NALINA LI0.000000000000000.000000000000004364LI, NAProfessorprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25389315Chiang DY, Kongchan N, Beavers DL, Alsina KM, Voigt N, Neilson JR, Jakob H, Martin JF, Dobrev D, Wehrens XH, Li NCirculation. Arrhythmia and electrophysiologyLoss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release. Circ Arrhythm Electrophysiol. 2014 Dec; 7(6):1214-22.Circ Arrhythm Electrophysiol2014-11-11T00:00:002014Loss of microRNA-106b-25 cluster promotes atrial fibrillation by enhancing ryanodine receptor type-2 expression and calcium release.Authorship 15849011Authorship 1144541Authorship 444637Authorship 261840925706326Chiang DY, Zhang M, Voigt N, Alsina KM, Jakob H, Martin JF, Dobrev D, Wehrens XHT, Li NInternational journal of cardiologyIdentification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation. Int J Cardiol. 2015 Apr 01; 184:190-197.Int J Cardiol2015-01-28T00:00:002015Identification of microRNA-mRNA dysregulations in paroxysmal atrial fibrillation.Authorship 865622NANBINGLI-VILLARREALNANBING LI-VILLARREAL10361LI-VILLARREAL, NANBINGInstructorAuthorship 2811771Authorship 281178326521064Li NTrends in cardiovascular medicineEditorial Commentary: The emerging role of epigenetics in atrial fibrillation. Trends Cardiovasc Med. 2016 May; 26(4):319-20.Trends Cardiovasc Med2015-10-03T00:00:002015Editorial Commentary: The emerging role of epigenetics in atrial fibrillation.26075818Xie L, Pi X, Townley-Tilson WH, Li N, Wehrens XH, Entman ML, Taffet GE, Mishra A, Peng J, Schisler JC, Meissner G, Patterson CThe Journal of clinical investigationPHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban. J Clin Invest. 2015 Jul 01; 125(7):2759-71.J Clin Invest2015-06-15T00:00:002015PHD2/3-dependent hydroxylation tunes cardiac response to ?-adrenergic stress via phospholamban.26162324Glasscock E, Voigt N, McCauley MD, Sun Q, Li N, Chiang DY, Zhou XB, Molina CE, Thomas D, Schmidt C, Skapura DG, Noebels JL, Dobrev D, Wehrens XHBasic research in cardiologyExpression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation. Basic Res Cardiol. 2015 Sep; 110(5):505.Basic Res Cardiol2015-07-11T00:00:002015Expression and function of Kv1.1 potassium channels in human atria from patients with atrial fibrillation.74Professor54Instructor14Associate Professor16Associate Professor Emeritus46Distinguished Emeritus Professor102Visiting Professor3Adjunct Associate Professor88Senior Faculty6Adjunct ProfessorAuthorship 320574126782118Li N, Dobrev D, Wehrens XHCardiovascular researchPITX2: a master regulator of cardiac channelopathy in atrial fibrillation? Cardiovasc Res. 2016 Mar 01; 109(3):345-7.Cardiovasc Res2016-01-17T00:00:002016PITX2: a master regulator of cardiac channelopathy in atrial fibrillation?26818679Schulte JS, Fehrmann E, Tekook MA, Kranick D, Fels B, Li N, Wehrens XH, Heinick A, Seidl MD, Schmitz W, M?ller FUBasic research in cardiologyCardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes. Basic Res Cardiol. 2016 Mar; 111(2):15.Basic Res Cardiol2016-01-27T00:00:002016Cardiac expression of the CREM repressor isoform CREM-Ib?C-X in mice leads to arrhythmogenic alterations in ventricular cardiomyocytes.27318036Uchinoumi H, Yang Y, Oda T, Li N, Alsina KM, Puglisi JL, Chen-Izu Y, Cornea RL, Wehrens XHT, Bers DMJournal of molecular and cellular cardiologyCaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift. J Mol Cell Cardiol. 2016 09; 98:62-72.J Mol Cell Cardiol2016-06-16T00:00:002016CaMKII-dependent phosphorylation of RyR2 promotes targetable pathological RyR2 conformational shift.One Baylor PlazaHouston, 77030TX23246599Ather S, Wang W, Wang Q, Li N, Anderson ME, Wehrens XHHeart rhythmInhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy. Heart Rhythm. 