Header Logo

MOTONARI UESUGI

TitleAdjunct Associate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Biochemistry and Molecular Pharmacology
AddressOne Baylor Plaza, N411
Houston, TX 77030
vCardDownload vCard

    Collapse Research 
    Collapse research activities and funding
    R01CA109277     (UESUGI, MOTONARI)Jun 20, 2005 - May 31, 2008
    NIH
    Small-molecule analysis of signaling pathways
    Role: Principal Investigator
    R01GM071800     (UESUGI, MOTONARI)Aug 1, 2004 - Jul 31, 2009
    NIH
    Synthetic modulators of transcription
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
    Newest   |   Oldest   |   Most Cited   |   Most Discussed   |   Timeline   |   Field Summary   |   Plain Text
    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Ochiai T, Inukai T, Akiyama M, Furui K, Ohue M, Matsumori N, Inuki S, Uesugi M, Sunazuka T, Kikuchi K, Kakeya H, Sakakibara Y. Variational autoencoder-based chemical latent space for large molecular structures with 3D complexity. Commun Chem. 2023 Nov 16; 6(1):249. PMID: 37973971; PMCID: PMC10654724.
      Citations:    
    2. Jiang L, Liu S, Jia X, Gong Q, Wen X, Lu W, Yang J, Wu X, Wang X, Suo Y, Li Y, Uesugi M, Qu ZB, Tan M, Lu X, Zhou L. ABPP-CoDEL: Activity-Based Proteome Profiling-Guided Discovery of Tyrosine-Targeting Covalent Inhibitors from DNA-Encoded Libraries. J Am Chem Soc. 2023 11 22; 145(46):25283-25292. PMID: 37857329.
      Citations:    Fields:    
    3. Perron A, Mandal S, Chuba TN, Mao D, Singh VP, Noda N, Tan R, Vu HT, Abo M, Uesugi M. Small-Molecule Drug Repurposing for Counteracting Phototoxic A2E Aggregation. ACS Chem Biol. 2023 10 20; 18(10):2170-2175. PMID: 37708070.
      Citations:    Fields:    Translation:Humans
    4. Tanaka K, Suda A, Uesugi M, Futaki S, Imanishi M. Xanthine derivatives inhibit FTO in an L-ascorbic acid-dependent manner. Chem Commun (Camb). 2023 Sep 07; 59(72):10809-10812. PMID: 37599611.
      Citations: 1     Fields:    
    5. Zhuo SH, Noda N, Hioki K, Jin S, Hayashi T, Hiraga K, Momose H, Li WH, Zhao L, Mizukami T, Ishii KJ, Li YM, Uesugi M. Identification of a Self-Assembling Small-Molecule Cancer Vaccine Adjuvant with an Improved Toxicity Profile. J Med Chem. 2023 09 28; 66(18):13266-13279. PMID: 37676021.
      Citations:    Fields:    Translation:AnimalsCells
    6. Kawagoe F, Mototani S, Mendoza A, Takemoto Y, Uesugi M, Kittaka A. Structure-activity relationship studies on vitamin D-based selective SREBP/SCAP inhibitor KK-052. RSC Med Chem. 2023 Oct 18; 14(10):2030-2034. PMID: 37859714; PMCID: PMC10583829.
      Citations: 1     
    7. Cutrupi AN, Narayanan RK, Perez-Siles G, Grosz BR, Lai K, Boyling A, Ellis M, Lin RCY, Neumann B, Mao D, Uesugi M, Nicholson GA, Vucic S, Saporta MA, Kennerson ML. Novel gene-intergenic fusion involving ubiquitin E3 ligase UBE3C causes distal hereditary motor neuropathy. Brain. 2023 03 01; 146(3):880-897. PMID: 36380488; PMCID: PMC9976978.
      Citations:    Fields:    Translation:HumansAnimals
    8. Jin S, Zhuo SH, Takemoto Y, Li YM, Uesugi M. Self-assembling small-molecule adjuvants as antigen nano-carriers. Chem Commun (Camb). 2022 Nov 01; 58(87):12228-12231. PMID: 36254577.
      Citations:    Fields:    
    9. Toh K, Nishio K, Nakagawa R, Egoshi S, Abo M, Perron A, Sato SI, Okumura N, Koizumi N, Dodo K, Sodeoka M, Uesugi M. Chemoproteomic Identification of Blue-Light-Damaged Proteins. J Am Chem Soc. 2022 11 09; 144(44):20171-20176. PMID: 36306265.
      Citations:    Fields:    Translation:HumansAnimalsCells
    10. Nishio K, Toh K, Perron A, Goto M, Abo M, Shimakawa Y, Uesugi M. Magnetic Control of Cells by Chemical Fabrication of Melanin. J Am Chem Soc. 2022 09 21; 144(37):16720-16725. PMID: 36094431.
      Citations:    
    11. Katsuda Y, Sato SI, Inoue M, Tsugawa H, Kamura T, Kida T, Matsumoto R, Asamitsu S, Shioda N, Shiroto S, Oosawatsu Y, Yatsuzuka K, Kitamura Y, Hagihara M, Ihara T, Uesugi M. Small molecule-based detection of non-canonical RNA G-quadruplex structures that modulate protein translation. Nucleic Acids Res. 2022 08 12; 50(14):8143-8153. PMID: 35801908; PMCID: PMC9371906.
