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MARIA BOTTAZZI

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular Virology & Microbiology
    DivisionMolecular Virology & Microbiology


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    R21AI144891     (LIN, YI-PIN)Feb 1, 2020 - Jan 31, 2022
    NIH
    Identification of the mechanism of protection against a B. burgdorferi protein CspZ for the prevention of Lyme disease
    Role: Co-Principal Investigator
         (Peter Hotez)Apr 1, 2019 - Mar 31, 2021
    NIH
    A novel mucosal trichuriasis vaccine for TH2 immune protection
    Role: Co-Investigator
    R13AI142711     (BOTTAZZI, MARIA ELENA)Feb 6, 2019 - Apr 30, 2019
    NIH
    2019 Tropical Infectious Diseases
    Role: Principal Investigator
         (Peter Hotez)Nov 1, 2018 - Oct 31, 2022
    CDMRP
    Phase I/IIb Testing of the Sm-TSP-2 Schistosomiasis Vaccine in Uganda
    Role: Project Leader
    W81XWH-17-2-0050     (Peter Hotez)Sep 15, 2017 - Sep 14, 2020
    CDMRP
    A vaccine to prevent leishmaniasis
    Role: Co-Investigator
    2RO1AI078314-06A1     (Sara Lustigman)Apr 11, 2017 - Feb 28, 2022
    New York Blood Center
    TEh Development of a recombinant vaccine against onchocerciasis
    Role: BCM Principal Invvestigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Bartsch SM, O'Shea KJ, Weatherwax C, Strych U, Velmurugan K, John DC, Bottazzi ME, Hussein M, Martinez MF, Chin KL, Ciciriello A, Heneghan J, Dibbs A, Scannell SA, Hotez PJ, Lee BY. What is the economic benefit of annual COVID-19 vaccination from the adult individual perspective? J Infect Dis. 2024 Apr 06. PMID: 38581432.
      Citations:    
    2. Mancino C, Pollet J, Zinger A, Jones KM, Villar MJ, Leao AC, Adhikari R, Versteeg L, Tyagi Kundu R, Strych U, Giordano F, Hotez PJ, Bottazzi ME, Taraballi F, Poveda C. Harnessing RNA Technology to Advance Therapeutic Vaccine Antigens against Chagas Disease. ACS Appl Mater Interfaces. 2024 Apr 03; 16(13):15832-15846. PMID: 38518375; PMCID: PMC10996878.
      Citations:    Fields:    
    3. Zinsou JF, Diemert DJ, Dejon-Agob? JC, Ad?gbit? BR, Honkpehedji YJ, Vodonou KG, Bikangui R, Edoa JR, Massinga Loembe M, Li G, Yazdanbakhsh M, Bottazzi ME, van Leeuwen R, Kremsner PG, Hotez PJ, Bethony JM, Grobusch MP, Adegnika AA. Safety and immunogenicity of the co-administered Na-APR-1 and Na-GST-1 hookworm vaccines in school-aged children in Gabon: a randomised, controlled, observer-blind, phase 1, dose-escalation trial. Lancet Infect Dis. 2024 Mar 18. PMID: 38513684.
      Citations:    Fields:    
    4. C?rdenas-Guerra RE, Montes-Flores O, Nava-Pintor EE, Res?ndiz-Cardiel G, Flores-Pucheta CI, Rodr?guez-Gavald?n YI, Arroyo R, Bottazzi ME, Hotez PJ, Ortega-L?pez J. Chagasin from Trypanosoma cruzi as a molecular scaffold to express epitopes of TSA-1 as soluble recombinant chimeras. Protein Expr Purif. 2024 Jun; 218:106458. PMID: 38423156.
      Citations:    Fields:    Translation:AnimalsCells
    5. McKim S, Kopystynsky K, Wolf N, Akbar FA, Bottazzi ME, Hotez PJ, Mejia R. Environmental Detection of Parasites in the Marginalized Paiute Reservations Compared to a Nearby Area. Am J Trop Med Hyg. 2024 Mar 06; 110(3):457-459. PMID: 38350146; PMCID: PMC10919181.
      Citations:    Fields:    Translation:HumansAnimals
    6. Wu Y, Adeniyi-Ipadeola G, Adkins-Threats M, Seasock M, Suarez-Reyes C, Fujiwara R, Bottazzi ME, Song L, Mills JC, Weatherhead JE. Host gastric corpus microenvironment facilitates Ascaris suum larval hatching and infection in a murine model. PLoS Negl Trop Dis. 2024 Feb; 18(2):e0011930. PMID: 38324590; PMCID: PMC10878500.
      Citations:    Fields:    Translation:HumansAnimals
    7. Bartsch SM, O'Shea KJ, John DC, Strych U, Bottazzi ME, Martinez MF, Ciciriello A, Chin KL, Weatherwax C, Velmurugan K, Heneghan J, Scannell SA, Hotez PJ, Lee BY. The potential epidemiologic, clinical, and economic value of a universal coronavirus vaccine: a modelling study. EClinicalMedicine. 2024 Feb; 68:102369. PMID: 38545093; PMCID: PMC10965405.
      Citations:    
    8. Chen YL, Lee J, Liu Z, Strych U, Bottazzi ME, Lin YP, Chen WH, Lin YP. Biophysical and biochemical characterization of a recombinant Lyme disease vaccine antigen, CspZ-YA. Int J Biol Macromol. 2024 Feb; 259(Pt 2):129295. PMID: 38211914.
      Citations:    Fields:    Translation:HumansCells
    9. Nguyen DM, Poveda C, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2023 Nov; 17(11):e0011519. PMID: 37988389; PMCID: PMC10697595.
      Citations:    Fields:    Translation:Animals
    10. Wu Y, Green FM, Shaw SA, Bonilla LJ, Ronca SE, Bottazzi ME, Kheradmand F, Weatherhead JE. SARS-CoV-2 triggers Dickkopf-1 (Dkk-1) modulation of T helper cells and lung pathology in mice. Genes Dis. 2024 Jul; 11(4):101167. PMID: 38362044; PMCID: PMC10865256.
      Citations:    
    11. McKim S, Kopystynsky K, Wolf N, Akbar FA, Bottazzi ME, Hotez PJ, Mejia R. Environmental detection of parasites in the marginalized Paiute reservations compared to a nearby area. medRxiv. 2023 Oct 25. PMID: 37961205; PMCID: PMC10635189.
      Citations:    
    12. Liu Z, Ulrich vonBargen R, Kendricks AL, Wheeler K, Le?o AC, Sankaranarayanan K, Dean DA, Kane SS, Hossain E, Pollet J, Bottazzi ME, Hotez PJ, Jones KM, McCall LI. Localized cardiac small molecule trajectories and persistent chemical sequelae in experimental Chagas disease. Nat Commun. 2023 10 25; 14(1):6769. PMID: 37880260; PMCID: PMC10600178.
      Citations: 3     Fields:    Translation:Animals
    13. Mahoney R, Hotez PJ, Bottazzi ME. Global regulatory reforms to promote equitable vaccine access in the next pandemic. PLOS Glob Public Health. 2023; 3(10):e0002482. PMID: 37851688; PMCID: PMC10584090.
      Citations: 1     
    14. Puchner KP, Bottazzi ME, Periago V, Grobusch M, Maizels R, McCarthy J, Lee B, Gaspari E, Diemert D, Hotez P. Vaccine value profile for Hookworm. Vaccine. 2023 Oct 18. PMID: 37863671.
      Citations: 1     Fields:    
    15. Hotez PJ, Bottazzi ME, Kaye PM, Lee BY, Puchner KP. Neglected tropical disease vaccines: hookworm, leishmaniasis, and schistosomiasis. Vaccine. 2023 Nov 03; 41 Suppl 2:S176-S179. PMID: 38407985; PMCID: PMC10713477.
      Citations:    Fields:    Translation:HumansAnimals
    16. Thimmiraju SR, Adhikari R, Villar MJ, Lee J, Liu Z, Kundu R, Chen YL, Sharma S, Ghei K, Keegan B, Versteeg L, Gillespie PM, Ciciriello A, Islam NY, Poveda C, Uzcategui N, Chen WH, Kimata JT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Pollet J. A Recombinant Protein XBB.1.5 RBD/Alum/CpG Vaccine Elicits High Neutralizing Antibody Titers against Omicron Subvariants of SARS-CoV-2. Vaccines (Basel). 2023 Oct 01; 11(10). PMID: 37896960; PMCID: PMC10610638.
      Citations: 2     
    17. Yao L, Chemaitelly H, Goldman E, Gudina EK, Khalil A, Ahmed R, James AB, Roca A, Fallah MP, Macnab A, Cho WC, Eikelboom J, Qamar FN, Kremsner P, Oliu-Barton M, Sisa I, Tadesse BT, Marks F, Wang L, Kim JH, Meng X, Wang Y, Fly AD, Wang CY, Day SW, Howard SC, Graff JC, Maida M, Ray K, Franco-Paredes C, Mashe T, Ngongo N, Kaseya J, Ndembi N, Hu Y, Bottazzi ME, Hotez PJ, Ishii KJ, Wang G, Sun D, Aleya L, Gu W. Time to establish an international vaccine candidate pool for potential highly infectious respiratory disease: a community's view. EClinicalMedicine. 2023 Oct; 64:102222. PMID: 37811488; PMCID: PMC10550631.
      Citations:    
    18. Poveda C, Mancino C, Taraballi F, Chen YL, Adhikari R, Villar MJ, Kundu R, Nguyen DM, Versteeg L, Strych U, Hotez PJ, Bottazzi ME, Pollet J, Jones KM, Le?o AC. Heterologous mRNA-protein vaccination with Tc24 induces a robust cellular immune response against Trypanosoma cruzi, characterized by an increased level of polyfunctional CD8+ T-cells. Curr Res Immunol. 2023; 4:100066. PMID: 37534309; PMCID: PMC10393535.
      Citations: 1     
    19. Cl?maco MC, de Figueiredo LA, Lucas RC, Pinheiro GRG, Dias Magalh?es LM, Oliveira ALG, Almeida RM, Barbosa FS, Castanheira Bartholomeu D, Bueno LL, Mendes TA, Zhan B, Jones KM, Hotez P, Bottazzi ME, Oliveira FMS, Fujiwara RT. Development of chimeric protein as a multivalent vaccine for human Kinetoplastid infections: Chagas disease and leishmaniasis. Vaccine. 2023 08 23; 41(37):5400-5411. PMID: 37479612.
      Citations:    Fields:    Translation:HumansAnimals
    20. Nguyen DM, Poveda C, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection. bioRxiv. 2023 Jul 12. PMID: 37503013; PMCID: PMC10369866.
      Citations:    
    21. Ryan NM, Hess JA, Robertson EJ, Tricoche N, Turner C, Davis J, Petrovsky N, Ferguson M, Rinaldi WJ, Wong VM, Shimada A, Zhan B, Bottazzi ME, Makepeace BL, Gray SA, Carter D, Lustigman S, Abraham D. Adjuvanted Fusion Protein Vaccine Induces Durable Immunity to Onchocerca volvulus in Mice and Non-Human Primates. Vaccines (Basel). 2023 Jul 06; 11(7). PMID: 37515028; PMCID: PMC10385774.
      Citations: 1     
    22. Casta?eda S, Mu?oz M, Hotez PJ, Bottazzi ME, Paniz-Mondolfi AE, Jones KM, Mejia R, Poveda C, Ram?rez JD. Microbiome Alterations Driven by Trypanosoma cruzi Infection in Two Disjunctive Murine Models. Microbiol Spectr. 2023 06 15; 11(3):e0019923. PMID: 37140369; PMCID: PMC10269900.
      Citations:    Fields:    Translation:Animals
    23. Shoham S, Batista C, Ben Amor Y, Ergonul O, Hassanain M, Hotez P, Kang G, Kim JH, Lall B, Larson HJ, Naniche D, Sheahan T, Strub-Wourgaft N, Sow SO, Wilder-Smith A, Yadav P, Bottazzi ME, Lancet Commission on COVID-19 Vaccines and Therapeutics Task Force. Vaccines and therapeutics for immunocompromised patients with COVID-19. EClinicalMedicine. 2023 May; 59:101965. PMID: 37070102; PMCID: PMC10091856.
      Citations: 2     
    24. Teh-Poot CF, Dzul-Huchim VM, Mercado JM, Villanueva-Lizama LE, Bottazzi ME, Jones KM, Tsai FTF, Cruz-Chan JV. A short-term method to evaluate anti-leishmania drugs by inhibition of stage differentiation in Leishmania mexicana using flow cytometry. Exp Parasitol. 2023 Jun; 249:108519. PMID: 37004860; PMCID: PMC10231665.
      Citations:    Fields:    Translation:HumansAnimals
    25. Diemert DJ, Correa-Oliveira R, Fraga CG, Talles F, Silva MR, Patel SM, Galbiati S, Kennedy JK, Lundeen JS, Gazzinelli MF, Li G, Hoeweler L, Deye GA, Bottazzi ME, Hotez PJ, El Sahly HM, Keitel WA, Bethony J, Atmar RL. A randomized, controlled Phase 1b trial of the Sm-TSP-2 Vaccine for intestinal schistosomiasis in healthy Brazilian adults living in an endemic area. PLoS Negl Trop Dis. 2023 03; 17(3):e0011236. PMID: 36996185; PMCID: PMC10089325.
      Citations: 1     Fields:    Translation:HumansAnimalsCTClinical Trials
    26. Hotez PJ, Bottazzi ME. Human Schistosomiasis Vaccines as Next Generation Control Tools. Trop Med Infect Dis. 2023 Mar 14; 8(3). PMID: 36977171; PMCID: PMC10054132.
      Citations:    
    27. Jones KM, Mangin EN, Reynolds CL, Villanueva LE, Cruz JV, Versteeg L, Keegan B, Kendricks A, Pollet J, Gusovsky F, Bottazzi ME, Hotez PJ. Vaccine-linked chemotherapy improves cardiac structure and function in a mouse model of chronic Chagas disease. Front Cell Infect Microbiol. 2023; 13:1106315. PMID: 36844399; PMCID: PMC9947347.
