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MICHELE REDELL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Research 
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    R21CA234529     (REDELL, MICHELE S)Dec 1, 2019 - May 31, 2022
    NIH
    High-Dimensional Profiling of Physiological Signaling Responses to Identify Relapse-Driving Cells in Acute Myeloid Leukemia
    Role: Principal Investigator
    R01CA175026     (REDELL, MICHELE S)Aug 1, 2014 - Jul 30, 2019
    NIH
    Using Stat3 Signaling Profiles to Understand Chemotherapy Resistance in AML
    Role: Principal Investigator
    K08HL085018     (REDELL, MICHELE S)Sep 10, 2008 - May 31, 2013
    NIH
    Stat3 Isoforms in Maturation and Survival of Normal and Malignant Myeloid Cells
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Stevens AM, Terrell M, Rashid R, Fisher KE, Marcogliese AN, Gaikwad A, Rao P, Vrana C, Krueger M, Loken M, Menssen AJ, Cook JA, Keogh N, Alozie M, Oviedo H, Gonzalez AK, Ilangovan T, Kim J, Sandhu S, Redell MS. Addressing a Pre-Clinical Pipeline Gap: Development of the Pediatric Acute Myeloid Leukemia Patient-Derived Xenograft Program at Texas Children's Hospital at Baylor College of Medicine. Biomedicines. 2024 Feb 08; 12(2). PMID: 38397996; PMCID: PMC10886789.
      Citations:    
    2. Brivio E, Pennesi E, Willemse ME, Huitema ADR, Jiang Y, van Tinteren HDR, van der Velden VHJ, Beverloo BH, den Boer ML, Rammeloo LAJ, Hudson C, Heerema N, Kowalski K, Zhao H, Kuttschreuter L, Bautista Sirvent FJ, Bukowinski A, Rizzari C, Pollard J, Murillo-Sanju?n L, Kutny M, Zarnegar-Lumley S, Redell M, Cooper S, Bertrand Y, Petit A, Krystal J, Metzler M, Lancaster D, Bourquin JP, Motwani J, van der Sluis IM, Locatelli F, Roth ME, Hijiya N, Zwaan CM. Bosutinib in Resistant and Intolerant Pediatric Patients With Chronic Phase Chronic Myeloid Leukemia: Results From the Phase I Part of Study ITCC054/COG AAML1921. J Clin Oncol. 2024 Mar 01; 42(7):821-831. PMID: 38033284; PMCID: PMC10906575.
      Citations:    Fields:    Translation:HumansCTClinical Trials
    3. Shekar M, Llaurador Caraballo G, Punia JN, Curry CV, Fisher KE, Redell MS. ALK Fusion in an Adolescent with Acute Myeloid Leukemia: A Case Report and Review of the Literature. Biomedicines. 2023 Jun 27; 11(7). PMID: 37509482; PMCID: PMC10377196.
      Citations:    
    4. Trabal A, Gibson A, He J, McCall D, Roth M, Nu?ez C, Garcia M, Buzbee M, Toepfer L, Bidikian A, Daver N, Kadia T, Short NJ, Issa GC, Ravandi F, DiNardo CD, Montalban Bravo G, Garces S, Marcogliese A, Paek H, Dreyer Z, Brackett J, Redell M, Yi J, Garcia-Manero G, Konopleva M, Stevens A, Cuglievan B. Venetoclax for Acute Myeloid Leukemia in Pediatric Patients: A Texas Medical Center Experience. Cancers (Basel). 2023 Mar 26; 15(7). PMID: 37046645; PMCID: PMC10093646.
      Citations: 1     
    5. Stevens AM, Schafer ES, Li M, Terrell M, Rashid R, Paek H, Bernhardt MB, Weisnicht A, Smith WT, Keogh NJ, Alozie MC, Oviedo HH, Gonzalez AK, Ilangovan T, Mangubat-Medina A, Wang H, Jo E, Rabik CA, Bocchini C, Hilsenbeck S, Ball ZT, Cooper TM, Redell MS. Repurposing Atovaquone as a Therapeutic against Acute Myeloid Leukemia (AML): Combination with Conventional Chemotherapy Is Feasible and Well Tolerated. Cancers (Basel). 2023 Feb 20; 15(4). PMID: 36831684; PMCID: PMC9954468.
