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CHANGYI CHEN

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Surgery
AddressOne Baylor Plaza
Houston, TX 77030
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    Other Positions
    TitleProfessor
    InstitutionBaylor College of Medicine
    DepartmentDepartment of Molecular & Cellular Biology
    DivisionMolecular & Cellular Biology


    Collapse Overview 
    Collapse overview
    Dr. Chen’s laboratory is actively conducting several basic science and translational research projects that are highly relevant to clinical cardiovascular disease and pancreatic cancer.

    Cardiovascular risk factors and their molecular mechanisms in cardiovascular disease

    We are investigating the effects and the molecular mechanisms of several cardiovascular risk factors, including HIV protease inhibitors, the adipokine resistin, soluble CD40L, and uric acid, on biochemical pathways associated with endothelial cell functions. Some of the biochemical pathways under investigation are the endothelial nitric oxide synthase system, the oxidative stress system, and signal transduction pathways. We are carrying on these investigations using several experimental models, such as myographies, organ cultures, mouse models, human tissue samples, and different types of endothelial cells. Based on the molecular mechanisms we uncover, we develop effective therapeutic strategies to treat endothelial dysfunction and atherosclerosis.

    Endothelial cell differentiation and angiogenesis

    We are studying the role played by and the molecular mechanisms of hemodynamic factors and several novel molecules on endothelial cells differentiated from embryonic stem cells and from bone marrow-derived stem cells. We are identifying key regulatory genes that trigger endothelial cell differentiation and promote stable angiogenesis. These findings can potentially be applied to the design of novel therapeutic strategies to treat ischemic tissues using genetically engineered endothelial cells. In addition, these studies may provide useful information to genetically engineer novel tissues for vascular grafts.

    Pancreatic cancer

    We have been heavily involved in pancreatic cancer research programs for many years. We have several projects focusing on the role and on the mechanisms of several genes, such as microRNA
    196a (miR-196a), X-inactive specific transcript (XIST), and Jude-2 in pancreatic cancer. Our comprehensive studies analyze human cancer specimens, clinical outcomes, established cell
    lines, a nude mouse model, and a genetically engineered mouse model of pancreatic cancer called the KPC model. We are developing PLGA [poly(lactic-co-glycolic acid)]-based nanotechnology for molecular imaging and for specific drug and gene delivery, which has great potential clinical applications, such as molecular diagnostics and targeted therapies.

    Collapse Research 
    Collapse research activities and funding
    R21AR063017     (CHEN, CHANGYI)Apr 1, 2013 - Mar 31, 2016
    NIH
    Natural Substance Derivative DHNB is A Novel Xanthine Oxidase Inhibitor
    Role: Principal Investigator
    T32HL083774     (CHEN, CHANGYI)Sep 1, 2008 - Apr 16, 2015
    NIH
    Molecular Surgeon Research Training on Vascular Disease
    Role: Principal Investigator
    R13CA132572     (CHEN, CHANGYI)Mar 1, 2008 - Feb 28, 2009
    NIH
    Molecular Surgeon Symposium on Genetics and Genomics of Pancreatic Cancer
    Role: Principal Investigator
    R13HL083650     (CHEN, CHANGYI)Sep 30, 2005 - Aug 31, 2007
    NIH
    Molecular Surgeon Symposium on Vascular Injury, Repair
    Role: Principal Investigator
    R01HL083471     (CHEN, CHANGYI)Sep 29, 2005 - Jun 30, 2013
    NIH
    Effects of HAART drugs on endothelial dysfunction of pu*
    Role: Principal Investigator
    R01EB002436     (CHEN, CHANGYI)Sep 20, 2003 - Jul 31, 2008
    NIH
    Tissue engineering of small diameter vascular graft
    Role: Principal Investigator
    R01HL072716     (CHEN, CHANGYI)Sep 30, 2002 - Jul 31, 2007
    NIH
    Effects of HIV Protease Inhibitors of Endothelial Barrie
    Role: Principal Investigator
    R01HL065916     (CHEN, CHANGYI)Sep 15, 2000 - Aug 31, 2007
    NIH
    HIV PROTEASE INHIBITORS EFFECT--NENDOTHELIAL DYSFUNCTION
    Role: Principal Investigator
    R01HL061943     (CHEN, CHANGYI)Sep 20, 1998 - Jul 31, 2005
    NIH
    HIV/SIV ENVELOPE GLYCOPROTEIN EFFECTS ON ENDOTHELIA
    Role: Principal Investigator
    R01HL060135     (CHEN, CHANGYI)Aug 14, 1998 - Jul 31, 2004
    NIH
    ANGIOTENSIN II AND REGULATION OF MCP-1 GENE EXPRESSION
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Wang L, Zhao M, Li S, Erasquin UJ, Wang H, Ren L, Chen C, Wang Y, Cai C. "Click" immobilization of a VEGF-mimetic peptide on decellularized endothelial extracellular matrix to enhance angiogenesis. ACS Appl Mater Interfaces. 2014 Jun 11; 6(11):8401-6. PMID: 24749832; PMCID: PMC4059262.
      Citations: 13     Fields:    Translation:HumansCells
    2. Jamaluddin MS, Liang Z, Lu JM, Yao Q, Chen C. Roles of cardiovascular risk factors in endothelial nitric oxide synthase regulation: an update. Curr Pharm Des. 2014; 20(22):3563-78. PMID: 24180390.
      Citations: 4     Fields:    Translation:HumansCells
    3. Chen C, Liao D, Wang J, Liang Z, Yao Q. Anti-human protein S antibody induces tissue factor expression through a direct interaction with platelet phosphofructokinase. Thromb Res. 2014 Feb; 133(2):222-8. PMID: 24331211; PMCID: PMC3947162.
      Citations: 3     Fields:    Translation:HumansCells
    4. Fang Y, Yao Q, Chen Z, Xiang J, William FE, Gibbs RA, Chen C. Genetic and molecular alterations in pancreatic cancer: implications for personalized medicine. Med Sci Monit. 2013 Oct 31; 19:916-26. PMID: 24172537; PMCID: PMC3818103.
      Citations: 23     Fields:    Translation:Humans
    5. Brunner G, Yang EY, Kumar A, Sun W, Virani SS, Negi SI, Murray T, Lin PH, Hoogeveen RC, Chen C, Dong JF, Kougias P, Taylor A, Lumsden AB, Nambi V, Ballantyne CM, Morrisett JD. The Effect of Lipid Modification on Peripheral Artery Disease after Endovascular Intervention Trial (ELIMIT). Atherosclerosis. 2013 Dec; 231(2):371-7. PMID: 24267254; PMCID: PMC4545656.
      Citations: 10     Fields:    Translation:Humans
    6. Sribenja S, Sawanyawisuth K, Kraiklang R, Wongkham C, Vaeteewoottacharn K, Obchoei S, Yao Q, Wongkham S, Chen C. Suppression of thymosin ?10 increases cell migration and metastasis of cholangiocarcinoma. BMC Cancer. 2013 Sep 23; 13:430. PMID: 24053380; PMCID: PMC3849271.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    7. Yao Q, Chen C, L? JM. 3,4-Dihydroxy-5-nitrobenzaldehyde (DHNB) is a potent inhibitor of xanthine oxidase: a potential therapeutic agent for treatment of hyperuricemia and gout. Biochem Pharmacol. 2013 Nov 01; 86(9):1328-37. PMID: 23994369; PMCID: PMC3816736.
      Citations: 10     Fields:    Translation:AnimalsCells
    8. Marin-Muller C, Li D, Bharadwaj U, Li M, Chen C, Hodges SE, Fisher WE, Mo Q, Hung MC, Yao Q. A tumorigenic factor interactome connected through tumor suppressor microRNA-198 in human pancreatic cancer. Clin Cancer Res. 2013 Nov 01; 19(21):5901-13. PMID: 23989979; PMCID: PMC3920728.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    9. Zhang Y, Yang J, Cui X, Chen Y, Zhu VF, Hagan JP, Wang H, Yu X, Hodges SE, Fang J, Chiao PJ, Logsdon CD, Fisher WE, Brunicardi FC, Chen C, Yao Q, Fernandez-Zapico ME, Li M. A novel epigenetic CREB-miR-373 axis mediates ZIP4-induced pancreatic cancer growth. EMBO Mol Med. 2013 Sep; 5(9):1322-34. PMID: 23857777; PMCID: PMC3799489.