      Citations: 1     Fields:    Translation:Animals
    28. Nath SK, Pankajakshan P, Sharma T, Kumari P, Shinde S, Garg N, Mathur K, Arambam N, Harjani D, Raj M, Kwatra G, Venkatesh S, Choudhoury A, Bano S, Tayal P, Sharan M, Arora R, Strych U, Hotez PJ, Bottazzi ME, Rawal K. A Data-Driven Approach to Construct a Molecular Map of Trypanosoma cruzi to Identify Drugs and Vaccine Targets. Vaccines (Basel). 2023 Jan 26; 11(2). PMID: 36851145; PMCID: PMC9963959.
      Citations:    
    29. Liu Z, Ulrich R, Kendricks AL, Wheeler K, Le?o AC, Pollet J, Bottazzi ME, Hotez P, Gusovsky F, Jones KM, McCall LI. Localized cardiac metabolic trajectories and post-infectious metabolic sequelae in experimental Chagas disease. Res Sq. 2023 Jan 20. PMID: 36711878; PMCID: PMC9882638.
      Citations:    
    30. Uzoechi SC, Rosa BA, Singh KS, Choi YJ, Bracken BK, Brindley PJ, Townsend RR, Sprung R, Zhan B, Bottazzi ME, Hawdon JM, Wong Y, Loukas A, Djuranovic S, Mitreva M. Excretory/Secretory Proteome of Females and Males of the Hookworm Ancylostoma ceylanicum. Pathogens. 2023 Jan 06; 12(1). PMID: 36678443; PMCID: PMC9865600.
      Citations:    
    31. Hotez PJ, Adhikari R, Chen WH, Chen YL, Gillespie P, Islam NY, Keegan B, Tyagi Kundu R, Lee J, Liu Z, Kimata JT, Oezguen N, Pollet J, Poveda C, Razavi K, Ronca SE, Strych U, Thimmiraju SR, Versteeg L, Villar-Mondragon MJ, Wei J, Zhan B, Bottazzi ME. From concept to delivery: a yeast-expressed recombinant protein-based COVID-19 vaccine technology suitable for global access. Expert Rev Vaccines. 2023 Jan-Dec; 22(1):495-500. PMID: 37252854.
      Citations:    Fields:    Translation:HumansAnimalsCells
    32. Preeti P, Nath SK, Arambam N, Sharma T, Choudhury PR, Choudhury A, Khanna V, Strych U, Hotez PJ, Bottazzi ME, Rawal K. Vaxi-DL: An Artificial Intelligence-Enabled Platform for Vaccine Development. Methods Mol Biol. 2023; 2673:305-316. PMID: 37258923.
      Citations:    Fields:    Translation:Animals
    33. Matthews S, Tannis A, Puchner KP, Bottazzi ME, Cafferata ML, Comand? D, Buekens P. Estimation of the morbidity and mortality of congenital Chagas disease: A systematic review and meta-analysis. PLoS Negl Trop Dis. 2022 11; 16(11):e0010376. PMID: 36342961; PMCID: PMC9671465.
      Citations: 2     Fields:    Translation:HumansAnimals
    34. Osterholm MT, Rabad?n-Diehl C, Anzinger J, Bottazzi ME, Christie-Samuels C, Erondu N, Marrazzo J, Milan S, Quashie PK, Schwaab T, Williams D. Executive Summary: Insights from Cuba's COVID-19 Vaccine Enterprise: Report from a High Level Fact-Finding Delegation to Cuba. MEDICC Rev. 2022 10 31; 24(3-4):109-128. PMID: 36417339.
      Citations: 1     Fields:    Translation:Humans
    35. Osterholm MT, Rabad?n-Diehl C, Anzinger J, Bottazzi ME, Christie-Samuels C, Erondu N, Marrazzo J, Milan S, Quashie PK, Schwaab T, Williams D. Full Technical Report: Insights from Cuba's COVID-19 Vaccine Enterprise: Report from a High Level Fact-Finding Delegation to Cuba. MEDICC Rev. 2022 10 31; 24(3-4):72-108. PMID: 36417340.
      Citations:    Fields:    Translation:Humans
    36. Betouke Ongwe ME, Mouwenda YD, Stam KA, Kremsner PG, Lell B, Diemert D, Bethony J, Bottazzi ME, Hotez PJ, Leeuwen RV, Grobusch MP, Adegnika AA, Mayboroda OA, Yazdanbakhsh M. Investigation of urinary metabolomics in a phase I hookworm vaccine trial in Gabon. PLoS One. 2022; 17(9):e0275013. PMID: 36155987; PMCID: PMC9512193.
      Citations:    Fields:    Translation:HumansAnimalsCTClinical Trials
    37. Sachs JD, Karim SSA, Aknin L, Allen J, Brosb?l K, Colombo F, Barron GC, Espinosa MF, Gaspar V, Gaviria A, Haines A, Hotez PJ, Koundouri P, Bascu??n FL, Lee JK, Pate MA, Ramos G, Reddy KS, Serageldin I, Thwaites J, Vike-Freiberga V, Wang C, Were MK, Xue L, Bahadur C, Bottazzi ME, Bullen C, Laryea-Adjei G, Ben Amor Y, Karadag O, Lafortune G, Torres E, Barredo L, Bartels JGE, Joshi N, Hellard M, Huynh UK, Khandelwal S, Lazarus JV, Michie S. The Lancet Commission on lessons for the future from the COVID-19 pandemic. Lancet. 2022 10 08; 400(10359):1224-1280. PMID: 36115368; PMCID: PMC9539542.
      Citations:    
    38. Chen WH, Strych U, Bottazzi ME, Lin YP. Past, present, and future of Lyme disease vaccines: antigen engineering approaches and mechanistic insights. Expert Rev Vaccines. 2022 10; 21(10):1405-1417. PMID: 35836340; PMCID: PMC9529901.
      Citations:    Fields:    
    39. Chen YL, Marcinkiewicz AL, Nowak TA, Tyagi Kundu R, Liu Z, Strych U, Bottazzi ME, Chen WH, Lin YP. CspZ FH-Binding Sites as Epitopes Promote Antibody-Mediated Lyme Borreliae Clearance. Infect Immun. 2022 07 21; 90(7):e0006222. PMID: 35861564; PMCID: PMC9302089.
      Citations:    Fields:    Translation:AnimalsCells
    40. Jones KM, Poveda C, Versteeg L, Bottazzi ME, Hotez PJ. Preclinical advances and the immunophysiology of a new therapeutic Chagas disease vaccine. Expert Rev Vaccines. 2022 09; 21(9):1185-1203. PMID: 35735065.
      Citations:    Fields:    
    41. Luu L, Hartley CS, Glover AF, Walsh TR, Lian LY, Zhan B, Bottazzi ME, Abraham D, Petrovsky N, Ayiseh RB, Mbah GE, Lustigman S, Makepeace BL, Graham-Brown J, Bah GS, Okah-Nnane NH, Bayang N, Tangwa B, Ekale DD, Tanya VN. Co-Administration of Adjuvanted Recombinant Ov-103 and Ov-RAL-2 Vaccines Confer Protection against Natural Challenge in A Bovine Onchocerca ochengi Infection Model of Human Onchocerciasis. Vaccines (Basel). 2022 May 27; 10(6). PMID: 35746469; PMCID: PMC9229719.
      Citations:    
    42. Zhan B, Bottazzi ME, Hotez PJ, Lustigman S. Advancing a Human Onchocerciasis Vaccine From Antigen Discovery to Efficacy Studies Against Natural Infection of Cattle With Onchocerca ochengi. Front Cell Infect Microbiol. 2022; 12:869039. PMID: 35444961; PMCID: PMC9015098.
      Citations:    Fields:    Translation:HumansAnimals
    43. Rawal K, Sinha R, Nath SK, Preeti P, Kumari P, Gupta S, Sharma T, Strych U, Hotez P, Bottazzi ME. Vaxi-DL: A web-based deep learning server to identify potential vaccine candidates. Comput Biol Med. 2022 06; 145:105401. PMID: 35381451.
      Citations: 1     Fields:    Translation:Animals
    44. Pollet J, Strych U, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, Thimmiraju SR, Lopez B, Gillespie PM, Ronca S, Kimata JT, Reers M, Paradkar V, Hotez P, Bottazzi ME. Receptor-binding domain recombinant protein on alum-CpG induces broad protection against SARS-CoV-2 variants of concern. bioRxiv. 2022 Mar 22. PMID: 34268512; PMCID: PMC8282101.
      Citations: 1     
    45. Bartsch SM, O'Shea KJ, Chin KL, Strych U, Ferguson MC, Bottazzi ME, Wedlock PT, Cox SN, Siegmund SS, Hotez PJ, Lee BY. Maintaining face mask use before and after achieving different COVID-19 vaccination coverage levels: a modelling study. Lancet Public Health. 2022 04; 7(4):e356-e365. PMID: 35276093; PMCID: PMC8903840.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    46. Kaplan J, Centeno FH, Hayon J, Bottazzi ME, Hotez PJ, Weatherhead JE, Clark E, Woc-Colburn L. Reviewing a Decade of Outpatient Tropical Medicine in Houston, Texas. Am J Trop Med Hyg. 2022 Apr 06; 106(4):1049-1056. PMID: 35226869; PMCID: PMC8991353.
      Citations:    Fields:    
    47. Hardy L, Bottazzi ME, Coelho C, Gallo G, Campos C, W?rtele M. Biochemical Screening of Potent Zika Virus Protease Inhibitors. ChemMedChem. 2022 04 20; 17(8):e202100695. PMID: 35104396.
      Citations:    Fields:    Translation:HumansCells
    48. Wei J, Hegde VL, Yanamandra AV, O'Hara MP, Keegan B, Jones KM, Strych U, Bottazzi ME, Zhan B, Sastry KJ, Hotez PJ. Mucosal Vaccination With Recombinant Tm-WAP49 Protein Induces Protective Humoral and Cellular Immunity Against Experimental Trichuriasis in AKR Mice. Front Immunol. 2022; 13:800295. PMID: 35197976; PMCID: PMC8859434.
      Citations:    Fields:    Translation:AnimalsCellsPHPublic Health
    49. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Cavazzoni CB, Brook B, Barman S, Chen J, Diray-Arce J, Doss-Gollin S, De Leon M, Prevost-Reilly A, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Sage PT, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. An aluminum hydroxide:CpG adjuvant enhances protection elicited by a SARS-CoV-2 receptor binding domain vaccine in aged mice. Sci Transl Med. 2022 Jan 26; 14(629):eabj5305. PMID: 34783582; PMCID: PMC10176044.
      Citations: 6     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    50. Nogueira DS, Coqueiro-Dos-Santos A, Carvalho SAP, Kraemer L, Fraga VG, Santos FV, de Castro JC, Russo RC, Bottazzi ME, Hotez PJ, Zhan B, Bartholomeu DC, Bueno LL, Fujiwara RT, Gazzinelli-Guimar?es AC, Amorim CCO, Oliveira FMS, Barbosa FS, Akamatsu MA, Ho PL. ASCVac-1, a Multi-Peptide Chimeric Vaccine, Protects Mice Against Ascaris suum Infection. Front Immunol. 2021; 12:788185. PMID: 34992603; PMCID: PMC8724438.
      Citations:    Fields:    Translation:HumansAnimalsCells
    51. Wu Y, Li E, Knight M, Adeniyi-Ipadeola G, Song LZ, Burns AR, Gazzinelli-Guimaraes AC, Fujiwara R, Bottazzi ME, Weatherhead JE. Transient Ascaris suum larval migration induces intractable chronic pulmonary disease and anemia in mice. PLoS Negl Trop Dis. 2021 12; 15(12):e0010050. PMID: 34914687; PMCID: PMC8717995.
      Citations: 1     Fields:    Translation:HumansAnimals
    52. Hotez P, Amor YB, Kim JH, Kaslow D, Lall B, Ergonul O, Figueroa JP, Gursel M, Hassanain M, Kang G, Larson H, Naniche D, Sheahan T, Wilder-Smith A, Shoham S, Sow SO, Yadav P, Strub-Wourgaft N, Loveday SJ, Hannay E, Bottazzi ME, Batista C. The silent and dangerous inequity around access to COVID-19 testing: A call to action. EClinicalMedicine. 2022 Jan; 43:101230. PMID: 34927038; PMCID: PMC8668028.
      Citations: 2     
    53. Pearson MS, Tedla BA, Mekonnen GG, Proietti C, Becker L, Nakajima R, Jasinskas A, Doolan DL, Amoah AS, Knopp S, Rollinson D, Ali SM, Kabole F, Hokke CH, Adegnika AA, Field MA, van Dam G, Corstjens PLAM, Mduluza T, Mutapi F, Oeuvray C, Greco B, Chaiyadet S, Laha T, Cai P, McManus DP, Bottazzi ME, Felgner PL, Sotillo J, Loukas A. Immunomics-guided discovery of serum and urine antibodies for diagnosing urogenital schistosomiasis: a biomarker identification study. Lancet Microbe. 2021 Nov; 2(11):e617-e626. PMID: 34977830; PMCID: PMC8683377.
      Citations: 3     Translation:HumansAnimals
    54. Coler R, Reed SG, Valenzuela JG, Kamhawi S, Oliveira F, Fichera E, Glueck R, Bottazzi ME, Gupta G, Fern?ndez L, Solana JC, S?nchez C, Jim?nez M?, Requena JM, Cecilio P, P?rez-Cabezas B, Cordeiro-da-Silva A, Gradoni L, Carrillo E, Moreno J. Protective Efficacy in a Hamster Model of a Multivalent Vaccine for Human Visceral Leishmaniasis (MuLeVaClin) Consisting of the KMP11, LEISH-F3+, and LJL143 Antigens in Virosomes, Plus GLA-SE Adjuvant. Microorganisms. 2021 Oct 29; 9(11). PMID: 34835379; PMCID: PMC8618729.
      Citations: 2     
    55. Chen WH, Pollet J, Strych U, Lee J, Liu Z, Kundu RT, Versteeg L, Villar MJ, Adhikari R, Wei J, Poveda C, Keegan B, Bailey AO, Chen YL, Gillespie PM, Kimata JT, Zhan B, Hotez PJ, Bottazzi ME. Yeast-expressed recombinant SARS-CoV-2 receptor binding domain RBD203-N1 as a COVID-19 protein vaccine candidate. Protein Expr Purif. 2022 02; 190:106003. PMID: 34688919; PMCID: PMC8529586.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    56. Torres AG, Bottazzi ME, Wormley FL. Diversity, Equity, and Inclusion in the Microbial Sciences-the Texas Perspective. mBio. 2021 10 26; 12(5):e0262021. PMID: 34663093; PMCID: PMC8524335.
