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GREG D. CUNY

TitleAssociate Professor
InstitutionUniversity of Houston College of Pharmacy
DepartmentPharmacological & Pharmaceutical Sciences
AddressHealth 2 4849 Calhoun Road, Room 7036
Houston, TX 77204-5037
Houston TX 77204-5037
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    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Gautam A, Boyd DF, Nikhar S, Zhang T, Siokas I, Van de Velde LA, Gaevert J, Meliopoulos V, Thapa B, Rodriguez DA, Cai KQ, Yin C, Schnepf D, Beer J, DeAntoneo C, Williams RM, Shubina M, Livingston B, Zhang D, Andrake MD, Lee S, Boda R, Duddupudi AL, Crawford JC, Vogel P, Loch C, Schwemmle M, Fritz LC, Schultz-Cherry S, Green DR, Cuny GD, Thomas PG, Degterev A, Balachandran S. Necroptosis blockade prevents lung injury in severe influenza. Nature. 2024 Apr 10. PMID: 38600381.
      Citations:    
    2. Chen H, Lye MF, Gorgulla C, Ficarro SB, Cuny GD, Scott DA, Wu F, Rothlauf PW, Wang X, Fernandez R, Pesola JM, Draga S, Marto JA, Hogle JM, Arthanari H, Coen DM. A small molecule exerts selective antiviral activity by targeting the human cytomegalovirus nuclear egress complex. PLoS Pathog. 2023 Nov; 19(11):e1011781. PMID: 37976321; PMCID: PMC10691697.
      Citations: 1     Fields:    Translation:HumansCells
    3. Lawson AP, Hedstrom L, Lee S, Love MS, Modukuri R, Chatterjee AK, Huerta L, McNamara CW, Mead JR, Cuny GD. Structure-activity relationship of BMS906024 derivatives for Cryptosporidium parvum growth inhibition. Bioorg Med Chem Lett. 2023 06 15; 90:129328. PMID: 37196868; PMCID: PMC10290938.
      Citations:    Fields:    Translation:HumansAnimals
    4. Pepi MJ, Chacko S, Kopetz N, Boshoff HIM, Cuny GD, Hedstrom L. Nonhydrolyzable d-phenylalanine-benzoxazole derivatives retain antitubercular activity. Bioorg Med Chem Lett. 2023 01 15; 80:129116. PMID: 36572353; PMCID: PMC9885953.
      Citations:    Fields:    Translation:HumansCells
    5. Haile CN, Baker MD, Sanchez SA, Lopez Arteaga CA, Duddupudi AL, Cuny GD, Norton EB, Kosten TR, Kosten TA. An Immunconjugate Vaccine Alters Distribution and Reduces the Antinociceptive, Behavioral and Physiological Effects of Fentanyl in Male and Female Rats. Pharmaceutics. 2022 Oct 26; 14(11). PMID: 36365109; PMCID: PMC9694531.
      Citations: 4     
    6. Pepi MJ, Chacko S, Marqus GM, Singh V, Wang Z, Planck K, Cullinane RT, Meka PN, Gollapalli DR, Ioerger TR, Rhee KY, Cuny GD, Boshoff HIM, Hedstrom L. A d-Phenylalanine-Benzoxazole Derivative Reveals the Role of the Essential Enzyme Rv3603c in the Pantothenate Biosynthetic Pathway of Mycobacterium tuberculosis. ACS Infect Dis. 2022 02 11; 8(2):330-342. PMID: 35015509; PMCID: PMC9558617.
      Citations:    Fields:    Translation:Cells
    7. Chacko S, Boshoff HIM, Singh V, Ferraris DM, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Rizzi M, Mizrahi V, Cuny GD, Hedstrom L. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents. J Med Chem. 2021 Dec 23; 64(24):18233-18234. PMID: 34855408.
      Citations:    Fields:    
    8. Modi G, Marqus GM, Vippila MR, Gollapalli DR, Kim Y, Manna AC, Chacko S, Maltseva N, Wang X, Cullinane RT, Zhang Y, Kotler JLM, Kuzmic P, Zhang M, Lawson AP, Joachimiak A, Cheung A, Snider BB, Rothstein DM, Cuny GD, Hedstrom L. The Enzymatic Activity of Inosine 5'-Monophosphate Dehydrogenase May Not Be a Vulnerable Target for Staphylococcus aureus Infections. ACS Infect Dis. 2021 11 12; 7(11):3062-3076. PMID: 34590817; PMCID: PMC9575405.
      Citations:    Fields:    Translation:AnimalsCells
    9. Xie L, Li R, Zheng B, Xie Z, Fang X, Wang Y, Cuny GD, Li Z, Lin B, Chen X, Hu M. Development of Rofecoxib-Based Fluorescent Probes and Investigations on Their Solvatochromism, AIE Activity, Mechanochromism, and COX-2-Targeted Bioimaging. Anal Chem. 2021 09 07; 93(35):11991-12000. PMID: 34424685.
      Citations:    Fields:    Translation:Humans
    10. Vemulapalli V, Donovan KA, Seegar TCM, Rogers JM, Bae M, Lumpkin RJ, Cao R, Henke MT, Ray SS, Fischer ES, Cuny GD, Blacklow SC. Targeted Degradation of the Oncogenic Phosphatase SHP2. Biochemistry. 2021 08 31; 60(34):2593-2609. PMID: 34411482; PMCID: PMC8410664.
      Citations: 4     Fields:    Translation:HumansCells
    11. Ali G, Cuny GD. 8-, 9-, and 11-Aryloxy Dimeric Aporphines and Their Pharmacological Activities. Molecules. 2021 Jul 27; 26(15). PMID: 34361671; PMCID: PMC8347945.
      Citations:    Fields:    Translation:AnimalsCells
    12. Ali G, Cuny GD. Syntheses of Gymnothespirolignans B and C and Non-natural Isomer 9-Epi-gymnothespirolignan B. J Org Chem. 2021 08 06; 86(15):10517-10525. PMID: 34282914.
      Citations:    Fields:    Translation:Cells
    13. Delanghe T, Huyghe J, Lee S, Priem D, Van Coillie S, Gilbert B, Choi SM, Vandenabeele P, Degterev A, Cuny GD, Dondelinger Y, Bertrand MJM. Antioxidant and food additive BHA prevents TNF cytotoxicity by acting as a direct RIPK1 inhibitor. Cell Death Dis. 2021 07 14; 12(7):699. PMID: 34262020; PMCID: PMC8280128.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    14. Stone AE, Scheuermann SE, Haile CN, Cuny GD, Velasquez ML, Linhuber JP, Duddupudi AL, Vigliaturo JR, Pravetoni M, Kosten TA, Kosten TR, Norton EB. Fentanyl conjugate vaccine by injected or mucosal delivery with dmLT or LTA1 adjuvants implicates IgA in protection from drug challenge. NPJ Vaccines. 2021 May 13; 6(1):69. PMID: 33986280; PMCID: PMC8119695.