      Citations: 50     Fields:    Translation:HumansAnimalsCells
    10. Zhang S, Yong LK, Li D, Cubas R, Chen C, Yao Q. Mesothelin virus-like particle immunization controls pancreatic cancer growth through CD8+ T cell induction and reduction in the frequency of CD4+ foxp3+ ICOS- regulatory T cells. PLoS One. 2013; 8(7):e68303. PMID: 23874581; PMCID: PMC3706370.
      Citations: 18     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    11. Zhang S, Li F, Younes M, Liu H, Chen C, Yao Q. Reduced selenium-binding protein 1 in breast cancer correlates with poor survival and resistance to the anti-proliferative effects of selenium. PLoS One. 2013; 8(5):e63702. PMID: 23704933; PMCID: PMC3660592.
      Citations: 28     Fields:    Translation:HumansCells
    12. Sribenja S, Wongkham S, Wongkham C, Yao Q, Chen C. Roles and mechanisms of ?-thymosins in cell migration and cancer metastasis: an update. Cancer Invest. 2013 Feb; 31(2):103-10. PMID: 23320791.
      Citations: 28     Fields:    Translation:HumansAnimals
    13. Yan S, Jamaluddin S, Weakley SM, Liang Z, Siwak EB, Yao Q, Chen C, L? JM. Ginkgolic acid inhibits HIV protease activity and HIV infection in vitro. Med Sci Monit. 2012 Aug; 18(8):BR293-298. PMID: 22847190; PMCID: PMC3560711.
      Citations: 24     Fields:    Translation:HumansCells
    14. Chen C, Ochoa LN, Kagan A, Chai H, Liang Z, Lin PH, Yao Q. Lysophosphatidic acid causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Atherosclerosis. 2012 May; 222(1):74-83. PMID: 22424734; PMCID: PMC3334473.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    15. Jamaluddin MS, Weakley SM, Yao Q, Chen C. Resistin: functional roles and therapeutic considerations for cardiovascular disease. Br J Pharmacol. 2012 Feb; 165(3):622-32. PMID: 21545576; PMCID: PMC3315035.
      Citations: 128     Fields:    Translation:HumansAnimalsCells
    16. Weakley SM, Yang Z, Hu M, Yao Q, Chen C, L? JM. Ginsenoside Rb1 directly scavenges hydroxyl radical and hypochlorous acid. Curr Pharm Des. 2012; 18(38):6339-47. PMID: 22974003.
      Citations: 20     Fields:    Translation:Cells
    17. Nurko J, Jiang J, Weakley SM, Lin PH, Yao Q, Chen C, L? JM. Nordihydroguaiaretic acid (NDGA) inhibits ritonavir-induced endothelial dysfunction in porcine pulmonary arteries. Med Sci Monit. 2011 Nov; 17(11):BR312-318. PMID: 22037733; PMCID: PMC3275091.
      Citations: 2     Fields:    Translation:Animals
    18. Weakley SM, Jiang J, Wang X, Lin PH, Yao Q, Chen C, L? J. Natural antioxidant dihydroxybenzyl alcohol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human endothelial cells. Med Sci Monit. 2011 Sep; 17(9):BR235-41. PMID: 21873935; PMCID: PMC3273316.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    19. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin confers pancreatic cancer cell resistance to TNF-a-induced apoptosis through Akt/PI3K/NF-?B activation and IL-6/Mcl-1 overexpression. Mol Cancer. 2011 Aug 31; 10:106. PMID: 21880146; PMCID: PMC3175472.
      Citations: 55     Fields:    Translation:HumansCells
    20. Obchoei S, Weakley SM, Wongkham S, Wongkham C, Sawanyawisuth K, Yao Q, Chen C. Cyclophilin A enhances cell proliferation and tumor growth of liver fluke-associated cholangiocarcinoma. Mol Cancer. 2011 Aug 26; 10:102. PMID: 21871105; PMCID: PMC3173387.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    21. Brunicardi FC, Gibbs RA, Wheeler DA, Nemunaitis J, Fisher W, Goss J, Chen C. Overview of the development of personalized genomic medicine and surgery. World J Surg. 2011 Aug; 35(8):1693-9. PMID: 21424870; PMCID: PMC3281749.
      Citations: 8     Fields:    Translation:Humans
    22. Weakley SM, Wang H, Yao Q, Chen C. Expression and function of a large non-coding RNA gene XIST in human cancer. World J Surg. 2011 Aug; 35(8):1751-6. PMID: 21212949; PMCID: PMC3275083.
      Citations: 71     Fields:    Translation:HumansAnimalsCells
    23. Zhang L, Jamaluddin MS, Weakley SM, Yao Q, Chen C. Roles and mechanisms of microRNAs in pancreatic cancer. World J Surg. 2011 Aug; 35(8):1725-31. PMID: 21222121; PMCID: PMC3275100.
      Citations: 19     Fields:    Translation:Humans
    24. Balentine CJ, Berger DH, Liu SH, Chen C, Nemunaitis J, Brunicardi FC. Defining the cancer master switch. World J Surg. 2011 Aug; 35(8):1738-45. PMID: 21286716.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    25. Bharadwaj U, Marin-Muller C, Li M, Chen C, Yao Q. Mesothelin overexpression promotes autocrine IL-6/sIL-6R trans-signaling to stimulate pancreatic cancer cell proliferation. Carcinogenesis. 2011 Jul; 32(7):1013-24. PMID: 21515913; PMCID: PMC3128561.
      Citations: 43     Fields:    Translation:HumansCells
    26. Weakley SM, Wang X, Mu H, Lin PH, Yao Q, Chen C, L? J. Ginkgolide A-gold nanoparticles inhibit vascular smooth muscle proliferation and migration in vitro and reduce neointimal hyperplasia in a mouse model. J Surg Res. 2011 Nov; 171(1):31-9. PMID: 21571322; PMCID: PMC3161135.
      Citations: 8     Fields:    Translation:AnimalsCells
    27. Cubas R, Zhang S, Li M, Chen C, Yao Q. Chimeric Trop2 virus-like particles: a potential immunotherapeutic approach against pancreatic cancer. J Immunother. 2011 Apr; 34(3):251-63. PMID: 21389873.
      Citations: 20     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    28. Long J, Zhang Y, Yu X, Yang J, LeBrun DG, Chen C, Yao Q, Li M. Overcoming drug resistance in pancreatic cancer. Expert Opin Ther Targets. 2011 Jul; 15(7):817-28. PMID: 21391891; PMCID: PMC3111812.
      Citations: 95     Fields:    Translation:HumansCells
    29. Yang H, Zhang L, Weakley SM, Lin PH, Yao Q, Chen C. Transforming growth factor-beta increases the expression of vascular smooth muscle cell markers in human multi-lineage progenitor cells. Med Sci Monit. 2011 Feb 25; 17(3):BR55-61. PMID: 21358594; PMCID: PMC3276078.
      Citations: 5     Fields:    Translation:HumansCells
    30. Chen C, Zhang Y, Zhang L, Weakley SM, Yao Q. MicroRNA-196: critical roles and clinical applications in development and cancer. J Cell Mol Med. 2011 Jan; 15(1):14-23. PMID: 21091634; PMCID: PMC3276076.
      Citations: 92     Fields:    Translation:HumansAnimals
    31. Jamaluddin MS, Weakley SM, Zhang L, Kougias P, Lin PH, Yao Q, Chen C. miRNAs: roles and clinical applications in vascular disease. Expert Rev Mol Diagn. 2011 Jan; 11(1):79-89. PMID: 21171923; PMCID: PMC3077058.
