ERGUNSAHINERGUN SAHIN0.000000000000000.000000000000004106SAHIN, ERGUNAssociate Professorplugins:FeaturedVideosFeatured Videosprns:coAuthorOfcoauthor ofprns:emailEncryptedemail addressprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:pluginSearchableDataProfilesRNS Plugin Searchable Dataprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPersonAuthorship 925635Authorship 303175Cancer BiologyCancer Systems ImagingLeukemiaMolecular & Cellular OncologyMD AndersonMIEN-CHIEHUNGMIEN-CHIE HUNG8427HUNG, MIEN-CHIEProfessorSIMONACOLLASIMONA COLLA9790COLLA, SIMONAAssistant ProfessorRONALD ADEPINHORONALD A DEPINHO9729DEPINHO, RONALD AProfessorFLORIANMULLERFLORIAN MULLER9794MULLER, FLORIANAssistant ProfessorAuthorship 902015Authorship 3047051426153864Muller F, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee M, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RANatureCorrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2015 Sep 10; 525(7568):278.Nature2015-07-08T00:00:002015Corrigendum: Passenger deletions generate therapeutic vulnerabilities in cancer.74Professor10Assistant Professor54Instructor21Chair14Associate ProfessorOne Baylor PlazaHouston, 77030TX19050074Kimmelman AC, Hezel AF, Aguirre AJ, Zheng H, Paik JH, Ying H, Chu GC, Zhang JX, Sahin E, Yeo G, Ponugoti A, Nabioullin R, Deroo S, Yang S, Wang X, McGrath JP, Protopopova M, Ivanova E, Zhang J, Feng B, Tsao MS, Redston M, Protopopov A, Xiao Y, Futreal PA, Hahn WC, Klimstra DS, Chin L, DePinho RAProceedings of the National Academy of Sciences of the United States of AmericaGenomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer. Proc Natl Acad Sci U S A. 2008 Dec 09; 105(49):19372-7.Proc Natl Acad Sci U S A2008-12-02T00:00:002008Genomic alterations link Rho family of GTPases to the highly invasive phenotype of pancreas cancer.20478531Zheng H, Ying H, Wiedemeyer R, Yan H, Quayle SN, Ivanova EV, Paik JH, Zhang H, Xiao Y, Perry SR, Hu J, Vinjamoori A, Gan B, Sahin E, Chheda MG, Brennan C, Wang YA, Hahn WC, Chin L, DePinho RACancer cellPLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas. Cancer Cell. 2010 May 18; 17(5):497-509.Cancer Cell2010-05-18T00:00:002010PLAGL2 regulates Wnt signaling to impede differentiation in neural stem cells and gliomas.21113150Jaskelioff M, Muller FL, Paik JH, Thomas E, Jiang S, Adams AC, Sahin E, Kost-Alimova M, Protopopov A, Cadi?anos J, Horner JW, Maratos-Flier E, Depinho RANatureTelomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice. Nature. 2011 Jan 06; 469(7328):102-6.Nature2010-11-28T00:00:002010Telomerase reactivation reverses tissue degeneration in aged telomerase-deficient mice.21406549Yang S, Wang X, Contino G, Liesa M, Sahin E, Ying H, Bause A, Li Y, Stommel JM, Dell'antonio G, Mautner J, Tonon G, Haigis M, Shirihai OS, Doglioni C, Bardeesy N, Kimmelman ACGenes & developmentPancreatic cancers require autophagy for tumor growth. Genes Dev. 2011 Apr 01; 25(7):717-29.Genes Dev2011-03-15T00:00:002011Pancreatic cancers require autophagy for tumor growth.21788586Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, Zhu Z, Pimentel DR, Xu XJ, Ruderman NB, Huffman KD, Doctrow SR, Richey L, Colucci WS, Shirihai OSCirculationMitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011 Aug 16; 124(7):806-13.Circulation2011-07-25T00:00:002011Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion.22341440Hu J, Hwang SS, Liesa M, Gan B, Sahin E, Jaskelioff M, Ding Z, Ying H, Boutin AT, Zhang H, Johnson S, Ivanova E, Kost-Alimova M, Protopopov A, Wang YA, Shirihai OS, Chin L, DePinho RACellAntitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer. Cell. 2012 Feb 17; 148(4):651-63.Cell2012-02-17T00:00:002012Antitelomerase therapy provokes ALT and mitochondrial adaptive mechanisms in cancer.22588366Sahin E, DePinho RANature reviews. Molecular cell biologyAxis of ageing: telomeres, p53 and mitochondria. Nat Rev Mol Cell Biol. 2012 May 16; 13(6):397-404.Nat Rev Mol Cell Biol2012-05-16T00:00:002012Axis of ageing: telomeres, p53 and mitochondria.22895339Muller FL, Colla S, Aquilanti E, Manzo VE, Genovese G, Lee J, Eisenson D, Narurkar R, Deng P, Nezi L, Lee MA, Hu B, Hu J, Sahin E, Ong D, Fletcher-Sananikone E, Ho D, Kwong L, Brennan C, Wang YA, Chin L, DePinho RANaturePassenger deletions generate therapeutic vulnerabilities in cancer. Nature. 