      Citations:    
    6. Stevens AM, Horton TM, Glasser CL, Gerbing RB, Aplenc R, Alonzo TA, Redell MS. IL-10 and TNFa are associated with decreased survival in low-risk pediatric acute myeloid leukemia; a children's oncology group report. Pediatr Hematol Oncol. 2023 Mar; 40(2):147-158. PMID: 35838057; PMCID: PMC10498011.
      Citations:    Fields:    
    7. Youn M, Smith SM, Lee AG, Chae HD, Spiteri E, Erdmann J, Galperin I, Jones LM, Donato M, Abidi P, Bittencourt H, Lacayo N, Dahl G, Aftandilian C, Davis KL, Matthews JA, Kornblau SM, Huang M, Sumarsono N, Redell MS, Fu CH, Chen IM, Alonzo TA, Eklund E, Gotlib J, Khatri P, Sweet-Cordero EA, Hijiya N, Sakamoto KM. Comparison of the Transcriptomic Signatures in Pediatric and Adult CML. Cancers (Basel). 2021 Dec 14; 13(24). PMID: 34944883; PMCID: PMC8699058.
      Citations:    
    8. Stevens AM, Redell MS. Introduction to the Special Issue on Pediatric Acute Myeloid Leukemia: Current Management and Future Directions. Children (Basel). 2021 Aug 12; 8(8). PMID: 34438589; PMCID: PMC8394900.
      Citations:    
    9. Narayanan P, Man TK, Gerbing RB, Ries R, Stevens AM, Wang YC, Long X, Gamis AS, Cooper T, Meshinchi S, Alonzo TA, Redell MS. Aberrantly low STAT3 and STAT5 responses are associated with poor outcome and an inflammatory gene expression signature in pediatric acute myeloid leukemia. Clin Transl Oncol. 2021 Oct; 23(10):2141-2154. PMID: 33948920; PMCID: PMC8390401.
      Citations:    Fields:    Translation:HumansCells
    10. Ataca Atilla P, McKenna MK, Tashiro H, Srinivasan M, Mo F, Watanabe N, Simons BW, McLean Stevens A, Redell MS, Heslop HE, Mamonkin M, Brenner MK, Atilla E. Modulating TNFa activity allows transgenic IL15-Expressing CLL-1 CAR T cells to safely eliminate acute myeloid leukemia. J Immunother Cancer. 2020 09; 8(2). PMID: 32938629; PMCID: PMC7497527.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    11. Minus MB, Wang H, Munoz JO, Stevens AM, Mangubat-Medina AE, Krueger MJ, Liu W, Kasembeli MM, Cooper JC, Kolosov MI, Tweardy DJ, Redell MS, Ball ZT. Targeting STAT3 anti-apoptosis pathways with organic and hybrid organic-inorganic inhibitors. Org Biomol Chem. 2020 05 06; 18(17):3288-3296. PMID: 32286579; PMCID: PMC7286531.
      Citations:    Fields:    Translation:HumansAnimalsCells
    12. Stevens AM, Xiang M, Heppler LN, Jiang K, Munoz JO, Gaikwad AS, Horton TM, Long X, Narayanan P, Seashore EL, Terrell MC, Rashid R, Krueger MJ, Mangubat-Medina AE, Ball ZT, Sumazin P, Walker SR, Hamada Y, Oyadomari S, Redell MS, Frank DA, To?ic I. Atovaquone is active against AML by upregulating the integrated stress pathway and suppressing oxidative phosphorylation. Blood Adv. 2019 12 23; 3(24):4215-4227. PMID: 31856268; PMCID: PMC6929386.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    13. Zhou T, Bloomquist MS, Ferguson LS, Reuther J, Marcogliese AN, Elghetany MT, Roy A, Rao PH, Lopez-Terrada DH, Redell MS, Punia JN, Curry CV, Fisher KE. Pediatric myeloid sarcoma: a single institution clinicopathologic and molecular analysis. Pediatr Hematol Oncol. 2020 Feb; 37(1):76-89. PMID: 31682773.