      Citations: 44     Fields:    Translation:HumansCells
    32. Liu SH, Patel S, Gingras MC, Nemunaitis J, Zhou G, Chen C, Li M, Fisher W, Gibbs R, Brunicardi FC. PDX-1: demonstration of oncogenic properties in pancreatic cancer. Cancer. 2011 Feb 15; 117(4):723-33. PMID: 20886630; PMCID: PMC3017729.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    33. Cubas R, Zhang S, Li M, Chen C, Yao Q. Trop2 expression contributes to tumor pathogenesis by activating the ERK MAPK pathway. Mol Cancer. 2010 Sep 21; 9:253. PMID: 20858281; PMCID: PMC2946292.
      Citations: 77     Fields:    Translation:HumansAnimalsCells
    34. Wang D, Xu X, Deng X, Chen C, Li B, Tan H, Wang H, Tang S, Qiu H, Chen J, Ke B, Ke C, Kan B. Detection of Vibrio cholerae O1 and O139 in environmental water samples by an immunofluorescent-aggregation assay. Appl Environ Microbiol. 2010 Aug; 76(16):5520-5. PMID: 20581193; PMCID: PMC2918967.
      Citations: 9     Fields:    Translation:CellsPHPublic Health
    35. Zhang R, Zhang S, Li M, Chen C, Yao Q. Incorporation of CD40 ligand into SHIV virus-like particles (VLP) enhances SHIV-VLP-induced dendritic cell activation and boosts immune responses against HIV. Vaccine. 2010 Jul 12; 28(31):5114-27. PMID: 20471443; PMCID: PMC2906648.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    36. Nurko J, Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Chen C, L? JM. Molecular mechanisms and clinical applications of nordihydroguaiaretic acid (NDGA) and its derivatives: an update. Med Sci Monit. 2010 May; 16(5):RA93-100. PMID: 20424564; PMCID: PMC2927326.
      Citations: 60     Fields:    Translation:HumansAnimals
    37. Chen C, Jiang J, Chai H, Wang X, Lin PH, Yao Q, L? JM. Resistin decreases expression of endothelial nitric oxide synthase through oxidative stress in human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2010 Jul; 299(1):H193-201. PMID: 20435848; PMCID: PMC2904138.
      Citations: 62     Fields:    Translation:HumansCells
    38. Weakley SM, Jiang J, Kougias P, Lin PH, Yao Q, Brunicardi FC, Gibbs RA, Chen C. Role of somatic mutations in vascular disease formation. Expert Rev Mol Diagn. 2010 Mar; 10(2):173-85. PMID: 20214536; PMCID: PMC2920047.
      Citations: 11     Fields:    Translation:Humans
    39. Zhang Y, Chen C, Yao Q, Li M. ZIP4 upregulates the expression of neuropilin-1, vascular endothelial growth factor, and matrix metalloproteases in pancreatic cancer cell lines and xenografts. Cancer Biol Ther. 2010 Feb; 9(3):236-42. PMID: 20023433; PMCID: PMC2896555.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    40. Zhang Y, Bharadwaj U, Logsdon CD, Chen C, Yao Q, Li M. ZIP4 regulates pancreatic cancer cell growth by activating IL-6/STAT3 pathway through zinc finger transcription factor CREB. Clin Cancer Res. 2010 Mar 01; 16(5):1423-30. PMID: 20160059; PMCID: PMC2841320.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    41. Jiang J, Fu W, Wang X, Lin PH, Yao Q, Chen C. HIV gp120 induces endothelial dysfunction in tumour necrosis factor-alpha-activated porcine and human endothelial cells. Cardiovasc Res. 2010 Jul 15; 87(2):366-74. PMID: 20083573; PMCID: PMC2895538.
      Citations: 27     Fields:    Translation:HumansAnimalsCells
    42. Kougias P, Weakley SM, Yao Q, Lin PH, Chen C. Arterial baroreceptors in the management of systemic hypertension. Med Sci Monit. 2010 Jan; 16(1):RA1-8. PMID: 20037502; PMCID: PMC2921195.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    43. Sribenja S, Li M, Wongkham S, Wongkham C, Yao Q, Chen C. Advances in thymosin beta10 research: differential expression, molecular mechanisms, and clinical implications in cancer and other conditions. Cancer Invest. 2009 Dec; 27(10):1016-22. PMID: 19909017.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    44. Cheng C, Wang X, Weakley SM, Kougias P, Lin PH, Yao Q, Chen C. The soybean isoflavonoid equol blocks ritonavir-induced endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. J Nutr. 2010 Jan; 140(1):12-7. PMID: 19923382; PMCID: PMC2793119.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    45. Obchoei S, Wongkhan S, Wongkham C, Li M, Yao Q, Chen C. Cyclophilin A: potential functions and therapeutic target for human cancer. Med Sci Monit. 2009 Nov; 15(11):RA221-32. PMID: 19865066.
      Citations: 36     Fields:    Translation:Humans
    46. Yu X, Zhang Y, Chen C, Yao Q, Li M. Targeted drug delivery in pancreatic cancer. Biochim Biophys Acta. 2010 Jan; 1805(1):97-104. PMID: 19853645; PMCID: PMC2815202.
      Citations: 25     Fields:    Translation:Humans
    47. Jamaluddin MS, Wang X, Wang H, Rafael C, Yao Q, Chen C. Eotaxin increases monolayer permeability of human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2009 Dec; 29(12):2146-52. PMID: 19778943; PMCID: PMC2784176.
      Citations: 15     Fields:    Translation:HumansCells
    48. Wang X, Liao D, Lin PH, Yao Q, Chen C. Highly active antiretroviral therapy drugs inhibit in vitro cholesterol efflux from human macrophage-derived foam cells. Lab Invest. 2009 Dec; 89(12):1355-63. PMID: 19770838; PMCID: PMC2787635.
      Citations: 6     Fields:    Translation:HumansCells
    49. Li M, Zhang Y, Bharadwaj U, Zhai QJ, Ahern CH, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Down-regulation of ZIP4 by RNA interference inhibits pancreatic cancer growth and increases the survival of nude mice with pancreatic cancer xenografts. Clin Cancer Res. 2009 Oct 01; 15(19):5993-6001. PMID: 19755388; PMCID: PMC2756333.
      Citations: 53     Fields:    Translation:HumansAnimalsCells
    50. Lin PH, Yao Q, Chen C, L? JM. Chemical and molecular mechanisms of antioxidants: experimental approaches and model systems. J Cell Mol Med. 2010 Apr; 14(4):840-60. PMID: 19754673; PMCID: PMC2927345.
      Citations: 226     Fields:    Translation:HumansAnimalsCells
    51. Bismuth J, Chai H, Lin PH, Yao Q, Chen C. Lactosylceramide causes endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Med Sci Monit. 2009 Sep; 15(9):BR270-4. PMID: 19721395; PMCID: PMC2927961.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    52. Cubas R, Li M, Chen C, Yao Q. Trop2: a possible therapeutic target for late stage epithelial carcinomas. Biochim Biophys Acta. 2009 Dec; 1796(2):309-14. PMID: 19683559.
      Citations: 61     Fields:    Translation:HumansAnimalsCells
    53. Liao D, Wang X, Lin PH, Yao Q, Chen C. Covalent linkage of heparin provides a stable anti-coagulation surface of decellularized porcine arteries. J Cell Mol Med. 2009 Aug; 13(8B):2736-2743. PMID: 19040421; PMCID: PMC2830292.
      Citations: 9     Fields:    Translation:Animals
    54. Jamaluddin MS, Lin PH, Yao Q, Chen C. Non-nucleoside reverse transcriptase inhibitor efavirenz increases monolayer permeability of human coronary artery endothelial cells. Atherosclerosis. 2010 Jan; 208(1):104-11. PMID: 19674747; PMCID: PMC2813420.
