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DAISUKE NAKADA

TitleProfessor
InstitutionBaylor College of Medicine
DepartmentDepartment of Molecular & Human Genetics
AddressOne Baylor Plaza
Houston, TX 77030
Email
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    Collapse Biography 
    Collapse education and training
    Nagoya University , JapanBS2001Biological Science
    Nagoya University , JapanPhD2005Biological Science
    University of Michigan, Ann Arbor, MI2011Stem Cell Biology
    Collapse awards and honors
    2011 - 2015Scholar in Cancer Research, CPRIT
    2019 - 2024Scholar, Leukemia and Lymphoma Society

    Collapse Overview 
    Collapse overview
    Our laboratory studies the metabolic and transcriptional mechanisms that regulate hematopoietic stem cell (HSC) maintenance and their transformation. We identified fundamental properties that enable metabolic (Nature. 2010) and endocrine regulation of HSCs (Nature. 2014, eLife. 2018). We also study how the niche influences HSC differentiation into adipocyte within the bone marrow (Stem Cell Reports. 2019) and epigenetic regulation of HSCs (Stem Cell Reports. 2021). We developed a CRISPR/Cas9-based method to edit the genome of both murine and human hematopoietic progenitor cells, paving the way to perform genetics-based discovery research using these cells (Cell Reports. 2016, Exp. Hematol. 2018, Blood. 2019). We also study how metabolic processes regulate stem cells, and discovered a metabolic pathway governed by AMPK that is particularly important for cancer stem cells but not normal HSCs, potentially providing an intriguing therapeutic target to kill tumor-initiating cells without harming normal HSCs (Cell Stem Cell. 2015, Blood. 2019, Sci Adv. 2021, Cell Stem Cell. 2022). By improving our understanding of how stem cells proliferate and differentiate, it may be possible to advance a number of clinical goals including improving bone marrow transplantation and treating genetic disorders of metabolism.
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    Collapse Research 
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    R01CA255813     (NAKADA, DAISUKE)Jul 1, 2021 - Jun 30, 2026
    NIH
    THE ROLE OF SELENOPROTEIN SYNTHESIS PATHWAY IN ACUTE MYELOID LEUKEMIA
    Role: Principal Investigator
    R01DK107413     (NAKADA, DAISUKE)Jan 1, 2016 - Dec 31, 2020
    NIH
    Mesenchymal Stromal Cells Regulate Hematopoietic Stem Cell Aging
    Role: Principal Investigator
    R01CA193235     (NAKADA, DAISUKE)Apr 1, 2015 - Jun 30, 2025
    NIH
    METABOLIC REGULATION IN LEUKEMIA-INITIATING CELLS
    Role: Principal Investigator

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    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Tseng YJ, Kageyama Y, Murdaugh RL, Kitano A, Kim JH, Hoegenauer KA, Tiessen J, Smith MH, Uryu H, Takahashi K, Martin JF, Samee MAH, Nakada D. Increased iron uptake by splenic hematopoietic stem cells promotes TET2-dependent erythroid regeneration. Nat Commun. 2024 Jan 15; 15(1):538. PMID: 38225226; PMCID: PMC10789814.
      Citations:    Fields:    Translation:HumansCells
    2. Burgess RJ, Zhao Z, Nakada D, Morrison SJ. Bmi1 suppresses protein synthesis and promotes proteostasis in hematopoietic stem cells. Genes Dev. 2022 08 01; 36(15-16):887-900. PMID: 36167470; PMCID: PMC9575696.
      Citations: 4     Fields:    Translation:Cells
    3. Eagle K, Jiang Y, Shi X, Li M, Obholzer ND, Hu T, Perez MW, Kitano A, Yi JS, Lin CY, Nakada D, Koren JV. An oncogenic enhancer encodes selective selenium dependency in AML. Cell Stem Cell. 2022 Apr 07; 29(4):650. PMID: 35395189; PMCID: PMC9118464.
      Citations:    Fields:    
    4. Eagle K, Jiang Y, Shi X, Li M, Obholzer NP, Hu T, Perez MW, Kitano A, Yi JS, Lin CY, Nakada D, Koren JV. An oncogenic enhancer encodes selective selenium dependency in AML. Cell Stem Cell. 2022 03 03; 29(3):386-399.e7. PMID: 35108519; PMCID: PMC8903199.