      Citations:    
    12. Hwang SY, Park S, Jo H, Hee Seo S, Jeon KH, Kim S, Jung AR, Song C, Ahn M, Yeon Kwak S, Lee HJ, Uesugi M, Na Y, Kwon Y. Interrupting specific hydrogen bonds between ELF3 and MED23 as an alternative drug resistance-free strategy for HER2-overexpressing cancers. J Adv Res. 2023 05; 47:173-187. PMID: 35963541; PMCID: PMC10173165.
      Citations:    
    13. Kawamura S, Matsushita Y, Kurosaki S, Tange M, Fujiwara N, Hayata Y, Hayakawa Y, Suzuki N, Hata M, Tsuboi M, Kishikawa T, Kinoshita H, Nakatsuka T, Sato M, Kudo Y, Hoshida Y, Umemura A, Eguchi A, Ikenoue T, Hirata Y, Uesugi M, Tateishi R, Tateishi K, Fujishiro M, Koike K, Nakagawa H. Inhibiting SCAP/SREBP exacerbates liver injury and carcinogenesis in murine nonalcoholic steatohepatitis. J Clin Invest. 2022 06 01; 132(11). PMID: 35380992; PMCID: PMC9151706.
      Citations: 1     Fields:    Translation:Animals
    14. Takada K, Hagiwara Y, Togashi M, Kittaka A, Kawagoe F, Uesugi M, Nishimoto-Kusunose S, Higashi T. 23,25-Dihydroxyvitamin D<sub>3</sub> is liberated as a major vitamin D<sub>3</sub> metabolite in human urine after treatment with ?-glucuronidase: Quantitative comparison with 24,25-dihydroxyvitamin D<sub>3</sub> by LC/MS/MS. J Steroid Biochem Mol Biol. 2022 Oct; 223:106133. PMID: 35654380.
      Citations:    Fields:    
    15. Ado G, Noda N, Vu HT, Perron A, Mahapatra AD, Arista KP, Yoshimura H, Packwood DM, Ishidate F, Sato SI, Ozawa T, Uesugi M. Discovery of a phase-separating small molecule that selectively sequesters tubulin in cells. Chem Sci. 2022 May 18; 13(19):5760-5766. PMID: 35694339; PMCID: PMC9116451.
      Citations:    
    16. Noda N, Jung Y, Ado G, Mizuhata Y, Higuchi M, Ogawa T, Ishidate F, Sato SI, Kurata H, Tokitoh N, Uesugi M. Glucose as a Protein-Condensing Cellular Solute. ACS Chem Biol. 2022 03 18; 17(3):567-575. PMID: 35188733.
      Citations:    Fields:    Translation:Cells
    17. Jung Y, Noda N, Takaya J, Abo M, Toh K, Tajiri K, Cui C, Zhou L, Sato SI, Uesugi M. Discovery of Non-Cysteine-Targeting Covalent Inhibitors by Activity-Based Proteomic Screening with a Cysteine-Reactive Probe. ACS Chem Biol. 2022 02 18; 17(2):340-347. PMID: 35076225.
      Citations:    Fields:    Translation:Cells
    18. Mendoza A, Takemoto Y, Cruzado KT, Masoud SS, Nagata A, Tantipanjaporn A, Okuda S, Kawagoe F, Sakamoto R, Odagi M, Mototani S, Togashi M, Kawatani M, Aono H, Osada H, Nakagawa H, Higashi T, Kittaka A, Nagasawa K, Uesugi M. Controlled lipid ?-oxidation and carnitine biosynthesis by a vitamin D metabolite. Cell Chem Biol. 2022 04 21; 29(4):660-669.e12. PMID: 34506728.
      Citations: 1     Fields:    Translation:AnimalsCells
    19. Takemoto Y, Kadota S, Minami I, Otsuka S, Okuda S, Abo M, Punzalan LL, Shen Y, Shiba Y, Uesugi M. Chemical Genetics Reveals a Role of Squalene Synthase in TGF? Signaling and Cardiomyogenesis. Angew Chem Int Ed Engl. 2021 09 27; 60(40):21824-21831. PMID: 34374184.
      Citations:    Fields:    Translation:HumansCells
    20. Nakashima M, Uesugi M. Asian Chemical Biology Initiative (ACBI): Bringing Together Chemical Biologists Within Asia. Chembiochem. 2021 09 14; 22(18):2738-2740. PMID: 34241966.
      Citations:    Fields:    Translation:Humans
    21. Long T, Liu L, Tao Y, Zhang W, Quan J, Zheng J, Uesugi M, Yao W, Tian H, Wang H, Hegemann JD. Light-Controlled Tyrosine Nitration of Proteins. Angew Chem Int Ed Engl. 2021 06 07; 60(24):13414-13422. PMID: 33847040.
      Citations: 2     Fields:    Translation:AnimalsCells
    22. Kaufmann M, Schlingmann KP, Berezin L, Molin A, Sheftel J, Vig M, Gallagher JC, Nagata A, Masoud SS, Sakamoto R, Nagasawa K, Uesugi M, Kottler ML, Konrad M, Jones G. Differential diagnosis of vitamin D-related hypercalcemia using serum vitamin D metabolite profiling. J Bone Miner Res. 2021 07; 36(7):1340-1350. PMID: 33856702.
