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TSZ-KWONG MAN

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1102 BATES
Houston, TX 77030
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    Collapse Overview 

    Collapse Research 
    Collapse research activities and funding
    3R33HD105593     (ANNAPRAGADA, ANANTH V)Jan 1, 2023 - Nov 30, 2024
    NICHD
    AICORE-kids: Artificial Intelligence COVID-19 Risk AssEssment for kids
    Role: Co-Investigator
    RP200135     (MAN, TSZ-KWONG)Aug 31, 2020 - Aug 30, 2024
    Cancer Prevention and Research Institute of Texas
    Targeting the CXCL10-CXCR3 Axis in Metastatic Osteosarcoma
    Role: Principal Investigator
    U01CA217613     (LI, XIAONAN)Mar 3, 2020 - Feb 28, 2025
    NIH
    Matching panels of in vivo and in vitro model system of pediatric brain tumors
    Role: Co-Investigator
    R01HD074553     (MAN, TSZ-KWONG)Jan 1, 2013 - Dec 31, 2017
    NIH
    Harnessing p27 for Prognostication of Pediatric Osteosarcoma
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Cobos FA, Panah MJN, Epps J, Long X, Man TK, Chiu HS, Chomsky E, Kiner E, Krueger MJ, di Bernardo D, Voloch L, Molenaar J, van Hooff SR, Westermann F, Jansky S, Redell ML, Mestdagh P, Sumazin P. Effective methods for bulk RNA-seq deconvolution using scnRNA-seq transcriptomes. Genome Biol. 2023 08 01; 24(1):177. PMID: 37528411; PMCID: PMC10394903.
      Citations: 3     Fields:    Translation:HumansCells
    2. Sun JM, Chow WY, Xu G, Hicks MJ, Nakka M, Shen J, Ng PKS, Taylor AM, Yu A, Farrar JE, Barkauskas DA, Gorlick R, Guidry Auvil JM, Gerhard D, Meltzer P, Guerra R, Man TK, Lau CC. The Role of FAS Receptor Methylation in Osteosarcoma Metastasis. Int J Mol Sci. 2023 Jul 29; 24(15). PMID: 37569529; PMCID: PMC10418590.
      Citations:    Fields:    Translation:AnimalsCells
    3. Geerlinks AV, Scull B, Krupski C, Fleischmann R, Pulsipher MA, Eapen M, Connelly JA, Bollard CM, Pai SY, Duncan CN, Kean LS, Baker KS, Burroughs LM, Andolina JR, Shenoy S, Roehrs P, Hanna R, Talano JA, Schultz KR, Stenger EO, Lin H, Zoref-Lorenz A, McClain KL, Jordan MB, Man TK, Allen CE, Marsh RA. Alemtuzumab and CXCL9 levels predict likelihood of sustained engraftment after reduced-intensity conditioning HCT. Blood Adv. 2023 07 25; 7(14):3725-3734. PMID: 37042921; PMCID: PMC10368780.
      Citations:    Fields:    Translation:Humans
    4. Zhao S, Li J, Zhang H, Qi L, Du Y, Kogiso M, Braun FK, Xiao S, Huang Y, Li J, Teo WY, Lindsay H, Baxter P, Su JMF, Adesina A, Laczik M, Genevini P, Veillard AC, Schvartzman S, Berguet G, Ding SR, Du L, Stephan C, Yang J, Davies PJA, Lu X, Chintagumpala M, Parsons DW, Perlaky L, Xia YF, Man TK, Huang Y, Sun D, Li XN. Publisher Correction: Epigenetic alterations of repeated relapses in patient-matched childhood ependymomas. Nat Commun. 2022 Dec 22; 13(1):7871. PMID: 36550163.
      Citations:    Fields:    
    5. Tsang SV, Rainusso N, Liu M, Nomura M, Patel TD, Nakahata K, Kim HR, Huang S, Rajapakshe K, Coarfa C, Man TK, Rao PH, Yustein JT. LncRNA PVT-1 promotes osteosarcoma cancer stem-like properties through direct interaction with TRIM28 and TSC2 ubiquitination. Oncogene. 2022 Nov 08. PMID: 36348010.