      Citations: 12     Fields:    Translation:HumansCells
    55. Yao Q, Chen C, L? JM. Ginseng compounds: an update on their molecular mechanisms and medical applications. Curr Vasc Pharmacol. 2009 Jul; 7(3):293-302. PMID: 19601854; PMCID: PMC2928028.
      Citations: 206     Fields:    Translation:HumansAnimalsCells
    56. Mu H, Wang X, Wang H, Lin P, Yao Q, Chen C. Lactosylceramide promotes cell migration and proliferation through activation of ERK1/2 in human aortic smooth muscle cells. Am J Physiol Heart Circ Physiol. 2009 Jul; 297(1):H400-8. PMID: 19465542.
      Citations: 14     Fields:    Translation:HumansCells
    57. Chen C, Chai H, Wang X, Lin PH, Yao Q. Chlamydia heat shock protein 60 decreases expression of endothelial nitric oxide synthase in human and porcine coronary artery endothelial cells. Cardiovasc Res. 2009 Sep 01; 83(4):768-77. PMID: 19443423; PMCID: PMC2725775.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    58. Wang X, Marin-Muller C, Wang H, Lin PH, Yao Q, Chen C, L? JM. Current advances in research and clinical applications of PLGA-based nanotechnology. Expert Rev Mol Diagn. 2009 May; 9(4):325-41. PMID: 19435455; PMCID: PMC2701163.
      Citations: 219     Fields:    Translation:HumansAnimals
    59. Nambi V, Kimball KT, Bray PF, Bergeron AL, Johnson SL, Morrisett JD, Chen C, Lin PH, Lumsden AB, Ballantyne CM, Dong JF. Differences in responses of platelets to fluid shear stress in patients with peripheral artery disease (PAD) and coronary artery disease (CAD). Platelets. 2009 May; 20(3):199-205. PMID: 19437338; PMCID: PMC2869211.
      Citations: 5     Fields:    Translation:Humans
    60. Zhang S, Cubas R, Li M, Chen C, Yao Q. Virus-like particle vaccine activates conventional B2 cells and promotes B cell differentiation to IgG2a producing plasma cells. Mol Immunol. 2009 Jun; 46(10):1988-2001. PMID: 19376580; PMCID: PMC2702656.
      Citations: 21     Fields:    Translation:AnimalsCellsPHPublic Health
    61. Voidonikolas G, Kreml SS, Chen C, Fisher WE, Brunicardi FC, Gibbs RA, Gingras MC. Basic principles and technologies for deciphering the genetic map of cancer. World J Surg. 2009 Apr; 33(4):615-29. PMID: 19115029; PMCID: PMC2924149.
      Citations: 10     Fields:    Translation:Humans
    62. Voidonikolas G, Gingras MC, Hodges S, McGuire AL, Chen C, Gibbs RA, Brunicardi FC, Fisher WE. Developing a tissue resource to characterize the genome of pancreatic cancer. World J Surg. 2009 Apr; 33(4):723-31. PMID: 19137368; PMCID: PMC2925468.
      Citations: 7     Fields:    Translation:Humans
    63. Li M, Marin-Muller C, Bharadwaj U, Chow KH, Yao Q, Chen C. MicroRNAs: control and loss of control in human physiology and disease. World J Surg. 2009 Apr; 33(4):667-84. PMID: 19030926; PMCID: PMC2933043.
      Citations: 76     Fields:    Translation:Humans
    64. Zhang Y, Li M, Wang H, Fisher WE, Lin PH, Yao Q, Chen C. Profiling of 95 microRNAs in pancreatic cancer cell lines and surgical specimens by real-time PCR analysis. World J Surg. 2009 Apr; 33(4):698-709. PMID: 19030927; PMCID: PMC2933040.
      Citations: 143     Fields:    Translation:HumansCells
    65. Marin-Muller C, Li M, Chen C, Yao Q. Current understanding and potential immunotherapy for HIV-associated squamous cell carcinoma of the anus (SCCA). World J Surg. 2009 Apr; 33(4):653-60. PMID: 19052810; PMCID: PMC2924142.
      Citations: 3     Fields:    Translation:Humans
    66. Brunicardi FC, Gibbs RA, Fisher W, Chen C. Overview of the Molecular Surgeon Symposium on Personalized Genomic Medicine and Surgery. World J Surg. 2009 Apr; 33(4):612-4. PMID: 19083052.
      Citations: 5     Fields:    Translation:Humans
    67. Duffy P, Wang X, Lin PH, Yao Q, Chen C. HIV Nef protein causes endothelial dysfunction in porcine pulmonary arteries and human pulmonary artery endothelial cells. J Surg Res. 2009 Oct; 156(2):257-64. PMID: 19540523; PMCID: PMC2760402.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    68. Li M, Zhang Y, Zhai Q, Feurino LW, Fisher WE, Chen C, Yao Q. Thymosin beta-10 is aberrantly expressed in pancreatic cancer and induces JNK activation. Cancer Invest. 2009 Mar; 27(3):251-6. PMID: 19194824; PMCID: PMC2929368.
      Citations: 9     Fields:    Translation:HumansCells
    69. Wang X, Chai H, Lin PH, Yao Q, Chen C. Roles and mechanisms of human immunodeficiency virus protease inhibitor ritonavir and other anti-human immunodeficiency virus drugs in endothelial dysfunction of porcine pulmonary arteries and human pulmonary artery endothelial cells. Am J Pathol. 2009 Mar; 174(3):771-81. PMID: 19218343; PMCID: PMC2665739.
      Citations: 36     Fields:    Translation:Animals
    70. Cubas R, Zhang S, Kwon S, Sevick-Muraca EM, Li M, Chen C, Yao Q. Virus-like particle (VLP) lymphatic trafficking and immune response generation after immunization by different routes. J Immunother. 2009 Feb-Mar; 32(2):118-28. PMID: 19238010; PMCID: PMC2717166.
      Citations: 56     Fields:    Translation:AnimalsCellsPHPublic Health
    71. Dhadwal AK, Wang X, Annambhotla S, Lin PH, Yao Q, Chen C. Capsaicin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine pulmonary arteries. Med Sci Monit. 2009 Jan; 15(1):BR1-5. PMID: 19114959; PMCID: PMC2932636.
      Citations: 5     Fields:    Translation:Animals
    72. Zhang Y, Li M, Yao Q, Chen C. Roles and mechanisms of copper transporting ATPases in cancer pathogenesis. Med Sci Monit. 2009 Jan; 15(1):RA1-5. PMID: 19114980.
      Citations: 10     Fields:    Translation:Humans
    73. Hedayati N, Annambhotla S, Jiang J, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growth hormone-releasing peptide ghrelin inhibits homocysteine-induced endothelial dysfunction in porcine coronary arteries and human endothelial cells. J Vasc Surg. 2009 Jan; 49(1):199-207. PMID: 19028051; PMCID: PMC2652132.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    74. Bharadwaj U, Li M, Chen C, Yao Q. Mesothelin-induced pancreatic cancer cell proliferation involves alteration of cyclin E via activation of signal transducer and activator of transcription protein 3. Mol Cancer Res. 2008 Nov; 6(11):1755-65. PMID: 19010822; PMCID: PMC2929833.
      Citations: 49     Fields:    Translation:HumansCells
    75. Wang X, Chai H, Wang Z, Lin PH, Yao Q, Chen C. Serum amyloid A induces endothelial dysfunction in porcine coronary arteries and human coronary artery endothelial cells. Am J Physiol Heart Circ Physiol. 2008 Dec; 295(6):H2399-408. PMID: 18931033; PMCID: PMC2614654.
      Citations: 25     Fields:    Translation:HumansAnimalsCells
    76. Liao D, Wang X, Li M, Lin PH, Yao Q, Chen C. Human protein S inhibits the uptake of AcLDL and expression of SR-A through Mer receptor tyrosine kinase in human macrophages. Blood. 2009 Jan 01; 113(1):165-74. PMID: 18922854; PMCID: PMC2614630.