      Citations: 8     Fields:    Translation:Humans
    23. Kawagoe F, Mendoza A, Hayata Y, Asano L, Kotake K, Mototani S, Kawamura S, Kurosaki S, Akagi Y, Takemoto Y, Nagasawa K, Nakagawa H, Uesugi M, Kittaka A. Discovery of a Vitamin D Receptor-Silent Vitamin D Derivative That Impairs Sterol Regulatory Element-Binding Protein In Vivo. J Med Chem. 2021 05 13; 64(9):5689-5709. PMID: 33899473.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    24. Li Q, Meissner TB, Wang F, Du Z, Ma S, Kshirsagar S, Tilburgs T, Buenrostro JD, Uesugi M, Strominger JL. ELF3 activated by a superenhancer and an autoregulatory feedback loop is required for high-level HLA-C expression on extravillous trophoblasts. Proc Natl Acad Sci U S A. 2021 03 02; 118(9). PMID: 33622787; PMCID: PMC7936349.
      Citations: 2     Fields:    Translation:HumansCells
    25. Hakariya H, Takashima I, Takemoto M, Noda N, Sato SI, Uesugi M. Non-genetic cell-surface modification with a self-assembling molecular glue. Chem Commun (Camb). 2021 Feb 15; 57(12):1470-1473. PMID: 33442714.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    26. Jin S, Vu HT, Hioki K, Noda N, Yoshida H, Shimane T, Ishizuka S, Takashima I, Mizuhata Y, Beverly Pe K, Ogawa T, Nishimura N, Packwood D, Tokitoh N, Kurata H, Yamasaki S, Ishii KJ, Uesugi M. Discovery of Self-Assembling Small Molecules as Vaccine Adjuvants. Angew Chem Int Ed Engl. 2021 01 11; 60(2):961-969. PMID: 32979004.
      Citations: 2     Fields:    Translation:AnimalsCells
    27. Ito D, Kawazoe Y, Sato A, Uesugi M, Hirata H. Identification of the hypertension drug niflumic acid as a glycine receptor inhibitor. Sci Rep. 2020 08 19; 10(1):13999. PMID: 32814817; PMCID: PMC7438329.
      Citations: 3     Fields:    Translation:AnimalsCells
    28. Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M. Correction to "Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators". ACS Chem Biol. 2020 08 21; 15(8):2311. PMID: 32697575.
      Citations:    Fields:    
    29. Punzalan LL, Jiang L, Mao D, Mahapatra AD, Sato S, Takemoto Y, Tsujimura M, Kusamori K, Nishikawa M, Zhou L, Uesugi M. Chemoproteomic Profiling of a Pharmacophore-Focused Chemical Library. Cell Chem Biol. 2020 06 18; 27(6):708-718.e10. PMID: 32402240.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    30. Zhang X, Jiang L, Huang K, Fang C, Li J, Yang J, Li H, Ruan X, Wang P, Mo M, Wu P, Xu Y, Peng C, Uesugi M, Ye D, Yu FX, Zhou L. Site-Selective Phosphoglycerate Mutase 1 Acetylation by a Small Molecule. ACS Chem Biol. 2020 03 20; 15(3):632-639. PMID: 32069008.
      Citations:    Fields:    Translation:HumansCells
    31. Perez-Siles G, Cutrupi A, Ellis M, Kuriakose J, La Fontaine S, Mao D, Uesugi M, Takata RI, Speck-Martins CE, Nicholson G, Kennerson ML. Modelling the pathogenesis of X-linked distal hereditary motor neuropathy using patient-derived iPSCs. Dis Model Mech. 2020 01 13; 13(2). PMID: 31969342; PMCID: PMC6994953.
      Citations: 1     Fields:    Translation:HumansCells
    32. Takemoto Y, Mao D, Punzalan LL, Sato SI, Uesugi M, G?tze S. Discovery of a Small-Molecule-Dependent Photolytic Peptide. J Am Chem Soc. 2020 01 22; 142(3):1142-1146. PMID: 31899620.
      Citations:    Fields:    Translation:HumansCells
    33. Nagata A, Akagi Y, Asano L, Kotake K, Kawagoe F, Mendoza A, Masoud SS, Usuda K, Yasui K, Takemoto Y, Kittaka A, Nagasawa K, Uesugi M. Synthetic Chemical Probes That Dissect Vitamin D Activities. ACS Chem Biol. 2019 12 20; 14(12):2851-2858. PMID: 31618573.
      Citations: 2     Fields:    Translation:Humans
    34. Kawagoe F, Mototani S, Yasuda K, Nagasawa K, Uesugi M, Sakaki T, Kittaka A. Introduction of fluorine atoms to vitamin D3 side-chain and synthesis of 24,24-difluoro-25-hydroxyvitamin D3. J Steroid Biochem Mol Biol. 2019 12; 195:105477. PMID: 31541729.
      Citations: 3     Fields:    
    35. Furuta T, Mizukami Y, Asano L, Kotake K, Ziegler S, Yoshida H, Watanabe M, Sato SI, Waldmann H, Nishikawa M, Uesugi M. Nutrient-Based Chemical Library as a Source of Energy Metabolism Modulators. ACS Chem Biol. 2019 09 20; 14(9):1860-1865. PMID: 31436407.