      Citations: 3     Fields:    
    6. Zhao S, Li J, Zhang H, Qi L, Du Y, Kogiso M, Braun FK, Xiao S, Huang Y, Li J, Teo WY, Lindsay H, Baxter P, Su JMF, Adesina A, Laczik M, Genevini P, Veillard AC, Schvartzman S, Berguet G, Ding SR, Du L, Stephan C, Yang J, Davies PJA, Lu X, Chintagumpala M, Parsons DW, Perlaky L, Xia YF, Man TK, Huang Y, Li XN, Sun D. Epigenetic Alterations of Repeated Relapses in Patient-matched Childhood Ependymomas. Nat Commun. 2022 11 05; 13(1):6689. PMID: 36335125; PMCID: PMC9637194.
      Citations: 4     Fields:    Translation:HumansCells
    7. Taylor AM, Sun JM, Yu A, Voicu H, Shen J, Barkauskas DA, Triche TJ, Gastier-Foster JM, Man TK, Lau CC. Integrated DNA Copy Number and Expression Profiling Identifies IGF1R as a Prognostic Biomarker in Pediatric Osteosarcoma. Int J Mol Sci. 2022 Jul 21; 23(14). PMID: 35887382; PMCID: PMC9319262.
      Citations:    Fields:    Translation:Humans
    8. Chen X, Clement M, Hicks MJ, Sarkar P, Gaber MW, Man TK. LOX upregulates FAK phosphorylation to promote metastasis in osteosarcoma. Genes Dis. 2023 Jan; 10(1):254-266. PMID: 37013056; PMCID: PMC10066266.
      Citations:    
    9. Man TK, Aubert G, Richard MA, LeJeune W, Hariri E, Goltsova T, Gaikwad A, Chen Y, Whitton J, Leisenring WM, Arnold MA, Neglia JP, Yasui Y, Robison LL, Armstrong GT, Bhatia S, Gramatges MM. Short NK- and Na?ve T-Cell Telomere Length Is Associated with Thyroid Cancer in Childhood Cancer Survivors: A Report from the Childhood Cancer Survivor Study. Cancer Epidemiol Biomarkers Prev. 2022 02; 31(2):453-460. PMID: 34782395; PMCID: PMC8825729.
      Citations:    Fields:    Translation:HumansCells
    10. Huang Y, Qi L, Kogiso M, Du Y, Braun FK, Zhang H, Huang LF, Xiao S, Teo WY, Lindsay H, Zhao S, Baxter P, Su JMF, Adesina A, Yang J, Brabetz S, Kool M, Pfister SM, Chintagumpala M, Perlaky L, Wang Z, Zhou Y, Man TK, Li XN. Spatial Dissection of Invasive Front from Tumor Mass Enables Discovery of Novel microRNA Drivers of Glioblastoma Invasion. Adv Sci (Weinh). 2021 12; 8(23):e2101923. PMID: 34719887; PMCID: PMC8655179.
      Citations: 1     Fields:    Translation:HumansAnimalsCells
    11. Lin H, Scull BP, Goldberg BR, Abhyankar HA, Eckstein OE, Zinn DJ, Lubega J, Agrusa J, El Mallawaney N, Gulati N, Forbes L, Chinn I, Chakraborty R, Velasquez J, Goldman J, Bashir D, Lam F, Muscal E, Henry MM, Greenberg JN, Ladisch S, Hermiston ML, Meyer LK, Jeng M, Naqvi A, McClain K, Nguyen T, Wong H, Man TK, Jordan MB, Allen CE. IFN-? signature in the plasma proteome distinguishes pediatric hemophagocytic lymphohistiocytosis from sepsis and SIRS. Blood Adv. 2021 09 14; 5(17):3457-3467. PMID: 34461635; PMCID: PMC8525230.
      Citations: 4     Fields:    Translation:Humans
    12. Narayanan P, Man TK, Gerbing RB, Ries R, Stevens AM, Wang YC, Long X, Gamis AS, Cooper T, Meshinchi S, Alonzo TA, Redell MS. Aberrantly low STAT3 and STAT5 responses are associated with poor outcome and an inflammatory gene expression signature in pediatric acute myeloid leukemia. Clin Transl Oncol. 2021 Oct; 23(10):2141-2154. PMID: 33948920; PMCID: PMC8390401.