      Citations:    Fields:    Translation:HumansAnimalsCells
    5. Wang Y, Huo T, Tseng YJ, Dang L, Yu Z, Yu W, Foulks Z, Murdaugh RL, Ludtke SJ, Nakada D, Wang Z. Using Cryo-ET to distinguish platelets during pre-acute myeloid leukemia from steady state hematopoiesis. Commun Biol. 2022 01 20; 5(1):72. PMID: 35058565; PMCID: PMC8776871.
      Citations:    Translation:AnimalsCells
    6. Shi X, Jiang Y, Kitano A, Hu T, Murdaugh RL, Li Y, Hoegenauer KA, Chen R, Takahashi K, Nakada D. Nuclear NAD+ homeostasis governed by NMNAT1 prevents apoptosis of acute myeloid leukemia stem cells. Sci Adv. 2021 07; 7(30). PMID: 34290089; PMCID: PMC8294764.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    7. Murdaugh RL, Hoegenauer KA, Kitano A, Holt MV, Hill MC, Shi X, Tiessen JF, Chapple R, Hu T, Tseng YJ, Lin A, Martin JF, Young NL, Nakada D. The histone H3.3 chaperone HIRA restrains erythroid-biased differentiation of adult hematopoietic stem cells. Stem Cell Reports. 2021 08 10; 16(8):2014-2028. PMID: 34242617; PMCID: PMC8365107.
      Citations: 1     Fields:    Translation:AnimalsCells
    8. Morita K, Wang F, Jahn K, Hu T, Tanaka T, Sasaki Y, Kuipers J, Loghavi S, Wang SA, Yan Y, Furudate K, Matthews J, Little L, Gumbs C, Zhang J, Song X, Thompson E, Patel KP, Bueso-Ramos CE, DiNardo CD, Ravandi F, Jabbour E, Andreeff M, Cortes J, Bhalla K, Garcia-Manero G, Kantarjian H, Konopleva M, Nakada D, Navin N, Beerenwinkel N, Futreal PA, Takahashi K. Author Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2021 May 10; 12(1):2823. PMID: 33972555; PMCID: PMC8110810.
      Citations: 1     Fields:    
    9. Takahashi M, Barile M, Chapple RH, Tseng YJ, Nakada D, Busch K, Fanti AK, S?w?n P, Bryder D, H?fer T, G?ttgens B. Reconciling Flux Experiments for Quantitative Modeling of Normal and Malignant Hematopoietic Stem/Progenitor Dynamics. Stem Cell Reports. 2021 04 13; 16(4):741-753. PMID: 33770496; PMCID: PMC8072066.
      Citations: 1     Fields:    Translation:AnimalsCells
    10. Morita K, Wang F, Jahn K, Hu T, Tanaka T, Sasaki Y, Kuipers J, Loghavi S, Wang SA, Yan Y, Furudate K, Matthews J, Little L, Gumbs C, Zhang J, Song X, Thompson E, Patel KP, Bueso-Ramos CE, DiNardo CD, Ravandi F, Jabbour E, Andreeff M, Cortes J, Bhalla K, Garcia-Manero G, Kantarjian H, Konopleva M, Nakada D, Navin N, Beerenwinkel N, Futreal PA, Takahashi K. Publisher Correction: Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2020 Nov 19; 11(1):5996. PMID: 33214561; PMCID: PMC7677309.
      Citations: 3     Fields:    
    11. Morita K, Wang F, Jahn K, Hu T, Tanaka T, Sasaki Y, Kuipers J, Loghavi S, Wang SA, Yan Y, Furudate K, Matthews J, Little L, Gumbs C, Zhang J, Song X, Thompson E, Patel KP, Bueso-Ramos CE, DiNardo CD, Ravandi F, Jabbour E, Andreeff M, Cortes J, Bhalla K, Garcia-Manero G, Kantarjian H, Konopleva M, Nakada D, Navin N, Beerenwinkel N, Futreal PA, Takahashi K. Clonal evolution of acute myeloid leukemia revealed by high-throughput single-cell genomics. Nat Commun. 2020 10 21; 11(1):5327. PMID: 33087716; PMCID: PMC7577981.