      Citations:    Fields:    Translation:Humans
    57. Hotez PJ, Bottazzi ME. Whole Inactivated Virus and Protein-Based COVID-19 Vaccines. Annu Rev Med. 2022 01 27; 73:55-64. PMID: 34637324.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    58. Sonnet F, Stam KA, Labuda LA, Diemert DJ, van Leeuwen R, Bottazzi ME, Hotez PJ, Bethony JM, Jochems SP, Yazdanbakhsh M, Mouwenda YD, Betouke Ongwe ME, De Vries S, Grobusch MP, Zinsou FJ, Honkpehedji YJ, Dejon Agobe JC, Kremsner PG, Adegnika AA, Massinga Loembe M. Characterization of T cell responses to co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in healthy adults in Gabon. PLoS Negl Trop Dis. 2021 10; 15(10):e0009732. PMID: 34597297; PMCID: PMC8486127.
      Citations: 1     Fields:    Translation:HumansAnimalsCellsPHPublic HealthCTClinical Trials
    59. Bartsch SM, Wedlock PT, O'Shea KJ, Cox SN, Strych U, Nuzzo JB, Ferguson MC, Bottazzi ME, Siegmund SS, Hotez PJ, Lee BY. Lives and Costs Saved by Expanding and Expediting Coronavirus Disease 2019 Vaccination. J Infect Dis. 2021 09 17; 224(6):938-948. PMID: 33954775; PMCID: PMC8136017.
      Citations: 11     Fields:    Translation:HumansCellsPHPublic Health
    60. Figueroa JP, Hotez PJ, Ben Amor Y, Ergonul O, Gilbert S, Gursel M, Hassanain M, Kang G, Kaslow DC, Kim JH, Lall B, Larson H, Naniche D, Sheahan T, Shoham S, Wilder-Smith A, Sow SO, Strub-Wourgaft N, Yadav P, Bottazzi ME, Batista C. Achieving global equity for COVID-19 vaccines: Stronger international partnerships and greater advocacy and solidarity are needed. PLoS Med. 2021 09; 18(9):e1003772. PMID: 34516558; PMCID: PMC8475996.
      Citations: 2     Fields:    Translation:HumansCells
    61. Versteeg L, Adhikari R, Poveda C, Villar-Mondragon MJ, Jones KM, Hotez PJ, Bottazzi ME, Tijhaar E, Pollet J. Location and expression kinetics of Tc24 in different life stages of Trypanosoma cruzi. PLoS Negl Trop Dis. 2021 09; 15(9):e0009689. PMID: 34478444; PMCID: PMC8415617.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    62. Rawal K, Sinha R, Abbasi BA, Chaudhary A, Nath SK, Kumari P, Preeti P, Saraf D, Singh S, Mishra K, Gupta P, Mishra A, Sharma T, Gupta S, Singh P, Sood S, Subramani P, Dubey AK, Strych U, Hotez PJ, Bottazzi ME. Identification of vaccine targets in pathogens and design of a vaccine using computational approaches. Sci Rep. 2021 09 02; 11(1):17626. PMID: 34475453; PMCID: PMC8413327.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    63. Hoffman KA, Villar MJ, Poveda C, Bottazzi ME, Hotez PJ, Tweardy DJ, Jones KM. Signal Transducer and Activator of Transcription-3 Modulation of Cardiac Pathology in Chronic Chagasic Cardiomyopathy. Front Cell Infect Microbiol. 2021; 11:708325. PMID: 34504808; PMCID: PMC8421853.
      Citations: 1     Fields:    Translation:Animals
    64. Hotez PJ, Amor YB, Ergonul O, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kaslow DC, Kim JH, Lall B, Larson H, Naniche D, Sheahan T, Shoham S, Wilder-Smith A, Sow SO, Strub-Wourgaft N, Yadav P, Bottazzi ME, Batista C. Global public health security and justice for vaccines and therapeutics in the COVID-19 pandemic. EClinicalMedicine. 2021 Sep; 39:101053. PMID: 34368661; PMCID: PMC8330385.
      Citations: 7     
    65. Pritchard DI, Diemert D, Bottazzi ME, Hawdon JM, Bethony JM, Correa-Oliveira R. Controlled Infection of Humans with the Hookworm Parasite Necator americanus to Accelerate Vaccine Development : The Human Hookworm Vaccination/Challenge Model (HVCM). Curr Top Microbiol Immunol. 2021 Jul 31. PMID: 34328562.
      Citations: 2     Fields:    
    66. Pino M, Abid T, Pereira Ribeiro S, Edara VV, Floyd K, Smith JC, Latif MB, Pacheco-Sanchez G, Dutta D, Wang S, Gumber S, Kirejczyk S, Cohen J, Stammen RL, Jean SM, Wood JS, Connor-Stroud F, Pollet J, Chen WH, Wei J, Zhan B, Lee J, Liu Z, Strych U, Shenvi N, Easley K, Weiskopf D, Sette A, Pollara J, Mielke D, Gao H, Eisel N, LaBranche CC, Shen X, Ferrari G, Tomaras GD, Montefiori DC, Sekaly RP, Vanderford TH, Tomai MA, Fox CB, Suthar MS, Kozlowski PA, Hotez PJ, Paiardini M, Bottazzi ME, Kasturi SP. A yeast expressed RBD-based SARS-CoV-2 vaccine formulated with 3M-052-alum adjuvant promotes protective efficacy in non-human primates. Sci Immunol. 2021 07 15; 6(61). PMID: 34266981; PMCID: PMC9119307.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    67. Li G, Hoeweler L, Keegan B, Peng J, Scholte L, Hotez P, Bottazzi ME, Diemert D, Bethony J. Potency testing for a recombinant protein vaccine early in clinical development: Lessons from the Schistosoma mansoni Tetraspanin 2 vaccine. Vaccine X. 2021 Aug; 8:100100. PMID: 34169270; PMCID: PMC8209742.
      Citations:    
    68. Naniche D, Hotez P, Bottazzi ME, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kaslow D, Kim JH, Lall B, Larson H, Sheahan T, Shoham S, Wilder-Smith A, Sow SO, Strub-Wourgaft N, Yadav P, Ergonul O, Batista C. Beyond the jab: A need for global coordination of pharmacovigilance for COVID-19 vaccine deployment. EClinicalMedicine. 2021 Jun; 36:100925. PMID: 34099998; PMCID: PMC8173024.
      Citations: 4     
    69. Shoham S, Ergonul O, Hotez P, Bottazzi ME, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kaslow D, Kim JH, Lall B, Larson H, Naniche D, Sheahan T, Wilder-Smith A, Sow SO, Yadav P, Strub-Wourgaft N, Batista C. Urgent needs to accelerate the race for COVID-19 therapeutics. EClinicalMedicine. 2021 Jun; 36:100911. PMID: 34036254; PMCID: PMC8141354.
      Citations: 1     
    70. Nanishi E, Borriello F, O'Meara TR, McGrath ME, Saito Y, Haupt RE, Seo HS, van Haren SD, Brook B, Chen J, Diray-Arce J, Doss-Gollin S, Leon M, Chew K, Menon M, Song K, Xu AZ, Caradonna TM, Feldman J, Hauser BM, Schmidt AG, Sherman AC, Baden LR, Ernst RK, Dillen C, Weston SM, Johnson RM, Hammond HL, Mayer R, Burke A, Bottazzi ME, Hotez PJ, Strych U, Chang A, Yu J, Barouch DH, Dhe-Paganon S, Zanoni I, Ozonoff A, Frieman MB, Levy O, Dowling DJ. Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity. bioRxiv. 2021 May 21. PMID: 34031655; PMCID: PMC8142652.
      Citations: 1     
    71. Lee J, Liu Z, Chen WH, Wei J, Kundu R, Adhikari R, Rivera JA, Gillespie PM, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Process development and scale-up optimization of the SARS-CoV-2 receptor binding domain-based vaccine candidate, RBD219-N1C1. Appl Microbiol Biotechnol. 2021 May; 105(10):4153-4165. PMID: 33959781; PMCID: PMC8102132.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    72. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Altieri Rivera J, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A yeast-expressed SARS-CoV-2 recombinant receptor-binding domain candidate vaccine stimulates virus neutralizing antibodies and T-cell immunity in mice. Hum Vaccin Immunother. 2021 08 03; 17(8):2356-2366. PMID: 33847226; PMCID: PMC8054496.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    73. Hoffman K, Liu Z, Hossain E, Bottazzi ME, Hotez PJ, Jones KM, McCall LI. Alterations to the Cardiac Metabolome Induced by Chronic T. cruzi Infection Relate to the Degree of Cardiac Pathology. ACS Infect Dis. 2021 06 11; 7(6):1638-1649. PMID: 33843195; PMCID: PMC8588157.
      Citations: 5     Fields:    Translation:HumansAnimals
    74. Hayon J, Weatherhead J, Hotez PJ, Bottazzi ME, Zhan B. Advances in vaccine development for human trichuriasis. Parasitology. 2021 Mar 24; 1-12. PMID: 33757603.
      Citations: 3     Fields:    
    75. Chen WH, Wei J, Kundu RT, Adhikari R, Liu Z, Lee J, Versteeg L, Poveda C, Keegan B, Villar MJ, de Araujo Leao AC, Rivera JA, Gillespie PM, Pollet J, Strych U, Zhan B, Hotez PJ, Bottazzi ME. Genetic modification to design a stable yeast-expressed recombinant SARS-CoV-2 receptor binding domain as a COVID-19 vaccine candidate. Biochim Biophys Acta Gen Subj. 2021 06; 1865(6):129893. PMID: 33731300; PMCID: PMC7955913.
      Citations: 10     Fields:    Translation:AnimalsCells
    76. Hotez P, Ergonul O, Figueroa JP, Gilbert S, Gursel M, Hassanain M, Kang G, Kim JH, Lall B, Larson H, Naniche D, Sheahan T, Shoham S, Wilder-Smith A, Strub-Wourgaft N, Yadav P, Bottazzi ME, Batista C. Correcting COVID-19 vaccine misinformation: Lancet Commission on COVID-19 Vaccines and Therapeutics Task Force Members. EClinicalMedicine. 2021 Mar; 33:100780. PMID: 33718854; PMCID: PMC7935671.
      Citations: 16     
    77. Messenger LA, Lewis MD, Yeo M, Bartholomeu DC, Gorchakov R, Jones K, Nolan MS, Bottazzi ME, Hotez PJ, Murray KO, Burleigh B, Miles MA, Talavera-L?pez C, Reis-Cunha JL, Matos GM, Calzada JE, Salda?a A, Ram?rez JD, Guhl F, Oca?a-Mayorga S, Costales JA, Teixeira SMR, Carrasco HJ, Grijalva MJ, Grisard EC, Andersson B. Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen,?Trypanosoma cruzi. Front Cell Infect Microbiol. 2021; 11:614665. PMID: 33747978; PMCID: PMC7966520.
      Citations: 11     Fields:    Translation:Animals
    78. Pollet J, Chen WH, Versteeg L, Keegan B, Zhan B, Wei J, Liu Z, Lee J, Kundu R, Adhikari R, Poveda C, Villar MJ, de Araujo Leao AC, Rivera JA, Momin Z, Gillespie PM, Kimata JT, Strych U, Hotez PJ, Bottazzi ME. SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice. bioRxiv. 2021 Feb 09. PMID: 33173864; PMCID: PMC7654852.
      Citations: 3     
    79. Cruz-Chan JV, Villanueva-Lizama LE, Versteeg L, Damania A, Keegan B, Pollet J, Gusovsky F, Hotez PJ, Bottazzi ME, Jones KM, Villar MJ, Gonz?lez-L?pez C. Vaccine-linked chemotherapy induces IL-17 production and reduces cardiac pathology during acute Trypanosoma cruzi infection. Sci Rep. 2021 02 05; 11(1):3222. PMID: 33547365; PMCID: PMC7865072.
      Citations: 4     Fields:    Translation:Animals
    80. Ryan NM, Hess JA, de Villena FP, Leiby BE, Shimada A, Yu L, Yarmahmoodi A, Petrovsky N, Zhan B, Bottazzi ME, Makepeace BL, Lustigman S, Abraham D. Onchocerca volvulus bivalent subunit vaccine induces protective immunity in genetically diverse collaborative cross recombinant inbred intercross mice. NPJ Vaccines. 2021 Jan 26; 6(1):17. PMID: 33500417; PMCID: PMC7838260.
      Citations: 4     
    81. Bartsch SM, O'Shea KJ, Wedlock PT, Strych U, Ferguson MC, Bottazzi ME, Randall SL, Siegmund SS, Cox SN, Hotez PJ, Lee BY. The Benefits of Vaccinating With the First Available COVID-19 Coronavirus Vaccine. Am J Prev Med. 2021 05; 60(5):605-613. PMID: 33632650; PMCID: PMC7817395.
      Citations: 7     Fields:    Translation:HumansPHPublic Health
    82. Clark EH, Fredricks K, Woc-Colburn L, Bottazzi ME, Weatherhead J. Preparing for SARS-CoV-2 Vaccines in US Immigrant Communities: Strategies for Allocation, Distribution, and Communication. Am J Public Health. 2021 Apr; 111(4):577-581. PMID: 33351664; PMCID: PMC7958074.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    83. Hotez PJ, Huete-Perez JA, Bottazzi ME. COVID-19 in the Americas and the erosion of human rights for the poor. PLoS Negl Trop Dis. 2020 12; 14(12):e0008954. PMID: 33338042; PMCID: PMC7748132.
      Citations: 4     Fields:    Translation:HumansCellsPHPublic Health
    84. Zhan B, Bottazzi ME, Hotez PJ, de Castro JC, de Almeida LV, Cardoso MS, Oliveira FMS, Nogueira DS, Reis-Cunha JL, Magalhaes LMD, Bueno LL, Bartholomeu DC, Fujiwara RT. Vaccination with chimeric protein induces protection in murine model against ascariasis. Vaccine. 2021 01 08; 39(2):394-401. PMID: 33248854.