      Citations: 12     Fields:    Translation:HumansCells
    77. Li M, Wang X, Li W, Li F, Yang H, Wang H, Brunicardi FC, Chen C, Yao Q, Fisher WE. Somatostatin receptor-1 induces cell cycle arrest and inhibits tumor growth in pancreatic cancer. Cancer Sci. 2008 Nov; 99(11):2218-23. PMID: 18823376; PMCID: PMC2930023.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    78. Chen C, Chai H, Wang X, Jiang J, Jamaluddin MS, Liao D, Zhang Y, Wang H, Bharadwaj U, Zhang S, Li M, Lin P, Yao Q. Soluble CD40 ligand induces endothelial dysfunction in human and porcine coronary artery endothelial cells. Blood. 2008 Oct 15; 112(8):3205-16. PMID: 18658029; PMCID: PMC2569174.
      Citations: 31     Fields:    Translation:HumansAnimalsCells
    79. Liao D, Lin PH, Yao Q, Chen C. Vascular smooth cell proliferation in perfusion culture of porcine carotid arteries. Biochem Biophys Res Commun. 2008 Aug 08; 372(4):668-73. PMID: 18515073; PMCID: PMC2925440.
      Citations: 2     Fields:    Translation:AnimalsCells
    80. Annambhotla S, Bourgeois S, Wang X, Lin PH, Yao Q, Chen C. Recent advances in molecular mechanisms of abdominal aortic aneurysm formation. World J Surg. 2008 Jun; 32(6):976-86. PMID: 18259804; PMCID: PMC2927355.
      Citations: 20     Fields:    Translation:HumansAnimals
    81. Mu H, Wang X, Lin P, Yao Q, Chen C. Nitrotyrosine promotes human aortic smooth muscle cell migration through oxidative stress and ERK1/2 activation. Biochim Biophys Acta. 2008 Sep; 1783(9):1576-84. PMID: 18460343; PMCID: PMC2927358.
      Citations: 6     Fields:    Translation:HumansCells
    82. Huang C, Li M, Chen C, Yao Q. Small interfering RNA therapy in cancer: mechanism, potential targets, and clinical applications. Expert Opin Ther Targets. 2008 May; 12(5):637-45. PMID: 18410245.
      Citations: 42     Fields:    Translation:HumansAnimals
    83. Zhang Y, Chen AY, Li M, Chen C, Yao Q. Ginkgo biloba extract kaempferol inhibits cell proliferation and induces apoptosis in pancreatic cancer cells. J Surg Res. 2008 Jul; 148(1):17-23. PMID: 18570926; PMCID: PMC2924764.
      Citations: 35     Fields:    Translation:HumansAnimalsCells
    84. Dominguez EP, Barshes NR, Sherman V, Albo D, Kougias P, Chen C, Sweeney JF, Lin PH. Effect of catheter-directed arterial embolization and laparoscopic endovascular stapling on stapled vessel integrity in a porcine model. Vascular. 2008 Mar-Apr; 16(2):80-4. PMID: 18377836.
      Citations:    Fields:    Translation:Animals
    85. Chen C, Jamaluddin MS, Yan S, Sheikh-Hamad D, Yao Q. Human stanniocalcin-1 blocks TNF-alpha-induced monolayer permeability in human coronary artery endothelial cells. Arterioscler Thromb Vasc Biol. 2008 May; 28(5):906-12. PMID: 18309109; PMCID: PMC2731718.
      Citations: 30     Fields:    Translation:HumansCells
    86. Li M, Zhang Y, Feurino LW, Wang H, Fisher WE, Brunicardi FC, Chen C, Yao Q. Interleukin-8 increases vascular endothelial growth factor and neuropilin expression and stimulates ERK activation in human pancreatic cancer. Cancer Sci. 2008 Apr; 99(4):733-7. PMID: 18307536; PMCID: PMC2930017.
      Citations: 42     Fields:    Translation:HumansCells
    87. Mu H, Wang X, Lin PH, Yao Q, Chen C. Chlorotyrosine promotes human aortic smooth muscle cell migration through increasing superoxide anion production and ERK1/2 activation. Atherosclerosis. 2008 Nov; 201(1):67-75. PMID: 18281051; PMCID: PMC2924162.
      Citations: 10     Fields:    Translation:HumansCells
    88. Li M, Bharadwaj U, Zhang R, Zhang S, Mu H, Fisher WE, Brunicardi FC, Chen C, Yao Q. Mesothelin is a malignant factor and therapeutic vaccine target for pancreatic cancer. Mol Cancer Ther. 2008 Feb; 7(2):286-96. PMID: 18281514; PMCID: PMC2929838.
      Citations: 90     Fields:    Translation:HumansAnimalsCells
    89. Wang H, Li M, Lin PH, Yao Q, Chen C. Fluid shear stress regulates the expression of TGF-beta1 and its signaling molecules in mouse embryo mesenchymal progenitor cells. J Surg Res. 2008 Dec; 150(2):266-70. PMID: 18547588; PMCID: PMC2927960.
      Citations: 8     Fields:    Translation:AnimalsCells
    90. Wang X, Liao D, Bharadwaj U, Li M, Yao Q, Chen C. C-reactive protein inhibits cholesterol efflux from human macrophage-derived foam cells. Arterioscler Thromb Vasc Biol. 2008 Mar; 28(3):519-26. PMID: 18096828; PMCID: PMC2927966.
      Citations: 24     Fields:    Translation:HumansCells
    91. Zhang Y, Feurino LW, Zhai Q, Wang H, Fisher WE, Chen C, Yao Q, Li M. Thymosin Beta 4 is overexpressed in human pancreatic cancer cells and stimulates proinflammatory cytokine secretion and JNK activation. Cancer Biol Ther. 2008 Mar; 7(3):419-23. PMID: 18094619; PMCID: PMC2930015.
      Citations: 18     Fields:    Translation:HumansCells
    92. Li M, Zhang Y, Liu Z, Bharadwaj U, Wang H, Wang X, Zhang S, Liuzzi JP, Chang SM, Cousins RJ, Fisher WE, Brunicardi FC, Logsdon CD, Chen C, Yao Q. Aberrant expression of zinc transporter ZIP4 (SLC39A4) significantly contributes to human pancreatic cancer pathogenesis and progression. Proc Natl Acad Sci U S A. 2007 Nov 20; 104(47):18636-41. PMID: 18003899; PMCID: PMC2141829.
      Citations: 127     Fields:    Translation:HumansAnimalsCells
    93. Bismuth J, Lin P, Yao Q, Chen C. Ceramide: a common pathway for atherosclerosis? Atherosclerosis. 2008 Feb; 196(2):497-504. PMID: 17963772; PMCID: PMC2924671.
      Citations: 64     Fields:    Translation:Humans
    94. Chen C, Nan B, Lin P, Yao Q. C-reactive protein increases plasminogen activator inhibitor-1 expression in human endothelial cells. Thromb Res. 2008; 122(1):125-33. PMID: 17949793; PMCID: PMC2925432.
      Citations: 16     Fields:    Translation:HumansCells
    95. Zhang Y, Li M, Yao Q, Chen C. Recent advances in tumor hypoxia: tumor progression, molecular mechanisms, and therapeutic implications. Med Sci Monit. 2007 Oct; 13(10):RA175-80. PMID: 17901861.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    96. Bechara C, Wang X, Chai H, Lin PH, Yao Q, Chen C. Growth-related oncogene-alpha induces endothelial dysfunction through oxidative stress and downregulation of eNOS in porcine coronary arteries. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H3088-95. PMID: 17873023.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    97. Feurino LW, Zhang Y, Bharadwaj U, Zhang R, Li F, Fisher WE, Brunicardi FC, Chen C, Yao Q, Min L. IL-6 stimulates Th2 type cytokine secretion and upregulates VEGF and NRP-1 expression in pancreatic cancer cells. Cancer Biol Ther. 2007 Jul; 6(7):1096-100. PMID: 17568185.
