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DARRYL HADSELL

TitleAssociate Professor
InstitutionBaylor College of Medicine
DepartmentDepartment of Pediatrics
Address1100 Bates Street
Houston, 77030
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    Collapse Research 
    Collapse research activities and funding
    R21HD094238     (HADSELL, DARRYL L)Jul 1, 2018 - Jun 30, 2021
    NIH
    The Microbiome in Mammary Development, and Lacatation
    Role: Principal Investigator
    R21HD056439     (HADSELL, DARRYL L)Mar 3, 2010 - Feb 28, 2013
    NIH
    Maternal obesity and mammary cell mitochondrial function during lactation
    Role: Principal Investigator
    R21HD059746     (HADSELL, DARRYL L)Apr 10, 2009 - Feb 28, 2012
    NIH
    QTL and QTL Genes Underlying Lactation Performance
    Role: Principal Investigator
    R01DK052197     (HADSELL, DARRYL L)Jan 24, 1997 - Feb 28, 2008
    NIH
    IGF-1 Receptor Signaling in Mammary Gland Development
    Role: Principal Investigator
    F32HD007618     (HADSELL, DARRYL L)Feb 21, 1993
    NIH
    TARGETING OF IGF-I EXPRESSION TO THE MAMMARY GLAND
    Role: Principal Investigator

    Collapse Bibliographic 
    Collapse selected publications
    Publications listed below are automatically derived from MEDLINE/PubMed and other sources, which might result in incorrect or missing publications. Faculty can login to make corrections and additions.
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    PMC Citations indicate the number of times the publication was cited by articles in PubMed Central, and the Altmetric score represents citations in news articles and social media. (Note that publications are often cited in additional ways that are not shown here.) Fields are based on how the National Library of Medicine (NLM) classifies the publication's journal and might not represent the specific topic of the publication. Translation tags are based on the publication type and the MeSH terms NLM assigns to the publication. Some publications (especially newer ones and publications not in PubMed) might not yet be assigned Field or Translation tags.) Click a Field or Translation tag to filter the publications.
    1. Huang M, Song A, Chen X, Ishtiaq S, Wang C, Hadsell DL, Wang QA, Zhu Y. Maternal Adipocyte Connexin43 Gap Junctions Affect Breastmilk Lactose Levels and Neonate Growth in Mice. Biology (Basel). 2022 Jul 07; 11(7). PMID: 36101404; PMCID: PMC9311998.
      Citations:    
    2. Huang J, Dai B, Qu H, Zhong Y, Ma Y, Luo J, Hadsell D, Shi H. Epidermal Growth Factor Stimulates Fatty Acid Synthesis Mainly via PLC-?1/Akt Signaling Pathway in Dairy Goat Mammary Epithelial Cells. Animals (Basel). 2020 May 28; 10(6). PMID: 32481546; PMCID: PMC7341511.
      Citations: 1     
    3. Hadsell DL, Hadsell LA, Rijnkels M, Carcamo-Bahena Y, Wei J, Williamson P, Grusak MA. In silico mapping of quantitative trait loci (QTL) regulating the milk ionome in mice identifies a milk iron locus on chromosome 1. Mamm Genome. 2018 10; 29(9-10):632-655. PMID: 30073618.
      Citations:    Fields:    Translation:AnimalsCells
    4. Jerry DJ, Shull JD, Hadsell DL, Rijnkels M, Dunphy KA, Schneider SS, Vandenberg LN, Majhi PD, Trentham-Dietz A, Byrne C. Genetic variation in sensitivity to estrogens and breast cancer risk. Mamm Genome. 2018 02; 29(1-2):24-37. PMID: 29487996; PMCID: PMC5936622.
      Citations: 10     Fields:    Translation:HumansAnimals
    5. Hadsell DL. Diet-Induced Inflammation and Mammary Ductal Development: Alternative Activation of Estrogen-Dependent Stromal-Epithelial Signaling. Endocrinology. 2017 10 01; 158(10):3088-3089. PMID: 28977613.