      Citations: 66     Fields:    Translation:HumansAnimals
    12. Xu L, Liu X, Peng F, Zhang W, Zheng L, Ding Y, Gu T, Lv K, Wang J, Ortinau L, Hu T, Shi X, Shi G, Shang G, Sun S, Iwawaki T, Ji Y, Li W, Rosen JM, Zhang XH, Park D, Adoro S, Catic A, Tong W, Qi L, Nakada D, Chen X. Protein quality control through endoplasmic reticulum-associated degradation maintains haematopoietic stem cell identity and niche interactions. Nat Cell Biol. 2020 10; 22(10):1162-1169. PMID: 32958856; PMCID: PMC7888538.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    13. Lee H, Zandkarimi F, Zhang Y, Meena JK, Kim J, Zhuang L, Tyagi S, Ma L, Westbrook TF, Steinberg GR, Nakada D, Stockwell BR, Gan B. Energy-stress-mediated AMPK activation inhibits ferroptosis. Nat Cell Biol. 2020 02; 22(2):225-234. PMID: 32029897; PMCID: PMC7008777.
      Citations: 130     Fields:    Translation:HumansAnimalsCells
    14. King KY, Huang Y, Nakada D, Goodell MA. Environmental influences on clonal hematopoiesis. Exp Hematol. 2020 03; 83:66-73. PMID: 31893524; PMCID: PMC7103536.
      Citations: 18     Fields:    Translation:HumansAnimalsCellsPHPublic Health
    15. Jiang Y, Hu T, Wang T, Shi X, Kitano A, Eagle K, Hoegenauer KA, Konopleva MY, Lin CY, Young NL, Nakada D. AMP-activated protein kinase links acetyl-CoA homeostasis to BRD4 recruitment in acute myeloid leukemia. Blood. 2019 12 12; 134(24):2183-2194. PMID: 31697807; PMCID: PMC6908829.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    16. Hu T, Morita K, Hill MC, Jiang Y, Kitano A, Saito Y, Wang F, Mao X, Hoegenauer KA, Morishita K, Martin JF, Futreal PA, Takahashi K, Nakada D. PRDM16s transforms megakaryocyte-erythroid progenitors into myeloid leukemia-initiating cells. Blood. 2019 08 15; 134(7):614-625. PMID: 31270104; PMCID: PMC6695560.
      Citations: 11     Fields:    Translation:HumansAnimalsCells
    17. Hu T, Kitano A, Luu V, Dawson B, Hoegenauer KA, Lee BH, Nakada D. Bmi1 Suppresses Adipogenesis in the Hematopoietic Stem Cell Niche. Stem Cell Reports. 2019 09 10; 13(3):545-558. PMID: 31257132; PMCID: PMC6739622.
      Citations: 9     Fields:    Translation:AnimalsCells
    18. Nakada D. Venetolax with Azacitidine Drains Fuel from AML Stem Cells. Cell Stem Cell. 2019 01 03; 24(1):7-8. PMID: 30609400.
      Citations: 3     Fields:    Translation:HumansCells
    19. Chapple RH, Tseng YJ, Hu T, Kitano A, Takeichi M, Hoegenauer KA, Nakada D. Lineage tracing of murine adult hematopoietic stem cells reveals active contribution to steady-state hematopoiesis. Blood Adv. 2018 06 12; 2(11):1220-1228. PMID: 29848758; PMCID: PMC5998934.
      Citations: 30     Fields:    Translation:AnimalsCells
    20. Shi X, Kitano A, Jiang Y, Luu V, Hoegenauer KA, Nakada D. Clonal expansion and myeloid leukemia progression modeled by multiplex gene editing of murine hematopoietic progenitor cells. Exp Hematol. 2018 08; 64:33-44.e5. PMID: 29751067; PMCID: PMC6088788.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    21. Brunetti L, Gundry MC, Kitano A, Nakada D, Goodell MA. Highly Efficient Gene Disruption of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. J Vis Exp. 2018 04 10; (134). PMID: 29708546; PMCID: PMC5933422.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    22. Chapple RH, Hu T, Tseng YJ, Liu L, Kitano A, Luu V, Hoegenauer KA, Iwawaki T, Li Q, Nakada D. ERa promotes murine hematopoietic regeneration through the Ire1a-mediated unfolded protein response. Elife. 2018 02 16; 7. PMID: 29451493; PMCID: PMC5829925.
