HAROLDSHINEHAROLD SHINE29.70508570000000-95.401808700000003216SHINE, HAROLDProfessor Emeritusprns:coAuthorOfcoauthor ofprns:endDateend dateFaculty Rankprns:fullNamefull nameprns:grantAwardedBygrant awarded byprns:hasAuthorListauthor listprns:hasFacultyRankhas faculty rankprns:hasNetworkhas networkprns:hasPublicationVenuepublished inprns:informationResourceReferenceinformation resource referenceprns:isPrimaryPositionis primary positionprns:latitudelatitudeprns:longitudelongitudeprns:mainImagephotoprns:maxWeightmaximum weightprns:medlineTAjournal title abbreviationprns:meshDescriptorUIMeSH DescriptorUIprns:meshSemanticGroupNameMeSH semantic group nameprns:minWeightminimum weightprns:numberOfAuthorsnumber of authorsprns:numberOfConnectionsnumber of connectionsprns:numberOfPublicationsnumber of publicationsprns:personIdPerson IDprns:personInPrimaryPositionperson in primary positionprns:physicalNeighborOfphysical neighborprns:positionInDepartmentposition in departmentprns:positionInDivisionposition in divisionprns:predicateNodepredicate nodeprns:principalInvestigatorNameprincipal investigator nameprns:publicationDatepublication dateprns:similarTosimilar toprns:sortOrdersort orderprns:startDatestart dateprns:uniquenessWeightuniqueness weightprns:yearyearAcademic ArticleArticleDocumentbibo:pmidPubMed IdentifierAddressvivo:address1address line 1vivo:addressCitycityvivo:addressPostalCodepostal codevivo:addressStatestate or provinceAgreementvivo:authorInAuthorshipselected publicationsvivo:authorRankauthor rank in publicationAuthorshipDepartmentDivisionGrantvivo:hasResearchArearesearch areasvivo:hasResearcherRoleresearch activitiesvivo:hrJobTitleHR job titleInformation Resourcevivo:linkedAuthorlinked authorvivo:linkedInformationResourcelinked information resourcevivo:mailingAddressmailing addressvivo:personInPositionpositionsPositionvivo:positionInOrganizationposition in organizationvivo:preferredTitlepreferred titleResearcher Rolevivo:researcherRoleOfresearcher role ofRolevivo:roleContributesTocontributes tovivo:sponsorAwardIdsponsor award idrdf:predicatepredicaterdf:typetyperdfs:labellabelConceptAgentfoaf:firstNamefirst namefoaf:lastNamelast nameOrganizationPerson25549050Kathe C, Hutson TH, Chen Q, Shine HD, McMahon SB, Moon LDJournal of visualized experiments : JoVEUnilateral pyramidotomy of the corticospinal tract in rats for assessment of neuroplasticity-inducing therapies. J Vis Exp. 2014 Dec 15; (94).J Vis Exp2014-12-15T00:00:002014Unilateral pyramidotomy of the corticospinal tract in rats for assessment of neuroplasticity-inducing therapies.Authorship 1074802Authorship 1201535Authorship 17742Authorship 247149Authorship 281841Anesthesiology & PeriOperative MedicineMD AndersonHUI-LINPANHUI-LIN PAN9317PAN, HUI-LINProfessorAuthorship 629631Authorship 744584Authorship 773693Center for Cell & Gene TherapyDepartment of Physical Medicine & R8159705Chen SH, Shine HD, Goodman JC, Grossman RG, Woo SLProceedings of the National Academy of Sciences of the United States of AmericaGene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo. Proc Natl Acad Sci U S A. 1994 Apr 12; 91(8):3054-7.Proc Natl Acad Sci U S A1994-04-12T00:00:001994Gene therapy for brain tumors: regression of experimental gliomas by adenovirus-mediated gene transfer in vivo.9254662Baumgartner BJ, Shine HDThe Journal of neuroscience : the official journal of the Society for NeuroscienceTargeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population. J Neurosci. 1997 Sep 01; 17(17):6504-11.J Neurosci1997-09-01T00:00:001997Targeted transduction of CNS neurons with adenoviral vectors carrying neurotrophic factor genes confers neuroprotection that exceeds the transduced population.1319503Rabinovsky ED, Smith GM, Browder DP, Shine HD, McManaman JLJournal of neuroscience researchPeripheral nerve injury down-regulates CNTF expression in adult rat sciatic nerves. J Neurosci Res. 1992 Jan; 31(1):188-92.J Neurosci Res1992-01-01T00:00:001992Peripheral nerve injury down-regulates CNTF expression in adult rat sciatic nerves.8339774Smith GM, Rabinovsky ED, McManaman JL, Shine HDExperimental neurologyTemporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury. Exp Neurol. 