2013 Apr; 10(4):592-9.Heart Rhythm2012-12-12T00:00:002012Inhibition of CaMKII phosphorylation of RyR2 prevents inducible ventricular arrhythmias in mice with Duchenne muscular dystrophy.19603549Chelu MG, Sarma S, Sood S, Wang S, van Oort RJ, Skapura DG, Li N, Santonastasi M, M?ller FU, Schmitz W, Schotten U, Anderson ME, Valderr?bano M, Dobrev D, Wehrens XHThe Journal of clinical investigationCalmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice. J Clin Invest. 2009 Jul; 119(7):1940-51.J Clin Invest2009-07-01T00:00:002009Calmodulin kinase II-mediated sarcoplasmic reticulum Ca2+ leak promotes atrial fibrillation in mice.Authorship 6528371Authorship 654281127838126Li N, Wang Q, Sibrian-Vazquez M, Klipp RC, Reynolds JO, Word TA, Scott L, Salama G, Strongin RM, Abramson JJ, Wehrens XHTInternational journal of cardiologyTreatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs. Int J Cardiol. 2017 Jan 15; 227:668-673.Int J Cardiol2016-10-29T00:00:002016Treatment of catecholaminergic polymorphic ventricular tachycardia in mice using novel RyR2-modifying drugs.27993379Li N, Dobrev DInternational journal of cardiologyHyperuricemia: A causal player or a bystander linking inflammatory signaling and atrial fibrillation? Int J Cardiol. 2017 Mar 15; 231:177-178.Int J Cardiol2016-12-06T00:00:002016Hyperuricemia: A causal player or a bystander linking inflammatory signaling and atrial fibrillation?20009080Mathur N, Sood S, Wang S, van Oort RJ, Sarma S, Li N, Skapura DG, Bayle JH, Valderr?bano M, Wehrens XHCirculation. Arrhythmia and electrophysiologySudden infant death syndrome in mice with an inherited mutation in RyR2. Circ Arrhythm Electrophysiol. 2009 Dec; 2(6):677-85.Circ Arrhythm Electrophysiol2009-12-01T00:00:002009Sudden infant death syndrome in mice with an inherited mutation in RyR2.20615971Sarma S, Li N, van Oort RJ, Reynolds C, Skapura DG, Wehrens XHProceedings of the National Academy of Sciences of the United States of AmericaGenetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy. Proc Natl Acad Sci U S A. 2010 Jul 20; 107(29):13165-70.Proc Natl Acad Sci U S A2010-07-06T00:00:002010Genetic inhibition of PKA phosphorylation of RyR2 prevents dystrophic cardiomyopathy.21859974Cunha SR, Hund TJ, Hashemi S, Voigt N, Li N, Wright P, Koval O, Li J, Gudmundsson H, Gumina RJ, Karck M, Schott JJ, Probst V, Le Marec H, Anderson ME, Dobrev D, Wehrens XH, Mohler PJCirculationDefects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation. Circulation. 2011 Sep 13; 124(11):1212-22.Circulation2011-08-22T00:00:002011Defects in ankyrin-based membrane protein targeting pathways underlie atrial fibrillation.22158709Li N, Wang T, Wang W, Cutler MJ, Wang Q, Voigt N, Rosenbaum DS, Dobrev D, Wehrens XHCirculation researchInhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice. Circ Res. 2012 Feb 03; 110(3):465-70.Circ Res2011-12-08T00:00:002011Inhibition of CaMKII phosphorylation of RyR2 prevents induction of atrial fibrillation in FKBP12.6 knockout mice.23059182DeGrande S, Nixon D, Koval O, Curran JW, Wright P, Wang Q, Kashef F, Chiang D, Li N, Wehrens XH, Anderson ME, Hund TJ, Mohler PJHeart rhythmCaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome. Heart Rhythm. 2012 Dec; 9(12):2034-41.Heart Rhythm2012-08-28T00:00:002012CaMKII inhibition rescues proarrhythmic phenotypes in the model of human ankyrin-B syndrome.Authorship 100433122093963Kirchhof P, Marijon E, Fabritz L, Li N, Wang W, Wang T, Schulte K, Hanstein J, Schulte JS, Vogel M, Mougenot N, Laakmann S, Fortmueller L, Eckstein J, Verheule S, Kaese S, Staab A, Grote-Wessels S, Schotten U, Moubarak G, Wehrens XH, Schmitz W, Hatem S, M?ller FUInternational journal of cardiologyOverexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice. Int J Cardiol. 