      Citations: 9     Fields:    Translation:Humans
    14. Athale U, Hijiya N, Patterson BC, Bergsagel J, Andolina JR, Bittencourt H, Schultz KR, Burke MJ, Redell MS, Kolb EA, Johnston DL. Management of chronic myeloid leukemia in children and adolescents: Recommendations from the Children's Oncology Group CML Working Group. Pediatr Blood Cancer. 2019 09; 66(9):e27827. PMID: 31330093; PMCID: PMC6944522.
      Citations: 9     Fields:    Translation:Humans
    15. Boudreaux SP, Duren RP, Call SG, Nguyen L, Freire PR, Narayanan P, Redell MS, Conneely OM. Drug targeting of NR4A nuclear receptors for treatment of acute myeloid leukemia. Leukemia. 2019 01; 33(1):52-63. PMID: 29884904; PMCID: PMC6286710.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    16. Lu L, Wen Y, Yao Y, Chen F, Wang G, Wu F, Wu J, Narayanan P, Redell M, Mo Q, Song Y. Glucocorticoids Inhibit Oncogenic RUNX1-ETO in Acute Myeloid Leukemia with Chromosome Translocation t(8;21). Theranostics. 2018; 8(8):2189-2201. PMID: 29721072; PMCID: PMC5928880.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    17. Long X, Gerbing RB, Alonzo TA, Redell MS. Distinct signaling events promote resistance to mitoxantrone and etoposide in pediatric AML: a Children's Oncology Group report. Oncotarget. 2017 Oct 27; 8(52):90037-90049. PMID: 29163809; PMCID: PMC5685730.
      Citations: 2     Fields:    
    18. Stevens AM, Miller JM, Munoz JO, Gaikwad AS, Redell MS. Interleukin-6 levels predict event-free survival in pediatric AML and suggest a mechanism of chemotherapy resistance. Blood Adv. 2017 Aug 08; 1(18):1387-1397. PMID: 29296780; PMCID: PMC5727855.
      Citations: 22     Fields:    
    19. Gramatges MM, Deshpande A, Lupo PJ, Rau RE, Redell ML, Horton TM, Scheurer ME, Rabin KR. Ethnic disparities relative to disease features and outcomes in children with acute myeloid leukemia. Pediatr Blood Cancer. 2017 Sep; 64(9). PMID: 28266784.
      Citations: 5     Fields:    Translation:Humans
    20. Minus MB, Kang MK, Knudsen SE, Liu W, Krueger MJ, Smith ML, Redell MS, Ball ZT. Assessing the intracellular fate of rhodium(ii) complexes. Chem Commun (Camb). 2016 Sep 22; 52(78):11685-11688. PMID: 27709185; PMCID: PMC5076564.
      Citations: 2     Fields:    
    21. Bonifant CL, Szoor A, Torres D, Joseph N, Velasquez MP, Iwahori K, Gaikwad A, Nguyen P, Arber C, Song XT, Redell M, Gottschalk S. CD123-Engager T Cells as a Novel Immunotherapeutic for Acute Myeloid Leukemia. Mol Ther. 2016 09 29; 24(9):1615-26. PMID: 27401038; PMCID: PMC5113097.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    22. Feng Z, Yao Y, Zhou C, Chen F, Wu F, Wei L, Liu W, Dong S, Redell M, Mo Q, Song Y. Pharmacological inhibition of LSD1 for the treatment of MLL-rearranged leukemia. J Hematol Oncol. 2016 Mar 12; 9:24. PMID: 26970896; PMCID: PMC4789278.
      Citations: 48     Fields:    Translation:HumansAnimalsCells
    23. Minus MB, Liu W, Vohidov F, Kasembeli MM, Long X, Krueger MJ, Stevens A, Kolosov MI, Tweardy DJ, Sison EA, Redell MS, Ball ZT. Rhodium(II) Proximity-Labeling Identifies a Novel Target Site on STAT3 for Inhibitors with Potent Anti-Leukemia Activity. Angew Chem Int Ed Engl. 2015 Oct 26; 54(44):13085-9. PMID: 26480340; PMCID: PMC5041597.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    24. Fang M, Becker PS, Linenberger M, Eaton KD, Appelbaum FR, Dreyer Z, Airewele G, Redell M, Lopez-Terrada D, Patel A, Rabin KR, Lu X. Adult Low-Hypodiploid Acute B-Lymphoblastic Leukemia With IKZF3 Deletion and TP53 Mutation: Comparison With Pediatric Patients. Am J Clin Pathol. 2015 Aug; 144(2):263-70. PMID: 26185311.