      Citations:    Fields:    Translation:HumansCells
    13. Agrusa JE, Scull BP, Abhyankar HA, Lin H, Ozuah NW, Chakraborty R, Eckstein OS, Gulati N, Fattah EA, El-Mallawany NK, Rouce RH, Dreyer ZE, Brackett J, Margolin JF, Lubega J, Horton TM, Bollard CM, Gramatges MM, Kamdar KY, McClain KL, Man TK, Allen CE. Defining the Inflammatory Plasma Proteome in Pediatric Hodgkin Lymphoma. Cancers (Basel). 2020 Dec 02; 12(12). PMID: 33276546; PMCID: PMC7761312.
      Citations: 1     
    14. Qi L, Kogiso M, Du Y, Zhang H, Braun FK, Huang Y, Teo WY, Lindsay H, Zhao S, Baxter P, Zhao X, Yu L, Liu Z, Zhang X, Su JM, Adesina A, Yang J, Chintagumpala M, Perlaky L, Tsz-Kwong Man C, Lau CC, Li XN. Impact of SCID mouse gender on tumorigenicity, xenograft growth and drug-response in a large panel of orthotopic PDX models of pediatric brain tumors. Cancer Lett. 2020 11 28; 493:197-206. PMID: 32891713; PMCID: PMC10306089.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    15. Chen X, Cates JMM, Du YC, Jain A, Jung SY, Li XN, Hicks JM, Man TK. Mislocalized cytoplasmic p27 activates PAK1-mediated metastasis and is a prognostic factor in osteosarcoma. Mol Oncol. 2020 04; 14(4):846-864. PMID: 31872963; PMCID: PMC7138393.
      Citations: 5     Fields:    Translation:HumansAnimalsCells
    16. Lim KPH, Milne P, Poidinger M, Duan K, Lin H, McGovern N, Abhyankar H, Zinn D, Burke TM, Eckstein OS, Chakraborty R, Sengal A, Scull B, Newell E, Merad M, McClain KL, Man TK, Ginhoux F, Collin M, Allen CE. Circulating CD1c+ myeloid dendritic cells are potential precursors to LCH lesion CD1a+CD207+ cells. Blood Adv. 2020 01 14; 4(1):87-99. PMID: 31899802; PMCID: PMC6960472.
      Citations: 3     Fields:    Translation:HumansCells
    17. Eckstein OS, Visser J, Rodriguez-Galindo C, Allen CE, NACHO-LIBRE Study Group. Clinical responses and persistent BRAF V600E+ blood cells in children with LCH treated with MAPK pathway inhibition. Blood. 2019 04 11; 133(15):1691-1694. PMID: 30718231; PMCID: PMC6460419.
      Citations: 19     Fields:    Translation:HumansCells
    18. Huang L, Garrett Injac S, Cui K, Braun F, Lin Q, Du Y, Zhang H, Kogiso M, Lindsay H, Zhao S, Baxter P, Adekunle A, Man TK, Zhao H, Li XN, Lau CC, Wong STC. Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma. Sci Transl Med. 2018 10 24; 10(464). PMID: 30355798; PMCID: PMC6644046.
      Citations: 21     Fields:    Translation:AnimalsCells
    19. McClain KL, Picarsic J, Chakraborty R, Zinn D, Lin H, Abhyankar H, Scull B, Shih A, Lim KPH, Eckstein O, Lubega J, Peters TL, Olea W, Burke T, Ahmed N, Hicks MJ, Tran B, Jones J, Dauser R, Jeng M, Baiocchi R, Schiff D, Goldman S, Heym KM, Wilson H, Carcamo B, Kumar A, Rodriguez-Galindo C, Whipple NS, Campbell P, Murdoch G, Kofler J, Heales S, Malone M, Woltjer R, Quinn JF, Orchard P, Kruer MC, Jaffe R, Manz MG, Lira SA, Parsons DW, Merad M, Man TK, Allen CE. CNS Langerhans cell histiocytosis: Common hematopoietic origin for LCH-associated neurodegeneration and mass lesions. Cancer. 2018 06 15; 124(12):2607-2620. PMID: 29624648; PMCID: PMC6289302.
      Citations: 18     Fields:    Translation:HumansCells
    20. Bielamowicz K, Fousek K, Byrd TT, Samaha H, Mukherjee M, Aware N, Wu MF, Orange JS, Sumazin P, Man TK, Joseph SK, Hegde M, Ahmed N. Trivalent CAR T cells overcome interpatient antigenic variability in glioblastoma. Neuro Oncol. 2018 03 27; 20(4):506-518. PMID: 29016929; PMCID: PMC5909636.