2013 Jun 20; 166(2):366-74.Int J Cardiol2011-11-16T00:00:002011Overexpression of cAMP-response element modulator causes abnormal growth and development of the atrial myocardium resulting in a substrate for sustained atrial fibrillation in mice.22456474Voigt N, Li N, Wang Q, Wang W, Trafford AW, Abu-Taha I, Sun Q, Wieland T, Ravens U, Nattel S, Wehrens XH, Dobrev DCirculationEnhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation. Circulation. 2012 May 01; 125(17):2059-70.Circulation2012-03-28T00:00:002012Enhanced sarcoplasmic reticulum Ca2+ leak and increased Na+-Ca2+ exchanger function underlie delayed afterdepolarizations in patients with chronic atrial fibrillation.22511749Respress JL, van Oort RJ, Li N, Rolim N, Dixit SS, deAlmeida A, Voigt N, Lawrence WS, Skapura DG, Sk?rdal K, Wisl?ff U, Wieland T, Ai X, Pogwizd SM, Dobrev D, Wehrens XHCirculation researchRole of RyR2 phosphorylation at S2814 during heart failure progression. Circ Res. 2012 May 25; 110(11):1474-83.Circ Res2012-04-17T00:00:002012Role of RyR2 phosphorylation at S2814 during heart failure progression.20157052van Oort RJ, Respress JL, Li N, Reynolds C, De Almeida AC, Skapura DG, De Windt LJ, Wehrens XHHypertension (Dallas, Tex. : 1979)Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model. Hypertension. 2010 Apr; 55(4):932-8.Hypertension2010-02-15T00:00:002010Accelerated development of pressure overload-induced cardiac hypertrophy and dysfunction in an RyR2-R176Q knockin mouse model.20512106Li N, Wehrens XHJournal of visualized experiments : JoVEProgrammed electrical stimulation in mice. J Vis Exp. 2010 May 26; (39).J Vis Exp2010-05-26T00:00:002010Programmed electrical stimulation in mice.23085093Li N, Wehrens XHHeart rhythmExtinguishing intracellular calcium leak: a promising antiarrhythmic approach. Heart Rhythm. 2013 Jan; 10(1):108-9.Heart Rhythm2012-10-17T00:00:002012Extinguishing intracellular calcium leak: a promising antiarrhythmic approach.Authorship 8823217Authorship 883772129248564Klipp RC, Li N, Wang Q, Word TA, Sibrian-Vazquez M, Strongin RM, Wehrens XHT, Abramson JJHeart rhythmEL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2. Heart Rhythm. 2018 04; 15(4):578-586.Heart Rhythm2017-12-14T00:00:002017EL20, a potent antiarrhythmic compound, selectively inhibits calmodulin-deficient ryanodine receptor type 2.29327256Li N, Dobrev DNaunyn-Schmiedeberg's archives of pharmacologyTargeting atrial fibrillation promoting atrial structural remodeling: is this a viable strategy in patients with heart failure? Naunyn Schmiedebergs Arch Pharmacol. 2018 03; 391(3):231-233.Naunyn Schmiedebergs Arch Pharmacol2018-01-11T00:00:002018Targeting atrial fibrillation promoting atrial structural remodeling: is this a viable strategy in patients with heart failure?29654126Wang Q, Quick AP, Cao S, Reynolds J, Chiang DY, Beavers D, Li N, Wang G, Rodney GG, Anderson ME, Wehrens XHTCirculation. Arrhythmia and electrophysiologyOxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy. Circ Arrhythm Electrophysiol. 2018 04; 11(4):e005682.Circ Arrhythm Electrophysiol2018-04-01T00:00:002018Oxidized CaMKII (Ca2+/Calmodulin-Dependent Protein Kinase II) Is Essential for Ventricular Arrhythmia in a Mouse Model of Duchenne Muscular Dystrophy.23363625Pereira L, Cheng H, Lao DH, Na L, van Oort RJ, Brown JH, Wehrens XH, Chen J, Bers DMCirculationEpac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia. Circulation. 