      Citations: 1     
    15. Xie L, Li R, Zheng B, Xie Z, Fang X, Dai T, Wang X, Li L, Wang L, Cuny GD, Eriksen J, Tu D, Chen Z, Wang X, Chen X, Hu M. One-Step Transformation from Rofecoxib to a COX-2 NIR Probe for Human Cancer Tissue/Organoid Targeted Bioimaging. ACS Appl Bio Mater. 2021 03 15; 4(3):2723-2731. PMID: 35014311.
      Citations:    Fields:    Translation:HumansAnimalsCells
    16. Nikhar S, Siokas I, Schlicher L, Lee S, Gyrd-Hansen M, Degterev A, Cuny GD. Design of pyrido[2,3-d]pyrimidin-7-one inhibitors of receptor interacting protein kinase-2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling. Eur J Med Chem. 2021 Apr 05; 215:113252. PMID: 33601309; PMCID: PMC8009825.
      Citations:    Fields:    Translation:HumansCells
    17. Lee S, Ku AF, Vippila MR, Wang Y, Zhang M, Wang X, Hedstrom L, Cuny GD. Mycophenolic anilides as broad specificity inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors. Bioorg Med Chem Lett. 2020 12 15; 30(24):127543. PMID: 32931912; PMCID: PMC9511823.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    18. Cuny GD, Degterev A. RIPK protein kinase family: Atypical lives of typical kinases. Semin Cell Dev Biol. 2021 01; 109:96-105. PMID: 32732131; PMCID: PMC8286629.
      Citations: 7     Fields:    Translation:Humans
    19. Suebsuwong C, Dai B, Pinkas DM, Duddupudi AL, Li L, Bufton JC, Schlicher L, Gyrd-Hansen M, Hu M, Bullock AN, Degterev A, Cuny GD. Receptor-interacting protein kinase 2 (RIPK2) and nucleotide-binding oligomerization domain (NOD) cell signaling inhibitors based on a 3,5-diphenyl-2-aminopyridine scaffold. Eur J Med Chem. 2020 Aug 15; 200:112417. PMID: 32505849; PMCID: PMC7338260.
      Citations: 3     Fields:    Translation:HumansCells
    20. Duddupudi AL, Pandey P, Vo H, Welsh CL, Doerksen RJ, Cuny GD. Hypervalent Iodine Mediated Oxidative Cyclization of Acrylamide N-Carbamates to 5,5-Disubstituted Oxazolidine-2,4-diones. J Org Chem. 2020 06 05; 85(11):7549-7557. PMID: 32392063.
      Citations:    Fields:    
    21. Ali G, Cuny GD. Synthesis of the Tetracyclic Framework of Polycyclic Spiro Lignan Natural Products. ACS Omega. 2020 Apr 21; 5(15):9007-9012. PMID: 32337465; PMCID: PMC7178799.
      Citations:    
    22. Pawlowic MC, Somepalli M, Sateriale A, Herbert GT, Gibson AR, Cuny GD, Hedstrom L, Striepen B. Genetic ablation of purine salvage in Cryptosporidium parvum reveals nucleotide uptake from the host cell. Proc Natl Acad Sci U S A. 2019 10 15; 116(42):21160-21165. PMID: 31570573; PMCID: PMC6800313.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    23. Kearney SE, Brimacombe KR, Henderson MJ, Lynch C, Zhao T, Wan KK, Itkin Z, Dillon C, Shen M, Cheff DM, Lee TD, Bougie D, Cheng K, Coussens NP, Dorjsuren D, Eastman RT, Huang R, Iannotti MJ, Karavadhi S, Klumpp-Thomas C, Roth JS, Sakamuru S, Sun W, Titus SA, Yasgar A, Zhang YQ, Zhao J, Andrade RB, Brown MK, Burns NZ, Cha JK, Mevers EE, Clardy J, Clement JA, Crooks PA, Cuny GD, Ganor J, Moreno J, Morrill LA, Picazo E, Susick RB, Garg NK, Goess BC, Grossman RB, Hughes CC, Johnston JN, Joullie MM, Kinghorn AD, Kingston DGI, Krische MJ, Kwon O, Maimone TJ, Majumdar S, Maloney KN, Mohamed E, Murphy BT, Nagorny P, Olson DE, Overman LE, Brown LE, Snyder JK, Porco JA, Rivas F, Ross SA, Sarpong R, Sharma I, Shaw JT, Xu Z, Shen B, Shi W, Stephenson CRJ, Verano AL, Tan DS, Tang Y, Taylor RE, Thomson RJ, Vosburg DA, Wu J, Wuest WM, Zakarian A, Zhang Y, Ren T, Zuo Z, Inglese J, Michael S, Simeonov A, Zheng W, Shinn P, Jadhav A, Boxer MB, Hall MD, Xia M, Guha R, Rohde JM, Zahor?nszky-Kohalmi G. Canvass: A Crowd-Sourced, Natural-Product Screening Library for Exploring Biological Space. ACS Cent Sci. 2018 Dec 26; 4(12):1727-1741. PMID: 30648156; PMCID: PMC6311695.
      Citations: 17     
    24. Jiang JK, Huang X, Shamim K, Patel PR, Lee A, Wang AQ, Nguyen K, Tawa G, Cuny GD, Yu PB, Zheng W, Xu X, Sanderson P, Huang W. Discovery of 3-(4-sulfamoylnaphthyl)pyrazolo[1,5-a]pyrimidines as potent and selective ALK2 inhibitors. Bioorg Med Chem Lett. 2018 11 01; 28(20):3356-3362. PMID: 30227946; PMCID: PMC6218249.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    25. Hrdinka M, Schlicher L, Dai B, Pinkas DM, Bufton JC, Picaud S, Ward JA, Rogers C, Suebsuwong C, Nikhar S, Cuny GD, Huber KV, Filippakopoulos P, Bullock AN, Degterev A, Gyrd-Hansen M. Small molecule inhibitors reveal an indispensable scaffolding role of RIPK2 in NOD2 signaling. EMBO J. 2018 09 03; 37(17). PMID: 30026309; PMCID: PMC6120666.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    26. Chacko S, Boshoff HIM, Singh V, Gollapalli DR, Zhang M, Lawson AP, Pepi MJ, Joachimiak A, Mizrahi V, Cuny GD, Hedstrom L, Ferraris DM, Rizzi M. Expanding Benzoxazole-Based Inosine 5'-Monophosphate Dehydrogenase (IMPDH) Inhibitor Structure-Activity As Potential Antituberculosis Agents. J Med Chem. 2018 06 14; 61(11):4739-4756. PMID: 29746130; PMCID: PMC6166404.