      Citations: 153     Fields:    Translation:HumansAnimalsCells
    21. Hogstad B, Berres ML, Chakraborty R, Tang J, Bigenwald C, Serasinghe M, Lim KPH, Lin H, Man TK, Remark R, Baxter S, Kana V, Jordan S, Karoulia Z, Kwan WH, Leboeuf M, Brandt E, Salmon H, McClain K, Poulikakos P, Chipuk J, Mulder WJM, Allen CE, Merad M. RAF/MEK/extracellular signal-related kinase pathway suppresses dendritic cell migration and traps dendritic cells in Langerhans cell histiocytosis lesions. J Exp Med. 2018 01 02; 215(1):319-336. PMID: 29263218; PMCID: PMC5748846.
      Citations: 21     Fields:    Translation:HumansAnimalsCells
    22. Flores, RJ, Kelly AJ, Nakka M, Chen X, Sun J, MAN TK. The advancements of genomics and data integration in sarcoma research. Advances in Modern Oncology Research. 2017; 3(4):177-93. View Publication.
    23. Glover J, Man TK, Barkauskas DA, Hall D, Tello T, Sullivan MB, Gorlick R, Janeway K, Grier H, Lau C, Toretsky JA, Borinstein SC, Khanna C, Fan TM, COG Osteosarcoma Biology Group. Osteosarcoma enters a post genomic era with in silico opportunities: Generation of the High Dimensional Database for facilitating sarcoma biology research: A report from the Children's Oncology Group and the QuadW Foundation. PLoS One. 2017; 12(7):e0181204. PMID: 28732082; PMCID: PMC5521774.
      Citations: 5     Fields:    Translation:Humans
    24. Nakka M, Allen-Rhoades W, Li Y, Kelly AJ, Shen J, Taylor AM, Barkauskas DA, Yustein JT, Andrulis IL, Wunder JS, Gorlick R, Meltzer PS, Lau CC, Man TK, TARGET osteosarcoma consortium. Biomarker significance of plasma and tumor miR-21, miR-221, and miR-106a in osteosarcoma. Oncotarget. 2017 Nov 14; 8(57):96738-96752. PMID: 29228567; PMCID: PMC5722519.
      Citations: 18     Fields:    
    25. Flores RJ, Kelly AJ, Li Y, Chen X, McGee C, Krailo M, Barkauskas DA, Hicks J, Man TK. The prognostic significance of circulating serum amyloid A and CXC chemokine ligand 4 in osteosarcoma. Pediatr Blood Cancer. 2017 Dec; 64(12). PMID: 28544777; PMCID: PMC5695860.
      Citations:    Fields:    Translation:Humans
    26. Flores RJ, Kelly AJ, Li Y, Nakka M, Barkauskas DA, Krailo M, Wang LL, Perlaky L, Lau CC, Hicks MJ, Man TK. A novel prognostic model for osteosarcoma using circulating CXCL10 and FLT3LG. Cancer. 2017 Jan 01; 123(1):144-154. PMID: 27529817; PMCID: PMC5161556.
      Citations: 15     Fields:    Translation:Humans
    27. Davis CF, Ritter DI, Wheeler DA, Wang H, Ding Y, Dugan SP, Bainbridge MN, Muzny DM, Rao PH, Man TK, Plon SE, Gibbs RA, Lau CC. SV-STAT accurately detects structural variation via alignment to reference-based assemblies. Source Code Biol Med. 2016; 11:8. PMID: 27330550; PMCID: PMC4913042.
      Citations: 3     
    28. Li Y, Nakka M, Kelly AJ, Lau CC, Krailo M, Barkauskas DA, Hicks JM, Man TK. p27 Is a Candidate Prognostic Biomarker and Metastatic Promoter in Osteosarcoma. Cancer Res. 2016 07 01; 76(13):4002-11. PMID: 27197201; PMCID: PMC4930684.
      Citations: 16     Fields:    Translation:HumansAnimalsCells
    29. Rao PH, Zhao S, Zhao YJ, Yu A, Rainusso N, Trucco M, Allen-Rhoades W, Satterfield L, Fuja D, Borra VJ, Man TK, Donehower LA, Yustein JT. Coamplification of Myc/Pvt1 and homozygous deletion of Nlrp1 locus are frequent genetics changes in mouse osteosarcoma. Genes Chromosomes Cancer. 2015 Dec; 54(12):796-808. PMID: 26355645.