      Citations:    Fields:    Translation:HumansAnimalsCells
    36. Chen IS, Liu C, Tateyama M, Karbat I, Uesugi M, Reuveny E, Kubo Y. Non-sedating antihistamines block G-protein-gated inwardly rectifying K+ channels. Br J Pharmacol. 2019 09; 176(17):3161-3179. PMID: 31116876; PMCID: PMC6692640.
      Citations: 4     Fields:    Translation:AnimalsCells
    37. Kawagoe F, Yasuda K, Mototani S, Sugiyama T, Uesugi M, Sakaki T, Kittaka A. Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D3 Analogues. ACS Omega. 2019 Jun 30; 4(6):11332-11337. PMID: 31460236; PMCID: PMC6648426.
      Citations: 3     
    38. Nagata A, Akagi Y, Masoud SS, Yamanaka M, Kittaka A, Uesugi M, Odagi M, Nagasawa K. Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25. J Org Chem. 2019 06 21; 84(12):7630-7641. PMID: 30985122.
      Citations: 3     Fields:    Translation:Cells
    39. Takashima I, Kusamori K, Hakariya H, Takashima M, Vu TH, Mizukami Y, Noda N, Takayama Y, Katsuda Y, Sato SI, Takakura Y, Nishikawa M, Uesugi M. Multifunctionalization of Cells with a Self-Assembling Molecule to Enhance Cell Engraftment. ACS Chem Biol. 2019 04 19; 14(4):775-783. PMID: 30807095.
      Citations:    Fields:    Translation:AnimalsCells
    40. Nishikawa Y, Kodama Y, Shiokawa M, Matsumori T, Marui S, Kuriyama K, Kuwada T, Sogabe Y, Kakiuchi N, Tomono T, Mima A, Morita T, Ueda T, Tsuda M, Yamauchi Y, Sakuma Y, Ota Y, Maruno T, Uza N, Uesugi M, Kageyama R, Chiba T, Seno H. Hes1 plays an essential role in Kras-driven pancreatic tumorigenesis. Oncogene. 2019 05; 38(22):4283-4296. PMID: 30705405.
      Citations: 9     Fields:    Translation:AnimalsCells
    41. Kawagoe F, Sugiyama T, Yasuda K, Uesugi M, Sakaki T, Kittaka A. Concise synthesis of 23-hydroxylated vitamin D3 metabolites. J Steroid Biochem Mol Biol. 2019 02; 186:161-168. PMID: 30367940.
      Citations: 3     Fields:    
    42. Ohkanda J, Kusumoto A, Punzalan L, Masuda R, Wang C, Parvatkar P, Akase D, Aida M, Uesugi M, Higuchi Y, Kato N. Structural Effects of Fusicoccin upon Upregulation of 14-3-3-Phospholigand Interaction and Cytotoxic Activity. Chemistry. 2018 Oct 26; 24(60):16066-16071. PMID: 30238524.
      Citations: 3     Fields:    
    43. Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Shibata-Seki T, Yoshimoto K, Sakai R, Hakariya H, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Kamei KI, Chen Y. Fabrication of a Multiplexed Artificial Cellular MicroEnvironment Array. J Vis Exp. 2018 09 07; (139). PMID: 30247461; PMCID: PMC6235102.
      Citations: 1     Fields:    Translation:Humans
    44. Li Q, Yoshimura H, Komiya M, Tajiri K, Uesugi M, Hata Y, Ozawa T. A robust split-luciferase-based cell fusion screening for discovering myogenesis-promoting molecules. Analyst. 2018 Jul 09; 143(14):3472-3480. PMID: 29944152.
      Citations:    Fields:    Translation:AnimalsCells
    45. Yatsuzuka K, Sato SI, Pe KB, Katsuda Y, Takashima I, Watanabe M, Uesugi M. Live-cell imaging of multiple endogenous mRNAs permits the direct observation of RNA granule dynamics. Chem Commun (Camb). 2018 Jun 26; 54(52):7151-7154. PMID: 29882951.
      Citations: 4     Fields:    Translation:HumansCells
    46. Perron A, Nishikawa Y, Iwata J, Shimojo H, Takaya J, Kobayashi K, Imayoshi I, Mbenza NM, Takenoya M, Kageyama R, Kodama Y, Uesugi M. Small-molecule screening yields a compound that inhibits the cancer-associated transcription factor Hes1 via the PHB2 chaperone. J Biol Chem. 2018 05 25; 293(21):8285-8294. PMID: 29523683; PMCID: PMC5971435.
      Citations: 9     Fields:    Translation:HumansAnimalsCells
    47. Mao D, Chung XKW, Andoh-Noda T, Qin Y, Sato SI, Takemoto Y, Akamatsu W, Okano H, Uesugi M. Chemical decontamination of iPS cell-derived neural cell mixtures. Chem Commun (Camb). 2018 Feb 01; 54(11):1355-1358. PMID: 29350722.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    48. Sato SI, Yatsuzuka K, Katsuda Y, Uesugi M. Method for Imaging Live-Cell RNA Using an RNA Aptamer and a Fluorescent Probe. Methods Mol Biol. 2018; 1649:305-318. PMID: 29130206.