2013 Feb 26; 127(8):913-22.Circulation2013-01-30T00:00:002013Epac2 mediates cardiac ?1-adrenergic-dependent sarcoplasmic reticulum Ca2+ leak and arrhythmia.true1ProfessorProfessortrue1ProfessorProfessorAuthorship 102327129881800Lai YC, Li N, Lawrence W, Wang S, Levine A, Burchhardt DM, Pautler RG, Valderr?bano M, Wehrens XH, Anderson AEEpilepsia openMyocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy. Epilepsia Open. 2018 Jun; 3(2):213-223.Epilepsia Open2018-03-23T00:00:002018Myocardial remodeling and susceptibility to ventricular tachycardia in a model of chronic epilepsy.D001281Disorders2397140.570562Atrial FibrillationD032383Anatomy2057940.643137Myocytes, CardiacD002118Chemicals & Drugs52915430.610829CalciumCHRISTINAMIYAKECHRISTINA MIYAKE0.000000000000000.000000000000005520MIYAKE, CHRISTINAAssociate ProfessorD019837Chemicals & Drugs622440.817509Ryanodine Receptor Calcium Release ChannelAuthorship 9164684Authorship 92987221Authorship 9318812Authorship 9337742Authorship 93802710Authorship 940162730150941Chen G, Chelu MG, Dobrev D, Li NFrontiers in physiologyCardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications. Front Physiol. 2018; 9:1115.Front Physiol2018-08-13T00:00:002018Cardiomyocyte Inflammasome Signaling in Cardiomyopathies and Atrial Fibrillation: Mechanisms and Potential Therapeutic Implications.29802206Yao C, Veleva T, Scott L, Cao S, Li L, Chen G, Jeyabal P, Pan X, Alsina KM, Abu-Taha I, Ghezelbash S, Reynolds CL, Shen YH, LeMaire SA, Schmitz W, M?ller FU, El-Armouche A, Tony Eissa N, Beeton C, Nattel S, Wehrens XHT, Dobrev D, Li NCirculationEnhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation. Circulation. 2018 11 13; 138(20):2227-2242.Circulation2018-11-13T00:00:002018Enhanced Cardiomyocyte NLRP3 Inflammasome Signaling Promotes Atrial Fibrillation.30316645Scott L, Li N, Dobrev DInternational journal of cardiologyRole of inflammatory signaling in atrial fibrillation. Int J Cardiol. 2019 07 15; 287:195-200.Int J Cardiol2018-10-04T00:00:002018Role of inflammatory signaling in atrial fibrillation.30355031Pan X, Philippen L, Lahiri SK, Lee C, Park SH, Word TA, Li N, Jarrett KE, Gupta R, Reynolds JO, Lin J, Bao G, Lagor WR, Wehrens XHTCirculation researchIn Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia. Circ Res. 2018 Sep 28; 123(8):953-963.Circ Res2018-09-28T00:00:002018In Vivo Ryr2 Editing Corrects Catecholaminergic Polymorphic Ventricular Tachycardia.30582449Ni L, Scott L, Campbell HM, Pan X, Alsina KM, Reynolds J, Philippen LE, Hulsurkar M, Lagor WR, Li N, Wehrens XHTCirculation researchAtrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector. Circ Res. 2019 01 18; 124(2):256-262.Circ Res2019-01-18T00:00:002019Atrial-Specific Gene Delivery Using an Adeno-Associated Viral Vector.2026-11-30NIHLI, NA2017-09-01The Role of Gasdermin-D/Interleukin-1 Nexus in Atrial ArrhythmogenesisR01HL1363892018-08-31NIHLI, NA2016-09-16Inflammasome mediated pathogenesis of atrial fibrillationR56HL131649Principal InvestigatorPrincipal InvestigatorDepartment of MedicineDepartment of PediatricsMedicine-Athero & LipoproteinsMedicine-CardiologyMedicine-General MedicineMedicine-NephrologyMolecular Physiology & BiophysicsPediatrics-CardiologyBaylor College of MedicineFRANKHORRIGANFRANK HORRIGAN0.000000000000000.000000000000001467HORRIGAN, FRANKAssociate ProfessorYOCHAIBIRNBAUMYOCHAI BIRNBAUM0.000000000000000.000000000000001504BIRNBAUM, YOCHAIProfessorJOELMORRISETTJOEL MORRISETT0.000000000000000.000000000000002449MORRISETT, JOELDistinguished Emeritus ProfessorPETERJONESPETER