1993 Jun; 121(2):239-47.Exp Neurol1993-06-01T00:00:001993Temporal and spatial expression of ciliary neurotrophic factor after peripheral nerve injury.Authorship 30151971370079Shine HD, Readhead C, Popko B, Hood L, Sidman RLJournal of neurochemistryMorphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis. J Neurochem. 1992 Jan; 58(1):342-9.J Neurochem1992-01-01T00:00:001992Morphometric analysis of normal, mutant, and transgenic CNS: correlation of myelin basic protein expression to myelinogenesis.26614754Duricki DA, Hutson TH, Kathe C, Soleman S, Gonzalez-Carter D, Petruska JC, Shine HD, Chen Q, Wood TC, Bernanos M, Cash D, Williams SC, Gage FH, Moon LDBrain : a journal of neurologyDelayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke. Brain. 2016 Jan; 139(Pt 1):259-75.Brain2015-11-27T00:00:002015Delayed intramuscular human neurotrophin-3 improves recovery in adult and elderly rats after stroke.1492590Smith GM, Shine HDInternational journal of developmental neuroscience : the official journal of the International Society for Developmental NeuroscienceImmunofluorescent labeling of tight junctions in the rat brain and spinal cord. Int J Dev Neurosci. 1992 Oct; 10(5):387-92.Int J Dev Neurosci1992-10-01T00:00:001992Immunofluorescent labeling of tight junctions in the rat brain and spinal cord.8793548Goodman JC, Trask TW, Chen SH, Woo SL, Grossman RG, Carey KD, Hubbard GB, Carrier DA, Rajagopalan S, Aguilar-Cordova E, Shine HDHuman gene therapyAdenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies. Hum Gene Ther. 1996 Jun 20; 7(10):1241-50.Hum Gene Ther1996-06-20T00:00:001996Adenoviral-mediated thymidine kinase gene transfer into the primate brain followed by systemic ganciclovir: pathologic, radiologic, and molecular studies.12083633Sivaraman L, Gay J, Hilsenbeck SG, Shine HD, Conneely OM, Medina D, O'Malley BWBreast cancer research and treatmentEffect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis. Breast Cancer Res Treat. 2002 May; 73(1):75-83.Breast Cancer Res Treat2002-05-01T00:00:002002Effect of selective ablation of proliferating mammary epithelial cells on MNU induced rat mammary tumorigenesis.9176511Shine HD, Wyde PR, Aguilar-Cordova E, Chen SH, Woo SL, Grossman RG, Goodman JCGene therapyNeurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat). Gene Ther. 1997 Apr; 4(4):275-9.Gene Ther1997-04-01T00:00:001997Neurotoxicity of intracerebral injection of a replication-defective adenoviral vector in a semipermissive species (cotton rat).12542848Zou L, Yuan X, Long Y, Shine HD, Yang KHuman gene therapyImprovement of spatial learning and memory after adenovirus-mediated transfer of the nerve growth factor gene to aged rat brain. Hum Gene Ther. 2002 Dec 10; 13(18):2173-84.Hum Gene Ther2002-12-10T00:00:002002Improvement of spatial learning and memory after adenovirus-mediated transfer of the nerve growth factor gene to aged rat brain.12598631Zhou L, Baumgartner BJ, Hill-Felberg SJ, McGowen LR, Shine HDThe Journal of neuroscience : the official journal of the Society for NeuroscienceNeurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord. J Neurosci. 