      Citations:    Fields:    Translation:HumansCells
    49. Kotaka M, Toyoda T, Yasuda K, Kitano Y, Okada C, Ohta A, Watanabe A, Uesugi M, Osafune K. Adrenergic receptor agonists induce the differentiation of pluripotent stem cell-derived hepatoblasts into hepatocyte-like cells. Sci Rep. 2017 12 01; 7(1):16734. PMID: 29196668; PMCID: PMC5711806.
      Citations: 4     Fields:    Translation:HumansCells
    50. Ogasawara T, Okano S, Ichimura H, Kadota S, Tanaka Y, Minami I, Uesugi M, Wada Y, Saito N, Okada K, Kuwahara K, Shiba Y. Impact of extracellular matrix on engraftment and maturation of pluripotent stem cell-derived cardiomyocytes in a rat myocardial infarct model. Sci Rep. 2017 08 17; 7(1):8630. PMID: 28819182; PMCID: PMC5561148.
      Citations: 17     Fields:    Translation:HumansAnimalsCells
    51. Chen IS, Tateyama M, Fukata Y, Uesugi M, Kubo Y. Ivermectin activates GIRK channels in a PIP2 -dependent, G?? -independent manner and an amino acid residue at the slide helix governs the activation. J Physiol. 2017 09 01; 595(17):5895-5912. PMID: 28715108; PMCID: PMC5577542.
      Citations: 15     Fields:    Translation:AnimalsCells
    52. Kawagoe F, Sugiyama T, Uesugi M, Kittaka A. Recent developments for introducing a hexafluoroisopropanol unit into the Vitamin D side chain. J Steroid Biochem Mol Biol. 2018 03; 177:250-254. PMID: 28716761.
      Citations: 2     Fields:    
    53. Kamei KI, Mashimo Y, Yoshioka M, Tokunaga Y, Fockenberg C, Terada S, Koyama Y, Nakajima M, Shibata-Seki T, Liu L, Akaike T, Kobatake E, How SE, Uesugi M, Chen Y. Microfluidic-Nanofiber Hybrid Array for Screening of Cellular Microenvironments. Small. 2017 05; 13(18). PMID: 28272774.
      Citations: 4     Fields:    Translation:HumansAnimalsCells
    54. Asano L, Watanabe M, Ryoden Y, Usuda K, Yamaguchi T, Khambu B, Takashima M, Sato SI, Sakai J, Nagasawa K, Uesugi M. Vitamin D Metabolite, 25-Hydroxyvitamin D, Regulates Lipid Metabolism by Inducing Degradation of SREBP/SCAP. Cell Chem Biol. 2017 Feb 16; 24(2):207-217. PMID: 28132894.
      Citations: 29     Fields:    Translation:HumansAnimalsCells
    55. Mao D, Ando S, Sato SI, Qin Y, Hirata N, Katsuda Y, Kawase E, Kuo TF, Minami I, Shiba Y, Ueda K, Nakatsuji N, Uesugi M. A Synthetic Hybrid Molecule for the Selective Removal of Human Pluripotent Stem Cells from Cell Mixtures. Angew Chem Int Ed Engl. 2017 02 06; 56(7):1765-1770. PMID: 28067441.
      Citations: 4     Fields:    Translation:HumansCells
    56. Katsuda Y, Sato S, Asano L, Morimura Y, Furuta T, Sugiyama H, Hagihara M, Uesugi M. A Small Molecule That Represses Translation of G-Quadruplex-Containing mRNA. J Am Chem Soc. 2016 07 27; 138(29):9037-40. PMID: 27410677.
      Citations: 25     Fields:    Translation:Cells
    57. Sakano D, Choi S, Kataoka M, Shiraki N, Uesugi M, Kume K, Kume S. Dopamine D2 Receptor-Mediated Regulation of Pancreatic ? Cell Mass. Stem Cell Reports. 2016 07 12; 7(1):95-109. PMID: 27373926; PMCID: PMC4944721.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    58. Biswas T, Akagi Y, Usuda K, Yasui K, Shimizu I, Okamoto M, Uesugi M, Hosokawa S, Nagasawa K. Synthesis of 24,24-Difluoro-1,3-cis-25-dihydroxy-19-norvitamin D3 Derivatives and Evaluation of Their Vitamin D Receptor-Binding Affinity. Biol Pharm Bull. 2016; 39(8):1387-91. PMID: 27476947.
      Citations:    Fields:    
    59. Usuda K, Biswas T, Yamaguchi T, Akagi Y, Yasui K, Uesugi M, Shimizu I, Hosokawa S, Nagasawa K. Synthesis of Diastereomers of 1,3-cis-25-Dihydroxy-19-norvitamin D3. Chem Pharm Bull (Tokyo). 2016; 64(8):1190-5. PMID: 27477659.
      Citations:    Fields:    Translation:Cells
    60. Matsumoto Y, Ito A, Uesugi M, Kittaka A. Efficient N-Acyldopamine Synthesis. Chem Pharm Bull (Tokyo). 2016; 64(7):935-40. PMID: 27373649.