      Citations: 10     Fields:    Translation:HumansCells
    27. Suebsuwong C, Pinkas DM, Ray SS, Bufton JC, Dai B, Bullock AN, Degterev A, Cuny GD. Activation loop targeting strategy for design of receptor-interacting protein kinase 2 (RIPK2) inhibitors. Bioorg Med Chem Lett. 2018 02 15; 28(4):577-583. PMID: 29409752; PMCID: PMC5819902.
      Citations: 5     Fields:    Translation:HumansCells
    28. Ku AF, Cuny GD. Discovery of 7-hydroxyaporphines as conformationally restricted ligands for beta-1 and beta-2 adrenergic receptors. Medchemcomm. 2018 Feb 01; 9(2):353-356. PMID: 30108929; PMCID: PMC6083790.
      Citations: 1     
    29. Choi S, Calder AN, Miller EH, Anderson KP, Fiejtek DK, Rietz A, Li H, Cherry JJ, Quist KM, Xing X, Glicksman MA, Cuny GD, Lorson CL, Androphy EA, Hodgetts KJ. Optimization of a series of heterocycles as survival motor neuron gene transcription enhancers. Bioorg Med Chem Lett. 2017 12 01; 27(23):5144-5148. PMID: 29103974; PMCID: PMC5701662.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Gorla SK, Zhang Y, Rabideau MM, Qin A, Chacko S, House AL, Johnson CR, Mandapati K, Bernstein HM, McKenney ES, Boshoff H, Zhang M, Glomski IJ, Goldberg JB, Cuny GD, Mann BJ, Hedstrom L. Benzoxazoles, Phthalazinones, and Arylurea-Based Compounds with IMP Dehydrogenase-Independent Antibacterial Activity against Francisella tularensis. Antimicrob Agents Chemother. 2017 10; 61(10). PMID: 28739786; PMCID: PMC5610529.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    31. Rietz A, Li H, Quist KM, Cherry JJ, Lorson CL, Burnett BG, Kern NL, Calder AN, Fritsche M, Lusic H, Boaler PJ, Choi S, Xing X, Glicksman MA, Cuny GD, Androphy EJ, Hodgetts KJ. Discovery of a Small Molecule Probe That Post-Translationally Stabilizes the Survival Motor Neuron Protein for the Treatment of Spinal Muscular Atrophy. J Med Chem. 2017 06 08; 60(11):4594-4610. PMID: 28481536; PMCID: PMC5920559.
      Citations: 3     Fields:    Translation:HumansCells
    32. Cuny GD, Suebsuwong C, Ray SS. Inosine-5'-monophosphate dehydrogenase (IMPDH) inhibitors: a patent and scientific literature review (2002-2016). Expert Opin Ther Pat. 2017 Jun; 27(6):677-690. PMID: 28074661.
      Citations: 12     Fields:    Translation:HumansAnimals
    33. Ku AF, Cuny GD. Access to 6a-Alkyl Aporphines: Synthesis of (?)-N-Methylguattescidine. J Org Chem. 2016 10 21; 81(20):10062-10070. PMID: 27689544.
      Citations: 2     Fields:    
    34. Vippila MR, Nikhar S, Gracia AP, Cuny GD. Divergent Approach for the Synthesis of Gombamide A and Derivatives. Org Lett. 2016 09 16; 18(18):4726-9. PMID: 27603447.
      Citations: 1     Fields:    Translation:HumansCells
    35. Vippila MR, Ly PK, Cuny GD. Synthesis and Antiproliferative Activity Evaluation of the Disulfide-Containing Cyclic Peptide Thiochondrilline C and Derivatives. J Nat Prod. 2015 Oct 23; 78(10):2398-404. PMID: 26444379.
      Citations: 3     Fields:    Translation:HumansCells
    36. Makowska-Grzyska M, Kim Y, Gorla SK, Wei Y, Mandapati K, Zhang M, Maltseva N, Modi G, Boshoff HI, Gu M, Aldrich C, Cuny GD, Hedstrom L, Joachimiak A. Mycobacterium tuberculosis IMPDH in Complexes with Substrates, Products and Antitubercular Compounds. PLoS One. 2015; 10(10):e0138976. PMID: 26440283; PMCID: PMC4594927.
      Citations: 14     Fields:    Translation:Cells
    37. Canning P, Schwerd T, Hrdinka M, Saleh D, Suebsuwong C, Brennan PE, Cuny GD, Uhlig HH, Gyrd-Hansen M, Bullock AN, Ruan Q, Maki JL, Ray S, Degterev A. Inflammatory Signaling by NOD-RIPK2 Is Inhibited by Clinically Relevant Type II Kinase Inhibitors. Chem Biol. 2015 Sep 17; 22(9):1174-84. PMID: 26320862; PMCID: PMC4579271.
      Citations: 40     Fields:    Translation:HumansAnimalsCells
    38. Kim Y, Makowska-Grzyska M, Gorla SK, Gollapalli DR, Cuny GD, Joachimiak A, Hedstrom L. Structure of Cryptosporidium IMP dehydrogenase bound to an inhibitor with in vivo antiparasitic activity. Acta Crystallogr F Struct Biol Commun. 2015 May; 71(Pt 5):531-8. PMID: 25945705; PMCID: PMC4427161.
      Citations: 1     Fields:    Translation:AnimalsCells
    39. Lang CA, Ray SS, Liu M, Singh AK, Cuny GD. Discovery of LRRK2 inhibitors using sequential in silico joint pharmacophore space (JPS) and ensemble docking. Bioorg Med Chem Lett. 2015 Jul 01; 25(13):2713-9. PMID: 25998502.
      Citations: 5     Fields:    Translation:HumansCells
    40. Najjar M, Suebsuwong C, Ray SS, Thapa RJ, Maki JL, Nogusa S, Shah S, Saleh D, Gough PJ, Bertin J, Yuan J, Balachandran S, Cuny GD, Degterev A. Structure guided design of potent and selective ponatinib-based hybrid inhibitors for RIPK1. Cell Rep. 2015 Mar 24; 10(11):1850-60. PMID: 25801024; PMCID: PMC4494889.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    41. Cuny GD, Ku AF. Synthetic studies of 7-oxygenated aporphine alkaloids: preparation of (-)-oliveroline, (-)-nornuciferidine, and derivatives. Org Lett. 2015 Mar 06; 17(5):1134-7. PMID: 25710592.
      Citations: 2     Fields:    Translation:Cells
    42. Takahashi K, Kong Q, Lin Y, Stouffer N, Schulte DA, Lai L, Liu Q, Chang LC, Dominguez S, Xing X, Cuny GD, Hodgetts KJ, Glicksman MA, Lin CL. Restored glial glutamate transporter EAAT2 function as a potential therapeutic approach for Alzheimer's disease. J Exp Med. 2015 Mar 09; 212(3):319-32. PMID: 25711212; PMCID: PMC4354363.