      Citations: 46     Fields:    Translation:HumansCells
    98. Wang X, Mu H, Chai H, Liao D, Yao Q, Chen C. Human immunodeficiency virus protease inhibitor ritonavir inhibits cholesterol efflux from human macrophage-derived foam cells. Am J Pathol. 2007 Jul; 171(1):304-14. PMID: 17591975; PMCID: PMC1941585.
      Citations: 23     Fields:    Translation:HumansCells
    99. Bechara C, Chai H, Lin PH, Yao Q, Chen C. Growth related oncogene-alpha (GRO-alpha): roles in atherosclerosis, angiogenesis and other inflammatory conditions. Med Sci Monit. 2007 Jun; 13(6):RA87-90. PMID: 17534244.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    100. Bharadwaj U, Li M, Zhang R, Chen C, Yao Q. Elevated interleukin-6 and G-CSF in human pancreatic cancer cell conditioned medium suppress dendritic cell differentiation and activation. Cancer Res. 2007 Jun 01; 67(11):5479-88. PMID: 17545630.
      Citations: 65     Fields:    Translation:HumansCells
    101. Mu H, Ohashi R, Yan S, Chai H, Yang H, Lin P, Yao Q, Chen C. Adipokine resistin promotes in vitro angiogenesis of human endothelial cells. Cardiovasc Res. 2006 Apr 01; 70(1):146-57. PMID: 16515776.
      Citations: 57     Fields:    Translation:HumansCells
    102. Mohiuddin I, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Nitrotyrosine and chlorotyrosine: clinical significance and biological functions in the vascular system. J Surg Res. 2006 Jun 15; 133(2):143-9. PMID: 16360172.
      Citations: 38     Fields:    Translation:HumansAnimals
    103. Ohashi R, Yan S, Mu H, Chai H, Yao Q, Lin PH, Chen C. Effects of homocysteine and ginsenoside Rb1 on endothelial proliferation and superoxide anion production. J Surg Res. 2006 Jun 15; 133(2):89-94. PMID: 16271366.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    104. Li M, Wang H, Li F, Fisher WE, Chen C, Yao Q. Effect of cyclophilin A on gene expression in human pancreatic cancer cells. Am J Surg. 2005 Nov; 190(5):739-45. PMID: 16226951.
      Citations: 8     Fields:    Translation:HumansCells
    105. Yan S, Chai H, Wang H, Yang H, Nan B, Yao Q, Chen C. Effects of lysophosphatidylcholine on monolayer cell permeability of human coronary artery endothelial cells. Surgery. 2005 Sep; 138(3):464-73. PMID: 16213900.
      Citations: 12     Fields:    Translation:HumansCells
    106. Chai H, Yang H, Yan S, Li M, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of 5 HIV protease inhibitors on vasomotor function and superoxide anion production in porcine coronary arteries. J Acquir Immune Defic Syndr. 2005 Sep 01; 40(1):12-9. PMID: 16123675.
      Citations: 24     Fields:    Translation:AnimalsCells
    107. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Review: application of stem cells for vascular tissue engineering. Tissue Eng. 2005 Sep-Oct; 11(9-10):1535-52. PMID: 16259608.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    108. Nan B, Yang H, Yan S, Lin PH, Lumsden AB, Yao Q, Chen C. C-reactive protein decreases expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Surgery. 2005 Aug; 138(2):212-22. PMID: 16153429.
      Citations: 11     Fields:    Translation:HumansCells
    109. Safaya R, Chai H, Kougias P, Lin P, Lumsden A, Yao Q, Chen C. Effect of lysophosphatidylcholine on vasomotor functions of porcine coronary arteries. J Surg Res. 2005 Jun 15; 126(2):182-8. PMID: 15919417.
      Citations: 9     Fields:    Translation:Animals
    110. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Effects of adipocyte-derived cytokines on endothelial functions: implication of vascular disease. J Surg Res. 2005 Jun 01; 126(1):121-9. PMID: 15916985.
      Citations: 35     Fields:    Translation:HumansAnimals
    111. Fu W, Chai H, Yao Q, Chen C. Effects of HIV protease inhibitor ritonavir on vasomotor function and endothelial nitric oxide synthase expression. J Acquir Immune Defic Syndr. 2005 Jun 01; 39(2):152-8. PMID: 15905730.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    112. Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Curcumin blocks HIV protease inhibitor ritonavir-induced vascular dysfunction in porcine coronary arteries. J Am Coll Surg. 2005 Jun; 200(6):820-30. PMID: 15922191.
      Citations: 10     Fields:    Translation:Animals
    113. Riha GM, Lin PH, Lumsden AB, Yao Q, Chen C. Roles of hemodynamic forces in vascular cell differentiation. Ann Biomed Eng. 2005 Jun; 33(6):772-9. PMID: 16078617.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    114. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Ginsenoside Rb1 blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2005 May; 41(5):861-8. PMID: 15886672.
      Citations: 33     Fields:    Translation:AnimalsCells
    115. Lin PH, Bush RL, Nguyen L, Guerrero MA, Chen C, Lumsden AB. Anastomotic strategies to improve hemodialysis access patency--a review. Vasc Endovascular Surg. 2005 Mar-Apr; 39(2):135-42. PMID: 15806274.
      Citations: 4     Fields:    Translation:Humans
    116. Li M, Fisher WE, Kim HJ, Wang X, Brunicardi CF, Chen C, Yao Q. Somatostatin, somatostatin receptors, and pancreatic cancer. World J Surg. 2005 Mar; 29(3):293-6. PMID: 15706439.
      Citations: 6     Fields:    Translation:HumansAnimals
    117. Rodriguez JA, Li M, Yao Q, Chen C, Fisher WE. Gene overexpression in pancreatic adenocarcinoma: diagnostic and therapeutic implications. World J Surg. 2005 Mar; 29(3):297-305. PMID: 15696394.
      Citations: 12     Fields:    Translation:Humans
    118. Wang XP, Yazawa K, Templeton NS, Yang J, Liu S, Li Z, Li M, Yao Q, Chen C, Brunicardi FC. Intravenous delivery of liposome-mediated nonviral DNA is less toxic than intraperitoneal delivery in mice. World J Surg. 2005 Mar; 29(3):339-43. PMID: 15706434.
      Citations: 3     Fields:    Translation:Animals
    119. Chen C, Li M, Chai H, Yang H, Fisher WE, Yao Q. Roles of neuropilins in neuronal development, angiogenesis, and cancers. World J Surg. 2005 Mar; 29(3):271-5. PMID: 15696396.
      Citations: 18     Fields:    Translation:HumansAnimalsCells
    120. Chen C, Li M, Yang H, Chai H, Fisher W, Yao Q. Roles of thymosins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):264-70. PMID: 15706436.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    121. Cox MW, Fu W, Chai H, Paladugu R, Lin PH, Lumsden AB, Yao Q, Chen C. Effects of progesterone and estrogen on endothelial dysfunction in porcine coronary arteries. J Surg Res. 2005 Mar; 124(1):104-11. PMID: 15734487.
      Citations: 13     Fields:    Translation:Animals
    122. Doan LX, Li M, Chen C, Yao Q. Virus-like particles as HIV-1 vaccines. Rev Med Virol. 2005 Mar-Apr; 15(2):75-88. PMID: 15484204.
      Citations: 34     Fields:    Translation:HumansAnimalsCells
    123. Yao Q, Li M, Yang H, Chai H, Fisher W, Chen C. Roles of cyclophilins in cancers and other organ systems. World J Surg. 2005 Mar; 29(3):276-80. PMID: 15706440.
      Citations: 32     Fields:    Translation:HumansCells
    124. Yang H, Li M, Chai H, Yan S, Lin P, Lumsden AB, Yao Q, Chen C. Effects of cyclophilin A on cell proliferation and gene expressions in human vascular smooth muscle cells and endothelial cells. J Surg Res. 2005 Feb; 123(2):312-9. PMID: 15680395.