      Citations: 20     Fields:    Translation:AnimalsCells
    23. Nakada D. ENLightening YEATS in antagonizing polycomb repression. Blood. 2018 02 08; 131(6):591. PMID: 29438969; PMCID: PMC5805493.
      Citations:    Fields:    Translation:Animals
    24. Hu T, Murdaugh R, Nakada D. Transcriptional and Microenvironmental Regulation of Lineage Ambiguity in Leukemia. Front Oncol. 2017; 7:268. PMID: 29164065; PMCID: PMC5681738.
      Citations: 9     
    25. Gundry MC, Brunetti L, Lin A, Mayle AE, Kitano A, Hsu JI, Hoegenauer KA, Rooney CM, Goodell MA, Nakada D, Wagner D. Highly Efficient Genome Editing of Murine and Human Hematopoietic Progenitor Cells by CRISPR/Cas9. Cell Rep. 2016 10 25; 17(5):1453-1461. PMID: 27783956; PMCID: PMC5087995.
      Citations: 114     Fields:    Translation:HumansAnimalsCells
    26. Jiang Y, Nakada D. Cell intrinsic and extrinsic regulation of leukemia cell metabolism. Int J Hematol. 2016 Jun; 103(6):607-16. PMID: 26897135; PMCID: PMC5949883.
      Citations: 14     Fields:    Translation:Humans
    27. Saito Y, Chapple RH, Lin A, Kitano A, Nakada D. AMPK Protects Leukemia-Initiating Cells in Myeloid Leukemias from Metabolic Stress in the Bone Marrow. Cell Stem Cell. 2015 Nov 05; 17(5):585-96. PMID: 26440282; PMCID: PMC4597792.
      Citations: 104     Fields:    Translation:AnimalsCells
    28. Bednar F, Schofield HK, Collins MA, Yan W, Zhang Y, Shyam N, Eberle JA, Almada LL, Olive KP, Bardeesy N, Fernandez-Zapico ME, Nakada D, Simeone DM, Morrison SJ, Pasca di Magliano M. Bmi1 is required for the initiation of pancreatic cancer through an Ink4a-independent mechanism. Carcinogenesis. 2015 Jul; 36(7):730-8. PMID: 25939753; PMCID: PMC4566095.
      Citations: 14     Fields:    Translation:Animals
    29. Mich JK, Signer RA, Nakada D, Burgess RJ, Vue TY, Johnson JE, Morrison SJ, Pineda A. Prospective identification of functionally distinct stem cells and neurosphere-initiating cells in adult mouse forebrain. Elife. 2014 May 07; 3:e02669. PMID: 24843006; PMCID: PMC4038845.
      Citations: 66     Fields:    Translation:AnimalsCells
    30. Nakada D, Oguro H, Levi BP, Ryan N, Kitano A, Saitoh Y, Takeichi M, Wendt GR, Morrison SJ. Oestrogen increases haematopoietic stem-cell self-renewal in females and during pregnancy. Nature. 2014 Jan 23; 505(7484):555-8. PMID: 24451543; PMCID: PMC4015622.
      Citations: 151     Fields:    Translation:AnimalsCells
    31. Saito Y, Nakada D. The role of the Lkb1/AMPK pathway in hematopoietic stem cells and Leukemia. Crit Rev Oncog. 2014; 19(5):383-97. PMID: 25404152.
      Citations: 6     Fields:    Translation:HumansCells
    32. Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K. Inhibition of AMPK catabolic action by GSK3. Mol Cell. 2013 May 09; 50(3):407-19. PMID: 23623684; PMCID: PMC3654099.