      Citations:    Fields:    Translation:HumansAnimalsCells
    6. Pham K, Dong J, Jiang X, Qu Y, Yu H, Yang Y, Olea W, Marini JC, Chan L, Wang J, Wehrens XH, Cui X, Li Y, Hadsell DL, Cheng N. Loss of glutaredoxin 3 impedes mammary lobuloalveolar development during pregnancy and lactation. Am J Physiol Endocrinol Metab. 2017 03 01; 312(3):E136-E149. PMID: 27894063; PMCID: PMC5374299.
      Citations: 4     Fields:    Translation:AnimalsCells
    7. Guthrie G, Kulkarni M, Vlaardingerbroek H, Stoll B, Ng K, Martin C, Belmont J, Hadsell D, Heird W, Newgard CB, Olutoye O, van Goudoever J, Lauridsen C, He X, Schuchman EH, Burrin D. Multi-omic profiles of hepatic metabolism in TPN-fed preterm pigs administered new generation lipid emulsions. J Lipid Res. 2016 09; 57(9):1696-711. PMID: 27474222; PMCID: PMC5003156.
      Citations: 8     Fields:    Translation:Animals
    8. Hadsell DL, Hadsell LA, Olea W, Rijnkels M, Creighton CJ, Smyth I, Short KM, Cox LL, Cox TC. In-silico QTL mapping of postpubertal mammary ductal development in the mouse uncovers potential human breast cancer risk loci. Mamm Genome. 2015 Feb; 26(1-2):57-79. PMID: 25552398; PMCID: PMC4548818.
      Citations: 6     Fields:    Translation:HumansAnimals
    9. Hadsell DL, Wei J, Olea W, Hadsell LA, Renwick A, Thomson PC, Shariflou M, Williamson P. In silico QTL mapping of maternal nurturing ability with the mouse diversity panel. Physiol Genomics. 2012 Aug 17; 44(16):787-98. PMID: 22759921; PMCID: PMC3774570.
      Citations: 4     Fields:    Translation:Animals
    10. Neville MC, Anderson SM, McManaman JL, Badger TM, Bunik M, Contractor N, Crume T, Dabelea D, Donovan SM, Forman N, Frank DN, Friedman JE, German JB, Goldman A, Hadsell D, Hambidge M, Hinde K, Horseman ND, Hovey RC, Janoff E, Krebs NF, Lebrilla CB, Lemay DG, MacLean PS, Meier P, Morrow AL, Neu J, Nommsen-Rivers LA, Raiten DJ, Rijnkels M, Seewaldt V, Shur BD, VanHouten J, Williamson P. Lactation and neonatal nutrition: defining and refining the critical questions. J Mammary Gland Biol Neoplasia. 2012 Jun; 17(2):167-88. PMID: 22752723; PMCID: PMC3428522.
      Citations: 42     Fields:    Translation:HumansAnimals
    11. Mohammad MA, Hadsell DL, Haymond MW. Gene regulation of UDP-galactose synthesis and transport: potential rate-limiting processes in initiation of milk production in humans. Am J Physiol Endocrinol Metab. 2012 Aug 01; 303(3):E365-76. PMID: 22649065; PMCID: PMC3423122.
      Citations: 22     Fields:    Translation:Humans
    12. Hadsell DL. Lactation Biology Symposium: circadian clocks and photoperiod in mammary gland development and lactation. J Anim Sci. 2012 Mar; 90(3):742-3. PMID: 22345105.
      Citations:    Fields:    Translation:Animals
    13. Maningat PD, Sen P, Rijnkels M, Hadsell DL, Bray MS, Haymond MW. Short-term administration of rhGH increases markers of cellular proliferation but not milk protein gene expression in normal lactating women. Physiol Genomics. 2011 Apr 27; 43(8):381-91. PMID: 21205870; PMCID: PMC3092339.
      Citations: 9     Fields:    Translation:HumansCells
    14. Hadsell DL, Olea W, Wei J, Fiorotto ML, Engler DA, Collier RJ, Matsunami RK. Developmental regulation of mitochondrial biogenesis and function in the mouse mammary gland during a prolonged lactation cycle. Physiol Genomics. 2011 Mar 29; 43(6):271-85. PMID: 21189371.