      Citations: 3     Fields:    Translation:Humans
    25. Long X, Yu Y, Perlaky L, Man TK, Redell MS. Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia. Br J Haematol. 2015 Sep; 170(5):704-18. PMID: 25974135; PMCID: PMC5490799.
      Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
    26. Liu W, Deng L, Song Y, Redell M. DOT1L inhibition sensitizes MLL-rearranged AML to chemotherapy. PLoS One. 2014; 9(5):e98270. PMID: 24858818; PMCID: PMC4032273.
      Citations: 41     Fields:    Translation:HumansCells
    27. Blanco EM, Curry CV, Lu XY, Sarabia SF, Redell MS, Lopez-Terrada DH, Roy A. Cytogenetically cryptic and FISH-negative PML/RARA rearrangement in acute promyelocytic leukemia detected only by PCR: an exceedingly rare phenomenon. Cancer Genet. 2014 Jan-Feb; 207(1-2):48-9. PMID: 24561214.
      Citations: 13     Fields:    Translation:HumansCells
    28. Deng L, Zhang L, Yao Y, Wang C, Redell MS, Dong S, Song Y. Synthesis, Activity and Metabolic Stability of Non-Ribose Containing Inhibitors of Histone Methyltransferase DOT1L. Medchemcomm. 2013 May 01; 4(5):822-826. PMID: 23795283; PMCID: PMC3686528.
      Citations: 18     
    29. Fallon SC, Redell MS, El-Bietar J, Lopez ME, Vasudevan SA, Brandt ML. Intestinal perforation after treatment of Burkitt's lymphoma: case report and review of the literature. J Pediatr Surg. 2013 Feb; 48(2):436-40. PMID: 23414881.
      Citations: 4     Fields:    Translation:Humans
    30. Redell MS, Ruiz MJ, Gerbing RB, Alonzo TA, Lange BJ, Tweardy DJ, Meshinchi S, Children's Oncology Group. FACS analysis of Stat3/5 signaling reveals sensitivity to G-CSF and IL-6 as a significant prognostic factor in pediatric AML: a Children's Oncology Group report. Blood. 2013 Feb 14; 121(7):1083-93. PMID: 23243289; PMCID: PMC3575754.
      Citations: 21     Fields:    Translation:HumansCells
    31. Redell MS, Ruiz MJ, Alonzo TA, Gerbing RB, Tweardy DJ. Stat3 signaling in acute myeloid leukemia: ligand-dependent and -independent activation and induction of apoptosis by a novel small-molecule Stat3 inhibitor. Blood. 2011 May 26; 117(21):5701-9. PMID: 21447830; PMCID: PMC3110027.
      Citations: 103     Fields:    Translation:HumansCells
    32. Huang Y, Qiu J, Dong S, Redell MS, Poli V, Mancini MA, Tweardy DJ. Stat3 isoforms, alpha and beta, demonstrate distinct intracellular dynamics with prolonged nuclear retention of Stat3beta mapping to its unique C-terminal end. J Biol Chem. 2007 Nov 30; 282(48):34958-67. PMID: 17855361.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    33. Redell MS, Tsimelzon A, Hilsenbeck SG, Tweardy DJ. Conditional overexpression of Stat3alpha in differentiating myeloid cells results in neutrophil expansion and induces a distinct, antiapoptotic and pro-oncogenic gene expression pattern. J Leukoc Biol. 2007 Oct; 82(4):975-85. PMID: 17634277.
      Citations: 9     Fields:    Translation:AnimalsCells
    34. Redell MS, Tweardy DJ. Targeting transcription factors in cancer: Challenges and evolving strategies. Drug Discov Today Technol. 2006; 3(3):261-7. PMID: 24980527.