      Citations:    Fields:    Translation:Cells
    61. Takaya J, Mio K, Shiraishi T, Kurokawa T, Otsuka S, Mori Y, Uesugi M. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23; 137(50):15859-64. PMID: 26630251.
      Citations: 18     Fields:    Translation:HumansCells
    62. Parvatkar P, Kato N, Uesugi M, Sato S, Ohkanda J. Intracellular Generation of a Diterpene-Peptide Conjugate that Inhibits 14-3-3-Mediated Interactions. J Am Chem Soc. 2015 Dec 23; 137(50):15624-7. PMID: 26632868.
      Citations: 8     Fields:    Translation:HumansCells
    63. Sato S, Watanabe M, Katsuda Y, Murata A, Wang DO, Uesugi M. Live-cell imaging of endogenous mRNAs with a small molecule. Angew Chem Int Ed Engl. 2015 Feb 02; 54(6):1855-8. PMID: 25537455.
      Citations: 16     Fields:    Translation:Cells
    64. Frisco-Cabanos HL, Watanabe M, Okumura N, Kusamori K, Takemoto N, Takaya J, Sato S, Yamazoe S, Takakura Y, Kinoshita S, Nishikawa M, Koizumi N, Uesugi M. Synthetic molecules that protect cells from anoikis and their use in cell transplantation. Angew Chem Int Ed Engl. 2014 Oct 13; 53(42):11208-13. PMID: 25196666.
      Citations: 4     Fields:    Translation:AnimalsCells
    65. Kuo TF, Mao D, Hirata N, Khambu B, Kimura Y, Kawase E, Shimogawa H, Ojika M, Nakatsuji N, Ueda K, Uesugi M. Selective elimination of human pluripotent stem cells by a marine natural product derivative. J Am Chem Soc. 2014 Jul 16; 136(28):9798-801. PMID: 24992689.
      Citations: 9     Fields:    Translation:HumansCells
    66. Hirata N, Nakagawa M, Fujibayashi Y, Yamauchi K, Murata A, Minami I, Tomioka M, Kondo T, Kuo TF, Endo H, Inoue H, Sato SI, Ando S, Kawazoe Y, Aiba K, Nagata K, Kawase E, Chang YT, Suemori H, Eto K, Nakauchi H, Yamanaka S, Nakatsuji N, Ueda K, Uesugi M. A chemical probe that labels human pluripotent stem cells. Cell Rep. 2014 Mar 27; 6(6):1165-1174. PMID: 24613351.
      Citations: 10     Fields:    Translation:HumansAnimalsCells
    67. Araoka T, Mae S, Kurose Y, Uesugi M, Ohta A, Yamanaka S, Osafune K. Efficient and rapid induction of human iPSCs/ESCs into nephrogenic intermediate mesoderm using small molecule-based differentiation methods. PLoS One. 2014; 9(1):e84881. PMID: 24454758; PMCID: PMC3893162.
      Citations: 46     Fields:    Translation:HumansAnimalsCells
    68. Sakano D, Shiraki N, Kikawa K, Yamazoe T, Kataoka M, Umeda K, Araki K, Mao D, Matsumoto S, Nakagata N, Andersson O, Stainier D, Endo F, Kume K, Uesugi M, Kume S. VMAT2 identified as a regulator of late-stage ?-cell differentiation. Nat Chem Biol. 2014 Feb; 10(2):141-8. PMID: 24316738.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    69. Hirayama Y, Yoneda K, Yamagishi K, Chinen T, Usui T, Sumiya E, Uesugi M, Kigoshi H, Kita M. Inhibition of microtubule assembly by a complex of actin and antitumor macrolide aplyronine A. J Am Chem Soc. 2013 Dec 04; 135(48):18089-95. PMID: 24228690.
      Citations: 12     Fields:    Translation:HumansCells
    70. Takemoto N, Suehara T, Frisco HL, Sato S, Sezaki T, Kusamori K, Kawazoe Y, Park SM, Yamazoe S, Mizuhata Y, Inoue R, Miller GJ, Hansen SU, Jayson GC, Gardiner JM, Kanaya T, Tokitoh N, Ueda K, Takakura Y, Kioka N, Nishikawa M, Uesugi M. Small-molecule-induced clustering of heparan sulfate promotes cell adhesion. J Am Chem Soc. 2013 Jul 31; 135(30):11032-9. PMID: 23822587.
      Citations: 7     Fields:    Translation:HumansAnimalsCells
    71. Natsume A, Ito M, Katsushima K, Ohka F, Hatanaka A, Shinjo K, Sato S, Takahashi S, Ishikawa Y, Takeuchi I, Shimogawa H, Uesugi M, Okano H, Kim SU, Wakabayashi T, Issa JP, Sekido Y, Kondo Y. Chromatin regulator PRC2 is a key regulator of epigenetic plasticity in glioblastoma. Cancer Res. 2013 Jul 15; 73(14):4559-70. PMID: 23720055.
      Citations: 42     Fields:    Translation:HumansAnimalsCells
    72. Kumagai H, Suemori H, Uesugi M, Nakatsuji N, Kawase E. Identification of small molecules that promote human embryonic stem cell self-renewal. Biochem Biophys Res Commun. 2013 May 17; 434(4):710-6. PMID: 23541943.