      Citations: 5     Fields:    Translation:AnimalsCells
    15. Stoll B, Horst DA, Cui L, Chang X, Ellis KJ, Hadsell DL, Suryawan A, Kurundkar A, Maheshwari A, Davis TA, Burrin DG. Chronic parenteral nutrition induces hepatic inflammation, steatosis, and insulin resistance in neonatal pigs. J Nutr. 2010 Dec; 140(12):2193-200. PMID: 20980637; PMCID: PMC2981005.
      Citations: 35     Fields:    Translation:Animals
    16. Maningat PD, Sen P, Rijnkels M, Sunehag AL, Hadsell DL, Bray M, Haymond MW. Gene expression in the human mammary epithelium during lactation: the milk fat globule transcriptome. Physiol Genomics. 2009 Mar 03; 37(1):12-22. PMID: 19018045; PMCID: PMC2661101.
      Citations: 56     Fields:    Translation:HumansAnimalsCells
    17. Hadsell DL, Parlow AF, Torres D, George J, Olea W. Enhancement of maternal lactation performance during prolonged lactation in the mouse by mouse GH and long-R3-IGF-I is linked to changes in mammary signaling and gene expression. J Endocrinol. 2008 Jul; 198(1):61-70. PMID: 18577570.
      Citations: 5     Fields:    Translation:AnimalsCells
    18. Maningat PD, Sen P, Sunehag AL, Hadsell DL, Haymond MW. Regulation of gene expression in human mammary epithelium: effect of breast pumping. J Endocrinol. 2007 Dec; 195(3):503-11. PMID: 18000312.
      Citations: 14     Fields:    Translation:HumansAnimalsCells
    19. Hadsell DL, Olea W, Lawrence N, George J, Torres D, Kadowaki T, Lee AV. Decreased lactation capacity and altered milk composition in insulin receptor substrate null mice is associated with decreased maternal body mass and reduced insulin-dependent phosphorylation of mammary Akt. J Endocrinol. 2007 Aug; 194(2):327-36. PMID: 17641282.
      Citations: 12     Fields:    Translation:AnimalsCells
    20. Heckman BM, Chakravarty G, Vargo-Gogola T, Gonzales-Rimbau M, Hadsell DL, Lee AV, Settleman J, Rosen JM. Crosstalk between the p190-B RhoGAP and IGF signaling pathways is required for embryonic mammary bud development. Dev Biol. 2007 Sep 01; 309(1):137-49. PMID: 17662267; PMCID: PMC4011021.
      Citations: 24     Fields:    Translation:AnimalsCells
    21. Dearth RK, Cui X, Kim HJ, Hadsell DL, Lee AV. Oncogenic transformation by the signaling adaptor proteins insulin receptor substrate (IRS)-1 and IRS-2. Cell Cycle. 2007 Mar 15; 6(6):705-13. PMID: 17374994.
      Citations: 86     Fields:    Translation:HumansAnimals
    22. Dearth RK, Cui X, Kim HJ, Kuiatse I, Lawrence NA, Zhang X, Divisova J, Britton OL, Mohsin S, Allred DC, Hadsell DL, Lee AV. Mammary tumorigenesis and metastasis caused by overexpression of insulin receptor substrate 1 (IRS-1) or IRS-2. Mol Cell Biol. 2006 Dec; 26(24):9302-14. PMID: 17030631; PMCID: PMC1698542.
      Citations: 76     Fields:    Translation:HumansAnimalsCells
    23. Divisova J, Kuiatse I, Lazard Z, Weiss H, Vreeland F, Hadsell DL, Schiff R, Osborne CK, Lee AV. The growth hormone receptor antagonist pegvisomant blocks both mammary gland development and MCF-7 breast cancer xenograft growth. Breast Cancer Res Treat. 2006 Aug; 98(3):315-27. PMID: 16541323.
      Citations: 39     Fields:    Translation:HumansAnimalsCells
    24. Hadsell DL, Torres D, George J, Capuco AV, Ellis SE, Fiorotto ML. Changes in secretory cell turnover, and mitochondrial oxidative damage in the mouse mammary gland during a single prolonged lactation cycle suggest the possibility of accelerated cellular aging. Exp Gerontol. 2006 Mar; 41(3):271-81. PMID: 16442254.