      Citations: 44     Fields:    Translation:AnimalsCells
    43. Sun Z, Khan J, Makowska-Grzyska M, Zhang M, Cho JH, Suebsuwong C, Vo P, Gollapalli DR, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Synthesis, in vitro evaluation and cocrystal structure of 4-oxo-[1]benzopyrano[4,3-c]pyrazole Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase (CpIMPDH) inhibitors. J Med Chem. 2014 Dec 26; 57(24):10544-50. PMID: 25474504; PMCID: PMC4281095.
      Citations: 11     Fields:    Translation:AnimalsCells
    44. Mohedas AH, Wang Y, Sanvitale CE, Canning P, Choi S, Xing X, Bullock AN, Cuny GD, Yu PB. Structure-activity relationship of 3,5-diaryl-2-aminopyridine ALK2 inhibitors reveals unaltered binding affinity for fibrodysplasia ossificans progressiva causing mutants. J Med Chem. 2014 Oct 09; 57(19):7900-15. PMID: 25101911; PMCID: PMC4191596.
      Citations: 43     Fields:    Translation:Humans
    45. Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. Inhibitor of the tyrosine phosphatase STEP reverses cognitive deficits in a mouse model of Alzheimer's disease. PLoS Biol. 2014 Aug; 12(8):e1001923. PMID: 25093460; PMCID: PMC4122355.
      Citations: 57     Fields:    Translation:HumansAnimalsCells
    46. Mandapati K, Gorla SK, House AL, McKenney ES, Zhang M, Rao SN, Gollapalli DR, Mann BJ, Goldberg JB, Cuny GD, Glomski IJ, Hedstrom L. Repurposing cryptosporidium inosine 5'-monophosphate dehydrogenase inhibitors as potential antibacterial agents. ACS Med Chem Lett. 2014 Aug 14; 5(8):846-50. PMID: 25147601; PMCID: PMC4137380.
      Citations: 12     
    47. Pytel D, Seyb K, Liu M, Ray SS, Concannon J, Huang M, Cuny GD, Diehl JA, Glicksman MA. Enzymatic Characterization of ER Stress-Dependent Kinase, PERK, and Development of a High-Throughput Assay for Identification of PERK Inhibitors. J Biomol Screen. 2014 Aug; 19(7):1024-34. PMID: 24598103; PMCID: PMC4570879.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    48. Kong Q, Chang LC, Takahashi K, Liu Q, Schulte DA, Lai L, Ibabao B, Lin Y, Stouffer N, Das Mukhopadhyay C, Xing X, Seyb KI, Cuny GD, Glicksman MA, Lin CL. Small-molecule activator of glutamate transporter EAAT2 translation provides neuroprotection. J Clin Invest. 2014 Mar; 124(3):1255-67. PMID: 24569372; PMCID: PMC3938250.
      Citations: 48     Fields:    Translation:AnimalsCells
    49. Gorla SK, McNair NN, Yang G, Gao S, Hu M, Jala VR, Haribabu B, Striepen B, Cuny GD, Mead JR, Hedstrom L. Validation of IMP dehydrogenase inhibitors in a mouse model of cryptosporidiosis. Antimicrob Agents Chemother. 2014; 58(3):1603-14. PMID: 24366728; PMCID: PMC3957894.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    50. Mistry H, Hsieh G, Buhrlage SJ, Huang M, Park E, Cuny GD, Galinsky I, Stone RM, Gray NS, D'Andrea AD, Parmar K. Small-molecule inhibitors of USP1 target ID1 degradation in leukemic cells. Mol Cancer Ther. 2013 Dec; 12(12):2651-62. PMID: 24130053; PMCID: PMC4089878.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    51. Wang X, Cuny GD, No?l T. A mild, one-pot Stadler-Ziegler synthesis of arylsulfides facilitated by photoredox catalysis in batch and continuous-flow. Angew Chem Int Ed Engl. 2013 Jul 22; 52(30):7860-4. PMID: 23784666.
      Citations: 12     Fields:    Translation:Cells
    52. Cherry JJ, Osman EY, Evans MC, Choi S, Xing X, Cuny GD, Glicksman MA, Lorson CL, Androphy EJ. Enhancement of SMN protein levels in a mouse model of spinal muscular atrophy using novel drug-like compounds. EMBO Mol Med. 2013 Jul; 5(7):1103-18. PMID: 23740718; PMCID: PMC3721476.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    53. Zhang X, Hernandez I, Rei D, Mair W, Laha JK, Cornwell ME, Cuny GD, Tsai LH, Steen JA, Kosik KS. Diaminothiazoles modify Tau phosphorylation and improve the tauopathy in mouse models. J Biol Chem. 2013 Jul 26; 288(30):22042-56. PMID: 23737518; PMCID: PMC3724657.
      Citations: 20     Fields:    Translation:HumansAnimalsCells
    54. Gorla SK, Kavitha M, Zhang M, Chin JE, Liu X, Striepen B, Makowska-Grzyska M, Kim Y, Joachimiak A, Hedstrom L, Cuny GD. Optimization of benzoxazole-based inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2013 May 23; 56(10):4028-43. PMID: 23668331; PMCID: PMC3756936.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    55. Sanvitale CE, Kerr G, Chaikuad A, Ramel MC, Mohedas AH, Reichert S, Wang Y, Triffitt JT, Cuny GD, Yu PB, Hill CS, Bullock AN. A new class of small molecule inhibitor of BMP signaling. PLoS One. 2013; 8(4):e62721. PMID: 23646137; PMCID: PMC3639963.
      Citations: 112     Fields:    Translation:HumansAnimalsCells
    56. Mohedas AH, Xing X, Armstrong KA, Bullock AN, Cuny GD, Yu PB. Development of an ALK2-biased BMP type I receptor kinase inhibitor. ACS Chem Biol. 2013; 8(6):1291-302. PMID: 23547776; PMCID: PMC3901569.
      Citations: 70     Fields:    Translation:HumansAnimalsCells
    57. Maki JL, Tres Brazell J, Teng X, Cuny GD, Degterev A. Expression and purification of active receptor interacting protein 1 kinase using a baculovirus system. Protein Expr Purif. 2013 Jun; 89(2):156-61. PMID: 23523699; PMCID: PMC3653991.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    58. Liu M, Bender SA, Cuny GD, Sherman W, Glicksman M, Ray SS. Type II kinase inhibitors show an unexpected inhibition mode against Parkinson's disease-linked LRRK2 mutant G2019S. Biochemistry. 2013 Mar 12; 52(10):1725-36. PMID: 23379419; PMCID: PMC3966205.
