed gene therapy for dyslipidemia. Curr Atheroscler Rep. 2002 May; 4(3):199-207. PMID: 11931717.
      Citations: 3     Fields:    Translation:Humans
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