      Citations: 3     Fields:    Translation:AnimalsPHPublic Health
    85. Poveda C, Bottazzi ME, Jones KM. Mining the Metabolome for New and Innovative Chagas Disease Treatments. Trends Pharmacol Sci. 2021 01; 42(1):1-3. PMID: 33248705.
      Citations: 1     Fields:    Translation:HumansAnimals
    86. Weatherhead JE, Gazzinelli-Guimaraes P, Knight JM, Fujiwara R, Hotez PJ, Bottazzi ME, Corry DB. Host Immunity and Inflammation to Pulmonary Helminth Infections. Front Immunol. 2020; 11:594520. PMID: 33193446; PMCID: PMC7606285.
      Citations: 10     Fields:    Translation:HumansAnimals
    87. Hotez P, Bottazzi ME, Strub-Wourgaft N, Sosa-Estani S, Torrico F, Abril M, Sancho J, Paj?n L. A new patient registry for Chagas disease. PLoS Negl Trop Dis. 2020 10; 14(10):e0008418. PMID: 33001966; PMCID: PMC7529299.
      Citations: 4     Fields:    Translation:HumansAnimals
    88. Chen WH, Tao X, Agrawal AS, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-expressed SARS-CoV recombinant receptor-binding domain (RBD219-N1) formulated with aluminum hydroxide induces protective immunity and reduces immune enhancement. Vaccine. 2020 11 03; 38(47):7533-7541. PMID: 33039209; PMCID: PMC7508514.
      Citations: 38     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    89. van Leeuwen R, Molemans M, Yazdanbakhsh M, Hotez PJ, Bottazzi ME, Li G, Bethony JM, Diemert DJ, HookVac Consortium, Adegnika AA, de Vries SG, Zinsou FJ, Honkepehedji YJ, Dejon Agob? JC, Vodonou KG, Bikangui R, Bouyoukou Hounkpatin A, Bache EB, Massinga Loembe M, Kremsner PG, Grobusch MP. Safety and immunogenicity of co-administered hookworm vaccine candidates Na-GST-1 and Na-APR-1 in Gabonese adults: a randomised, controlled, double-blind, phase 1 dose-escalation trial. Lancet Infect Dis. 2021 02; 21(2):275-285. PMID: 32926834.
      Citations: 7     Fields:    Translation:HumansAnimalsCTClinical Trials
    90. Liu Z, Kundu R, Biter AB, Nyon MP, Chen WH, Zhan B, Strych U, Hotez PJ, Bottazzi ME, Damena S. A scalable and reproducible manufacturing process for Phlebotomus papatasi salivary protein PpSP15, a vaccine candidate for leishmaniasis. Protein Expr Purif. 2021 01; 177:105750. PMID: 32920041.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    91. Mejia R, Hotez P, Bottazzi ME. Global COVID-19 Efforts as the Platform to Achieving the Sustainable Development Goals. Curr Trop Med Rep. 2020; 7(4):99-103. PMID: 32844081; PMCID: PMC7440684.
      Citations: 11     
    92. Diemert DJ, Valente V, Fraga CG, Talles F, Grahek S, Campbell D, Jariwala A, Periago MV, Enk M, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Correa-Oliveira R, Hotez P, Bethony J, Freire J, Gazzinelli MF. Correction: Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. PLoS Negl Trop Dis. 2020 08; 14(8):e0008670. PMID: 32804987; PMCID: PMC7430704.
      Citations:    Fields:    
    93. Hotez PJ, Bottazzi ME. Developing a low-cost and accessible COVID-19 vaccine for global health. PLoS Negl Trop Dis. 2020 07; 14(7):e0008548. PMID: 32726304; PMCID: PMC7390283.
      Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    94. Mekonnen GG, Tedla BA, Pickering D, Becker L, Wang L, Zhan B, Bottazzi ME, Loukas A, Sotillo J, Pearson MS. Schistosoma haematobium Extracellular Vesicle Proteins Confer Protection in a Heterologous Model of Schistosomiasis. Vaccines (Basel). 2020 Jul 24; 8(3). PMID: 32722279; PMCID: PMC7563238.
      Citations: 14     
    95. Bartsch SM, O'Shea KJ, Ferguson MC, Bottazzi ME, Wedlock PT, Strych U, McKinnell JA, Siegmund SS, Cox SN, Hotez PJ, Lee BY. Vaccine Efficacy Needed for a COVID-19 Coronavirus Vaccine to Prevent or Stop an Epidemic as the Sole Intervention. Am J Prev Med. 2020 10; 59(4):493-503. PMID: 32778354; PMCID: PMC7361120.
      Citations: 110     Fields:    Translation:HumansCellsPHPublic Health
    96. Clark E, Fredricks K, Woc-Colburn L, Bottazzi ME, Weatherhead J. Disproportionate impact of the COVID-19 pandemic on immigrant communities in the United States. PLoS Negl Trop Dis. 2020 07; 14(7):e0008484. PMID: 32658925; PMCID: PMC7357736.
      Citations: 69     Fields:    Translation:HumansCellsPHPublic Health
    97. Villanueva-Lizama LE, Cruz-Chan JV, Versteeg L, Hoffman K, Kendricks A, Keegan B, Pollet J, Gusovsky F, Hotez PJ, Bottazzi ME, Jones KM, Teh-Poot CF. TLR4 agonist protects against Trypanosoma cruzi acute lethal infection by decreasing cardiac parasite burdens. Parasite Immunol. 2020 10; 42(10):e12769. PMID: 32592180.
      Citations: 7     Fields:    Translation:Animals
    98. Chen WH, Tao X, Agrawal A, Algaissi A, Peng BH, Pollet J, Strych U, Bottazzi ME, Hotez PJ, Lustigman S, Du L, Jiang S, Tseng CK. Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement. bioRxiv. 2020 Jul 05. PMID: 32511385; PMCID: PMC7263514.
      Citations:    
    99. Hotez PJ, Corry DB, Strych U, Bottazzi ME. COVID-19 vaccines: neutralizing antibodies and the alum advantage. Nat Rev Immunol. 2020 07; 20(7):399-400. PMID: 32499636; PMCID: PMC7271131.
      Citations: 36     Fields:    Translation:HumansAnimals
    100. Bottazzi ME, Strych U, Hotez PJ, Corry DB. Coronavirus vaccine-associated lung immunopathology-what is the significance? Microbes Infect. 2020 10; 22(9):403-404. PMID: 32599077; PMCID: PMC7318931.
      Citations: 9     Fields:    Translation:HumansCellsPHPublic Health
    101. Bottazzi ME. I Never Thought I Had "Moral Courage," until COVID-19 Happened. Am J Trop Med Hyg. 2020 08; 103(2):551. PMID: 32588797; PMCID: PMC7410466.
      Citations:    Fields:    Translation:HumansCellsPHPublic Health
    102. Naceanceno KS, Bottazzi ME, Sanchez A, Mejia R, Matamoros G, Gabrie JA. Use of Multi-Parallel Real-Time Quantitative PCR to Determine Blastocystis Prevalence and Association with Other Gastrointestinal Parasite Infection in a Rural Honduran Location. Am J Trop Med Hyg. 2020 06; 102(6):1373-1375. PMID: 32189609; PMCID: PMC7253141.
      Citations: 3     Fields:    Translation:HumansAnimals
    103. Bartsch SM, O'Shea KJ, Ferguson MC, Bottazzi ME, Cox SN, Strych U, McKinnell JA, Wedlock PT, Siegmund SS, Hotez PJ, Lee BY. How Efficacious Must a COVID-19 Coronavirus Vaccine be to Prevent or Stop an Epidemic by Itself. medRxiv. 2020 May 30. PMID: 32511569; PMCID: PMC7274250.
      Citations:    
    104. Dumonteil E, Herrera C, Tu W, Goff K, Fahlberg M, Haupt E, Kaur A, Marx PA, Hotez PJ, Bottazzi ME, Ortega-Lopez J. Safety and immunogenicity of a recombinant vaccine against Trypanosoma cruzi in Rhesus macaques. Vaccine. 2020 06 15; 38(29):4584-4591. PMID: 32417142; PMCID: PMC7310587.
      Citations: 5     Fields:    Translation:AnimalsCells
    105. Hotez PJ, Corry DB, Bottazzi ME. COVID-19 vaccine design: the Janus face of immune enhancement. Nat Rev Immunol. 2020 06; 20(6):347-348. PMID: 32346094; PMCID: PMC7187801.
      Citations: 78     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    106. Marcinkiewicz AL, Lieknina I, Yang X, Lederman PL, Hart TM, Yates J, Chen WH, Bottazzi ME, Mantis NJ, Kraiczy P, Pal U, Tars K, Lin YP. The Factor H-Binding Site of CspZ as a Protective Target against Multistrain, Tick-Transmitted Lyme Disease. Infect Immun. 2020 04 20; 88(5). PMID: 32122944; PMCID: PMC7171238.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    107. Hotez PJ, Bottazzi ME, Corry DB. The potential role of Th17 immune responses in coronavirus immunopathology and vaccine-induced immune enhancement. Microbes Infect. 2020 May - Jun; 22(4-5):165-167. PMID: 32305501; PMCID: PMC7162764.
      Citations: 52     Fields:    Translation:HumansCellsPHPublic Health
    108. Chen WH, Hotez PJ, Bottazzi ME. Potential for developing a SARS-CoV receptor-binding domain (RBD) recombinant protein as a heterologous human vaccine against coronavirus infectious disease (COVID)-19. Hum Vaccin Immunother. 2020 06 02; 16(6):1239-1242. PMID: 32298218; PMCID: PMC7482854.
      Citations: 53     Fields:    Translation:HumansCellsPHPublic Health
    109. Hotez PJ, Bottazzi ME, Singh SK, Brindley PJ, Kamhawi S. Will COVID-19 become the next neglected tropical disease? PLoS Negl Trop Dis. 2020 04; 14(4):e0008271. PMID: 32275667; PMCID: PMC7147803.
      Citations: 10     Fields:    Translation:HumansCellsPHPublic Health
    110. Hotez PJ, Damania A, Bottazzi ME. Central Latin America: Two decades of challenges in neglected tropical disease control. PLoS Negl Trop Dis. 2020 03; 14(3):e0007962. PMID: 32214311; PMCID: PMC7098567.
      Citations: 10     Fields:    Translation:HumansPHPublic Health
    111. Kendricks AL, Gray SB, Wilkerson GK, Sands CM, Abee CR, Bernacky BJ, Hotez PJ, Bottazzi ME, Craig SL, Jones KM. Reproductive Outcomes in Rhesus Macaques (Macaca mulatta) with Naturally-acquired Trypanosoma cruzi Infection. Comp Med. 2020 04 01; 70(2):152-159. PMID: 32183928; PMCID: PMC7137543.
      Citations:    Fields:    Translation:Animals
    112. Bartsch SM, Stokes-Cawley OJ, Buekens P, Asti L, Bottazzi ME, Strych U, Wedlock PT, Mitgang EA, Meymandi S, Hotez PJ, Lee BY, Falcon-Lezama JA. The potential economic value of a therapeutic Chagas disease vaccine for pregnant women to prevent congenital transmission. Vaccine. 2020 04 03; 38(16):3261-3270. PMID: 32171575; PMCID: PMC9009251.
      Citations: 3     Fields:    Translation:HumansPHPublic Health
    113. Chen WH, Strych U, Hotez PJ, Bottazzi ME. The SARS-CoV-2 Vaccine Pipeline: an Overview. Curr Trop Med Rep. 2020; 7(2):61-64. PMID: 32219057; PMCID: PMC7094941.
      Citations: 215     
    114. Chen WH, Nyon MP, Poongavanam MV, Liu Z, Biter AB, Kundu RT, Strych U, Hotez PJ, Bottazzi ME. Process Characterization and Biophysical Analysis for a Yeast-Expressed Phlebotomus papatasi Salivary Protein (PpSP15) as?a Leishmania Vaccine Candidate. J Pharm Sci. 2020 05; 109(5):1673-1680. PMID: 32070701; PMCID: PMC7125844.
      Citations: 1     Fields:    Translation:Animals
    115. Versteeg L, Wei J, Liu Z, Keegan B, Fujiwara RT, Jones KM, Asojo O, Strych U, Bottazzi ME, Hotez PJ, Zhan B. Protective immunity elicited by the nematode-conserved As37 recombinant protein against Ascaris suum infection. PLoS Negl Trop Dis. 2020 02; 14(2):e0008057. PMID: 32053593; PMCID: PMC7017989.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    116. Bartsch SM, Asti L, Stokes-Cawley OJ, Sim SY, Bottazzi ME, Hotez PJ, Lee BY. The Potential Economic Value of a Zika Vaccine for a Woman of Childbearing Age. Am J Prev Med. 2020 03; 58(3):370-377. PMID: 31980305.
      Citations:    Fields:    Translation:HumansPHPublic Health
    117. Hoffman KA, Reynolds C, Bottazzi ME, Hotez P, Jones K. Improved Biomarker and Imaging Analysis for Characterizing Progressive Cardiac Fibrosis in a Mouse Model of Chronic Chagasic Cardiomyopathy. J Am Heart Assoc. 2019 11 19; 8(22):e013365. PMID: 31718442; PMCID: PMC6915297.
      Citations: 5     Fields:    Translation:AnimalsCells
    118. Bottazzi ME. Inspiring women scientists in Honduras. EBioMedicine. 2019 Nov; 49:21. PMID: 31636013; PMCID: PMC6945274.
      Citations: 1     Fields:    Translation:Humans
    119. Poveda C, Biter AB, Bottazzi ME, Strych U. Establishing Preferred Product Characterization for the Evaluation of RNA Vaccine Antigens. Vaccines (Basel). 2019 Sep 27; 7(4). PMID: 31569760; PMCID: PMC6963847.
      Citations: 8     
    120. Biter AB, Pollet J, Chen WH, Strych U, Hotez PJ, Bottazzi ME. A method to probe protein structure from UV absorbance spectra. Anal Biochem. 2019 12 15; 587:113450. PMID: 31550438.
      Citations:    Fields:    Translation:Cells
    121. George PJ, Hess JA, Jain S, Patton JB, Zhan T, Tricoche N, Zhan B, Bottazzi ME, Hotez PJ, Abraham D, Lustigman S. Antibody responses against the vaccine antigens Ov-103 and Ov-RAL-2 are associated with protective immunity to Onchocerca volvulus infection in both mice and humans. PLoS Negl Trop Dis. 2019 09; 13(9):e0007730. PMID: 31525197; PMCID: PMC6762197.