      Citations: 12     Fields:    Translation:HumansCells
    59. Johnson CR, Gorla SK, Kavitha M, Zhang M, Liu X, Striepen B, Mead JR, Cuny GD, Hedstrom L. Phthalazinone inhibitors of inosine-5'-monophosphate dehydrogenase from Cryptosporidium parvum. Bioorg Med Chem Lett. 2013 Feb 15; 23(4):1004-7. PMID: 23324406; PMCID: PMC3557747.
      Citations: 15     Fields:    Translation:HumansAnimals
    60. Gorla SK, Kavitha M, Zhang M, Liu X, Sharling L, Gollapalli DR, Striepen B, Hedstrom L, Cuny GD. Selective and potent urea inhibitors of cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2012 Sep 13; 55(17):7759-71. PMID: 22950983; PMCID: PMC3635066.
      Citations: 21     Fields:    Translation:HumansAnimals
    61. Cuny GD. Foreword: neurodegenerative diseases: challenges and opportunities. Future Med Chem. 2012 Sep; 4(13):1647-9. PMID: 22924500.
      Citations: 7     Fields:    Translation:Humans
    62. Abraham CR, Chen C, Cuny GD, Glicksman MA, Zeldich E. Small-molecule Klotho enhancers as novel treatment of neurodegeneration. Future Med Chem. 2012 Sep; 4(13):1671-9. PMID: 22924505; PMCID: PMC3564652.
      Citations: 30     Fields:    Translation:HumansAnimalsCells
    63. Lin CL, Kong Q, Cuny GD, Glicksman MA. Glutamate transporter EAAT2: a new target for the treatment of neurodegenerative diseases. Future Med Chem. 2012 Sep; 4(13):1689-700. PMID: 22924507; PMCID: PMC3580837.
      Citations: 50     Fields:    Translation:HumansAnimals
    64. Choi S, Keys H, Staples RJ, Yuan J, Degterev A, Cuny GD. Optimization of tricyclic Nec-3 necroptosis inhibitors for in vitro liver microsomal stability. Bioorg Med Chem Lett. 2012 Sep 01; 22(17):5685-8. PMID: 22832318; PMCID: PMC3434878.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    65. Wright PD, Wightman N, Huang M, Weiss A, Sapp PC, Cuny GD, Ivinson AJ, Glicksman MA, Ferrante RJ, Matson W, Matson S, Brown RH. A high-throughput screen to identify inhibitors of SOD1 transcription. Front Biosci (Elite Ed). 2012 06 01; 4(8):2701-8. PMID: 22652679; PMCID: PMC4083181.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    66. Maki JL, Smith EE, Teng X, Ray SS, Cuny GD, Degterev A. Fluorescence polarization assay for inhibitors of the kinase domain of receptor interacting protein 1. Anal Biochem. 2012 Aug 15; 427(2):164-74. PMID: 22658960; PMCID: PMC3398245.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    67. Hellal M, Singh S, Cuny GD. Synthesis of tetracyclic indoles via intramolecular a-arylation of ketones. J Org Chem. 2012 Apr 20; 77(8):4123-30. PMID: 22480284.
      Citations: 1     Fields:    Translation:Cells
    68. Ezgimen M, Lai H, Mueller NH, Lee K, Cuny G, Ostrov DA, Padmanabhan R. Characterization of the 8-hydroxyquinoline scaffold for inhibitors of West Nile virus serine protease. Antiviral Res. 2012 Apr; 94(1):18-24. PMID: 22343093; PMCID: PMC3331929.
      Citations: 14     Fields:    Translation:HumansCells
    69. Cuny GD, Ulyanova NP, Patnaik D, Liu JF, Lin X, Auerbach K, Ray SS, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of beta-carboline derivatives as haspin kinase inhibitors. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):2015-9. PMID: 22335895; PMCID: PMC3288743.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    70. Kirubakaran S, Gorla SK, Sharling L, Zhang M, Liu X, Ray SS, Macpherson IS, Striepen B, Hedstrom L, Cuny GD. Structure-activity relationship study of selective benzimidazole-based inhibitors of Cryptosporidium parvum IMPDH. Bioorg Med Chem Lett. 2012 Mar 01; 22(5):1985-8. PMID: 22310229; PMCID: PMC3289519.
      Citations: 25     Fields:    Translation:HumansAnimals
    71. Cherry JJ, Evans MC, Ni J, Cuny GD, Glicksman MA, Androphy EJ. Identification of novel compounds that increase SMN protein levels using an improved SMN2 reporter cell assay. J Biomol Screen. 2012 Apr; 17(4):481-95. PMID: 22233647; PMCID: PMC3870337.
      Citations: 14     Fields:    Translation:HumansCells
    72. So PP, Zeldich E, Seyb KI, Huang MM, Concannon JB, King GD, Chen CD, Cuny GD, Glicksman MA, Abraham CR. Lowering of amyloid beta peptide production with a small molecule inhibitor of amyloid-? precursor protein dimerization. Am J Neurodegener Dis. 2012; 1(1):75-87. PMID: 22822474; PMCID: PMC3560454.
      Citations: 14     
    73. King GD, Chen C, Huang MM, Zeldich E, Brazee PL, Schuman ER, Robin M, Cuny GD, Glicksman MA, Abraham CR. Identification of novel small molecules that elevate Klotho expression. Biochem J. 2012 Jan 01; 441(1):453-61. PMID: 21939436; PMCID: PMC3677209.
      Citations: 31     Fields:    Translation:AnimalsCells
    74. Hart MJ, Glicksman M, Liu M, Sharma MK, Cuny G, Galvan V. Development of a high-throughput screen targeting caspase-8-mediated cleavage of the amyloid precursor protein. Anal Biochem. 2012 Feb 15; 421(2):467-76. PMID: 22178911.
      Citations: 4     Fields:    Translation:HumansCells
    75. Liu M, Kang S, Ray S, Jackson J, Zaitsev AD, Gerber SA, Cuny GD, Glicksman MA. Kinetic, mechanistic, and structural modeling studies of truncated wild-type leucine-rich repeat kinase 2 and the G2019S mutant. Biochemistry. 2011 Nov 01; 50(43):9399-408. PMID: 21961647; PMCID: PMC3205922.
      Citations: 16     Fields:    Translation:HumansCells
    76. Pejo E, Cotten JF, Kelly EW, Le Ge R, Cuny GD, Laha JK, Liu J, Lin XJ, Raines DE. In vivo and in vitro pharmacological studies of methoxycarbonyl-carboetomidate. Anesth Analg. 2012 Aug; 115(2):297-304. PMID: 21965364; PMCID: PMC3252484.