      Citations: 13     Fields:    Translation:HumansCells
    125. Yan S, Li M, Chai H, Yang H, Lin PH, Yao Q, Chen C. TNF-alpha decreases expression of somatostatin, somatostatin receptors, and cortistatin in human coronary endothelial cells. J Surg Res. 2005 Feb; 123(2):294-301. PMID: 15680393.
      Citations: 10     Fields:    Translation:HumansCells
    126. Mu H, Ohashi R, Lin P, Yao Q, Chen C. Cellular and molecular mechanisms of coronary vessel development. Vasc Med. 2005 Feb; 10(1):37-44. PMID: 15920999.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    127. Kougias P, Chai H, Lin PH, Yao Q, Lumsden AB, Chen C. Defensins and cathelicidins: neutrophil peptides with roles in inflammation, hyperlipidemia and atherosclerosis. J Cell Mol Med. 2005 Jan-Mar; 9(1):3-10. PMID: 15784160; PMCID: PMC6741354.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    128. Lin PH, Bush RL, Yao Q, Lam R, Paladugu R, Zhou W, Chen C, Lumsden AB. Abdominal aortic surgery in patients with human immunodeficiency virus infection. Am J Surg. 2004 Dec; 188(6):690-7. PMID: 15619485.
      Citations: 8     Fields:    Translation:Humans
    129. Ramaswami G, Chai H, Yao Q, Lin PH, Lumsden AB, Chen C. Curcumin blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2004 Dec; 40(6):1216-22. PMID: 15622377.
      Citations: 18     Fields:    Translation:Animals
    130. Yang H, Li M, Chai H, Yan S, Zhang R, Yao Q, Chen C. Expression and regulation of neuropilins and VEGF receptors by TNF-alpha in human endothelial cells. J Surg Res. 2004 Dec; 122(2):249-55. PMID: 15555625.
      Citations: 6     Fields:    Translation:HumansCells
    131. Zhang R, Li M, Chen C, Yao Q. SHIV virus-like particles bind and activate human dendritic cells. Vaccine. 2004 Nov 25; 23(2):139-47. PMID: 15531030.
      Citations: 13     Fields:    Translation:HumansCells
    132. Li M, Yang H, Chai H, Fisher WE, Wang X, Brunicardi FC, Yao Q, Chen C. Pancreatic carcinoma cells express neuropilins and vascular endothelial growth factor, but not vascular endothelial growth factor receptors. Cancer. 2004 Nov 15; 101(10):2341-50. PMID: 15476280.
      Citations: 25     Fields:    Translation:HumansCells
    133. Nan B, Lin P, Lumsden AB, Yao Q, Chen C. Effects of TNF-alpha and curcumin on the expression of thrombomodulin and endothelial protein C receptor in human endothelial cells. Thromb Res. 2005; 115(5):417-26. PMID: 15733976.
      Citations: 24     Fields:    Translation:HumansCells
    134. Conklin BS, Fu W, Lin PH, Lumsden AB, Yao Q, Chen C. HIV protease inhibitor ritonavir decreases endothelium-dependent vasorelaxation and increases superoxide in porcine arteries. Cardiovasc Res. 2004 Jul 01; 63(1):168-75. PMID: 15194474.
      Citations: 22     Fields:    Translation:AnimalsCells
    135. Ohashi R, Mu H, Yao Q, Chen C. Cellular and molecular mechanisms of atherosclerosis with mouse models. Trends Cardiovasc Med. 2004 Jul; 14(5):187-90. PMID: 15261890.
      Citations: 11     Fields:    Translation:Animals
    136. Li M, Li W, Kim HJ, Yao Q, Chen C, Fisher WE. Characterization of somatostatin receptor expression in human pancreatic cancer using real-time RT-PCR. J Surg Res. 2004 Jun 15; 119(2):130-7. PMID: 15145694.
      Citations: 16     Fields:    Translation:HumansCells
    137. Wu H, Yao Q, Lumsden A, Chen C. Characterization of two populations of human coronary artery endothelial cells(1). J Surg Res. 2004 May 01; 118(1):38-44. PMID: 15093715.
      Citations: 4     Fields:    Translation:HumansCells
    138. Spencer TA, Chai H, Fu W, Ramaswami G, Cox MW, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Estrogen blocks homocysteine-induced endothelial dysfunction in porcine coronary arteries(1,2). J Surg Res. 2004 May 01; 118(1):83-90. PMID: 15093721.
      Citations: 6     Fields:    Translation:Animals
    139. Lin PH, Bush RL, Chen C, Lumsden AB. What is new in the preoperative evaluation of arteriovenous access operation? Semin Vasc Surg. 2004 Mar; 17(1):57-63. PMID: 15011181.
      Citations:    Fields:    Translation:Humans
    140. Zhou W, Chai H, Lin PH, Lumsden AB, Yao Q, Chen C. Clinical use and molecular mechanisms of action of extract of Ginkgo biloba leaves in cardiovascular diseases. Cardiovasc Drug Rev. 2004; 22(4):309-19. PMID: 15592576.
      Citations: 20     Fields:    Translation:HumansAnimals
    141. Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Red wine prevents homocysteine-induced endothelial dysfunction in porcine coronary arteries. J Surg Res. 2003 Nov; 115(1):82-91. PMID: 14572777.
      Citations: 6     Fields:    Translation:Animals
    142. Paladugu R, Fu W, Conklin BS, Lin PH, Lumsden AB, Yao Q, Chen C. Hiv Tat protein causes endothelial dysfunction in porcine coronary arteries. J Vasc Surg. 2003 Sep; 38(3):549-55; discussion 555-6. PMID: 12947275.
      Citations: 33     Fields:    Translation:AnimalsCells
    143. Lin PH, Bush RL, Milas M, Terramani TT, Dodson TF, Chen C, Chaikof EL, Lumsden AB. Impact of an endovascular program on the operative experience of abdominal aortic aneurysm in vascular fellowship and general surgery residency. Am J Surg. 2003 Aug; 186(2):189-93. PMID: 12885616.
      Citations: 2     Fields:    Translation:Humans
    144. Bush RL, Lin PH, Reddy PP, Chen C, Weiss VJ, Guinn G, Lumsden AB. Epidural analgesia in patients with chronic obstructive pulmonary disease undergoing transperitoneal abdominal aortic aneurysmorraphy--a multi-institutional analysis. Cardiovasc Surg. 2003 Jun; 11(3):179-84. PMID: 12704325.
      Citations: 1     Fields:    Translation:Humans
    145. Lin PH, Chronos NA, Marijianowski MM, Chen C, Bush RL, Conklin B, Lumsden AB, Hanson SR. Heparin-coated balloon-expandable stent reduces intimal hyperplasia in the iliac artery in baboons. J Vasc Interv Radiol. 2003 May; 14(5):603-11. PMID: 12761314.
      Citations: 2     Fields:    Translation:Animals
    146. Lin PH, Martin L, Matsuura JH, Wellons E, Bush RL, Terramani TT, Chen C, Lumsden AB. Intraaortic stabilization of the AneuRx stent-graft system: a useful adjunct to minimize device migration. Cardiovasc Intervent Radiol. 2003 Jan-Feb; 26(1):73-5. PMID: 12491021.
      Citations:    Fields:    Translation:Humans
    147. Lin PH, Kulbaski MJ, Terramani TT, Bush RL, Brinkman WT, Chen C, Conklin B, Lumsden AB. The regained referral ground and clinical practice of vena cava filter placement in vascular surgery. Am Surg. 2002 Oct; 68(10):865-70. PMID: 12412712.
      Citations:    Fields:    Translation:Humans
    148. Lin PH, Bush RL, Chaikof EL, Chen C, Conklin B, Terramani TT, Brinkman WT, Lumsden AB. A prospective evaluation of hypogastric artery embolization in endovascular aortoiliac aneurysm repair. J Vasc Surg. 2002 Sep; 36(3):500-6. PMID: 12218973.