      Citations: 10     Fields:    Translation:AnimalsCells
    30. Long X, Yu Y, Perlaky L, Man TK, Redell MS. Stromal CYR61 Confers Resistance to Mitoxantrone via Spleen Tyrosine Kinase Activation in Human Acute Myeloid Leukaemia. Br J Haematol. 2015 Sep; 170(5):704-18. PMID: 25974135; PMCID: PMC5490799.
      Citations: 18     Fields:    Translation:HumansCellsCTClinical Trials
    31. Zhao S, Kurenbekova L, Gao Y, Roos A, Creighton CJ, Rao P, Hicks J, Man TK, Lau C, Brown AM, Jones SN, Lazar AJ, Ingram D, Lev D, Donehower LA, Yustein JT. NKD2, a negative regulator of Wnt signaling, suppresses tumor growth and metastasis in osteosarcoma. Oncogene. 2015 Sep 24; 34(39):5069-79. PMID: 25579177; PMCID: PMC4802362.
      Citations: 57     Fields:    Translation:AnimalsCells
    32. Baxter PA, Lin Q, Mao H, Kogiso M, Zhao X, Liu Z, Huang Y, Voicu H, Gurusiddappa S, Su JM, Adesina AM, Perlaky L, Dauser RC, Leung HC, Muraszko KM, Heth JA, Fan X, Lau CC, Man TK, Chintagumpala M, Li XN. Silencing BMI1 eliminates tumor formation of pediatric glioma CD133+ cells not by affecting known targets but by down-regulating a novel set of core genes. Acta Neuropathol Commun. 2014 Dec 20; 2:160. PMID: 25526772; PMCID: PMC4289398.
      Citations: 12     Fields:    Translation:HumansAnimalsCells
    33. Teo WY, Elghetany MT, Shen J, Man TK, Li X, Chintagumpala M, Su JM, Dauser R, Whitehead W, Adesina AM, Lau CC. Therapeutic implications of CD1d expression and tumor-infiltrating macrophages in pediatric medulloblastomas. J Neurooncol. 2014 Nov; 120(2):293-301. PMID: 25115738.
      Citations: 8     Fields:    Translation:HumansAnimalsCells
    34. Liu Z, Zhao X, Wang Y, Mao H, Huang Y, Kogiso M, Qi L, Baxter PA, Man TK, Adesina A, Su JM, Picard D, Ching Ho K, Huang A, Perlaky L, Lau CC, Chintagumpala M, Li XN. A patient tumor-derived orthotopic xenograft mouse model replicating the group 3 supratentorial primitive neuroectodermal tumor in children. Neuro Oncol. 2014 Jun; 16(6):787-99. PMID: 24470556; PMCID: PMC4022216.
      Citations: 7     Fields:    Translation:HumansAnimals
    35. Terashima K, Yu A, Chow WY, Hsu WC, Chen P, Wong S, Hung YS, Suzuki T, Nishikawa R, Matsutani M, Nakamura H, Ng HK, Allen JC, Aldape KD, Su JM, Adesina AM, Leung HC, Man TK, Lau CC. Genome-wide analysis of DNA copy number alterations and loss of heterozygosity in intracranial germ cell tumors. Pediatr Blood Cancer. 2014 Apr; 61(4):593-600. PMID: 24249158.
      Citations: 16     Fields:    Translation:Humans
    36. Barbieri E, De Preter K, Capasso M, Johansson P, Man TK, Chen Z, Stowers P, Tonini GP, Speleman F, Shohet JM. A p53 drug response signature identifies prognostic genes in high-risk neuroblastoma. PLoS One. 2013; 8(11):e79843. PMID: 24348903; PMCID: PMC3865347.
      Citations: 18     Fields:    Translation:HumansCells
    37. Chen P, Fan Y, Man TK, Hung YS, Lau CC, Wong ST. A gene signature based method for identifying subtypes and subtype-specific drivers in cancer with an application to medulloblastoma. BMC Bioinformatics. 2013; 14 Suppl 18:S1. PMID: 24564171; PMCID: PMC3820164.