      Citations: 5     Fields:    Translation:AnimalsCellsPHPublic Health
    122. Keitel WA, Potter GE, Diemert D, Bethony J, El Sahly HM, Kennedy JK, Patel SM, Plieskatt JL, Jones W, Deye G, Bottazzi ME, Hotez PJ, Atmar RL. A phase 1 study of the safety, reactogenicity, and immunogenicity of a Schistosoma mansoni vaccine with or without glucopyranosyl lipid A aqueous formulation (GLA-AF) in healthy adults from a non-endemic area. Vaccine. 2019 10 08; 37(43):6500-6509. PMID: 31515141; PMCID: PMC6771426.
      Citations: 16     Fields:    Translation:HumansAnimalsCTClinical Trials
    123. Barreira F, Hotez PJ, Alonso-Padilla J, Cort?s-Serra N, Pinazo MJ, Bottazzi ME, Abril M, Sosa-Estani S, Gasc?n J. Response to `letter to the editor: 'Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America'?. Expert Rev Anti Infect Ther. 2019 09; 17(9):673-675. PMID: 31361163.
      Citations: 1     Fields:    Translation:Humans
    124. Bottazzi ME, Hotez PJ. "Running the Gauntlet": Formidable challenges in advancing neglected tropical diseases vaccines from development through licensure, and a "Call to Action". Hum Vaccin Immunother. 2019; 15(10):2235-2242. PMID: 31180271; PMCID: PMC6816440.
      Citations: 7     Fields:    Translation:HumansPHPublic Health
    125. Barry MA, Versteeg L, Wang Q, Pollet J, Zhan B, Gusovsky F, Bottazzi ME, Hotez PJ, Jones KM. A therapeutic vaccine prototype induces protective immunity and reduces cardiac fibrosis in a mouse model of chronic Trypanosoma cruzi infection. PLoS Negl Trop Dis. 2019 05; 13(5):e0007413. PMID: 31145733; PMCID: PMC6542517.
      Citations: 19     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    126. Bartsch SM, Bottazzi ME, Asti L, Strych U, Meymandi S, Randall S, Hotez PJ, Lee BY, Falc?n-Lezama JA. Economic value of a therapeutic Chagas vaccine for indeterminate and Chagasic cardiomyopathy patients. Vaccine. 2019 06 19; 37(28):3704-3714. PMID: 31104883.
      Citations: 5     Fields:    Translation:HumansAnimalsPHPublic Health
    127. Barreira F, Hotez PJ, Alonso-Padilla J, Cort?s-Serra N, Pinazo MJ, Bottazzi ME, Abril M, Sosa-Estani S, Gasc?n J. Strategies to enhance access to diagnosis and treatment for Chagas disease patients in Latin America. Expert Rev Anti Infect Ther. 2019 03; 17(3):145-157. PMID: 30712412.
      Citations: 26     Fields:    Translation:HumansAnimals
    128. Wang L, Zou Y, Zhu X, Bottazzi ME, Hotez PJ, Zhan B. China's shifting neglected parasitic infections in an era of economic reform, urbanization, disease control, and the Belt and Road Initiative. PLoS Negl Trop Dis. 2019 01; 13(1):e0006946. PMID: 30677027; PMCID: PMC6345419.
      Citations: 4     Fields:    Translation:HumansPHPublic Health
    129. Weatherhead JE, Porter P, Coffey A, Haydel D, Versteeg L, Zhan B, Fujiwara R, Jaramillo AM, Bottazzi ME, Hotez PJ, Corry DB, Beaumier CM, Gazzinelli Guimar?es AC. Ascaris Larval Infection and Lung Invasion Directly Induce Severe Allergic Airway Disease in Mice. Infect Immun. 2018 12; 86(12). PMID: 30249744; PMCID: PMC6246907.
      Citations: 15     Fields:    Translation:AnimalsCells
    130. Hotez PJ, Bottazzi ME, Bethony J, Diemert DD. Advancing the Development of a Human Schistosomiasis Vaccine. Trends Parasitol. 2019 02; 35(2):104-108. PMID: 30455112.
      Citations: 17     Fields:    Translation:Humans
    131. Jones KM, Weatherhead J, Bottazzi ME, Hotez PJ, Zhan B, Gazzinelli-Guimar?es AC, Gazzinelli-Guimar?es PH, Nogueira DS, Oliveira FMS, Barbosa FS, Amorim CCO, Cardoso MS, Kraemer L, Caliari MV, Akamatsu MA, Ho PL, Bartholomeu DC, Russo RC, Bueno LL, Fujiwara RT. IgG Induced by Vaccination With Ascaris suum Extracts Is Protective Against Infection. Front Immunol. 2018; 9:2535. PMID: 30473693; PMCID: PMC6238660.
      Citations: 17     Fields:    Translation:AnimalsPHPublic Health
    132. Zhan B, Arumugam S, Kennedy MW, Tricoche N, Lian LY, Asojo OA, Bennuru S, Bottazzi ME, Hotez PJ, Lustigman S, Klei TR. Ligand binding properties of two Brugia malayi fatty acid and retinol (FAR) binding proteins and their vaccine efficacies against challenge infection in gerbils. PLoS Negl Trop Dis. 2018 10; 12(10):e0006772. PMID: 30296268; PMCID: PMC6193737.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    133. Gunter SM, Versteeg L, Jones KM, Keegan BP, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Covalent vaccination with Trypanosoma cruzi Tc24 induces catalytic antibody production. Parasite Immunol. 2018 Nov; 40(11):e12585. PMID: 30132929.
      Citations: 3     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    134. Gillespie P, Zhan B, Bottazzi ME, Hotez PJ, Dumonteil E, de la Cruz JJ, Villanueva-Lizama L, Dzul-Huchim V, Ram?rez-Sierra MJ, Martinez-Vega P, Rosado-Vallado M, Ortega-Lopez J, Flores-Pucheta CI. Production of recombinant TSA-1 and evaluation of its potential for the immuno-therapeutic control of Trypanosoma cruzi infection in mice. Hum Vaccin Immunother. 2019; 15(1):210-219. PMID: 30192702; PMCID: PMC6363145.
      Citations: 11     Fields:    Translation:AnimalsCells
    135. Briggs N, Wei J, Versteeg L, Zhan B, Keegan B, Damania A, Pollet J, Hayes KS, Beaumier C, Seid CA, Leong J, Grencis RK, Bottazzi ME, Sastry KJ, Hotez PJ. Trichuris muris whey acidic protein induces type 2 protective immunity against whipworm. PLoS Pathog. 2018 08; 14(8):e1007273. PMID: 30153307; PMCID: PMC6130879.
      Citations: 10     Fields:    Translation:AnimalsPHPublic Health
    136. Diemert DJ, Bottazzi ME, Plieskatt J, Hotez PJ, Bethony JM. Lessons along the Critical Path: Developing Vaccines against Human Helminths. Trends Parasitol. 2018 09; 34(9):747-758. PMID: 30064902.
      Citations: 18     Fields:    Translation:Humans
    137. Jain S, George PJ, Deng W, Koussa J, Parkhouse K, Hensley SE, Jiang J, Lu J, Liu Z, Wei J, Zhan B, Bottazzi ME, Shen H, Lustigman S. The parasite-derived rOv-ASP-1 is an effective antigen-sparing CD4+ T cell-dependent adjuvant for the trivalent inactivated influenza vaccine, and functions in the absence of MyD88 pathway. Vaccine. 2018 06 14; 36(25):3650-3665. PMID: 29764680; PMCID: PMC6595497.
      Citations: 3     Fields:    Translation:AnimalsCellsPHPublic Health
    138. Diemert D, Campbell D, Brelsford J, Leasure C, Li G, Peng J, Zumer M, Younes N, Bottazzi ME, Mejia R, Pritchard DI, Hawdon JM, Bethony JM. Controlled Human Hookworm Infection: Accelerating Human Hookworm Vaccine Development. Open Forum Infect Dis. 2018 May; 5(5):ofy083. PMID: 29780848; PMCID: PMC5952933.
      Citations: 13     
    139. Jones K, Versteeg L, Damania A, Keegan B, Kendricks A, Pollet J, Cruz-Chan JV, Gusovsky F, Hotez PJ, Bottazzi ME. Vaccine-Linked Chemotherapy Improves Benznidazole Efficacy for Acute Chagas Disease. Infect Immun. 2018 04; 86(4). PMID: 29311242; PMCID: PMC5865041.
      Citations: 16     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    140. Bouchery T, Filbey K, Shepherd A, Chandler J, Patel D, Schmidt A, Camberis M, Peignier A, Smith AAT, Johnston K, Painter G, Pearson M, Giacomin P, Loukas A, Bottazzi ME, Hotez P, LeGros G. A novel blood-feeding detoxification pathway in Nippostrongylus brasiliensis L3 reveals a potential checkpoint for arresting hookworm development. PLoS Pathog. 2018 03; 14(3):e1006931. PMID: 29566094; PMCID: PMC5864084.
      Citations: 10     Fields:    Translation:AnimalsCells
    141. Nyon MP, Du L, Tseng CK, Seid CA, Pollet J, Naceanceno KS, Agrawal A, Algaissi A, Peng BH, Tai W, Jiang S, Bottazzi ME, Strych U, Hotez PJ. Engineering a stable CHO cell line for the expression of a MERS-coronavirus vaccine antigen. Vaccine. 2018 03 27; 36(14):1853-1862. PMID: 29496347; PMCID: PMC5860679.
      Citations: 34     Fields:    Translation:AnimalsCells
    142. Jones K, Hotez P, Bottazzi ME, Villanueva-Lizama LE, Cruz-Chan JV, Aguilar-Cetina ADC, Herrera-Sanchez LF, Rodriguez-Perez JM, Rosado-Vallado ME, Ramirez-Sierra MJ, Ortega-Lopez J, Dumonteil E. Trypanosoma cruzi vaccine candidate antigens Tc24 and TSA-1 recall memory immune response associated with HLA-A and -B supertypes in Chagasic chronic patients from Mexico. PLoS Negl Trop Dis. 2018 01; 12(1):e0006240. PMID: 29377898; PMCID: PMC5805372.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    143. Biter AB, Weltje S, Hudspeth EM, Seid CA, McAtee CP, Chen WH, Pollet JB, Strych U, Hotez PJ, Bottazzi ME. Characterization and Stability of Trypanosoma cruzi 24-C4 (Tc24-C4), a Candidate Antigen for a Therapeutic Vaccine Against Chagas Disease. J Pharm Sci. 2018 05; 107(5):1468-1473. PMID: 29274820.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    144. McKenna ML, McAtee S, Bryan PE, Jeun R, Ward T, Kraus J, Bottazzi ME, Hotez PJ, Flowers CC, Mejia R. Human Intestinal Parasite Burden and Poor Sanitation in Rural Alabama. Am J Trop Med Hyg. 2017 Nov; 97(5):1623-1628. PMID: 29016326; PMCID: PMC5817782.
      Citations: 35     Fields:    Translation:HumansAnimalsPHPublic Health
    145. Lustigman S, Makepeace BL, Klei TR, Babayan SA, Hotez P, Abraham D, Bottazzi ME. Onchocerca volvulus: The Road from Basic Biology to a Vaccine. Trends Parasitol. 2018 01; 34(1):64-79. PMID: 28958602; PMCID: PMC5748257.
      Citations: 17     Fields:    Translation:HumansAnimals
    146. Konduri V, Halpert MM, Liang D, Levitt JM, Cruz-Chan JV, Zhan B, Bottazzi ME, Hotez PJ, Jones KM, Decker WK. Genetic Adjuvantation of a Cell-Based Therapeutic Vaccine for Amelioration of Chagasic Cardiomyopathy. Infect Immun. 2017 09; 85(9). PMID: 28674032; PMCID: PMC5563592.
      Citations: 7     Fields:    Translation:AnimalsCells
    147. Liu Z, Kelleher A, Tabb S, Wei J, Pollet J, Hotez PJ, Bottazzi ME, Zhan B, Asojo OA. Identification, Characterization, and Structure of Tm16 from Trichuris muris. J Parasitol Res. 2017; 2017:4342789. PMID: 28884022; PMCID: PMC5573103.
      Citations: 3     
    148. Wei J, Versteeg L, Liu Z, Keegan B, Fujiwara RT, Briggs N, Jones KM, Strych U, Beaumier CM, Bottazzi ME, Hotez PJ, Zhan B, Gazzinelli-Guimar?es AC. Yeast-expressed recombinant As16 protects mice against Ascaris suum infection through induction of a Th2-skewed immune response. PLoS Negl Trop Dis. 2017 Jul; 11(7):e0005769. PMID: 28708895; PMCID: PMC5529013.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    149. Gunter SM, Jones KM, Seid CA, Essigmann HT, Zhan B, Strych U, Bottazzi ME, Hotez PJ, Brown EL. Mutations to Cysteine Residues in the Trypanosoma cruzi B-Cell Superantigen Tc24 Diminish Susceptibility to IgM-Mediated Hydrolysis. J Parasitol. 2017 10; 103(5):579-583. PMID: 28581897.
      Citations: 2     Fields:    Translation:AnimalsCellsPHPublic Health
    150. Diemert DJ, Grahek S, Campbell D, Jariwala A, Bottazzi ME, Hamilton R, Brelsford J, Yakovleva A, Li G, Peng J, Hotez P, Bethony J, Freire J, Valente V, Fraga CG, Talles F, Periago MV, Enk M, Gazzinelli MF, Correa-Oliveira R. Safety and immunogenicity of the Na-GST-1 hookworm vaccine in Brazilian and American adults. PLoS Negl Trop Dis. 2017 05; 11(5):e0005574. PMID: 28464026; PMCID: PMC5441635.
      Citations: 25     Fields:    Translation:HumansAnimalsCTClinical Trials
    151. Chen WH, Chag SM, Poongavanam MV, Biter AB, Ewere EA, Rezende W, Seid CA, Hudspeth EM, Pollet J, McAtee CP, Strych U, Bottazzi ME, Hotez PJ. Optimization of the Production Process and Characterization of the Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1), a SARS Vaccine Candidate. J Pharm Sci. 2017 08; 106(8):1961-1970. PMID: 28456726; PMCID: PMC5612335.