2003 Feb 15; 23(4):1424-31.J Neurosci2003-02-15T00:00:002003Neurotrophin-3 expressed in situ induces axonal plasticity in the adult injured spinal cord.9856860Baumgartner BJ, Shine HDJournal of neuroscience researchPermanent rescue of lesioned neonatal motoneurons and enhanced axonal regeneration by adenovirus-mediated expression of glial cell-line-derived neurotrophic factor. J Neurosci Res. 1998 Dec 15; 54(6):766-77.J Neurosci Res1998-12-15T00:00:001998Permanent rescue of lesioned neonatal motoneurons and enhanced axonal regeneration by adenovirus-mediated expression of glial cell-line-derived neurotrophic factor.One Baylor PlazaHouston, 77030TX74Professor10Assistant Professor14Associate Professor3Adjunct Associate Professor78Professor Emeritus6Adjunct Professor47Distinguished Service Professor16928183Chen Q, Zhou L, Shine HDJournal of neurotraumaExpression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cord. J Neurotrauma. 2006 Aug; 23(8):1254-60.J Neurotrauma2006-08-01T00:00:002006Expression of neurotrophin-3 promotes axonal plasticity in the acute but not chronic injured spinal cord.17982417Qi H, Chuang EY, Yoon KC, de Paiva CS, Shine HD, Jones DB, Pflugfelder SC, Li DQMolecular visionPatterned expression of neurotrophic factors and receptors in human limbal and corneal regions. Mol Vis. 2007 Oct 16; 13:1934-41.Mol Vis2007-10-16T00:00:002007Patterned expression of neurotrophic factors and receptors in human limbal and corneal regions.14515351Zhou L, Shine HDJournal of neuroscience researchNeurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury. J Neurosci Res. 2003 Oct 15; 74(2):221-6.J Neurosci Res2003-10-15T00:00:002003Neurotrophic factors expressed in both cortex and spinal cord induce axonal plasticity after spinal cord injury.14673088Olmsted-Davis EA, Gugala Z, Camargo F, Gannon FH, Jackson K, Kienstra KA, Shine HD, Lindsey RW, Hirschi KK, Goodell MA, Brenner MK, Davis ARProceedings of the National Academy of Sciences of the United States of AmericaPrimitive adult hematopoietic stem cells can function as osteoblast precursors. Proc Natl Acad Sci U S A. 2003 Dec 23; 100(26):15877-82.Proc Natl Acad Sci U S A2003-12-12T00:00:002003Primitive adult hematopoietic stem cells can function as osteoblast precursors.19530170Grider MH, Park D, Spencer DM, Shine HDJournal of neuroscience researchLipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively. J Neurosci Res. 2009 Nov 01; 87(14):3033-42.J Neurosci Res2009-11-01T00:00:002009Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively.16206279Grider MH, Mamounas LA, Le W, Shine HDJournal of neuroscience researchIn situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion. J Neurosci Res. 2005 Nov 01; 82(3):404-12.J Neurosci Res2005-11-01T00:00:002005In situ expression of brain-derived neurotrophic factor or neurotrophin-3 promotes sprouting of cortical serotonergic axons following a neurotoxic lesion.17980361Qi H, Li DQ, Shine HD, Chen Z, Yoon KC, Jones DB, Pflugfelder SCExperimental eye researchNerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells. Exp Eye Res. 2008 Jan; 86(1):34-40.Exp Eye Res2007-09-15T00:00:002007Nerve growth factor and its receptor TrkA serve as potential markers for human corneal epithelial progenitor cells.18191837Chen Q, Smith GM, Shine HDExperimental neurologyImmune activation is required for NT-3-induced axonal plasticity in chronic spinal cord injury. Exp Neurol. 2008 Feb; 209(2):497-509.Exp Neurol2007-12-07T00:00:002007Immune activation is required for NT-3-induced axonal plasticity in chronic spinal cord injury.17575166Ahmed N, Ratnayake M, Savoldo B, Perlaky L, Dotti G, Wels WS, Bhattacharjee MB, Gilbertson RJ, Shine HD, Weiss HL, Rooney CM, Heslop HE, Gottschalk SCancer researchRegression of experimental medulloblastoma following transfer of HER2-specific T cells. Cancer Res. 2007 Jun 15; 67(12):5957-64.Cancer Res2007-06-15T00:00:002007Regression of experimental medulloblastoma following transfer of HER2-specific T cells.18938159Qi H, Shine HD, Li DQ, de Paiva CS, Farley WJ, Jones DB, Pflugfelder SCExperimental eye researchGlial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs. Exp Eye Res. 2008 Dec; 87(6):580-6.Exp Eye Res2008-10-07T00:00:002008Glial cell-derived neurotrophic factor gene delivery enhances survival of human corneal epithelium in culture