      Citations: 10     Fields:    Translation:Humans
    38. Teo WY, Shen J, Su JM, Yu A, Wang J, Chow WY, Li X, Jones J, Dauser R, Whitehead W, Adesina AM, Chintagumpala M, Man TK, Lau CC. Implications of tumor location on subtypes of medulloblastoma. Pediatr Blood Cancer. 2013 Sep; 60(9):1408-10. PMID: 23512859.
      Citations: 25     Fields:    Translation:HumansCTClinical Trials
    39. Flores RJ, Li Y, Yu A, Shen J, Rao PH, Lau SS, Vannucci M, Lau CC, Man TK. A systems biology approach reveals common metastatic pathways in osteosarcoma. BMC Syst Biol. 2012 May 28; 6:50. PMID: 22640921; PMCID: PMC3431263.
      Citations: 28     Fields:    Translation:HumansAnimalsCells
    40. Li Y, Dang TA, Man TK. Plasma proteomic profiling of pediatric osteosarcoma. Methods Mol Biol. 2012; 818:81-96. PMID: 22083817.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    41. Egler RA, Li Y, Dang TA, Peters TL, Leung E, Huang S, Russell HV, Liu H, Man TK. An integrated proteomic approach to identifying circulating biomarkers in high-risk neuroblastoma and their potential in relapse monitoring. Proteomics Clin Appl. 2011 Oct; 5(9-10):532-41. PMID: 21833997; PMCID: PMC3685293.
      Citations: 7     Fields:    Translation:Humans
    42. Rainusso N, Man TK, Lau CC, Hicks J, Shen JJ, Yu A, Wang LL, Rosen JM. Identification and gene expression profiling of tumor-initiating cells isolated from human osteosarcoma cell lines in an orthotopic mouse model. Cancer Biol Ther. 2011 Aug 15; 12(4):278-87. PMID: 21617384; PMCID: PMC3173730.
      Citations: 13     Fields:    Translation:HumansAnimalsCells
    43. Daves MH, Hilsenbeck SG, Lau CC, Man TK. Meta-analysis of multiple microarray datasets reveals a common gene signature of metastasis in solid tumors. BMC Med Genomics. 2011 Jul 07; 4:56. PMID: 21736749; PMCID: PMC3212952.
      Citations: 29     Fields:    Translation:Humans
    44. Guo B, Villagran A, Vannucci M, Wang J, Davis C, Man TK, Lau C, Guerra R. Bayesian estimation of genomic copy number with single nucleotide polymorphism genotyping arrays. BMC Res Notes. 2010 Dec 30; 3:350. PMID: 21192799; PMCID: PMC3023756.
      Citations:    Fields:    
    45. Li Y, Dang TA, Shen J, Hicks J, Chintagumpala M, Lau CC, Man TK. Plasma proteome predicts chemotherapy response in osteosarcoma patients. Oncol Rep. 2011 Feb; 25(2):303-14. PMID: 21165584.
      Citations: 11     Fields:    Translation:Humans
    46. Li Y, Flores R, Yu A, Okcu MF, Murray J, Chintagumpala M, Hicks J, Lau CC, Man TK. Elevated expression of CXC chemokines in pediatric osteosarcoma patients. Cancer. 2011 Jan 01; 117(1):207-17. PMID: 20806347; PMCID: PMC2997117.
      Citations: 13     Fields:    Translation:HumansCells
    47. Allen CE, Li L, Peters TL, Leung HC, Yu A, Man TK, Gurusiddappa S, Phillips MT, Hicks MJ, Gaikwad A, Merad M, McClain KL. Cell-specific gene expression in Langerhans cell histiocytosis lesions reveals a distinct profile compared with epidermal Langerhans cells. J Immunol. 2010 Apr 15; 184(8):4557-67. PMID: 20220088; PMCID: PMC3142675.
      Citations: 98     Fields:    Translation:HumansCells
    48. Yu L, Baxter PA, Voicu H, Gurusiddappa S, Zhao Y, Adesina A, Man TK, Shu Q, Zhang YJ, Zhao XM, Su JM, Perlaky L, Dauser R, Chintagumpala M, Lau CC, Blaney SM, Rao PH, Leung HC, Li XN. A clinically relevant orthotopic xenograft model of ependymoma that maintains the genomic signature of the primary tumor and preserves cancer stem cells in vivo. Neuro Oncol. 2010 Jun; 12(6):580-94. PMID: 20511191; PMCID: PMC2940646.