      Citations: 36     Fields:    Translation:HumansAnimalsCells
    152. Asojo OA, Kelleher A, Liu Z, Pollet J, Hudspeth EM, Rezende WC, Groen MJ, Seid CA, Abdeladhim M, Townsend S, de Castro W, Mendes-Sousa A, Bottazzi ME, Hotez PJ, Zhan B, Oliveira F, Kamhawi S, Valenzuela JG, Bartholomeu DC, Fujiwara RT. Structure of SALO, a leishmaniasis vaccine candidate from the sand fly Lutzomyia longipalpis. PLoS Negl Trop Dis. 2017 03; 11(3):e0005374. PMID: 28278244; PMCID: PMC5344329.
      Citations: 3     Fields:    Translation:AnimalsCells
    153. Brelsford JB, Plieskatt JL, Yakovleva A, Jariwala A, Keegan BP, Peng J, Xia P, Li G, Campbell D, Bottazzi ME, Hotez PJ, Diemert D, Bethony JM, Periago MV, Correa-Oliveira R. Advances in neglected tropical disease vaccines: Developing relative potency and functional assays for the Na-GST-1/Alhydrogel hookworm vaccine. PLoS Negl Trop Dis. 2017 02; 11(2):e0005385. PMID: 28192438; PMCID: PMC5325600.
      Citations: 6     Fields:    Translation:HumansAnimals
    154. Pollet J, Versteeg L, Rezende W, Strych U, Gusovsky F, Hotez PJ, Bottazzi ME. A simple fluorescence-based assay for quantification of the Toll-Like Receptor agonist E6020 in vaccine formulations. Vaccine. 2017 03 07; 35(10):1410-1416. PMID: 28190745.
      Citations:    Fields:    Translation:Humans
    155. McAtee CP, Seid CA, Hammond M, Hudspeth E, Keegan BP, Liu Z, Wei J, Zhan B, Hotez PJ, Bottazzi ME, Arjona-Sabido R, Cruz-Chan V, Dumonteil E. Expression, purification, immunogenicity and protective efficacy of a recombinant nucleoside hydrolase from Leishmania donovani, a vaccine candidate for preventing cutaneous leishmaniasis. Protein Expr Purif. 2017 02; 130:129-136. PMID: 27773761.
      Citations: 5     Fields:    Translation:Animals
    156. Seid CA, Jones KM, Pollet J, Keegan B, Hudspeth E, Hammond M, Wei J, McAtee CP, Versteeg L, Gutierrez A, Liu Z, Zhan B, Respress JL, Strych U, Bottazzi ME, Hotez PJ. Cysteine mutagenesis improves the production without abrogating antigenicity of a recombinant protein vaccine candidate for human chagas disease. Hum Vaccin Immunother. 2017 03 04; 13(3):621-633. PMID: 27737611; PMCID: PMC5360114.
      Citations: 15     Fields:    Translation:AnimalsCells
    157. Wei J, Damania A, Gao X, Liu Z, Mejia R, Mitreva M, Strych U, Bottazzi ME, Hotez PJ, Zhan B. The hookworm Ancylostoma ceylanicum intestinal transcriptome provides a platform for selecting drug and vaccine candidates. Parasit Vectors. 2016 Sep 27; 9(1):518. PMID: 27677574; PMCID: PMC5039805.
      Citations: 10     Fields:    
    158. Bartsch SM, Hotez PJ, Asti L, Zapf KM, Bottazzi ME, Diemert DJ, Lee BY. The Global Economic and Health Burden of Human Hookworm Infection. PLoS Negl Trop Dis. 2016 09; 10(9):e0004922. PMID: 27607360; PMCID: PMC5015833.
      Citations: 52     Fields:    Translation:Humans
    159. Hess JA, Zhan B, Torigian AR, Patton JB, Petrovsky N, Zhan T, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D. The Immunomodulatory Role of Adjuvants in Vaccines Formulated with the Recombinant Antigens Ov-103 and Ov-RAL-2 against Onchocerca volvulus in Mice. PLoS Negl Trop Dis. 2016 07; 10(7):e0004797. PMID: 27387453; PMCID: PMC4936747.
      Citations: 13     Fields:    Translation:HumansAnimalsPHPublic Health
    160. Hotez PJ, Strych U, Lustigman S, Bottazzi ME. Human anthelminthic vaccines: Rationale and challenges. Vaccine. 2016 06 24; 34(30):3549-55. PMID: 27171753.
      Citations: 18     Fields:    Translation:Humans
    161. Arumugam S, Wei J, Liu Z, Abraham D, Bell A, Bottazzi ME, Hotez PJ, Zhan B, Lustigman S, Klei TR. Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection. PLoS Negl Trop Dis. 2016 Apr; 10(4):e0004586. PMID: 27045170; PMCID: PMC4821550.
      Citations: 14     Fields:    Translation:Animals
    162. Hotez PJ, Beaumier CM, Gillespie PM, Strych U, Hayward T, Bottazzi ME. Advancing a vaccine to prevent hookworm disease and anemia. Vaccine. 2016 06 03; 34(26):3001-3005. PMID: 27040400.
      Citations: 18     Fields:    Translation:HumansAnimals
    163. Merrifield M, Hotez PJ, Beaumier CM, Gillespie P, Strych U, Hayward T, Bottazzi ME. Advancing a vaccine to prevent human schistosomiasis. Vaccine. 2016 06 03; 34(26):2988-2991. PMID: 27036511.
      Citations: 45     Fields:    Translation:HumansAnimals
    164. Beaumier CM, Gillespie PM, Strych U, Hayward T, Hotez PJ, Bottazzi ME. Status of vaccine research and development of vaccines for Chagas disease. Vaccine. 2016 06 03; 34(26):2996-3000. PMID: 27026146.
      Citations: 25     Fields:    Translation:Humans
    165. Bartsch SM, Hotez PJ, Hertenstein DL, Diemert DJ, Zapf KM, Bottazzi ME, Bethony JM, Brown ST, Lee BY. Modeling the economic and epidemiologic impact of hookworm vaccine and mass drug administration (MDA) in Brazil, a high transmission setting. Vaccine. 2016 Apr 27; 34(19):2197-206. PMID: 27002501; PMCID: PMC5547742.
      Citations: 15     Fields:    Translation:HumansPHPublic Health
    166. Gillespie PM, Beaumier CM, Strych U, Hayward T, Hotez PJ, Bottazzi ME. Status of vaccine research and development of vaccines for leishmaniasis. Vaccine. 2016 06 03; 34(26):2992-2995. PMID: 26973063.
      Citations: 59     Fields:    Translation:HumansAnimals
    167. Pecoul B, Batista C, Stobbaerts E, Ribeiro I, Vilasanjuan R, Gascon J, Pinazo MJ, Moriana S, Gold S, Pereiro A, Navarro M, Torrico F, Bottazzi ME, Hotez PJ. The BENEFIT Trial: Where Do We Go from Here? PLoS Negl Trop Dis. 2016 Feb; 10(2):e0004343. PMID: 26913759; PMCID: PMC4767872.
      Citations: 48     Fields:    Translation:HumansAnimals
    168. Barry MA, Wang Q, Jones KM, Heffernan MJ, Buhaya MH, Beaumier CM, Keegan BP, Zhan B, Bottazzi ME, Hotez PJ, Dumonteil E. A therapeutic nanoparticle vaccine against Trypanosoma cruzi in a BALB/c mouse model of Chagas disease. Hum Vaccin Immunother. 2016 04 02; 12(4):976-87. PMID: 26890466; PMCID: PMC4962947.
      Citations: 25     Fields:    Translation:AnimalsCells
    169. Hudspeth EM, Wang Q, Seid CA, Hammond M, Wei J, Liu Z, Zhan B, Pollet J, Heffernan MJ, McAtee CP, Engler DA, Strych U, Asojo OA, Hotez PJ, Bottazzi ME, Matsunami RK. Expression and purification of an engineered, yeast-expressed Leishmania donovani nucleoside hydrolase with immunogenic properties. Hum Vaccin Immunother. 2016 07 02; 12(7):1707-20. PMID: 26839079; PMCID: PMC4964838.
      Citations: 5     Fields:    Translation:AnimalsCells
    170. Gunter SM, Jones KM, Zhan B, Essigmann HT, Murray KO, Garcia MN, Gorchakov R, Bottazzi ME, Hotez PJ, Brown EL. Identification and Characterization of the Trypanosoma cruzi B-cell Superantigen Tc24. Am J Trop Med Hyg. 2016 Jan; 94(1):114-121. PMID: 26598565; PMCID: PMC4710414.
      Citations: 4     Fields:    Translation:HumansAnimals
    171. Zhan B, Ajmera R, Geiger SM, Liu Z, Wei J, Wilkins PP, Fujiwara R, Gazzinelli-Guimaraes PH, Bottazzi ME, Hotez P, Gon?alves MT. Identification of immunodominant antigens for the laboratory diagnosis of toxocariasis. Trop Med Int Health. 2015 Dec; 20(12):1787-96. PMID: 26426162.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    172. Hotez PJ, Bottazzi ME, Strych U. New Vaccines for the World's Poorest People. Annu Rev Med. 2016; 67:405-17. PMID: 26356803.
      Citations: 20     Fields:    Translation:Humans
    173. Seid CA, Hudspeth EM, Wei J, Liu Z, Kwityn C, Hammond M, Zhan B, Hotez PJ, Bottazzi ME, Martinez-Campos V, Martinez-Vega P, Ramirez-Sierra MJ, Rosado-Vallado M, Ortega-L?pez J, Dumonteil E. Expression, purification, immunogenicity, and protective efficacy of a recombinant Tc24 antigen as a vaccine against Trypanosoma cruzi infection in mice. Vaccine. 2015 Aug 26; 33(36):4505-12. PMID: 26192358.
      Citations: 19     Fields:    Translation:AnimalsCells
    174. Hotez PJ, Bottazzi ME, Strych U, Chang LY, Lim YA, Goodenow MM, AbuBakar S. Neglected tropical diseases among the Association of Southeast Asian Nations (ASEAN): overview and update. PLoS Negl Trop Dis. 2015 Apr; 9(4):e0003575. PMID: 25880767; PMCID: PMC4400050.
      Citations: 42     Fields:    Translation:HumansAnimalsPHPublic Health
    175. Bottazzi ME. The human hookworm vaccine: recent updates and prospects for success. J Helminthol. 2015 Sep; 89(5):540-4. PMID: 25850789; PMCID: PMC4531467.
      Citations: 7     Fields:    Translation:HumansAnimalsPHPublic Health
    176. Hotez PJ, Bottazzi ME, Buekens P, Dumonteil E. The Gulf of Mexico: a "hot zone" for neglected tropical diseases? PLoS Negl Trop Dis. 2015 Feb; 9(2):e0003481. PMID: 25719411; PMCID: PMC4342336.
      Citations: 2     Fields:    
    177. Hotez PJ, Bottazzi ME, Zhan B, Makepeace BL, Klei TR, Abraham D, Taylor DW, Lustigman S. The Onchocerciasis Vaccine for Africa--TOVA--Initiative. PLoS Negl Trop Dis. 2015 Jan; 9(1):e0003422. PMID: 25634641; PMCID: PMC4310604.
      Citations: 16     Fields:    
    178. Seid CA, Curti E, Jones RM, Hudspeth E, Rezende W, Pollet J, Center L, Versteeg L, Pritchard S, Musiychuk K, Yusibov V, Hotez PJ, Bottazzi ME. Expression, purification, and characterization of the Necator americanus aspartic protease-1 (Na-APR-1 (M74)) antigen, a component of the bivalent human hookworm vaccine. Hum Vaccin Immunother. 2015; 11(6):1474-88. PMID: 25905574; PMCID: PMC4514214.
      Citations: 9     Fields:    Translation:Animals
    179. Pearson MS, Jariwala AR, Abbenante G, Plieskatt J, Wilson D, Bottazzi ME, Hotez PJ, Keegan B, Bethony JM, Loukas A. New tools for NTD vaccines: A case study of quality control assays for product development of the human hookworm vaccine Na-APR-1M74. Hum Vaccin Immunother. 2015; 11(5):1251-7. PMID: 26018444; PMCID: PMC4514234.
      Citations: 5     Fields:    Translation:Animals
    180. Knight JM, Zingales B, Bottazzi ME, Hotez P, Zhan B. Limited antigenic variation in the Trypanosoma cruzi candidate vaccine antigen TSA-1. Parasite Immunol. 2014 Dec; 36(12):708-12. PMID: 25040249.
      Citations: 3     Fields:    Translation:HumansAnimals
    181. Garcia MN, Murray KO, Hotez PJ, Rossmann SN, Gorchakov R, Ontiveros A, Woc-Colburn L, Bottazzi ME, Rhodes CE, Ballantyne CM, Aguilar D. Development of chagas cardiac manifestations among Texas blood donors. Am J Cardiol. 2015 Jan 01; 115(1):113-7. PMID: 25456877.
      Citations: 13     Fields:    Translation:Humans
    182. Garcia MN, Woc-Colburn L, Rossmann SN, Townsend RL, Stramer SL, Bravo M, Kamel H, Beddard R, Townsend M, Oldham R, Bottazzi ME, Hotez PJ, Murray KO. Trypanosoma cruzi screening in Texas blood donors, 2008-2012. Epidemiol Infect. 2016 Apr; 144(5):1010-3. PMID: 25170765.
      Citations: 12     Fields:    Translation:HumansAnimalsPHPublic Health
    183. Lee RM, Moore LB, Bottazzi ME, Hotez PJ. Toxocariasis in North America: a systematic review. PLoS Negl Trop Dis. 2014 Aug; 8(8):e3116. PMID: 25166906; PMCID: PMC4148222.
      Citations: 32     Fields:    Translation:Humans
    184. Hotez PJ, Bottazzi ME, Tseng CT, Zhan B, Lustigman S, Du L, Jiang S. Calling for rapid development of a safe and effective MERS vaccine. Microbes Infect. 2014 Jul; 16(7):529-31. PMID: 24931059; PMCID: PMC7128618.
      Citations: 21     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    185. Hess JA, Zhan B, Deckman JM, Bottazzi ME, Hotez PJ, Klei TR, Lustigman S, Abraham D, Bonne-Ann?e S. Vaccines to combat river blindness: expression, selection and formulation of vaccines against infection with Onchocerca volvulus in a mouse model. Int J Parasitol. 2014 Aug; 44(9):637-46. PMID: 24907553; PMCID: PMC4118642.