      Citations: 6     Fields:    Translation:HumansAnimalsCells
    73. Jung D, Abu-Elheiga L, Ayuzawa R, Gu Z, Shirakawa T, Fujiki Y, Nakatsuji N, Wakil SJ, Uesugi M. Mislocalization and inhibition of acetyl-CoA carboxylase 1 by a synthetic small molecule. Biochem J. 2012 Dec 15; 448(3):409-16. PMID: 23067267.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    74. Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29; 2(5):1448-60. PMID: 23103164.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    75. Uesugi M. [Control and analysis of cells by synthetic small molecules]. Yakugaku Zasshi. 2012; 132(5):575-86. PMID: 22687693.
      Citations:    Fields:    Translation:HumansAnimalsCells
    76. Khambu B, Uesugi M, Kawazoe Y. Translational repression stabilizes messenger RNA of autophagy-related genes. Genes Cells. 2011 Aug; 16(8):857-67. PMID: 21790910.
      Citations: 2     Fields:    Translation:HumansCells
    77. Kamisuki S, Shirakawa T, Kugimiya A, Abu-Elheiga L, Choo HY, Yamada K, Shimogawa H, Wakil SJ, Uesugi M. Synthesis and evaluation of diarylthiazole derivatives that inhibit activation of sterol regulatory element-binding proteins. J Med Chem. 2011 Jul 14; 54(13):4923-7. PMID: 21561152; PMCID: PMC3136361.
      Citations: 13     Fields:    Translation:AnimalsCells
    78. Kawazoe Y, Shimogawa H, Sato A, Uesugi M. A mitochondrial surface-specific fluorescent probe activated by bioconversion. Angew Chem Int Ed Engl. 2011 Jun 06; 50(24):5478-81. PMID: 21542076.
      Citations: 8     Fields:    Translation:HumansCells
    79. Murata A, Sato S, Kawazoe Y, Uesugi M. Small-molecule fluorescent probes for specific RNA targets. Chem Commun (Camb). 2011 Apr 28; 47(16):4712-4. PMID: 21412566.
      Citations: 16     Fields:    Translation:Cells
    80. Murakami G, Inoue H, Tsukita K, Asai Y, Amagai Y, Aiba K, Shimogawa H, Uesugi M, Nakatsuji N, Takahashi R. Chemical library screening identifies a small molecule that downregulates SOD1 transcription for drugs to treat amyotrophic lateral sclerosis. J Biomol Screen. 2011 Apr; 16(4):405-14. PMID: 21364087.
      Citations: 3     Fields:    Translation:HumansCells
    81. Sumiya E, Shimogawa H, Sasaki H, Tsutsumi M, Yoshita K, Ojika M, Suenaga K, Uesugi M. Cell-morphology profiling of a natural product library identifies bisebromoamide and miuraenamide A as actin filament stabilizers. ACS Chem Biol. 2011 May 20; 6(5):425-31. PMID: 21322638.
      Citations: 18     Fields:    Translation:HumansCells
    82. Sato S, Murata A, Orihara T, Shirakawa T, Suenaga K, Kigoshi H, Uesugi M. Marine natural product aurilide activates the OPA1-mediated apoptosis by binding to prohibitin. Chem Biol. 2011 Jan 28; 18(1):131-9. PMID: 21276946.
      Citations: 41     Fields:    Translation:HumansCells
    83. Shirakawa T, Kawazoe Y, Tsujikawa T, Jung D, Sato S, Uesugi M. Deactivation of STAT6 through serine 707 phosphorylation by JNK. J Biol Chem. 2011 Feb 04; 286(5):4003-10. PMID: 21123173; PMCID: PMC3030400.
      Citations: 13     Fields:    Translation:HumansCells
    84. Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M. A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs. Oncotarget. 2010 Aug; 1(4):252-64. PMID: 21304177; PMCID: PMC3248105.
      Citations: 15     Fields:    Translation:HumansAnimalsCells
    85. Sato S, Murata A, Shirakawa T, Uesugi M. Biochemical target isolation for novices: affinity-based strategies. Chem Biol. 2010 Jun 25; 17(6):616-23. PMID: 20609411.
      Citations: 23     Fields:    Translation:HumansAnimalsCells
    86. Hoshino M, Tsujimoto T, Yamazoe S, Uesugi M, Terada S. Adhesamine, a new synthetic molecule, accelerates differentiation and prolongs survival of primary cultured mouse hippocampal neurons. Biochem J. 2010 Mar 29; 427(2):297-304. PMID: 20146670.
      Citations:    Fields:    Translation:AnimalsCells
    87. Kamisuki S, Mao Q, Abu-Elheiga L, Gu Z, Kugimiya A, Kwon Y, Shinohara T, Kawazoe Y, Sato S, Asakura K, Choo HY, Sakai J, Wakil SJ, Uesugi M. A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. Chem Biol. 2009 Aug 28; 16(8):882-92. PMID: 19716478.
      Citations: 104     Fields:    Translation:HumansAnimalsCells
    88. Yamazoe S, Shimogawa H, Sato S, Esko JD, Uesugi M. A dumbbell-shaped small molecule that promotes cell adhesion and growth. Chem Biol. 2009 07 31; 16(7):773-82. PMID: 19635414.