and the overexpression of GDNF in bioengineered constructs.7884826Perez-Cruet MJ, Trask TW, Chen SH, Goodman JC, Woo SL, Grossman RG, Shine HDJournal of neuroscience researchAdenovirus-mediated gene therapy of experimental gliomas. J Neurosci Res. 1994 Nov 01; 39(4):506-11.J Neurosci Res1994-11-01T00:00:001994Adenovirus-mediated gene therapy of experimental gliomas.8590067Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HDBrain researchAdenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome. Brain Res. 1995 Sep 11; 691(1-2):76-82.Brain Res1995-09-11T00:00:001995Adenovirus-mediated gene therapy for experimental spinal cord tumors: tumoricidal efficacy and functional outcome.8590736Colak A, Goodman JC, Chen SH, Woo SL, Grossman RG, Shine HDHuman gene therapyAdenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain. Hum Gene Ther. 1995 Oct; 6(10):1317-22.Hum Gene Ther1995-10-01T00:00:001995Adenovirus-mediated gene therapy in an experimental model of breast cancer metastatic to the brain.9743571Baumgartner BJ, Shine HDExperimental neurologyNeuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor. Exp Neurol. 1998 Sep; 153(1):102-12.Exp Neurol1998-09-01T00:00:001998Neuroprotection of spinal motoneurons following targeted transduction with an adenoviral vector carrying the gene for glial cell line-derived neurotrophic factor.10933931Trask TW, Trask RP, Aguilar-Cordova E, Shine HD, Wyde PR, Goodman JC, Hamilton WJ, Rojas-Martinez A, Chen SH, Woo SL, Grossman RGMolecular therapy : the journal of the American Society of Gene TherapyPhase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors. Mol Ther. 2000 Feb; 1(2):195-203.Mol Ther2000-02-01T00:00:002000Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors.11746267Ayala GE, Wheeler TM, Shine HD, Schmelz M, Frolov A, Chakraborty S, Rowley DThe ProstateIn vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer. Prostate. 2001 Nov 01; 49(3):213-23.Prostate2001-11-01T00:00:002001In vitro dorsal root ganglia and human prostate cell line interaction: redefining perineural invasion in prostate cancer.1691511Shine HD, Readhead C, Popko B, Hood L, Sidman RLProgress in clinical and biological researchMyelin basic protein and myelinogenesis: morphometric analysis of normal, mutant and transgenic central nervous system. Prog Clin Biol Res. 1990; 336:81-92.Prog Clin Biol Res1990-01-01T00:00:001990Myelin basic protein and myelinogenesis: morphometric analysis of normal, mutant and transgenic central nervous system.16469388Grider MH, Chen Q, Shine HDJournal of neuroscience methodsSemi-automated quantification of axonal densities in labeled CNS tissue. J Neurosci Methods. 2006 Sep 15; 155(2):172-9.J Neurosci Methods2006-02-08T00:00:002006Semi-automated quantification of axonal densities in labeled CNS tissue.true1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1Associate ProfessorAssociate Professortrue1Distinguished Service ProfessorDistinguished Service ProfessorD001369Anatomy1664030.777594AxonsD013119Disorders1233750.758936Spinal Cord InjuriesD009416Physiology621060.926913Nerve RegenerationD020933Chemicals & Drugs7150.988228Neurotrophin 3Authorship 932324730525223Duricki DA, Drndarski S, Bernanos M, Wood T, Bosch K, Chen Q, Shine HD, Simmons C, Williams SCR, McMahon SB, Begley DJ, Cash D, Moon LDFAnnals of neurologyStroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion. Ann Neurol. 