      Citations: 19     Fields:    Translation:AnimalsCells
    77. Laha JK, Cuny GD. Synthesis of fused imidazoles, pyrroles, and indoles with a defined stereocenter a to nitrogen utilizing Mitsunobu alkylation followed by palladium-catalyzed cyclization. J Org Chem. 2011 Oct 21; 76(20):8477-82. PMID: 21913645.
      Citations: 2     Fields:    Translation:HumansCells
    78. Xing X, Chang LC, Kong Q, Colton CK, Lai L, Glicksman MA, Lin CL, Cuny GD. Structure-activity relationship study of pyridazine derivatives as glutamate transporter EAAT2 activators. Bioorg Med Chem Lett. 2011 Oct 01; 21(19):5774-7. PMID: 21875806; PMCID: PMC3172717.
      Citations: 20     Fields:    Translation:Cells
    79. Laha JK, Barolo SM, Rossi RA, Cuny GD. Synthesis of carbolines by photostimulated cyclization of anilinohalopyridines. J Org Chem. 2011 Aug 05; 76(15):6421-5. PMID: 21739958.
      Citations: 2     Fields:    Translation:Cells
    80. Shishova EY, Stoll JM, Ersoy BA, Shrestha S, Scapa EF, Li Y, Niepel MW, Su Y, Jelicks LA, Stahl GL, Glicksman MA, Gutierrez-Juarez R, Cuny GD, Cohen DE. Genetic ablation or chemical inhibition of phosphatidylcholine transfer protein attenuates diet-induced hepatic glucose production. Hepatology. 2011 Aug; 54(2):664-74. PMID: 21538437; PMCID: PMC3144994.
      Citations: 12     Fields:    Translation:Animals
    81. Steinbicker AU, Sachidanandan C, Vonner AJ, Yusuf RZ, Deng DY, Lai CS, Rauwerdink KM, Winn JC, Saez B, Cook CM, Szekely BA, Roy CN, Seehra JS, Cuny GD, Scadden DT, Peterson RT, Bloch KD, Yu PB. Inhibition of bone morphogenetic protein signaling attenuates anemia associated with inflammation. Blood. 2011 May 05; 117(18):4915-23. PMID: 21393479; PMCID: PMC3100698.
      Citations: 95     Fields:    Translation:HumansAnimalsCells
    82. Laha JK, Zhang X, Qiao L, Liu M, Chatterjee S, Robinson S, Kosik KS, Cuny GD. Structure-activity relationship study of 2,4-diaminothiazoles as Cdk5/p25 kinase inhibitors. Bioorg Med Chem Lett. 2011 Apr 01; 21(7):2098-101. PMID: 21353545; PMCID: PMC3062192.
      Citations: 7     Fields:    Translation:Animals
    83. Zeng X, Sigoillot F, Gaur S, Choi S, Pfaff KL, Oh DC, Hathaway N, Dimova N, Cuny GD, King RW. Pharmacologic inhibition of the anaphase-promoting complex induces a spindle checkpoint-dependent mitotic arrest in the absence of spindle damage. Cancer Cell. 2010 Oct 19; 18(4):382-95. PMID: 20951947; PMCID: PMC2957475.
      Citations: 169     Fields:    Translation:HumansAnimalsCells
    84. Hellal M, Cuny GD. Synthesis of the indolizino[7,6-c]quinoline alkaloid isaindigotidione. Org Lett. 2010 Oct 15; 12(20):4628-31. PMID: 20845915.
      Citations:    Fields:    Translation:Cells
    85. Cuny GD, Robin M, Ulyanova NP, Patnaik D, Pique V, Casano G, Liu JF, Lin X, Xian J, Glicksman MA, Stein RL, Higgins JM. Structure-activity relationship study of acridine analogs as haspin and DYRK2 kinase inhibitors. Bioorg Med Chem Lett. 2010 Jun 15; 20(12):3491-4. PMID: 20836251; PMCID: PMC3118465.
      Citations: 20     Fields:    Translation:Humans
    86. Liu M, Poulose S, Schuman E, Zaitsev AD, Dobson B, Auerbach K, Seyb K, Cuny GD, Glicksman MA, Stein RL, Yue Z. Development of a mechanism-based high-throughput screen assay for leucine-rich repeat kinase 2--discovery of LRRK2 inhibitors. Anal Biochem. 2010 Sep 15; 404(2):186-92. PMID: 20566370; PMCID: PMC2921631.
      Citations: 11     Fields:    Translation:HumansCells
    87. Colton CK, Kong Q, Lai L, Zhu MX, Seyb KI, Cuny GD, Xian J, Glicksman MA, Lin CL. Identification of translational activators of glial glutamate transporter EAAT2 through cell-based high-throughput screening: an approach to prevent excitotoxicity. J Biomol Screen. 2010 Jul; 15(6):653-62. PMID: 20508255; PMCID: PMC3016154.
      Citations: 35     Fields:    Translation:HumansCells
    88. Hellal M, Cuny GD. Intramolecular Aldol reaction of N-acylated (2-aminophenyl)-alpha-oxoacetic acids: rapid access to tri- and tetracyclic 1,2-dihydroquinolin-2(1H)-ones. J Org Chem. 2010 May 21; 75(10):3465-8. PMID: 20394404.
      Citations: 2     Fields:    Translation:Cells
    89. Rosenbaum DM, Degterev A, David J, Rosenbaum PS, Roth S, Grotta JC, Cuny GD, Yuan J, Savitz SI. Necroptosis, a novel form of caspase-independent cell death, contributes to neuronal damage in a retinal ischemia-reperfusion injury model. J Neurosci Res. 2010 May 15; 88(7):1569-76. PMID: 20025059; PMCID: PMC7713513.
      Citations: 110     Fields:    Translation:AnimalsCells
    90. Leissring MA, Malito E, Hedouin S, Reinstatler L, Sahara T, Abdul-Hay SO, Choudhry S, Maharvi GM, Fauq AH, Huzarska M, May PS, Choi S, Logan TP, Turk BE, Cantley LC, Manolopoulou M, Tang WJ, Stein RL, Cuny GD, Selkoe DJ. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One. 2010 May 07; 5(5):e10504. PMID: 20498699; PMCID: PMC2866327.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    91. Nowak RJ, Cuny GD, Choi S, Lansbury PT, Ray SS. Improving binding specificity of pharmacological chaperones that target mutant superoxide dismutase-1 linked to familial amyotrophic lateral sclerosis using computational methods. J Med Chem. 2010 Apr 08; 53(7):2709-18. PMID: 20232802; PMCID: PMC2881568.
      Citations: 16     Fields:    Translation:HumansCells
    92. Liu M, El-Turk F, Cuny GD, Glicksman MA, Lashuel HA, Ouertatani-Sakouhi H. Kinetic-based high-throughput screening assay to discover novel classes of macrophage migration inhibitory factor inhibitors. J Biomol Screen. 2010 Apr; 15(4):347-58. PMID: 20231420.