      Citations: 9     Fields:    
    35. Redell MS, Tweardy DJ. Targeting transcription factors for cancer therapy. Curr Pharm Des. 2005; 11(22):2873-87. PMID: 16101443.
      Citations: 26     Fields:    Translation:HumansAnimals
    36. Terman GW, Drake CT, Simmons ML, Milner TA, Chavkin C. Opioid modulation of recurrent excitation in the hippocampal dentate gyrus. J Neurosci. 2000 Jun 15; 20(12):4379-88. PMID: 10844006; PMCID: PMC6772439.
      Citations: 22     Fields:    Translation:AnimalsCells
    37. Simmons ML, Terman GW, Chavkin C. Spontaneous excitatory currents and kappa-opioid receptor inhibition in dentate gyrus are increased in the rat pilocarpine model of temporal lobe epilepsy. J Neurophysiol. 1997 Oct; 78(4):1860-8. PMID: 9325355.
      Citations: 10     Fields:    Translation:AnimalsCells
    38. Drake CT, Patterson TA, Simmons ML, Chavkin C, Milner TA. Kappa opioid receptor-like immunoreactivity in guinea pig brain: ultrastructural localization in presynaptic terminals in hippocampal formation. J Comp Neurol. 1996 Jul 01; 370(3):377-95. PMID: 8799863.
      Citations: 23     Fields:    Translation:AnimalsCells
    39. Simmons ML, Chavkin C. k-Opioid receptor activation of a dendrotoxin-sensitive potassium channel mediates presynaptic inhibition of mossy fiber neurotransmitter release. Mol Pharmacol. 1996 Jul; 50(1):80-5. PMID: 8700123.
      Citations: 31     Fields:    Translation:AnimalsCells
    40. Simmons ML, Terman GW, Gibbs SM, Chavkin C. L-type calcium channels mediate dynorphin neuropeptide release from dendrites but not axons of hippocampal granule cells. Neuron. 1995 Jun; 14(6):1265-72. PMID: 7605635.
      Citations: 36     Fields:    Translation:AnimalsCells
    41. Wu ZL, Thomas SA, Villacres EC, Xia Z, Simmons ML, Chavkin C, Palmiter RD, Storm DR. Altered behavior and long-term potentiation in type I adenylyl cyclase mutant mice. Proc Natl Acad Sci U S A. 1995 Jan 03; 92(1):220-4. PMID: 7816821; PMCID: PMC42849.
      Citations: 109     Fields:    Translation:AnimalsCells
    42. Simmons ML, Terman GW, Drake CT, Chavkin C. Inhibition of glutamate release by presynaptic kappa 1-opioid receptors in the guinea pig dentate gyrus. J Neurophysiol. 1994 Oct; 72(4):1697-705. PMID: 7823095.
      Citations: 9     Fields:    Translation:AnimalsCells
    43. Drake CT, Terman GW, Simmons ML, Milner TA, Kunkel DD, Schwartzkroin PA, Chavkin C. Dynorphin opioids present in dentate granule cells may function as retrograde inhibitory neurotransmitters. J Neurosci. 1994 Jun; 14(6):3736-50. PMID: 7911518; PMCID: PMC6576943.
      Citations: 45     Fields:    Translation:AnimalsCells
    44. Simmons ML, Wagner JJ, Caudle RM, Chavkin C. Endogenous opioid regulation of norepinephrine release in guinea pig hippocampus. Neurosci Lett. 1992 Jul 06; 141(1):84-8. PMID: 1508405.
      Citations: 1     Fields:    Translation:Animals
    45. Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience. 1991; 45(1):37-45. PMID: 1754068.
      Citations: 136     Fields:    Translation:AnimalsCells
    46. Slusher BS, Robinson MB, Tsai G, Simmons ML, Richards SS, Coyle JT. Rat brain N-acetylated alpha-linked acidic dipeptidase activity. Purification and immunologic characterization. J Biol Chem. 1990 Dec 05; 265(34):21297-301. PMID: 2250024.
      Citations: 20     Fields:    Translation:AnimalsCells
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