      Citations: 23     Fields:    Translation:Humans
    149. Lin PH, Bush RL, Conklin BS, Chen C, Weiss VJ, Chaikof EL, Lumsden AB. Late complication of aortoiliac stent placement- atheroembolization of the lower extremities. J Surg Res. 2002 Apr; 103(2):153-9. PMID: 11922729.
      Citations: 3     Fields:    Translation:Humans
    150. Ren Z, Yao Q, Chen C. HIV-1 envelope glycoprotein 120 increases intercellular adhesion molecule-1 expression by human endothelial cells. Lab Invest. 2002 Mar; 82(3):245-55. PMID: 11896203.
      Citations: 32     Fields:    Translation:HumansCells
    151. Conklin BS, Zhong DS, Zhao W, Lin PH, Chen C. Shear stress regulates occludin and VEGF expression in porcine arterial endothelial cells. J Surg Res. 2002 Jan; 102(1):13-21. PMID: 11792146.
      Citations: 27     Fields:    Translation:AnimalsCells
    152. Chen C, Conklin BS, Ren Z, Zhong DS. Homocysteine decreases endothelium-dependent vasorelaxation in porcine arteries. J Surg Res. 2002 Jan; 102(1):22-30. PMID: 11792147.
      Citations: 16     Fields:    Translation:Animals
    153. Chen C, Surowiec SM, Morsy AH, Ma M. Intraperitoneal infusion of homocysteine increases intimal hyperplasia in balloon-injured rat carotid arteries. Atherosclerosis. 2002 Jan; 160(1):103-14. PMID: 11755927.
      Citations: 2     Fields:    Translation:Animals
    154. Lin PH, Dodson TF, Bush RL, Weiss VJ, Conklin BS, Chen C, Chaikof EL, Lumsden AB. Surgical intervention for complications caused by femoral artery catheterization in pediatric patients. J Vasc Surg. 2001 Dec; 34(6):1071-8. PMID: 11743563.
      Citations: 27     Fields:    Translation:Humans
    155. Yao Q, Compans RW, Chen C. HIV envelope proteins differentially utilize CXCR4 and CCR5 coreceptors for induction of apoptosis. Virology. 2001 Jun 20; 285(1):128-37. PMID: 11414813.
      Citations: 12     Fields:    Translation:HumansCells
    156. Lin PH, Chen C, Surowiec SM, Conklin B, Bush RL, Lumsden AB. Evaluation of thrombolysis in a porcine model of chronic deep venous thrombosis: an endovascular model. J Vasc Surg. 2001 Mar; 33(3):621-7. PMID: 11241136.
      Citations: 8     Fields:    Translation:Animals
    157. Lin PH, Surowiec SM, Conklin B, Bush RL, Chen C, Chaikof EL, Lumsden AB. An endovascular model of carotid stenosis for the evaluation of thrombolysis and angioplasty. J Endovasc Ther. 2000 Dec; 7(6):486-93. PMID: 11194820.
      Citations: 2     Fields:    Translation:Animals
    158. Lin PH, Surowiec SM, Conklin B, Chen C, Bush R, Weiss VJ, Lumsden AB. Evaluation of thrombolysis and angioplasty in a porcine iliac artery thrombosis model: application of endovascular stent-graft-induced thrombosis. J Vasc Interv Radiol. 2000 Jun; 11(6):785-91. PMID: 10877428.
      Citations:    Fields:    Translation:Animals
    159. Yao Q, Kuhlmann FM, Eller R, Compans RW, Chen C. Production and characterization of simian--human immunodeficiency virus-like particles. AIDS Res Hum Retroviruses. 2000 Feb 10; 16(3):227-36. PMID: 10710211.
      Citations: 22     Fields:    Translation:HumansAnimalsCells
    160. Chen C, Halkos ME, Surowiec SM, Conklin BS, Lin PH, Lumsden AB. Effects of homocysteine on smooth muscle cell proliferation in both cell culture and artery perfusion culture models. J Surg Res. 2000 Jan; 88(1):26-33. PMID: 10644463.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    161. Chen C, Mattar SG, Lumsden AB. Oral administration of L-arginine reduces intimal hyperplasia in balloon-injured rat carotid arteries. J Surg Res. 1999 Mar; 82(1):17-23. PMID: 10068520.
      Citations: 5     Fields:    Translation:Animals
    162. Chen C, Ofenloch JC, Yianni YP, Hanson SR, Lumsden AB. Phosphorylcholine coating of ePTFE reduces platelet deposition and neointimal hyperplasia in arteriovenous grafts. J Surg Res. 1998 Jul 01; 77(2):119-25. PMID: 9733597.
      Citations: 8     Fields:    Translation:AnimalsCells
    163. Chen C, Li J, Micko CJ, Pierce GF, Cunningham MR, Lumsden AB. Cytotoxic effects of basic FGF and heparin binding EGF conjugated with cytotoxin saporin on vascular cell cultures. J Surg Res. 1998 Feb 15; 75(1):35-41. PMID: 9614854.
      Citations: 3     Fields:    Translation:HumansCells
    164. Morsy AH, Kulbaski M, Chen C, Isiklar H, Lumsden AB. Incidence and characteristics of patients with hand ischemia after a hemodialysis access procedure. J Surg Res. 1998 Jan; 74(1):8-10. PMID: 9536965.
      Citations: 23     Fields:    Translation:Humans
    165. Chen C, Li J, Mattar SG, Pierce GF, Aukerman L, Hanson SR, Lumsden AB. Boundary layer infusion of basic fibroblast growth factor accelerates intimal hyperplasia in endarterectomized canine artery. J Surg Res. 1997 May; 69(2):300-6. PMID: 9224397.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    166. Chen C, Hughes JD, Mattar SG, Ku DN, Lumsden AB. Time-course study of intimal hyperplasia in the endarterectomized canine artery. J Surg Res. 1997 Jan; 67(1):106-12. PMID: 9070191.
      Citations: 1     Fields:    Translation:AnimalsCells
    167. Ofenloch JC, Chen C, Hughes JD, Lumsden AB. Endoscopic venous valve transplantation with a valve-stent device. Ann Vasc Surg. 1997 Jan; 11(1):62-7. PMID: 9061141.
      Citations:    Fields:    Translation:Animals
    168. Chen C, Hanson SR, Keefer LK, Saavedra JE, Davies KM, Hutsell TC, Hughes JD, Ku DN, Lumsden AB. Boundary layer infusion of nitric oxide reduces early smooth muscle cell proliferation in the endarterectomized canine artery. J Surg Res. 1997 Jan; 67(1):26-32. PMID: 9070177.
      Citations: 8     Fields:    Translation:Animals
    169. Lumsden AB, Chen C, Coyle KA, Ofenloch JC, Wang JH, Yasuda HK, Hanson SR. Nonporous silicone polymer coating of expanded polytetrafluoroethylene grafts reduces graft neointimal hyperplasia in dog and baboon models. J Vasc Surg. 1996 Nov; 24(5):825-33. PMID: 8918330.
      Citations: 6     Fields:    Translation:Animals
    170. Hughes JD, Chen C, Mattar SG, Someren A, Noe B, Suwyn CR, Lumsden AB. Normothermic renal artery perfusion: a comparison of perfusates. Ann Vasc Surg. 1996 Mar; 10(2):123-30. PMID: 8733863.
      Citations: 1     Fields:    Translation:Animals
    171. Hughes JD, Mattar SG, Chen C, Someren A, Noe B, Suwyn CR, Lumsden AB. Renal artery perfusion modifies ischemia/reperfusion injury. J Surg Res. 1996 Feb 01; 60(2):321-6. PMID: 8598662.
      Citations:    Fields:    Translation:Animals
    172. Chen C, Ku DN, Kikeri D, Lumsden AB. Tenascin: a potential role in human arteriovenous PTFE graft failure. J Surg Res. 1996 Feb 01; 60(2):409-16. PMID: 8598678.
      Citations: 3     Fields:    Translation:HumansCells
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