      Citations: 6     Fields:    Translation:AnimalsCells
    93. Cotten JF, Forman SA, Laha JK, Cuny GD, Husain SS, Miller KW, Nguyen HH, Kelly EW, Stewart D, Liu A, Raines DE. Carboetomidate: a pyrrole analog of etomidate designed not to suppress adrenocortical function. Anesthesiology. 2010 Mar; 112(3):637-44. PMID: 20179500; PMCID: PMC2830733.
      Citations: 33     Fields:    Translation:Animals
    94. Macpherson IS, Kirubakaran S, Gorla SK, Riera TV, D'Aquino JA, Zhang M, Cuny GD, Hedstrom L. The structural basis of Cryptosporidium -specific IMP dehydrogenase inhibitor selectivity. J Am Chem Soc. 2010 Feb 03; 132(4):1230-1. PMID: 20052976; PMCID: PMC2819028.
      Citations: 34     Fields:    Translation:HumansAnimals
    95. Lee K, Campbell J, Swoboda JG, Cuny GD, Walker S. Development of improved inhibitors of wall teichoic acid biosynthesis with potent activity against Staphylococcus aureus. Bioorg Med Chem Lett. 2010 Mar 01; 20(5):1767-70. PMID: 20138521; PMCID: PMC2844852.
      Citations: 28     Fields:    Translation:Cells
    96. Qiao L, Choi S, Case A, Gainer TG, Seyb K, Glicksman MA, Lo DC, Stein RL, Cuny GD. Structure-activity relationship study of EphB3 receptor tyrosine kinase inhibitors. Bioorg Med Chem Lett. 2009 Nov 01; 19(21):6122-6. PMID: 19783434; PMCID: PMC2785710.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    97. Maurya SK, Gollapalli DR, Kirubakaran S, Zhang M, Johnson CR, Benjamin NN, Hedstrom L, Cuny GD. Triazole inhibitors of Cryptosporidium parvum inosine 5'-monophosphate dehydrogenase. J Med Chem. 2009 Aug 13; 52(15):4623-30. PMID: 19624136; PMCID: PMC2810100.
      Citations: 32     Fields:    Translation:Animals
    98. Cuny GD. A new class of UDP-3-O-(R-3-hydroxymyristol)-N-acetylglucosamine deacetylase (LpxC) inhibitors for the treatment of Gram-negative infections: PCT application WO 2008027466. Expert Opin Ther Pat. 2009 Jun; 19(6):893-9. PMID: 19473108.
      Citations: 2     Fields:    Translation:HumansCells
    99. Call MJ, Xing X, Cuny GD, Seth NP, Altmann DM, Fugger L, Krogsgaard M, Stein RL, Wucherpfennig KW. In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange. J Immunol. 2009 May 15; 182(10):6342-52. PMID: 19414787; PMCID: PMC2695398.
      Citations: 16     Fields:    Translation:Animals
    100. Cabrol C, Huzarska MA, Dinolfo C, Rodriguez MC, Reinstatler L, Ni J, Yeh LA, Cuny GD, Stein RL, Selkoe DJ, Leissring MA. Small-molecule activators of insulin-degrading enzyme discovered through high-throughput compound screening. PLoS One. 2009; 4(4):e5274. PMID: 19384407; PMCID: PMC2668070.
      Citations: 32     Fields:    Translation:Cells
    101. Laha JK, Petrou P, Cuny GD. One-pot synthesis of alpha-carbolines via sequential palladium-catalyzed aryl amination and intramolecular arylation. J Org Chem. 2009 Apr 17; 74(8):3152-5. PMID: 19323545.
      Citations: 6     Fields:    Translation:Cells
    102. Yu PB, Deng DY, Lai CS, Hong CC, Cuny GD, Bouxsein ML, Hong DW, McManus PM, Katagiri T, Sachidanandan C, Kamiya N, Fukuda T, Mishina Y, Peterson RT, Bloch KD. BMP type I receptor inhibition reduces heterotopic [corrected] ossification. Nat Med. 2008 Dec; 14(12):1363-9. PMID: 19029982; PMCID: PMC2846458.
      Citations: 339     Fields:    Translation:AnimalsCells
    103. Patnaik D, Glicksman MA, Cuny GD, Stein RL, Higgins JM. Identification of small molecule inhibitors of the mitotic kinase haspin by high-throughput screening using a homogeneous time-resolved fluorescence resonance energy transfer assay. J Biomol Screen. 2008 Dec; 13(10):1025-34. PMID: 18978305; PMCID: PMC2615828.
      Citations: 20     Fields:    Translation:HumansCells
    104. Wagle N, Xian J, Shishova EY, Wei J, Glicksman MA, Cuny GD, Stein RL, Cohen DE. Small-molecule inhibitors of phosphatidylcholine transfer protein/StarD2 identified by high-throughput screening. Anal Biochem. 2008 Dec 01; 383(1):85-92. PMID: 18762160; PMCID: PMC2783649.
      Citations: 7     Fields:    Translation:HumansAnimals
    105. Liu M, Choi S, Cuny GD, Ding K, Dobson BC, Glicksman MA, Auerbach K, Stein RL. Kinetic studies of Cdk5/p25 kinase: phosphorylation of tau and complex inhibition by two prototype inhibitors. Biochemistry. 2008 Aug 12; 47(32):8367-77. PMID: 18636751.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    106. Cuny GD, Yu PB, Laha JK, Xing X, Liu JF, Lai CS, Deng DY, Sachidanandan C, Bloch KD, Peterson RT. Structure-activity relationship study of bone morphogenetic protein (BMP) signaling inhibitors. Bioorg Med Chem Lett. 2008 Aug 01; 18(15):4388-92. PMID: 18621530; PMCID: PMC2570262.
      Citations: 179     Fields:    Translation:AnimalsCells
    107. You Z, Savitz SI, Yang J, Degterev A, Yuan J, Cuny GD, Moskowitz MA, Whalen MJ. Necrostatin-1 reduces histopathology and improves functional outcome after controlled cortical impact in mice. J Cereb Blood Flow Metab. 2008 Sep; 28(9):1564-73. PMID: 18493258; PMCID: PMC2831087.
      Citations: 145     Fields:    Translation:Animals
    108. Degterev A, Hitomi J, Germscheid M, Ch'en IL, Korkina O, Teng X, Abbott D, Cuny GD, Yuan C, Wagner G, Hedrick SM, Gerber SA, Lugovskoy A, Yuan J. Identification of RIP1 kinase as a specific cellular target of necrostatins. Nat Chem Biol. 2008 May; 4(5):313-21. PMID: 18408713; PMCID: PMC5434866.