2012 Aug 16; 488(7411):337-42.Nature2012-08-16T00:00:002012Passenger deletions generate therapeutic vulnerabilities in cancer.Authorship 8683681728337975Lee CS, Hanna AD, Wang H, Dagnino-Acosta A, Joshi AD, Knoblauch M, Xia Y, Georgiou DK, Xu J, Long C, Amano H, Reynolds C, Dong K, Martin JC, Lagor WR, Rodney GG, Sahin E, Sewry C, Hamilton SLNature communicationsA chemical chaperone improves muscle function in mice with a RyR1 mutation. Nat Commun. 2017 03 24; 8:14659.Nat Commun2017-03-24T00:00:002017A chemical chaperone improves muscle function in mice with a RyR1 mutation.true1Assistant ProfessorAssistant Professortrue1ProfessorProfessorD008103Disorders2639370.591647Liver CirrhosisD008928AnatomyPhysiology57212860.585011MitochondriaD016615Anatomy2125080.762768TelomereD037761Chemicals & Drugs29440.96875SirtuinsAuthorship 9322431130498031Matsunuma R, Chan DW, Kim BJ, Singh P, Han A, Saltzman AB, Cheng C, Lei JT, Wang J, Roberto da Silva L, Sahin E, Leng M, Fan C, Perou CM, Malovannaya A, Ellis MJProceedings of the National Academy of Sciences of the United States of AmericaDPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer. Proc Natl Acad Sci U S A. 2018 12 18; 115(51):E11978-E11987.Proc Natl Acad Sci U S A2018-11-29T00:00:002018DPYSL3 modulates mitosis, migration, and epithelial-to-mesenchymal transition in claudin-low breast cancer.2021-03-31NIHSAHIN, ERGUN2015-04-01Role of Sirtuins in mediating telomere and p53-dependent aging and diseaseR01AG0479242019-05-31NIHSAHIN, ERGUN2016-06-01ESTABLISHING A CONDITIONAL TELOMERASE KNOCK-IN ALLELE IN A HAPLOID CANCER CELL LINE TO IDENTIFY REGULATORS OF ALT THROUGH GENETIC FORWARD SCREENSR21CA198701Principal InvestigatorPrincipal InvestigatorDepartment of MedicineDepartment of PediatricsDepartment of Molecular & Cellular BiologyHuffington Center on AgingHuffington Ctr on AgingMedicine-Gastroenterology & HepatolMolecular & Cellular BiologyMolecular Physiology & BiophysicsPediatrics-HematologyBaylor College of MedicineCHRISTINEBEETONCHRISTINE BEETON0.000000000000000.000000000000001233BEETON, CHRISTINEProfessorFRANKHORRIGANFRANK HORRIGAN0.000000000000000.000000000000001467HORRIGAN, FRANKAssociate ProfessorJOELNEILSONJOEL NEILSON0.000000000000000.000000000000001541NEILSON, JOELAssociate ProfessorALISONBERTUCHN6k183HSI4PVRIzgrn7GPw==ALISON BERTUCH0.000000000000000.000000000000002012BERTUCH, ALISONProfessor0.8619240.00418686166research areas1.002590.021614927coauthor of12.16742.2194960similar to1119selected publicationsAUDREYCHRISTIANSENAUDREY CHRISTIANSEN0.000000000000000.000000000000004678CHRISTIANSEN, AUDREYInstructorFASIHAKANWALFASIHA KANWAL29.70503200000000-95.407546000000004180KANWAL, FASIHAProfessorMARYDICKINSONMARY DICKINSON0.000000000000000.00000000000000831DICKINSON, MARYProfessorHASHEMEL-SERAGHASHEM EL-SERAG29.70560750000000-95.3846773000000068EL-SERAG, HASHEMProfessorIRINALARINAIRINA LARINA0.000000000000000.00000000000000875LARINA, IRINAProfessorAuthorship 9448851930930169Amano H, Chaudhury A, Rodriguez-Aguayo C, Lu L, Akhanov V, Catic A, Popov YV, Verdin E, Johnson H, Stossi F, Sinclair DA, Nakamaru-Ogiso E, Lopez-Berestein G, Chang JT, Neilson JR, Meeker A, Finegold M, Baur JA, Sahin ECell metabolismTelomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease. Cell Metab. 