      Citations: 52     Fields:    Translation:HumansAnimalsCells
    49. Ma O, Cai WW, Zender L, Dayaram T, Shen J, Herron AJ, Lowe SW, Man TK, Lau CC, Donehower LA. MMP13, Birc2 (cIAP1), and Birc3 (cIAP2), amplified on chromosome 9, collaborate with p53 deficiency in mouse osteosarcoma progression. Cancer Res. 2009 Mar 15; 69(6):2559-67. PMID: 19276372; PMCID: PMC2663905.
      Citations: 54     Fields:    Translation:HumansAnimalsCells
    50. Cruz-Marcelo A, Guerra R, Vannucci M, Li Y, Lau CC, Man TK. Comparison of algorithms for pre-processing of SELDI-TOF mass spectrometry data. Bioinformatics. 2008 Oct 01; 24(19):2129-36. PMID: 18694894; PMCID: PMC2553436.
      Citations: 14     Fields:    Translation:Humans
    51. Rabin KR, Man TK, Yu A, Folsom MR, Zhao YJ, Rao PH, Plon SE, Naeem RC. Clinical utility of array comparative genomic hybridization for detection of chromosomal abnormalities in pediatric acute lymphoblastic leukemia. Pediatr Blood Cancer. 2008 Aug; 51(2):171-7. PMID: 18253961; PMCID: PMC4063297.
      Citations: 8     Fields:    Translation:HumansCells
    52. Rabin K, Man TK, Lau CC. Personalized care of pediatric cancer patients. Nestle Nutr Workshop Ser Pediatr Program. 2008; 62:173-85; discussion 185-8. PMID: 18626200.
      Citations: 2     Fields:    Translation:Humans
    53. Gu JX, Wei MY, Rao PH, Lau CC, Behl S, Man TK. CGI: Java software for mapping and visualizing data from array-based comparative genomic hybridization and expression profiling. Gene Regul Syst Bio. 2007 Oct 06; 1:131-6. PMID: 19936083; PMCID: PMC2759124.
      Citations: 1     
    54. De Bortoli M, Castellino RC, Skapura DG, Shen JJ, Su JM, Russell HV, Hicks MJ, Man TK, Kim JY. Patched haploinsufficient mouse rhabdomyosarcoma overexpress secreted phosphoprotein 1 and matrix metalloproteinases. Eur J Cancer. 2007 May; 43(8):1308-17. PMID: 17467979.
      Citations: 3     Fields:    Translation:HumansAnimals
    55. Dang TA, Man TK. Classification of sarcomas using bioinformatics and molecular profiling. Curr Pharm Biotechnol. 2007 Apr; 8(2):83-91. PMID: 17430156.
      Citations: 1     Fields:    Translation:Humans
    56. De Bortoli M, Castellino RC, Lu XY, Deyo J, Sturla LM, Adesina AM, Perlaky L, Pomeroy SL, Lau CC, Man TK, Rao PH, Kim JY. Medulloblastoma outcome is adversely associated with overexpression of EEF1D, RPL30, and RPS20 on the long arm of chromosome 8. BMC Cancer. 2006 Sep 12; 6:223. PMID: 16968546; PMCID: PMC1578584.
      Citations: 28     Fields:    Translation:HumansCells
    57. Li Y, Dang TA, Shen J, Perlaky L, Hicks J, Murray J, Meyer W, Chintagumpala M, Lau CC, Man TK. Identification of a plasma proteomic signature to distinguish pediatric osteosarcoma from benign osteochondroma. Proteomics. 2006 Jun; 6(11):3426-35. PMID: 16673437.
      Citations: 20     Fields:    Translation:Humans
    58. Man TK, Li Y, Dang TA, Shen J, Perlaky L, Lau CC. Optimising the use of TRIzol-extracted proteins in surface enhanced laser desorption/ ionization (SELDI) analysis. Proteome Sci. 2006 Mar 23; 4:3. PMID: 16556310; PMCID: PMC1440846.
      Citations: 10     
    59. Man TK, Chintagumpala M, Visvanathan J, Shen J, Perlaky L, Hicks J, Johnson M, Davino N, Murray J, Helman L, Meyer W, Triche T, Wong KK, Lau CC. Expression profiles of osteosarcoma that can predict response to chemotherapy. Cancer Res. 2005 Sep 15; 65(18):8142-50. PMID: 16166288.