      Citations: 875     Fields:    Translation:Animals
    109. Teng X, Keys H, Yuan J, Degterev A, Cuny GD. Structure-activity relationship and liver microsome stability studies of pyrrole necroptosis inhibitors. Bioorg Med Chem Lett. 2008 Jun 01; 18(11):3219-23. PMID: 18467094; PMCID: PMC2519155.
      Citations: 7     Fields:    Translation:HumansCells
    110. Glicksman MA, Cuny GD, Liu M, Dobson B, Auerbach K, Stein RL, Kosik KS. New approaches to the discovery of cdk5 inhibitors. Curr Alzheimer Res. 2007 Dec; 4(5):547-9. PMID: 18220519.
      Citations: 9     Fields:    Translation:AnimalsCells
    111. Teng X, Keys H, Jeevanandam A, Porco JA, Degterev A, Yuan J, Cuny GD. Structure-activity relationship study of [1,2,3]thiadiazole necroptosis inhibitors. Bioorg Med Chem Lett. 2007 Dec 15; 17(24):6836-40. PMID: 17964153; PMCID: PMC2169518.
      Citations: 11     Fields:    Translation:HumansCells
    112. Mermerian AH, Case A, Stein RL, Cuny GD. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 01; 17(13):3729-32. PMID: 17449248.
      Citations: 29     Fields:    Translation:HumansCells
    113. Jagtap PG, Degterev A, Choi S, Keys H, Yuan J, Cuny GD. Structure-activity relationship study of tricyclic necroptosis inhibitors. J Med Chem. 2007 Apr 19; 50(8):1886-95. PMID: 17361994.
      Citations: 22     Fields:    Translation:HumansCells
    114. Teng X, Cuny GD, Rossi RA, Barolo SM. Syntheses of aporphine and homoaporphine alkaloids by intramolecular ortho-arylation of phenols with aryl halides via SRN1 reactions in liquid ammonia. J Org Chem. 2006 Oct 27; 71(22):8493-9. PMID: 17064025.
      Citations: 3     Fields:    Translation:Cells
    115. Tucker S, Ahl M, Cho HH, Bandyopadhyay S, Cuny GD, Bush AI, Goldstein LE, Westaway D, Huang X, Rogers JT. RNA therapeutics directed to the non coding regions of APP mRNA, in vivo anti-amyloid efficacy of paroxetine, erythromycin, and N-acetyl cysteine. Curr Alzheimer Res. 2006 Jul; 3(3):221-7. PMID: 16842099.
      Citations: 28     Fields:    Translation:AnimalsCells
    116. Nicholson MJ, Moradi B, Seth NP, Xing X, Cuny GD, Stein RL, Wucherpfennig KW. Small molecules that enhance the catalytic efficiency of HLA-DM. J Immunol. 2006 Apr 01; 176(7):4208-20. PMID: 16547258; PMCID: PMC3412064.
      Citations: 28     Fields:    Translation:HumansCells
    117. Zhang D, Xing X, Cuny GD. Synthesis of hydantoins from enantiomerically pure alpha-amino amides without epimerization. J Org Chem. 2006 Feb 17; 71(4):1750-3. PMID: 16468841.
      Citations: 3     Fields:    
    118. Teng X, Degterev A, Jagtap P, Xing X, Choi S, Yuan J, Cuny GD, Denu R. Structure-activity relationship study of novel necroptosis inhibitors. Bioorg Med Chem Lett. 2005 Nov 15; 15(22):5039-44. PMID: 16153840.
      Citations: 69     Fields:    Translation:HumansAnimalsCells
    119. Ahn JS, Radhakrishnan ML, Mapelli M, Choi S, Tidor B, Cuny GD, Musacchio A, Yeh LA, Kosik KS. Defining Cdk5 ligand chemical space with small molecule inhibitors of tau phosphorylation. Chem Biol. 2005 Jul; 12(7):811-23. PMID: 16039528.
      Citations: 21     Fields:    Translation:Cells
    120. Degterev A, Huang Z, Boyce M, Li Y, Jagtap P, Mizushima N, Cuny GD, Mitchison TJ, Moskowitz MA, Yuan J. Chemical inhibitor of nonapoptotic cell death with therapeutic potential for ischemic brain injury. Nat Chem Biol. 2005 Jul; 1(2):112-9. PMID: 16408008.
      Citations: 1087     Fields:    Translation:HumansAnimalsCells
    121. Duval E, Case A, Stein RL, Cuny GD. Structure-activity relationship study of novel tissue transglutaminase inhibitors. Bioorg Med Chem Lett. 2005 Apr 01; 15(7):1885-9. PMID: 15780627.
      Citations: 22     Fields:    Translation:Cells
    122. Yeh LA, Padmanaban D, Ho P, Xing X, Rowley P, Morse LJ, Jensen RV, Cuny GD. Effects of a verbenachalcone derivative on neurite outgrowth, inhibition of caspase induction and gene expression. Bioorg Med Chem Lett. 2005 Feb 15; 15(4):1193-6. PMID: 15686940.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    123. Choi S, Haggart D, Toll L, Cuny GD. Synthesis, receptor binding and functional studies of mesoridazine stereoisomers. Bioorg Med Chem Lett. 2004 Sep 06; 14(17):4379-82. PMID: 15357957.
      Citations: 4     Fields:    Translation:HumansCells
    124. Morse LJ, Payton SM, Cuny GD, Rogers JT. FDA-preapproved drugs targeted to the translational regulation and processing of the amyloid precursor protein. J Mol Neurosci. 2004; 24(1):129-36. PMID: 15314261.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    125. Liu Y, Lashuel HA, Choi S, Xing X, Case A, Ni J, Yeh LA, Cuny GD, Stein RL, Lansbury PT. Discovery of inhibitors that elucidate the role of UCH-L1 activity in the H1299 lung cancer cell line. Chem Biol. 2003 Sep; 10(9):837-46. PMID: 14522054.
      Citations: 106     Fields:    Translation:HumansCells
    126. Oliva B, Miller K, Caggiano N, O'Neill AJ, Cuny GD, Hoemann MZ, Hauske JR, Chopra I. Biological properties of novel antistaphylococcal quinoline-indole agents. Antimicrob Agents Chemother. 2003 Feb; 47(2):458-66. PMID: 12543644; PMCID: PMC151732.
      Citations: 21     Fields:    Translation:AnimalsCells
    127. Hoemann MZ, Xie RL, Rossi RF, Meyer S, Sidhu A, Cuny GD, Hauske JR. Potent in vitro methicillin-resistant Staphylococcus aureus activity of 2-(1H-indol-3-yl)tetrahydroquinoline derivatives. Bioorg Med Chem Lett. 2002 Jan 21; 12(2):129-32. PMID: 11755337.
      Citations: 3     Fields:    Translation:Cells
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