JONES0.000000000000000.000000000000002402JONES, PETERAssociate Professor Emeritus8.199260.00682959337research areas11.69640.034006941coauthor of262.13112.425360similar to1178selected publicationsERICBOERWINKLEERIC BOERWINKLE0.000000000000000.000000000000002653BOERWINKLE, ERICAdjunct ProfessorELIZABETHVAUGHANELIZABETH VAUGHAN0.000000000000000.000000000000004576VAUGHAN, ELIZABETHAdjunct Associate ProfessorJAMESJONESJAMES JONES0.000000000000000.000000000000003032JONES, JAMESVisiting ProfessorXANDERWEHRENSXANDER WEHRENS0.000000000000000.00000000000000964WEHRENS, XANDERProfessor2024-02-29NIHLI, NA ;WEHRENS, XANDER H.T.2019-04-15Mechanisms underlying atrial fibrillation associated with chronic kidney diseaseR01HL147108Co-Principal InvestigatorAuthorship 1258813Authorship 12737913D058847Chemicals & Drugs781610.838599Inflammasomes23583764Wehrens XH, Chiang DY, Li NJournal of the American College of CardiologyChronic exercise: a contributing factor to atrial fibrillation? J Am Coll Cardiol. 2013 Jul 02; 62(1):78-80.J Am Coll Cardiol2013-04-09T00:00:002013Chronic exercise: a contributing factor to atrial fibrillation?24030498Purohit A, Rokita AG, Guan X, Chen B, Koval OM, Voigt N, Neef S, Sowa T, Gao Z, Luczak ED, Stefansdottir H, Behunin AC, Li N, El-Accaoui RN, Yang B, Swaminathan PD, Weiss RM, Wehrens XH, Song LS, Dobrev D, Maier LS, Anderson MECirculationOxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation. Circulation. 2013 Oct 15; 128(16):1748-57.Circulation2013-09-12T00:00:002013Oxidized Ca(2+)/calmodulin-dependent protein kinase II triggers atrial fibrillation.Authorship 9489551431185731Alsina KM, Hulsurkar M, Brandenburg S, Kownatzki-Danger D, Lenz C, Urlaub H, Abu-Taha I, Kamler M, Chiang DY, Lahiri SK, Reynolds JO, Quick AP, Scott L, Word TA, Gelves MD, Heck AJR, Li N, Dobrev D, Lehnart SE, Wehrens XHTCirculationLoss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation. Circulation. 2019 08 20; 140(8):681-693.Circulation2019-06-12T00:00:002019Loss of Protein Phosphatase 1 Regulatory Subunit PPP1R3A Promotes Atrial Fibrillation.Authorship 952849231353152Suryavanshi SV, Li NInternational journal of cardiologyBeh?et's disease: A (silk) route to atrial fibrillation? Int J Cardiol. 2019 10 15; 293:117-118.Int J Cardiol2019-07-19T00:00:002019Beh?et's disease: A (silk) route to atrial fibrillation?31622781Greer-Short A, Musa H, Alsina KM, Ni L, Word TA, Reynolds JO, Gratz D, Lane C, El-Refaey M, Unudurthi S, Skaf M, Li N, Fedorov VV, Wehrens XHT, Mohler PJ, Hund TJHeart rhythmCalmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia. Heart Rhythm. 2020 03; 17(3):503-511.Heart Rhythm2019-10-14T00:00:002019Calmodulin kinase II regulates atrial myocyte late sodium current, calcium handling, and atrial arrhythmia.31636200Zhang M, Hill MC, Kadow ZA, Suh JH, Tucker NR, Hall AW, Tran TT, Swinton PS, Leach JP, Margulies KB, Ellinor PT, Li N, Martin JFProceedings of the National Academy of Sciences of the United States of AmericaLong-range Pitx2c enhancer-promoter interactions prevent predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2019 11 05; 116(45):22692-22698.Proc Natl Acad Sci U S A2019-10-21T00:00:002019Long-range Pitx2c enhancer-promoter interactions prevent predisposition to atrial fibrillation.true1Senior FacultySenior FacultyMIHAILCHELUMIHAIL CHELU15434CHELU, MIHAILSenior Faculty29885821Chelu MG, Li NInternational journal of cardiologyBiomarkers (plasma trimethylamine-N-oxide) to predict atrial fibrillation: Are we there yet? Int J Cardiol. 