      Citations: 17     Fields:    Translation:Animals
    186. Hotez PJ, Woc-Colburn L, Bottazzi ME. Neglected tropical diseases in Central America and Panama: review of their prevalence, populations at risk and impact on regional development. Int J Parasitol. 2014 Aug; 44(9):597-603. PMID: 24846528.
      Citations: 28     Fields:    Translation:Humans
    187. Sanchez AL, Mejia RE, Bottazzi ME, Canales M, Gabrie JA, Rueda MM. A scoping review and prevalence analysis of soil-transmitted helminth infections in Honduras. PLoS Negl Trop Dis. 2014; 8(1):e2653. PMID: 24466359; PMCID: PMC3900402.
      Citations: 7     Fields:    Translation:HumansAnimals
    188. Zhan B, Beaumier CM, Briggs N, Jones KM, Keegan BP, Bottazzi ME, Hotez PJ. Advancing a multivalent 'Pan-anthelmintic' vaccine against soil-transmitted nematode infections. Expert Rev Vaccines. 2014 Mar; 13(3):321-31. PMID: 24392641; PMCID: PMC3934375.
      Citations: 25     Fields:    Translation:HumansAnimals
    189. Bottazzi ME. Vaccines against neglected tropical diseases: promising interventions to rescue the poorest populations in the Americas. Immunotherapy. 2014; 6(2):117-9. PMID: 24491084.
      Citations: 3     Fields:    Translation:PHPublic Health
    190. Curti E, Seid CA, Hudspeth E, Center L, Rezende W, Pollet J, Kwityn C, Hammond M, Matsunami RK, Engler DA, Hotez PJ, Elena Bottazzi M. Optimization and revision of the production process of the Necator americanus glutathione S-transferase 1 (Na-GST-1), the lead hookworm vaccine recombinant protein candidate. Hum Vaccin Immunother. 2014; 10(7):1914-25. PMID: 25424799; PMCID: PMC4186034.
      Citations: 11     Fields:    Translation:HumansAnimals
    191. BOTTAZZI M, Murray KO, Hotez PJ. . Los Estados Unidos de America: Pais endemico o no endemico de la enfermedad de Chagas. Revista española de salud pública. 2014; 1(88).
    192. BOTTAZZI M, Mejia R. . Current tropical medicine reports: A path forward to highlight research and clinical advances, new trends and innovations. Current Tropical Medicine Reports. 2014; (1):1.
    193. Chen WH, Du L, Chag SM, Ma C, Tricoche N, Tao X, Seid CA, Hudspeth EM, Lustigman S, Tseng CT, Bottazzi ME, Hotez PJ, Zhan B, Jiang S. Yeast-expressed recombinant protein of the receptor-binding domain in SARS-CoV spike protein with deglycosylated forms as a SARS vaccine candidate. Hum Vaccin Immunother. 2014; 10(3):648-58. PMID: 24355931; PMCID: PMC4130269.
      Citations: 57     Fields:    Translation:AnimalsCells
    194. Hotez PJ, Dumonteil E, Betancourt Cravioto M, Bottazzi ME, Tapia-Conyer R, Meymandi S, Karunakara U, Ribeiro I, Cohen RM, Pecoul B. An unfolding tragedy of Chagas disease in North America. PLoS Negl Trop Dis. 2013; 7(10):e2300. PMID: 24205411; PMCID: PMC3814410.
      Citations: 49     Fields:    Translation:HumansAnimals
    195. Sanchez AL, Canales M, Enriquez L, Bottazzi ME, Zelaya AA, Espinoza VE, Fontecha GA. A research capacity strengthening project for infectious diseases in Honduras: experience and lessons learned. Glob Health Action. 2013 Aug 07; 6:21643. PMID: 23930937; PMCID: PMC3739968.
      Citations: 2     Fields:    Translation:HumansPHPublic Health
    196. Curti E, Kwityn C, Zhan B, Gillespie P, Brelsford J, Deumic V, Plieskatt J, Rezende WC, Tsao E, Kalampanayil B, Hotez PJ, Bottazzi ME. Expression at a 20L scale and purification of the extracellular domain of the Schistosoma mansoni TSP-2 recombinant protein: a vaccine candidate for human intestinal schistosomiasis. Hum Vaccin Immunother. 2013 Nov; 9(11):2342-50. PMID: 23899507; PMCID: PMC3981843.
      Citations: 13     Fields:    Translation:Animals
    197. Cheng W, Curti E, Rezende WC, Kwityn C, Zhan B, Gillespie P, Plieskatt J, Joshi SB, Volkin DB, Hotez PJ, Middaugh CR, Bottazzi ME. Biophysical and formulation studies of the Schistosoma mansoni TSP-2 extracellular domain recombinant protein, a lead vaccine candidate antigen for intestinal schistosomiasis. Hum Vaccin Immunother. 2013 Nov; 9(11):2351-61. PMID: 23880663; PMCID: PMC3981844.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    198. Andrus J, Bottazzi ME, Chow J, Goraleski KA, Fisher-Hoch SP, Lambuth JK, Lee BY, Margolis HS, McCormick JB, Melby P, Murray KO, Rico-Hesse R, Valenzuela JG, Hotez PJ. Ears of the Armadillo: Global Health Research and Neglected Diseases in Texas. PLoS Negl Trop Dis. 2013 Jun; 7(6):e2021. PMID: 23826397; PMCID: PMC3694818.
      Citations: 9     Fields:    
    199. Hotez PJ, Diemert D, Bacon KM, Beaumier C, Bethony JM, Bottazzi ME, Brooker S, Couto AR, Freire Mda S, Homma A, Lee BY, Loukas A, Loblack M, Morel CM, Oliveira RC, Russell PK. The Human Hookworm Vaccine. Vaccine. 2013 Apr 18; 31 Suppl 2:B227-32. PMID: 23598487; PMCID: PMC3988917.
      Citations: 39     Fields:    Translation:HumansAnimals
    200. Beaumier CM, Gillespie PM, Hotez PJ, Bottazzi ME. New vaccines for neglected parasitic diseases and dengue. Transl Res. 2013 Sep; 162(3):144-55. PMID: 23578479.
      Citations: 58     Fields:    Translation:Humans
    201. Lee BY, Bacon KM, Bottazzi ME, Hotez PJ. Global economic burden of Chagas disease: a computational simulation model. Lancet Infect Dis. 2013 Apr; 13(4):342-8. PMID: 23395248; PMCID: PMC3763184.
      Citations: 224     Fields:    Translation:Humans
    202. Hotez PJ, Dumonteil E, Heffernan MJ, Bottazzi ME. Innovation for the 'bottom 100 million': eliminating neglected tropical diseases in the Americas. Adv Exp Med Biol. 2013; 764:1-12. PMID: 23654053.
      Citations: 18     Fields:    Translation:HumansPHPublic Health
    203. Jiang S, Bottazzi ME, Du L, Lustigman S, Tseng CT, Curti E, Jones K, Zhan B, Hotez PJ. Roadmap to developing a recombinant coronavirus S protein receptor-binding domain vaccine for severe acute respiratory syndrome. Expert Rev Vaccines. 2012 Dec; 11(12):1405-13. PMID: 23252385; PMCID: PMC3586247.
      Citations: 68     Fields:    Translation:HumansAnimalsCells
    204. Bacon KM, Hotez PJ, Kruchten SD, Kamhawi S, Bottazzi ME, Valenzuela JG, Lee BY. The potential economic value of a cutaneous leishmaniasis vaccine in seven endemic countries in the Americas. Vaccine. 2013 Jan 07; 31(3):480-6. PMID: 23176979; PMCID: PMC3763201.
      Citations: 21     Fields:    Translation:HumansPHPublic Health
    205. Bottazzi ME, Zhan B, Heffernan MJ, Jones K, Valenzuela JG, Kamhawi S, Lee BY, Bacon KM, Fleischer B, Slingsby BT, Cravioto MB, Tapia-Conyer R, Hotez PJ, Dumonteil E, Ortega J, de Leon Rosales SP. Accelerating the development of a therapeutic vaccine for human Chagas disease: rationale and prospects. Expert Rev Vaccines. 2012 Sep; 11(9):1043-55. PMID: 23151163; PMCID: PMC3819810.
      Citations: 47     Fields:    Translation:HumansAnimalsPHPublic Health
    206. Lee BY, Bacon KM, Wateska AR, Bottazzi ME, Dumonteil E, Hotez PJ. Modeling the economic value of a Chagas' disease therapeutic vaccine. Hum Vaccin Immunother. 2012 Sep; 8(9):1293-301. PMID: 22894964; PMCID: PMC3579910.
      Citations: 28     Fields:    Translation:Humans
    207. Zhan B, Santiago H, Keegan B, Gillespie P, Xue J, Bethony J, de Oliveira LM, Jiang D, Diemert D, Xiao SH, Jones K, Feng X, Hotez PJ, Bottazzi ME. Fusion of Na-ASP-2 with human immunoglobulin Fc? abrogates histamine release from basophils sensitized with anti-Na-ASP-2 IgE. Parasite Immunol. 2012 Aug-Sep; 34(8-9):404-11. PMID: 22651670.
      Citations: 7     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    208. Hotez PJ, Dumonteil E, Woc-Colburn L, Serpa JA, Bezek S, Edwards MS, Hallmark CJ, Musselwhite LW, Flink BJ, Bottazzi ME. Chagas disease: "the new HIV/AIDS of the Americas". PLoS Negl Trop Dis. 2012; 6(5):e1498. PMID: 22666504; PMCID: PMC3362306.
      Citations: 85     Fields:    Translation:HumansPHPublic Health
    209. Plieskatt JL, Rezende WC, Olsen CM, Trefethen JM, Joshi SB, Middaugh CR, Hotez PJ, Bottazzi ME. Advances in vaccines against neglected tropical diseases: enhancing physical stability of a recombinant hookworm vaccine through biophysical and formulation studies. Hum Vaccin Immunother. 2012 Jun; 8(6):765-76. PMID: 22495115.
      Citations: 9     Fields:    Translation:HumansAnimals
    210. Goud GN, Deumic V, Gupta R, Brelsford J, Zhan B, Gillespie P, Plieskatt JL, Tsao EI, Hotez PJ, Bottazzi ME. Expression, purification, and molecular analysis of the Necator americanus glutathione S-transferase 1 (Na-GST-1): a production process developed for a lead candidate recombinant hookworm vaccine antigen. Protein Expr Purif. 2012 Jun; 83(2):145-51. PMID: 22503665.
      Citations: 13     Fields:    Translation:Animals
    211. Hotez PJ, Bottazzi ME, Dumonteil E, Valenzuela JG, Kamhawi S, Ortega J, Rosales SP, Cravioto MB, Tapia-Conyer R. Texas and Mexico: sharing a legacy of poverty and neglected tropical diseases. PLoS Negl Trop Dis. 2012; 6(3):e1497. PMID: 22479656; PMCID: PMC3313919.
      Citations: 22     Fields:    Translation:HumansPHPublic Health
    212. Mathias DK, Plieskatt JL, Armistead JS, Bethony JM, Abdul-Majid KB, McMillan A, Angov E, Aryee MJ, Zhan B, Gillespie P, Keegan B, Jariwala AR, Rezende W, Bottazzi ME, Scorpio DG, Hotez PJ, Dinglasan RR. Expression, immunogenicity, histopathology, and potency of a mosquito-based malaria transmission-blocking recombinant vaccine. Infect Immun. 2012 Apr; 80(4):1606-14. PMID: 22311924; PMCID: PMC3318422.
      Citations: 26     Fields:    Translation:HumansAnimalsPHPublic Health
    213. Lustigman S, McKerrow JH, BOTTAZZI M. . Parasitic Helminths. 1st Edition ed. Caffrey CR, editor. Weinheim, Germany: Wiley-Blackwell. Chapter 22, Vaccines Linked to Chemotherapy: A new approach to control helminth infections. 2012; 357.
    214. Bottazzi M, Della Torre L. [Immigration, work and health--social, cultural and best practices in occupational medicine: the views of union patronage]. G Ital Med Lav Ergon. 2011 Apr-Jun; 33(2 Suppl):29-32. PMID: 22187920.
      Citations: 1     Fields:    Translation:Humans
    215. Jiang D, Zhan B, Mayor RS, Gillespie P, Keegan B, Bottazzi ME, Hotez P. Ac-AP-12, a novel factor Xa anticoagulant peptide from the esophageal glands of adult Ancylostoma caninum. Mol Biochem Parasitol. 2011 May; 177(1):42-8. PMID: 21251931.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    216. BOTTAZZI M, Dumonteil E, Valenzuela J, Betancourt-Cravioto M, Tapia-Conyer R, et al. . Bridging the innovation gap for neglected tropical diseases in Mexico: Capacity building for the development of a new generation of antipoverty vaccines. B. oletin Medico del Hospital Infantil de Mexico. 2011; (2):130.
    217. Zhan B, Bottazzi ME, Perez OA, Koski RA, Asojo OA, Bonaf? N. Expression, purification, crystallization and preliminary X-ray analysis of a truncated soluble domain of human glioma pathogenesis-related protein 1. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2010 Nov 01; 66(Pt 11):1487-9. PMID: 21045302; PMCID: PMC3001655.
      Citations: 3     Fields:    Translation:HumansCells
    218. Jariwala AR, Oliveira LM, Diemert DJ, Keegan B, Plieskatt JL, Periago MV, Bottazzi ME, Hotez PJ, Bethony JM. Potency testing for the experimental Na-GST-1 hookworm vaccine. Expert Rev Vaccines. 2010 Oct; 9(10):1219-30. PMID: 20923271.
      Citations: 11     Fields:    Translation:HumansAnimals
    219. Zhan B, Perally S, Brophy PM, Xue J, Goud G, Liu S, Deumic V, de Oliveira LM, Bethony J, Bottazzi ME, Jiang D, Gillespie P, Xiao SH, Gupta R, Loukas A, Ranjit N, Lustigman S, Oksov Y, Hotez P. Molecular cloning, biochemical characterization, and partial protective immunity of the heme-binding glutathione S-transferases from the human hookworm Necator americanus. Infect Immun. 2010 Apr; 78(4):1552-63. PMID: 20145100; PMCID: PMC2849424.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    220. Bethony JM, BOTTAZZI M, Brown A, Diemert D, Loukas A, et al. . New Generation Vaccines. 4th ed. Levine MM, editor. New York: Informa Helathcare USA. Chapter 75, Hookworm Vaccines. 2010; 830.