      Citations: 50     Fields:    Translation:Humans
    60. Man TK, Lu XY, Jaeweon K, Perlaky L, Harris CP, Shah S, Ladanyi M, Gorlick R, Lau CC, Rao PH. Genome-wide array comparative genomic hybridization analysis reveals distinct amplifications in osteosarcoma. BMC Cancer. 2004 Aug 07; 4:45. PMID: 15298715; PMCID: PMC514550.
      Citations: 64     Fields:    Translation:HumansCells
    61. Man TK, Yang JS, Stormo GD. Quantitative modeling of DNA-protein interactions: effects of amino acid substitutions on binding specificity of the Mnt repressor. Nucleic Acids Res. 2004; 32(13):4026-32. PMID: 15289576; PMCID: PMC506813.
      Citations: 12     Fields:    Translation:Cells
    62. Wong KK, Tsang YT, Shen J, Cheng RS, Chang YM, Man TK, Lau CC. Allelic imbalance analysis by high-density single-nucleotide polymorphic allele (SNP) array with whole genome amplified DNA. Nucleic Acids Res. 2004 May 17; 32(9):e69. PMID: 15148342; PMCID: PMC419627.
      Citations: 28     Fields:    Translation:HumansCells
    63. Man TK, Stormo GD. Non-independence of Mnt repressor-operator interaction determined by a new quantitative multiple fluorescence relative affinity (QuMFRA) assay. Nucleic Acids Res. 2001 Jun 15; 29(12):2471-8. PMID: 11410653; PMCID: PMC55749.
      Citations: 92     Fields:    Translation:Cells
    64. Harris ZL, Durley AP, Man TK, Gitlin JD. Targeted gene disruption reveals an essential role for ceruloplasmin in cellular iron efflux. Proc Natl Acad Sci U S A. 1999 Sep 14; 96(19):10812-7. PMID: 10485908; PMCID: PMC17965.
      Citations: 165     Fields:    Translation:Animals
    65. Yang Y, Zhao G, Man TK, Winkler ME. Involvement of the gapA- and epd (gapB)-encoded dehydrogenases in pyridoxal 5'-phosphate coenzyme biosynthesis in Escherichia coli K-12. J Bacteriol. 1998 Aug; 180(16):4294-9. PMID: 9696782; PMCID: PMC107430.
      Citations: 13     Fields:    Translation:Cells
    66. Yang Y, Tsui HC, Man TK, Winkler ME. Identification and function of the pdxY gene, which encodes a novel pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate biosynthesis in Escherichia coli K-12. J Bacteriol. 1998 Apr; 180(7):1814-21. PMID: 9537380; PMCID: PMC107095.
      Citations: 31     Fields:    Translation:Cells
    67. Man TK, Pease AJ, Winkler ME. Maximization of transcription of the serC (pdxF)-aroA multifunctional operon by antagonistic effects of the cyclic AMP (cAMP) receptor protein-cAMP complex and Lrp global regulators of Escherichia coli K-12. J Bacteriol. 1997 Jun; 179(11):3458-69. PMID: 9171388; PMCID: PMC179136.
      Citations: 8     Fields:    Translation:Cells
    68. Man TK, Zhao G, Winkler ME. Isolation of a pdxJ point mutation that bypasses the requirement for the PdxH oxidase in pyridoxal 5' -phosphate coenzyme biosynthesis in Escherichia coli K-12. J Bacteriol. 1996 Apr; 178(8):2445-9. PMID: 8636054; PMCID: PMC177961.
      Citations: 4     Fields:    Translation:Cells
    69. Cheung AN, Srivastava G, Chung LP, Ngan HY, Man TK, Liu YT, Chen WZ, Collins RJ, Wong LC, Ma HK. Expression of the p53 gene in trophoblastic cells in hydatidiform moles and normal human placentas. J Reprod Med. 1994 Mar; 39(3):223-7. PMID: 8035377.
      Citations: 7     Fields:    Translation:HumansCells
    70. Cheung AN, Srivastava G, Pittaluga S, Man TK, Ngan H, Collins RJ. Expression of c-myc and c-fms oncogenes in trophoblastic cells in hydatidiform mole and normal human placenta. J Clin Pathol. 1993 Mar; 46(3):204-7. PMID: 8463412; PMCID: PMC501170.
      Citations: 6     Fields:    Translation:HumansCells
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