2019 06 04; 29(6):1274-1290.e9.Cell Metab2019-03-28T00:00:002019Telomere Dysfunction Induces Sirtuin Repression that Drives Telomere-Dependent Disease.D059506Physiology41570.937279Telomere ShorteningAuthorship 955633231528700Amano H, Sahin EMolecular & cellular oncologyTelomeres and sirtuins: at the end we meet again. Mol Cell Oncol. 2019; 6(5):e1632613.Mol Cell Oncol2019-07-07T00:00:002019Telomeres and sirtuins: at the end we meet again.true1ProfessorProfessorAuthorship 997383632811853Sweeney MA, Iakova P, Maneix L, Shih FY, Cho HE, Sahin E, Catic AScientific reportsThe ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes. Sci Rep. 2020 08 18; 10(1):13942.Sci Rep2020-08-18T00:00:002020The ubiquitin ligase Cullin-1 associates with chromatin and regulates transcription of specific c-MYC target genes.Authorship 1187519Authorship 1012851633671345Maneix L, Sweeney MA, Lee S, Iakova P, Moree SE, Sahin E, Lulla P, Yellapragada SV, Tsai FTF, Catic ACancersThe Mitochondrial Protease LonP1 Promotes Proteasome Inhibitor Resistance in Multiple Myeloma. Cancers (Basel). 2021 Feb 17; 13(4).Cancers (Basel)2021-02-17T00:00:002021The Mitochondrial Protease LonP1 Promotes Proteasome Inhibitor Resistance in Multiple Myeloma.Authorship 1028901734473704Freise C, Lee H, Chronowski C, Chan D, Cziomer J, R?hl M, Dagdelen T, L?sekann M, Erben U, Catic A, Tegge W, Schuppan D, Somasundaram R, Sahin EPloS oneAlpha-single chains of collagen type VI inhibit the fibrogenic effects of triple helical collagen VI in hepatic stellate cells. PLoS One. 2021; 16(9):e0254557.PLoS One2021-09-02T00:00:002021Alpha-single chains of collagen type VI inhibit the fibrogenic effects of triple helical collagen VI in hepatic stellate cells.Authorship 10333631934824242Thongon N, Ma F, Santoni A, Marchesini M, Fiorini E, Rose A, Adema V, Ganan-Gomez I, Groarke EM, Gutierrez-Rodrigues F, Chen S, Lockyer P, Schneider S, Bueso-Ramos C, Montalban-Bravo G, Class CA, Soltysiak KA, Pellegrini M, Sahin E, Bertuch AA, DiNardo CD, Garcia-Manero G, Young NS, Dwyer K, Colla SNature communicationsHematopoiesis under telomere attrition at the single-cell resolution. Nat Commun. 2021 11 25; 12(1):6850.Nat Commun2021-11-25T00:00:002021Hematopoiesis under telomere attrition at the single-cell resolution.Authorship 1039898535159073Moree SE, Maneix L, Iakova P, Stossi F, Sahin E, Catic ACancersImaging-Based Screening of Deubiquitinating Proteases Identifies Otubain-1 as a Stabilizer of c-MYC. Cancers (Basel). 2022 Feb 04; 14(3).Cancers (Basel)2022-02-04T00:00:002022Imaging-Based Screening of Deubiquitinating Proteases Identifies Otubain-1 as a Stabilizer of c-MYC.true1ProfessorProfessortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professortrue1Associate ProfessorAssociate Professor2Associate ProfessorAssociate Professortrue1InstructorInstructorDepartment of Integrative Physiologytrue1ProfessorProfessorAuthorship 1064672936846090Maneix L, Iakova P, Moree SE, Hsu JI, Mistry RM, Stossi F, Lulla P, Sun Z, Sahin E, Yellapragada SV, Catic ACancer research communicationsProteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 (HDAC3) Stabilization and Chromatin Condensation. Cancer Res Commun. 2022 12; 2(12):1693-1710.Cancer Res Commun2022-12-27T00:00:002022Proteasome Inhibitors Silence Oncogenes in Multiple Myeloma through Localized Histone Deacetylase 3 (HDAC3) Stabilization and Chromatin Condensation.true1ProfessorProfessortrue1Assistant ProfessorAssistant Professortrue1Assistant ProfessorAssistant Professortrue1ProfessorProfessortrue1ProfessorProfessorAuthorship 495112ANDRECATICANDRE CATIC7353CATIC, ANDREAssistant ProfessorAuthorship 6436314Authorship 7166314Authorship 988187