    221. Cai S, He F, Samra HS, de la Maza LM, Bottazzi ME, Joshi SB, Middaugh CR. Biophysical and stabilization studies of the Chlamydia trachomatis mouse pneumonitis major outer membrane protein. Mol Pharm. 2009 Sep-Oct; 6(5):1553-61. PMID: 19650664; PMCID: PMC2757499.
      Citations: 7     Fields:    Translation:AnimalsCells
    222. Bottazzi ME, Hotez PJ, Franco-Paredes C. The unfinished public health agenda of chagas disease in the era of globalization. PLoS Negl Trop Dis. 2009 Jul 07; 3(7):e470. PMID: 19582139; PMCID: PMC2700253.
      Citations: 6     Fields:    Translation:HumansPHPublic Health
    223. Pearson MS, Bethony JM, Pickering DA, de Oliveira LM, Jariwala A, Santiago H, Miles AP, Zhan B, Jiang D, Ranjit N, Mulvenna J, Tribolet L, Plieskatt J, Smith T, Bottazzi ME, Jones K, Keegan B, Hotez PJ, Loukas A. An enzymatically inactivated hemoglobinase from Necator americanus induces neutralizing antibodies against multiple hookworm species and protects dogs against heterologous hookworm infection. FASEB J. 2009 Sep; 23(9):3007-19. PMID: 19380510; PMCID: PMC2735369.
      Citations: 30     Fields:    Translation:HumansAnimalsPHPublic Health
    224. Bottazzi ME, Brown AS. Model for product development of vaccines against neglected tropical diseases: a vaccine against human hookworm. Expert Rev Vaccines. 2008 Dec; 7(10):1481-92. PMID: 19053205.
      Citations: 3     Fields:    Translation:HumansAnimals
    225. Hotez PJ, Bottazzi ME, Franco-Paredes C, Ault SK, Periago MR. The neglected tropical diseases of Latin America and the Caribbean: a review of disease burden and distribution and a roadmap for control and elimination. PLoS Negl Trop Dis. 2008 Sep 24; 2(9):e300. PMID: 18820747; PMCID: PMC2553488.
      Citations: 258     Fields:    Translation:Humans
    226. Gazzinelli G, Bottazzi ME, Caldas IR, Campi-Azevedo AC, Teixeira-Carvalho A, Corr?a-Oliveira R. In vitro cultured peripheral blood mononuclear cells from patients with chronic schistosomiasis mansoni show immunomodulation of cyclin D1,2,3 in the presence of soluble egg antigens. Microbes Infect. 2007 Oct; 9(12-13):1493-9. PMID: 17913547.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    227. Kehn K, Berro R, Alhaj A, Bottazzi ME, Yeh WI, Klase Z, Van Duyne R, Fu S, Kashanchi F. Functional consequences of cyclin D1/BRCA1 interaction in breast cancer cells. Oncogene. 2007 Aug 02; 26(35):5060-9. PMID: 17334399.
      Citations: 16     Fields:    Translation:HumansCells
    228. Fujiwara RT, Zhan B, Mendez S, Loukas A, Bueno LL, Wang Y, Plieskatt J, Oksov Y, Lustigman S, Bottazzi ME, Hotez P, Bethony JM. Reduction of worm fecundity and canine host blood loss mediates protection against hookworm infection elicited by vaccination with recombinant Ac-16. Clin Vaccine Immunol. 2007 Mar; 14(3):281-7. PMID: 17267592; PMCID: PMC1828853.
      Citations: 14     Fields:    Translation:AnimalsCellsPHPublic Health
    229. Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Diemert D, Loukas A. New technologies for the control of human hookworm infection. Trends Parasitol. 2006 Jul; 22(7):327-31. PMID: 16709466.
      Citations: 26     Fields:    Translation:HumansAnimals
    230. Bottazzi ME, Miles AP, Diemert D, Hotez PJ. An ounce of prevention on a budget: a nonprofit approach to developing vaccines against neglected diseases. Expert Rev Vaccines. 2006 Apr; 5(2):189-98. PMID: 16608419.
      Citations: 7     Fields:    Translation:Humans
    231. Williamson AL, Lustigman S, Oksov Y, Deumic V, Plieskatt J, Mendez S, Zhan B, Bottazzi ME, Hotez PJ, Loukas A. Ancylostoma caninum MTP-1, an astacin-like metalloprotease secreted by infective hookworm larvae, is involved in tissue migration. Infect Immun. 2006 Feb; 74(2):961-7. PMID: 16428741; PMCID: PMC1360348.
      Citations: 42     Fields:    Translation:Animals
    232. Ghosh K, Wu W, Antoine AD, Bottazzi ME, Valenzuela JG, Hotez PJ, Mendez S. The impact of concurrent and treated Ancylostoma ceylanicum hookworm infections on the immunogenicity of a recombinant hookworm vaccine in hamsters. J Infect Dis. 2006 Jan 01; 193(1):155-62. PMID: 16323144.
      Citations: 14     Fields:    Translation:HumansAnimalsPHPublic Health
    233. Loukas A, Bethony JM, Mendez S, Fujiwara RT, Goud GN, Ranjit N, Zhan B, Jones K, Bottazzi ME, Hotez PJ. Vaccination with recombinant aspartic hemoglobinase reduces parasite load and blood loss after hookworm infection in dogs. PLoS Med. 2005 Oct; 2(10):e295. PMID: 16231975; PMCID: PMC1240050.
      Citations: 37     Fields:    Translation:AnimalsCellsPHPublic HealthCTClinical Trials
    234. Goud GN, Bottazzi ME, Zhan B, Mendez S, Deumic V, Plieskatt J, Liu S, Wang Y, Bueno L, Fujiwara R, Samuel A, Ahn SY, Solanki M, Asojo OA, Wang J, Bethony JM, Loukas A, Roy M, Hotez PJ. Expression of the Necator americanus hookworm larval antigen Na-ASP-2 in Pichia pastoris and purification of the recombinant protein for use in human clinical trials. Vaccine. 2005 Sep 15; 23(39):4754-64. PMID: 16054275.
      Citations: 33     Fields:    Translation:HumansAnimalsPHPublic Health
    235. Fujiwara RT, Loukas A, Mendez S, Williamson AL, Bueno LL, Wang Y, Samuel A, Zhan B, Bottazzi ME, Hotez PJ, Bethony JM. Vaccination with irradiated Ancylostoma caninum third stage larvae induces a Th2 protective response in dogs. Vaccine. 2006 Jan 23; 24(4):501-9. PMID: 16140437.
      Citations: 20     Fields:    Translation:AnimalsCellsPHPublic Health
    236. Bethony J, Loukas A, Smout M, Brooker S, Mendez S, Plieskatt J, Goud G, Bottazzi ME, Zhan B, Wang Y, Williamson A, Lustigman S, Correa-Oliveira R, Xiao S, Hotez PJ. Antibodies against a secreted protein from hookworm larvae reduce the intensity of hookworm infection in humans and vaccinated laboratory animals. FASEB J. 2005 Oct; 19(12):1743-5. PMID: 16037096.
      Citations: 64     Fields:    Translation:HumansAnimals
    237. Fujiwara RT, Bethony J, Bueno LL, Wang Y, Ahn SY, Samuel A, Bottazzi ME, Hotez P, Mendez S. Immunogenicity of the hookworm Na-ASP-2 vaccine candidate: characterization of humoral and cellular responses after vaccination in the Sprague Dawley rat. Hum Vaccin. 2005 May-Jun; 1(3):123-8. PMID: 17012856.
      Citations: 6     Fields:    Translation:AnimalsCells
    238. Hotez PJ, Bethony J, Bottazzi ME, Brooker S, Buss P. Hookworm: "the great infection of mankind". PLoS Med. 2005 Mar; 2(3):e67. PMID: 15783256; PMCID: PMC1069663.
      Citations: 54     Fields:    Translation:HumansPHPublic Health
    239. Kehn K, Fuente Cde L, Strouss K, Berro R, Jiang H, Brady J, Mahieux R, Pumfery A, Bottazzi ME, Kashanchi F. The HTLV-I Tax oncoprotein targets the retinoblastoma protein for proteasomal degradation. Oncogene. 2005 Jan 20; 24(4):525-40. PMID: 15580311.
      Citations: 51     Fields:    Translation:HumansCells
    240. Hotez PJ, Arora S, Bethony J, Bottazzi ME, Loukas A, Correa-Oliveira R, Brooker S. Helminth infections of children: prospects for control. Adv Exp Med Biol. 2005; 568:135-44. PMID: 16108129.
      Citations: 3     Fields:    Translation:HumansAnimals
    241. Kehn K, Berro R, de la Fuente C, Strouss K, Ghedin E, Dadgar S, Bottazzi ME, Pumfery A, Kashanchi F. Mechanisms of HTLV-1 transformation. Front Biosci. 2004 Sep 01; 9:2347-72. PMID: 15353292.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    242. Seelamgari A, Maddukuri A, Berro R, de la Fuente C, Kehn K, Deng L, Dadgar S, Bottazzi ME, Ghedin E, Pumfery A, Kashanchi F. Role of viral regulatory and accessory proteins in HIV-1 replication. Front Biosci. 2004 Sep 01; 9:2388-413. PMID: 15353294.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    243. Hotez PJ, Brooker S, Bethony JM, Bottazzi ME, Loukas A, Xiao S. Hookworm infection. N Engl J Med. 2004 Aug 19; 351(8):799-807. PMID: 15317893.
      Citations: 228     Fields:    Translation:HumansAnimals
    244. Loukas A, Bethony JM, Williamson AL, Goud GN, Mendez S, Zhan B, Hawdon JM, Elena Bottazzi M, Brindley PJ, Hotez PJ. Vaccination of dogs with a recombinant cysteine protease from the intestine of canine hookworms diminishes the fecundity and growth of worms. J Infect Dis. 2004 May 15; 189(10):1952-61. PMID: 15122534.
      Citations: 32     Fields:    Translation:AnimalsPHPublic Health
    245. Kehn K, Deng L, de la Fuente C, Strouss K, Wu K, Maddukuri A, Baylor S, Rufner R, Pumfery A, Bottazzi ME, Kashanchi F. The role of cyclin D2 and p21/waf1 in human T-cell leukemia virus type 1 infected cells. Retrovirology. 2004 Apr 13; 1:6. PMID: 15169570; PMCID: PMC420262.
      Citations: 24     Fields:    Translation:HumansAnimalsCells
    246. Wu K, Bottazzi ME, de la Fuente C, Deng L, Gitlin SD, Maddukuri A, Dadgar S, Li H, Vertes A, Pumfery A, Kashanchi F. Protein profile of tax-associated complexes. J Biol Chem. 2004 Jan 02; 279(1):495-508. PMID: 14530271.
      Citations: 51     Fields:    Translation:HumansCells
    247. Hotez PJ, Zhan B, Bethony JM, Loukas A, Williamson A, Goud GN, Hawdon JM, Dobardzic A, Dobardzic R, Ghosh K, Bottazzi ME, Mendez S, Zook B, Wang Y, Liu S, Essiet-Gibson I, Chung-Debose S, Xiao S, Knox D, Meagher M, Inan M, Correa-Oliveira R, Vilk P, Shepherd HR, Brandt W, Russell PK. Progress in the development of a recombinant vaccine for human hookworm disease: the Human Hookworm Vaccine Initiative. Int J Parasitol. 2003 Sep 30; 33(11):1245-58. PMID: 13678639.
      Citations: 45     Fields:    Translation:HumansAnimals
    248. Bottazzi ME, Buzzai M, Zhu X, Desdouets C, Assoian RK, Br?chot C. Distinct effects of mitogens and the actin cytoskeleton on CREB and pocket protein phosphorylation control the extent and timing of cyclin A promoter activity. Mol Cell Biol. 2001 Nov; 21(22):7607-16. PMID: 11604497; PMCID: PMC99932.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    249. Roovers K, Davey G, Zhu X, Bottazzi ME, Assoian RK. Alpha5beta1 integrin controls cyclin D1 expression by sustaining mitogen-activated protein kinase activity in growth factor-treated cells. Mol Biol Cell. 1999 Oct; 10(10):3197-204. PMID: 10512860; PMCID: PMC25578.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    250. Bottazzi ME, Zhu X, Assoian RK, B?hmer RM. Regulation of p21(cip1) expression by growth factors and the extracellular matrix reveals a role for transient ERK activity in G1 phase. J Cell Biol. 1999 Sep 20; 146(6):1255-64. PMID: 10491389; PMCID: PMC2156121.
      Citations: 35     Fields:    Translation:AnimalsCells
    251. Bottazzi ME, Assoian RK. The extracellular matrix and mitogenic growth factors control G1 phase cyclins and cyclin-dependent kinase inhibitors. Trends Cell Biol. 1997 Sep; 7(9):348-52. PMID: 17708979.
      Citations: 14     Fields:    
    252. . Regulation of Cyclin: A gene transcription by the extracellular matrix. 1997; 118.
    253. Assoian RK, Zhu X, Davey GE, BOTTAZZI ME. . Role of extracellular matrix and cytoskeleton in the regulation of cyclins, cyclin-dependent kinase inhibitors and anchorage-dependent growth. Advances in Molecular and Cell Biology. 1996; (24):57.
    254. Ambrose MR, Bottazzi ME, Goodenow MM. Expression of the c-ski proto-oncogene during cell cycle arrest and myogenic differentiation. DNA Cell Biol. 1995 Aug; 14(8):701-7. PMID: 7646817.
      Citations: 3     Fields:    Translation:AnimalsCells
    255. Bottazzi ME, Goodenow MM, Moscovici MG, Moscovici C. BM2L is a spontaneous leukemogenic variant of a non-leukemogenic v-myb-transformed myeloid cell line. Oncogene. 1993 Mar; 8(3):731-6. PMID: 8437856.
      Citations:    Fields:    Translation:AnimalsCells
    256. . Subcellular localization of v-myb in non-leukemogenic and leukemogenic transformed cells. 1993; 521.
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