      Citations: 3     Fields:    Translation:HumansCells
    89. Jung D, Shimogawa H, Kwon Y, Mao Q, Sato S, Kamisuki S, Kigoshi H, Uesugi M. Wrenchnolol derivative optimized for gene activation in cells. J Am Chem Soc. 2009 Apr 08; 131(13):4774-82. PMID: 19290630.
      Citations: 8     Fields:    Translation:HumansCells
    90. Shinohara T, Uesugi M. [In-vivo activation of the p53 pathway by small-molecule antagonists of MDM2]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1816-7. PMID: 18051440.
      Citations: 3     Fields:    Translation:HumansAnimalsCells
    91. Kamisuki S, Uesugi M. [Discovering high-affinity ligands for proteins: SAR by NMR]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1818-9. PMID: 18051441.
      Citations:    Fields:    Translation:Cells
    92. Kugimiya A, Takagi J, Uesugi M. [Role of LXRs in control of lipogenesis]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1814-5. PMID: 18051439.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    93. Sato S, Murata A, Uesugi M. [Identification of the cardiac beta-adrenergic receptor protein: solubilization and purification by affinity chromatography]. Tanpakushitsu Kakusan Koso. 2007 Oct; 52(13 Suppl):1782-3. PMID: 18051424.
      Citations:    Fields:    Translation:HumansAnimals
    94. Sato S, Kwon Y, Kamisuki S, Srivastava N, Mao Q, Kawazoe Y, Uesugi M. Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J Am Chem Soc. 2007 Jan 31; 129(4):873-80. PMID: 17243824.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    95. Jung D, Choi Y, Uesugi M. Small organic molecules that modulate gene transcription. Drug Discov Today. 2006 May; 11(9-10):452-7. PMID: 16635809.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    96. Choi Y, Shimogawa H, Murakami K, Ramdas L, Zhang W, Qin J, Uesugi M. Chemical genetic identification of the IGF-linked pathway that is mediated by STAT6 and MFP2. Chem Biol. 2006 Mar; 13(3):241-9. PMID: 16638529.
      Citations: 5     Fields:    Translation:AnimalsCells
    97. Sato A, Kawazoe Y, Kamisuki S, Uesugi M. Synthesis of synthetic small molecule transcription factors (STF). Nucleic Acids Symp Ser (Oxf). 2006; (50):29-30. PMID: 17150801.
      Citations:    Fields:    
    98. Uesugi M. [Small molecules that control gene expression]. Seikagaku. 2005 Sep; 77(9):1177-80. PMID: 16241004.
      Citations:    Fields:    Translation:HumansCells
    99. Kawazoe Y, Uesugi M. [Trends in chemical libraries for chemical genetics]. Tanpakushitsu Kakusan Koso. 2005 Aug; 50(9):1043-8. PMID: 16083041.
      Citations:    Fields:    Translation:Animals
    100. Kwon Y, Arndt HD, Mao Q, Choi Y, Kawazoe Y, Dervan PB, Uesugi M. Small molecule transcription factor mimic. J Am Chem Soc. 2004 Dec 15; 126(49):15940-1. PMID: 15584709.
      Citations: 23     Fields:    Translation:Humans
    101. Uesugi M. Synthetic molecules that modulate transcription and differentiation: hints for future drug discovery. Comb Chem High Throughput Screen. 2004 Nov; 7(7):653-9. PMID: 15578927.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    102. Kawazoe Y, Tanaka S, Uesugi M. Chemical genetic identification of the histamine H1 receptor as a stimulator of insulin-induced adipogenesis. Chem Biol. 2004 Jul; 11(7):907-13. PMID: 15271349.
      Citations: 3     Fields:    Translation:AnimalsCells
    103. Shimogawa H, Kwon Y, Mao Q, Kawazoe Y, Choi Y, Asada S, Kigoshi H, Uesugi M. A wrench-shaped synthetic molecule that modulates a transcription factor-coactivator interaction. J Am Chem Soc. 2004 Mar 24; 126(11):3461-71. PMID: 15025473.
      Citations: 16     Fields:    Translation:HumansCells
    104. Asada S, Choi Y, Uesugi M. A gene-expression inhibitor that targets an alpha-helix-mediated protein interaction. J Am Chem Soc. 2003 Apr 30; 125(17):4992-3. PMID: 12708845.
      Citations: 10     Fields:    Translation:Cells
    105. Choi Y, Kawazoe Y, Murakami K, Misawa H, Uesugi M. Identification of bioactive molecules by adipogenesis profiling of organic compounds. J Biol Chem. 2003 Feb 28; 278(9):7320-4. PMID: 12496288.
      Citations: 19     Fields:    Translation:HumansAnimalsCells
    106. Asada S, Choi Y, Yamada M, Wang SC, Hung MC, Qin J, Uesugi M. External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator. Proc Natl Acad Sci U S A. 2002 Oct 01; 99(20):12747-52. PMID: 12242338; PMCID: PMC130531.
      Citations: 25     Fields:    Translation:HumansCells
    UESUGI's Networks
    Click the
    Explore
    buttons for more information and interactive visualizations!
    Concepts (510)
    Explore
    _
    Co-Authors (1)
    Explore
    _
    Similar People (60)
    Explore
    _
    Same Department Expand Description
    Explore
    _
    Physical Neighbors
    _