2019 01; 85(1):32-46.Ann Neurol2018-12-28T00:00:002018Stroke Recovery in Rats after 24-Hour-Delayed Intramuscular Neurotrophin-3 Infusion.D009473Physiology1373050.811733Neuronal Plasticity2013-06-30NIHSHINE, HAROLD DAVID2010-07-01Neuroimmune Processes and Neuroplasticity in Chronic Spinal Cord InjuryI01RX0002412001-06-30NIHSHINE, HAROLD DAVID1997-07-15MECHANISMS OF BRAIN TUMOR CELL DEATH AFTER GENE TRANSFERR01NS0352801988-03-31NIHSHINE, HAROLD DAVID1985-04-01IMPLANTS CONTAINING CELLS SUPPORT PNS AXON REGENERATIONR23NS0222232006-05-31NIHSHINE, HAROLD DAVID1999-09-15GENE DELIVERY FOR SPIRAL CORD INJURY REPAIRR01NS0391982020-06-30NIHSHINE, HAROLD DAVID2015-07-01Neuroimmune Processes and Neuroplasticity in Chronic Spinal Cord InjuryR01NS084919Principal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorPrincipal InvestigatorCenter for Cell & Gene TherapyDepartment of AnesthesiologyDepartment of MedicineDepartment of NeuroscienceDepartment of OphthalmologyDepartment of Orthopedic SurgeryDepartment of PediatricsDepartment of Molecular & Cellular BiologyDepartment of Physical Medicine & RehabilitationAnesthesiologyMedicine-General Med/Ben TaubMolecular & Cellular BiologyNeuroscienceOphthalmologyOrthopedic SurgeryPediatrics-Hem/Onc Cell & Gene ThePediatrics-NeurologyPediatrics-NutritionBaylor College of MedicineKIMBERLEYTOLIASKIMBERLEY TOLIAS0.000000000000000.000000000000001061TOLIAS, KIMBERLEYProfessorMATTHEWRASBANDMATTHEW RASBAND0.000000000000000.000000000000001237RASBAND, MATTHEWProfessorLEECHANGLEE CHANG29.70508570000000-95.401808700000001262CHANG, LEEAssociate ProfessorSTEPHENPFLUGFELDERSTEPHEN PFLUGFELDER29.70508570000000-95.40180870000000167PFLUGFELDER, STEPHENProfessor2.02710.00439494251research areas0.1850040.013226918coauthor of22.78143.5423960similar to1135selected publicationsWAYNESHANDERAWAYNE SHANDERA29.70508570000000-95.401808700000003239SHANDERA, WAYNEAssociate ProfessorOPALWILLMONOPAL WILLMON29.70508570000000-95.401808700000004279WILLMON, OPALInstructorMILANDIMITRIJEVICMILAN DIMITRIJEVIC0.000000000000000.000000000000002306DIMITRIJEVIC, MILANProfessor EmeritusDE-QUANLIDE-QUAN LI29.70508570000000-95.40180870000000283LI, DE-QUANAssociate ProfessorHUDAZOGHBIHUDA ZOGHBI29.71010310000000-95.397396100000002830ZOGHBI, HUDADistinguished Service ProfessorAuthorship 1058003NABILAHMEDNABIL AHMED0.000000000000000.00000000000000613AHMED, NABILProfessorMAKOTOFUKUDAMAKOTO FUKUDA29.70508570000000-95.401808700000004313FUKUDA, MAKOTOAssociate ProfessorCALEBKEMERECALEB KEMERE29.70508570000000-95.401808700000004546KEMERE, CALEBAdjunct Associate ProfessorSTEPHENGOTTSCHALKSTEPHEN GOTTSCHALK0.000000000000000.0000000000000053GOTTSCHALK, STEPHENAdjunct ProfessorAuthorship 1267996Authorship 126913223825607Mulherkar S, Liu F, Chen Q, Narayanan A, Couvillon AD, Shine HD, Tolias KFPloS oneThe small GTPase RhoA is required for proper locomotor circuit assembly. PLoS One. 2013; 8(6):e67015.PLoS One2013-06-25T00:00:002013The small GTPase RhoA is required for proper locomotor circuit assembly.23907999Chen Q, Shine HDJournal of neuroscience researchNeuroimmune processes associated with Wallerian degeneration support neurotrophin-3-induced axonal sprouting in the injured spinal cord. J Neurosci Res. 2013 Oct; 91(10):1280-91.J Neurosci Res2013-08-01T00:00:002013Neuroimmune processes associated with Wallerian degeneration support neurotrophin-3-induced axonal sprouting in the injured spinal cord.Authorship 1080236true1Associate ProfessorAssociate Professortrue1ProfessorProfessortrue1InstructorInstructortrue1Professor EmeritusProfessor Emeritus2Professor EmeritusProfessor Emeritus3Professor EmeritusProfessor EmeritusAuthorship 11217311true1Adjunct Associate ProfessorAdjunct Associate ProfessorAuthorship 1170184Authorship 124254true1ProfessorProfessortrue1Associate ProfessorAssociate ProfessorAuthorship 1195803Authorship 1191772true1Associate ProfessorAssociate Professortrue1Adjunct ProfessorAdjunct Professortrue1ProfessorProfessortrue1Professor EmeritusProfessor Emeritustrue1ProfessorProfessorAuthorship 286203FELICIASKELTONFELICIA SKELTON7175SKELTON, FELICIAAssociate ProfessorAuthorship 281497Authorship 311092Authorship 339152Authorship 425923Authorship 432202Authorship 460014Authorship 507814Authorship 54235Authorship 591707Authorship 86104Authorship 996206Authorship 717922Authorship 752314Authorship 79691Authorship 1555644