2018 09 15; 267:116-117.Int J Cardiol2018-05-30T00:00:002018Biomarkers (plasma trimethylamine-N-oxide) to predict atrial fibrillation: Are we there yet?30144996Chelu MG, Li NInternational journal of cardiology"Sorting" SERCA2a: A novel therapeutic strategy in heart failure? Int J Cardiol. 2018 12 01; 272:306-307.Int J Cardiol2018-08-18T00:00:002018"Sorting" SERCA2a: A novel therapeutic strategy in heart failure?Authorship 979210232173053Scott L, Li NThe Canadian journal of cardiologyFrom Neutrophil Calcium Sensor to Myocardial Remodelling-A Double-Edged Pathway Guided by the Inflammasome. Can J Cardiol. 2020 06; 36(6):813-815.Can J Cardiol2019-11-04T00:00:002019From Neutrophil Calcium Sensor to Myocardial Remodelling-A Double-Edged Pathway Guided by the Inflammasome.true1Adjunct ProfessorAdjunct ProfessorAuthorship 1296051Authorship 1296064Authorship 1296084Authorship 1296094Authorship 1296101Authorship 1296112Authorship 1296121Authorship 1296131Authorship 1296143Authorship 1296155Authorship 129616220529095Li N, Jia N, Dai DZ, Hu C, Dai YClinical and experimental pharmacology & physiologyRole of endothelin in the effects of isoprenaline on potassium currents and calsequestrin 2 expression in the heart. Clin Exp Pharmacol Physiol. 2010 May; 37(5-6):557-63.Clin Exp Pharmacol Physiol2010-05-01T00:00:002010Role of endothelin in the effects of isoprenaline on potassium currents and calsequestrin 2 expression in the heart.20139899Qi MY, Feng Y, Dai DZ, Li N, Cheng YS, Dai YActa pharmacologica SinicaCPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity. Acta Pharmacol Sin. 2010 Feb; 31(2):165-74.Acta Pharmacol Sin2010-02-01T00:00:002010CPU86017, a berberine derivative, attenuates cardiac failure through normalizing calcium leakage and downregulated phospholamban and exerting antioxidant activity.19000375Qi MY, Liu HR, Dai DZ, Li N, Dai YThe Journal of pharmacy and pharmacologyTotal triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats. J Pharm Pharmacol. 2008 Dec; 60(12):1687-94.J Pharm Pharmacol2008-12-01T00:00:002008Total triterpene acids, active ingredients from Fructus Corni, attenuate diabetic cardiomyopathy by normalizing ET pathway and expression of FKBP12.6 and SERCA2a in streptozotocin-rats.18986320Cui B, Cheng YS, Dai DZ, Li N, Zhang TT, Dai YClinical and experimental pharmacology & physiologyCPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats. Clin Exp Pharmacol Physiol. 2009 Feb; 36(2):169-75.Clin Exp Pharmacol Physiol2008-10-17T00:00:002008CPU0213, a non-selective ETA/ETB receptor antagonist, improves pulmonary arteriolar remodeling of monocrotaline-induced pulmonary hypertension in rats.18611397Li N, Jia N, Dai DZ, Dai YEuropean journal of pharmacologyEndothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon. Eur J Pharmacol. 2008 Sep 04; 591(1-3):211-8.Eur J Pharmacol2008-06-27T00:00:002008Endothelin receptor antagonist CPU0213 and vitamin E reverse downregulation of FKBP12.6 and SERCA2a: a role of hyperphosphorylation of PKCepsilon.18594475Xu J, Li N, Dai DZ, Yu F, Dai YJournal of cardiovascular pharmacologyThe endothelin receptor antagonist CPU0213 is more effective than aminoguanidine to attenuate isoproterenol-induced vascular abnormality by suppressing overexpression of NADPH oxidase [correction of oxidas], ETA, ETB, and MMP9 in the vasculature. J Cardiovasc Pharmacol. 2008 Jul; 52(1):42-8.J Cardiovasc Pharmacol2008-07-01T00:00:002008The endothelin receptor antagonist CPU0213 is more effective than aminoguanidine to attenuate isoproterenol-induced vascular abnormality by suppressing overexpression of NADPH oxidase [correction of oxidas], ETA, ETB, and MMP9 in the vasculature.18548232Li N, Dai DZ, Dai YNaunyn-Schmiedeberg's archives of pharmacologyCPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation. Naunyn Schmiedebergs Arch Pharmacol. 