      Citations: 8     Fields:    Translation:AnimalsCells
    25. Keasler VV, Lerat H, Madden CR, Finegold MJ, McGarvey MJ, Mohammed EM, Forbes SJ, Lemon SM, Hadsell DL, Grona SJ, Hollinger FB, Slagle BL. Increased liver pathology in hepatitis C virus transgenic mice expressing the hepatitis B virus X protein. Virology. 2006 Apr 10; 347(2):466-75. PMID: 16427673.
      Citations: 17     Fields:    Translation:AnimalsCells
    26. Guan X, Karpen HE, Stephens J, Bukowski JT, Niu S, Zhang G, Stoll B, Finegold MJ, Holst JJ, Hadsell D, Hadsell DL, Nichols BL, Burrin DG. GLP-2 receptor localizes to enteric neurons and endocrine cells expressing vasoactive peptides and mediates increased blood flow. Gastroenterology. 2006 Jan; 130(1):150-64. PMID: 16401478.
      Citations: 80     Fields:    Translation:HumansAnimalsCells
    27. Hadsell DL, Torres DT, Lawrence NA, George J, Parlow AF, Lee AV, Fiorotto ML. Overexpression of des(1-3) insulin-like growth factor 1 in the mammary glands of transgenic mice delays the loss of milk production with prolonged lactation. Biol Reprod. 2005 Dec; 73(6):1116-25. PMID: 16079306.
      Citations: 11     Fields:    Translation:AnimalsCells
    28. Carboni JM, Lee AV, Hadsell DL, Rowley BR, Lee FY, Bol DK, Camuso AE, Gottardis M, Greer AF, Ho CP, Hurlburt W, Li A, Saulnier M, Velaparthi U, Wang C, Wen ML, Westhouse RA, Wittman M, Zimmermann K, Rupnow BA, Wong TW. Tumor development by transgenic expression of a constitutively active insulin-like growth factor I receptor. Cancer Res. 2005 May 01; 65(9):3781-7. PMID: 15867374.
      Citations: 77     Fields:    Translation:HumansAnimals
    29. Hadsell DL. Genetic manipulation of mammary gland development and lactation. Adv Exp Med Biol. 2004; 554:229-51. PMID: 15384580.
      Citations: 2     Fields:    Translation:HumansAnimalsCells
    30. Oesterreich S, Deng W, Jiang S, Cui X, Ivanova M, Schiff R, Kang K, Hadsell DL, Lee AV, Behrens J. Estrogen-mediated down-regulation of E-cadherin in breast cancer cells. Cancer Res. 2003 Sep 01; 63(17):5203-8. PMID: 14500345.
      Citations: 45     Fields:    Translation:HumansCells
    31. Hadsell DL, Bonnette S, George J, Torres D, Klimentidis Y, Klementidis Y, Gao S, Haney PM, Summy-Long J, Soloff MS, Parlow AF, Sirito M, Sawadogo M. Diminished milk synthesis in upstream stimulatory factor 2 null mice is associated with decreased circulating oxytocin and decreased mammary gland expression of eukaryotic initiation factors 4E and 4G. Mol Endocrinol. 2003 Nov; 17(11):2251-67. PMID: 12907752.
      Citations: 9     Fields:    Translation:Animals
    32. Hadsell DL. The insulin-like growth factor system in normal mammary gland function. Breast Dis. 2003; 17:3-14. PMID: 15687673.
      Citations: 6     Fields:    
    33. Lee AV, Schiff R, Cui X, Sachdev D, Yee D, Gilmore AP, Streuli CH, Oesterreich S, Hadsell DL. New mechanisms of signal transduction inhibitor action: receptor tyrosine kinase down-regulation and blockade of signal transactivation. Clin Cancer Res. 2003 Jan; 9(1 Pt 2):516S-23S. PMID: 12538509.
      Citations: 2     Fields:    Translation:HumansCells
    34. Hovey RC, Harris J, Hadsell DL, Lee AV, Ormandy CJ, Vonderhaar BK. Local insulin-like growth factor-II mediates prolactin-induced mammary gland development. Mol Endocrinol. 2003 Mar; 17(3):460-71. PMID: 12554791.
      Citations: 29     Fields:    Translation:Animals
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