      Citations: 85     Fields:    Translation:HumansCells
    33. Magee JA, Ikenoue T, Nakada D, Lee JY, Guan KL, Morrison SJ. Temporal changes in PTEN and mTORC2 regulation of hematopoietic stem cell self-renewal and leukemia suppression. Cell Stem Cell. 2012 Sep 07; 11(3):415-28. PMID: 22958933; PMCID: PMC3447536.
      Citations: 108     Fields:    Translation:HumansAnimalsCells
    34. Yamada T, Park CS, Burns A, Nakada D, Lacorazza HD. The cytosolic protein G0S2 maintains quiescence in hematopoietic stem cells. PLoS One. 2012; 7(5):e38280. PMID: 22693613; PMCID: PMC3365016.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    35. Nakada D, Levi BP, Morrison SJ. Integrating physiological regulation with stem cell and tissue homeostasis. Neuron. 2011 May 26; 70(4):703-18. PMID: 21609826; PMCID: PMC4521627.
      Citations: 43     Fields:    Translation:HumansAnimalsCells
    36. Nakada D, Saunders TL, Morrison SJ. Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature. 2010 Dec 02; 468(7324):653-8. PMID: 21124450; PMCID: PMC3059717.
      Citations: 264     Fields:    Translation:AnimalsCells
    37. Lee JY, Nakada D, Yilmaz OH, Tothova Z, Joseph NM, Lim MS, Gilliland DG, Morrison SJ. mTOR activation induces tumor suppressors that inhibit leukemogenesis and deplete hematopoietic stem cells after Pten deletion. Cell Stem Cell. 2010 Nov 05; 7(5):593-605. PMID: 21040901; PMCID: PMC2995996.
      Citations: 109     Fields:    Translation:AnimalsCells
    38. He S, Nakada D, Morrison SJ. Mechanisms of stem cell self-renewal. Annu Rev Cell Dev Biol. 2009; 25:377-406. PMID: 19575646.
      Citations: 228     Fields:    Translation:HumansAnimalsCells
    39. Nakada D, Hirano Y, Tanaka Y, Sugimoto K. Role of the C terminus of Mec1 checkpoint kinase in its localization to sites of DNA damage. Mol Biol Cell. 2005 Nov; 16(11):5227-35. PMID: 16148046; PMCID: PMC1266421.
      Citations: 30     Fields:    Translation:AnimalsCells
    40. Nakada D, Hirano Y, Sugimoto K. Requirement of the Mre11 complex and exonuclease 1 for activation of the Mec1 signaling pathway. Mol Cell Biol. 2004 Nov; 24(22):10016-25. PMID: 15509802; PMCID: PMC525484.
      Citations: 56     Fields:    Translation:AnimalsCells
    41. Naiki T, Wakayama T, Nakada D, Matsumoto K, Sugimoto K. Association of Rad9 with double-strand breaks through a Mec1-dependent mechanism. Mol Cell Biol. 2004 Apr; 24(8):3277-85. PMID: 15060150; PMCID: PMC381673.
      Citations: 28     Fields:    Translation:AnimalsCells
    42. Nakada D, Matsumoto K, Sugimoto K. ATM-related Tel1 associates with double-strand breaks through an Xrs2-dependent mechanism. Genes Dev. 2003 Aug 15; 17(16):1957-62. PMID: 12923051; PMCID: PMC196250.
      Citations: 156     Fields:    Translation:AnimalsCells
    43. Nakada D, Shimomura T, Matsumoto K, Sugimoto K. The ATM-related Tel1 protein of Saccharomyces cerevisiae controls a checkpoint response following phleomycin treatment. Nucleic Acids Res. 2003 Mar 15; 31(6):1715-24. PMID: 12626713; PMCID: PMC152856.
      Citations: 32     Fields:    Translation:AnimalsCells
    44. Shiomi Y, Shinozaki A, Nakada D, Sugimoto K, Usukura J, Obuse C, Tsurimoto T. Clamp and clamp loader structures of the human checkpoint protein complexes, Rad9-1-1 and Rad17-RFC. Genes Cells. 2002 Aug; 7(8):861-8. PMID: 12167163.
      Citations: 31     Fields:    Translation:HumansCells
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