2008 Nov; 378(5):541-52.Naunyn Schmiedebergs Arch Pharmacol2008-06-12T00:00:002008CPU86017 and its isomers improve hypoxic pulmonary hypertension by attenuating increased ETA receptor expression and extracellular matrix accumulation.18177475Li N, Yang L, Dai DZ, Wang QJ, Dai YClinical and experimental pharmacology & physiologyChiral separation of racemate CPU86017, an anti-arrhythmic agent, produces stereoisomers possessing favourable ion channel blockade and less alpha-adrenoceptor antagonism. Clin Exp Pharmacol Physiol. 2008 May; 35(5-6):643-50.Clin Exp Pharmacol Physiol2007-12-27T00:00:002007Chiral separation of racemate CPU86017, an anti-arrhythmic agent, produces stereoisomers possessing favourable ion channel blockade and less alpha-adrenoceptor antagonism.17324143Huang ZJ, Dai DZ, Li N, Na T, Ji M, Dai YClinical and experimental pharmacology & physiologyCalcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits. Clin Exp Pharmacol Physiol. 2007 Apr; 34(4):310-7.Clin Exp Pharmacol Physiol2007-04-01T00:00:002007Calcium antagonist property of CPU228, a dofetilide derivative, contributes to its low incidence of torsades de pointes in rabbits.24249718Voigt N, Heijman J, Wang Q, Chiang DY, Li N, Karck M, Wehrens XHT, Nattel S, Dobrev DCirculationCellular and molecular mechanisms of atrial arrhythmogenesis in patients with paroxysmal atrial fibrillation. 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Cardiovasc Res. 2023 05 02; 119(3):614-630.Cardiovasc Res2023-05-02T00:00:002023Adiposity-associated atrial fibrillation: molecular determinants, mechanisms, and clinical significance.true1InstructorInstructortrue1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorDepartment of Integrative Physiologytrue1Associate ProfessorAssociate Professortrue1Visiting ProfessorVisiting ProfessorAuthorship 10577491036473599Miyake CY, Lay EJ, Soler-Alfonso C, Glinton KE, Houck KM, Tosur M, Moran NE, Stephens SB, Scaglia F, Howard TS, Kim JJ, Pham TD, Valdes SO, Li N, Murali CN, Zhang L, Kava M, Yim D, Beach C, Webster G, Liberman L, Janson CM, Kannankeril PJ, Baxter S, Singer-Berk M, Wood J, Mackenzie SJ, Sacher M, Ghaloul-Gonzalez L, Pedroza C, Morris SA, Ehsan SA, Azamian MS, Lalani SRGenetics in medicine : official journal of the American College of Medical GeneticsNatural history of TANGO2 deficiency disorder: Baseline assessment of 73 patients. 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Circulation. 2014 Mar 25; 129(12):1276-1285.Circulation2014-01-07T00:00:002014Ryanodine receptor-mediated calcium leak drives progressive development of an atrial fibrillation substrate in a transgenic mouse model.Authorship 146079224812280Chiang DY, Li N, Wang Q, Alsina KM, Quick AP, Reynolds JO, Wang G, Skapura D, Voigt N, Dobrev D, Wehrens XHCardiovascular researchImpaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation. Cardiovasc Res. 2014 Jul 01; 103(1):178-87.Cardiovasc Res2014-05-08T00:00:002014Impaired local regulation of ryanodine receptor type 2 by protein phosphatase 1 promotes atrial fibrillation.24927531Wang J, Bai Y, Li N, Ye W, Zhang M, Greene SB, Tao Y, Chen Y, Wehrens XH, Martin JFProceedings of the National Academy of Sciences of the United States of AmericaPitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation. Proc Natl Acad Sci U S A. 2014 Jun 24; 111(25):9181-6.Proc Natl Acad Sci U S A2014-06-10T00:00:002014Pitx2-microRNA pathway that delimits sinoatrial node development and inhibits predisposition to atrial fibrillation.Authorship 867273Authorship 66533Authorship 755866